Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
Oleg Butovsky, … , Merit E. Cudkowicz, Howard L. Weiner
Oleg Butovsky, … , Merit E. Cudkowicz, Howard L. Weiner
Published August 6, 2012
Citation Information: J Clin Invest. 2012;122(9):3063-3087. https://doi.org/10.1172/JCI62636.
View: Text | PDF
Research Article Neuroscience Article has an altmetric score of 29

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

  • Text
  • PDF
Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell death that is thought to involve aberrant immune responses. Here we investigated the role of innate immunity in a mouse model of ALS. We found that inflammatory monocytes were activated and that their progressive recruitment to the spinal cord, but not brain, correlated with neuronal loss. We also found a decrease in resident microglia in the spinal cord with disease progression. Prior to disease onset, splenic Ly6Chi monocytes expressed a polarized macrophage phenotype (M1 signature), which included increased levels of chemokine receptor CCR2. As disease onset neared, microglia expressed increased CCL2 and other chemotaxis-associated molecules, which led to the recruitment of monocytes to the CNS by spinal cord–derived microglia. Treatment with anti-Ly6C mAb modulated the Ly6Chi monocyte cytokine profile, reduced monocyte recruitment to the spinal cord, diminished neuronal loss, and extended survival. In humans with ALS, the analogous monocytes (CD14+CD16–) exhibited an ALS-specific microRNA inflammatory signature similar to that observed in the ALS mouse model, linking the animal model and the human disease. Thus, the profile of monocytes in ALS patients may serve as a biomarker for disease stage or progression. Our results suggest that recruitment of inflammatory monocytes plays an important role in disease progression and that modulation of these cells is a potential therapeutic approach.

Authors

Oleg Butovsky, Shafiuddin Siddiqui, Galina Gabriely, Amanda J. Lanser, Ben Dake, Gopal Murugaiyan, Camille E. Doykan, Pauline M. Wu, Reddy R. Gali, Lakshmanan K. Iyer, Robert Lawson, James Berry, Anna M. Krichevsky, Merit E. Cudkowicz, Howard L. Weiner

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2009 Total
Citations: 4 21 19 27 22 27 15 26 35 29 25 21 21 3 1 296
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (296)

Title and authors Publication Year
Immune conversations at the border: meningeal immunity in health and disease
Patel PU, Regmi A, Dass AI, Rojas OL
Frontiers in Immunology 2025
Cerebrospinal fluid and serum cytokine profiles in severe viral encephalitis with implications for refractory status epilepticus: a retrospective observational study
Huang P, Yang F, Dong R, Wen L, Zang Q, Song D, Guo J, Wang Y, Zhang R, Ren Z, Qin J, Teng J, Miao W
Frontiers in Immunology 2025
Causal associations between immune cells and psychiatric disorders: a bidirectional mendelian randomization analysis.
Li Y, Sun G, Cui Y, Ji S, Kan T
Naunyn-Schmiedeberg's archives of pharmacology 2025
An Expanded Access Protocol of RNS60 in Amyotrophic Lateral Sclerosis
Addy G, Scirocco E, Gelevski D, Rohrer M, Roderick A, McCormack M, Weiss Sadan A, Scalia J, Parikh N, Giacomelli E, Locatelli M, Neel DV, D'Agostino D, Leite A, Yu H, Sherman AV, Mock J, Kalmes A, Luppino S, Babu S, Berry J, Cudkowicz M, Paganoni S
Muscle & Nerve 2025
The roles of tissue resident macrophages in health and cancer
Cao M, Wang Z, Lan W, Xiang B, Liao W, Zhou J, Liu X, Wang Y, Zhang S, Lu S, Lang J, Zhao Y
Experimental Hematology and Oncology 2024
The Inflammatory Puzzle: Piecing together the Links between Neuroinflammation and Amyotrophic Lateral Sclerosis.
He D, Xu Y, Liu M, Cui L
Aging and disease 2024
Non-coding RNAs and neuroinflammation: implications for neurological disorders
Chen Y, Mateski J, Gerace L, Wheeler J, Burl J, Prakash B, Svedin C, Amrick R, Adams BD
Experimental Biology and Medicine 2024
Human pluripotent stem cell (hPSC)-derived microglia for the study of brain disorders. A comprehensive review of existing protocols
Teo F, Kok CY, Tan MJ, Je HS
2024
Discrepant Phenotyping of Monocytes Based on CX3CR1 and CCR2 Using Fluorescent Reporters and Antibodies
Sommer K, Garibagaoglu H, Paap EM, Wiendl M, Müller TM, Atreya I, Krönke G, Neurath MF, Zundler S
Cells 2024
Establishment of a high-content compatible platform to assess effects of monocyte-derived factors on neural stem cell proliferation and differentiation
Campo Garcia J, Bueno RJ, Salla M, Martorell-Serra I, Seeger B, Akbari N, Sperber P, Stachelscheid H, Infante-Duarte C, Paul F, Starossom SC
Scientific Reports 2024
An ALS-associated mutation dysregulates microglia-derived extracellular microRNAs in a sex-specific manner
Christoforidou E, Moody L, Joilin G, Simoes FA, Gordon D, Talbot K, Hafezparast M
Disease models & mechanisms 2024
MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review
Azam HM, Rößling RI, Geithe C, Khan MM, Dinter F, Hanack K, Prüß H, Husse B, Roggenbuck D, Schierack P, Rödiger S
Frontiers in molecular neuroscience 2024
Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS
Cihankaya H, Bader V, Winklhofer KF, Vorgerd M, Matschke J, Stahlke S, Theiss C, Matschke V
Cells 2024
Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping
Zhang D, Rubio Rodríguez-Kirby LA, Lin Y, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Wang S, Chen XL, Gao F, Wang D, Xu H, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R
2024
Inhibition of glycolytic reprogramming suppresses innate immune-mediated inflammation in experimental amyotrophic lateral sclerosis.
Yu L, Wu N, Choi O, Nguyen KD
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024
Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology
Pramotton FM, Spitz S, Kamm RD
Advanced Science 2024
Unveiling the hidden connection: the blood-brain barrier’s role in epilepsy
Han J, Wang Y, Wei P, Lu D, Shan Y
Frontiers in Neurology 2024
Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping
Zhang D, Rodríguez-Kirby LA, Lin Y, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Wang S, Chen XL, Gao F, Wang D, Xu H, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R
Research Square 2024
A microRNA diagnostic biomarker for amyotrophic lateral sclerosis
Banack SA, Dunlop RA, Mehta P, Mitsumoto H, Wood SP, Han M, Cox PA
Brain Communications 2024
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling
Kigar SL, Lynall ME, DePuyt AE, Atkinson R, Sun VH, Samuels JD, Eassa NE, Poffenberger CN, Lehmann ML, Listwak SJ, Livak F, Elkahloun AG, Clatworthy MR, Bullmore ET, Herkenham M
bioRxiv 2024
A Review of Biomarkers of Amyotrophic Lateral Sclerosis: A Pathophysiologic Approach.
Alshehri RS, Abuzinadah AR, Alrawaili MS, Alotaibi MK, Alsufyani HA, Alshanketi RM, AlShareef AA
International journal of molecular sciences 2024
Exploring dysregulated miRNAs in ALS: implications for disease pathogenesis and early diagnosis.
Maity D, Kaundal RK
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2024
The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets
Ekwudo MN, Gubert C, Hannan AJ
The Febs Journal 2024
Immune mechanisms and shared immune targets in neurodegenerative diseases.
Weiner HL
Nature reviews. Neurology 2024
The Current Potential Pathogenesis of Amyotrophic Lateral Sclerosis.
Jiang S, Xu R
Molecular neurobiology 2024
The Need for Biomarkers in the ALS–FTD Spectrum: A Clinical Point of View on the Role of Proteomics
Vignaroli F, Mele A, Tondo G, De Giorgis V, Manfredi M, Comi C, Mazzini L, De Marchi F
Proteomes 2023
Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell
Dermitzakis I, Manthou ME, Meditskou S, Tremblay MÈ, Petratos S, Zoupi L, Boziki M, Kesidou E, Simeonidou C, Theotokis P
Current issues in molecular biology 2023
Telomerase reverse transcriptase and neurodegenerative diseases
Yu X, Liu MM, Zheng CY, Liu YT, Wang Z, Wang ZY
Frontiers in immunology 2023
Cortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology.
Filipi T, Matusova Z, Abaffy P, Vanatko O, Tureckova J, Benesova S, Kubiskova M, Kirdajova D, Zahumensky J, Valihrach L, Anderova M
Scientific Reports 2023
Role of NCKAP1 in the Defective Phagocytic Function of Microglia-Like Cells Derived from Rapidly Progressing Sporadic ALS.
Noh MY, Kwon MS, Oh KW, Nahm M, Park J, Kim YE, Ki CS, Jin HK, Bae JS, Kim SH
Molecular Neurobiology 2023
The contribution of the peripheral immune system to neurodegeneration.
Berriat F, Lobsiger CS, Boillée S
Nature Neuroscience 2023
Peripheral immune system modulates Purkinje cell degeneration in Niemann–Pick disease type C1
Yasuda T, Uchiyama T, Watanabe N, Ito N, Nakabayashi K, Mochizuki H, Onodera M
Life science alliance 2023
The triggering receptor expressed on myeloid cells 2–apolipoprotein E signaling pathway in diseases
Lyu S, Lan Z, Li C
Chinese Medical Journal 2023
Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males.
Abou-El-Hassan H, Rezende RM, Izzy S, Gabriely G, Yahya T, Tatematsu BK, Habashy KJ, Lopes JR, de Oliveira GLV, Maghzi AH, Yin Z, Cox LM, Krishnan R, Butovsky O, Weiner HL
Nature Communications 2023
Looking to the Future of the Role of Macrophages and Extracellular Vesicles in Neuroinflammation in ALS.
Carata E, Muci M, Di Giulio S, Mariano S, Panzarini E
International journal of molecular sciences 2023
Microglial crosstalk with astrocytes and immune cells in amyotrophic lateral sclerosis.
Calafatti M, Cocozza G, Limatola C, Garofalo S
Frontiers in immunology 2023
SOD1G93A Astrocyte-Derived Extracellular Vesicles Induce Motor Neuron Death by a miRNA-155-5p-Mediated Mechanism
Marton S, Miquel E, Acosta-Rodríguez J, Fontenla S, Libisch G, Cassina P
ASN NEURO 2023
The role of peripheral immunity in ALS: a population-based study.
Grassano M, Manera U, De Marchi F, Cugnasco P, Matteoni E, Daviddi M, Solero L, Bombaci A, Palumbo F, Vasta R, Canosa A, Salamone P, Fuda G, Casale F, Mazzini L, Calvo A, Moglia C, Chiò A
Annals of Clinical and Translational Neurology 2023
Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease.
Lopes JR, Zhang X, Mayrink J, Tatematsu BK, Guo L, LeServe DS, Abou-El-Hassan H, Rong F, Dalton MJ, Oliveira MG, Lanser TB, Liu L, Butovsky O, Rezende RM, Weiner HL
Proceedings of the National Academy of Sciences 2023
From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology
Toader C, Dobrin N, Brehar FM, Popa C, Covache-Busuioc RA, Glavan LA, Costin HP, Bratu BG, Corlatescu AD, Popa AA, Ciurea AV
International journal of molecular sciences 2023
Immunology of amyotrophic lateral sclerosis – role of the innate and adaptive immunity
Mimic S, Aru B, Pehlivanoğlu C, Sleiman H, Andjus PR, Yanıkkaya Demirel G
Frontiers in neuroscience 2023
Depletion of perivascular macrophages delays ALS disease progression by ameliorating blood-spinal cord barrier impairment in SOD1G93A mice
Adachi K, Miyata K, Chida Y, Hirose M, Morisaki Y, Yamanaka K, Misawa H
Frontiers in cellular neuroscience 2023
Elucidating the neuroimmunology of traumatic brain injury: methodological approaches to unravel intercellular communication and function
Abou-El-Hassan H, Bernstock JD, Chalif JI, Yahya T, Rezende RM, Weiner HL, Izzy S
Frontiers in cellular neuroscience 2023
Eosinophils at diagnosis are elevated in amyotrophic lateral sclerosis.
Yang J, Liu T, Zhang L, Li X, Du FP, Liu Q, Dong H, Liu Y
Frontiers in neurology 2023
Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice
Eleonore Bertin, Audrey Martinez, Anne Fayoux, Kevin Carvalho, Sara Carracedo, Pierre-Olivier Fernagut, Friedrich Nolte, David Blum, Sandrine S Bertrand, Eric Boue-Grabot
2022
ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression
H Quek, C Cuní-López, R Stewart, T Colletti, A Notaro, T Nguyen, Y Sun, C Guo, M Lupton, T Roberts, Y Lim, L Oikari, V Bella, A White
Journal of Neuroinflammation 2022
Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis
C Cui, C Ingre, L Yin, X Li, J Andersson, C Seitz, N Ruffin, Y Pawitan, F Piehl, F Fang
eLife 2022
MicroRNA expression in animal models of amyotrophic lateral sclerosis and potential therapeutic approaches
B Martinez, PV Peplow
NEURAL REGEN RES 2022
The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis
L Cox, N Calcagno, C Gauthier, C Madore, O Butovsky, H Weiner
Microbiome 2022
The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
P West, A McCorkindale, B Guennewig, T Ashhurst, B Viengkhou, E Hayashida, S Jung, O Butovsky, I Campbell, M Hofer
Journal of Neuroinflammation 2022
The Expression of Active CD11b Monocytes in Blood and Disease Progression in Amyotrophic Lateral Sclerosis
O Yildiz, J Schroth, V Lombardi, V Pucino, Y Bobeva, P Yip, K Schmierer, C Mauro, T Tree, S Henson, A Malaspina
International journal of molecular sciences 2022
Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS
C Eitan, A Siany, E Barkan, T Olender, K van Eijk, M Moisse, S Farhan, Y Danino, E Yanowski, H Marmor-Kollet, N Rivkin, N Yacovzada, S Hung, J Cooper-Knock, C Yu, C Louis, S Masters, K Kenna, R van der Spek, W Sproviero, A Khleifat, A Iacoangeli, A Shatunov, A Jones, Y Elbaz-Alon, Y Cohen, E Chapnik, D Rothschild, O Weissbrod, G Beck, E Ainbinder, S Ben-Dor, S Werneburg, D Schafer, R Brown, P Shaw, P Damme, L van den Berg, H Phatnani, E Segal, J Ichida, A Al-Chalabi, J Veldink, J Cooper-Knock, K Kenna, P Damme, L van den Berg, E Hornstein, E Hornstein
Nature Neuroscience 2022
Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis
C Figueroa-Romero, A Monteagudo, B Murdock, J Famie, I Webber-Davis, C Piecuch, S Teener, C Pacut, S Goutman, E Feldman
Frontiers in immunology 2022
Insights into the identification of a molecular signature for amyotrophic lateral sclerosis exploiting integrated microRNA profiling of iPSC-derived motor neurons and exosomes.
Rizzuti M, Melzi V, Gagliardi D, Resnati D, Meneri M, Dioni L, Masrori P, Hersmus N, Poesen K, Locatelli M, Biella F, Silipigni R, Bollati V, Bresolin N, Comi GP, Van Damme P, Nizzardo M, Corti S
Cellular and molecular life sciences : CMLS 2022
Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4.
Campisi L, Chizari S, Ho JSY, Gromova A, Arnold F, Mosca L, Mei X, Fstkchyan Y, Torre D, Beharry C, Garcia-Forn M, Jiménez-Alcázar M, Korobeynikov VA, Prazich J, Fayad ZA, Seldin MM, De Rubeis S, Bennett CL, Ostrow LW, Lunetta C, Squatrito M, Byun M, Shneider NA, Jiang N, La Spada AR, Marazzi I
Nature 2022
Identification of let-7f and miR-338 as plasma-based biomarkers for sporadic amyotrophic lateral sclerosis using meta-analysis and empirical validation.
Daneshafrooz N, Joghataei MT, Mehdizadeh M, Alavi A, Barati M, Panahi B, Teimourian S, Zamani B
Scientific Reports 2022
Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model
Xue YC, Liu H, Mohamud Y, Bahreyni A, Zhang J, Cashman NR, Luo H
Journal of Neuroinflammation 2022
A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men
Martin S, Battistini C, Sun J
Frontiers in Cellular and Infection Microbiology 2022
Phase 2B randomized controlled trial of NP001 in amyotrophic lateral sclerosis: Pre‐specified and post hoc analyses
Miller RG, Zhang R, Bracci PM, Azhir A, Barohn R, Bedlack R, Benatar M, Berry JD, Cudkowicz M, Kasarskis EJ, Mitsumoto H, Manousakis G, Walk D, Oskarsson B, Shefner J, McGrath MS
Muscle & Nerve 2022
Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice
Trolese MC, Scarpa C, Melfi V, Fabbrizio P, Sironi F, Rossi M, Bendotti C, Nardo G
Molecular Therapy 2022
Psychological stress induces depressive-like behavior associated with bone marrow-derived monocyte infiltration into the hippocampus independent of blood–brain barrier disruption
Hu H, Yang X, He Y, Duan C, Sun N
Journal of Neuroinflammation 2022
The heterogeneity of microglial activation and its epigenetic and non-coding RNA regulations in the immunopathogenesis of neurodegenerative diseases.
Li C, Ren J, Zhang M, Wang H, Yi F, Wu J, Tang Y
Cellular and molecular life sciences : CMLS 2022
Motoneuron Diseases.
Lotti F, Przedborski S
Advances in Neurobiology 2022
Motor neuron disease in a patient with overlap syndrome (rheumatoid arthritis; systemic lupus erythematosus, Sjogren’s syndrome)
Atalar E, Yurdakul FG, Gök K, Güler T, Erten Ş, Yaşar E, Bodur H
Rheumatology International 2022
Current Advancement of Immunomodulatory Drugs as Potential Pharmacotherapies for Autoimmunity Based Neurological Diseases
Ashraf H, Solla P, Sechi LA
Pharmaceuticals 2022
Status of ALS Treatment, Insights into Therapeutic Challenges and Dilemmas.
Khamaysa M, Pradat PF
Journal of Personalized Medicine 2022
The Potential Role of Cytotoxic Immune Effectors in Induction, Progression and Pathogenesis of Amyotrophic Lateral Sclerosis (ALS).
Kaur K, Chen PC, Ko MW, Mei A, Chovatiya N, Huerta-Yepez S, Ni W, Mackay S, Zhou J, Maharaj D, Malarkannan S, Jewett A
Cells 2022
Analysis of shared underlying mechanism in neurodegenerative disease
Butler R, Bradford D, Rodgers KE
Frontiers in aging neuroscience 2022
Patching Up the Permeability: The Role of Stem Cells in Lessening Neurovascular Damage in Amyotrophic Lateral Sclerosis
Monsour M, Garbuzova-Davis S, Borlongan CV
Stem Cells Translational Medicine 2022
Role and Dysregulation of miRNA in Patients with Parkinson’s Disease
Salemi M, Marchese G, Lanza G, Cosentino FI, Salluzzo MG, Schillaci FA, Ventola GM, Cordella A, Ravo M, Ferri R
International journal of molecular sciences 2022
Sex Differences in Adipose Tissue Distribution Determine Susceptibility to Neuroinflammation in Mice With Dietary Obesity
Stranahan AM, Guo DH, Yamamoto M, Hernandez CM, Khodadadi H, Baban B, Zhi W, Lei Y, Lu X, Ding K, Isales CM
Diabetes 2022
NK cells associate with ALS severity in a sex- and age-dependent manner
Benjamin J Murdock, Joshua P Famie, Caroline E Piecuch, Kristen D Raue, Faye E Mendelson, Cole H Pieroni, Sebastian D Iniguez, Lili Zhao, Stephen A Goutman, Eva L. Feldman
JCI Insight 2021
Regulation of splenic monocyte homeostasis and function by gut microbial products
P Kolypetri, S Liu, LM Cox, M Fujiwara, R Raheja, D Ghitza, A Song, D Daatselaar, V Willocq, HL Weiner
iScience 2021
Network Analysis Identifies Sex-Specific Gene Expression Changes in Blood of Amyotrophic Lateral Sclerosis Patients
JA Santiago, JP Quinn, JA Potashkin
International journal of molecular sciences 2021
Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead
J Lake, CS Storm, MB Makarious, S Bandres-Ciga
Cells 2021
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
AG Spiteri, CL Wishart, R Pamphlett, G Locatelli, NJ King
Acta Neuropathologica 2021
Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact
FD Marchi, I Munitic, A Amedei, JD Berry, EL Feldman, E Aronica, G Nardo, DV Weehaeghe, E Niccolai, N Prtenjaca, SA Sakowski, C Bendotti, L Mazzini
Neuroscience and biobehavioral reviews 2021
Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers
BF Vahsen, E Gray, AG Thompson, O Ansorge, DC Anthony, SA Cowley, K Talbot, MR Turner
Nature Reviews Neurology 2021
Immune Response in Neurological Pathology: Emerging Role of Central and Peripheral Immune Crosstalk
AP Passaro, AL Lebos, Y Yao, SL Stice
Frontiers in immunology 2021
Microglia in neurodegenerative diseases
Y Xu, MZ Jin, ZY Yang, WL Jin
NEURAL REGEN RES 2021
Microglia Morphological Changes in the Motor Cortex of hSOD1G93A Transgenic ALS Mice
S Migliarini, S Scaricamazza, C Valle, A Ferri, M Pasqualetti, E Ferraro
Brain Sciences 2021
Human Monocytes Plasticity in Neurodegeneration
I Savinetti, A Papagna, M Foti
Biomedicines 2021
The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS
M Kovacs, C Alamón, C Maciel, V Varela, S Ibarburu, L Tarragó, PH King, Y Si, Y Kwon, O Hermine, L Barbeito, E Trias
Acta Neuropathologica Communications 2021
Amyotrophic lateral sclerosis patients show increased peripheral and intrathecal T-cell activation
L Rolfes, A Schulte-Mecklenbeck, S Schreiber, S Vielhaber, M Herty, A Marten, S Pfeuffer, T Ruck, H Wiendl, CC Gross, SG Meuth, M Boentert, M Pawlitzki
2021
Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis
PA Piec, V Pons, S Rivest
Cells 2021
HIV Tat-Mediated Induction of Monocyte Transmigration Across the Blood–Brain Barrier: Role of Chemokine Receptor CXCR3
F Niu, K Liao, G Hu, S Moidunny, S Roy, S Buch
Frontiers in Cell and Developmental Biology 2021
RNA Deregulation in Amyotrophic Lateral Sclerosis: The Noncoding Perspective
P Laneve, P Tollis, E Caffarelli
International journal of molecular sciences 2021
Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons
M Barbosa, C Gomes, C Sequeira, J Gonçalves-Ribeiro, CC Pina, LA Carvalho, R Moreira, SH Vaz, AR Vaz, D Brites
Frontiers in Cell and Developmental Biology 2021
Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
DH Guo, M Yamamoto, CM Hernandez, H Khodadadi, B Baban, AM Stranahan
Nature Communications 2021
Evaluation of Peripheral Immune Activation in Amyotrophic Lateral Sclerosis
M Wang, Z Liu, J Du, Y Yuan, B Jiao, X Zhang, X Hou, L Shen, J Guo, H Jiang, K Xia, J Tang, R Zhang, B Tang, J Wang
Frontiers in neurology 2021
Neuroinflammation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia and the Interest of Induced Pluripotent Stem Cells to Study Immune Cells Interactions With Neurons
E Liu, L Karpf, D Bohl
Frontiers in molecular neuroscience 2021
The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations
del Pilar C, Lebrón-Galán R, Pérez-Martín E, Pérez-Revuelta L, Ávila-Zarza CA, Alonso JR, Clemente D, Weruaga E, Díaz D
Frontiers in cellular neuroscience 2021
A new method for obtaining bankable and expandable adult-like microglia in mice.
You MJ, Rim C, Kang YJ, Kwon MS
Journal of Neuroinflammation 2021
Splenic Ly6Chi monocytes are critical players in dystrophic muscle injury and repair
Giuseppe Rizzo, Rosanna Di Maggio, Anna Benedetti, Jacopo Morroni, Marina Bouche, Biliana Lozanoska-Ochser
JCI Insight 2020
Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation
Soumyadeep Dey, Zhenzhong Cui, Oksana Gavrilova, XiaoJie Zhang, Max Gassmann, Constance T. Noguchi
JCI Insight 2020
Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons
Silvia Pozzi, Philippe Codron, Genevieve Soucy, Laurence Renaud, Pierre Cordeau, Kallol Dutta, Christine Bareil, Jean-Pierre Julien
JCI Insight 2020
Immunity in amyotrophic lateral sclerosis: blurred lines between excessive inflammation and inefficient immune responses
LC Béland, A Markovinovic, H Jakovac, FD Marchi, E Bilic, L Mazzini, J Kriz, I Munitic
2020
Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival
A Chiot, S Zaïdi, C Iltis, M Ribon, F Berriat, L Schiaffino, A Jolly, P de la Grange, M Mallat, D Bohl, S Millecamps, D Seilhean, CS Lobsiger, S Boillée
Nature Neuroscience 2020
Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis
E Christoforidou, G Joilin, M Hafezparast
Journal of Neuroinflammation 2020
Analysis of ALS-related proteins during herpes simplex virus-2 latent infection
JR Cabrera, I Rodríguez-Izquierdo, JL Jiménez, MÁ Muñoz-Fernández
Journal of Neuroinflammation 2020
Microglia, Lifestyle Stress, and Neurodegeneration
C Madore, Z Yin, J Leibowitz, O Butovsky
Immunity 2020
Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis
RB McGill, FJ Steyn, ST Ngo, KA Thorpe, S Heggie, MJ Ruitenberg, RD Henderson, PA McCombe, TM Woodruff
2020
The Peripheral Immune System and Amyotrophic Lateral Sclerosis
PA McCombe, JD Lee, TM Woodruff, RD Henderson
Frontiers in neurology 2020
An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease
SA Banack, RA Dunlop, PA Cox
Open Biology 2020
Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial
W Camu, M Mickunas, JL Veyrune, C Payan, C Garlanda, M Locati, R Juntas-Morales, N Pageot, A Malaspina, U Andreasson, J Kirby, C Suehs, S Saker, C Masseguin, JD Vos, H Zetterberg, PJ Shaw, A Al-Chalabi, PN Leigh, T Tree, G Bensimon
EBioMedicine 2020
Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients
KY Kim, YR Kim, KW Choi, M Lee, S Lee, W Im, JY Shin, JY Kim, YH Hong, M Kim, JI Kim, JJ Sung
Translational Neurodegeneration 2020
Circulating Inflammatory miRNAs Associated with Parkinson’s Disease Pathophysiology
SR Oliveira, PA Dionísio, LC Guedes, N Gonçalves, M Coelho, MM Rosa, JD Amaral, JJ Ferreira, CM Rodrigues
Biomolecules 2020
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
AM Jurga, M Paleczna, KZ Kuter
Frontiers in cellular neuroscience 2020
Emerging Developments in Human Induced Pluripotent Stem Cell-Derived Microglia: Implications for Modelling Psychiatric Disorders With a Neurodevelopmental Origin
B Hanger, A Couch, L Rajendran, DP Srivastava, AC Vernon
Frontiers in Psychiatry 2020
Heterogeneity of Neuroinflammatory Responses in Amyotrophic Lateral Sclerosis: A Challenge or an Opportunity?
G Cipollina, AD Serej, GD Nolfi, A Gazzano, A Marsala, MG Spatafora, M Peviani
International journal of molecular sciences 2020
The Expanding Cell Diversity of the Brain Vasculature
JM Ross, C Kim, D Allen, EE Crouch, K Narsinh, DL Cooke, AA Abla, TJ Nowakowski, EA Winkler
Frontiers in physiology 2020
IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
MR Strickland, KR Ibanez, M Yaroshenko, CC Diaz, DR Borchelt, P Chakrabarty
Scientific Reports 2020
Transcriptomic characterization of microglia activation in a rat model of ischemic stroke
W Deng, E Mandeville, Y Terasaki, W Li, J Holder, AT Chuang, M Ning, K Arai, EH Lo, C Xing
Journal of Cerebral Blood Flow & Metabolism 2020
Peripheral and Central Nervous System Immune Response Crosstalk in Amyotrophic Lateral Sclerosis
Z Liu, , S Zhong, X Zhang, C Liu, F Liu, C Zhao
Frontiers in neuroscience 2020
Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
W Zhao, DR Beers, JR Thonhoff, AD Thome, A Faridar, J Wang, S Wen, L Ornelas, D Sareen, HS Goodridge, CN Svendsen, SH Appel
iScience 2020
A compound downregulation of SRRM2 and miR-27a-3p with upregulation of miR-27b-3p in PBMCs of Parkinson’s patients is associated with the early stage onset of disease
S Fazeli, M Motovali-Bashi, M Peymani, MS Hashemi, M Etemadifar, MH Nasr-Esfahani, K Ghaedi, H Ariga
PloS one 2020
Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment
ML Calió, E Henriques, A Siena, CR Bertoncini, J Gil-Mohapel, TR Rosenstock
Frontiers in neuroscience 2020
Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson's Disease.
Rui W, Li S, Xiao H, Xiao M, Shi J
The International Journal of Neuropsychopharmacology 2020
Circulating RNAs as Potential Biomarkers in Amyotrophic Lateral Sclerosis
Ravnik-Glavač M, Glavač D
International journal of molecular sciences 2020
CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice
Komiya H, Takeuchi H, Ogawa Y, Hatooka Y, Takahashi K, Katsumoto A, Kubota S, Nakamura H, Kunii M, Tada M, Doi H, Tanaka F
Molecular brain 2020
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders
Y Espinosa-Parrilla, C Gonzalez-Billault, E Fuentes, I Palomo, M Alarcón
Frontiers in aging neuroscience 2019
Macrophages at CNS interfaces: ontogeny and function in health and disease
K Kierdorf, T Masuda, MJ Jordão, M Prinz
Nature Reviews Neuroscience 2019
Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction
TD Arnold, CO Lizama, KM Cautivo, N Santander, L Lin, H Qiu, EJ Huang, C Liu, Y Mukouyama, LF Reichardt, AC Zovein, D Sheppard
Journal of Experimental Medicine 2019
ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia
WR Swindell, CP Kruse, EO List, DE Berryman, JJ Kopchick
Journal of Translational Medicine 2019
A Systematic Review of Suggested Molecular Strata, Biomarkers and Their Tissue Sources in ALS
UG Vijayakumar, V Milla, MY Stafford, AJ Bjourson, W Duddy, SM Duguez
Frontiers in neurology 2019
Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases
NP Staff, DT Jones, W Singer
Mayo Clinic Proceedings 2019
Small Non-coding RNAs: New Class of Biomarkers and Potential Therapeutic Targets in Neurodegenerative Disease
CN Watson, A Belli, VD Pietro
Frontiers in Genetics 2019
Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases
T Hosaka, T Yamashita, A Tamaoka, S Kwak
International journal of molecular sciences 2019
Immunologic Alterations Associated With Oral Delivery of Anti-CD3 (OKT3) Monoclonal Antibodies in Patients With Moderate-to-Severe Ulcerative Colitis
EK Boden, JB Canavan, CJ Moran, K McCann, WA Dunn, FA Farraye, AN Ananthakrishnan, V Yajnik, R Gandhi, DD Nguyen, AK Bhan, HL Weiner, JR Korzenik, SB Snapper
2019
Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome
D Tejera, D Mercan, JM SanchezCaro, M Hanan, D Greenberg, H Soreq, E Latz, D Golenbock, MT Heneka
The EMBO Journal 2019
CD34 Identifies a Subset of Proliferating Microglial Cells Associated with Degenerating Motor Neurons in ALS
M Kovacs, E Trias, V Varela, S Ibarburu, JS Beckman, IC Moura, O Hermine, PH King, Y Si, Y Kwon, L Barbeito
International journal of molecular sciences 2019
MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
JH Jara, M Gautam, N Kocak, EF Xie, Q Mao, EH Bigio, PH Özdinler
Journal of Neuroinflammation 2019
Occurrence of Transmembrane Protein 119 in the Retina is Not Restricted to the Microglia: An Immunohistochemical Study
N Su, S März, T Plagemann, J Cao, HJ Schnittler, N Eter, P Heiduschka
Translational Vision Science & Technology 2019
Microglia: Methods and Protocols
O Garaschuk, A Verkhratsky
2019
Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice
C Figueroa-Romero, K Guo, BJ Murdock, X Paez-Colasante, CM Bassis, KA Mikhail, KD Raue, MC Evans, GF Taubman, AJ McDermott, PD O'Brien, MG Savelieff, J Hur, EL Feldman
Disease models & mechanisms 2019
How to reprogram microglia toward beneficial functions: How to reprogram microglia toward beneficial functions
M Fumagalli, M Lombardi, P Gressens, C Verderio
Glia 2018
Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan
TL Tay, C Béchade, I DAndrea, MK St-Pierre, MS Henry, A Roumier, ME Tremblay
Frontiers in molecular neuroscience 2018
Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis
C Rossi, M Cusimano, M Zambito, A Finardi, A Capotondo, JM Garcia-Manteiga, G Comi, R Furlan, G Martino, L Muzio
Cell Death and Disease 2018
Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes
O Komine, H Yamashita, N Fujimori-Tonou, M Koike, S Jin, Y Moriwaki, F Endo, S Watanabe, S Uematsu, S Akira, Y Uchiyama, R Takahashi, H Misawa, K Yamanaka
Cell Death and Differentiation 2018
Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease
AS Harms, AD Thome, Z Yan, AM Schonhoff, GP Williams, X Li, Y Liu, H Qin, EN Benveniste, DG Standaert
Experimental Neurology 2018
The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets
S Mammana, P Fagone, E Cavalli, M Basile, M Petralia, F Nicoletti, P Bramanti, E Mazzon
International journal of molecular sciences 2018
Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice
K Pfuhlmann, SC Schriever, B Legutko, P Baumann, L Harrison, DG Kabra, EV Baumgart, MH Tschöp, C Garcia-Caceres, PT Pfluger
Journal of Neuroinflammation 2018
Integrated imaging of [11C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy 1H-MRS in amyotrophic lateral sclerosis
EM Ratai, MJ Alshikho, NR Zürcher, ML Loggia, CL Cebulla, P Cernasov, B Reynolds, J Fish, R Seth, S Babu, S Paganoni, JM Hooker, N Atassi
NeuroImage: Clinical 2018
Integrated magnetic resonance imaging and [ 11 C]-PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis: Integrated MRI and PET in ALS
MJ Alshikho, NR Zürcher, ML Loggia, P Cernasov, B Reynolds, O Pijanowski, DB Chonde, DI Garcia, C Mainero, C Catana, J Chan, S Babu, S Paganoni, JM Hooker, N Atassi
Annals of Neurology 2018
Macro roles for microRNAs in neurodegenerative diseases
D Rajgor
Non-coding RNA Research 2018
Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer’s disease-related memory loss in senescence-accelerated prone 8 (SAMP8) mice fed a high-fat diet
Y Kobayashi, H Inagawa, C Kohchi, K Kazumura, H Tsuchiya, T Miwa, K Okazaki, GI Soma, K Abe
PloS one 2018
Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD
H Chen, MW Kankel, SC Su, SW Han, D Ofengeim
Cell Death and Differentiation 2018
Wide-Ranging Analysis of MicroRNA Profiles in Sporadic Amyotrophic Lateral Sclerosis Using Next-Generation Sequencing
BD Felice, F Manfellotto, G Fiorentino, A Annunziata, E Biffali, R Pannone, A Federico
Frontiers in Genetics 2018
TDP43 and RNA instability in amyotrophic lateral sclerosis
K Weskamp, SJ Barmada
Brain Research 2018
Microglial signatures and their role in health and disease
O Butovsky, HL Weiner
Nature Reviews Neuroscience 2018
Differential Expression of Several miRNAs and the Host Genes AATK and DNM2 in Leukocytes of Sporadic ALS Patients
K Vrabec, E Boštjančič, B Koritnik, L Leonardis, LD Grošelj, J Zidar, B Rogelj, D Glavač, M Ravnik-Glavač
Frontiers in molecular neuroscience 2018
Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
JC Cronk, AJ Filiano, A Louveau, I Marin, R Marsh, E Ji, DH Goldman, I Smirnov, N Geraci, S Acton, CC Overall, J Kipnis
Journal of Experimental Medicine 2018
A Brief History of Microglial Ultrastructure: Distinctive Features, Phenotypes, and Functions Discovered Over the Past 60 Years by Electron Microscopy
JC Savage, K Picard, F González-Ibáñez, MÈ Tremblay
Frontiers in immunology 2018
Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis
JH Lee, JW Liu, SZ Lin, HJ Harn, TW Chiou
Cell Transplantation 2018
Role of viruses, prions and miRNA in neurodegenerative disorders and dementia
SS Sohrab, M Suhail, A Ali, MA Kamal, A Husen, F Ahmad, EI Azhar, NH Greig
VirusDisease 2018
MicroRNAs of microglia: Wrestling with central nervous system disease
XH Wang, TL Wang
NEURAL REGEN RES 2018
Acute microglia ablation induces neurodegeneration in the somatosensory system
SJ Rubino, L Mayo, I Wimmer, V Siedler, F Brunner, S Hametner, A Madi, A Lanser, T Moreira, D Donnelly, L Cox, RM Rezende, O Butovsky, H Lassmann, HL Weiner
Nature Communications 2018
A pilot trial of RNS60 in amyotrophic lateral sclerosis: RNS60 Pilot Trial in ALS
S Paganoni, MJ Alshikho, S Luppino, J Chan, L Pothier, D Schoenfeld, PL Andres, S Babu, NR Zürcher, ML Loggia, RL Barry, S Luotti, G Nardo, MC Trolese, S Pantalone, C Bendotti, V Bonetto, FD Marchi, B Rosen, J Hooker, M Cudkowicz, N Atassi
Muscle & Nerve 2018
MicroRNAs as Biomarkers in Amyotrophic Lateral Sclerosis
C Ricci, C Marzocchi, S Battistini
Cells 2018
SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis
AZ Herskovits, TA Hunter, N Maxwell, K Pereira, CA Whittaker, G Valdez, LP Guarente
Aging Cell 2018
The Role of MicroRNAs in Patients with Amyotrophic Lateral Sclerosis.
Dardiotis E, Aloizou AM, Siokas V, Patrinos GP, Deretzi G, Mitsias P, Aschner M, Tsatsakis A
Journal of molecular neuroscience : MN 2018
Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS
Emiliano Trias, Sofia Ibarburu, Romina Barreto-Núñez, Valentina Varela, Ivan Moura, Patrice DUBREUIL, Olivier Hermine, Joseph S. Beckman, Luis Barbeito
JCI Insight 2017
Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis
SG Crisafulli, S Brajkovic, MS Mis, V Parente, S Corti
Molecular Neurobiology 2017
Disruption of the ATP/adenosine balance in CD39 −/− mice is associated with handling-induced seizures
AJ Lanser, RM Rezende, S Rubino, PJ Lorello, DJ Donnelly, H Xu, LA Lau, CG Dulla, BJ Caldarone, SC Robson, HL Weiner
Immunology 2017
Differential contribution of microglia and monocytes in neurodegenerative diseases
C Baufeld, E OLoughlin, N Calcagno, C Madore, O Butovsky
Journal of Neural Transmission 2017
Tumor Necrosis Factor Alpha-Induced Recruitment of Inflammatory Mononuclear Cells Leads to Inflammation and Altered Brain Development in Murine Cytomegalovirus-Infected Newborn Mice
MC Seleme, K Kosmac, S Jonjic, WJ Britt, K Frueh
Journal of virology 2017
Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility
M Valdearcos, JD Douglass, MM Robblee, MD Dorfman, DR Stifler, ML Bennett, I Gerritse, R Fasnacht, BA Barres, JP Thaler, SK Koliwad
Cell Metabolism 2017
Myeloid Cells in the Central Nervous System
J Herz, AJ Filiano, A Smith, N Yogev, J Kipnis
Immunity 2017
MotomiRs: miRNAs in Motor Neuron Function and Disease
ZC Hawley, DC PhD, CA PhD, MJ Strong
Frontiers in molecular neuroscience 2017
Microglia Function in the Central Nervous System During Health and Neurodegeneration
M Colonna, O Butovsky
Annual Review of Immunology 2017
Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling
YW Kwon, SY Cheon, SY Park, J Song, JH Lee
Frontiers in cellular neuroscience 2017
Additive amelioration of ALS by co-targeting independent pathogenic mechanisms
AE Frakes, L Braun, L Ferraiuolo, DC Guttridge, BK Kaspar
Annals of Clinical and Translational Neurology 2017
Differentiation of human and murine induced pluripotent stem cells to microglia-like cells
H Pandya, MJ Shen, DM Ichikawa, AB Sedlock, Y Choi, KR Johnson, G Kim, MA Brown, AG Elkahloun, D Maric, CL Sweeney, S Gossa, HL Malech, DB McGavern, JK Park
Nature Neuroscience 2017
Bone Marrow-Derived Cell Accumulation in the Spinal Cord Is Independent of Peripheral Mobilization in a Mouse Model of Amyotrophic Lateral Sclerosis
K Peake, J Manning, CA Lewis, K Tran, F Rossi, C Krieger
Frontiers in neurology 2017
Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis
HA Wang, JD Lee, KM Lee, TM Woodruff, PG Noakes
Skeletal Muscle 2017
Evidence for an early innate immune response in the motor cortex of ALS
JH Jara, B Genç, MJ Stanford, P Pytel, RP Roos, S Weintraub, MM Mesulam, EH Bigio, RJ Miller, PH Özdinler
Journal of Neuroinflammation 2017
Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis
MP Gustafson, NP Staff, S Bornschlegl, GW Butler, ML Maas, M Kazamel, A Zubair, DA Gastineau, AJ Windebank, AB Dietz, C Raoul
PloS one 2017
Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies
H Lund, M Pieber, RA Harris
Frontiers in aging neuroscience 2017
P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia
P Fabbrizio, S Amadio, S Apolloni, C Volonté
Frontiers in cellular neuroscience 2017
Genetic Association between Amyotrophic Lateral Sclerosis and Cancer
Y Taguchi, H Wang
Genes & development 2017
Splitting the “Unsplittable”: Dissecting Resident and Infiltrating Macrophages in Experimental Autoimmune Encephalomyelitis
T Koeniger, S Kuerten
International journal of molecular sciences 2017
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
S Krasemann, C Madore, R Cialic, C Baufeld, N Calcagno, RE Fatimy, L Beckers, E OLoughlin, Y Xu, Z Fanek, DJ Greco, ST Smith, G Tweet, Z Humulock, T Zrzavy, P Conde-Sanroman, M Gacias, Z Weng, H Chen, E Tjon, F Mazaheri, K Hartmann, A Madi, JD Ulrich, M Glatzel, A Worthmann, J Heeren, B Budnik, C Lemere, T Ikezu, FL Heppner, V Litvak, DM Holtzman, H Lassmann, HL Weiner, J Ochando, C Haass, O Butovsky
Immunity 2017
Inflammatory role of dendritic cells in Amyotrophic Lateral Sclerosis revealed by an analysis of patients’ peripheral blood
M Rusconi, F Gerardi, W Santus, A Lizio, VA Sansone, C Lunetta, I Zanoni, F Granucci
Scientific Reports 2017
Inflammatory and non-inflammatory monocytes as novel prognostic biomarkers of survival in SOD1G93A mouse model of Amyotrophic Lateral Sclerosis
S Gasco, P Zaragoza, A García-Redondo, AC Calvo, R Osta, A Musaro
PloS one 2017
Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model
A Fellner, Y Barhum, A Angel, N Perets, I Steiner, D Offen, N Lev
International journal of molecular sciences 2017
Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications
J Liu, F Wang
Frontiers in immunology 2017
Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability: Fingolimod in ALS
JD Berry, S Paganoni, N Atassi, EA Macklin, N Goyal, M Rivner, E Simpson, S Appel, DL Grasso, NI Mejia, F Mateen, A Gill, F Vieira, V Tassinari, S Perrin
Muscle & Nerve 2017
Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina
P Hu, NH Hunt, F Arfuso, LC Shaw, MN Uddin, M Zhu, R Devasahayam, SJ Adamson, VL Benson, T Chan-Ling, MB Grant
Investigative ophthalmology & visual science 2017
Pharmacological inhibition of complement C5a-C5a 1 receptor signalling ameliorates disease pathology in the hSOD1 G93A mouse model of amyotrophic lateral sclerosis: C5a 1 receptor antagonism is protective in ALS mice
JD Lee, V Kumar, JN Fung, MJ Ruitenberg, PG Noakes, TM Woodruff
British Journal of Pharmacology 2017
The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis
G Chiarotto, G Nardo, M Trolese, M França, C Bendotti, AR de Oliveira
International journal of molecular sciences 2017
Lack of SOCS3 increases LPS-induced murine acute lung injury through modulation of Ly6C(+) macrophages
Z Jiang, Z Chen, L Li, W Zhou, L Zhu
Respiratory Research 2017
Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
W Zhao, DR Beers, KG Hooten, DH Sieglaff, A Zhang, S Kalyana-Sundaram, CM Traini, WS Halsey, AM Hughes, GM Sathe, GP Livi, GH Fan, SH Appel
JAMA NEUROL 2017
Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression
BJ Murdock, T Zhou, SR Kashlan, RJ Little, SA Goutman, EL Feldman
JAMA NEUROL 2017
Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry
E Martin, M El-Behi, B Fontaine, C Delarasse
Journal of visualized experiments : JoVE 2017
MicroRNA Metabolism and Dysregulation in Amyotrophic Lateral Sclerosis.
Rinchetti P, Rizzuti M, Faravelli I, Corti S
Molecular Neurobiology 2017
Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.
Cunha C, Santos C, Gomes C, Fernandes A, Correia AM, Sebastião AM, Vaz AR, Brites D
Molecular Neurobiology 2017
Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis
E Trias, S Ibarburu, R Barreto-Núñez, J Babdor, TT Maciel, M Guillo, L Gros, P Dubreuil, P Díaz-Amarilla, P Cassina, L Martínez-Palma, IC Moura, JS Beckman, O Hermine, L Barbeito
Journal of Neuroinflammation 2016
Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery
C Xing, EH Lo
Progress in Neurobiology 2016
Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors
JE Anttila, KW Whitaker, ES Wires, BK Harvey, M Airavaara
Progress in Neuro-Psychopharmacology and Biological Psychiatry 2016
Inflammatory Disequilibrium in Stroke
D Petrovic-Djergovic, SN Goonewardena, DJ Pinsky
Circulation research 2016
Reduction of cytosolic phospholipase A2α upregulation delays the onset of symptoms in SOD1G93A mouse model of amyotrophic lateral sclerosis
Y Solomonov, N Hadad, R Levy
Journal of Neuroinflammation 2016
Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target
L Du, Y Zhang, Y Chen, J Zhu, Y Yang, HL Zhang
Molecular Neurobiology 2016
Dark microglia: A new phenotype predominantly associated with pathological states: A New Microglial Phenotype
K Bisht, KP Sharma, C Lecours, MG Sánchez, HE Hajj, G Milior, A Olmos-Alonso, D Gómez-Nicola, G Luheshi, L Vallières, I Branchi, L Maggi, C Limatola, O Butovsky, MÈ Tremblay
Glia 2016
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease
AD Thome, AS Harms, LA Volpicelli-Daley, DG Standaert
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms
C Figueroa-Romero, J Hur, JS Lunn, X Paez-Colasante, DE Bender, R Yung, SA Sakowski, EL Feldman
Molecular and Cellular Neuroscience 2016
The retinal pigment epithelium as a gateway for monocyte trafficking into the eye
I Benhar, K Reemst, V Kalchenko, M Schwartz
The EMBO Journal 2016
Control of the Inflammatory Macrophage Transcriptional Signature by miR-155
KA Jablonski, AD Gaudet, SA Amici, PG Popovich, M Guerau-de-Arellano, G Zissel
PloS one 2016
Activation of microglia by retroviral infection correlate with transient clearance of prions from the brain but does not change incubation time
C Muth, K Schröck, C Madore, K Hartmann, Z Fanek, O Butovsky, M Glatzel, S Krasemann
Brain Pathology 2016
Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus
NH Varvel, JJ Neher, A Bosch, W Wang, RM Ransohoff, RJ Miller, R Dingledine
Proceedings of the National Academy of Sciences 2016
CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves
A Martínez-Muriana, R Mancuso, I Francos-Quijorna, A Olmos-Alonso, R Osta, VH Perry, X Navarro, D Gomez-Nicola, R López-Vales
Scientific Reports 2016
Non-neuronal Cells in ALS: Role of Glial, Immune cells and Blood-CNS Barriers: Non-Neuronal Cells in ALS
F Puentes, A Malaspina, JM van Noort, S Amor
Brain Pathology 2016
Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders
Y Takahashi, Z Yu, M Sakai, H Tomita
Frontiers in cellular neuroscience 2016
Aberration of miRNAs Expression in Leukocytes from Sporadic Amyotrophic Lateral Sclerosis
YP Chen, QQ Wei, XP Chen, CY Li, B Cao, RW Ou, S Hadano, HF Shang
Frontiers in molecular neuroscience 2016
Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism
F Patin, T Baranek, P Vourch, L Nadal-Desbarats, JF Goossens, S Marouillat, AF Dessein, A Descat, BM Hounoum, C Bruno, H Watier, M Si-Tahar, S Leman, JC Lecron, CR Andres, P Corcia, H Blasco
Neurotherapeutics 2016
Chemical dampening of Ly6Chi monocytes in the periphery produces anti-depressant effects in mice
X Zheng, S Ma, A Kang, M Wu, L Wang, Q Wang, G Wang, H Hao
Scientific Reports 2016
Increased ratio of circulating neutrophils to monocytes in amyotrophic lateral sclerosis
BJ Murdock, DE Bender, SR Kashlan, C Figueroa-Romero, C Backus, BC Callaghan, SA Goutman, EL Feldman
Neurology: Neuroimmunology & Neuroinflammation 2016
The brain parenchyma has a type I interferon response that can limit virus spread
E Drokhlyansky, DG Aytürk, TK Soh, R Chrenek, E OLoughlin, C Madore, O Butovsky, CL Cepko
Proceedings of the National Academy of Sciences 2016
Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms
S Freiesleben, M Hecker, UK Zettl, G Fuellen, L Taher
Scientific Reports 2016
M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b
C Parisi, G Napoli, P Pelegrin, C Volonté
Mediators of Inflammation 2016
Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis
LT Vu, R Bowser
Neurotherapeutics 2016
Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage
M Li, Z Li, H Ren, WN Jin, K Wood, Q Liu, KN Sheth, FD Shi
Journal of Cerebral Blood Flow & Metabolism 2016
Microglia across the lifespan: from origin to function in brain development, plasticity and cognition: Microglia across the lifespan
TL Tay, JC Savage, CW Hui, K Bisht, MÈ Tremblay
The Journal of Physiology 2016
Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture
ZA Miller, VE Sturm, GB Camsari, A Karydas, JS Yokoyama, LT Grinberg, AL Boxer, HJ Rosen, KP Rankin, ML Gorno-Tempini, G Coppola, DH Geschwind, R Rademakers, WW Seeley, NR Graff-Radford, BL Miller
Neurology: Neuroimmunology & Neuroinflammation 2016
Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis
L Pasetto, S Pozzi, M Castelnovo, M Basso, AG Estevez, S Fumagalli, MG Simoni, V Castellaneta, P Bigini, E Restelli, R Chiesa, F Trojsi, MR Monsurrò, L Callea, M Malešević, G Fischer, M Freschi, M Tortarolo, C Bendotti, V Bonetto
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Impaired activation of ALS monocytes by exosomes
L Zondler, MS Feiler, A Freischmidt, WP Ruf, AC Ludolph, KM Danzer, JH Weishaupt
Immunology and Cell Biology 2016
MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease
JR Guedes, I Santana, C Cunha, D Duro, MR Almeida, AM Cardoso, MC de Lima, AL Cardoso
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2015
Immunization with a Myelin-Derived Antigen Activates the Brain's Choroid Plexus for Recruitment of Immunoregulatory Cells to the CNS and Attenuates Disease Progression in a Mouse Model of ALS
G Kunis, K Baruch, O Miller, M Schwartz
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells
J Herz, KR Johnson, DB McGavern
Journal of Experimental Medicine 2015
Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma
A Bosco, CO Romero, KT Breen, AA Chagovetz, MR Steele, BK Ambati, ML Vetter
Disease models & mechanisms 2015
Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice
L Gao, D Brenner, E Llorens-Bobadilla, G Saiz-Castro, T Frank, P Wieghofer, O Hill, M Thiemann, S Karray, M Prinz, JH Weishaupt, A Martin-Villalba
Journal of Experimental Medicine 2015
Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease
Heather E. Allen Reish, David G. Standaert
Journal of Parkinson's disease 2015
Novel Markers to Delineate Murine M1 and M2 Macrophages
KA Jablonski, SA Amici, LM Webb, JD Ruiz-Rosado, PG Popovich, S Partida-Sanchez, M Guerau-de-Arellano, MA Olszewski
PloS one 2015
Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions: ALS & PLS fibroblasts as cell models for sporadic disease
R Raman, SP Allen, EF Goodall, S Kramer, LL Ponger, PR Heath, M Milo, HC Hollinger, T Walsh, JR Highley, S Olpin, CJ McDermott, PJ Shaw, J Kirby
Neuropathology and Applied Neurobiology 2015
Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?
KA Nicholson, ME Cudkowicz, JD Berry
Neurotherapeutics 2015
Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis
KG Hooten, DR Beers, W Zhao, SH Appel
Neurotherapeutics 2015
P2Y12 expression and function in alternatively activated human microglia
CS Moore, AR Ase, A Kinsara, VT Rao, M Michell-Robinson, SY Leong, O Butovsky, SK Ludwin, P Seguela, A Bar-Or, JP Antel
Neurology: Neuroimmunology & Neuroinflammation 2015
Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency: Microglia Signature in Peroxisomal Mfp2 Deficiency
S Verheijden, L Beckers, A Casazza, O Butovsky, M Mazzone, M Baes
Glia 2015
Roles of microglia in brain development, tissue maintenance and repair
MA Michell-Robinson, H Touil, LM Healy, DR Owen, BA Durafourt, A Bar-Or, JP Antel, CS Moore
Brain 2015
Advances in toponomics drug discovery: Imaging cycler microscopy correctly predicts a therapy method of amyotrophic lateral sclerosis: ALS toponome
W Schubert
Cytometry Part A 2015
Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era
X Paez-Colasante, C Figueroa-Romero, SA Sakowski, SA Goutman, EL Feldman
Nature Reviews Neurology 2015
Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS
RG Miller, G Block, JS Katz, RJ Barohn, V Gopalakrishnan, M Cudkowicz, JR Zhang, MS McGrath, E Ludington, SH Appel, A Azhir
Neurology: Neuroimmunology & Neuroinflammation 2015
Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice
P Hu, JS Thinschmidt, S Caballero, S Adamson, L Cole, T Chan-Ling, MB Grant
American journal of physiology. Endocrinology and metabolism 2015
CD4 + T Cells and Neuroprotection: Relevance to Motoneuron Injury and Disease
KJ Jones, AE Lovett-Racke, CL Walker, VM Sanders
Journal of Neuroimmune Pharmacology 2015
Functional differences between microglia and monocytes after ischemic stroke
RM Ritzel, AR Patel, JM Grenier, J Crapser, R Verma, ER Jellison, LD McCullough
Journal of Neuroinflammation 2015
Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus
RA Rice, EE Spangenberg, H Yamate-Morgan, RJ Lee, RP Arora, MX Hernandez, AJ Tenner, BL West, KN Green
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Editorial on the original article entitled "Genetic validation of a therapeutic target in a mouse model of ALS" published in the Science Translational Medicine on August 6, 2014
Vincenzo Silani
Annals of translational medicine 2015
New insights into the multidimensional concept of macrophage ontogeny, activation and function
F Ginhoux, JL Schultze, PJ Murray, J Ochando, SK Biswas
Nature Immunology 2015
Central nervous system myeloid cells as drug targets: current status and translational challenges
K Biber, T Möller, E Boddeke, M Prinz
Nature Reviews Drug Discovery 2015
microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases
I Basak, KS Patil, G Alves, JP Larsen, SG Møller
Cellular and Molecular Life Sciences 2015
Origin of Microglia: Current Concepts and Past Controversies
F Ginhoux, M Prinz
Cold Spring Harbor perspectives in biology 2015
NP001 regulation of macrophage activation markers in ALS: A phase I clinical and biomarker study
RG Miller, R Zhang, G Block, J Katz, R Barohn, E Kasarskis, D Forshew, V Gopalakrishnan, MS McGrath
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2014
Therapeutic inflammatory monocyte modulation using immune-modifying microparticles
DR Getts, RL Terry, MT Getts, C Deffrasnes, M Müller, C Vreden, TM Ashhurst, B Chami, D McCarthy, H Wu, J Ma, A Martin, LD Shae, P Witting, GS Kansas, J Kühn, W Hafezi, IL Campbell, D Reilly, J Say, L Brown, MY White, SJ Cordwell, SJ Chadban, EB Thorp, S Bao, SD Miller, NJ King
Science Translational Medicine 2014
Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
S Apolloni, S Amadio, C Parisi, A Matteucci, RL Potenza, M Armida, P Popoli, N DAmbrosi, C Volonté
Disease models & mechanisms 2014
Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients
V Grozdanov, C Bliederhaeuser, WP Ruf, V Roth, K Fundel-Clemens, L Zondler, D Brenner, A Martin-Villalba, B Hengerer, J Kassubek, AC Ludolph, JH Weishaupt, KM Danzer
Acta Neuropathologica 2014
Glial cells in amyotrophic lateral sclerosis
T Philips, JD Rothstein
Experimental Neurology 2014
The plasticity of inflammatory monocyte responses to the inflamed central nervous system
TM Ashhurst, C van Vreden, P Niewold, NJ King
Cellular Immunology 2014
Microglia centered pathogenesis in ALS: insights in cell interconnectivity
D Brites, AR Vaz
Frontiers in cellular neuroscience 2014
Accelerated Neurodegeneration and Neuroinflammation in Transgenic Mice Expressing P301L Tau Mutant and Tau-Tubulin Kinase 1
H Asai, S Ikezu, ME Woodbury, GM Yonemoto, L Cui, T Ikezu
The American Journal of Pathology 2014
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
M Prinz, J Priller
Nature Reviews Neuroscience 2014
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
AE Frakes, L Ferraiuolo, AM Haidet-Phillips, L Schmelzer, L Braun, CJ Miranda, KJ Ladner, AK Bevan, KD Foust, JP Godbout, PG Popovich, DC Guttridge, BK Kaspar
Neuron 2014
The role of miRNA in motor neuron disease
MJ Kye, IC Gonçalves
Frontiers in cellular neuroscience 2014
Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice: Role of miR-155 in ALS
O Butovsky, MP Jedrychowski, R Cialic, S Krasemann, G Murugaiyan, Z Fanek, DJ Greco, PM Wu, CE Doykan, O Kiner, RJ Lawson, MP Frosch, N Pochet, RE Fatimy, AM Krichevsky, SP Gygi, H Lassmann, J Berry, ME Cudkowicz, HL Weiner
2014
M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?
MS Moehle, AB West
Neuroscience 2014
Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis
S Tada, T Okuno, Y Hitoshi, T Yasui, J Honorat, K Takata, T Koda, H Shimagami, C Chi-Jing, A Namba, T Sugimoto, S Sakoda, H Mochizuki, H Kikutani, Y Nakatsuji
Journal of Neuroinflammation 2014
Use of biomarkers in ALS drug development and clinical trials
N Bakkar, A Boehringer, R Bowser
Brain Research 2014
Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice
JI Ayers, S Fromholt, O Sinyavskaya, Z Siemienski, AM Rosario, A Li, KW Crosby, PE Cruz, NM DiNunno, C Janus, C Ceballos-Diaz, DR Borchelt, TE Golde, P Chakrabarty, Y Levites
Molecular Therapy 2014
MicroRNAs as Potential Circulating Biomarkers for Amyotrophic Lateral Sclerosis
F Cloutier, A Marrero, C O’Connell, PJ Morin
Journal of Molecular Neuroscience 2014
Ontogeny and Functions of Central Nervous System Macrophages
A Katsumoto, H Lu, AS Miranda, RM Ransohoff
Journal of immunology (Baltimore, Md. : 1950) 2014
Circulating miRNAs as Biomarkers for Neurodegenerative Disorders
M Grasso, P Piscopo, A Confaloni, M Denti
Molecules (Basel, Switzerland) 2014
Outcome measures in amyotrophic lateral sclerosis clinical trials.
Paganoni S, Cudkowicz M, Berry JD
Clinical Investigation 2014
Defective inflammatory monocyte development in IRF8-deficient mice abrogates migration to the West Nile virus-infected brain.
Terry RL, Deffrasnes C, Getts DR, Minten C, van Vreden C, Ashhurst TM, Getts MT, Xie RD, Campbell IL, King NJ
Journal of Innate Immunity 2014
Thinking Laterally About Neurodegenerative Proteinopathies
Todd Golde, David Borchelt, benoit giasson, Jada Lewis
Journal of Clinical Investigation 2013
Dramatic Antitumor Effects of the Dual MET/RON Small-Molecule Inhibitor LY2801653 in Non-Small Cell Lung Cancer
I Kawada, R Hasina, Q Arif, J Mueller, E Smithberger, AN Husain, EE Vokes, R Salgia
Cancer research 2013
The changing scene of amyotrophic lateral sclerosis
W Robberecht, T Philips
Nature Reviews Neuroscience 2013
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
ED Koval, C Shaner, P Zhang, X Maine, K Fischer, J Tay, BN Chau, GF Wu, TM Miller
Human Molecular Genetics 2013
Functional diversity of microglia - how heterogeneous are they to begin with?
UK Hanisch
Frontiers in cellular neuroscience 2013
Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair
A London, M Cohen, M Schwartz
Frontiers in cellular neuroscience 2013
Identification of a unique TGF-β-dependent molecular and functional signature in microglia
O Butovsky, MP Jedrychowski, CS Moore, R Cialic, AJ Lanser, G Gabriely, T Koeglsperger, B Dake, PM Wu, CE Doykan, Z Fanek, L Liu, Z Chen, JD Rothstein, RM Ransohoff, SP Gygi, JP Antel, HL Weiner
Nature Neuroscience 2013
The involvement of microRNAs in neurodegenerative diseases
S Maciotta, M Meregalli, Y Torrente
Frontiers in cellular neuroscience 2013
A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
IM Chiu, ET Morimoto, H Goodarzi, JT Liao, S O’Keeffe, HP Phatnani, M Muratet, MC Carroll, S Levy, S Tavazoie, RM Myers, T Maniatis
Cell Reports 2013
Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis
W Zhao, DR Beers, SH Appel
Journal of Neuroimmune Pharmacology 2013
Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis
F Rizzo, G Riboldi, S Salani, M Nizzardo, C Simone, S Corti, E Hedlund
Experientia 2013
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
CS Lobsiger, S Boillee, C Pozniak, AM Khan, M McAlonis-Downes, JW Lewcock, DW Cleveland
Proceedings of the National Academy of Sciences 2013
Microglial Phenotype and Adaptation
BJ Eggen, D Raj, UK Hanisch, HW Boddeke
Journal of Neuroimmune Pharmacology 2013
The multifaceted role of glial cells in amyotrophic lateral sclerosis
CF Valori, L Brambilla, F Martorana, D Rossi
Cellular and Molecular Life Sciences 2013
Minocycline selectively inhibits M1 polarization of microglia
K Kobayashi, S Imagama, T Ohgomori, K Hirano, K Uchimura, K Sakamoto, A Hirakawa, H Takeuchi, A Suzumura, N Ishiguro, K Kadomatsu
Cell Death and Disease 2013
MicroRNAs and Molecular Mechanisms of Neurodegeneration
I Bicchi, F Morena, S Montesano, M Polidoro, S Martino
Genes & development 2013
Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
C Parisi, I Arisi, N D'Ambrosi, AE Storti, R Brandi, M D'Onofrio, C Volonté
Cell Death and Disease 2013
MCP-1/CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS
M Kawaguchi-Niida, T Yamamoto, Y Kato, Y Inose, N Shibata
Acta Neuropathologica Communications 2013
Neuronal dark matter: the emerging role of microRNAs in neurodegeneration
EF Goodall, PR Heath, O Bandmann, J Kirby, PJ Shaw
Frontiers in cellular neuroscience 2013
Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia
SJ Kim, J Li
Cell Death and Disease 2013
Involvement of microRNA in microglia-mediated immune response
J Guedes, AL Cardoso, MC de Lima
Clinical & developmental immunology 2013
Inflammatory monocytes and the pathogenesis of viral encephalitis
RL Terry, DR Getts, C Deffrasnes, C Vreden, IL Campbell, NJ King
Journal of Neuroinflammation 2012
Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis
C Figueroa-Romero, J Hur, DE Bender, CE Delaney, MD Cataldo, AL Smith, R Yung, DM Ruden, BC Callaghan, EL Feldman
PloS one 2012
Motor neuron disease: inflammatory monocytes--a novel therapeutic target for ALS?
Malpass K
Nature reviews. Neurology 2012
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

← Previous 1 2 3 … 11 12 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 1 news outlets
Posted by 6 X users
Referenced in 10 patents
On 1 Facebook pages
Referenced in 1 Wikipedia pages
Mentioned in 1 LinkedIn forums
391 readers on Mendeley
See more details