Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell death that is thought to involve aberrant immune responses. Here we investigated the role of innate immunity in a mouse model of ALS. We found that inflammatory monocytes were activated and that their progressive recruitment to the spinal cord, but not brain, correlated with neuronal loss. We also found a decrease in resident microglia in the spinal cord with disease progression. Prior to disease onset, splenic Ly6Chi monocytes expressed a polarized macrophage phenotype (M1 signature), which included increased levels of chemokine receptor CCR2. As disease onset neared, microglia expressed increased CCL2 and other chemotaxis-associated molecules, which led to the recruitment of monocytes to the CNS by spinal cord–derived microglia. Treatment with anti-Ly6C mAb modulated the Ly6Chi monocyte cytokine profile, reduced monocyte recruitment to the spinal cord, diminished neuronal loss, and extended survival. In humans with ALS, the analogous monocytes (CD14+CD16–) exhibited an ALS-specific microRNA inflammatory signature similar to that observed in the ALS mouse model, linking the animal model and the human disease. Thus, the profile of monocytes in ALS patients may serve as a biomarker for disease stage or progression. Our results suggest that recruitment of inflammatory monocytes plays an important role in disease progression and that modulation of these cells is a potential therapeutic approach.
Oleg Butovsky, Shafiuddin Siddiqui, Galina Gabriely, Amanda J. Lanser, Ben Dake, Gopal Murugaiyan, Camille E. Doykan, Pauline M. Wu, Reddy R. Gali, Lakshmanan K. Iyer, Robert Lawson, James Berry, Anna M. Krichevsky, Merit E. Cudkowicz, Howard L. Weiner
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SR Oliveira, PA Dionísio, LC Guedes, N Gonçalves, M Coelho, MM Rosa, JD Amaral, JJ Ferreira, CM Rodrigues |
Biomolecules | 2020 |
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
AM Jurga, M Paleczna, KZ Kuter |
Frontiers in cellular neuroscience | 2020 |
Emerging Developments in Human Induced Pluripotent Stem Cell-Derived Microglia: Implications for Modelling Psychiatric Disorders With a Neurodevelopmental Origin
B Hanger, A Couch, L Rajendran, DP Srivastava, AC Vernon |
Frontiers in Psychiatry | 2020 |
Heterogeneity of Neuroinflammatory Responses in Amyotrophic Lateral Sclerosis: A Challenge or an Opportunity?
G Cipollina, AD Serej, GD Nolfi, A Gazzano, A Marsala, MG Spatafora, M Peviani |
International journal of molecular sciences | 2020 |
The Expanding Cell Diversity of the Brain Vasculature
JM Ross, C Kim, D Allen, EE Crouch, K Narsinh, DL Cooke, AA Abla, TJ Nowakowski, EA Winkler |
Frontiers in physiology | 2020 |
IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
MR Strickland, KR Ibanez, M Yaroshenko, CC Diaz, DR Borchelt, P Chakrabarty |
Scientific Reports | 2020 |
Transcriptomic characterization of microglia activation in a rat model of ischemic stroke
W Deng, E Mandeville, Y Terasaki, W Li, J Holder, AT Chuang, M Ning, K Arai, EH Lo, C Xing |
Journal of Cerebral Blood Flow & Metabolism | 2020 |
Peripheral and Central Nervous System Immune Response Crosstalk in Amyotrophic Lateral Sclerosis
Z Liu, , S Zhong, X Zhang, C Liu, F Liu, C Zhao |
Frontiers in neuroscience | 2020 |
Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
W Zhao, DR Beers, JR Thonhoff, AD Thome, A Faridar, J Wang, S Wen, L Ornelas, D Sareen, HS Goodridge, CN Svendsen, SH Appel |
iScience | 2020 |
A compound downregulation of SRRM2 and miR-27a-3p with upregulation of miR-27b-3p in PBMCs of Parkinson’s patients is associated with the early stage onset of disease
S Fazeli, M Motovali-Bashi, M Peymani, MS Hashemi, M Etemadifar, MH Nasr-Esfahani, K Ghaedi, H Ariga |
PloS one | 2020 |
Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment
ML Calió, E Henriques, A Siena, CR Bertoncini, J Gil-Mohapel, TR Rosenstock |
Frontiers in neuroscience | 2020 |
Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson's Disease.
Rui W, Li S, Xiao H, Xiao M, Shi J |
The International Journal of Neuropsychopharmacology | 2020 |
Circulating RNAs as Potential Biomarkers in Amyotrophic Lateral Sclerosis
Ravnik-Glavač M, Glavač D |
International journal of molecular sciences | 2020 |
CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice
Komiya H, Takeuchi H, Ogawa Y, Hatooka Y, Takahashi K, Katsumoto A, Kubota S, Nakamura H, Kunii M, Tada M, Doi H, Tanaka F |
Molecular brain | 2020 |
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders
Y Espinosa-Parrilla, C Gonzalez-Billault, E Fuentes, I Palomo, M Alarcón |
Frontiers in aging neuroscience | 2019 |
Macrophages at CNS interfaces: ontogeny and function in health and disease
K Kierdorf, T Masuda, MJ Jordão, M Prinz |
Nature Reviews Neuroscience | 2019 |
Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction
TD Arnold, CO Lizama, KM Cautivo, N Santander, L Lin, H Qiu, EJ Huang, C Liu, Y Mukouyama, LF Reichardt, AC Zovein, D Sheppard |
Journal of Experimental Medicine | 2019 |
ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia
WR Swindell, CP Kruse, EO List, DE Berryman, JJ Kopchick |
Journal of Translational Medicine | 2019 |
A Systematic Review of Suggested Molecular Strata, Biomarkers and Their Tissue Sources in ALS
UG Vijayakumar, V Milla, MY Stafford, AJ Bjourson, W Duddy, SM Duguez |
Frontiers in neurology | 2019 |
Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases
NP Staff, DT Jones, W Singer |
Mayo Clinic Proceedings | 2019 |
Small Non-coding RNAs: New Class of Biomarkers and Potential Therapeutic Targets in Neurodegenerative Disease
CN Watson, A Belli, VD Pietro |
Frontiers in Genetics | 2019 |
Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases
T Hosaka, T Yamashita, A Tamaoka, S Kwak |
International journal of molecular sciences | 2019 |
Immunologic Alterations Associated With Oral Delivery of Anti-CD3 (OKT3) Monoclonal Antibodies in Patients With Moderate-to-Severe Ulcerative Colitis
EK Boden, JB Canavan, CJ Moran, K McCann, WA Dunn, FA Farraye, AN Ananthakrishnan, V Yajnik, R Gandhi, DD Nguyen, AK Bhan, HL Weiner, JR Korzenik, SB Snapper |
2019 | |
Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome
D Tejera, D Mercan, JM SanchezCaro, M Hanan, D Greenberg, H Soreq, E Latz, D Golenbock, MT Heneka |
The EMBO Journal | 2019 |
CD34 Identifies a Subset of Proliferating Microglial Cells Associated with Degenerating Motor Neurons in ALS
M Kovacs, E Trias, V Varela, S Ibarburu, JS Beckman, IC Moura, O Hermine, PH King, Y Si, Y Kwon, L Barbeito |
International journal of molecular sciences | 2019 |
MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
JH Jara, M Gautam, N Kocak, EF Xie, Q Mao, EH Bigio, PH Özdinler |
Journal of Neuroinflammation | 2019 |
Occurrence of Transmembrane Protein 119 in the Retina is Not Restricted to the Microglia: An Immunohistochemical Study
N Su, S März, T Plagemann, J Cao, HJ Schnittler, N Eter, P Heiduschka |
Translational Vision Science & Technology | 2019 |
Microglia: Methods and Protocols
O Garaschuk, A Verkhratsky |
2019 | |
Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice
C Figueroa-Romero, K Guo, BJ Murdock, X Paez-Colasante, CM Bassis, KA Mikhail, KD Raue, MC Evans, GF Taubman, AJ McDermott, PD O'Brien, MG Savelieff, J Hur, EL Feldman |
Disease models & mechanisms | 2019 |
How to reprogram microglia toward beneficial functions: How to reprogram microglia toward beneficial functions
M Fumagalli, M Lombardi, P Gressens, C Verderio |
Glia | 2018 |
Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan
TL Tay, C Béchade, I DAndrea, MK St-Pierre, MS Henry, A Roumier, ME Tremblay |
Frontiers in molecular neuroscience | 2018 |
Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis
C Rossi, M Cusimano, M Zambito, A Finardi, A Capotondo, JM Garcia-Manteiga, G Comi, R Furlan, G Martino, L Muzio |
Cell Death and Disease | 2018 |
Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes
O Komine, H Yamashita, N Fujimori-Tonou, M Koike, S Jin, Y Moriwaki, F Endo, S Watanabe, S Uematsu, S Akira, Y Uchiyama, R Takahashi, H Misawa, K Yamanaka |
Cell Death and Differentiation | 2018 |
Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease
AS Harms, AD Thome, Z Yan, AM Schonhoff, GP Williams, X Li, Y Liu, H Qin, EN Benveniste, DG Standaert |
Experimental Neurology | 2018 |
The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets
S Mammana, P Fagone, E Cavalli, M Basile, M Petralia, F Nicoletti, P Bramanti, E Mazzon |
International journal of molecular sciences | 2018 |
Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice
K Pfuhlmann, SC Schriever, B Legutko, P Baumann, L Harrison, DG Kabra, EV Baumgart, MH Tschöp, C Garcia-Caceres, PT Pfluger |
Journal of Neuroinflammation | 2018 |
Integrated imaging of [11C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy 1H-MRS in amyotrophic lateral sclerosis
EM Ratai, MJ Alshikho, NR Zürcher, ML Loggia, CL Cebulla, P Cernasov, B Reynolds, J Fish, R Seth, S Babu, S Paganoni, JM Hooker, N Atassi |
NeuroImage: Clinical | 2018 |
Integrated magnetic resonance imaging and [ 11 C]-PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis: Integrated MRI and PET in ALS
MJ Alshikho, NR Zürcher, ML Loggia, P Cernasov, B Reynolds, O Pijanowski, DB Chonde, DI Garcia, C Mainero, C Catana, J Chan, S Babu, S Paganoni, JM Hooker, N Atassi |
Annals of Neurology | 2018 |
Macro roles for microRNAs in neurodegenerative diseases
D Rajgor |
Non-coding RNA Research | 2018 |
Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer’s disease-related memory loss in senescence-accelerated prone 8 (SAMP8) mice fed a high-fat diet
Y Kobayashi, H Inagawa, C Kohchi, K Kazumura, H Tsuchiya, T Miwa, K Okazaki, GI Soma, K Abe |
PloS one | 2018 |
Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD
H Chen, MW Kankel, SC Su, SW Han, D Ofengeim |
Cell Death and Differentiation | 2018 |
Wide-Ranging Analysis of MicroRNA Profiles in Sporadic Amyotrophic Lateral Sclerosis Using Next-Generation Sequencing
BD Felice, F Manfellotto, G Fiorentino, A Annunziata, E Biffali, R Pannone, A Federico |
Frontiers in Genetics | 2018 |
TDP43 and RNA instability in amyotrophic lateral sclerosis
K Weskamp, SJ Barmada |
Brain Research | 2018 |
Microglial signatures and their role in health and disease
O Butovsky, HL Weiner |
Nature Reviews Neuroscience | 2018 |
Differential Expression of Several miRNAs and the Host Genes AATK and DNM2 in Leukocytes of Sporadic ALS Patients
K Vrabec, E Boštjančič, B Koritnik, L Leonardis, LD Grošelj, J Zidar, B Rogelj, D Glavač, M Ravnik-Glavač |
Frontiers in molecular neuroscience | 2018 |
Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
JC Cronk, AJ Filiano, A Louveau, I Marin, R Marsh, E Ji, DH Goldman, I Smirnov, N Geraci, S Acton, CC Overall, J Kipnis |
Journal of Experimental Medicine | 2018 |
A Brief History of Microglial Ultrastructure: Distinctive Features, Phenotypes, and Functions Discovered Over the Past 60 Years by Electron Microscopy
JC Savage, K Picard, F González-Ibáñez, MÈ Tremblay |
Frontiers in immunology | 2018 |
Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis
JH Lee, JW Liu, SZ Lin, HJ Harn, TW Chiou |
Cell Transplantation | 2018 |
Role of viruses, prions and miRNA in neurodegenerative disorders and dementia
SS Sohrab, M Suhail, A Ali, MA Kamal, A Husen, F Ahmad, EI Azhar, NH Greig |
VirusDisease | 2018 |
MicroRNAs of microglia: Wrestling with central nervous system disease
XH Wang, TL Wang |
NEURAL REGEN RES | 2018 |
Acute microglia ablation induces neurodegeneration in the somatosensory system
SJ Rubino, L Mayo, I Wimmer, V Siedler, F Brunner, S Hametner, A Madi, A Lanser, T Moreira, D Donnelly, L Cox, RM Rezende, O Butovsky, H Lassmann, HL Weiner |
Nature Communications | 2018 |
A pilot trial of RNS60 in amyotrophic lateral sclerosis: RNS60 Pilot Trial in ALS
S Paganoni, MJ Alshikho, S Luppino, J Chan, L Pothier, D Schoenfeld, PL Andres, S Babu, NR Zürcher, ML Loggia, RL Barry, S Luotti, G Nardo, MC Trolese, S Pantalone, C Bendotti, V Bonetto, FD Marchi, B Rosen, J Hooker, M Cudkowicz, N Atassi |
Muscle & Nerve | 2018 |
MicroRNAs as Biomarkers in Amyotrophic Lateral Sclerosis
C Ricci, C Marzocchi, S Battistini |
Cells | 2018 |
SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis
AZ Herskovits, TA Hunter, N Maxwell, K Pereira, CA Whittaker, G Valdez, LP Guarente |
Aging Cell | 2018 |
The Role of MicroRNAs in Patients with Amyotrophic Lateral Sclerosis.
Dardiotis E, Aloizou AM, Siokas V, Patrinos GP, Deretzi G, Mitsias P, Aschner M, Tsatsakis A |
Journal of molecular neuroscience : MN | 2018 |
Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS
Emiliano Trias, Sofia Ibarburu, Romina Barreto-Núñez, Valentina Varela, Ivan Moura, Patrice DUBREUIL, Olivier Hermine, Joseph S. Beckman, Luis Barbeito |
JCI Insight | 2017 |
Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis
SG Crisafulli, S Brajkovic, MS Mis, V Parente, S Corti |
Molecular Neurobiology | 2017 |
Disruption of the ATP/adenosine balance in CD39 −/− mice is associated with handling-induced seizures
AJ Lanser, RM Rezende, S Rubino, PJ Lorello, DJ Donnelly, H Xu, LA Lau, CG Dulla, BJ Caldarone, SC Robson, HL Weiner |
Immunology | 2017 |
Differential contribution of microglia and monocytes in neurodegenerative diseases
C Baufeld, E OLoughlin, N Calcagno, C Madore, O Butovsky |
Journal of Neural Transmission | 2017 |
Tumor Necrosis Factor Alpha-Induced Recruitment of Inflammatory Mononuclear Cells Leads to Inflammation and Altered Brain Development in Murine Cytomegalovirus-Infected Newborn Mice
MC Seleme, K Kosmac, S Jonjic, WJ Britt, K Frueh |
Journal of virology | 2017 |
Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility
M Valdearcos, JD Douglass, MM Robblee, MD Dorfman, DR Stifler, ML Bennett, I Gerritse, R Fasnacht, BA Barres, JP Thaler, SK Koliwad |
Cell Metabolism | 2017 |
Myeloid Cells in the Central Nervous System
J Herz, AJ Filiano, A Smith, N Yogev, J Kipnis |
Immunity | 2017 |
MotomiRs: miRNAs in Motor Neuron Function and Disease
ZC Hawley, DC PhD, CA PhD, MJ Strong |
Frontiers in molecular neuroscience | 2017 |
Microglia Function in the Central Nervous System During Health and Neurodegeneration
M Colonna, O Butovsky |
Annual Review of Immunology | 2017 |
Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling
YW Kwon, SY Cheon, SY Park, J Song, JH Lee |
Frontiers in cellular neuroscience | 2017 |
Additive amelioration of ALS by co-targeting independent pathogenic mechanisms
AE Frakes, L Braun, L Ferraiuolo, DC Guttridge, BK Kaspar |
Annals of Clinical and Translational Neurology | 2017 |
Differentiation of human and murine induced pluripotent stem cells to microglia-like cells
H Pandya, MJ Shen, DM Ichikawa, AB Sedlock, Y Choi, KR Johnson, G Kim, MA Brown, AG Elkahloun, D Maric, CL Sweeney, S Gossa, HL Malech, DB McGavern, JK Park |
Nature Neuroscience | 2017 |
Bone Marrow-Derived Cell Accumulation in the Spinal Cord Is Independent of Peripheral Mobilization in a Mouse Model of Amyotrophic Lateral Sclerosis
K Peake, J Manning, CA Lewis, K Tran, F Rossi, C Krieger |
Frontiers in neurology | 2017 |
Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis
HA Wang, JD Lee, KM Lee, TM Woodruff, PG Noakes |
Skeletal Muscle | 2017 |
Evidence for an early innate immune response in the motor cortex of ALS
JH Jara, B Genç, MJ Stanford, P Pytel, RP Roos, S Weintraub, MM Mesulam, EH Bigio, RJ Miller, PH Özdinler |
Journal of Neuroinflammation | 2017 |
Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis
MP Gustafson, NP Staff, S Bornschlegl, GW Butler, ML Maas, M Kazamel, A Zubair, DA Gastineau, AJ Windebank, AB Dietz, C Raoul |
PloS one | 2017 |
Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies
H Lund, M Pieber, RA Harris |
Frontiers in aging neuroscience | 2017 |
P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia
P Fabbrizio, S Amadio, S Apolloni, C Volonté |
Frontiers in cellular neuroscience | 2017 |
Genetic Association between Amyotrophic Lateral Sclerosis and Cancer
Y Taguchi, H Wang |
Genes & development | 2017 |
Splitting the “Unsplittable”: Dissecting Resident and Infiltrating Macrophages in Experimental Autoimmune Encephalomyelitis
T Koeniger, S Kuerten |
International journal of molecular sciences | 2017 |
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
S Krasemann, C Madore, R Cialic, C Baufeld, N Calcagno, RE Fatimy, L Beckers, E OLoughlin, Y Xu, Z Fanek, DJ Greco, ST Smith, G Tweet, Z Humulock, T Zrzavy, P Conde-Sanroman, M Gacias, Z Weng, H Chen, E Tjon, F Mazaheri, K Hartmann, A Madi, JD Ulrich, M Glatzel, A Worthmann, J Heeren, B Budnik, C Lemere, T Ikezu, FL Heppner, V Litvak, DM Holtzman, H Lassmann, HL Weiner, J Ochando, C Haass, O Butovsky |
Immunity | 2017 |
Inflammatory role of dendritic cells in Amyotrophic Lateral Sclerosis revealed by an analysis of patients’ peripheral blood
M Rusconi, F Gerardi, W Santus, A Lizio, VA Sansone, C Lunetta, I Zanoni, F Granucci |
Scientific Reports | 2017 |
Inflammatory and non-inflammatory monocytes as novel prognostic biomarkers of survival in SOD1G93A mouse model of Amyotrophic Lateral Sclerosis
S Gasco, P Zaragoza, A García-Redondo, AC Calvo, R Osta, A Musaro |
PloS one | 2017 |
Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model
A Fellner, Y Barhum, A Angel, N Perets, I Steiner, D Offen, N Lev |
International journal of molecular sciences | 2017 |
Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications
J Liu, F Wang |
Frontiers in immunology | 2017 |
Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability: Fingolimod in ALS
JD Berry, S Paganoni, N Atassi, EA Macklin, N Goyal, M Rivner, E Simpson, S Appel, DL Grasso, NI Mejia, F Mateen, A Gill, F Vieira, V Tassinari, S Perrin |
Muscle & Nerve | 2017 |
Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina
P Hu, NH Hunt, F Arfuso, LC Shaw, MN Uddin, M Zhu, R Devasahayam, SJ Adamson, VL Benson, T Chan-Ling, MB Grant |
Investigative ophthalmology & visual science | 2017 |
Pharmacological inhibition of complement C5a-C5a 1 receptor signalling ameliorates disease pathology in the hSOD1 G93A mouse model of amyotrophic lateral sclerosis: C5a 1 receptor antagonism is protective in ALS mice
JD Lee, V Kumar, JN Fung, MJ Ruitenberg, PG Noakes, TM Woodruff |
British Journal of Pharmacology | 2017 |
The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis
G Chiarotto, G Nardo, M Trolese, M França, C Bendotti, AR de Oliveira |
International journal of molecular sciences | 2017 |
Lack of SOCS3 increases LPS-induced murine acute lung injury through modulation of Ly6C(+) macrophages
Z Jiang, Z Chen, L Li, W Zhou, L Zhu |
Respiratory Research | 2017 |
Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
W Zhao, DR Beers, KG Hooten, DH Sieglaff, A Zhang, S Kalyana-Sundaram, CM Traini, WS Halsey, AM Hughes, GM Sathe, GP Livi, GH Fan, SH Appel |
JAMA NEUROL | 2017 |
Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression
BJ Murdock, T Zhou, SR Kashlan, RJ Little, SA Goutman, EL Feldman |
JAMA NEUROL | 2017 |
Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry
E Martin, M El-Behi, B Fontaine, C Delarasse |
Journal of visualized experiments : JoVE | 2017 |
MicroRNA Metabolism and Dysregulation in Amyotrophic Lateral Sclerosis.
Rinchetti P, Rizzuti M, Faravelli I, Corti S |
Molecular Neurobiology | 2017 |
Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.
Cunha C, Santos C, Gomes C, Fernandes A, Correia AM, Sebastião AM, Vaz AR, Brites D |
Molecular Neurobiology | 2017 |
Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis
E Trias, S Ibarburu, R Barreto-Núñez, J Babdor, TT Maciel, M Guillo, L Gros, P Dubreuil, P Díaz-Amarilla, P Cassina, L Martínez-Palma, IC Moura, JS Beckman, O Hermine, L Barbeito |
Journal of Neuroinflammation | 2016 |
Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery
C Xing, EH Lo |
Progress in Neurobiology | 2016 |
Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors
JE Anttila, KW Whitaker, ES Wires, BK Harvey, M Airavaara |
Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2016 |
Inflammatory Disequilibrium in Stroke
D Petrovic-Djergovic, SN Goonewardena, DJ Pinsky |
Circulation research | 2016 |
Reduction of cytosolic phospholipase A2α upregulation delays the onset of symptoms in SOD1G93A mouse model of amyotrophic lateral sclerosis
Y Solomonov, N Hadad, R Levy |
Journal of Neuroinflammation | 2016 |
Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target
L Du, Y Zhang, Y Chen, J Zhu, Y Yang, HL Zhang |
Molecular Neurobiology | 2016 |
Dark microglia: A new phenotype predominantly associated with pathological states: A New Microglial Phenotype
K Bisht, KP Sharma, C Lecours, MG Sánchez, HE Hajj, G Milior, A Olmos-Alonso, D Gómez-Nicola, G Luheshi, L Vallières, I Branchi, L Maggi, C Limatola, O Butovsky, MÈ Tremblay |
Glia | 2016 |
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease
AD Thome, AS Harms, LA Volpicelli-Daley, DG Standaert |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2016 |
Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms
C Figueroa-Romero, J Hur, JS Lunn, X Paez-Colasante, DE Bender, R Yung, SA Sakowski, EL Feldman |
Molecular and Cellular Neuroscience | 2016 |
The retinal pigment epithelium as a gateway for monocyte trafficking into the eye
I Benhar, K Reemst, V Kalchenko, M Schwartz |
The EMBO Journal | 2016 |
Control of the Inflammatory Macrophage Transcriptional Signature by miR-155
KA Jablonski, AD Gaudet, SA Amici, PG Popovich, M Guerau-de-Arellano, G Zissel |
PloS one | 2016 |
Activation of microglia by retroviral infection correlate with transient clearance of prions from the brain but does not change incubation time
C Muth, K Schröck, C Madore, K Hartmann, Z Fanek, O Butovsky, M Glatzel, S Krasemann |
Brain Pathology | 2016 |
Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus
NH Varvel, JJ Neher, A Bosch, W Wang, RM Ransohoff, RJ Miller, R Dingledine |
Proceedings of the National Academy of Sciences | 2016 |
CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves
A Martínez-Muriana, R Mancuso, I Francos-Quijorna, A Olmos-Alonso, R Osta, VH Perry, X Navarro, D Gomez-Nicola, R López-Vales |
Scientific Reports | 2016 |
Non-neuronal Cells in ALS: Role of Glial, Immune cells and Blood-CNS Barriers: Non-Neuronal Cells in ALS
F Puentes, A Malaspina, JM van Noort, S Amor |
Brain Pathology | 2016 |
Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders
Y Takahashi, Z Yu, M Sakai, H Tomita |
Frontiers in cellular neuroscience | 2016 |
Aberration of miRNAs Expression in Leukocytes from Sporadic Amyotrophic Lateral Sclerosis
YP Chen, QQ Wei, XP Chen, CY Li, B Cao, RW Ou, S Hadano, HF Shang |
Frontiers in molecular neuroscience | 2016 |
Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism
F Patin, T Baranek, P Vourch, L Nadal-Desbarats, JF Goossens, S Marouillat, AF Dessein, A Descat, BM Hounoum, C Bruno, H Watier, M Si-Tahar, S Leman, JC Lecron, CR Andres, P Corcia, H Blasco |
Neurotherapeutics | 2016 |
Chemical dampening of Ly6Chi monocytes in the periphery produces anti-depressant effects in mice
X Zheng, S Ma, A Kang, M Wu, L Wang, Q Wang, G Wang, H Hao |
Scientific Reports | 2016 |
Increased ratio of circulating neutrophils to monocytes in amyotrophic lateral sclerosis
BJ Murdock, DE Bender, SR Kashlan, C Figueroa-Romero, C Backus, BC Callaghan, SA Goutman, EL Feldman |
Neurology: Neuroimmunology & Neuroinflammation | 2016 |
The brain parenchyma has a type I interferon response that can limit virus spread
E Drokhlyansky, DG Aytürk, TK Soh, R Chrenek, E OLoughlin, C Madore, O Butovsky, CL Cepko |
Proceedings of the National Academy of Sciences | 2016 |
Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms
S Freiesleben, M Hecker, UK Zettl, G Fuellen, L Taher |
Scientific Reports | 2016 |
M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b
C Parisi, G Napoli, P Pelegrin, C Volonté |
Mediators of Inflammation | 2016 |
Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis
LT Vu, R Bowser |
Neurotherapeutics | 2016 |
Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage
M Li, Z Li, H Ren, WN Jin, K Wood, Q Liu, KN Sheth, FD Shi |
Journal of Cerebral Blood Flow & Metabolism | 2016 |
Microglia across the lifespan: from origin to function in brain development, plasticity and cognition: Microglia across the lifespan
TL Tay, JC Savage, CW Hui, K Bisht, MÈ Tremblay |
The Journal of Physiology | 2016 |
Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture
ZA Miller, VE Sturm, GB Camsari, A Karydas, JS Yokoyama, LT Grinberg, AL Boxer, HJ Rosen, KP Rankin, ML Gorno-Tempini, G Coppola, DH Geschwind, R Rademakers, WW Seeley, NR Graff-Radford, BL Miller |
Neurology: Neuroimmunology & Neuroinflammation | 2016 |
Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis
L Pasetto, S Pozzi, M Castelnovo, M Basso, AG Estevez, S Fumagalli, MG Simoni, V Castellaneta, P Bigini, E Restelli, R Chiesa, F Trojsi, MR Monsurrò, L Callea, M Malešević, G Fischer, M Freschi, M Tortarolo, C Bendotti, V Bonetto |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2016 |
Impaired activation of ALS monocytes by exosomes
L Zondler, MS Feiler, A Freischmidt, WP Ruf, AC Ludolph, KM Danzer, JH Weishaupt |
Immunology and Cell Biology | 2016 |
MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease
JR Guedes, I Santana, C Cunha, D Duro, MR Almeida, AM Cardoso, MC de Lima, AL Cardoso |
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | 2015 |
Immunization with a Myelin-Derived Antigen Activates the Brain's Choroid Plexus for Recruitment of Immunoregulatory Cells to the CNS and Attenuates Disease Progression in a Mouse Model of ALS
G Kunis, K Baruch, O Miller, M Schwartz |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2015 |
Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells
J Herz, KR Johnson, DB McGavern |
Journal of Experimental Medicine | 2015 |
Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma
A Bosco, CO Romero, KT Breen, AA Chagovetz, MR Steele, BK Ambati, ML Vetter |
Disease models & mechanisms | 2015 |
Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice
L Gao, D Brenner, E Llorens-Bobadilla, G Saiz-Castro, T Frank, P Wieghofer, O Hill, M Thiemann, S Karray, M Prinz, JH Weishaupt, A Martin-Villalba |
Journal of Experimental Medicine | 2015 |
Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease
Heather E. Allen Reish, David G. Standaert |
Journal of Parkinson's disease | 2015 |
Novel Markers to Delineate Murine M1 and M2 Macrophages
KA Jablonski, SA Amici, LM Webb, JD Ruiz-Rosado, PG Popovich, S Partida-Sanchez, M Guerau-de-Arellano, MA Olszewski |
PloS one | 2015 |
Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions: ALS & PLS fibroblasts as cell models for sporadic disease
R Raman, SP Allen, EF Goodall, S Kramer, LL Ponger, PR Heath, M Milo, HC Hollinger, T Walsh, JR Highley, S Olpin, CJ McDermott, PJ Shaw, J Kirby |
Neuropathology and Applied Neurobiology | 2015 |
Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?
KA Nicholson, ME Cudkowicz, JD Berry |
Neurotherapeutics | 2015 |
Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis
KG Hooten, DR Beers, W Zhao, SH Appel |
Neurotherapeutics | 2015 |
P2Y12 expression and function in alternatively activated human microglia
CS Moore, AR Ase, A Kinsara, VT Rao, M Michell-Robinson, SY Leong, O Butovsky, SK Ludwin, P Seguela, A Bar-Or, JP Antel |
Neurology: Neuroimmunology & Neuroinflammation | 2015 |
Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency: Microglia Signature in Peroxisomal Mfp2 Deficiency
S Verheijden, L Beckers, A Casazza, O Butovsky, M Mazzone, M Baes |
Glia | 2015 |
Roles of microglia in brain development, tissue maintenance and repair
MA Michell-Robinson, H Touil, LM Healy, DR Owen, BA Durafourt, A Bar-Or, JP Antel, CS Moore |
Brain | 2015 |
Advances in toponomics drug discovery: Imaging cycler microscopy correctly predicts a therapy method of amyotrophic lateral sclerosis: ALS toponome
W Schubert |
Cytometry Part A | 2015 |
Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era
X Paez-Colasante, C Figueroa-Romero, SA Sakowski, SA Goutman, EL Feldman |
Nature Reviews Neurology | 2015 |
Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS
RG Miller, G Block, JS Katz, RJ Barohn, V Gopalakrishnan, M Cudkowicz, JR Zhang, MS McGrath, E Ludington, SH Appel, A Azhir |
Neurology: Neuroimmunology & Neuroinflammation | 2015 |
Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice
P Hu, JS Thinschmidt, S Caballero, S Adamson, L Cole, T Chan-Ling, MB Grant |
American journal of physiology. Endocrinology and metabolism | 2015 |
CD4 + T Cells and Neuroprotection: Relevance to Motoneuron Injury and Disease
KJ Jones, AE Lovett-Racke, CL Walker, VM Sanders |
Journal of Neuroimmune Pharmacology | 2015 |
Functional differences between microglia and monocytes after ischemic stroke
RM Ritzel, AR Patel, JM Grenier, J Crapser, R Verma, ER Jellison, LD McCullough |
Journal of Neuroinflammation | 2015 |
Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus
RA Rice, EE Spangenberg, H Yamate-Morgan, RJ Lee, RP Arora, MX Hernandez, AJ Tenner, BL West, KN Green |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2015 |
Editorial on the original article entitled "Genetic validation of a therapeutic target in a mouse model of ALS" published in the Science Translational Medicine on August 6, 2014
Vincenzo Silani |
Annals of translational medicine | 2015 |
New insights into the multidimensional concept of macrophage ontogeny, activation and function
F Ginhoux, JL Schultze, PJ Murray, J Ochando, SK Biswas |
Nature Immunology | 2015 |
Central nervous system myeloid cells as drug targets: current status and translational challenges
K Biber, T Möller, E Boddeke, M Prinz |
Nature Reviews Drug Discovery | 2015 |
microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases
I Basak, KS Patil, G Alves, JP Larsen, SG Møller |
Cellular and Molecular Life Sciences | 2015 |
Origin of Microglia: Current Concepts and Past Controversies
F Ginhoux, M Prinz |
Cold Spring Harbor perspectives in biology | 2015 |
NP001 regulation of macrophage activation markers in ALS: A phase I clinical and biomarker study
RG Miller, R Zhang, G Block, J Katz, R Barohn, E Kasarskis, D Forshew, V Gopalakrishnan, MS McGrath |
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration | 2014 |
Therapeutic inflammatory monocyte modulation using immune-modifying microparticles
DR Getts, RL Terry, MT Getts, C Deffrasnes, M Müller, C Vreden, TM Ashhurst, B Chami, D McCarthy, H Wu, J Ma, A Martin, LD Shae, P Witting, GS Kansas, J Kühn, W Hafezi, IL Campbell, D Reilly, J Say, L Brown, MY White, SJ Cordwell, SJ Chadban, EB Thorp, S Bao, SD Miller, NJ King |
Science Translational Medicine | 2014 |
Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
S Apolloni, S Amadio, C Parisi, A Matteucci, RL Potenza, M Armida, P Popoli, N DAmbrosi, C Volonté |
Disease models & mechanisms | 2014 |
Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients
V Grozdanov, C Bliederhaeuser, WP Ruf, V Roth, K Fundel-Clemens, L Zondler, D Brenner, A Martin-Villalba, B Hengerer, J Kassubek, AC Ludolph, JH Weishaupt, KM Danzer |
Acta Neuropathologica | 2014 |
Glial cells in amyotrophic lateral sclerosis
T Philips, JD Rothstein |
Experimental Neurology | 2014 |
The plasticity of inflammatory monocyte responses to the inflamed central nervous system
TM Ashhurst, C van Vreden, P Niewold, NJ King |
Cellular Immunology | 2014 |
Microglia centered pathogenesis in ALS: insights in cell interconnectivity
D Brites, AR Vaz |
Frontiers in cellular neuroscience | 2014 |
Accelerated Neurodegeneration and Neuroinflammation in Transgenic Mice Expressing P301L Tau Mutant and Tau-Tubulin Kinase 1
H Asai, S Ikezu, ME Woodbury, GM Yonemoto, L Cui, T Ikezu |
The American Journal of Pathology | 2014 |
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
M Prinz, J Priller |
Nature Reviews Neuroscience | 2014 |
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
AE Frakes, L Ferraiuolo, AM Haidet-Phillips, L Schmelzer, L Braun, CJ Miranda, KJ Ladner, AK Bevan, KD Foust, JP Godbout, PG Popovich, DC Guttridge, BK Kaspar |
Neuron | 2014 |
The role of miRNA in motor neuron disease
MJ Kye, IC Gonçalves |
Frontiers in cellular neuroscience | 2014 |
Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice: Role of miR-155 in ALS
O Butovsky, MP Jedrychowski, R Cialic, S Krasemann, G Murugaiyan, Z Fanek, DJ Greco, PM Wu, CE Doykan, O Kiner, RJ Lawson, MP Frosch, N Pochet, RE Fatimy, AM Krichevsky, SP Gygi, H Lassmann, J Berry, ME Cudkowicz, HL Weiner |
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M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?
MS Moehle, AB West |
Neuroscience | 2014 |
Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis
S Tada, T Okuno, Y Hitoshi, T Yasui, J Honorat, K Takata, T Koda, H Shimagami, C Chi-Jing, A Namba, T Sugimoto, S Sakoda, H Mochizuki, H Kikutani, Y Nakatsuji |
Journal of Neuroinflammation | 2014 |
Use of biomarkers in ALS drug development and clinical trials
N Bakkar, A Boehringer, R Bowser |
Brain Research | 2014 |
Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice
JI Ayers, S Fromholt, O Sinyavskaya, Z Siemienski, AM Rosario, A Li, KW Crosby, PE Cruz, NM DiNunno, C Janus, C Ceballos-Diaz, DR Borchelt, TE Golde, P Chakrabarty, Y Levites |
Molecular Therapy | 2014 |
MicroRNAs as Potential Circulating Biomarkers for Amyotrophic Lateral Sclerosis
F Cloutier, A Marrero, C O’Connell, PJ Morin |
Journal of Molecular Neuroscience | 2014 |
Ontogeny and Functions of Central Nervous System Macrophages
A Katsumoto, H Lu, AS Miranda, RM Ransohoff |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
Circulating miRNAs as Biomarkers for Neurodegenerative Disorders
M Grasso, P Piscopo, A Confaloni, M Denti |
Molecules (Basel, Switzerland) | 2014 |
Outcome measures in amyotrophic lateral sclerosis clinical trials.
Paganoni S, Cudkowicz M, Berry JD |
Clinical Investigation | 2014 |
Defective inflammatory monocyte development in IRF8-deficient mice abrogates migration to the West Nile virus-infected brain.
Terry RL, Deffrasnes C, Getts DR, Minten C, van Vreden C, Ashhurst TM, Getts MT, Xie RD, Campbell IL, King NJ |
Journal of Innate Immunity | 2014 |
Thinking Laterally About Neurodegenerative Proteinopathies
Todd Golde, David Borchelt, benoit giasson, Jada Lewis |
Journal of Clinical Investigation | 2013 |
Dramatic Antitumor Effects of the Dual MET/RON Small-Molecule Inhibitor LY2801653 in Non-Small Cell Lung Cancer
I Kawada, R Hasina, Q Arif, J Mueller, E Smithberger, AN Husain, EE Vokes, R Salgia |
Cancer research | 2013 |
The changing scene of amyotrophic lateral sclerosis
W Robberecht, T Philips |
Nature Reviews Neuroscience | 2013 |
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
ED Koval, C Shaner, P Zhang, X Maine, K Fischer, J Tay, BN Chau, GF Wu, TM Miller |
Human Molecular Genetics | 2013 |
Functional diversity of microglia - how heterogeneous are they to begin with?
UK Hanisch |
Frontiers in cellular neuroscience | 2013 |
Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair
A London, M Cohen, M Schwartz |
Frontiers in cellular neuroscience | 2013 |
Identification of a unique TGF-β-dependent molecular and functional signature in microglia
O Butovsky, MP Jedrychowski, CS Moore, R Cialic, AJ Lanser, G Gabriely, T Koeglsperger, B Dake, PM Wu, CE Doykan, Z Fanek, L Liu, Z Chen, JD Rothstein, RM Ransohoff, SP Gygi, JP Antel, HL Weiner |
Nature Neuroscience | 2013 |
The involvement of microRNAs in neurodegenerative diseases
S Maciotta, M Meregalli, Y Torrente |
Frontiers in cellular neuroscience | 2013 |
A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
IM Chiu, ET Morimoto, H Goodarzi, JT Liao, S O’Keeffe, HP Phatnani, M Muratet, MC Carroll, S Levy, S Tavazoie, RM Myers, T Maniatis |
Cell Reports | 2013 |
Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis
W Zhao, DR Beers, SH Appel |
Journal of Neuroimmune Pharmacology | 2013 |
Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis
F Rizzo, G Riboldi, S Salani, M Nizzardo, C Simone, S Corti, E Hedlund |
Experientia | 2013 |
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
CS Lobsiger, S Boillee, C Pozniak, AM Khan, M McAlonis-Downes, JW Lewcock, DW Cleveland |
Proceedings of the National Academy of Sciences | 2013 |
Microglial Phenotype and Adaptation
BJ Eggen, D Raj, UK Hanisch, HW Boddeke |
Journal of Neuroimmune Pharmacology | 2013 |
The multifaceted role of glial cells in amyotrophic lateral sclerosis
CF Valori, L Brambilla, F Martorana, D Rossi |
Cellular and Molecular Life Sciences | 2013 |
Minocycline selectively inhibits M1 polarization of microglia
K Kobayashi, S Imagama, T Ohgomori, K Hirano, K Uchimura, K Sakamoto, A Hirakawa, H Takeuchi, A Suzumura, N Ishiguro, K Kadomatsu |
Cell Death and Disease | 2013 |
MicroRNAs and Molecular Mechanisms of Neurodegeneration
I Bicchi, F Morena, S Montesano, M Polidoro, S Martino |
Genes & development | 2013 |
Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
C Parisi, I Arisi, N D'Ambrosi, AE Storti, R Brandi, M D'Onofrio, C Volonté |
Cell Death and Disease | 2013 |
MCP-1/CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS
M Kawaguchi-Niida, T Yamamoto, Y Kato, Y Inose, N Shibata |
Acta Neuropathologica Communications | 2013 |
Neuronal dark matter: the emerging role of microRNAs in neurodegeneration
EF Goodall, PR Heath, O Bandmann, J Kirby, PJ Shaw |
Frontiers in cellular neuroscience | 2013 |
Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia
SJ Kim, J Li |
Cell Death and Disease | 2013 |
Involvement of microRNA in microglia-mediated immune response
J Guedes, AL Cardoso, MC de Lima |
Clinical & developmental immunology | 2013 |
Inflammatory monocytes and the pathogenesis of viral encephalitis
RL Terry, DR Getts, C Deffrasnes, C Vreden, IL Campbell, NJ King |
Journal of Neuroinflammation | 2012 |
Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis
C Figueroa-Romero, J Hur, DE Bender, CE Delaney, MD Cataldo, AL Smith, R Yung, DM Ruden, BC Callaghan, EL Feldman |
PloS one | 2012 |
Motor neuron disease: inflammatory monocytes--a novel therapeutic target for ALS?
Malpass K |
Nature reviews. Neurology | 2012 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |