Popeye proteins: muscle for the aging sinus node
Bastiaan J. Boukens, Vincent M. Christoffels
Bastiaan J. Boukens, Vincent M. Christoffels
Published March 1, 2012; First published February 22, 2012
Citation Information: J Clin Invest. 2012;122(3):810-813. https://doi.org/10.1172/JCI62588.
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Commentary

Popeye proteins: muscle for the aging sinus node

Abstract

The electrical impulses that dictate the rhythm of the heartbeat in normal situations and during exercise or stress are initiated by a small number of sinus node pacemaker cells. Senescence and dysfunction of the sinus node affects many people later in life, causing physiologically inappropriate heart rates, but the underlying mechanisms are not well understood. In this issue of the JCI, Froese and colleagues show that deficiency in either Popeye domain containing 1 (Popdc1) or Popdc2 leads to sinus node dysfunction under stressed conditions in aged mice. The mechanism reported to underlie the effects of Popdc1/2 deficiency in mice may cause the stress-induced sinus node dysfunction found in many aged individuals and may point to new strategies for therapeutic intervention.

Authors

Bastiaan J. Boukens, Vincent M. Christoffels

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Figure 1

Possible explanations for stress-induced sinus dysfunction in mice mutant for either Popdc1 or Popdc2.

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Possible explanations for stress-induced sinus dysfunction in mice mutan...
(A) Wild-type sinus node and atrium. The origin of electrical impulse activation shifts upon stimulation of the β-adrenergic receptor to the inferior part of the sinus node. An electrocardiogram with normal activation of the atria is also shown. Note that the PP interval is regular. (B) Sinus node and atrium from a mouse mutant for either Popdc1 or Popdc2. The origin of electrical impulse activation cannot shift to the inferior part of the sinus node, because this part is absent. Furthermore, the sinus node has reduced in size, which may cause exit block or failure of impulse formation. An electrocardiogram during sinus node exit block or failure of impulse formation is also shown. Note that failure of atrial activation leads to an increase in PP interval (a so-called sinus pause).