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Citations to this article

The flip-flop HuR: part of the problem or the solution in fighting cancer?
Jacqueline C. Shultz, Charles E. Chalfant
Jacqueline C. Shultz, Charles E. Chalfant
Published December 27, 2011
Citation Information: J Clin Invest. 2012;122(1):16-19. https://doi.org/10.1172/JCI61677.
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Commentary Article has an altmetric score of 3

The flip-flop HuR: part of the problem or the solution in fighting cancer?

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Abstract

Chronic inflammation has long been appreciated to play a critical role in tumor development and maintenance. Among the mechanisms involved in coordinating the initiation and resolution of inflammation are those responsible for modifying mRNA stability and/or translation. Several studies have linked the RNA-binding protein HuR, which increases mRNA stability, with malignant transformation. However, in this issue of the JCI, Yiakouvaki et al. compellingly demonstrate in mice that increased HuR activity in myeloid cells has a protective role in the onset of pathologic intestinal inflammation (i.e., colitis) and colitis-associated cancer (CAC). These observations highlight the need to understand the roles of HuR in distinct cell populations in vivo and suggest that enhancing HuR activity may be of clinical benefit in protecting against pathologic inflammation and cancer.

Authors

Jacqueline C. Shultz, Charles E. Chalfant

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Total citations by year

Year: 2015 2013 Total
Citations: 1 2 3
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2015 (1)

Title and authors Publication Year
Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways
SH Suleiman, ME Koko, WH Nasir, O Elfateh, UK Elgizouli, MO Abdallah, KO Alfarouk, A Hussain, S Faisal, FM Ibrahim, M Romano, A Sultan, L Banks, M Newport, F Baralle, AM Elhassan, HS Mohamed, ME Ibrahim
Frontiers in Genetics 2015

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