JCI - Citations to Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity

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Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity

Kirby D. Johnson, … , Steven M. Holland, Emery H. Bresnick

Kirby D. Johnson, … , Steven M. Holland, Emery H. Bresnick

Published September 10, 2012
Citation Information: J Clin Invest. 2012;122(10):3692-3704. https://doi.org/10.1172/JCI61623.

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Citations to this article (124)

Title and authors	Publication	Year
Modeling GATA2 deficiency in mice: the R396Q mutation disrupts normal hematopoiesis Hall T, Mehmood R, Sá da Bandeira D, Cotton A, Klein J, Pruett-Miller SM, Izraeli S, Clements WK, Crispino JD	Leukemia	2025
Insights into Pediatric GATA2-Related MDS: Unveiling Challenges in Clinical Practice Marcu AD, Bica AM, Jercan CG, Radu LE, Serbanica AN, Jardan D, Colita A, Dima SO, Tomuleasa C, Tanase AD, Colita A	Biomedicines	2025
Signaling mechanisms and cis-regulatory control of Samd14 in erythroid regeneration Hewitt KJ, Roy P, Schaefer MA	Current opinion in hematology	2025
Pathogenic GATA2 genetic variants utilize an obligate enhancer mechanism to distort a multilineage differentiation program. Katsumura KR, Liu P, Kim JA, Mehta C, Bresnick EH	Proceedings of the National Academy of Sciences	2024
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells Katerndahl CD, Rogers OR, Day RB, Xu Z, Helton NM, Ramakrishnan SM, Miller CA, Ley TJ	Proceedings of the National Academy of Sciences	2024
Functional categorization of gene regulatory variants that cause Mendelian conditions Cheng YH, Bohaczuk SC, Stergachis AB	Human Genetics	2024
Oncogenic Enhancers in Leukemia Mulet-Lazaro R, Delwel R	Blood Cancer Discovery	2024
Pathogenic Human Variant that Dislocates GATA2 Zinc Fingers Establishes Hematopoiesis-Disrupting Gene Expression and Signaling Networks Mabel Jung, Siqi Shen, Giovanni Botten, Koichi Katsumura, Alexandra Soukup, Peng Liu, Robert Beagrie, Joel Mackay, Kirby Johnson, Lucy Godley, Jian Xu, Sunduz Keles, Emery Bresnick	Journal of Clinical Investigation	2023
Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells Fortin J, Chiang MF, Meydan C, Foox J, Ramachandran P, Leca J, Lemonnier F, Li WY, Gams MS, Sakamoto T, Chu M, Tobin C, Laugesen E, Robinson TM, You-Ten A, Butler DJ, Berger T, Minden MD, Levine RL, Guidos CJ, Melnick AM, Mason CE, Mak TW	Proceedings of the National Academy of Sciences	2023
The Clinical Spectrum, Diagnosis, and Management of GATA2 Deficiency Santiago M, Liquori A, Such E, Zúñiga Á, Cervera J	Cancers	2023
Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells Tran VL, Liu P, Katsumura KR, Kim E, Schoff BM, Johnson KD, Bresnick EH	iScience	2023
Long noncoding RNA GATA2-AS1 augments endothelial hypoxia inducible factor 1-α induction and regulates hypoxic signaling Man HS, Subramaniam N, Downs T, Sukumar AN, Saha AD, Nair R, Chen L, Teitelbaum D, Turgeon PJ, Ku KH, Tran E, de Perrot M, Marsden PA	The Journal of biological chemistry	2023
Interferon Regulatory Factor-8-Dependent Innate Immune Alarm Senses GATA2 Deficiency to Alter Hematopoietic Differentiation and Function Johnson KD, Jung MM, Tran VL, Bresnick EH	Current Opinion in Hematology	2023
GATA2 Deficiency: Predisposition to Myeloid Malignancy and Hematopoietic Cell Transplantation. Rajput RV, Arnold DE	Current Hematologic Malignancy Reports	2023
Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis. Tenney AP, Di Gioia SA, Webb BD, Chan WM, de Boer E, Garnai SJ, Barry BJ, Ray T, Kosicki M, Robson CD, Zhang Z, Collins TE, Gelber A, Pratt BM, Fujiwara Y, Varshney A, Lek M, Warburton PE, Van Ryzin C, Lehky TJ, Zalewski C, King KA, Brewer CC, Thurm A, Snow J, Facio FM, Narisu N, Bonnycastle LL, Swift A, Chines PS, Bell JL, Mohan S, Whitman MC, Staffieri SE, Elder JE, Demer JL, Torres A, Rachid E, Al-Haddad C, Boustany RM, Mackey DA, Brady AF, Fenollar-Cortés M, Fradin M, Kleefstra T, Padberg GW, Raskin S, Sato MT, Orkin SH, Parker SCJ, Hadlock TA, Vissers LELM, van Bokhoven H, Jabs EW, Collins FS, Pennacchio LA, Manoli I, Engle EC	Nature Genetics	2023
Needle in a haystack or elephant in the room? Identifying germline predisposition syndromes in the setting of a new myeloid malignancy diagnosis. Reinig EF, Rubinstein JD, Patil AT, Schussman AL, Horner VL, Kanagal-Shamanna R, Churpek JE, Matson DR	Leukemia	2023
Breaking enhancers to gain insights into developmental defects Armendariz DA, Sundarrajan A, Hon GC	eLife	2023
A novel GATA2 distal enhancer mutation results in MonoMAC syndrome in 2 second cousins West RR, Bauer TR Jr, Tuschong LM, Embree LJ, Calvo KR, Tillo D, Davis J, Holland SM, Hickstein DD	Blood Advances	2023
Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function Zhou Y, Dogiparthi VR, Ray S, Schaefer MA, Harris HL, Rowley MJ, Hewitt KJ	Blood Advances	2023
From Genotype to Phenotype: How Enhancers Control Gene Expression and Cell Identity in Hematopoiesis Mulet-Lazaro R, Delwel R	HemaSphere	2023
Gata2 noncoding genetic variation as a determinant of hematopoietic stem/progenitor cell mobilization efficiency Soukup AA, Bresnick EH	Blood Advances	2023
Linking GATA2 to myeloid dysplasia and complex cytogenetics in adult myelodysplastic neoplasm and acute myeloid leukemia Robbins DJ, Pavletich TS, Patil AT, Pahopos D, Lasarev M, Polaki US, Gahvari ZJ, Bresnick EH, Matson DR	Blood Advances	2023
Transcription factors regulating vasculogenesis and angiogenesis Payne S, Neal A, De Val S	Developmental Dynamics	2023
Developmental disorders caused by haploinsufficiency of transcriptional regulators: a perspective based on cell fate determination R Zug	Biology Open	2022
Gata2 +9.5 enhancer regulates adult hematopoietic stem cell self-renewal and T-cell development X You, Y Zhou, Y Chang, G Kong, E Ranheim, K Johnson, A Soukup, E Bresnick, J Zhang	Blood Advances	2022
GATA2 deficiency elevates interferon regulatory factor-8 to subvert a progenitor cell differentiation program K Johnson, A Soukup, E Bresnick	Blood Advances	2022
GATA 2 Deficiency: Focus on Immune System Impairment Fabozzi F, Mastronuzzi A, Ceglie G, Masetti R, Leardini D	Frontiers in immunology	2022
Erythroid Cell Research: 3D Chromatin, Transcription Factors and Beyond Andrieu-Soler C, Soler E	International journal of molecular sciences	2022
Endothelial Cell GATA2 Modulates the Cardiomyocyte Stress Response through the Regulation of Two Long Non-Coding RNAs Froese N, Szaroszyk M, Korf-Klingebiel M, Koch K, Schmitto JD, Geffers R, Hilfiker-Kleiner D, Riehle C, Wollert KC, Bauersachs J, Heineke J	Biology	2022
GATA2 deficiency and MDS/AML: Experimental strategies for disease modelling and future therapeutic prospects. Kotmayer L, Romero-Moya D, Marin-Bejar O, Kozyra E, Català A, Bigas A, Wlodarski MW, Bödör C, Giorgetti A	British Journal of Haematology	2022
The spectrum of GATA2 deficiency syndrome Calvo KR, Hickstein DD	Blood	2022
Tumor suppressor function of Gata2 in acute promyelocytic leukemia CD Katerndahl, OR Rogers, RB Day, MA Cai, TP Rooney, NM Helton, M Hoock, SM Ramakrishnan, SN Srivatsan, LD Wartman, CA Miller, TJ Ley	Blood	2021
Inherited GATA2 Deficiency Is Dominant by Haploinsufficiency and Displays Incomplete Clinical Penetrance C Oleaga-Quintas, EB de Oliveira-Júnior, J Rosain, F Rapaport, C Deswarte, A Guérin, SM Sajjath, YJ Zhou, S Marot, C Lozano, L Branco, N Fernández-Hidalgo, DB Lew, AS Brunel, C Thomas, E Launay, AA Arias, A Cuffel, VC Monjo, AL Neehus, L Marques, M Roynard, M Moncada-Vélez, B Gerçeker, R Colobran, MG Vigué, G Lopez-Herrera, L Berron-Ruiz, NH Méndez, PO Romanillos, TL Voyer, A Puel, C Bellanné-Chantelot, KA Ramirez, L Lorenzo-Diaz, NR Alejo, RP de Diego, A Condino-Neto, F Mellouli, C Rodriguez-Gallego, T Witte, JF Restrepo, M Jobim, S Boisson-Dupuis, E Jeziorski, C Fieschi, G Vogt, J Donadieu, M Pasquet, J Vasconcelos, FO Ardeniz, M Martínez-Gallo, RA Campos, LF Jobim, R Martínez-Barricarte, K Liu, A Cobat, L Abel, JL Casanova, J Bustamante	Journal of Clinical Immunology	2021
Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance J Takai, T Shimada, T Nakamura, JD Engel, T Moriguchi	iScience	2021
GATA2 deficiency syndrome: A decade of discovery CC Homan, P Venugopal, P Arts, NH Shahrin, S Feurstein, L Rawlings, DM Lawrence, J Andrews, SL KingSmith, NL Harvey, AL Brown, HS Scott, CN Hahn	Human Mutation	2021
Conditionally pathogenic genetic variants of a hematopoietic disease–suppressing enhancer AA Soukup, DR Matson, P Liu, KD Johnson, EH Bresnick	Science Advances	2021
miR‐181c regulates MCL1 and cell survival in GATA2 deficient cells W Wang, R Chen, S Droll, E Barber, L Saleh, M CorriganCummins, M Trick, V Anastas, NV Hawk, Z Zhao, DC Vinh, A Hsu, DD Hickstein, SM Holland, KR Calvo	Journal of leukocyte biology	2021
Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model YK Fu, Y Tan, B Wu, YT Dai, XG Xu, MM Pan, ZW Chen, N Qiao, J Wu, L Jiang, J Lu, B Chen, A Rein, S Izraeli, XJ Sun, JY Huang, QH Huang, Z Chen, SJ Chen	Cell Death and Disease	2021
Gynecologic manifestations in Emberger syndrome H Yüksel, E Zafer	Journal of Turkish Society of Obstetric and Gynecology	2021
A Nationwide Study of GATA2 Deficiency in Norway—the Majority of Patients Have Undergone Allo-HSCT SF Jørgensen, J Buechner, AE Myhre, E Galteland, S Spetalen, MA Kulseth, HS Sorte, ØL Holla, E Lundman, C Alme, I Heier, T Flægstad, Y Fløisand, A Benneche, B Fevang, P Aukrust, A Stray-Pedersen, T Gedde-Dahl, I Nordøy	Journal of Clinical Immunology	2021
Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during aging A Abdelfattah, A Hughes-Davies, L Clayfield, J Menendez-Gonzalez, A Almotiri, B Alotaibi, A Tonks, N Rodrigues	Blood Advances	2021
Human GATA2 mutations and hematologic disease: how many paths to pathogenesis? EH Bresnick, MM Jung, KR Katsumura	Blood Advances	2020
Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages C Yin, AM Vrieze, M Rosoga, J Akingbasote, EN Pawlak, RA Jacob, J Hu, N Sharma, JD Dikeakos, L Barra, AD Nagpal, B Heit	Frontiers in immunology	2020
Sterile α-motif domain requirement for cellular signaling and survival S Ray, L Chee, DR Matson, NY Palermo, EH Bresnick, KJ Hewitt	The Journal of biological chemistry	2020
A splicing factor switch controls hematopoietic lineage specification of pluripotent stem cells Y Li, D Wang, H Wang, X Huang, Y Wen, BR Wang, C Xu, J Gao, J Liu, J Tong, M Wang, P Su, S Ren, F Ma, HD Li, EH Bresnick, J Zhou, L Shi	EMBO reports	2020
GATA2 Related Conditions and Predisposition to Pediatric Myelodysplastic Syndromes A Bruzzese, D Leardini, R Masetti, L Strocchio, K Girardi, M Algeri, GD Baldo, F Locatelli, A Mastronuzzi	Cancers	2020
GATA2 +9.5 enhancer: from principles of hematopoiesis to genetic diagnosis in precision medicine AA Soukup, EH Bresnick	Current Opinion in Hematology	2020
Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production N Hirahara, HM Nakamura, S Sasaki, A Matsushita, K Ohba, G Kuroda, Y Sakai, S Shinkai, H Haeno, T Nishio, S Yoshida, Y Oki, T Suda, H Ariga	PloS one	2020
Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories KD Johnson, DJ Conn, E Shishkova, KR Katsumura, P Liu, S Shen, EA Ranheim, SG Kraus, W Wang, KR Calvo, AP Hsu, SM Holland, JJ Coon, S Keles, EH Bresnick	Journal of Experimental Medicine	2020
Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells Y Zhou, B Mao, Y Chen, Y Xue, B Chen, Y Zhang, F Ma		2020
GATA2 and Progesterone Receptor Interaction in Endometrial Stromal Cells Undergoing Decidualization A Kohlmeier, CA Sison, BD Yilmaz, JS V, MT Dyson, SE Bulun	Endocrinology	2020
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants A Rio-Machin, T Vulliamy, N Hug, A Walne, K Tawana, S Cardoso, A Ellison, N Pontikos, J Wang, H Tummala, AF Seraihi, J Alnajar, F Bewicke-Copley, H Armes, M Barnett, A Bloor, C Bödör, D Bowen, P Fenaux, A Green, A Hallahan, H Hjorth-Hansen, U Hossain, S Killick, S Lawson, M Layton, AM Male, J Marsh, P Mehta, R Mous, JF Nomdedéu, C Owen, J Pavlu, EM Payne, RE Protheroe, C Preudhomme, N Pujol-Moix, A Renneville, N Russell, A Saggar, G Sciuccati, D Taussig, CL Toze, A Uyttebroeck, P Vandenberghe, B Schlegelberger, T Ripperger, D Steinemann, J Wu, J Mason, P Page, S Akiki, K Reay, JD Cavenagh, V Plagnol, JF Caceres, J Fitzgibbon, I Dokal	Nature Communications	2020
Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis T Dobrzycki, CB Mahony, M Krecsmarik, C Koyunlar, R Rispoli, J Peulen-Zink, K Gussinklo, B Fedlaoui, E de Pater, R Patient, R Monteiro		2020
Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages Y Lu, G Basatemur, IC Scott, D Chiarugi, M Clement, J Harrison, R Jugdaohsingh, X Yu, SA Newland, HE Jolin, X Li, X Chen, M Szymanska, G Haraldsen, G Palmer, PG Fallon, ES Cohen, AN McKenzie, Z Mallat	Immunity	2020
Comparison of Outcomes of Myeloablative Allogeneic Stem Cell Transplantation for Pediatric Patients with Bone Marrow Failure, Myelodysplastic Syndrome and Acute Myeloid Leukemia with and without Germline GATA2 Mutations I Hofmann, S Avagyan, A Stetson, D Guo, H Al-Sayegh, WB London, L Lehmann	Biology of Blood and Marrow Transplantation	2020
Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA) AL Brown, CN Hahn, HS Scott	Blood	2020
Germline GATA2 variant disrupting endothelial eNOS cell function and angiogenesis can be restored by c-Jun/AP-1 upregulation G Purgatorio, E Piselli, G Guglielmini, E Falcinelli, L Bury, VD Battista, F Pellanera, F Milano, C Matteucci, C Mecucci, P Gresele	Haematologica	2020
Transcription Factor Mutations as a Cause of Familial Myeloid Neoplasms Jane Churpek, Emery Bresnick	Journal of Clinical Investigation	2019
Single-Nucleotide Human Disease Mutation Inactivates a Blood-Regenerative GATA2 Enhancer Alexandra A. Soukup, Ye Zheng, Charu Mehta, Jun Wu, Peng Liu, Miao Cao, Inga Hofmann, Yun Zhou, Jing Zhang, Kirby D. Johnson, Kyunghee Choi, Sunduz Keles, Emery H. Bresnick	Journal of Clinical Investigation	2019
cis Elements that Mediate RNA Polymerase II Pausing Regulate Human Gene Expression JA Watts, J Burdick, J Daigneault, Z Zhu, C Grunseich, A Bruzel, VG Cheung	The American Journal of Human Genetics	2019
Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis T Ling, Y Birger, MJ Stankiewicz, N Ben-Haim, T Kalisky, A Rein, E Kugler, W Chen, C Fu, K Zhang, H Patel, JW Sikora, YA Goo, N Kelleher, L Zou, S Izraeli, JD Crispino	Blood	2019
Induction of developmental hematopoiesis mediated by transcription factors and the hematopoietic microenvironment MG Daniel, K Rapp, C Schaniel, KA Moore	Annals of the New York Academy of Sciences	2019
Valves Are a Conserved Feature of the Zebrafish Lymphatic System M Shin, T Nozaki, F Idrizi, S Isogai, K Ogasawara, K Ishida, S Yuge, B Roscoe, SA Wolfe, S Fukuhara, N Mochizuki, T Deguchi, ND Lawson	Developmental Cell	2019
Blood disease–causing and –suppressing transcriptional enhancers: general principles and GATA2 mechanisms EH Bresnick, KD Johnson	Blood Advances	2019
Establishment and maintenance of blood–lymph separation HP Janardhan, CM Trivedi	Cellular and Molecular Life Sciences	2019
GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm J Castaño, S Aranda, C Bueno, FJ Calero-Nieto, E Mejia-Ramirez, JL Mosquera, E Blanco, X Wang, C Prieto, L Zabaleta, E Mereu, M Rovira, S Jiménez-Delgado, DR Matson, H Heyn, EH Bresnick, B Göttgens, LD Croce, P Menendez, A Raya, A Giorgetti	Stem Cell Reports	2019
Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond EH Bresnick, KJ Hewitt, C Mehta, S Keles, RF Paulson, KD Johnson	Development (Cambridge, England)	2018
Bacille Calmette–Guerin Complications in Newly Described Primary Immunodeficiency Diseases: 2010–2017 C de Jesus Nunes-Santos, SD Rosenzweig	Frontiers in immunology	2018
Germline GATA2 Mutation and Bone Marrow Failure LJ McReynolds, KR Calvo, SM Holland	Hematology/Oncology Clinics of North America	2018
Ultraconserved Enhancers Are Required for Normal Development DE Dickel, AR Ypsilanti, R Pla, Y Zhu, I Barozzi, BJ Mannion, YS Khin, Y Fukuda-Yuzawa, I Plajzer-Frick, CS Pickle, EA Lee, AN Harrington, QT Pham, TH Garvin, M Kato, M Osterwalder, JA Akiyama, V Afzal, JL Rubenstein, LA Pennacchio, A Visel	Cell	2018
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency N Hernandez, I Melki, H Jing, T Habib, SS Huang, J Danielson, T Kula, S Drutman, S Belkaya, V Rattina, L Lorenzo-Diaz, A Boulai, Y Rose, N Kitabayashi, MP Rodero, C Dumaine, S Blanche, MN Lebras, MC Leung, LS Mathew, B Boisson, SY Zhang, S Boisson-Dupuis, S Giliani, D Chaussabel, LD Notarangelo, SJ Elledge, MJ Ciancanelli, L Abel, Q Zhang, N Marr, YJ Crow, HC Su, JL Casanova	Journal of Experimental Medicine	2018
Human leukemia mutations corrupt but do not abrogate GATA-2 function KR Katsumura, C Mehta, KJ Hewitt, AA Soukup, IF de Andrade, EA Ranheim, KD Johnson, EH Bresnick	Proceedings of the National Academy of Sciences	2018
Hdac3 regulates lymphovenous and lymphatic valve formation Harish Janardhan, Zachary Milstone, Masahiro Shin, Nathan Lawson, John Keaney, Chinmay Trivedi	Journal of Clinical Investigation	2017
Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program C Mehta, KD Johnson, X Gao, IM Ong, KR Katsumura, SC McIver, EA Ranheim, EH Bresnick	Cell Reports	2017
GATA factor mutations in hematologic disease JD Crispino, MS Horwitz	Blood	2017
Acquired Senescent T-Cell Phenotype Correlates with Clinical Severity in GATA Binding Protein 2-Deficient Patients R Ruiz-García, C Rodríguez-Vigil, FM Marco, F Gallego-Bustos, MJ Castro-Panete, L Diez-Alonso, C Muñoz-Ruiz, J Ruiz-Contreras, E Paz-Artal, LI González-Granado, LM Allende	Frontiers in immunology	2017
GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia KJ Hewitt, KR Katsumura, DR Matson, P Devadas, N Tanimura, AS Hebert, JJ Coon, JS Kim, CN Dewey, S Keles, S Hao, RF Paulson, EH Bresnick	Developmental Cell	2017
The GATA factor revolution in hematology KR Katsumura, EH Bresnick	Blood	2017
Heterogeneity of GATA2-related myeloid neoplasms S Hirabayashi, MW Wlodarski, E Kozyra, CM Niemeyer	International Journal of Hematology	2017
Integrating microRNA and messenger RNA expression profiles in a rat model of deep vein thrombosis QQ Jin, JH Sun, QX Du, XJ Lu, XY Zhu, HL Fan, C Hï½lscher, YY Wang	International journal of molecular medicine	2017
Hormone dependent uterine epithelial-stromal communication for pregnancy support X Wang, SP Wu, FJ DeMayo	Placenta	2017
Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer SH Song, MS Jeon, JW Nam, JK Kang, YJ Lee, JY Kang, HP Kim, SW Han, GH Kang, TY Kim	Oncogene	2017
A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function CA Rubel, SP Wu, L Lin, T Wang, RB Lanz, X Li, R Kommagani, HL Franco, SA Camper, Q Tong, JW Jeong, JP Lydon, FJ DeMayo	Cell Reports	2016
Current Topics in Developmental Biology KJ Hewitt, KD Johnson, X Gao, S Keles, EH Bresnick	Current topics in developmental biology	2016
Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors P Kaimakis, E Pater, C Eich, PS Kartalaei, ML Kauts, CS Vink, R der Linden, M Jaegle, T Yokomizo, D Meijer, E Dzierzak	Blood	2016
GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis X Gao, T Wu, KD Johnson, JL Lahvic, EA Ranheim, LI Zon, EH Bresnick	Stem Cell Reports	2016
GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells KR Katsumura, IM Ong, AW DeVilbiss, R Sanalkumar, EH Bresnick	Cell Reports	2016
Gata2 Is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice X Li, HD Huynh, H Zuo, M Salminen, Y Wan	Endocrinology	2016
A MAD-Bayes Algorithm for State-Space Inference and Clustering with Application to Querying Large Collections of ChIP-Seq Data Sets C Zuo, K Chen, S Keleş	Journal of Computational Biology	2016
A hierarchical framework for state-space matrix inference and clustering C Zuo, K Chen, KJ Hewitt, EH Bresnick, S Keleş	The Annals of Applied Statistics	2016
Lymphatic vessel development: fluid flow and valve-forming cells Tsutomu Kume	Journal of Clinical Investigation	2015
GATA2 is required for lymphatic vessel valve development and maintenance Jan Kazenwadel, Kelly Betterman, Chan-Eng Chong, Philippa Stokes, Young Lee, Genevieve Secker, Yan Agalarov, Cansaran Saygili Demir, David Lawrence, Drew Sutton, Sebastien Tabruyn, Naoyuki Miura, Marjo Salminen, Tatiana Petrova, Jacqueline M. Matthews, Christopher Hahn, Hamish Scott, Natasha Harvey	Journal of Clinical Investigation	2015
GATA2 deficiency: AP Hsu, LJ McReynolds, SM Holland	Current Opinion in Allergy and Clinical Immunology	2015
Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation N Tanimura, E Miller, K Igarashi, D Yang, JN Burstyn, CN Dewey, EH Bresnick	EMBO reports	2015
Haematopoietic and immune defects associated with GATA2 mutation M Collin, R Dickinson, V Bigley	British Journal of Haematology	2015
Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo E Butko, M Distel, C Pouget, B Weijts, I Kobayashi, K Ng, C Mosimann, FE Poulain, A McPherson, CW Ni, DL Stachura, ND Cid, R Espin-Palazon, ND Lawson, R Dorsky, WK Clements, D Traver	Development (Cambridge, England)	2015
Epigenetic Determinants of Erythropoiesis: Role of the Histone Methyltransferase SetD8 in Promoting Erythroid Cell Maturation and Survival AW DeVilbiss, R Sanalkumar, BD Hall, KR Katsumura, IF de Andrade, EH Bresnick	Molecular and cellular biology	2015
Cis-regulatory mechanisms governing stem and progenitor cell transitions KD Johnson, G Kong, X Gao, YI Chang, KJ Hewitt, R Sanalkumar, R Prathibha, EA Ranheim, CN Dewey, J Zhang, EH Bresnick	Science Advances	2015
Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes W Li, Z Jiang, T Li, X Wei, Y Zheng, D Wu, L Yang, S Chen, B Xu, M Zhong, J Jiang, Y Hu, H Su, M Zhang, X Huang, S Geng, J Weng, X Du, P Liu, Y Li, H Liu, Y Yao, P Li	Molecular Cancer	2015
Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome KJ Hewitt, DH Kim, P Devadas, R Prathibha, C Zuo, R Sanalkumar, KD Johnson, YA Kang, JS Kim, CN Dewey, S Keles, EH Bresnick	Molecular Cell	2015
Histone Methyltransferase Setd8 Represses Gata2 Expression and Regulates Erythroid Maturation J Malik, M Getman, LA Steiner	Molecular and cellular biology	2015
Malat1 as an evolutionarily conserved lncRNA, plays a positive role in regulating proliferation and maintaining undifferentiated status of early-stage hematopoietic cells XY Ma, JH Wang, JL Wang, CX Ma, XC Wang, FS Liu	BMC Genomics	2015
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis MC Canver, EC Smith, F Sher, L Pinello, NE Sanjana, O Shalem, DD Chen, PG Schupp, DS Vinjamur, SP Garcia, S Luc, R Kurita, Y Nakamura, Y Fujiwara, T Maeda, GC Yuan, F Zhang, SH Orkin, DE Bauer	Nature	2015
High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells Y Saito, T Fujiwara, K Ohashi, Y Okitsu, N Fukuhara, Y Onishi, K Ishizawa, H Harigae, T Akagi	PloS one	2015
New developments in clinical aspects of lymphatic disease Peter Mortimer, Stanley G. Rockson	Journal of Clinical Investigation	2014
A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21;q26) by Activating EVI1 Expression H Yamazaki, M Suzuki, A Otsuki, R Shimizu, EH Bresnick, JD Engel, M Yamamoto	Cancer Cell	2014
A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation T Moriguchi, M Yamamoto	International Journal of Hematology	2014
Epigenetic and genetic mechanisms in red cell biology: KJ Hewitt, R Sanalkumar, KD Johnson, S Keles, EH Bresnick	Current Opinion in Hematology	2014
Mechanism governing a stem cell-generating cis-regulatory element R Sanalkumar, KD Johnson, X Gao, ME Boyer, YI Chang, KJ Hewitt, J Zhang, EH Bresnick	Proceedings of the National Academy of Sciences	2014
Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2 KR Katsumura, C Yang, ME Boyer, L Li, EH Bresnick	EMBO reports	2014
Hematopoietic transcriptional mechanisms: From locus-specific to genome-wide vantage points AW DeVilbiss, R Sanalkumar, KD Johnson, S Keles, EH Bresnick	Experimental Hematology	2014
GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia KA Ganapathi, DM Townsley, AP Hsu, DC Arthur, CS Zerbe, J Cuellar-Rodriguez, DD Hickstein, SD Rosenzweig, RC Braylan, NS Young, SM Holland, KR Calvo	Blood	2014
Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation RR West, AP Hsu, SM Holland, J Cuellar-Rodriguez, DD Hickstein	Haematologica	2013
GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2 S Coma, M Allard-Ratick, T Akino, LA Meeteren, A Mammoto, M Klagsbrun	Angiogenesis	2013
The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases JD Milner, SM Holland	Nature Reviews Immunology	2013
Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset EM Mace, AP Hsu, L Monaco-Shawver, G Makedonas, JB Rosen, L Dropulic, JI Cohen, EP Frenkel, JC Bagwell, JL Sullivan, CA Biron, C Spalding, CS Zerbe, G Uzel, SM Holland, JS Orange	Blood	2013
GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome AP Hsu, KD Johnson, EL Falcone, R Sanalkumar, L Sanchez, DD Hickstein, J Cuellar-Rodriguez, JE Lemieux, CS Zerbe, EH Bresnick, SM Holland	Blood	2013
Gata2 is required for HSC generation and survival E Pater, P Kaimakis, CS Vink, T Yokomizo, T Yamada-Inagawa, R der Linden, PS Kartalaei, SA Camper, N Speck, E Dzierzak	Journal of Experimental Medicine	2013
Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo X Gao, KD Johnson, YI Chang, ME Boyer, CN Dewey, J Zhang, EH Bresnick	Journal of Experimental Medicine	2013
The evolution of cellular deficiency in GATA2 mutation RE Dickinson, P Milne, L Jardine, S Zandi, SI Swierczek, N McGovern, S Cookson, Z Ferozepurwalla, A Langridge, S Pagan, A Gennery, T Heiskanen-Kosma, S Hamalainen, M Seppanen, M Helbert, E Tholouli, E Gambineri, S Reykdal, M Gottfrethsson, JE Thaventhiran, E Morris, G Hirschfield, AG Richter, S Jolles, CM Bacon, S Hambleton, M Haniffa, Y Bryceson, C Allen, JT Prchal, JE Dick, V Bigley, M Collin	Blood	2013
Transcriptional Mechanisms Underlying Hemoglobin Synthesis KR Katsumura, AW DeVilbiss, NJ Pope, KD Johnson, EH Bresnick	Cold Spring Harbor Perspectives in Medicine	2013
Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism AP Hsu, KJ Sowerwine, MG Lawrence, J Davis, CJ Henderson, KA Zarember, M Garofalo, JI Gallin, DB Kuhns, T Heller, JD Milner, JM Puck, AF Freeman, SM Holland	Journal of Allergy and Clinical Immunology	2013
GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity MA Spinner, LA Sanchez, AP Hsu, PA Shaw, CS Zerbe, KR Calvo, DC Arthur, W Gu, CM Gould, CC Brewer, EW Cowen, AF Freeman, KN Olivier, G Uzel, AM Zelazny, JR Daub, CD Spalding, RJ Claypool, NK Giri, BP Alter, EM Mace, JS Orange, J Cuellar-Rodriguez, DD Hickstein, SM Holland	Blood	2013
Establishment of a cell-type-specific genetic network by the mediator complex component Med1 NJ Pope, EH Bresnick	Molecular and cellular biology	2013

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