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Usage Information

The molecular basis of T cell acute lymphoblastic leukemia
Pieter Van Vlierberghe, Adolfo Ferrando
Pieter Van Vlierberghe, Adolfo Ferrando
Published October 1, 2012
Citation Information: J Clin Invest. 2012;122(10):3398-3406. https://doi.org/10.1172/JCI61269.
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Review Series Article has an altmetric score of 26

The molecular basis of T cell acute lymphoblastic leukemia

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Abstract

T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL.

Authors

Pieter Van Vlierberghe, Adolfo Ferrando

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