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Citations to this article

CD4+ T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease
Antonella De Luca, … , Jean-Paul Latgé, Luigina Romani
Antonella De Luca, … , Jean-Paul Latgé, Luigina Romani
Published April 23, 2012
Citation Information: J Clin Invest. 2012;122(5):1816-1831. https://doi.org/10.1172/JCI60862.
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Research Article Article has an altmetric score of 6

CD4+ T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease

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Abstract

Aspergillus fumigatus is a model fungal pathogen and a common cause of infection in individuals with the primary immunodeficiency chronic granulomatous disease (CGD). Although primarily considered a deficiency of innate immunity, CGD is also linked to dysfunctional T cell reactivity. Both CD4+ and CD8+ T cells mediate vaccine-induced protection from experimental aspergillosis, but the molecular mechanisms leading to the generation of protective immunity and whether these mechanisms are dysregulated in individuals with CGD have not been determined. Here, we show that activation of either T cell subset in a mouse model of CGD is contingent upon the nature of the fungal vaccine, the involvement of distinct innate receptor signaling pathways, and the mode of antigen routing and presentation in DCs. Aspergillus conidia activated CD8+ T cells upon sorting to the Rab14+ endosomal compartment required for alternative MHC class I presentation. Cross-priming of CD8+ T cells failed to occur in mice with CGD due to defective DC endosomal alkalinization and autophagy. However, long-lasting antifungal protection and disease control were successfully achieved upon vaccination with purified fungal antigens that activated CD4+ T cells through the endosome/lysosome pathway. Our study thus indicates that distinct intracellular pathways are exploited for the priming of CD4+ and CD8+ T cells to A. fumigatus and suggests that CD4+ T cell vaccination may be able to overcome defective antifungal CD8+ T cell memory in individuals with CGD.

Authors

Antonella De Luca, Rossana G. Iannitti, Silvia Bozza, Remi Beau, Andrea Casagrande, Carmen D’Angelo, Silvia Moretti, Cristina Cunha, Gloria Giovannini, Cristina Massi-Benedetti, Agostinho Carvalho, Louis Boon, Jean-Paul Latgé, Luigina Romani

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Total citations by year

Year: 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Total
Citations: 1 1 2 2 2 3 3 5 3 5 6 5 38
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Citations to this article (38)

Title and authors Publication Year
Fungal vaccines and adjuvants: a tool to reveal the interaction between host and fungi.
Wang Z, Shao J
Archives of Microbiology 2024
Chenopodium murale Juice Shows Anti-Fungal Efficacy in Experimental Oral Candidiasis in Immunosuppressed Rats in Relation to Its Chemical Profile
El-Newary SA, Abd Elkarim AS, Abdelwahed NA, Omer EA, Elgamal AM, ELsayed WM
Molecules (Basel, Switzerland) 2023
Anakinra Activates Superoxide Dismutase 2 to Mitigate Inflammasome Activity
M Pariano, S Pieroni, AD Luca, RG Iannitti, M Borghi, M Puccetti, S Giovagnoli, G Renga, F DOnofrio, MM Bellet, C Stincardini, MA Della-Fazia, G Servillo, FL van de Veerdonk, C Costantini, L Romani
International journal of molecular sciences 2021
A Shifted Composition of the Lung Microbiota Conditions the Antifungal Response of Immunodeficient Mice
E Nunzi, G Renga, M Palmieri, G Pieraccini, M Pariano, C Stincardini, F DOnofrio, I Santarelli, MM Bellet, A Bartoli, C Costantini, L Romani
International journal of molecular sciences 2021
Crosstalk Between Autophagy and Hypoxia-Inducible Factor-1α in Antifungal Immunity
T Quäschling, D Friedrich, GS Deepe, J Rupp
Cells 2020
Tryptophan as a Central Hub for Host/Microbial Symbiosis
M Borghi, M Puccetti, M Pariano, G Renga, C Stincardini, M Ricci, S Giovagnoli, C Costantini, L Romani
International journal of tryptophan research : IJTR 2020
Aspergillus fumigatus and Aspergillosis in 2019
JP Latgé, G Chamilos
Clinical microbiology reviews 2019
Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease
G Renga, V Oikonomou, S Moretti, C Stincardini, MM Bellet, M Pariano, A Bartoli, S Brancorsini, P Mosci, A Finocchi, P Rossi, C Costantini, E Garaci, AL Goldstein, L Romani
2019
Methods of Controlling Invasive Fungal Infections Using CD8+ T Cells
PR Kumaresan, TA da Silva, DP Kontoyiannis
Frontiers in immunology 2018
Leucine-Rich Repeat Kinase 2 Controls the Ca2+/Nuclear Factor of Activated T Cells/IL-2 Pathway during Aspergillus Non-Canonical Autophagy in Dendritic Cells
AY Wong, V Oikonomou, G Paolicelli, AD Luca, M Pariano, J Fric, HS Tay, P Ricciardi-Castagnoli, T Zelante
Frontiers in immunology 2018
Autophagy in dendritic cells
G Ghislat, T Lawrence
Cellular and Molecular Immunology 2018
Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis
L Romani, V Oikonomou, S Moretti, RG Iannitti, MC D'Adamo, VR Villella, M Pariano, L Sforna, M Borghi, MM Bellet, F Fallarino, MT Pallotta, G Servillo, E Ferrari, P Puccetti, G Kroemer, M Pessia, L Maiuri, AL Goldstein, E Garaci
Nature Medicine 2017
Aspergillus fumigatus morphology and dynamic host interactions
FL van de Veerdonk, MS Gresnigt, L Romani, MG Netea, JP Latgé
Nature Reviews Microbiology 2017
Autophagy Proteins in Phagocyte Endocytosis and Exocytosis
C Münz
Frontiers in immunology 2017
IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis
RG Iannitti, V Napolioni, V Oikonomou, AD Luca, C Galosi, M Pariano, C Massi-Benedetti, M Borghi, M Puccetti, V Lucidi, C Colombo, E Fiscarelli, C Lass-Flörl, F Majo, L Cariani, M Russo, L Porcaro, G Ricciotti, H Ellemunter, L Ratclif, FM de Benedictis, VN Talesa, CA Dinarello, FL van de Veerdonk, L Romani
Nature Communications 2016
Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1
V Oikonomou, S Moretti, G Renga, C Galosi, M Borghi, M Pariano, M Puccetti, CA Palmerini, L Amico, A Carotti, L Prezioso, A Spolzino, A Finocchi, P Rossi, A Velardi, F Aversa, V Napolioni, L Romani
Cell Host & Microbe 2016
NOX2-dependent regulation of inflammation
KL Singel, BH Segal
Clinical Science 2016
Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis
K Cadwell
Nature Reviews Immunology 2016
Lipid peroxidation causes endosomal antigen release for cross-presentation
I Dingjan, DR Verboogen, LM Paardekooper, NH Revelo, SP Sittig, LJ Visser, GF von Mollard, SS Henriet, CG Figdor, M Beest, G Bogaart
Scientific Reports 2016
Insights into primary immune deficiency from quantitative microscopy
EM Mace, JS Orange
Journal of Allergy and Clinical Immunology 2015
Autophagy and autophagy-related proteins in the immune system
ST Shibutani, T Saitoh, H Nowag, C Münz, T Yoshimori
Nature Immunology 2015
Differential use of autophagy by primary dendritic cells specialised in cross-presentation
JD Mintern, C Macri, WJ Chin, SE Panozza, E Segura, NL Patterson, P Zeller, D Bourges, S Bedoui, PJ McMillan, A Idris, CJ Nowell, A Brown, K Radford, AP Johnston, JA Villadangos
Autophagy 2015
Inflammatory Monocytes Orchestrate Innate Antifungal Immunity in the Lung
V Espinosa, A Jhingran, O Dutta, S Kasahara, R Donnelly, P Du, J Rosenfeld, I Leiner, CC Chen, Y Ron, TM Hohl, A Rivera, DC Sheppard
PLoS pathogens 2014
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SG Nanjappa, BS Klein
Current Opinion in Immunology 2014
Innate Defense against Fungal Pathogens
RA Drummond, SL Gaffen, AG Hise, GD Brown
Cold Spring Harbor Perspectives in Medicine 2014
Antifungal Th Immunity: Growing up in Family
M Borghi, G Renga, M Puccetti, V Oikonomou, M Palmieri, C Galosi, A Bartoli, L Romani
Frontiers in immunology 2014
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
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Proceedings of the National Academy of Sciences 2014
sPD1-based DNA vaccine amplifies HIV-1 CD8+ T cells in mice
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Journal of Clinical Investigation 2013
Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice
MJ Grimm, RR Vethanayagam, NG Almyroudis, CG Dennis, AN Khan, AC D'Auria, KL Singel, BA Davidson, PR Knight, TS Blackwell, TM Hohl, MK Mansour, JM Vyas, M Röhm, CF Urban, T Kelkka, R Holmdahl, BH Segal
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