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Citations to this article

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease
Azeb Tadesse Argaw, … , Michael V. Sofroniew, Gareth R. John
Azeb Tadesse Argaw, … , Michael V. Sofroniew, Gareth R. John
Published June 1, 2012
Citation Information: J Clin Invest. 2012;122(7):2454-2468. https://doi.org/10.1172/JCI60842.
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Research Article Neuroscience Article has an altmetric score of 9

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

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Abstract

In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed. Disruption of the blood-brain barrier (BBB) is an early feature of lesion formation that correlates with clinical exacerbation, leading to edema, excitotoxicity, and entry of serum proteins and inflammatory cells. Here, we identify astrocytic expression of VEGF-A as a key driver of BBB permeability in mice. Inactivation of astrocytic Vegfa expression reduced BBB breakdown, decreased lymphocyte infiltration and neuropathology in inflammatory and demyelinating lesions, and reduced paralysis in a mouse model of MS. Knockdown studies in CNS endothelium indicated activation of the downstream effector eNOS as the principal mechanism underlying the effects of VEGF-A on the BBB. Systemic administration of the selective eNOS inhibitor cavtratin in mice abrogated VEGF-A–induced BBB disruption and pathology and protected against neurologic deficit in the MS model system. Collectively, these data identify blockade of VEGF-A signaling as a protective strategy to treat inflammatory CNS disease.

Authors

Azeb Tadesse Argaw, Linnea Asp, Jingya Zhang, Kristina Navrazhina, Trinh Pham, John N. Mariani, Sean Mahase, Dipankar J. Dutta, Jeremy Seto, Elisabeth G. Kramer, Napoleone Ferrara, Michael V. Sofroniew, Gareth R. John

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2010 2009 Total
Citations: 15 34 29 47 44 45 19 30 30 15 34 17 22 2 1 1 385
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International journal of molecular sciences 2022
Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities
Araújo B, Caridade-Silva R, Soares-Guedes C, Martins-Macedo J, Gomes ED, Monteiro S, Teixeira FG
Cells 2022
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice
Barisano G, Kisler K, Wilkinson B, Nikolakopoulou AM, Sagare AP, Wang Y, Gilliam W, Huuskonen MT, Hung ST, Ichida JK, Gao F, Coba MP, Zlokovic BV
Journal of Experimental Medicine 2022
Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling
Sun Z, Zhao H, Fang D, Davis CT, Shi DS, Lei K, Rich BE, Winter JM, Guo L, Sorensen LK, Pryor RJ, Zhu N, Lu S, Dickey LL, Doty DJ, Tong Z, Thomas KR, Mueller AL, Grossmann AH, Zhang B, Lane TE, Fujinami RS, Odelberg SJ, Zhu W
Neuron 2022
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin.
Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES
Nature Communications 2022
Short histological kaleidoscope – recent findings in histology. Part I
Constantin AM, Mihu CM, Boşca AB, Melincovici CS, Mărginean MV, Jianu EM, Ştefan RA, Alexandru BC, Moldovan IM, Şovrea AS, Sufleţel RT
Romanian Journal of Morphology and Embryology 2022
The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice
Reagan AM, Christensen KE, Graham LC, Bedwell AA, Eldridge K, Speedy R, Figueiredo LL, Persohn SC, Bottiglieri T, Nho K, Sasner M, Territo PR, Rozen R, Howell GR
Journal of Cerebral Blood Flow & Metabolism 2022
Manipulation of the diet–microbiota–brain axis in Alzheimer’s disease
Lee D, Lee VM, Hur SK
Frontiers in neuroscience 2022
Chronic oligodendrocyte injury in central nervous system pathologies
Molina-Gonzalez I, Miron VE, Antel JP
2022
Intricate role of sleep deprivation in modulating depression: focusing on BDNF, VEGF, serotonin, cortisol, and TNF-α.
Vaseghi S, Mostafavijabbari A, Alizadeh MS, Ghaffarzadegan R, Kholghi G, Zarrindast MR
Metabolic Brain Disease 2022
The Crosstalk between the Blood–Brain Barrier Dysfunction and Neuroinflammation after General Anaesthesia
Yang X, Chen X
Current issues in molecular biology 2022
Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease
Saavedra J, Nascimento M, Liz MA, Cardoso I
Frontiers in Cell and Developmental Biology 2022
The role of circadian clock in astrocytes: From cellular functions to ischemic stroke therapeutic targets.
Zhang Y, Zhao X, Zhang Y, Zeng F, Yan S, Chen Y, Li Z, Zhou D, Liu L
Frontiers in neuroscience 2022
Parasite infections, neuroinflammation, and potential contributions of gut microbiota
Alloo J, Leleu I, Grangette C, Pied S
Frontiers in immunology 2022
Patching Up the Permeability: The Role of Stem Cells in Lessening Neurovascular Damage in Amyotrophic Lateral Sclerosis
Monsour M, Garbuzova-Davis S, Borlongan CV
Stem Cells Translational Medicine 2022
Blood vessel remodeling in the cerebral cortex induced by binge alcohol intake in mice
Hasegawa H, Tanaka T, Kondo M, Teramoto K, Nakayama K, Hwang GW
Toxicological Research 2022
Developing a transwell millifluidic device for studying blood-brain barrier endothelium.
Harding IC, O'Hare NR, Vigliotti M, Caraballo A, Lee CI, Millican K, Herman IM, Ebong EE
Lab on a chip 2022
Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation
Miguel A. Lopez-Ramirez, Catherine C. Lai, Shady I. Soliman, Preston Hale, Angela Pham, Esau J. Estrada, Sara McCurdy, Romuald Girard, Riya Verma, Thomas Moore, Rhonda Lightle, Nicholas Hobson, Robert Shenkar, Orit Poulsen, Gabriel G. Haddad, Richard Daneman, Brendan Gongol, Hao Sun, Frederic Lagarrigue, Issam A. Awad, Mark H Ginsberg
Journal of Clinical Investigation 2021
Attenuation of cerebral edema facilitates recovery of glymphatic system function after Status Epilepticus
Kewei Liu, Juan Zhu, Yuan Chang, Zhenzhou Lin, Zhu Shi, Xing Li, Xing Chen, Chuman Lin, Suyue Pan, Kaibin Huang
JCI Insight 2021
Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation
PN Bernatchez, B Tao, RA Bradshaw, D Eveleth, WC Sessa
Translational Vision Science & Technology 2021
Glymphatic System in the Central Nervous System, a Novel Therapeutic Direction Against Brain Edema After Stroke
X Zhou, Y Li, C Lenahan, Y Ou, M Wang, Y He
Frontiers in aging neuroscience 2021
Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview
SR Archie, AA Shoyaib, L Cucullo
Pharmaceutics 2021
Age‐related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review
B Zimmerman, B Rypma, G Gratton, M Fabiani
Psychophysiology 2021
Repair Mechanisms of the Neurovascular Unit after Ischemic Stroke with a Focus on VEGF
S Moon, MS Chang, SH Koh, YK Choi
International journal of molecular sciences 2021
Astrocyte Gliotransmission in the Regulation of Systemic Metabolism
CD Murat, C García-Cáceres
Metabolites 2021
Activation and Role of Astrocytes in Ischemic Stroke
XY Shen, ZK Gao, Y Han, M Yuan, YS Guo, X Bi
Frontiers in cellular neuroscience 2021
Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
X Peng, Z Luo, S He, L Zhang, Y Li
Frontiers in Cellular and Infection Microbiology 2021
Mesenchymal Stem/Stromal Cell Therapy in Blood–Brain Barrier Preservation Following Ischemia: Molecular Mechanisms and Prospects
PT Do, CC Wu, YH Chiang, CJ Hu, KY Chen
International journal of molecular sciences 2021
The interplay of neurovasculature and adult hippocampal neurogenesis
TA Kim, L Chen, S Ge
Neuroscience Letters 2021
Microarray profiling predicts early neurological and immune phenotypic traits in advance of CNS disease during disease progression in Trypanosoma. b. brucei infected CD1 mouse brains
P Montague, B Bradley, J Rodgers, PG Kennedy, MA Phillips
PLoS neglected tropical diseases 2021
Not Just a Bystander: The Emerging Role of Astrocytes and Research Tools in Studying Cognitive Dysfunctions in Schizophrenia
CY Chang, DZ Luo, JC Pei, MC Kuo, YC Hsieh, WS Lai
International journal of molecular sciences 2021
Enteral enriched nutrition to prevent cognitive dysfunction after surgery; a study in rats
IB Hovens, BL van Leeuwen, J Falcao-Salles, JJ de Haan, RG Schoemaker
2021
Neuroinflammation in Autoimmune Disease and Primary Brain Tumors: The Quest for Striking the Right Balance
D Mitchell, J Shireman, EA Potchanant, M Lara-Velazquez, M Dey
Frontiers in cellular neuroscience 2021
Connecting Neuroinflammation and Neurodegeneration in Multiple Sclerosis: Are Oligodendrocyte Precursor Cells a Nexus of Disease?
MW Psenicka, BC Smith, RA Tinkey, JL Williams
Frontiers in cellular neuroscience 2021
Microglia Regulate Neuronal Circuits in Homeostatic and High-Fat Diet-Induced Inflammatory Conditions
XL Wang, L Li
Frontiers in cellular neuroscience 2021
Hypothalamic Microglial Heterogeneity and Signature under High Fat Diet–Induced Inflammation
NF Mendes, CP Jara, AM Zanesco, EP de Araújo
International journal of molecular sciences 2021
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
T Gruber, C Pan, RE Contreras, T Wiedemann, DA Morgan, AA Skowronski, S Lefort, CD Murat, OL Thuc, B Legutko, FJ Ruiz-Ojeda, M de la Fuente-Fernández, AL García-Villalón, D González-Hedström, M Huber, K Szigeti-Buck, TD Müller, S Ussar, P Pfluger, SC Woods, A Ertürk, CA LeDuc, K Rahmouni, M Granado, TL Horvath, MH Tschöp, C García-Cáceres
Cell Metabolism 2021
Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation
JR Dayton, Y Yuan, LP Pacumio, BG Dorflinger, SC Yoo, MJ Olson, SI Hernández-Suárez, MM McMahon, L Cruz-Orengo
Frontiers in cellular neuroscience 2021
Sequential perturbations to mouse corticogenesis following in utero maternal immune activation
CP Canales, ML Estes, K Cichewicz, K Angara, JP Aboubechara, S Cameron, K Prendergast, L Su-Feher, I Zdilar, EJ Kreun, EC Connolly, JM Seo, JB Goon, K Farrelly, TW Stradleigh, D van der List, L Haapanen, JV de Water, D Vogt, AK McAllister, AS Nord
eLife 2021
Progress in mimicking brain microenvironments to understand and treat neurological disorders
MT Ngo, BA Harley
2021
Neuroinflammatory Response to TNFα and IL1β Cytokines Is Accompanied by an Increase in Glycolysis in Human Astrocytes In Vitro
D Pamies, C Sartori, D Schvartz, V González-Ruiz, L Pellerin, C Nunes, D Tavel, V Maillard, J Boccard, S Rudaz, JC Sanchez, MG Zurich
International journal of molecular sciences 2021
Exploring cannabidiol effects on inflammatory markers in individuals with cocaine use disorder: a randomized controlled trial
F Morissette, V Mongeau-Pérusse, E Rizkallah, P Thébault, S Lepage, S Brissette, J Bruneau, S Dubreucq, E Stip, JF Cailhier, D Jutras-Aswad
Neuropsychopharmacology 2021
CytoTalk: De novo construction of signal transduction networks using single-cell transcriptomic data
Y Hu, T Peng, L Gao, K Tan
Science Advances 2021
Astrocyte-specific hypoxia-inducible factor 1 (HIF-1) does not disrupt the endothelial barrier during hypoxia in vitro
J Baumann, CC Tsao, SF Huang, M Gassmann, OO Ogunshola
Fluids and barriers of the CNS 2021
Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?
Y Qiu, C Zhang, A Chen, H Wang, Y Zhou, Y Li, B Hu
Frontiers in immunology 2021
Role of ginseng in the neurovascular unit of neuroinflammatory diseases focused on the blood-brain barrier
M Kim, H Mok, WS Yeo, JH Ahn, YK Choi
Journal of Ginseng Research 2021
VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody
L Micheli, C Parisio, E Lucarini, A Vona, A Toti, A Pacini, T Mello, S Boccella, F Ricciardi, S Maione, G Graziani, PM Lacal, P Failli, C Ghelardini, LD Mannelli
Journal of Experimental & Clinical Cancer Research 2021
Using quantitative MRI to study brain responses to immune challenge with interferon-α
MA Nettis, AJ Lawrence, T Wood, N Mariani, N Nikkheslat, G Lombardo, D Enache, M Veronese, FE Turkheimer, P Dazzan, CM Pariante, V Mondelli
2021
Effects of RORγt overexpression on the murine central nervous system
T Sasaki, R Nagata, S Takahashi, Y Takei
2021
Transcriptome Differences in Pig Tracheal Epithelial Cells in Response to Pasteurella Multocida Infection
X Wang, F Wang, L Lin, W Liang, S Liu, L Hua, X Wang, H Chen, Z Peng, B Wu
Frontiers in Veterinary Science 2021
Review article for CTR special issue edited by C. Schachtrup Title of Special Issue: “Modulating scar formation for improving brain repair” Loss-of-function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation
S Wahane, MV Sofroniew
Cell and Tissue Research 2021
Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation
DJ Lundy, H Nguyễn, PC Hsieh
Pharmaceutics 2021
Neuroinflammation: Integrated Nervous Tissue Response through Intercellular Interactions at the “Whole System” Scale
D Nosi, D Lana, MG Giovannini, G Delfino, S Zecchi-Orlandini
Cells 2021
Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder
S Wu, Y Yin, L Du
Cellular and Molecular Neurobiology 2021
Astrocyte–Endotheliocyte Axis in the Regulation of the Blood–Brain Barrier
A Pivoriūnas, A Verkhratsky
Neurochemical Research 2021
Dichotomy in Growth and Invasion from Low- to High-Grade Glioma Cellular Variants
K Ghosh, S Ghosh, U Chatterjee, P Bhattacharjee, A Ghosh
Cellular and Molecular Neurobiology 2021
Protective Effects of Cannabidivarin and Cannabigerol on Cells of the Blood–Brain Barrier Under Ischemic Conditions
NL Stone, TJ England, SE O'Sullivan
Cannabis and Cannabinoid Research 2021
Transcryptomic Analysis of Human Brain-Microvascular Endothelial Response to -Pericytes: Cell Orientation Defines Barrier Function
L Kurmann, M Okoniewski, OO Ogunshola, B Leeners, B Imthurn, RK Dubey
Cells 2021
Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies
X Xiao, S Huang, S Chen, Y Wang, Q Sun, X Xu, Y Li
Journal of Experimental & Clinical Cancer Research 2021
Hypothalamic inflammation in metabolic disorders and aging
A Bhusal, H Rahman, K Suk
Cellular and Molecular Life Sciences 2021
Korean Red Ginseng Improves Astrocytic Mitochondrial Function by Upregulating HO-1-Mediated AMPKα–PGC-1α–ERRα Circuit after Traumatic Brain Injury
M Kim, J Kim, S Moon, BY Choi, S Kim, HS Jeon, SW Suh, YM Kim, YK Choi
International journal of molecular sciences 2021
Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver
GH Buniatian, R Weiskirchen, TS Weiss, U Schwinghammer, M Fritz, T Seferyan, B Proksch, M Glaser, A Lourhmati, M Buadze, E Borkham-Kamphorst, F Gaunitz, CH Gleiter, T Lang, E Schaeffeler, R Tremmel, H Cynis, WH Frey, R Gebhardt, SL Friedman, W Mikulits, M Schwab, L Danielyan
Cells 2020
Blood–brain barrier genetic disruption leads to protective barrier formation at the Glia Limitans
P Mora, PL Hollier, S Guimbal, A Abelanet, A Diop, L Cornuault, T Couffinhal, S Horng, AP Gadeau, MA Renault, C Chapouly, R Daneman
PLoS Biology 2020
Astrocyte-derived VEGF increases cerebral microvascular permeability under high salt conditions
Z Deng, L Zhou, Y Wang, S Liao, Y Huang, Y Shan, S Tan, Q Zeng, L Peng, H Huang, Z Lu
Aging 2020
The blood–brain barrier in health and disease: Important unanswered questions
CP Profaci, RN Munji, RS Pulido, R Daneman
Journal of Experimental Medicine 2020
Cellular and Molecular Mechanisms of Spinal Cord Vascularization
JR Vieira, B Shah, CR de Almodovar
Frontiers in physiology 2020
Biphasic roles of pentraxin 3 in cerebrovascular function after white matter stroke
A Shindo, H Takase, Hamanaka, KK Chung, ET Mandeville, N Egawa, T Maki, M Borlongan, R Takahashi, J Lok, H Tomimoto, EH Lo, K Arai
CNS Neuroscience & Therapeutics 2020
Astrocytes are necessary for blood–brain barrier maintenance in the adult mouse brain
BP Heithoff, KK George, AN Phares, IA Zuidhoek, C MunozBallester, S Robel
Glia 2020
Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain
SI Graves, DJ Baker
Basic & Clinical Pharmacology & Toxicology 2020
Overview of Crosstalk Between Multiple Factor of Transcytosis in Blood Brain Barrier
M Tjakra, Y Wang, V Vania, Z Hou, C Durkan, N Wang, G Wang
Frontiers in neuroscience 2020
Blood biomarkers for neonatal hypoxic–ischemic encephalopathy in the presence and absence of sentinel events
EK Broni, AC Eke, D Vaidya, X Tao, FJ Northington, AD Everett, EM Graham
Journal of Perinatology 2020
Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders
M Xiao, ZJ Xiao, B Yang, Z Lan, F Fang
Frontiers in neuroscience 2020
Regenerative Potential of Carbon Monoxide in Adult Neural Circuits of the Central Nervous System
E Jung, SH Koh, M Yoo, YK Choi
International journal of molecular sciences 2020
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier
J Hauptmann, L Johann, F Marini, M Kitic, E Colombo, IA Mufazalov, M Krueger, K Karram, S Moos, F Wanke, FC Kurschus, M Klein, S Cardoso, J Strauß, S Bolisetty, F Lühder, M Schwaninger, H Binder, I Bechman, T Bopp, A Agarwal, MP Soares, T Regen, A Waisman
Acta Neuropathologica 2020
An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration
R Dabouz, CW Cheng, P Abram, S Omri, G Cagnone, KV Sawmy, JS Joyal, M Desjarlais, D Olson, AG Weil, W Lubell, JC Rivera, S Chemtob
Journal of Neuroinflammation 2020
The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target
T Okada, H Suzuki, ZD Travis, JH Zhang
Current neuropharmacology 2020
Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury
Y Zhou, A Shao, Y Yao, S Tu, Y Deng, J Zhang
Cell Communication and Signaling 2020
Interaction of Microglia and Astrocytes in the Neurovascular Unit
L Liu, J Liu, J Bao, Q Bai, G Wang
Frontiers in immunology 2020
Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation
Iva Bozic, Danijela Savic, Irena Lavrnja
Histology and histopathology 2020
Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity
MV Sofroniew
Trends in Immunology 2020
Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases
L Li, C Acioglu, RF Heary, S Elkabes
Brain, Behavior, and Immunity 2020
Cytokines in CAR T Cell–Associated Neurotoxicity
J Gust, R Ponce, WC Liles, GA Garden, CJ Turtle
Frontiers in immunology 2020
Basic physiology of the blood-brain barrier in health and disease: a brief overview
M Kaya, B Ahishali
Tissue Barriers 2020
Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome
AA Sher, A Gao, KM Coombs
Cells 2020
Embryonic Heat Conditioning Induces TET-Dependent Cross-Tolerance to Hypothalamic Inflammation Later in Life
T Rosenberg, T Kisliouk, T Cramer, D Shinder, S Druyan, N Meiri
Frontiers in Genetics 2020
Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B
A Grover, D Crippen-Harmon, L Nave, J Vincelette, JC Wait, AC Melton, R Lawrence, JR Brown, KA Webster, BK Yip, B Baridon, C Vitelli, S Rigney, TM Christianson, PM Tiger, MJ Lo, J Holtzinger, AJ Shaywitz, BE Crawford, PA Fitzpatrick, JH LeBowitz, S Bullens, M Aoyagi-Scharber, S Bunting, CA ONeill, J Pinkstaff, A Bagri
Drug Delivery and Translational Research 2020
Kir4.1 potassium channel regulation via microRNA-205 in astrocytes exposed to hyperglycemic conditions
DE Rivera-Aponte, KV Melnik-Martínez, CJ Malpica-Nieves, F Tejeda-Bayron, MP Méndez-González, SN Skatchkov, MJ Eaton
NeuroReport 2020
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
L Zhao, Z Li, JS Vong, X Chen, HM Lai, LY Yan, J Huang, SK Sy, X Tian, Y Huang, HY Chan, HC So, WL Ng, Y Tang, WJ Lin, VC Mok, H Ko
Nature Communications 2020
Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia
FS Giorgi, F Biagioni, A Galgani, N Pavese, G Lazzeri, F Fornai
International journal of molecular sciences 2020
Astrocyte Crosstalk in CNS Inflammation
M Linnerbauer, MA Wheeler, FJ Quintana
Neuron 2020
Hypoxic‐ischemic‐related cerebrovascular changes and potential therapeutic strategies in the neonatal brain
C Disdier, BS Stonestreet
Journal of Neuroscience Research 2020
Materials for blood brain barrier modeling in vitro
MP Ferro, SC Heilshorn, RM Owens
Materials science & engineering. R, Reports : a review journal 2020
Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure
JS Meabon, DG Cook, M Yagi, GE Terry, DJ Cross, M Muzi, KF Pagulayan, AF Logsdon, AG Schindler, V Ghai, K Wang, S Fallen, Y Zhou, TK Kim, I Lee, WA Banks, ES Carlson, C Mayer, RC Hendrickson, MA Raskind, DA Marshall, DP Perl, CD Keene, ER Peskind
Journal of the Neurological Sciences 2020
Genes that Mediate Metastasis across the Blood–Brain Barrier
J Fares, D Kanojia, A Rashidi, I Ulasov, MS Lesniak
Trends in Cancer 2020
Monoclonal Antibody-Based Treatments for Neuromyelitis Optica Spectrum Disorders: From Bench to Bedside
W Zhu, Y Zhang, Z Wang, Y Fu, Y Yan
Neuroscience Bulletin 2020
Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms
X Huang, B Hussain, J Chang
CNS Neuroscience & Therapeutics 2020
Affective Immunology: The Crosstalk Between Microglia and Astrocytes Plays Key Role?
L Yang, Y Zhou, H Jia, Y Qi, S Tu, A Shao
Frontiers in immunology 2020
Hypertonic saline mediates the NLRP3/IL‐1β signaling axis in microglia to alleviate ischemic blood‐brain barrier permeability by downregulating astrocyte‐derived VEGF in rats
Q Wang, H Ding, S Chen, X Liu, Y Deng, W Jiang, Y Li, L Huang, Y Han, M Wen, M Wang, H Zeng
CNS Neuroscience & Therapeutics 2020
Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1
J Xu, T Zhan, W Zheng, YK Huang, K Chen, XH Zhang, P Ren,
Acta Cirurgica Brasileira 2020
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1α/VEGF Signaling and Blood–Brain Barrier Integrity
X Yang, Y Zhang, K Geng, K Yang, J Shao, W Xia
Cellular and Molecular Neurobiology 2020
Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation
R Gamage, I Wagnon, I Rossetti, R Childs, G Niedermayer, R Chesworth, E Gyengesi
Frontiers in cellular neuroscience 2020
Ammonia-Induced Glial-Inflammaging
LD Bobermin, RH Roppa, CA Gonçalves, A Quincozes-Santos
Molecular Neurobiology 2020
Maintenance of Tight Junction Integrity in the Absence of Vascular Dilation in the Brain of Mice Exposed to Ultra-High-Dose-Rate FLASH Irradiation
Barrett D Allen, Munjal M Acharya, Pierre Montay-Gruel, Patrik Goncalves Jorge, Claude Bailat, Benoît Petit, Marie-Catherine Vozenin, Charles Limoli
Radiation Research 2020
Cellular Contributors to Hypothalamic Inflammation in Obesity
Chan Hee Lee, Kyoungho Suk, Rina Yu, Min-Seon Kim
Molecules and Cells 2020
Theta-burst transcranial magnetic stimulation promotes stroke recovery by vascular protection and neovascularization
X Zong, Y Li, C Liu, W Qi, D Han, L Tucker, Y Dong, S Hu, X Yan, Q Zhang
Theranostics 2020
PRDM16 orchestrates angiogenesis via neural differentiation in the developing brain
L Su, X Lei, H Ma, C Feng, J Jiang, J Jiao
Cell Death and Differentiation 2020
Blood-Brain Barrier: From Physiology to Disease and Back
MD Sweeney, Z Zhao, A Montagne, AR Nelson, BV Zlokovic
Physiological reviews 2019
Hypertonic saline downregulates endothelial cell-derived VEGF expression and reduces blood-brain barrier permeability induced by cerebral ischaemia via the VEGFR2/eNOS pathway
Q Wang, Y Deng, L Huang, W Zeng, S Chen, B Lv, W Jiang, Y Han, H Ding, M Wen, H Zeng
International journal of molecular medicine 2019
The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke
Y Shan, S Tan, Y Lin, S Liao, B Zhang, X Chen, J Wang, Z Deng, Q Zeng, L Zhang, Y Wang, X Hu, W Qiu, L Peng, Z Lu
Journal of Neuroinflammation 2019
Tanycyte-Independent Control of Hypothalamic Leptin Signaling
S Yoo, D Cha, DW Kim, TV Hoang, S Blackshaw
Frontiers in neuroscience 2019
Coordinated expression of vascular endothelial growth factor A and urokinase-type plasminogen activator contributes to classical swine fever virus Shimen infection in macrophages
X Gong, A Hu, X Li, J He, Z Wu, , P Ning
BMC veterinary research 2019
The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis
R Brambilla
Acta Neuropathologica 2019
Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
KA Dudek, L DionAlbert, FN Kaufmann, E Tuck, M Lebel, C Menard
The European journal of neuroscience 2019
Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage
S Michinaga, Y Koyama
International journal of molecular sciences 2019
Significant response of low-dose apatinib monotherapy in brain metastases of triple-negative breast cancer: A case report
T Li, SB Wang, KJ Lei, MQ Jiang, YM Jia
Medicine 2019
Resistin-Inhibited Neural Stem Cell-Derived Astrocyte Differentiation Contributes to Permeability Destruction of the Blood–Brain Barrier
L Xiaoying, T Li, S Yu, J Jiusheng, Z Jilin, W Jiayi, L Dongxin, F Wengang, Z Xinyue, Y Hao, C Yuhua, S Deshu
Neurochemical Research 2019
Pathways Exploited by Flaviviruses to Counteract the Blood-Brain Barrier and Invade the Central Nervous System
YM Mustafá, LM Meuren, SV Coelho, LB de Arruda
Frontiers in microbiology 2019
Glutaric Acid Affects Pericyte Contractility and Migration: Possible Implications for GA-I Pathogenesis
E Isasi, N Korte, V Abudara, D Attwell, S Olivera-Bravo
Molecular Neurobiology 2019
Characterization of the Subventricular-Thalamo-Cortical Circuit in the NP-C Mouse Brain, and New Insights Regarding Treatment
MH Park, BJ Choi, MS Jeong, JY Lee, IK Jung, KH Park, HW Lee, T Yamaguchi, HH Marti, BH Lee, EH Schuchman, HK Jin, J Bae
Molecular Therapy 2019
Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model
SF Spampinato, S Merlo, E Fagone, M Fruciano, C Barbagallo, T Kanda, Y Sano, M Purrello, C Vancheri, M Ragusa, MA Sortino
Frontiers in cellular neuroscience 2019
Reactive Astrocytes in Neurodegenerative Diseases
K Li, J Li, J Zheng, S Qin
Aging and disease 2019
Central VEGF-A pathway plays a key role in the development of trigeminal neuropathic pain in rats
GW Lee, JY Son, AR Lee, JS Ju, YC Bae, DK Ahn
Molecular Pain 2019
The Blood–Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders
L Costea, Á Mészáros, H Bauer, HC Bauer, A Traweger, I Wilhelm, AE Farkas, IA Krizbai
International journal of molecular sciences 2019
Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood–Brain Barrier Integrity
SF Spampinato, V Bortolotto, PL Canonico, MA Sortino, M Grilli
Frontiers in pharmacology 2019
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
CD Arvanitis, GB Ferraro, RK Jain
Nature Reviews Cancer 2019
Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier
PV Dyken, B Lacoste
Frontiers in neuroscience 2018
Mechanisms of Blood-Brain Barrier Disruption in Herpes Simplex Encephalitis
H Liu, K Qiu, Q He, Q Lei, W Lu
Journal of Neuroimmune Pharmacology 2018
Sirt3 deficiency impairs neurovascular recovery in ischemic stroke
X Yang, KY Geng, YS Zhang, JF Zhang, K Yang, JX Shao, WL Xia
CNS Neuroscience & Therapeutics 2018
Real-time in vivo two-photon imaging study reveals decreased cerebro-vascular volume and increased blood-brain barrier permeability in chronically stressed mice
S Lee, BM Kang, JH Kim, J Min, HS Kim, H Ryu, H Park, S Bae, D Oh, M Choi, M Suh
Scientific Reports 2018
Cell-Based and Exosome Therapy in Diabetic Stroke: Cell-Based and Exosome Therapy in Diabetic Stroke
P Venkat, M Chopp, J Chen
Stem Cells Translational Medicine 2018
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
C Yang, KE Hawkins, S Dore, E Candelario-Jalil
American journal of physiology. Cell physiology 2018
Brain vascular heterogeneity: implications for disease pathogenesis and design of in vitro blood–brain barrier models
ME Noumbissi, B Galasso, MF Stins
Fluids and barriers of the CNS 2018
Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia
F Wang, Y Cao, L Ma, H Pei, WD Rausch, H Li
Frontiers in aging neuroscience 2018
Ginkgo biloba Extract Inhibits Astrocytic Lipocalin-2 Expression and Alleviates Neuroinflammatory Injury via the JAK2/STAT3 Pathway After Ischemic Brain Stroke
Y Zhang, J Liu, B Yang, Y Zheng, M Yao, M Sun, L Xu, C Lin, D Chang, F Tian
Frontiers in pharmacology 2018
Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy
M Fakhoury
Current neuropharmacology 2018
Rosuvastatin Reduces Neuroinflammation in the Hemorrhagic Transformation After rt-PA Treatment in a Mouse Model of Experimental Stroke
D Lu, Y Liu, H Mai, J Zang, L Shen, Y Zhang, A Xu
Frontiers in cellular neuroscience 2018
The role of TAM family receptors and ligands in the nervous system: From development to pathobiology
B Shafit-Zagardo, RC Gruber, JC DuBois
Pharmacology & Therapeutics 2018
A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke
Q Huang, W Zhong, Z Hu, X Tang
Journal of Neuroinflammation 2018
Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes
AF Logsdon, JS Meabon, MM Cline, KM Bullock, MA Raskind, ER Peskind, WA Banks, DG Cook
Scientific Reports 2018
Specific Alterations in Astrocyte Properties via the GluA2-GAPDH Complex Associated with Multiple Sclerosis
FH Lee, H Zhang, A Jiang, CC Zai, F Liu
Scientific Reports 2018
Heme oxygenase metabolites improve astrocytic mitochondrial function via a Ca2+-dependent HIF-1α/ERRα circuit
YK Choi, JH Park, JA Yun, JH Cha, Y Kim, MH Won, KW Kim, KS Ha, YG Kwon, YM Kim, H Shi
PloS one 2018
Bridging barriers: a comparative look at the blood–brain barrier across organisms
NM O'Brown, SJ Pfau, C Gu
Genes & development 2018
Connexin 43 Controls the Astrocyte Immunoregulatory Phenotype
AC Boulay, A Gilbert, VO Moreira, C Blugeon, S Perrin, J Pouch, SL Crom, B Ducos, M Cohen-Salmon
Brain Sciences 2018
Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain
MS Hernandes, B Lassègue, LL Hilenski, J Adams, N Gao, CY Kuan, YY Sun, L Cheng, DS Kikuchi, M Yepes, KK Griendling
Journal of Neuroinflammation 2018
Role of Carbon Monoxide in Neurovascular Repair Processing
YK Choi
Biomolecules & therapeutics 2018
Impaired Cerebral Perfusion in Multiple Sclerosis: Relevance of Endothelial Factors
L Monti, L Morbidelli, A Rossi
Biomarker insights 2018
Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood–Brain Barrier
M Kim, DJ Ma, D Calligaris, S Zhang, RW Feathers, RA Vaubel, I Meaux, AC Mladek, KE Parrish, F Jin, C Barriere, L Debussche, J Watters, S Tian, PA Decker, JE Eckel-Passow, GJ Kitange, AJ Johnson, IF Parney, PZ Anastasiadis, NY Agar, WF Elmquist, JN Sarkaria
Molecular cancer therapeutics 2018
Knockdown of HIF-1α impairs post-ischemic vascular reconstruction in the brain via deficient homing and sprouting bmEPCs: Knockdown of HIF-1α impairs post-ischemic vascular reconstruction
Y Liu, H Ran, Y Xiao, H Wang, Y Chen, W Chen, X Xu
Brain Pathology 2018
Drug Transport at the Brain and Endothelial Dysfunction in Preeclampsia: Implications and Perspectives
P Torres-Vergara, C Escudero, J Penny
Frontiers in physiology 2018
Activated T cells induce proliferation of oligodendrocyte progenitor cells via release of vascular endothelial cell growth factor-A
EH Choi, Y Xu, M Medynets, MC Monaco, EO Major, A Nath, T Wang
Glia 2018
Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat
S Hillebrand, K Schanda, M Nigritinou, I Tsymala, D Böhm, P Peschl, Y Takai, K Fujihara, I Nakashima, T Misu, M Reindl, H Lassmann, M Bradl
Acta Neuropathologica 2018
Regenerative Effects of Heme Oxygenase Metabolites on Neuroinflammatory Diseases
H Lee, Y Choi
International journal of molecular sciences 2018
Controversial roles for dexamethasone in glioblastoma – Opportunities for novel vascular targeting therapies
D Dubinski, E Hattingen, C Senft, V Seifert, KG Peters, Y Reiss, K Devraj, KH Plate
Journal of Cerebral Blood Flow & Metabolism 2018
Blood-brain barrier disruption and angiogenesis in a rat model for neurocysticercosis: XXXX
RP Carmen-Orozco, DG Dávila-Villacorta, Y Cauna, EG Bernal-Teran, L Bitterfeld, GL Sutherland, N Chile, RH Céliz, MC Ferrufino-Schmidt, CM Gavídia, CR Sterling, HH García, RH Gilman, MR Verástegui
Journal of Neuroscience Research 2018
Leukemia‐derived exosomes and cytokines pave the way for entry into the brain
I Kinjyo, D Bragin, R Grattan, SS Winter, BS Wilson
Journal of leukocyte biology 2018
Astrocytes to the rescue! Glia limitans astrocytic endfeet control CNS inflammation
Francisco J. Quintana
Journal of Clinical Investigation 2017
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis
Sam Horng, Anthony Therattil, Sarah Moyon, Alexandra Gordon, Karla Kim, Azeb Argaw, Yuko Hara, John Mariani, Setsu Sawai, Per Flodby, Edward D. Crandall, Zea Borok, Michael V Sofroniew, Candice Chapouly, Gareth John
Journal of Clinical Investigation 2017
Hypothalamic inflammation in obesity and metabolic disease
Alexander Jais, Jens Bruening
Journal of Clinical Investigation 2017
High Salt-Induced Activation and Expression of Inflammatory Cytokines in Cultured Astrocytes
Z Deng, Y Wang, L Zhou, Y Shan, S Tan, W Cai, S Liao, L Peng, Z Lu
Cell cycle (Georgetown, Tex.) 2017
Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis
JE Lengfeld, SE Lutz, JR Smith, C Diaconu, C Scott, SB Kofman, C Choi, CM Walsh, CS Raine, I Agalliu, D Agalliu
Proceedings of the National Academy of Sciences 2017
Response of the cerebral vasculature following traumatic brain injury
A Salehi, JH Zhang, A Obenaus
Journal of Cerebral Blood Flow & Metabolism 2017
Delayed histochemical alterations within the neurovascular unit due to transient focal cerebral ischemia and experimental treatment with neurotrophic factors
D Michalski, R Pitsch, DR Pillai, B Mages, S Aleithe, J Grosche, H Martens, F Schlachetzki, W Härtig, CV Borlongan
PloS one 2017
Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype
S Janelidze, J Hertze, K Nägga, K Nilsson, C Nilsson, M Wennström, D Westen, K Blennow, H Zetterberg, O Hansson
Neurobiology of Aging 2017
IFN‐γ promotes transendothelial migration of CD4 + T cells across the blood–brain barrier
SA Sonar, S Shaikh, N Joshi, AN Atre, G Lal
Immunology and Cell Biology 2017
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations
MA Lopez-Ramirez, G Fonseca, HA Zeineddine, R Girard, T Moore, A Pham, Y Cao, R Shenkar, BJ Kreuk, F Lagarrigue, J Lawler, CK Glass, IA Awad, MH Ginsberg
Journal of Experimental Medicine 2017
Contemporary Approaches to Modulating the Nitric Oxide–cGMP Pathway in Cardiovascular Disease
JR Kraehling, WC Sessa
Circulation research 2017
Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes
SS Dusaban, J Chun, H Rosen, NH Purcell, JH Brown
Journal of Neuroinflammation 2017
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties
CK Prajeeth, J Kronisch, R Khorooshi, B Knier, H Toft-Hansen, V Gudi, S Floess, J Huehn, T Owens, T Korn, M Stangel
Journal of Neuroinflammation 2017
Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124–2HG
R Huang, Y Zhang, B Han, Y Bai, R Zhou, G Gan, J Chao, G Hu, H Yao
Autophagy 2017
Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis
S Brilha, CW Ong, B Weksler, N Romero, PO Couraud, JS Friedland
Scientific Reports 2017
Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
H Gao, MC Danzi, CS Choi, M Taherian, C Dalby-Hansen, DG Ellman, PM Madsen, JL Bixby, VP Lemmon, KL Lambertsen, R Brambilla
Cell Reports 2017
Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE): Inflammasomes in CNS Autoimmunity
W Barclay, ML Shinohara
Brain Pathology 2017
Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders
MD Ikonomovic, Z Mi, EE Abrahamson
Ageing Research Reviews 2017
A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS
L Bao, O Al-Assar, LF Drynan, MJ Arends, P Tyers, RA Barker, TH Rabbitts
Scientific Reports 2017
Vectorized nanodelivery systems for ischemic stroke: a concept and a need
AD Silva-Candal, B Argibay, R Iglesias-Rey, Z Vargas, A Vieites-Prado, E López-Arias, E Rodríguez-Castro, I López-Dequidt, M Rodríguez-Yáñez, Y Piñeiro, T Sobrino, F Campos, J Rivas, J Castillo
Journal of nanobiotechnology 2017
The Importance of VEGF-KDR Signaling Pathway Genes should Not Be Ignored When the Risk of Developing Multiple Sclerosis is Taken into Consideration
M Mazdeh, R Noroozi, J Gharesouran, A Sayad, A Komaki, MM Eftekharian, M Habibi, M Toghi, M Taheri
Journal of Molecular Neuroscience 2017
Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity
B Xu, Y Zhang, XF Du, J Li, HX Zi, JW Bu, Y Yan, H Han, JL Du
Cell Research 2017
Posterior reversible encephalopathy syndrome in a postpartum hemorrhagic woman without hypertension: A case report
CF Lio, YH Lee, HY Chan, CC Yu, NJ Peng, HP Chan
Medicine 2017
Chronic cocaine induces HIF-VEGF pathway activation along with angiogenesis in the brain
W Yin, K Clare, Q Zhang, ND Volkow, C Du, TV Arumugam
PloS one 2017
A Promising Approach to Integrally Evaluate the Disease Outcome of Cerebral Ischemic Rats Based on Multiple-Biomarker Crosstalk
G Ran, Y Wang, H Liu, C Wei, T Zhu, H Wang, H He, X Liu
Disease Markers 2017
Inflammation and vascular remodeling in the ventral hippocampus contributes to vulnerability to stress
J Pearson-Leary, D Eacret, R Chen, H Takano, B Nicholas, S Bhatnagar
Translational Psychiatry 2017
Transgenic expression of HuR increases vasogenic edema and impedes functional recovery in rodent ischemic stroke
AA Ardelt, RS Carpenter, I Iwuchukwu, A Zhang, W Lin, E Kosciuczuk, C Hinkson, T Rebeiz, S Reitz, PH King
Neuroscience Letters 2017
Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK
Y Jiang, X Lin, Z Tang, C Lee, G Tian, Y Du, X Yin, X Ren, L Huang, Z Ye, W Chen, F Zhang, J Mi, Z Gao, S Wang, Q Chen, L Xing, B Wang, Y Cao, WC Sessa, R Ju, Y Liu, X Li
Proceedings of the National Academy of Sciences 2017
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model
SA Berghoff, T Düking, L Spieth, J Winchenbach, SK Stumpf, N Gerndt, K Kusch, T Ruhwedel, W Möbius, G Saher
Acta Neuropathologica Communications 2017
Systemic Inflammation as a Driver of Brain Injury: the Astrocyte as an Emerging Player
B Bellaver, JP dos Santos, DT Leffa, LD Bobermin, PH Roppa, IL da Silva Torres, CA Gonçalves, DO Souza, A Quincozes-Santos
Molecular Neurobiology 2017
IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation
L Mayo, AP da Cunha, A Madi, V Beynon, Z Yang, JI Alvarez, A Prat, RA Sobel, L Kobzik, H Lassmann, FJ Quintana, HL Weiner
Brain 2016
A Review of the Mechanisms of Blood-Brain Barrier Permeability by Tissue-Type Plasminogen Activator Treatment for Cerebral Ischemia
Y Suzuki, N Nagai, K Umemura
Frontiers in cellular neuroscience 2016
Vascular endothelial growth factor: a neurovascular target in neurological diseases
C Lange, E Storkebaum, CR de Almodóvar, M Dewerchin, P Carmeliet
Nature Reviews Neurology 2016
Hydrogen Sulfide Attenuates Tissue Plasminogen Activator-Induced Cerebral Hemorrhage Following Experimental Stroke
H Liu, Y Wang, Y Xiao, Z Hua, J Cheng, J Jia
Translational Stroke Research 2016
Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes
L Huang, W Cao, Y Deng, G Zhu, Y Han, H Zeng
BMC neuroscience 2016
Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier
R Yang, W Liu, L Miao, X Yang, J Fu, B Dou, A Cai, X Zong, C Tan, H Chen, X Wang
Oncotarget 2016
Growth factor therapy sequesters inflammation in affording neuroprotection in cerebrovascular diseases
H Nguyen, D Aum, S Mashkouri, G Rao, JD Gonzales-Portillo, S Reyes, CV Borlongan
Expert Review of Neurotherapeutics 2016
Inhibition of Vascular Endothelial Growth Factor Receptor 2 Exacerbates Loss of Lower Motor Neurons and Axons during Experimental Autoimmune Encephalomyelitis
M Stanojlovic, X Pang, Y Lin, S Stone, M Cvetanovic, W Lin, RS Fujinami
PloS one 2016
Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse
Y Bai, Y Zhang, J Hua, X Yang, X Zhang, M Duan, X Zhu, W Huang, J Chao, R Zhou, G Hu, H Yao
Scientific Reports 2016
Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells
Y Wang, Y Cao, AK Mangalam, Y Guo, RG LaFrance-Corey, JD Gamez, PA Atanga, BD Clarkson, Y Zhang, E Wang, RS Angom, K Dutta, B Ji, I Pirko, CF Lucchinetti, CL Howe, D Mukhopadhyay
Journal of cell science 2016
Tight junction modulation of the blood brain barrier: CNS delivery of small molecules
C Greene, M Campbell
Tissue Barriers 2016
Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells
H Rosas-Hernandez, E Cuevas, SM Lantz, KC Rice, BM Gannon, WE Fantegrossi, C Gonzalez, MG Paule, SF Ali
Neuroscience Letters 2016
Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair
HS Domingues, CC Portugal, R Socodato, JB Relvas
Frontiers in Cell and Developmental Biology 2016
Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model
LJ Qin, YS Jia, YB Zhang, YH Wang
Biomedical Reports 2016
Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke
A Shindo, T Maki, ET Mandeville, AC Liang, N Egawa, K Itoh, N Itoh, M Borlongan, JC Holder, TT Chuang, JD McNeish, H Tomimoto, J Lok, EH Lo, K Arai
Stroke; a journal of cerebral circulation 2016
Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract
D Grundmann, M Klotz, H Rabe, M Glanemann, KH Schäfer
Scientific Reports 2015
Immune Quiescence of the Brain Is Set by Astroglial Connexin 43
AC Boulay, A Mazeraud, S Cisternino, B Saubamea, P Mailly, L Jourdren, C Blugeon, V Mignon, M Smirnova, A Cavallo, P Ezan, P Ave, F Dingli, D Loew, P Vieira, F Chretien, M Cohen-Salmon
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia
RA Radford, M Morsch, SL Rayner, NJ Cole, DL Pountney, RS Chung
Frontiers in cellular neuroscience 2015
Pericytes Contribute to the Disruption of the Cerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke
Y Bai, X Zhu, J Chao, Y Zhang, C Qian, P Li, D Liu, B Han, L Zhao, J Zhang, S Buch, G Teng, G Hu, H Yao, S Germain
PloS one 2015
Plasma Inflammatory Factors Are Associated with Anxiety, Depression, and Cognitive Problems in Adults with and without Methamphetamine Dependence: An Exploratory Protein Array Study
M Huckans, BE Fuller, AL Chalker, M Adams, JM Loftis
Frontiers in Psychiatry 2015
The Blood–Brain Barrier
R Daneman, A Prat
Cold Spring Harbor perspectives in biology 2015
Brain barriers: Crosstalk between complex tight junctions and adherens junctions
S Tietz, B Engelhardt
The Journal of Cell Biology 2015
Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions
C Chapouly, AT Argaw, S Horng, K Castro, J Zhang, L Asp, H Loo, BM Laitman, JN Mariani, RS Farber, E Zaslavsky, G Nudelman, CS Raine, GR John
Brain 2015
Group B Streptococcal Infection and Activation of Human Astrocytes
TD Stoner, TA Weston, JA Trejo, KS Doran, I Biswas
PloS one 2015
Preferential Recruitment of Neutrophils into the Cerebellum and Brainstem Contributes to the Atypical Experimental Autoimmune Encephalomyelitis Phenotype
Y Liu, AT Holdbrooks, GP Meares, JA Buckley, EN Benveniste, H Qin
Journal of immunology (Baltimore, Md. : 1950) 2015
Pathogenesis of Brain Edema and Investigation into Anti-Edema Drugs
S Michinaga, Y Koyama
International journal of molecular sciences 2015
Oligodendrocyte regeneration: its significance in myelin replacement and neuroprotection in multiple sclerosis
KA Chamberlain, SE Nanescu, K Psachoulia, JK Huang
Neuropharmacology 2015
Astrocyte barriers to neurotoxic inflammation
MV Sofroniew
Nature Reviews Neuroscience 2015
MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1
Y Li, L Mao, Y Gao, S Baral, Y Zhou, B Hu
Scientific Reports 2015
Glial regulation of the blood-brain barrier in health and disease
B Broux, E Gowing, A Prat
Seminars in Immunopathology 2015
The Sarcoglycan complex is expressed in the cerebrovascular system and is specifically regulated by astroglial Cx30 channels
AC Boulay, B Saubaméa, S Cisternino, V Mignon, Aà Mazeraud, L Jourdren, C Blugeon, M Cohen-Salmon
Frontiers in cellular neuroscience 2015
Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis
RD O'Shea, CL Lau, N Zulaziz, FL Maclean, DR Nisbet, MK Horne, PM Beart
Frontiers in neuroscience 2015
Protective effects of vascular endothelial growth factor in cultured brain endothelial cells against hypoglycemia
F Zhao, J Deng, X Yu, D Li, H Shi, Y Zhao
Metabolic Brain Disease 2015
Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling
A Haarmann, E Nowak, A Deiß, S der Pol, CM Monoranu, G Kooij, N Müller, P der Valk, G Stoll, HE de Vries, F Berberich-Siebelt, M Buttmann
Acta Neuropathologica 2015
Analysis of Chemokines and Receptors Expression Profile in the Myelin Mutant Taiep Rat
G Soto-Rodriguez, JA Gonzalez-Barrios, D Martinez-Fong, VM Blanco-Alvarez, JR Eguibar, A Ugarte, F Martinez-Perez, E Brambila, LM Peña, NG Pazos-Salazar, M Torres-Soto, G Garcia-Robles, C Tomas-Sanchez, BA Leon-Chavez
Oxidative medicine and cellular longevity 2015
The blood-brain barrier and methamphetamine: open sesame?
P Turowski, BA Kenny
Frontiers in neuroscience 2015
Pathogenesis of depression: Insights from human and rodent studies
C Ménard, GE Hodes, SJ Russo
Neuroscience 2015
Real-time estimation of paracellular permeability of cerebral endothelial cells by capacitance sensor array
DH Jo, R Lee, JH Kim, HO Jun, TG Lee, JH Kim
Scientific Reports 2015
Expression of Glucose Transporters in the Prelaminar Region of the Optic-Nerve Head of the Pig as Determined by Immunolabeling and Tissue Culture
FJ Carreras, CJ Aranda, D Porcel, F Rodriguez-Hurtado, O Martínez-Agustin, A Zarzuelo, T Chan-Ling
PloS one 2015
Anti-Vascular Endothelial Growth Factor Treatment Suppresses Early Brain Injury After Subarachnoid Hemorrhage in Mice
L Liu, M Fujimoto, F Kawakita, F Nakano, K Imanaka-Yoshida, T Yoshida, H Suzuki
Molecular Neurobiology 2015
Bevacizumab is safe in acute relapses of neuromyelitis optica
MA Mealy, K Shin, G John, M Levy
Clinical and Experimental Neuroimmunology 2015
The Role of Astrocytes in Multiple Sclerosis Progression
J Correale, MF Farez
Frontiers in neurology 2015
Mesenchymal stem cells stabilize the blood–brain barrier through regulation of astrocytes
HJ Park, JY Shin, HN Kim, SH Oh, SK Song, PH Lee
Stem Cell Research & Therapy 2015
Astrocyte roles in traumatic brain injury
JE Burda, AM Bernstein, MV Sofroniew
Experimental Neurology 2015
Astrocytes Regulate Angiogenesis Through the Jagged1-Mediated Notch1 Pathway After Status Epilepticus
X Zhai, P Liang, Y Li, L Li, Y Zhou, X Wu, J Deng, L Jiang
Molecular Neurobiology 2015
YAP Is a Critical Inducer of SOCS3, Preventing Reactive Astrogliosis
Z Huang, Y Wang, G Hu, J Zhou, L Mei, WC Xiong
Cerebral Cortex 2015
Improved Treatment Efficacy of Antiangiogenic Therapy when Combined with Picornavirus Vaccination in the GL261 Glioma Model
DN Renner, CS Malo, F Jin, IF Parney, KD Pavelko, AJ Johnson
Neurotherapeutics 2015
Astrocytes spatially restrict VEGF signaling by polarized secretion and incorporation of VEGF into the actively assembling extracellular matrix: Secretion and Function of VEGF in Astrocytes
K Egervari, G Potter, ML Guzman-Hernandez, P Salmon, M Soto-Ribeiro, B Kastberger, T Balla, B Wehrle-Haller, JZ Kiss
Glia 2015
Increased CSF biomarkers of angiogenesis in Parkinson disease
S Janelidze, D Lindqvist, V Francardo, S Hall, H Zetterberg, K Blennow, CH Adler, TG Beach, GE Serrano, D Westen, E Londos, MA Cenci, O Hansson
Neurology 2015
Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia: BBB cell-specific responses: health, disease and therapy
S Engelhardt, S Patkar, OO Ogunshola
British Journal of Pharmacology 2014
Temporal effects of vascular endothelial growth factor and 3,5-cyclic monophosphate on blood-brain barrier solute permeability in vivo: VEGF and cAMP Effects on BBB Permeability
L Shi, M Zeng, BM Fu
Journal of Neuroscience Research 2014
Role of Microglial M1/M2 Polarization in Relapse and Remission of Psychiatric Disorders and Diseases
Y Nakagawa, K Chiba
Pharmaceuticals (Basel, Switzerland) 2014
Reactive Gliosis and the Multicellular Response to CNS Damage and Disease
JE Burda, MV Sofroniew
Neuron 2014
Systemic and Cerebral Vascular Endothelial Growth Factor Levels Increase in Murine Cerebral Malaria along with Increased Calpain and Caspase Activity and Can be Reduced by Erythropoietin Treatment
C Hempel, N Hoyer, A Kildemoes, CB Jendresen, JÃ Kurtzhals
Frontiers in immunology 2014
Losartan prevents acquired epilepsy via TGF-β signaling suppression
G Bar-Klein, LP Cacheaux, L Kamintsky, O Prager, I Weissberg, K Schoknecht, P Cheng, SY Kim, L Wood, U Heinemann, D Kaufer, A Friedman
Annals of Neurology 2014
Sera from remitting and secondary progressive multiple sclerosis patients disrupt the blood-brain barrier
F Shimizu, A Tasaki, Y Sano, M Ju, H Nishihara, M Oishi, M Koga, M Kawai, T Kanda
PloS one 2014
Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration: TRPV1 and Astrocyte Migration
KW Ho, WS Lambert, DJ Calkins
Glia 2014
Neuronopathy in the Motor Neocortex in a Chronic Model of Multiple Sclerosis:
T Burns, L Miers, J Xu, A Man, M Moreno, D Pleasure, P Bannerman
Journal of Neuropathology and Experimental Neurology 2014
Differential apicobasal VEGF signaling at vascular blood-neural barriers
N Hudson, MB Powner, MH Sarker, T Burgoyne, M Campbell, ZK Ockrim, R Martinelli, CE Futter, MB Grant, PA Fraser, DT Shima, J Greenwood, P Turowski
Developmental Cell 2014
Amelioration of cold injury-induced cortical brain edema formation by selective endothelin ETB receptor antagonists in mice
S Michinaga, M Nagase, E Matsuyama, D Yamanaka, N Seno, M Fuka, Y Yamamoto, Y Koyama
PloS one 2014
Drowning stars: reassessing the role of astrocytes in brain edema
AS Thrane, VR Thrane, M Nedergaard
Trends in Neurosciences 2014
An in vitro blood-brain barrier model combining shear stress and endothelial cell/astrocyte co-culture
Y Takeshita, B Obermeier, A Cotleur, Y Sano, T Kanda, RM Ransohoff
Journal of Neuroscience Methods 2014
Blood-Brain Barrier Dysfunction and Cerebral Small Vessel Disease (Arteriolosclerosis) in Brains of Older People:
LR Bridges, J Andoh, AJ Lawrence, CH Khoong, WW Poon, MM Esiri, HS Markus, AH Hainsworth
Journal of Neuropathology and Experimental Neurology 2014
Brain Barriers and a Subpopulation of Astroglial Progenitors of Developing Human Forebrain Are Immunostained for the Glycoprotein YKL-40
C Bjornbak, CB Brochner, LA Larsen, JS Johansen, K Mollgard
Journal of Histochemistry & Cytochemistry 2014
Astrogliosis
MV Sofroniew
Cold Spring Harbor perspectives in biology 2014
Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis.
Girolamo F, Coppola C, Ribatti D, Trojano M
Acta Neuropathologica Communications 2014
Xiao-Xu-Ming Decoction Protects against Blood-Brain Barrier Disruption and Neurological Injury Induced by Cerebral Ischemia and Reperfusion in Rats
R Lan, J Xiang, GH Wang, WW Li, W Zhang, LL Xu, DF Cai
Evidence-Based Complementary and Alternative Medicine 2013
ALS and oxidative stress: the neurovascular scenario
A Anand, K Thakur, PK Gupta
Oxidative Medicine & Cellular Longevity 2013
VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration
P Carmeliet, CR de Almodovar
Cellular and Molecular Life Sciences 2013
Development, maintenance and disruption of the blood-brain barrier
B Obermeier, R Daneman, RM Ransohoff
Nature Medicine 2013
Venous endothelial injury in central nervous system diseases
JS Alexander, L Prouty, I Tsunoda, CV Ganta, A Minagar
BMC Medicine 2013
Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire
JO Watzlawik, B Wootla, MM Painter, AE Warrington, M Rodriguez
Expert Review of Neurotherapeutics 2013
Neurovascular abnormalities in brain disorders: highlights with angiogenesis and magnetic resonance imaging studies
CC Chen, YC Chen, HY Hsiao, C Chang, Y Chern
Journal of Biomedical Science 2013
Delineating multiple functions of VEGF-A in the adult brain
T Licht, E Keshet
Cellular and Molecular Life Sciences 2013
Astrocytes: Emerging stars in leukodystrophy pathogenesis
A Lanciotti, MS Brignone, E Bertini, TC Petrucci, F Aloisi, E Ambrosini
Translational Neuroscience 2013
Dose-dependent Neuroprotection of VEGF165 in Huntington’s Disease Striatum
SM Ellison, A Trabalza, V Tisato, E Pazarentzos, S Lee, V Papadaki, D Goniotaki, S Morgan, N Mirzaei, ND Mazarakis
Molecular Therapy 2013
Hypoxia-inducible factor 1 is essential for spontaneous recovery from traumatic brain injury and is a key mediator of heat acclimation induced neuroprotection
G Umschweif, AG Alexandrovich, V Trembovler, M Horowitz, E Shohami
Journal of Cerebral Blood Flow & Metabolism 2013
Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications
RJ Shannon, KL Carpenter, MR Guilfoyle, A Helmy, PJ Hutchinson
Journal of Pharmacokinetics and Pharmacodynamics 2013
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies
M Morin-Brureau, FD Bock, M Lerner-Natoli
Fluids and barriers of the CNS 2013
Innate immune responses to HIV infection in the central nervous system
R Geffin, M McCarthy
Immunologic Research 2013
Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression
YN Li, R Pan, XJ Qin, WL Yang, Z Qi, W Liu, KJ Liu
Journal of Neurochemistry 2013
Cellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons
J Lladó, L Tolosa, G Olmos
Frontiers in cellular neuroscience 2013
Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2
D Wiesner, I Merdian, J Lewerenz, AC Ludolph, L Dupuis, A Witting
PloS one 2013
Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes
YY Sun, SH Lin, HC Lin, CC Hung, CY Wang, YC Lin, KS Hung, CC Lien, CY Kuan, YH Lee
PloS one 2013
Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons
RD Spence, AJ Wisdom, Y Cao, HM Hill, CR Mongerson, B Stapornkul, N Itoh, MV Sofroniew, RR Voskuhl
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Glial influence on the blood brain barrier
JI Alvarez, T Katayama, A Prat
Glia 2013
Immune Players in the CNS: The Astrocyte
CJ Jensen, A Massie, JD Keyser
Journal of Neuroimmune Pharmacology 2013
Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases.
Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K
CNS & neurological disorders drug targets 2013
Characterization of the interaction between astrocytes and encephalitogenic lymphocytes during the development of experimental autoimmune encephalitomyelitis (EAE) in mice
JF Yang, HQ Tao, YM Liu, XX Zhan, Y Liu, XY Wang, JH Wang, LL Mu, LL Yang, ZM Gao, QF Kong, GY Wang, JH Han, B Sun, HL Li
Clinical & Experimental Immunology 2012
Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters
J Isung, S Aeinehband, F Mobarrez, B Mårtensson, P Nordström, M Asberg, F Piehl, J Jokinen
Translational Psychiatry 2012
Bone Marrow-derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic SCI
DM Norden, TD Faw, DB McKim, RJ Deibert, LC Fisher, JF Sheridan, JP Godbout, PT Ed.D.
Journal of Neurotrauma 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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