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Citations to this article

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
Theresa R. Bomfim, … , Sergio T. Ferreira, Fernanda G. De Felice
Theresa R. Bomfim, … , Sergio T. Ferreira, Fernanda G. De Felice
Published March 22, 2012
Citation Information: J Clin Invest. 2012;122(4):1339-1353. https://doi.org/10.1172/JCI57256.
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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

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Abstract

Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with Alzheimer’s disease (AD). Although a connection between AD and diabetes has been suggested, a major unknown is the mechanism(s) by which insulin resistance in the brain arises in individuals with AD. Here, we show that serine phosphorylation of IRS-1 (IRS-1pSer) is common to both diseases. Brain tissue from humans with AD had elevated levels of IRS-1pSer and activated JNK, analogous to what occurs in peripheral tissue in patients with diabetes. We found that amyloid-β peptide (Aβ) oligomers, synaptotoxins that accumulate in the brains of AD patients, activated the JNK/TNF-α pathway, induced IRS-1 phosphorylation at multiple serine residues, and inhibited physiological IRS-1pTyr in mature cultured hippocampal neurons. Impaired IRS-1 signaling was also present in the hippocampi of Tg mice with a brain condition that models AD. Importantly, intracerebroventricular injection of Aβ oligomers triggered hippocampal IRS-1pSer and JNK activation in cynomolgus monkeys. The oligomer-induced neuronal pathologies observed in vitro, including impaired axonal transport, were prevented by exposure to exendin-4 (exenatide), an anti-diabetes agent. In Tg mice, exendin-4 decreased levels of hippocampal IRS-1pSer and activated JNK and improved behavioral measures of cognition. By establishing molecular links between the dysregulated insulin signaling in AD and diabetes, our results open avenues for the investigation of new therapeutics in AD.

Authors

Theresa R. Bomfim, Leticia Forny-Germano, Luciana B. Sathler, Jordano Brito-Moreira, Jean-Christophe Houzel, Helena Decker, Michael A. Silverman, Hala Kazi, Helen M. Melo, Paula L. McClean, Christian Holscher, Steven E. Arnold, Konrad Talbot, William L. Klein, Douglas P. Munoz, Sergio T. Ferreira, Fernanda G. De Felice

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Yu L, Jin J, Xu Y, Zhu X
Journal of Translational Internal Medicine 2022
Docosahexaenoic acid enhances hippocampal insulin sensitivity to promote cognitive function of aged rats on a high-fat diet
Xu J, Ni B, Ma C, Rong S, Gao H, Zhang L, Xiang X, Huang Q, Deng Q, Huang F
Journal of Advanced Research 2022
Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics
Hunt NJ, Wahl D, Westwood LJ, Lockwood GP, Le Couteur DG, Cogger VC
Advanced Drug Delivery Reviews 2022
Alzheimer’s disease: a step closer to understanding type 3 diabetes in African Americans
SA Ferguson, JJ Panos, D Sloper, V Varma, S Sarkar
Metabolic Brain Disease 2021
Insulin action at a molecular level – 100 years of progress
MF White, CR Kahn
Molecular Metabolism 2021
Central Regulation of Metabolism by Growth Hormone
J Donato, F Wasinski, IC Furigo, M Metzger, R Frazão
Cells 2021
Regulation of Metabolic Health by an “Olfactory-Hypothalamic Axis” and Its Possible Implications for the Development of Therapeutic Approaches for Obesity and T2D
MA Guzmán-Ruiz, A Jiménez, A Cárdenas-Rivera, NN Guerrero-Vargas, D Organista-Juárez, R Guevara-Guzmán
Cellular and Molecular Neurobiology 2021
Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice
M Ettcheto, E Sánchez-Lopez, A Cano, M Carrasco, K Herrera, PR Manzine, T Espinosa-Jimenez, O Busquets, E Verdaguer, J Olloquequi, C Auladell, J Folch, A Camins
Cell & Bioscience 2021
Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease
AJ Yang, A Bagit, RE MacPherson
International journal of molecular sciences 2021
Diabetes and Alzheimer’s Disease: Might Mitochondrial Dysfunction Help Deciphering the Common Path?
MA Potenza, L Sgarra, V Desantis, C Nacci, M Montagnani
Antioxidants 2021
Metabolic Messengers: tumour necrosis factor
JK Sethi, GS Hotamisligil
2021
Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities
S SantaCruz-Calvo, L Bharath, G Pugh, L SantaCruz-Calvo, RR Lenin, J Lutshumba, R Liu, AD Bachstetter, B Zhu, BS Nikolajczyk
Nature Reviews Endocrinology 2021
Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia
S Uddin, M Rahman, MA Sufian, P Jeandet, GhulamAshraf, MN Bin-Jumah, SA Mousa, MM Abdel-Daim, MF Akhtar, A Saleem, S Amran
Frontiers in physiology 2021
Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration
Y Komleva, A Chernykh, O Lopatina, Y Gorina, I Lokteva, A Salmina, M Gollasch
Frontiers in neuroscience 2021
Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease
J Burillo, P Marqués, B Jiménez, C González-Blanco, M Benito, C Guillén
Cells 2021
The immune-opioid axis in prediabetes: predicting prediabetes with insulin resistance by plasma interleukin-10 and endomorphin-2 to kappa-opioid receptors ratio
SR Moustafa
Diabetology & metabolic syndrome 2021
Clusterin and Its Role in Insulin Resistance and the Cardiometabolic Syndrome
J Wittwer, D Bradley
Frontiers in immunology 2021
Intranasal insulin and orexins to treat age-related cognitive decline
JM Erichsen, CB Calva, LP Reagan, JR Fadel
Physiology & Behavior 2021
Proglucagon-Derived Peptides as Therapeutics
RA Lafferty, FP OHarte, N Irwin, VA Gault, PR Flatt
Frontiers in Endocrinology 2021
Reassessment of Pioglitazone for Alzheimer’s Disease
AM Saunders, DK Burns, WK Gottschalk
Frontiers in neuroscience 2021
Early Life Adversity and Polygenic Risk for High Fasting Insulin Are Associated With Childhood Impulsivity
A Batra, LM Chen, Z Wang, C Parent, I Pokhvisneva, S Patel, RD Levitan, MJ Meaney, PP Silveira
Frontiers in neuroscience 2021
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease
NM e Silva, RA Gonçalves, TA Pascoal, RA Lima-Filho, E de Paula França Resende, EL Vieira, AL Teixeira, LC de Souza, JA Peny, JT Fortuna, IC Furigo, D Hashiguchi, VS Miya-Coreixas, JR Clarke, JF Abisambra, BM Longo, J Donato, PE Fraser, P Rosa-Neto, P Caramelli, ST Ferreira, FG Felice
Translational Psychiatry 2021
Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer’s disease
M Zheng, P Wang
3 Biotech 2021
Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon‐like peptide‐1 receptor agonists
HN Yassine, V Solomon, A Thakral, N SheikhBahaei, HC Chui, MN Braskie, LS Schneider, K Talbot
Alzheimer's & dementia : the journal of the Alzheimer's Association 2021
Dysregulation of IGF-1/GLP-1 signaling in the progression of ALS: potential target activators and influences on neurological dysfunctions
A Shandilya, S Mehan
Neurological Sciences 2021
Association between exenatide use and incidence of Alzheimer's disease
B Zhou, J Zissimopoulos, H Nadeem, MA Crane, D Goldman, JA Romley
Alzheimer's & Dementia: Translational Research & Clinical Interventions 2021
Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer’s disease
T Ali, SU Rehman, A Khan, H Badshah, NB Abid, MW Kim, MH Jo, SS Chung, H Lee, BP Rutten, MO Kim
Molecular Neurodegeneration 2021
GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects
X Zhao, M Wang, Z Wen, Z Lu, L Cui, C Fu, H Xue, Y Liu, Y Zhang
Frontiers in Endocrinology 2021
Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model
LY Zhang, QQ Jin, C Hölscher, L Li
NEURAL REGEN RES 2021
Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment
SR Poor, M Ettcheto, A Cano, E Sanchez-Lopez, PR Manzine, J Olloquequi, A Camins, M Javan
Pharmaceuticals (Basel, Switzerland) 2021
Adiponectin improves amyloid‐β 31‐35‐induced circadian rhythm disorder in mice
Y Yuan, C Li, S Guo, C Sun, N Ning, H Hao, L Wang, Y Bian, H Liu, X Wang
Journal of Cellular and Molecular Medicine 2021
Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy
LP Reagan, HB Cowan, JL Woodruff, GG Piroli, JM Erichsen, AN Evans, HE Burzynski, ND Maxwell, FZ Loyo-Rosado, VA Macht, CA Grillo
Neurobiology of Stress 2021
Disruption of Glucose Metabolism in Aged Octodon degus: A Sporadic Model of Alzheimer's Disease
P Cisternas, C Gherardelli, P Salazar, NC Inestrosa
Frontiers in integrative neuroscience 2021
Brain Glucose Transporters: Role in Pathogenesis and Potential Targets for the Treatment of Alzheimer’s Disease
L Szablewski
International journal of molecular sciences 2021
Inflammasome NLRP3 Potentially Links Obesity-Associated Low-Grade Systemic Inflammation and Insulin Resistance with Alzheimer’s Disease
A Litwiniuk, W Bik, M Kalisz, A Baranowska-Bik
International journal of molecular sciences 2021
Oxidative Stress and Beta Amyloid in Alzheimer’s Disease. Which Comes First: The Chicken or the Egg?
E Tamagno, M Guglielmotto, V Vasciaveo, M Tabaton
Antioxidants 2021
The Impact of Differentiation on Cytotoxicity and Insulin Sensitivity in Streptozotocin Treated SH-SY5Y Cells
F Bagaméry, K Varga, K Kecsmár, I Vincze, É Szökő, T Tábi
Neurochemical Research 2021
Editorial: Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap!
M Dierssen, E Barone
Frontiers in neuroscience 2021
Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers
AF Batista, T Rody, L Forny-Germano, S Cerdeiro, M Bellio, ST Ferreira, DP Munoz, FG Felice
Journal of Neuroinflammation 2021
Enhancement of Insulin/PI3K/Akt Signaling Pathway and Modulation of Gut Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product, in Sporadic Alzheimer’s Disease Model in Mice
NS Sayed, EA Kandil, MH Ghoneum
Frontiers in pharmacology 2021
Targeting Common Signaling Pathways for the Treatment of Stroke and Alzheimer’s: a Comprehensive Review
S Eskandari, S Sajadimajd, L Alaei, Z Soheilikhah, H Derakhshankhah, G Bahrami
Neurotoxicity Research 2021
Metabolic Syndrome: Is It Time to Add the Central Nervous System?
M Rojas, M Chávez-Castillo, D Pirela, H Parra, M Nava, M Chacín, L Angarita, R Añez, J Salazar, R Ortiz, SD Agüero, M Gravini-Donado, V Bermúdez, E Díaz-Camargo
Nutrients 2021
Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases
JM Erichsen, JR Fadel, LP Reagan
Neuropharmacology 2021
Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease
S Austad, S Ballinger, T Buford, C Carter, D Smith, V Darley-Usmar, J Zhang
Acta pharmaceutica Sinica. B 2021
Advances in Genetics and Epigenetic Alterations in Alzheimer’s Disease: A Notion for Therapeutic Treatment
R Rabaneda-Bueno, B Mena-Montes, S Torres-Castro, N Torres-Carrillo, NM Torres-Carrillo
Genes & development 2021
Association of Alzheimer’s Disease and Insulin Resistance in King Abdulaziz Medical City, Jeddah
Faqih NT, Ashoor AF, Alshaikh SA, Maglan AF, Jastaniah N
Cureus 2021
In Vitro Comparative Study of Solid Lipid and PLGA Nanoparticles Designed to Facilitate Nose-to-Brain Delivery of Insulin
Akel H, Csóka I, Ambrus R, Bocsik A, Gróf I, Mészáros M, Szecskó A, Kozma G, Veszelka S, Deli MA, Kónya Z, Katona G
International journal of molecular sciences 2021
Liraglutide Reduces Vascular Damage, Neuronal Loss, and Cognitive Impairment in a Mixed Murine Model of Alzheimer’s Disease and Type 2 Diabetes
Carranza-Naval MJ, del Marco A, Hierro-Bujalance C, Alves-Martinez P, Infante-Garcia C, Vargas-Soria M, Herrera M, Barba-Cordoba B, Atienza-Navarro I, Lubian-Lopez S, Garcia-Alloza M
Frontiers in aging neuroscience 2021
Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal‐derived extracellular vesicles
Perluigi M, Picca A, Montanari E, Calvani R, Marini F, Matassa R, Tramutola A, Villani A, Familiari G, Domenico FD, Butterfield DA, Oh KJ, Marzetti E, Valentini D, Barone E
Alzheimer's and Dementia 2021
Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
AC Improta-Caria, CK Nonaka, BR Cavalcante, RA Sousa, RA Júnior, BS de Freitas Souza
International journal of molecular sciences 2020
Mini Review: Opposing Pathologies in Cancer and Alzheimer's Disease: Does the PI3K/Akt Pathway Provide Clues?
RM Barker, JM Holly, KM Biernacka, SJ Allen-Birt, CM Perks
Frontiers in Endocrinology 2020
Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer’s Disease: Targeting Mitochondria for Diagnosis and Prevention
Y Peng, P Gao, L Shi, L Chen, J Liu, J Long
Antioxidants & Redox Signaling 2020
Diabetes as a risk factor for Alzheimer’s disease in the Middle East and its shared pathological mediators
RL Jayaraj, S Azimullah, R Beiram
Saudi Journal of Biological Sciences 2020
A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy
K Gadhave, D Kumar, VN Uversky, R Giri
Medicinal Research Reviews 2020
Repositioning medication for cardiovascular and cerebrovascular disease to delay the onset and prevent progression of Alzheimer’s disease
H Lee, EY Kim
Archives of Pharmacal Research 2020

Liraglutide Attenuates Aβ42 Generation in APPswe/SH-SY5Y Cells Through the Regulation of Autophagy


J Kong, L Wan, Y Wang, H Zhang, W Zhang
Neuropsychiatric Disease and Treatment 2020
Alzheimer’s Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies
JC Shieh, PT Huang, YF Lin
Molecular Neurobiology 2020
Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology
A Koren-Iton, S Salomon-Zimri, A Smolar, E Shavit-Stein, A Dori, J Chapman, DM Michaelson
International journal of molecular sciences 2020
Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function
Z Arvanitakis, HY Wang, AW Capuano, A Khan, B Taïb, F AnokyeDanso, JA Schneider, DA Bennett, RS Ahima, SE Arnold
Annals of Neurology 2020
The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics
SA Kent, TL Spires-Jones, CS Durrant
Acta Neuropathologica 2020
Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer’s and Parkinson’s disease therapeutics
TS Salameh, EM Rhea, K Talbot, WA Banks
Biochemical Pharmacology 2020
Insulin resistance: a connecting link between Alzheimer’s disease and metabolic disorder
V Kshirsagar, C Thingore, A Juvekar
Metabolic Brain Disease 2020
Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain
JR Hahm, MH Jo, R Ullah, MW Kim, MO Kim
Cells 2020
MA-[D-Leu-4]-OB3, a small molecule synthetic peptide leptin mimetic, improves episodic memory, and reduces serum levels of tumor necrosis factor-alpha and neurodegeneration in mouse models of Type 1 and Type 2 Diabetes Mellitus
Z Hirschstein, GR Vanga, G Wang, ZM Novakovic, P Grasso
Biochimica et Biophysica Acta (BBA) - General Subjects 2020
Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review
J Berlanga-Acosta, G Guillén-Nieto, N Rodríguez-Rodríguez, ML Bringas-Vega, D García-del-Barco-Herrera, JO Berlanga-Saez, A García-Ojalvo, MJ Valdés-Sosa, PA Valdés-Sosa
Frontiers in Endocrinology 2020
Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer’s disease mouse model
RC Ng, M Jian, OK Ma, M Bunting, JS Kwan, GJ Zhou, K Senthilkumar, A Iyaswamy, PK Chan, M Li, KM Leung, SS Durairajan, KS Lam, LW Chu, R Festenstein, SK Chung, KH Chan
Molecular Psychiatry 2020
Clusterin as a Potential Biomarker of Obesity-Related Alzheimer’s Disease Risk
D Bradley
Biomarker insights 2020
Microglial Immunometabolism in Alzheimer’s Disease
DC Shippy, TK Ulland
Frontiers in cellular neuroscience 2020
Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions
M Dierssen, M Fructuoso, MM de Lagrán, M Perluigi, E Barone
Frontiers in neuroscience 2020
Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages
GD Stanciu, V Bild, DC Ababei, RN Rusu, A Cobzaru, L Paduraru, D Bulea
Journal of Clinical Medicine 2020
Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability?
M Waragai, G Ho, Y Takamatsu, R Wada, S Sugama, T Takenouchi, E Masliah, M Hashimoto
Frontiers in Endocrinology 2020
The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer’s Disease
M Maskery, EM Goulding, S Gengler, JU Melchiorsen, MM Rosenkilde, C Hölscher
American journal of Alzheimer's disease and other dementias 2020
Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease
TT Nguyen, QT Ta, TK Nguyen, TT Nguyen, VV Giau
International journal of molecular sciences 2020
Adipose Tissue and Brain Metabolic Responses to Western Diet—Is There a Similarity between the Two?
A Mazzoli, MS Spagnuolo, C Gatto, M Nazzaro, R Cancelliere, R Crescenzo, S Iossa, L Cigliano
International journal of molecular sciences 2020
Down’s syndrome and COVID-19: risk or protection factor against infection? A molecular and genetic approach
M Altable, JM de la Serna
Neurological Sciences 2020
GLP-1 receptor agonists for Parkinson's disease
CA Mulvaney, GS Duarte, J Handley, DJ Evans, S Menon, R Wyse, HC Emsley
Cochrane Database of Systematic Reviews 2020
Intranasal insulin administration may be highly effective in improving cognitive function in mice with cognitive dysfunction by reversing brain insulin resistance
H Lv, L Tang, C Guo, Y Jiang, C Gao, Y Wang, C Jian
Cognitive neurodynamics 2020
Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease
Y Sun, C Ma, H Sun, H Wang, W Peng, Z Zhou, H Wang, C Pi, Y Shi, X He
Journal of Diabetes Research 2020
β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology
DC Shippy, C Wilhelm, PA Viharkumar, TJ Raife, TK Ulland
Journal of Neuroinflammation 2020
Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link
A Brzecka, N Madetko, VN Nikolenko, GM Ashraf, M Ejma, J Leszek, C Daroszewski, K Sarul, LM Mikhaleva, SG Somasundaram, CE Kirkland, SO Bachurin, G Aliev
Current neuropharmacology 2020
Physical exercise protocols in animal models of Alzheimer’s disease: a systematic review
RA Sousa, CM Rodrigues, BF Mendes, AC Improta-Caria, MF Peixoto, RC Cassilhas
Metabolic Brain Disease 2020
Exploring the Therapeutic Potential of Protein Tyrosine Phosphatase 1B in hAPP-J20 Mouse Model of Alzheimer's Disease
J Ghalayini
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020
An update on potential links between type 2 diabetes mellitus and Alzheimer’s disease
RA Sousa, AR Harmer, DA Freitas, VA Mendonça, AC Lacerda, HR Leite
Molecular Biology Reports 2020
PKR: A Kinase to Remember
S Gal-Ben-Ari, I Barrera, M Ehrlich, K Rosenblum
Frontiers in molecular neuroscience 2019
Therapeutic Effects of Endogenous Incretin Hormones and Exogenous Incretin-Based Medications in Sepsis
FA Shah, H Mahmud, T Gallego-Martin, MJ Jurczak, CP ODonnell, BJ McVerry
The Journal of clinical endocrinology and metabolism 2019
Hypothesis and Theory: Circulating Alzheimer's-Related Biomarkers in Type 2 Diabetes. Insight From the Goto-Kakizaki Rat
J Movassat, E Delangre, J Liu, YC Gu, N Janel
Frontiers in neurology 2019
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD
W Wang, D Tanokashira, Y Fukui, M Maruyama, C Kuroiwa, T Saito, TC Saido, A Taguchi
Nutrients 2019
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
MV Lourenco, RL Frozza, GB de Freitas, H Zhang, GC Kincheski, FC Ribeiro, RA Gonçalves, JR Clarke, D Beckman, A Staniszewski, H Berman, LA Guerra, L Forny-Germano, S Meier, DM Wilcock, JM de Souza, S Alves-Leon, VF Prado, MA Prado, JF Abisambra, F Tovar-Moll, P Mattos, O Arancio, ST Ferreira, FG Felice
Nature Medicine 2019
Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes
N de M. Lyra e Silva, MP Lam, CN Soares, DP Munoz, R Milev, FG Felice
Frontiers in Psychiatry 2019
The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s Disease
L Forny-Germano, FG Felice, MN do Nascimento Vieira
Frontiers in neuroscience 2019
Involvement of insulin receptor substrates in cognitive impairment and Alzheimer’s disease
D Tanokashira, W Fukuokaya, A Taguchi
NEURAL REGEN RES 2019
Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting
Y Zhang, JZ Xie, XY Xu, J Hu, T Xu, S Jin, SJ Yang, JZ Wang
Neuroscience Bulletin 2019
Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer
MM Koseoglu, A Norambuena, ER Sharlow, JS Lazo, GS Bloom, HU Demuth
Journal of Alzheimer's disease : JAD 2019
Broadening the definition of brain insulin resistance in aging and Alzheimer's disease
HN Frazier, AO Ghoweri, KL Anderson, RL Lin, NM Porter, O Thibault
Experimental Neurology 2019
Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease: A Secondary Analysis of the Exenatide-PD Trial
D Athauda, S Gulyani, H Karnati, Y Li, D Tweedie, M Mustapic, S Chawla, K Chowdhury, SS Skene, NH Greig, D Kapogiannis, T Foltynie
JAMA NEUROL 2019
The Link Between Tau and Insulin Signaling: Implications for Alzheimer’s Disease and Other Tauopathies
RA Gonçalves, N Wijesekara, PE Fraser, FG Felice
Frontiers in cellular neuroscience 2019
Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer’s Disease
R Li, Y Zhang, S Rasool, T Geetha, JR Babu
Oxidative medicine and cellular longevity 2019
Extracellular Vesicle Biomarkers Track Cognitive Changes Following Intranasal Insulin in Alzheimer’s Disease
M Mustapic, J Tran, S Craft, D Kapogiannis, M Mulder
Journal of Alzheimer's disease : JAD 2019
Potential preventive disease-modifying pharmacological strategies to delay late onset Alzheimer's disease
M Ettcheto, O Busquets, A Camins
NEURAL REGEN RES 2019
Green Tea Seed Oil Suppressed Aβ1–42-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway
Kim, Park, Kang, Park, Yoo, Han, Cho, Kim, Heo
International journal of molecular sciences 2019
Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer’s Disease
C Hölscher
Frontiers in aging neuroscience 2019
A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions
SA Dass, K McCracken, I Pokhvisneva, LM Chen, E Garg, TT Nguyen, Z Wang, B Barth, M Yaqubi, LM McEwen, JL MacIsaac, J Diorio, MS Kobor, KJ O'Donnell, MJ Meaney, PP Silveira
EBioMedicine 2019
Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease
T Wakabayashi, K Yamaguchi, K Matsui, T Sano, T Kubota, T Hashimoto, A Mano, K Yamada, Y Matsuo, N Kubota, T Kadowaki, T Iwatsubo
Molecular Neurodegeneration 2019
Late Cognitive Consequences of Gestational Diabetes to the Offspring, in a New Mouse Model
RA de Sousa, EV de Lima, TP da Silva, RV de Souza, CP Figueiredo, GF Passos, JR Clarke
Molecular Neurobiology 2019
Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer’s disease by restoring microglial function via a PPAR-γ-dependent mechanism
E Medrano-Jiménez, IJ Carrillo, M Pedraza-Escalona, CE Ramírez-Serrano, L Álvarez-Arellano, J Cortés-Mendoza, M Herrera-Ruiz, E Jiménez-Ferrer, A Zamilpa, J Tortoriello, G Pedraza-Alva, L Pérez-Martínez
Journal of Neuroinflammation 2019
Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway
S Gabbouj, S Ryhänen, M Marttinen, R Wittrahm, M Takalo, S Kemppainen, H Martiskainen, H Tanila, A Haapasalo, M Hiltunen, T Natunen
Frontiers in neuroscience 2019
Precision Aging: Applying Precision Medicine to the Field of Cognitive Aging
L Ryan, M Hay, MJ Huentelman, A Duarte, T Rundek, B Levin, A Soldan, C Pettigrew, MR Mehl, CA Barnes
Frontiers in aging neuroscience 2019
Consequences of Metabolic Disruption in Alzheimer’s Disease Pathology
JC Ryu, ER Zimmer, P Rosa-Neto, SO Yoon
Neurotherapeutics 2019
Circulating IGFBP‐2: a novel biomarker for incident dementia
ER McGrath, JJ Himali, D Levy, SC Conner, CS DeCarli, MP Pase, P Courchesne, CL Satizabal, RS Vasan, AS Beiser, S Seshadri
Annals of Clinical and Translational Neurology 2019
Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases
M Grieco, A Giorgi, MC Gentile, M dErme, S Morano, B Maras, T Filardi
Frontiers in neuroscience 2019
A Pilot Study of Exenatide Actions in Alzheimer’s Disease
RJ Mullins, M Mustapic, CW Chia, O Carlson, S Gulyani, J Tran, Y Li, MP Mattson, S Resnick, JM Egan, NH Greig, D Kapogiannis
Current Alzheimer research 2019
Dementia risk by combinations of metabolic diseases and body mass index: Japan Gerontological Evaluation Study Cohort Study
H Yokomichi, K Kondo, Y Nagamine, Z Yamagata, N Kondo
Journal of Diabetes Investigation 2019
Retinal Microperimetry: A Useful Tool for Detecting Insulin Resistance-Related Cognitive Impairment in Morbid Obesity
A Ciudin, A Ortiz, E Fidilio, D Romero, M Sánchez, M Comas, O Gonzalez, R Vilallonga, O Simó-Servat, C Hernández, R Simó
Journal of Clinical Medicine 2019
Antidiabetic therapies and Alzheimer disease
Bendlin BB
Dialogues in clinical neuroscience 2019
基于神经网络芯片的阿尔茨海默病体外病理模型及其实时动态分析
2019
Insulin Resistance in Alzheimer's Disease
LS Ferreira, CS Fernandes, MN Vieira, FG Felice
Frontiers in neuroscience 2018
Nutrients and Oxidative Stress: Friend or Foe?
BL Tan, ME Norhaizan, WP Liew
Oxidative medicine and cellular longevity 2018
Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease
SK Rad, A Arya, H Karimian, P Madhavan, F Rizwan, S Koshy, G Prabhu
Drug design, development and therapy 2018
The Therapeutic Potential of Metformin in Neurodegenerative Diseases
C Rotermund, G Machetanz, JC Fitzgerald
Frontiers in Endocrinology 2018
Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches
R Hussain, H Zubair, S Pursell, M Shahab
Brain Sciences 2018
Dietary influences on cognition
AC Reichelt, LE Stoeckel, LP Reagan, CA Winstanley, KA Page
Physiology & Behavior 2018
The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade
EN Cline, MA Bicca, KL Viola, WL Klein, G Perry, J Avila, PI Moreira, AA Sorensen, M Tabaton
Journal of Alzheimer's disease : JAD 2018
Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism
P Vercruysse, D Vieau, D Blum, Å Petersén, L Dupuis
Frontiers in molecular neuroscience 2018
Metformin treatment ameliorates diabetes-associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1
D Tanokashira, E Kurata, W Fukuokaya, K Kawabe, M Kashiwada, H Takeuchi, M Nakazato, A Taguchi
FEBS Open Bio 2018
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
SE Arnold, Z Arvanitakis, SL Macauley-Rambach, AM Koenig, HY Wang, RS Ahima, S Craft, S Gandy, C Buettner, LE Stoeckel, DM Holtzman, DM Nathan
Nature Reviews Neurology 2018
Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition
P Denver, PL McClean
NEURAL REGEN RES 2018
Microvascular insulin resistance in skeletal muscle and brain occurs early in the development of juvenile obesity in pigs
TD Olver, ZI Grunewald, TJ Jurrissen, RE MacPherson, PJ LeBlanc, TR Schnurbusch, AM Czajkowski, MH Laughlin, RS Rector, SB Bender, EM Walters, CA Emter, J Padilla
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2018
O-GlcNAc cycling in the developing, adult and geriatric brain
O Lagerlöf
Journal of Bioenergetics and Biomembranes 2018
Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases: Newer rationales for anti-TNF therapy of neurodegenerative diseases
IA Clark, B Vissel
British Journal of Pharmacology 2018
The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease: Liraglutide protects memory, insulin receptors, and synapses
AF Batista, L Forny-Germano, JR Clarke, NM e Silva, J Brito-Moreira, SE Boehnke, A Winterborn, BC Coe, A Lablans, JF Vital, SA Marques, AM Martinez, M Gralle, C Holscher, WL Klein, JC Houzel, ST Ferreira, DP Munoz, FG Felice
The Journal of Pathology 2018
Sweet Mitochondria: A Shortcut to Alzheimer’s Disease
PI Moreira, G Perry, J Avila, M Tabaton, X Zhu
Journal of Alzheimer's disease : JAD 2018
Glutamine Synthetase: Localization Dictates Outcome
A Castegna, A Menga
Genes & development 2018
Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
RL Frozza, MV Lourenco, FG Felice
Frontiers in neuroscience 2018
Suppressor of Cytokine Signaling 3: Emerging Role Linking Central Insulin Resistance and Alzheimer’s Disease
L Cao, Z Wang, W Wan
Frontiers in neuroscience 2018
New views and possibilities of antidiabetic drugs in treating and/or preventing mild cognitive impairment and Alzheimer’s Disease
KL Zhong, F Chen, H Hong, X Ke, YG Lv, SS Tang, YB Zhu
Metabolic Brain Disease 2018
Magnetic resonance spectroscopy reveals abnormalities of glucose metabolism in the Alzheimer's brain
R Mullins, D Reiter, D Kapogiannis
Annals of Clinical and Translational Neurology 2018
miR-129 controls axonal regeneration via regulating insulin-like growth factor-1 in peripheral nerve injury
H Zhu, C Xue, M Yao, H Wang, P Zhang, T Qian, S Zhou, S Li, B Yu, Y Wang, X Gu
Cell Death and Disease 2018
Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review
C Benedict, CA Grillo
Frontiers in neuroscience 2018
Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease
E Barone, A Tramutola, F Triani, S Calcagnini, FD Domenico, C Ripoli, S Gaetani, C Grassi, DA Butterfield, T Cassano, M Perluigi
Molecular Neurobiology 2018
GLP-1 Receptor Agonist Exendin-4 Attenuates NR4A Orphan Nuclear Receptor NOR1 Expression in Vascular Smooth Muscle Cells
H Takahashi, T Nomiyama, Y Terawaki, T Kawanami, Y Hamaguchi, T Tanaka, M Tanabe, D Bruemmer, T Yanase
Journal of Atherosclerosis and Thrombosis 2018
Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer’s Disease Pathology and Shows Differential Expression in Transgenic Mice
LW Bonham, EG Geier, NZ Steele, D Holland, BL Miller, AM Dale, RS Desikan, JS Yokoyama
Frontiers in neuroscience 2018
Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models
S Higaki, M Muramatsu, A Matsuda, K Matsumoto, J Satoh, M Michikawa, S Niida, G Pignataro
PloS one 2018
Differential Binding of Human ApoE Isoforms to Insulin Receptor is Associated with Aberrant Insulin Signaling in AD Brain Samples
ES Chan, C Chen, TW Soong, BS Wong
NeuroMolecular Medicine 2018
The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS1 Activation
V Sposato, N Canu, E Fico, S Fusco, G Bolasco, MT Ciotti, M Spinelli, D Mercanti, C Grassi, V Triaca, P Calissano
Molecular Neurobiology 2018
Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis
GS Bloom, JS Lazo, A Norambuena
Neuropharmacology 2018
Pathophysiological abnormalities in the brains of Spontaneous Diabetes Torii-Lepr fa (SDT fatty) rats, a novel type 2 diabetic model
T MAEKAWA, T OHTA, S KUME
Journal of Veterinary Medical Science 2018
Amelioration of Aluminum Maltolate-Induced Inflammation and Endoplasmic Reticulum Stress-Mediated Apoptosis by Tannoid Principles of Emblica officinalis in Neuronal Cellular Model
MD Bharathi, A Justin-Thenmozhi, T Manivasagam, MA Rather, CS Babu, MM Essa, GJ Guillemin
Neurotoxicity Research 2018
Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications
A Tumminia, F Vinciguerra, M Parisi, L Frittitta
International journal of molecular sciences 2018
Possible Clues for Brain Energy Translation via Endolysosomal Trafficking of APP-CTFs in Alzheimer’s Disease
S Sivanesan, R Mundugaru, J Rajadas
Oxidative medicine and cellular longevity 2018
Influence of High-Fat Diets Consumed During the Juvenile Period on Hippocampal Morphology and Function
ND Olmo, M Ruiz-Gayo
Frontiers in cellular neuroscience 2018
The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease
X Zhang, Z Fu, L Meng, M He, Z Zhang
Frontiers in aging neuroscience 2018
The Role of Long Noncoding RNAs in Diabetic Alzheimer’s Disease
YK Kim, J Song
Journal of Clinical Medicine 2018
Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis
KM Andersson, C Wasén, L Juzokaite, L Leifsdottir, MC Erlandsson, ST Silfverswärd, A Stokowska, M Pekna, M Pekny, K Olmarker, RA Heckemann, M Kalm, MI Bokarewa
Proceedings of the National Academy of Sciences 2018
Could α-Synuclein Modulation of Insulin and Dopamine Identify a Novel Link Between Parkinson’s Disease and Diabetes as Well as Potential Therapies?
G Vidal-Martinez, B Yang, J Vargas-Medrano, RG Perez
Frontiers in molecular neuroscience 2018
Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer’s and Parkinson’s Diseases
AF Batista, V Bodart-Santos, FG Felice, ST Ferreira
CNS Drugs 2018
Moving towards a more realistic concept of what constitutes Alzheimer's disease
C Hölscher
EBioMedicine 2018
Effective nose-to-brain delivery of exendin-4 via coadministration with cell-penetrating peptides for improving progressive cognitive dysfunction
N Kamei, N Okada, T Ikeda, H Choi, Y Fujiwara, H Okumura, M Takeda-Morishita
Scientific Reports 2018
Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism
HA Ferris, RJ Perry, GV Moreira, GI Shulman, JD Horton, CR Kahn
Proceedings of the National Academy of Sciences 2017
Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
N Zhao, CC Liu, AJ van Ingelgom, YA Martens, C Linares, JA Knight, MM Painter, PM Sullivan, G Bu
Neuron 2017
Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin
CD de Filho, L Kappeler, J Dupont, J Solinc, S Villapol, C Denis, M Nosten-Bertrand, JM Billard, A Blaise, F Tronche, B Giros, C Charriaut-Marlangue, S Aïd, YL Bouc, M Holzenberger
Journal of Cerebral Blood Flow & Metabolism 2017
Curcumin regulates insulin pathways and glucose metabolism in the brains of APPswe/PS1dE9 mice
P Wang, C Su, H Feng, X Chen, Y Dong, Y Rao, Y Ren, J Yang, J Shi, J Tian, S Jiang
International journal of immunopathology and pharmacology 2017
Type 2 diabetes mellitus in the pathophysiology of Alzheimer's disease
AM de Nazareth
Dementia & Neuropsychologia 2017
Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?
MN Vieira, NM Silva, ST Ferreira, FG de Felice
Frontiers in aging neuroscience 2017
Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease: Brain IR and AD Atrophy
RJ Mullins, M Mustapic, EJ Goetzl, D Kapogiannis
Human Brain Mapping 2017
mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease
A Norambuena, H Wallrabe, L McMahon, A Silva, E Swanson, SS Khan, D Baerthlein, E Kodis, S Oddo, JW Mandell, GS Bloom
Alzheimer's and Dementia 2017
Recent Progress in Alzheimer’s Disease Research, Part 2: Genetics and Epidemiology
M Robinson, BY Lee, FT Hane
Journal of Alzheimer's disease : JAD 2017
Insulin resistance and exendin-4 treatment for multiple system atrophy
F Bassil, MH Canron, A Vital, E Bezard, Y Li, NH Greig, S Gulyani, D Kapogiannis, PO Fernagut, WG Meissner
Brain 2017
Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer’s disease
A Kaminari, N Giannakas, A Tzinia, EC Tsilibary
Scientific Reports 2017
Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice
S Chen, J Sun, G Zhao, A Guo, Y Chen, R Fu, Y Deng
Neurochemical Research 2017
Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease
RJ Mullins, TC Diehl, CW Chia, D Kapogiannis
Frontiers in aging neuroscience 2017
Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice
J Brito-Moreira, MV Lourenco, MM Oliveira, FC Ribeiro, JH Ledo, LP Diniz, JF Vital, MH Magdesian, HM Melo, F Barros-Aragão, JM de Souza, SV Alves-Leon, FC Gomes, JR Clarke, CP Figueiredo, FG de Felice, ST Ferreira
The Journal of biological chemistry 2017
Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons
GS da Silva, HM Melo, MV Lourenco, NM Silva, MB de Carvalho, SV Alves-Leon, JM de Souza, WL Klein, WS da-Silva, ST Ferreira, FG de Felice
The Journal of biological chemistry 2017
Endoplasmic reticulum stress and inflammation in the central nervous system
NT Sprenkle, SG Sims, CL Sánchez, GP Meares
Molecular Neurodegeneration 2017
Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats
E Candeias, I Sebastião, S Cardoso, C Carvalho, MS Santos, CR Oliveira, PI Moreira, AI Duarte
Molecular Neurobiology 2017
Tau deletion promotes brain insulin resistance
E Marciniak, A Leboucher, E Caron, T Ahmed, A Tailleux, J Dumont, T Issad, E Gerhardt, P Pagesy, M Vileno, C Bournonville, M Hamdane, K Bantubungi, S Lancel, D Demeyer, S Eddarkaoui, E Vallez, D Vieau, S Humez, E Faivre, B Grenier-Boley, TF Outeiro, B Staels, P Amouyel, D Balschun, L Buee, D Blum
Journal of Experimental Medicine 2017
Regulation of brain insulin signaling: A new function for tau
M Gratuze, E Planel
Journal of Experimental Medicine 2017
Reduction of Cognitive Decline in Patients with or at High Risk for Diabetes
GE Maestre
Current Geriatrics Reports 2017
Oxidative toxicity in diabetes and Alzheimer’s disease: mechanisms behind ROS/ RNS generation
W Ahmad, B Ijaz, K Shabbiri, F Ahmed, S Rehman
Journal of Biomedical Science 2017
Inhibition of Inflammation Mediated Through the Tumor Necrosis Factor α Biochemical Pathway Can Lead to Favorable Outcomes in Alzheimer Disease
D Shamim, M Laskowski
Journal of Central Nervous System Disease 2017
Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers
J Pitt, KC Wilcox, V Tortelli, LP Diniz, MS Oliveira, C Dobbins, XW Yu, S Nandamuri, FC Gomes, N DiNunno, KL Viola, FG de Felice, ST Ferreira, WL Klein, RG Parton
Molecular biology of the cell 2017
Calcium Dysregulation in Alzheimer's Disease: A Target for New Drug Development
Y Wang, Y Shi, H Wei
Journal of Alzheimer’s Disease & Parkinsonism 2017
Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis
Q Pan, X Li, Y Liu, F Wang, Y Hou, Q Bian, W Qiu, Z Yan, Y Jiang, J Chen
Neural plasticity 2017
Training Microglia to Resist Alzheimer's Disease
MN Vieira, D Beckman
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
Glucagon-Like Peptide-1 (GLP-1) Treatment Ameliorates Cognitive Impairment by Attenuating Arc Expression in Type 2 Diabetic Rats.
Cai XS, Tan ZG, Li JJ, Gao WH, Li SJ, Li JL, Tang YM, Li HW, Hui HX
Medical science monitor : international medical journal of experimental and clinical research 2017
Intranasal insulin in Alzheimer’s disease: Food for thought
Chapman CD, Schiöth HB, Grillo CA, Benedict C
Neuropharmacology 2017
Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-  Oligomers in Mice
JH Ledo, EP Azevedo, D Beckman, FC Ribeiro, LE Santos, DS Razolli, GC Kincheski, HM Melo, M Bellio, AL Teixeira, LA Velloso, D Foguel, FG de Felice, ST Ferreira
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
E Barini, O Antico, Y Zhao, F Asta, V Tucci, T Catelani, R Marotta, H Xu, L Gasparini
Molecular Neurodegeneration 2016
Lipid microdomain modification sustains neuronal viability in models of Alzheimer’s disease
S Herzer, S Meldner, K Rehder, HJ Gröne, V Nordström
Acta Neuropathologica Communications 2016
Neuroenergetics of traumatic brain injury
K Karelina, ZM Weil
Concussion 2016
IRS proteins and diabetic complications
DP Lavin, MF White, DP Brazil
Diabetologia 2016
The Rationale for Insulin Therapy in Alzheimer’s Disease
S Ribarič
Molecules (Basel, Switzerland) 2016
Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells
D Najem, M Bamji-Mirza, Z Yang, W Zhang
Neuroscience Bulletin 2016
Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model
C Guo, S Zhang, JY Li, C Ding, ZH Yang, R Chai, X Wang, ZY Wang
Scientific Reports 2016
Exercise for the diabetic brain: how physical training may help prevent dementia and Alzheimer’s disease in T2DM patients
S Bertram, K Brixius, C Brinkmann
Endocrine 2016
The rise and fall of insulin signaling in Alzheimer’s disease
B Chami, AJ Steel, SM de la Monte, GT Sutherland
Metabolic Brain Disease 2016
Cytokines and Cytokine Receptors Involved in the Pathogenesis of Alzheimers Disease
T Nagae, K Araki
Journal of Clinical & Cellular Immunology 2016
Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson’s Disease
J Song, J Kim
Frontiers in aging neuroscience 2016
Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits
JR Fadel, LP Reagan
Current Opinion in Behavioral Sciences 2016
Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders
Q Meng, Z Ying, E Noble, Y Zhao, R Agrawal, A Mikhail, Y Zhuang, E Tyagi, Q Zhang, JH Lee, M Morselli, L Orozco, W Guo, TM Kilts, J Zhu, B Zhang, M Pellegrini, X Xiao, MF Young, F Gomez-Pinilla, X Yang
EBioMedicine 2016
Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
SH Lee, JM Zabolotny, H Huang, H Lee, YB Kim
Molecular Metabolism 2016
Can physical exercise in old age improve memory and hippocampal function?
E Duzel, H Praag, M Sendtner
Brain 2016
Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal
R Kandimalla, V Thirumala, PH Reddy
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016
In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial
M Gejl, A Gjedde, L Egefjord, A Møller, SB Hansen, K Vang, A Rodell, H Brændgaard, H Gottrup, A Schacht, N Møller, B Brock, J Rungby
Frontiers in aging neuroscience 2016
Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?
M Stanley, SL Macauley, DM Holtzman
Journal of Experimental Medicine 2016
Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology
EL Abner, PT Nelson, RJ Kryscio, FA Schmitt, DW Fardo, RL Woltjer, NJ Cairns, L Yu, HH Dodge, C Xiong, K Masaki, SL Tyas, DA Bennett, JA Schneider, Z Arvanitakis
Alzheimer's and Dementia 2016
Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice
YF Mao, Z Guo, T Zheng, Y Jiang, Y Yan, X Yin, Y Chen, B Zhang
Aging Cell 2016
Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease
HH Hansen, K Fabricius, P Barkholt, P Kongsbak-Wismann, C Schlumberger, J Jelsing, D Terwel, A Termont, C Pyke, LB Knudsen, N Vrang, J Padmanabhan
PloS one 2016
Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling
A Kleinridders
Journal of Neuroendocrinology 2016
Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice
RC Ng, OY Cheng, M Jian, JS Kwan, PW Ho, KK Cheng, PK Yeung, LL Zhou, RL Hoo, SK Chung, A Xu, KS Lam, KH Chan
Molecular Neurodegeneration 2016
Insulin resistance in Alzheimer's disease
T Diehl, R Mullins, D Kapogiannis
Translational Research 2016
The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice
M Stanley, SL Macauley, EE Caesar, LJ Koscal, W Moritz, GO Robinson, J Roh, J Keyser, H Jiang, DM Holtzman
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice
FS Neves, PT Marques, F BarrosAragão, JB Nunes, AM Venancio, D Cozachenco, RL Frozza, GF Passos, R Costa, J de Oliveira, DF Engel, AF Bem, CF Benjamim, FG Felice, ST Ferreira, JR Clarke, CP Figueiredo
Molecular Neurobiology 2016
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
A Kleinridders, W Cai, L Cappellucci, A Ghazarian, WR Collins, SG Vienberg, EN Pothos, CR Kahn
Proceedings of the National Academy of Sciences 2015
Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal
Rajat Sandhir, Smriti Gupta
World journal of diabetes 2015
Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease
ST Ferreira, MV Lourenco, MM Oliveira, FG de Felice
Frontiers in cellular neuroscience 2015
Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer’s Disease: Impacts on Cognitive Decline
J Walker, F Harrison
Nutrients 2015
Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation
JR Clarke, NM Silva, CP Figueiredo, RL Frozza, JH Ledo, D Beckman, CK Katashima, D Razolli, BM Carvalho, R Frazao, MA Silveira, FC Ribeiro, TR Bomfim, FS Neves, WL Klein, R Medeiros, FM LaFerla, JB Carvalheira, MJ Saad, DP Munoz, LA Velloso, ST Ferreira, FG de Felice
EMBO Molecular Medicine 2015
Minireview: Food for Thought: Regulation of Synaptic Function by Metabolic Hormones
G McGregor, Y Malekizadeh, J Harvey
Molecular Endocrinology 2015
Endoplasmic Reticulum Stress Impairs Insulin Receptor Signaling in the Brains of Obese Rats
L Liang, J Chen, L Zhan, X Lu, X Sun, H Sui, L Zheng, H Xiang, F Zhang, C Scavone
PloS one 2015
Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis
KL Viola, WL Klein
Acta Neuropathologica 2015
Diabetes Mellitus Accelerates Aβ Pathology in Brain Accompanied by Enhanced GAβ Generation in Nonhuman Primates
S Okabayashi, N Shimozawa, Y Yasutomi, K Yanagisawa, N Kimura, Y Nagai
PloS one 2015
Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment
X Li, S Leng, D Song
Clinical Interventions in Aging 2015
Diabetes Mellitus, Cognitive Impairment, and Traditional Chinese Medicine
SW Seto, GY Yang, H Kiat, A Bensoussan, YW Kwan, D Chang
International Journal of Endocrinology 2015
Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis
J Pedroso, T Zampieri, J Donato
Nutrients 2015
Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease
FG de Felice, MV Lourenco
Frontiers in aging neuroscience 2015
Aberrant insulin signaling in Alzheimer's disease: current knowledge
G Bedse, FD Domenico, G Serviddio, T Cassano
Frontiers in neuroscience 2015
Neurotrophic and neuroprotective properties of exendin-4 in adult rat dorsal root ganglion neurons: involvement of insulin and RhoA
M Tsukamoto, N Niimi, K Sango, S Takaku, Y Kanazawa, K Utsunomiya
Histochemistry and Cell Biology 2015
Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model
N Kunath, T Groen, DB Allison, A Kumar, M Dozier-Sharpe, I Kadish
Scientific Reports 2015
The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer’s Disease
HH Hansen, K Fabricius, P Barkholt, ML Niehoff, JE Morley, J Jelsing, C Pyke, LB Knudsen, SA Farr, N Vrang
Journal of Alzheimer's disease : JAD 2015
Glucagon peptide-like 1 receptor (GLP-1R) expression per se: a new insight into neurodegenerative disease?
S Park, D Kim
NEURAL REGEN RES 2015
Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation
Y Gong, Y Ma, M Sinyuk, S Loganathan, RC Thompson, JN Sarkaria, W Chen, JD Lathia, BC Mobley, SW Clark, J Wang
Neuro-Oncology 2015
The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain–cerebellar interactions
C Weiss, JF Disterhoft
Behavioral Neuroscience 2015
Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide
EM Candeias
World journal of diabetes 2015
Linking insulin with Alzheimer’s disease: emergence as type III diabetes
S Ahmed, Z Mahmood, S Zahid
Neurological Sciences 2015
Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance
P Cisternas, P Salazar, FG Serrano, C Montecinos-Oliva, SB Arredondo, L Varela-Nallar, S Barja, CP Vio, F Gomez-Pinilla, NC Inestrosa
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2015
Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice
ES Chan, C Chen, GM Cole, BS Wong
Scientific Reports 2015
Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human Astrocytes
X Han, L Yang, H Du, Q Sun, X Wang, L Cong, X Liu, L Yin, S Li, Y Du
Cellular and Molecular Neurobiology 2015
Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity
CA Grillo, GG Piroli, RC Lawrence, SA Wrighten, AJ Green, SP Wilson, RR Sakai, SJ Kelly, MA Wilson, DD Mott, LP Reagan
Diabetes 2015
Hippocampal insulin resistance and cognitive dysfunction
GJ Biessels, LP Reagan
Nature Reviews Neuroscience 2015
Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease
G Verdile, KN Keane, VF Cruzat, S Medic, M Sabale, J Rowles, N Wijesekara, RN Martins, PE Fraser, P Newsholme
Mediators of Inflammation 2015
Effect of Cholesterol Reduction on Receptor Signaling in Neurons
K Fukui, HA Ferris, CR Kahn
The Journal of biological chemistry 2015
Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance
G Gontier, C George, Z Chaker, M Holzenberger, S Aïd
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Tissue-specific insulin signaling in the regulation of metabolism and aging: Insulin Signaling in Metabolism and Aging
J Zhang, F Liu
IUBMB Life 2014
Insulin Action in Brain Regulates Systemic Metabolism and Brain Function
A Kleinridders, HA Ferris, W Cai, CR Kahn
Diabetes 2014
A Network-Based Classification Model for Deriving Novel Drug-Disease Associations and Assessing Their Molecular Actions
M Oh, J Ahn, Y Yoon, A Porollo
PloS one 2014
Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity
AP Arruda, BM Pers, G Parlakgül, E Güney, K Inouye, GS Hotamisligil
Nature Medicine 2014
Brain insulin resistance in Alzheimer’s disease and its potential treatment with GLP-1 analogs
K Talbot
Neurodegenerative Disease Management 2014
The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease
K Talbot, HY Wang
Alzheimer's and Dementia 2014
Inconsistencies and controversies surrounding the Amyloid Hypothesis of Alzheimer’s disease
GP Morris, IA Clark, B Vissel
Acta Neuropathologica Communications 2014
miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling
W Kim, Y Lee, ND McKenna, M Yi, F Simunovic, Y Wang, B Kong, RJ Rooney, H Seo, RM Stephens, KC Sonntag
Neurobiology of Aging 2014
Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury
NH Greig, D Tweedie, L Rachmany, Y Li, V Rubovitch, S Schreiber, YH Chiang, BJ Hoffer, J Miller, DK Lahiri, K Sambamurti, RE Becker, CG Pick
Alzheimer's and Dementia 2014
Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models
JJ Ramos-Rodriguez, S Molina-Gil, O Ortiz-Barajas, M Jimenez-Palomares, G Perdomo, I Cozar-Castellano, AM Lechuga-Sancho, M Garcia-Alloza
PloS one 2014
Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice
QR Ong, ES Chan, ML Lim, GM Cole, BS Wong
Scientific Reports 2014
Does the brain shrink as the waist expands?
AA Willette, D Kapogiannis
Ageing Research Reviews 2014
Deregulation of brain insulin signaling in Alzheimer’s disease
Y Chen, Y Deng, B Zhang, CX Gong
Neuroscience Bulletin 2014
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain
M Perluigi, G Pupo, A Tramutola, C Cini, R Coccia, E Barone, E Head, DA Butterfield, FD Domenico
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014
Type 2 diabetes as a risk factor for cognitive impairment: current insights
H Umegaki
Clinical Interventions in Aging 2014
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies
M Yarchoan, JB Toledo, EB Lee, Z Arvanitakis, H Kazi, LY Han, N Louneva, VM Lee, SF Kim, JQ Trojanowski, SE Arnold
Acta Neuropathologica 2014
Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions
JB Halter, N Musi, FM Horne, JP Crandall, A Goldberg, L Harkless, WR Hazzard, ES Huang, MS Kirkman, J Plutzky, KE Schmader, S Zieman, KP High
Diabetes 2014
Role of insulin resistance in Alzheimer’s disease
Z Cai, M Xiao, L Chang, LJ Yan
Metabolic Brain Disease 2014
Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes
R Agrawal, Y Zhuang, BP Cummings, KL Stanhope, JL Graham, PJ Havel, F Gomez-Pinilla
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014
MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons
W Kim, H Noh, Y Lee, J Jeon, A Shanmugavadivu, DL McPhie, KS Kim, BM Cohen, H Seo, KC Sonntag
Molecular Neurobiology 2014
Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury
Y Terawaki, T Nomiyama, T Kawanami, Y Hamaguchi, H Takahashi, T Tanaka, K Murase, R Nagaishi, M Tanabe, T Yanase
Cardiovascular Diabetology 2014
Vascular hippocampal plasticity after aerobic exercise in older adults
A Maass, S Düzel, M Goerke, A Becke, U Sobieray, K Neumann, M Lövden, U Lindenberger, L Bäckman, R Braun-Dullaeus, D Ahrens, HJ Heinze, NG Müller, E Düzel
Molecular Psychiatry 2014
Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease
M Yarchoan, SE Arnold
Diabetes 2014
Axonal Transport Defects in Alzheimer’s Disease
ZX Wang, L Tan, JT Yu
Molecular Neurobiology 2014
Synopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases
NR Jabir, CK Firoz, SS Baeesa, GM Ashraf, S Akhtar, W Kamal, MA Kamal, S Tabrez
CNS Neuroscience & Therapeutics 2014
New drug treatments show neuroprotective effects in Alzheimer′s and Parkinson′s diseases
C Hölscher
NEURAL REGEN RES 2014
Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates
L Forny-Germano, NM e Silva, AF Batista, J Brito-Moreira, M Gralle, SE Boehnke, BC Coe, A Lablans, SA Marques, AM Martinez, WL Klein, JC Houzel, ST Ferreira, DP Munoz, FG Felice
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Linking Alzheimer’s Disease and Type 2 Diabetes Mellitus via Aberrant Insulin Signaling and Inflammation
Kamal MA, Priyamvada S, Anbazhagan AN, Jabir NR, Tabrez S, Greig NH
CNS & neurological disorders drug targets 2014
Alzheimer’s disease and insulin resistance: translating basic science into clinical applications
Fernanda De Felice
Journal of Clinical Investigation 2013
Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling
M Sadagurski, MF White
Endocrinology and metabolism clinics of North America 2013
Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial
AJ Hanson, JL Bayer-Carter, PS Green, TJ Montine, CW Wilkinson, LD Baker, GS Watson, LM Bonner, M Callaghan, JB Leverenz, E Tsai, N Postupna, J Zhang, J Lampe, S Craft
JAMA neurology 2013
New therapeutic strategy for Alzheimer's disease using antidiabetes agents
K Yokono
Journal of Diabetes Investigation 2013
(−)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus
N Jia, K Han, JJ Kong, XM Zhang, S Sha, GR Ren, YP Cao
Molecular and Cellular Biochemistry 2013
The neurodegeneration in Alzheimer disease and the prion protein
G Forloni, A Sclip, T Borsello, C Balducci
Prion 2013
Insulin resistance in the brain: A new therapeutic target for Alzheimer's disease
H Umegaki
Journal of Diabetes Investigation 2013
Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas
Y Seino, D Yabe
Journal of Diabetes Investigation 2013
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study
VK Ramanan, SL Risacher, K Nho, S Kim, S Swaminathan, L Shen, TM Foroud, H Hakonarson, MJ Huentelman, PS Aisen, RC Petersen, RC Green, CR Jack, RA Koeppe, WJ Jagust, MW Weiner, AJ Saykin
Molecular Psychiatry 2013
Non-cognitive symptoms and related conditions in the Alzheimer’s disease: a literature review
F Raudino
Neurological Sciences 2013
Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
D Tweedie, L Rachmany, V Rubovitch, E Lehrmann, Y Zhang, KG Becker, E Perez, J Miller, BJ Hoffer, NH Greig, CG Pick
Experimental Neurology 2013
Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence
J Freiherr, M Hallschmid, WH 2nd, YF Brünner, CD Chapman, C Hölscher, S Craft, FG de Felice, C Benedict
CNS Drugs 2013
Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals
M Bomba, D Ciavardelli, E Silvestri, LM Canzoniero, R Lattanzio, P Chiappini, M Piantelli, CD Ilio, A Consoli, SL Sensi
Cell Death and Disease 2013
Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model
V Parthsarathy, C Hölscher
PloS one 2013
Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art
SM de la Monte
Expert Opinion on Drug Delivery 2013
Type 2 diabetes and cognitive compromise: potential roles of diabetes-related therapies
E Kravitz, J Schmeidler, MS Beeri
Endocrinology and metabolism clinics of North America 2013
From integrative disease modeling to predictive, preventive, personalized and participatory (P4) medicine
E Younesi, M Hofmann-Apitius
The EPMA Journal 2013
Increased tau phosphorylation and impaired brain insulin/IGF signaling in mice fed a high fat/high cholesterol diet
Narayan R. Bhat, Lakshmi Thirumangalakudi, Lakshmi Thirumangalakudi
Journal of Alzheimer's disease : JAD 2013
Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols
J Pitt, M Thorner, D Brautigan, J Larner, WL Klein
The FASEB Journal 2013
Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling
Yin F, Jiang T, Cadenas E
Biochemical Society Transactions 2013
Brain insulin resistance demonstrated in Alzheimer’s disease occurs with IGF-1 resistance and is closely associated with dysregulated IRS-1 and cognitive decline
Konrad Talbot, Hoau-Yan Wang, Hala Kazi, Li-Ying Han, Kalindi Bakshi, Andres Stucky, Robert Fuino, Krista Kawaguchi, Andrew Samoyedny, Robert Wilson, Zoe Arvanitakis, Julie Schneider, Bryan Wolf, David Bennett, John Trojanowski, Steven Arnold
Journal of Clinical Investigation 2012
Alzheimer disease: The New Promise
Warren James Strittmatter
Journal of Clinical Investigation 2012
The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation
YJ Park, Z Ao, TJ Kieffer, H Chen, N Safikhan, DM Thompson, M Meloche, GL Warnock, L Marzban
Diabetologia 2012
Alzheimer disease: Insulin resistance and AD--extending the translational path
S Craft
Nature Reviews Neurology 2012
Cognitive impairment in diabetic patients: Can diabetic control prevent cognitive decline?
T Kawamura, T Umemura, N Hotta
Journal of Diabetes Investigation 2012
Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice
L Rachmany, D Tweedie, Y Li, V Rubovitch, HW Holloway, J Miller, BJ Hoffer, NH Greig, CG Pick
AGE 2012
The DPP-4 inhibitor linagliptin counteracts stroke in the normal and diabetic mouse brain: a comparison with glimepiride
V Darsalia, H Ortsäter, A Olverling, E Darlöf, P Wolbert, T Nyström, T Klein, Å Sjöholm, C Patrone
Diabetes 2012
The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease
CM Long-Smith, S Manning, PL McClean, MF Coakley, DJ OHalloran, C Holscher, C ONeill
NeuroMolecular Medicine 2012
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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