Citations to this article

Good COP1 or bad COP1? In vivo veritas
Wenyi Wei, William G. Kaelin Jr.
Wenyi Wei, William G. Kaelin Jr.
Published March 14, 2011
Citation Information: J Clin Invest. 2011;121(4):1263-1265. https://doi.org/10.1172/JCI57080.
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Good COP1 or bad COP1? In vivo veritas

Abstract

The evolutionarily conserved protein COP1 has been shown to operate as an E3 ubiquitin ligase complex, and a number of putative substrates have been identified, including the c-JUN oncoprotein and p53 tumor suppressor protein. New work by Migliorini and colleagues described in the current issue of JCI demonstrates that COP1 acts as a tumor suppressor in vivo and does so, at least in part, by promoting the destruction of c-JUN. These findings challenge the view that COP1 regulates p53 stability and call into question the wisdom of developing COP1 inhibitors as potential anticancer agents.

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Wenyi Wei, William G. Kaelin Jr.

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Citations to this article (16)

Title and authors Publication Year
In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target
Wang X, Tokheim C, Gu SS, Wang B, Tang Q, Li Y, Traugh N, Zeng Z, Zhang Y, Li Z, Zhang B, Fu J, Xiao T, Li W, Meyer CA, Chu J, Jiang P, Cejas P, Lim K, Long H, Brown M, Liu XS 		Cell 2021
EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis
HH Choi, S Zou, J Wu, H Wang, L Phan, K Li, P Zhang, D Chen, Q Liu, B Qin, TA Nguyen, SC Yeung, L Fang, MH Lee 		Advanced Science 2020
Correlation of constitutive photomorphogenic 1 (COP1) and p27 tumor suppressor protein expression in ovarian cancer
EJ Ko, YL Oh, HY Kim, WK Eo, H Kim, KH Kim, SB Koh, MS Ock, YH Choi, A Kim, HH Choi, EJ Park, HJ Cha 		Genes & Genomics 2019
Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway
S Bang, S Kaur, M Kurokawa 		International journal of molecular sciences 2019
CRY arrests Cop1 to regulate circadian rhythms in mammals
C Lee 		Cell division 2019
Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy
AK Ernst, A Putscher, TR Samatov, A Suling, VV Galatenko, MY Shkurnikov, EN Knyazev, AG Tonevitsky, T Haalck, T Lange, H Maar, JS Schwarz, K Riecken, U Schumacher, D Wicklein, F Mattei 		PloS one 2018
The Ubiquitin Ligase COP1 Promotes Glioma Cell Proliferation by Preferentially Downregulating Tumor Suppressor p53
S Zou, Y Zhu, B Wang, F Qian, X Zhang, L Wang, C Fu, H Bao, M Xie, S Gao, R Yu, H Shi 		Molecular Neurobiology 2016
High expression of constitutive photomorphogenic 1 (COP1) is associated with poor prognosis in bladder cancer
J Li, L Wang, R Xiao, Q Pan, H Huang, R Kuang 		Tumor Biology 2016
HuCOP1 contributes to the regulation of DNA repair in keratinocytes.
Fazekas B, Carty MP, Németh I, Kemény L, Széll M, Ádám É 		Molecular and Cellular Biochemistry 2016
COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth
HH Choi, L Phan, PC Chou, CH Su, SC Yeung, JS Chen, MH Lee 		Oncotarget 2015
Regulating the stability and localization of CDK inhibitor p27 Kip1 via CSN6-COP1 axis
HH Choi, S Guma, L Fang, L Phan, C Ivan, K Baggerly, A Sood, MH Lee 		Cell cycle (Georgetown, Tex.) 2015
COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer
M Ouyang, H Wang, J Ma, W Lü, J Li, C Yao, G Chang, J Bi, S Wang, W Wang 		BMC Cancer 2015
CSN6 deregulation impairs genome integrity in a COP1-dependent pathway
Choi HH, Su CH, Fang L, Zhang J, Yeung SC, Lee MH 		Oncotarget 2015
Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor
G Lu, Q Zhang, Y Huang, J Song, R Tomaino, T Ehrenberger, E Lim, W Liu, RT Bronson, M Bowden, J Brock, IE Krop, DA Dillon, SP Gygi, GB Mills, AL Richardson, S Signoretti, MB Yaffe, WG Kaelin 		Cancer Cell 2014
APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction
L Wan, M Tan, J Yang, H Inuzuka, X Dai, T Wu, J Liu, S Shaik, G Chen, J Deng, M Malumbres, A Letai, MW Kirschner, Y Sun, W Wei 		Developmental Cell 2014
Spotlight on the role of COP1 in tumorigenesis
JC Marine 		Nature Reviews Cancer 2012

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