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Citations to this article

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice
Weiguang Zhao, … , Brendan F. Boyce, Stephen M. Krane
Weiguang Zhao, … , Brendan F. Boyce, Stephen M. Krane
Published February 15, 1999
Citation Information: J Clin Invest. 1999;103(4):517-524. https://doi.org/10.1172/JCI5481.
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Article

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice

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Abstract

Parathyroid hormone (PTH) stimulates bone resorption by acting directly on osteoblasts/stromal cells and then indirectly to increase differentiation and function of osteoclasts. PTH acting on osteoblasts/stromal cells increases collagenase gene transcription and synthesis. To assess the role of collagenase in the bone resorptive actions of PTH, we used mice homozygous (r/r) for a targeted mutation (r) in Col1a1 that are resistant to collagenase cleavage of type I collagen. Human PTH(1–34) was injected subcutaneously over the hemicalvariae in wild-type (+/+) or r/r mice four times daily for three days. Osteoclast numbers, the size of the bone marrow spaces and periosteal proliferation were increased in calvariae from PTH-treated +/+ mice, whereas in r/r mice, PTH-induced bone resorption responses were minimal. The r/r mice were not resistant to other skeletal effects of PTH because abundant interstitial collagenase mRNA was detected in the calvarial periosteum of PTH-treated, but not vehicle-treated, r/r and +/+ mice. Calcemic responses, 0.5–10 hours after intraperitoneal injection of PTH, were blunted in r/r mice versus +/+ mice. Thus, collagenase cleavage of type I collagen is necessary for PTH induction of osteoclastic bone resorption.

Authors

Weiguang Zhao, Michael H. Byrne, Brendan F. Boyce, Stephen M. Krane

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The Parathyroids 2001
Macrophage Migration Inhibitory Factor Up-regulates Matrix Metalloproteinase-9 and -13 in Rat Osteoblasts: RELEVANCE TO INTRACELLULAR SIGNALING PATHWAYS
S Onodera, J Nishihira, K Iwabuchi, Y Koyama, K Yoshida, S Tanaka, A Minami
The Journal of biological chemistry 2001
Physical Interaction of the Activator Protein-1 Factors c-Fos and c-Jun with Cbfa1 for Collagenase-3 Promoter Activation
RC D'Alonzo, N Selvamurugan, G Karsenty, NC Partridge
The Journal of biological chemistry 2001
L’ostéoclaste et les mécanismes moléculaires de la résorption osseuse
R Baron
médecine/sciences 2001
Inability of collagenase to cleave type I collagen in vivo is associated with osteocyte apoptosis and excessive bone deposition
Weiguang Zhao, Michael H. Byrne, Yingmin Wang, Stephen M. Krane
Journal of Clinical Investigation 2000
Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture
Y Okada, JA Lorenzo, AM Freeman, M Tomita, SG Morham, LG Raisz, CC Pilbeam
Journal of Clinical Investigation 2000
Alendronate Stimulates Collagenase 3 Expression in Osteoblasts by Posttranscriptional Mechanisms
S Varghese, E Canalis
Journal of Bone and Mineral Research 2000
Osteoclast formation and resorption
UH Lerner
Matrix Biology 2000
Bone resorption induced by 1α,25 dihydroxyvitamin D3 in vivo is not altered by inactivation of the plasminogen activator inhibitor 1
E Daci, A Verstuyf, K Moermans, R Bouillon, G Carmeliet
Bone 2000
Proteinases in bone resorption: obvious and less obvious roles
JM Delaissé, MT Engsig, V Everts, MC Ovejero, M Ferreras, L Lund, TH Vu, Z Werb, B Winding, A Lochter, MA Karsdal, T Troen, T Kirkegaard, T Lenhard, AM Heegaard, L Neff, R Baron, NT Foged
Clinica Chimica Acta 2000
Corticosteroids and Fractures: A Close Encounter of the Third Cell Kind
SC Manolagas
Journal of Bone and Mineral Research 2000
Regulation of collagenase-3 gene expression in osteoblastic and non-osteoblastic cell lines
N Selvamurugan, RJ Brown, NC Partridge
Journal of Cellular Biochemistry 2000
Platelet-derived growth factor induces collagenase 3 transcription in osteoblasts through the activator protein 1 complex
S Rydziel, D Durant, E Canalis
Journal of Cellular Physiology 2000
Collagenase-3 (MMP-13) and Integral Membrane Protein 2a (Itm2a) are Marker Genes of Chondrogenic/Osteoblastic Cells in Bone Formation: Sequential Temporal, and Spatial Expression of Itm2a, Alkaline Phosphatase, MMP-13, and Osteocalcin in the Mouse
JP Tuckermann, K Pittois, NC Partridge, J Merregaert, P Angel
Journal of Bone and Mineral Research 2000
Constitutive Expression and Regulation of Collagenase-3 in Human Breast Cancer Cells
N Selvamurugan, NC Partridge
Molecular Cell Biology Research Communications 2000
Effects of Dioxin and Estrogen on Collagenase-3 in UMR 106-01 Osteosarcoma Cells
NC Partridge, GJ Fiacco, HW Walling, OY Barmina, JJ Jeffrey, MF Ruh
Archives of Biochemistry and Biophysics 2000
Impaired Bone Resorption to Prostaglandin E 2 in Prostaglandin E Receptor EP4-knockout Mice
C Miyaura, M Inada, T Suzawa, Y Sugimoto, F Ushikubi, A Ichikawa, S Narumiya, T Suda
The Journal of biological chemistry 2000
Parathyroid Hormone Regulation of the Rat Collagenase-3 Promoter by Protein Kinase A-dependent Transactivation of Core Binding Factor α1
N Selvamurugan, MR Pulumati, DR Tyson, NC Partridge
The Journal of biological chemistry 2000
Identification of the 183 RWTNNFREY 191 Region as a Critical Segment of Matrix Metalloproteinase 1 for the Expression of Collagenolytic Activity
L Chung, K Shimokawa, D Dinakarpandian, F Grams, GB Fields, H Nagase
The Journal of biological chemistry 2000
Developmental Regulation of Collagenase-3 mRNA in Normal, Differentiating Osteoblasts through the Activator Protein-1 and the runt Domain Binding Sites
SK Winchester, N Selvamurugan, RC D'Alonzo, NC Partridge
The Journal of biological chemistry 2000
Basic Fibroblast Growth Factor Stimulates Collagenase-3 Promoter Activity in Osteoblasts through an Activator Protein-1-Binding Site*
S Varghese, S Rydziel, E Canalis
Endocrinology 2000
Bone Resorption by Osteoclasts
SL Teitelbaum
Science 2000
Molecular, biochemical and functional analysis of a novel and developmentally important fibrillar collagen (Hcol-I) in hydra
R Deutzmann, S Fowler, X Zhang, K Boone, S Dexter, RP Boot-Handford, R Rachel, MP Sarras
Development (Cambridge, England) 2000
A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process
AA Leontovich, J Zhang, K Shimokawa, H Nagase, MP Sarras
Development (Cambridge, England) 2000
Stemming bone loss by suppressing apoptosis
JM Hock
Journal of Clinical Investigation 1999
Overview: Destruction of the Extracellular Matrix in Rheumatoid Arthritis
S Krane
Arthritis research 1999
Osteoporosis
DL Glaser, FS Kaplan
Spine 1997
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene
LM Calvi, NA Sims, JL Hunzelman, MC Knight, A Giovannetti, JM Saxton, HM Kronenberg, R Baron, E Schipani
Genes & development 1994

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