Parathyroid hormone (PTH) stimulates bone resorption by acting directly on osteoblasts/stromal cells and then indirectly to increase differentiation and function of osteoclasts. PTH acting on osteoblasts/stromal cells increases collagenase gene transcription and synthesis. To assess the role of collagenase in the bone resorptive actions of PTH, we used mice homozygous (r/r) for a targeted mutation (r) in Col1a1 that are resistant to collagenase cleavage of type I collagen. Human PTH(1–34) was injected subcutaneously over the hemicalvariae in wild-type (+/+) or r/r mice four times daily for three days. Osteoclast numbers, the size of the bone marrow spaces and periosteal proliferation were increased in calvariae from PTH-treated +/+ mice, whereas in r/r mice, PTH-induced bone resorption responses were minimal. The r/r mice were not resistant to other skeletal effects of PTH because abundant interstitial collagenase mRNA was detected in the calvarial periosteum of PTH-treated, but not vehicle-treated, r/r and +/+ mice. Calcemic responses, 0.5–10 hours after intraperitoneal injection of PTH, were blunted in r/r mice versus +/+ mice. Thus, collagenase cleavage of type I collagen is necessary for PTH induction of osteoclastic bone resorption.
Weiguang Zhao, Michael H. Byrne, Brendan F. Boyce, Stephen M. Krane
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Bone | 2000 |
Proteinases in bone resorption: obvious and less obvious roles
JM Delaissé, MT Engsig, V Everts, MC Ovejero, M Ferreras, L Lund, TH Vu, Z Werb, B Winding, A Lochter, MA Karsdal, T Troen, T Kirkegaard, T Lenhard, AM Heegaard, L Neff, R Baron, NT Foged |
Clinica Chimica Acta | 2000 |
Corticosteroids and Fractures: A Close Encounter of the Third Cell Kind
SC Manolagas |
Journal of Bone and Mineral Research | 2000 |
Regulation of collagenase-3 gene expression in osteoblastic and non-osteoblastic cell lines
N Selvamurugan, RJ Brown, NC Partridge |
Journal of Cellular Biochemistry | 2000 |
Platelet-derived growth factor induces collagenase 3 transcription in osteoblasts through the activator protein 1 complex
S Rydziel, D Durant, E Canalis |
Journal of Cellular Physiology | 2000 |
Collagenase-3 (MMP-13) and Integral Membrane Protein 2a (Itm2a) are Marker Genes of Chondrogenic/Osteoblastic Cells in Bone Formation: Sequential Temporal, and Spatial Expression of Itm2a, Alkaline Phosphatase, MMP-13, and Osteocalcin in the Mouse
JP Tuckermann, K Pittois, NC Partridge, J Merregaert, P Angel |
Journal of Bone and Mineral Research | 2000 |
Constitutive Expression and Regulation of Collagenase-3 in Human Breast Cancer Cells
N Selvamurugan, NC Partridge |
Molecular Cell Biology Research Communications | 2000 |
Effects of Dioxin and Estrogen on Collagenase-3 in UMR 106-01 Osteosarcoma Cells
NC Partridge, GJ Fiacco, HW Walling, OY Barmina, JJ Jeffrey, MF Ruh |
Archives of Biochemistry and Biophysics | 2000 |
Impaired Bone Resorption to Prostaglandin E 2 in Prostaglandin E Receptor EP4-knockout Mice
C Miyaura, M Inada, T Suzawa, Y Sugimoto, F Ushikubi, A Ichikawa, S Narumiya, T Suda |
The Journal of biological chemistry | 2000 |
Parathyroid Hormone Regulation of the Rat Collagenase-3 Promoter by Protein Kinase A-dependent Transactivation of Core Binding Factor α1
N Selvamurugan, MR Pulumati, DR Tyson, NC Partridge |
The Journal of biological chemistry | 2000 |
Identification of the 183 RWTNNFREY 191 Region as a Critical Segment of Matrix Metalloproteinase 1 for the Expression of Collagenolytic Activity
L Chung, K Shimokawa, D Dinakarpandian, F Grams, GB Fields, H Nagase |
The Journal of biological chemistry | 2000 |
Developmental Regulation of Collagenase-3 mRNA in Normal, Differentiating Osteoblasts through the Activator Protein-1 and the runt Domain Binding Sites
SK Winchester, N Selvamurugan, RC D'Alonzo, NC Partridge |
The Journal of biological chemistry | 2000 |
Basic Fibroblast Growth Factor Stimulates Collagenase-3 Promoter Activity in Osteoblasts through an Activator Protein-1-Binding Site*
S Varghese, S Rydziel, E Canalis |
Endocrinology | 2000 |
Bone Resorption by Osteoclasts
SL Teitelbaum |
Science | 2000 |
Molecular, biochemical and functional analysis of a novel and developmentally important fibrillar collagen (Hcol-I) in hydra
R Deutzmann, S Fowler, X Zhang, K Boone, S Dexter, RP Boot-Handford, R Rachel, MP Sarras |
Development (Cambridge, England) | 2000 |
A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process
AA Leontovich, J Zhang, K Shimokawa, H Nagase, MP Sarras |
Development (Cambridge, England) | 2000 |
Stemming bone loss by suppressing apoptosis
JM Hock |
Journal of Clinical Investigation | 1999 |
Overview: Destruction of the Extracellular Matrix in Rheumatoid Arthritis
S Krane |
Arthritis research | 1999 |
Osteoporosis
DL Glaser, FS Kaplan |
Spine | 1997 |
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene
LM Calvi, NA Sims, JL Hunzelman, MC Knight, A Giovannetti, JM Saxton, HM Kronenberg, R Baron, E Schipani |
Genes & development | 1994 |