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Citations to this article

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations
Marina Grachtchouk, … , Monique Verhaegen, Andrzej A. Dlugosz
Marina Grachtchouk, … , Monique Verhaegen, Andrzej A. Dlugosz
Published April 25, 2011
Citation Information: J Clin Invest. 2011;121(5):1768-1781. https://doi.org/10.1172/JCI46307.
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Research Article Article has an altmetric score of 11

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

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Abstract

Uncontrolled Hedgehog (Hh) signaling leads to the development of basal cell carcinoma (BCC), the most common human cancer, but the cell of origin for BCC is unclear. While Hh pathway dysregulation is common to essentially all BCCs, there exist multiple histological subtypes, including superficial and nodular variants, raising the possibility that morphologically distinct BCCs may arise from different cellular compartments in skin. Here we have shown that induction of a major mediator of Hh signaling, GLI2 activator (GLI2ΔN), selectively in stem cells of resting hair follicles in mice, induced nodular BCC development from a small subset of cells in the lower bulge and secondary hair germ compartments. Tumorigenesis was markedly accelerated when GLI2ΔN was induced in growing hair follicles. In contrast, induction of GLI2ΔN in epidermis led to the formation of superficial BCCs. Expression of GLI2ΔN at reduced levels in mice yielded lesions resembling basaloid follicular hamartomas, which have previously been linked to low-level Hh signaling in both mice and humans. Our data show that the cell of origin, tissue context (quiescent versus growing hair follicles), and level of oncogenic signaling can determine the phenotype of Hh/Gli-driven skin tumors, with high-level signaling required for development of superficial BCC-like tumors from interfollicular epidermis and nodular BCC-like tumors from hair follicle stem cells.

Authors

Marina Grachtchouk, Joanna Pero, Steven H. Yang, Alexandre N. Ermilov, L. Evan Michael, Aiqin Wang, Dawn Wilbert, Rajiv M. Patel, Jennifer Ferris, James Diener, Mary Allen, Seokchun Lim, Li-Jyun Syu, Monique Verhaegen, Andrzej A. Dlugosz

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
Citations: 2 3 2 6 5 5 5 11 5 6 6 14 14 12 3 1 100
Citation information
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Citations to this article in year 2009 (1)

Title and authors Publication Year
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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ISSN: 0021-9738 (print), 1558-8238 (online)

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