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Growing a tumor stroma: a role for granulin and the bone marrow
Andrew Bateman
Andrew Bateman
Published January 25, 2011
Citation Information: J Clin Invest. 2011;121(2):516-519. https://doi.org/10.1172/JCI46088.
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Growing a tumor stroma: a role for granulin and the bone marrow

Abstract

The tumor stroma is critical in cancer progression; understanding its formation is therefore important biologically and therapeutically. In this issue of the JCI, Elkabets et al. report on the generation of data in mice that lead them to propose that certain tumors can stimulate the growth of a second otherwise quiescent or indolent tumor in the same animal by stimulating stromal formation. Granulin-expressing Sca+Kit– hematopoietic progenitor cells in the bone marrow of the tumor host were required to mediate this effect. These data shed new light on the importance of the bone marrow in tumor growth and the role of granulin in carcinogenesis.

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Andrew Bateman

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Citations to this article (5)

Title and authors Publication Year
Translational aspects in targeting the stromal tumour microenvironment: From bench to bedside
R Bhome, HA Saihati, RW Goh, MD Bullock, JN Primrose, GJ Thomas, AE Sayan, AH Mirnezami 		New Horizons in Translational Medicine 2016
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Hypothermia Activates Adipose Tissue to Promote Malignant Lung Cancer Progression
G Du, B Zhao, Y Zhang, T Sun, W Liu, J Li, Y Liu, Y Wang, H Li, X Hou 		PloS one 2013
The extracellular matrix: A dynamic niche in cancer progression
P Lu, VM Weaver, Z Werb 		The Journal of Cell Biology 2012
Structure, Function, and Mechanism of Progranulin; the Brain and Beyond
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