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Citations to this article

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts
Xiaohua Ni, … , Theodore L. DeWeese, Shawn E. Lupold
Xiaohua Ni, … , Theodore L. DeWeese, Shawn E. Lupold
Published May 9, 2011
Citation Information: J Clin Invest. 2011;121(6):2383-2390. https://doi.org/10.1172/JCI45109.
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Research Article Oncology Article has an altmetric score of 10

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

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Abstract

Dose-escalated radiation therapy for localized prostate cancer (PCa) has a clear therapeutic benefit; however, escalated doses may also increase injury to noncancerous tissues. Radiosensitizing agents can improve ionizing radiation (IR) potency, but without targeted delivery, these agents will also sensitize surrounding normal tissues. Here we describe the development of prostate-targeted RNAi agents that selectively sensitized prostate-specific membrane antigen–positive (PSMA-positive) cells to IR. siRNA library screens identified DNA-activated protein kinase, catalytic polypeptide (DNAPK) as an ideal radiosensitization target. DNAPK shRNAs, delivered by PSMA-targeting RNA aptamers, selectively reduced DNAPK in PCa cells, xenografts, and human prostate tissues. Aptamer-targeted DNAPK shRNAs, combined with IR, dramatically and specifically enhanced PSMA-positive tumor response to IR. These findings support aptamer-shRNA chimeras as selective sensitizing agents for the improved treatment of high-risk localized PCa.

Authors

Xiaohua Ni, Yonggang Zhang, Judit Ribas, Wasim H. Chowdhury, Mark Castanares, Zhewei Zhang, Marikki Laiho, Theodore L. DeWeese, Shawn E. Lupold

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Total citations by year

Year: 2025 2024 2023 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
Citations: 3 2 1 1 3 2 5 2 5 13 13 11 10 5 1 77
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2015 (13)

Title and authors Publication Year
Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer-siRNA Chimeras in Human Tumor Xenografts
X Ni, Y Zhang, K Zennami, M Castanares, A Mukherjee, RR Raval, H Zhou, TL DeWeese, SE Lupold
Molecular cancer therapeutics 2015
Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine
D Xiang, S Shigdar, G Qiao, T Wang, AZ Kouzani, SF Zhou, L Kong, Y Li, C Pu, W Duan
Theranostics 2015
Smart functional nucleic acid chimeras: Enabling tissue specific RNA targeting therapy
LJ Aaldering, H Tayeb, S Krishnan, S Fletcher, SD Wilton, RN Veedu
RNA biology 2015
Characterization of a novel metastatic prostate cancer cell line of LNCaP origin: Characterization of JHU-LNCaP-SM
MA Castanares, BT Copeland, WH Chowdhury, MM Liu, R Rodriguez, MG Pomper, SE Lupold, CA Foss
The Prostate 2015
Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity
K Waugh, S Leach, J Slansky
Human vaccines 2015
Methods in Molecular Biology
WH Thiel, KW Thiel, KS Flenker, T Bair, AJ Dupuy, JO McNamara, FJ Miller, PH Giangrande
Methods in molecular biology (Clifton, N.J.) 2015
A Highlight of Recent Advances in Aptamer Technology and Its Application
H Sun, Y Zu
Molecules (Basel, Switzerland) 2015
A cell-based high-throughput screening assay for radiation susceptibility using automated cell counting
J Hodzic, I Dingjan, MJ Maas, IH van der Meulen-Muileman, RX de Menezes, S Heukelom, M Verheij, WR Gerritsen, AA Geldof, B Triest, VW van Beusechem
Radiation Oncology 2015
A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation
K Hatano, B Kumar, Y Zhang, JB Coulter, M Hedayati, B Mears, X Ni, TA Kudrolli, WH Chowdhury, R Rodriguez, TL DeWeese, SE Lupold
Nucleic Acids Research 2015
Oligonucleotide therapies – the past and the present
KE Lundin, OI Gissberg, E SMITH
Human Gene Therapy 2015
Aptamer–Drug Conjugates
G Zhu, G Niu, X Chen
Bioconjugate Chemistry 2015
Identifying high-affinity aptamer ligands with defined cross-reactivity using high-throughput guided systematic evolution of ligands by exponential enrichment
A Levay, R Brenneman, J Hoinka, D Sant, M Cardone, G Trinchieri, TM Przytycka, A Berezhnoy
Nucleic Acids Research 2015
Screening and Identifying a Novel ssDNA Aptamer against Alpha-fetoprotein Using CE-SELEX
L Dong, Q Tan, W Ye, D Liu, H Chen, H Hu, D Wen, Y Liu, Y Cao, J Kang, J Fan, W Guo, W Wu
Scientific Reports 2015

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