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Christian Weber, … , Tobias Junt, Alma Zernecke
Published June 1, 2011
Citation Information: J Clin Invest. 2011;121(7):2898-2910. https://doi.org/10.1172/JCI44925.
Citation Information: J Clin Invest. 2011;121(7):2898-2910. https://doi.org/10.1172/JCI44925.
Abstract
Immune mechanisms are known to control the pathogenesis of atherosclerosis. However, the exact role of DCs, which are essential for priming of immune responses, remains elusive. We have shown here that the DC-derived chemokine CCL17 is present in advanced human and mouse atherosclerosis and that CCL17+ DCs accumulate in atherosclerotic lesions. In atherosclerosis-prone mice, Ccl17 deficiency entailed a reduction of atherosclerosis, which was dependent on Tregs. Expression of CCL17 by DCs limited the expansion of Tregs by restricting their maintenance and precipitated atherosclerosis in a mechanism conferred by T cells. Conversely, a blocking antibody specific for CCL17 expanded Tregs and reduced atheroprogression. Our data identify DC-derived CCL17 as a central regulator of Treg homeostasis, implicate DCs and their effector functions in atherogenesis, and suggest that CCL17 might be a target for vascular therapy.
Authors
Christian Weber, Svenja Meiler, Yvonne Döring, Miriam Koch, Maik Drechsler, Remco T.A. Megens, Zuzanna Rowinska, Kiril Bidzhekov, Caroline Fecher, Eliana Ribechini, Marc A.M.J. van Zandvoort, Christoph J. Binder, Ivett Jelinek, Mihail Hristov, Louis Boon, Steffen Jung, Thomas Korn, Manfred B. Lutz, Irmgard Förster, Martin Zenke, Thomas Hieronymus, Tobias Junt, Alma Zernecke
Total citations by year
Citation information
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Phenotypic and Functional Heterogeneity of Macrophages and Dendritic Cell Subsets in the Healthy and Atherosclerosis-Prone Aorta
MJ Butcher, EV Galkina |
Frontiers in physiology | 2012 |
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microRNAs in the regulation of dendritic cell functions in inflammation and atherosclerosis
M Busch, A Zernecke |
Journal of Molecular Medicine | 2012 |
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Dendritic cells and regulatory T cells in atherosclerosis
C Cheong, JH Choi |
Molecules and Cells | 2012 |
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microRNA-181a represses ox-LDL-stimulated inflammatory response in dendritic cell by targeting c-Fos
C Wu, Y Gong, J Yuan, W Zhang, G Zhao, H Li, A Sun, , Y Zou, J Ge |
Journal of lipid research | 2012 |
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Interleukin-27 Receptor Limits Atherosclerosis in Ldlr−/− Mice
EK Koltsova, G Kim, KM Lloyd, CJ Saris, S von Vietinghoff, M Kronenberg, K Ley |
Circulation research | 2012 |
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Chemokines: established and novel targets in atherosclerosis
RR Koenen, C Weber |
EMBO Molecular Medicine | 2011 |
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Atherosclerosis: current pathogenesis and therapeutic options
C Weber, H Noels |
Nature Medicine | 2011 |
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