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Citations to this article

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
Eugene P. Rhee, … , Thomas J. Wang, Robert E. Gerszten
Eugene P. Rhee, … , Thomas J. Wang, Robert E. Gerszten
Published March 14, 2011
Citation Information: J Clin Invest. 2011;121(4):1402-1411. https://doi.org/10.1172/JCI44442.
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Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans

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Abstract

Dyslipidemia is an independent risk factor for type 2 diabetes, although exactly which of the many plasma lipids contribute to this remains unclear. We therefore investigated whether lipid profiling can inform diabetes prediction by performing liquid chromatography/mass spectrometry–based lipid profiling in 189 individuals who developed type 2 diabetes and 189 matched disease-free individuals, with over 12 years of follow up in the Framingham Heart Study. We found that lipids of lower carbon number and double bond content were associated with an increased risk of diabetes, whereas lipids of higher carbon number and double bond content were associated with decreased risk. This pattern was strongest for triacylglycerols (TAGs) and persisted after multivariable adjustment for age, sex, BMI, fasting glucose, fasting insulin, total triglycerides, and HDL cholesterol. A combination of 2 TAGs further improved diabetes prediction. To explore potential mechanisms that modulate the distribution of plasma lipids, we performed lipid profiling during oral glucose tolerance testing, pharmacologic interventions, and acute exercise testing. Levels of TAGs associated with increased risk for diabetes decreased in response to insulin action and were elevated in the setting of insulin resistance. Conversely, levels of TAGs associated with decreased diabetes risk rose in response to insulin and were poorly correlated with insulin resistance. These studies identify a relationship between lipid acyl chain content and diabetes risk and demonstrate how lipid profiling could aid in clinical risk assessment.

Authors

Eugene P. Rhee, Susan Cheng, Martin G. Larson, Geoffrey A. Walford, Gregory D. Lewis, Elizabeth McCabe, Elaine Yang, Laurie Farrell, Caroline S. Fox, Christopher J. O’Donnell, Steven A. Carr, Ramachandran S. Vasan, Jose C. Florez, Clary B. Clish, Thomas J. Wang, Robert E. Gerszten

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Total
Citations: 4 26 36 42 38 32 29 25 28 22 23 16 28 17 2 368
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Scientific Reports 2022
Plasma Metabolic Signatures of Healthy Overweight Subjects Challenged With an Oral Glucose Tolerance Test
Fiamoncini J, Donado-Pestana CM, Duarte GB, Rundle M, Thomas EL, Kiselova-Kaneva Y, Gundersen TE, Bunzel D, Trezzi JP, Kulling SE, Hiller K, Sonntag D, Ivanova D, Brennan L, Wopereis S, van Ommen B, Frost G, Bell J, Drevon CA, Daniel H
Frontiers in Nutrition 2022
Genetic Architecture of Plasma Alpha‐Aminoadipic Acid Reveals a Relationship With High‐Density Lipoprotein Cholesterol
Shi M, Wang C, Mei H, Temprosa M, Florez JC, Tripputi M, Merino J, Lipworth L, Shu X, Gerszten RE, Wang TJ, Beckman JA, Gamboa JL, Mosley JD, Ferguson JF
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2022
Deep Lipidomics in Human Plasma: Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation
Eichelmann F, Sellem L, Wittenbecher C, Jäger S, Kuxhaus O, Prada M, Cuadrat R, Jackson KG, Lovegrove JA, Schulze MB
Circulation 2022
Lipidomics in Biomarker Research.
Hornemann T
Handbook of experimental pharmacology 2022
Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes.
Wang F, Baden MY, Guasch-Ferré M, Wittenbecher C, Li J, Li Y, Wan Y, Bhupathiraju SN, Tobias DK, Clish CB, Mucci LA, Eliassen AH, Costenbader KH, Karlson EW, Ascherio A, Rimm EB, Manson JE, Liang L, Hu FB
Diabetologia 2022
Large-scale integrated analysis of genetics and metabolomic data reveals potential links between lipids and colorectal cancer risk
Shu X, Chen Z, Long J, Guo X, Yang Y, Qu C, Ahn YO, Cai Q, Casey G, Gruber SB, Huyghe JR, Jee SH, Jenkins MA, Jia WH, Jung KJ, Kamatani Y, Kim DH, Kim J, Kweon SS, Le Marchand L, Matsuda K, Matsuo K, Newcomb PA, Oh JH, Ose J, Oze I, Pai RK, Pan ZZ, Pharoah PD, Playdon MC, Ren ZF, Schoen RE, Shin A, Shin MH, Shu XO, Sun X, Tangen CM, Tanikawa C, Ulrich CM, van Duijnhoven FJ, Van Guelpen B, Wolk A, Woods MO, Wu AH, Peters U, Zheng W
Cancer epidemiology, biomarkers & prevention 2022
Impaired Amino Acid Metabolism and Its Correlation with Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus
Zhu H, Bai M, Xie X, Wang J, Weng C, Dai H, Chen J, Han F, Lin W
Nutrients 2022
Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice.
Morgan HL, Furse S, Dias IHK, Shabir K, Castellanos M, Khan I, May ST, Holmes N, Carlile M, Sang F, Wright V, Koulman A, Watkins AJ
2022
Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes.
Afshinnia F, Reynolds EL, Rajendiran TM, Soni T, Byun J, Savelieff MG, Looker HC, Nelson RG, Michailidis G, Callaghan BC, Pennathur S, Feldman EL
Annals of Clinical and Translational Neurology 2022
Olive- and Coconut-Oil-Enriched Diets Decreased Secondary Bile Acids and Regulated Metabolic and Transcriptomic Markers of Brain Injury in the Frontal Cortexes of NAFLD Pigs
Maj MA, Gehani TR, Immoos C, Medrano MS, Fanter RK, Strand CR, Glanz H, Piccolo BD, Abo-Ismail MK, La Frano MR, Manjarín R
Brain Sciences 2022
Alterations in Microbiota and Metabolites Related to Spontaneous Diabetes and Pre-Diabetes in Rhesus Macaques
Jiang C, Pan X, Luo J, Liu X, Zhang L, Liu Y, Lei G, Hu G, Li J
Genes & development 2022
Huangshan Maofeng Green Tea Extracts Prevent Obesity-Associated Metabolic Disorders by Maintaining Homeostasis of Gut Microbiota and Hepatic Lipid Classes in Leptin Receptor Knockout Rats
Wu G, Gu W, Cheng H, Guo H, Li D, Xie Z
Foods 2022
Response of circulating metabolites to an oral glucose challenge and risk of cardiovascular disease and mortality in the community
Gonzalez Izundegui D, Miller PE, Shah RV, Clish CB, Walker ME, Mitchell GF, Gerszten RE, Larson MG, Vasan RS, Nayor M
Cardiovascular Diabetology 2022
Sex-specific changes in triglyceride profiles in liver cirrhosis and hepatitis C virus infection.
Peschel G, Grimm J, Müller M, Höring M, Krautbauer S, Weigand K, Liebisch G, Buechler C
Lipids in Health and Disease 2022
A Six-Week Follow-Up Study on the Sustained Effects of Prolonged Water-Only Fasting and Refeeding on Markers of Cardiometabolic Risk.
Gabriel S, Ncube M, Zeiler E, Thompson N, Karlsen MC, Goldman DM, Glavas Z, Beauchesne A, Scharf E, Goldhamer AC, Myers TR
Nutrients 2022
The Beneficial Effect of Cinnamon and Red Capsicum Intake on Postprandial Changes in Plasma Metabolites Evoked by a High-Carbohydrate Meal in Men with Overweight/Obesity.
Hameed A, Adamska-Patruno E, Godzien J, Czajkowski P, Miksza U, Pietrowska K, Fiedorczuk J, Moroz M, Bauer W, Sieminska J, Górska M, Krętowski AJ, Ciborowski M
Nutrients 2022
Specific triacylglycerol, diacylglycerol, and lyso-phosphatidylcholine species for the prediction of type 2 diabetes: a ~ 16-year prospective study in Chinese.
Zhong J, Cheung CYY, Su X, Lee CH, Ru Y, Fong CHY, Liu Y, Cheung CKY, Lam KSL, Cai Z, Xu A
Cardiovascular Diabetology 2022
Application of Metabolomics in Childhood Leukemia Diagnostics.
Kozioł A, Pupek M
Archivum Immunologiae et Therapiae Experimentalis 2022
Plasma Lipidomic Subclasses and Risk of Hypertension in Middle-Aged and Elderly Chinese
Niu Z, Wu Q, Luo Y, Wang D, Zheng H, Wu Y, Yang X, Zeng R, Sun L, Lin X
2022
Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans
Chen ZZ, Pacheco JA, Gao Y, Deng S, Peterson B, Shi X, Zheng S, Tahir UA, Katz DH, Cruz DE, Ngo D, Benson MD, Robbins JM, Guo X, del Rocio Sevilla Gonzalez M, Manning A, Correa A, Meigs JB, Taylor KD, Rich SS, Goodarzi MO, Rotter JI, Wilson JG, Clish CB, Gerszten RE
Diabetes 2022
Metabolic and Genetic Markers Improve Prediction of Incident Type 2 Diabetes: A Nested Case-Control Study in Chinese
Liu J, Wang L, Qian Y, Shen Q, Yang M, Dong Y, Chen H, Yang Z, Liu Y, Cui X, Ma H, Jin G
The Journal of clinical endocrinology and metabolism 2022
Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts.
Goutman SA, Guo K, Savelieff MG, Patterson A, Sakowski SA, Habra H, Karnovsky A, Hur J, Feldman EL
Brain : a journal of neurology 2022
In Vitro Modeling of Diabetes Impact on Vascular Endothelium: Are Essentials Engaged to Tune Metabolism?
Vorotnikov AV, Khapchaev AY, Nickashin AV, Shirinsky VP
Biomedicines 2022
Gut Microbiota and Cardiovascular System: An Intricate Balance of Health and the Diseased State
Bhat MA, Mishra AK, Tantray JA, Alatawi HA, Saeed M, Rahman S, Jan AT
Life Sciences 2022
Metabolomics and Lipidomics Signatures of Insulin Resistance and Abdominal Fat Depots in People Living with Obesity.
Koay YC, Coster ACF, Chen DL, Milner B, Batarseh A, O'Sullivan JF, Greenfield JR, Samocha-Bonet D
Metabolites 2022
Change in fatty acid composition of plasma triglyceride caused by a 2 week comprehensive risk management for diabetes: A prospective observational study of type 2 diabetes patients with supercritical fluid chromatography/mass spectrometry‐based semi‐target lipidomic analysis
Taya N, Katakami N, Omori K, Hosoe S, Watanabe H, Takahara M, Miyashita K, Nishizawa H, Konya Y, Obara S, Hidaka A, Nakao M, Takahashi M, Izumi Y, Shimomura I, Bamba T
Journal of Diabetes Investigation 2022
Dairy Milk Casein and Whey Proteins Differentially Alter the Postprandial Lipidome in Persons with Prediabetes: A Comparative Lipidomics Study
Chen L, Xu R, McDonald JD, Bruno RS, Choueiry F, Zhu J
Journal of Agricultural and Food Chemistry 2022
Metabolic characterization of hypertrophic cardiomyopathy in human heart.
Wang W, Wang J, Yao K, Wang S, Nie M, Zhao Y, Wang B, Pang H, Xu J, Wu G, Lu M, Tang N, Qi C, Pei H, Luo X, Li D, Yang T, Sun Q, Wei X, Li Y, Jiang D, Li P, Song L, Hu Z
Nature cardiovascular research 2022
Proteomic Profiling Reveals Novel Biomarkers and Pathways in Type 2 Diabetes Risk
Debby Ngo, Mark D Benson, Jonathan Z. Long, Zsu-Zsu Chen, Ruiqi Wang, Anjali K Nath, Michelle J Keyes, Dongxiao Shen, Sumita Sinha, Eric Kuhn, Jordan Morningstar, Xu Shi, Bennet D. Peterson, Christopher Chan, Daniel H Katz, Usman A. Tahir, Laurie Farrell, Olle Melander, Jonathan D. Mosley, Steven A. Carr, Ramachandran Vasan, Martin G Larson, J. Gustav Smith, Thomas Wang, Qiong Yang, Robert Gerszten
JCI Insight 2021
Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions
NA Bihlmeyer, LC Kwee, CB Clish, AA Deik, RE Gerszten, NJ Pagidipati, B Laferrère, LP Svetkey, CB Newgard, WE Kraus, SH Shah, V Sánchez-Margalet
PloS one 2021
Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests
M Masoodi, A Gastaldelli, T Hyötyläinen, E Arretxe, C Alonso, M Gaggini, J Brosnan, QM Anstee, O Millet, P Ortiz, JM Mato, JF Dufour, M Orešič
Nature Reviews Gastroenterology & Hepatology 2021
Renin-angiotensin system inhibition reverses the altered triacylglycerol metabolic network in diabetic kidney disease
KM Sas, J Lin, CH Wang, H Zhang, J Saha, TM Rajendiran, T Soni, V Nair, F Eichinger, M Kretzler, FC Brosius, G Michailidis, S Pennathur
Metabolomics 2021
Possible Gender Influence in the Mechanisms Underlying the Oxidative Stress, Inflammatory Response, and the Metabolic Alterations in Patients with Obesity and/or Type 2 Diabetes
ML Contreras-Zentella, R Hernández-Muñoz
Antioxidants 2021
Identification of Circulating Endocan-1 and Ether Phospholipids as Biomarkers for Complications in Thalassemia Patients
A Botta, A Forest, C Daneault, K Pantopoulos, A Tantiworawit, A Phrommintikul, S Chattipakorn, N Chattipakorn, CD Rosiers, G Sweeney
Metabolites 2021
Plasma Lipidomic Profiles and Risk of Diabetes: 2 Prospective Cohorts of HIV-Infected and HIV-Uninfected Individuals
E Zhang, JC Chai, AA Deik, S Hua, A Sharma, MF Schneider, D Gustafson, DB Hanna, JE Lake, LH Rubin, WS Post, K Anastos, T Brown, CB Clish, RC Kaplan, Q Qi
The Journal of clinical endocrinology and metabolism 2021
Metabolomics Insights into Osteoporosis Through Association With Bone Mineral Density
X Zhang, H Xu, GH Li, MT Long, CL Cheung, RS Vasan, YH Hsu, DP Kiel, CT Liu
Journal of Bone and Mineral Research 2021
Overview of Lipidomic Analysis of Triglyceride Molecular Species in Biological Lipid Extracts
X Han, H Ye
Journal of Agricultural and Food Chemistry 2021
Clinical and metabolomic predictors of regression to normoglycemia in a population at intermediate cardiometabolic risk
M del Rocío Sevilla-González, J Merino, H Moreno-Macias, R Rojas-Martínez, DV Gómez-Velasco, AK Manning
Cardiovascular Diabetology 2021
Metabolic profile distinguishes laminitis-susceptible and -resistant ponies before and after feeding a high sugar diet
J Delarocque, DB Reiche, AD Meier, T Warnken, K Feige, MN Sillence
BMC veterinary research 2021
A prospective study of maternal adiposity and glycemic traits across pregnancy and mid-childhood metabolomic profiles
ML Rahman, M Doyon, M Arguin, P Perron, L Bouchard, MF Hivert
International Journal of Obesity 2021
Predictive utilities of lipid traits, lipoprotein subfractions and other risk factors for incident diabetes: a machine learning approach in the Diabetes Prevention Program
TV Varga, J Liu, RB Goldberg, G Chen, S Dagogo-Jack, C Lorenzo, KJ Mather, X Pi-Sunyer, S Brunak, M Temprosa
BMJ Open Diabetes Research & Care 2021
Lipids: biomarkers of healthy aging
I Almeida, S Magalhães, A Nunes
Biogerontology 2021
Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese
S Huo, L Sun, G Zong, X Shen, H Zheng, Q Jin, H Li, H Yin, X Lin
Nutrients 2021
Using lipid profiling to better characterize metabolic differences in apolipoprotein E (APOE) genotype among community-dwelling older Black men
MM Marron, SC Moore, SG Wendell, RM Boudreau, I Miljkovic, A Sekikawa, AB Newman
GeroScience 2021
Shorter Chain Triglycerides Are Negatively Associated with Symptom Improvement in Schizophrenia
A Tkachev, E Stekolshchikova, N Anikanov, S Zozulya, A Barkhatova, T Klyushnik, D Petrova
Biomolecules 2021
Plasma Metabolomic Signatures of Healthy Dietary Patterns in the Chronic Renal Insufficiency Cohort (CRIC) Study
H Kim, CA Anderson, EA Hu, Z Zheng, LJ Appel, J He, HI Feldman, AH Anderson, AC Ricardo, Z Bhat, TN Kelly, J Chen, RS Vasan, PL Kimmel, ME Grams, J Coresh, CB Clish, EP Rhee, CM Rebholz
The Journal of nutrition 2021
Metabolomics Signatures of Aging: Recent Advances
SS Adav, Y Wang
Aging and disease 2021
Differential Lipidomic Characteristics of Children Born to Women with Polycystic Ovary Syndrome
Z Zhang, Y Liu, J Lv, D Zhang, K Hu, J Li, J Ma, L Cui, H Zhao
Frontiers in Endocrinology 2021
In-depth triacylglycerol profiling using MS3 Q-Trap mass spectrometry
M Cabruja, J Priotti, P Domizi, K Papsdorf, DL Kroetz, A Brunet, K Contrepois, MP Snyder
Analytica Chimica Acta 2021
Prolactin and Risk of Epithelial Ovarian Cancer
CA Hathaway, MS Rice, MK Townsend, SE Hankinson, AA Arslan, JE Buring, G Hallmans, A Idahl, LD Kubzansky, IM Lee, EA Lundin, PM Sluss, A Zeleniuch-Jacquotte, SS Tworoger
Cancer epidemiology, biomarkers & prevention 2021
Emerging Applications of Metabolomics to Assess the Efficacy of Traditional Chinese Medicines for Treating Type 2 Diabetes Mellitus
Y Zhang, Y Yang, L Ding, Z Wang, Y Xiao, W Xiao
Frontiers in pharmacology 2021
Mouse lipidomics reveals inherent flexibility of a mammalian lipidome
MA Surma, MJ Gerl, R Herzog, J Helppi, K Simons, C Klose
Scientific Reports 2021
Intensive lactation among women with recent gestational diabetes significantly alters the early postpartum circulating lipid profile: the SWIFT study
Z Zhang, M Lai, AL Piro, SE Alexeeff, A Allalou, HL Röst, FF Dai, MB Wheeler, EP Gunderson
BMC Medicine 2021
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study
RC Slieker, LA Donnelly, H Fitipaldi, GA Bouland, GN Giordano, M Åkerlund, MJ Gerl, E Ahlqvist, A Ali, I Dragan, P Elders, A Festa, MK Hansen, AA van der Heijden, DM Aly, M Kim, D Kuznetsov, F Mehl, C Klose, K Simons, I Pavo, TJ Pullen, T Suvitaival, A Wretlind, P Rossing, V Lyssenko, CL Quigley, L Groop, B Thorens, PW Franks, M Ibberson, GA Rutter, JW Beulens, LM t Hart, ER Pearson
Diabetes 2021
Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity
T Cao, J Zhao, X Hong, G Wang, FB Hu, X Wang, L Liang
Metabolites 2021
Genomics of Postprandial Lipidomics in the Genetics of Lipid-Lowering Drugs and Diet Network Study
MR Irvin, ME Montasser, T Kind, S Fan, DK Barupal, A Patki, RM Tanner, ND Armstrong, KA Ryan, SA Claas, JR OConnell, HK Tiwari, DK Arnett
Nutrients 2021
Fatty acids and their role in type‑2 diabetes (Review)
S Shetty, S Kumari
Experimental and therapeutic medicine 2021
Plasma lipidomics profile in pregnancy and gestational diabetes risk: a prospective study in a multiracial/ethnic cohort
ML Rahman, YC Feng, O Fiehn, PS Albert, MY Tsai, Y Zhu, X Wang, F Tekola-Ayele, L Liang, C Zhang
BMJ Open Diabetes Research & Care 2021
Longitudinal Plasma Lipidome and Risk of Type 2 Diabetes in a Large Sample of American Indians With Normal Fasting Glucose: The Strong Heart Family Study
G Miao, Y Zhang, Z Huo, W Zeng, J Zhu, JG Umans, G Wohlgemuth, D Pedrosa, B DeFelice, SA Cole, AM Fretts, ET Lee, BV Howard, O Fiehn, J Zhao
Diabetes care 2021
Plasma Metabolomics and Lipidomics Differentiate Obese Individuals by Peripheral Neuropathy Status
K Guo, M Savelieff, A Rumora, F Alakwaa, B Callaghan, J Hur, E Feldman
The Journal of clinical endocrinology and metabolism 2021
Revealing the Hypoglycemic Effects and Mechanism of GABA-Rich Germinated Adzuki Beans on T2DM Mice by Untargeted Serum Metabolomics
X Jiang, Q Xu, A Zhang, Y Liu, Z Li, H Tang, D Cao, D Zhang
Frontiers in Nutrition 2021
Lipidomics Reveals Serum Specific Lipid Alterations in Diabetic Nephropathy
Xu T, Xu X, Zhang L, Zhang K, Wei Q, Zhu L, Yu Y, Xiao L, Lin L, Qian W, Wang J, Ke M, An X, Liu S
Frontiers in Endocrinology 2021
Distinct Lipidomic Signatures in People Living With HIV: Combined Analysis of ACTG 5260s and MACS/WIHS
Jao J, Balmert LC, Sun S, McComsey GA, Brown TT, Tien PC, Currier JS, Stein JH, Qiu Y, LeRoith D, Kurland IJ
The Journal of clinical endocrinology and metabolism 2021
Changes in metabolomics profiles over ten years and subsequent risk of developing type 2 diabetes: Results from the Nurses' Health Study
Wittenbecher C, Guasch-Ferré M, Haslam DE, Dennis C, Li J, Bhupathiraju SN, Lee CH, Qi Q, Liang L, Eliassen AH, Clish C, Sun Q, Hu FB
EBioMedicine 2021
Human disease biomarker panels through systems biology
Smith BJ, Silva-Costa LC, Martins-de-Souza D
Biophysical Reviews 2021
Comparative Analysis of the Effects of Fish Oil and Fenofibrate on Plasma Metabolomic Profiles in Overweight and Obese Individuals
Michielsen CC, Hangelbroek RW, Bragt MC, Verheij ER, Wopereis S, Mensink RP, Afman LA
Molecular Nutrition & Food Research 2021
Insights into genetic variants associated with NASH-fibrosis from metabolite profiling
JP Mann, M Pietzner, LB Wittemans, ED Rolfe, ND Kerrison, F Imamura, NG Forouhi, E Fauman, ME Allison, JL Griffin, A Koulman, NJ Wareham, C Langenberg
Human Molecular Genetics 2020
Sphingolipid Mediators of Myocardial Pathology
A Kovilakath, LA Cowart
Journal of Lipid and Atherosclerosis 2020
Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community
M Nayor, RV Shah, PE Miller, JB Blodgett, M Tanguay, AR Pico, VL Murthy, R Malhotra, NE Houstis, A Deik, KA Pierce, K Bullock, L Dailey, RS Velagaleti, SA Moore, JE Ho, AL Baggish, CB Clish, MG Larson, RS Vasan, GD Lewis
Circulation 2020
Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications
P Sangwung, KF Petersen, GI Shulman, JW Knowles
Endocrinology 2020

Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico


K Gonzalez-Aldaco, S Roman, LA Torres-Reyes, A Panduro
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020
Regulatory Connections between Iron and Glucose Metabolism
C Fillebeen, NH Lam, S Chow, A Botta, G Sweeney, K Pantopoulos
International journal of molecular sciences 2020
Dairy Intake in 2 American Adult Cohorts Associates with Novel and Known Targeted and Nontargeted Circulating Metabolites
A Hruby, C Dennis, PF Jacques
The Journal of nutrition 2020
Lipidomic profiling identifies signatures of metabolic risk
X Yin, CM Willinger, J Keefe, J Liu, A Fernández-Ortiz, B Ibáñez, J Peñalvo, A Adourian, G Chen, D Corella, R Pamplona, M Portero-Otin, M Jove, P Courchesne, CM van Duijn, V Fuster, JM Ordovás, A Demirkan, MG Larson, D Levy
EBioMedicine 2020
Metabolites Associated with Walking Ability Among the Oldest Old from the CHS All Stars Study
MM Marron, SG Wendell, RM Boudreau, CB Clish, AJ Santanasto, GC Tseng, JM Zmuda, AB Newman, D Melzer
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2020
Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna
JK Constantinou, AD Southam, J Kvist, MR Jones, MR Viant, L Mirbahai
Scientific Reports 2020
Lifetime Average Cannabis Use in Relation to Hypertriglyceridemic Waist Phenotype in U.S. Adults: A Population-Based Cross-Sectional Study
G Ngueta
Cannabis and Cannabinoid Research 2020
The Gut Microbial Diversity of Newly Diagnosed Diabetics but Not of Prediabetics Is Significantly Different from That of Healthy Nondiabetics
AH Gaike, D Paul, S Bhute, DP Dhotre, P Pande, S Upadhyaya, Y Reddy, R Sampath, D Ghosh, D Chandraprabha, J Acharya, G Banerjee, VP Sinkar, SS Ghaskadbi, YS Shouche, KL Whiteson
mSystems 2020
Serum sphingolipids and incident diabetes in a US population with high diabetes burden: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
GC Chen, JC Chai, B Yu, GA Michelotti, ML Grove, AM Fretts, ML Daviglus, OL Garcia-Bedoya, B Thyagarajan, N Schneiderman, J Cai, RC Kaplan, E Boerwinkle, Q Qi
The American journal of clinical nutrition 2020
Metabolic characterisation of disturbances in the APOC3/triglyceride-rich lipoprotein pathway through sample-based recall by genotype
LJ Corbin, DA Hughes, AJ Chetwynd, AE Taylor, AD Southam, A Jankevics, RJ Weber, A Groom, WB Dunn, NJ Timpson
Metabolomics 2020
Metabolic signatures associated with Western and Prudent dietary patterns in women
PD Chandler, R Balasubramanian, N Paynter, F Giulianini, T Fung, LF Tinker, L Snetselaar, S Liu, C Eaton, DK Tobias, FK Tabung, JA Manson, EL Giovannucci, C Clish, KM Rexrode
The American journal of clinical nutrition 2020
Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study
ME Walker, RJ Song, X Xu, RE Gerszten, D Ngo, CB Clish, L Corlin, J Ma, V Xanthakis, PF Jacques, RS Vasan
Nutrients 2020
A lipidome-wide association study of the lipoprotein insulin resistance index
M Bagheri, HK Tiwari, AL Murillo, R Al-Tobasei, DK Arnett, T Kind, DK Barupal, S Fan, O Fiehn, J Oconnell, M Montasser, S Aslibekyan, MR Irvin
Lipids in Health and Disease 2020
Review of methods for detecting glycemic disorders
M Bergman, M Abdul-Ghani, RA DeFronzo, M Manco, G Sesti, TV Fiorentino, A Ceriello, M Rhee, LS Phillips, S Chung, C Cravalho, R Jagannathan, L Monnier, C Colette, D Owens, C Bianchi, S del Prato, MP Monteiro, JS Neves, JL Medina, MP Macedo, RT Ribeiro, JF Raposo, B Dorcely, N Ibrahim, M Buysschaert
Diabetes Research and Clinical Practice 2020
Altered Metabolome of Lipids and Amino Acids Species: A Source of Early Signature Biomarkers of T2DM
A Hameed, P Mojsak, A Buczynska, HA Suleria, A Kretowski, M Ciborowski
Journal of Clinical Medicine 2020
Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes
M Lai, DA Rijjal, HL Röst, FF Dai, EP Gunderson, MB Wheeler
eLife 2020
Associations of depression status with plasma levels of candidate lipid and amino acid metabolites: a meta-analysis of individual data from three independent samples of US postmenopausal women
T Huang, R Balasubramanian, Y Yao, CB Clish, AH Shadyab, B Liu, SS Tworoger, KM Rexrode, JA Manson, LD Kubzansky, SE Hankinson
Molecular Psychiatry 2020
Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress
JA Beckman, JR Hu, S Huang, E Farber-Eger, QS Wells, TJ Wang, RE Gerszten, JF Ferguson
Clinical Science 2020
Metabolomic signatures of cardiac remodelling and heart failure risk in the community
C Andersson, C Liu, S Cheng, TJ Wang, RE Gerszten, MG Larson, RS Vasan
ESC Heart Failure 2020
The metabolic footprint of compromised insulin sensitivity under fasting and hyperinsulinemic-euglycemic clamp conditions in an Arab population
A Halama, NN Suleiman, M Kulinski, I Bettahi, S Hassoun, M Alkasem, I Abdalhakam, A Iskandarani, TA Samra, SL Atkin, K Suhre, AB Abou-Samra
Scientific Reports 2020
Postpartum plasma metabolomic profile among women with preeclampsia and preterm delivery: implications for long-term health
X Hong, B Zhang, L Liang, Y Zhang, Y Ji, G Wang, H Ji, CB Clish, I Burd, C Pearson, B Zuckerman, FB Hu, X Wang
BMC Medicine 2020
Label-free CARS microscopy reveals similar triacylglycerol acyl chain length and saturation in myocellular lipid droplets of athletes and individuals with type 2 diabetes
S Daemen, A Gemmink, A Paul, N Billecke, K Rieger, SH Parekh, MK Hesselink
Diabetologia 2020
A lipid-related metabolomic pattern of diet quality
M Bagheri, W Willett, MK Townsend, P Kraft, KL Ivey, EB Rimm, KM Wilson, KH Costenbader, EW Karlson, EM Poole, OA Zeleznik, AH Eliassen
The American journal of clinical nutrition 2020
Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis
S Lamichhane, AM Dickens, P Sen, H Laurikainen, F Borgan, J Suvisaari, T Hyötyläinen, O Howes, J Hietala, M Orešič
Schizophrenia Bulletin 2020
The impact of ageing on lipid-mediated regulation of adult stem cell behavior and tissue homeostasis
RS Demarco, M Clémot, DL Jones
Mechanisms of Ageing and Development 2020
Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH
GV Hernandez, VA Smith, M Melnyk, MA Burd, KA Sprayberry, MS Edwards, DG Peterson, DC Bennet, RK Fanter, DA Columbus, JP Steibel, H Glanz, C Immoos, MS Rice, TM Santiago-Rodriguez, J Blank, JJ VanderKelen, CL Kitts, BD Piccolo, MR Frano, DG Burrin, Magdalena, R Manjarin
AJP Gastrointestinal and Liver Physiology 2020
Lipidomics investigations into the tissue phospholipidomic landscape of invasive ductal carcinoma of the breast
Taware R, More TH, Bagadi M, Taunk K, Mane A, Rapole S
RSC Advances 2020
Metabolomics and Proteomics in Type 2 Diabetes.
Chen ZZ, Gerszten RE
Circulation research 2020
SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and independent mechanisms
Soravis Osataphan, Chiara Macchi, Garima Singhal, Jeremy Chimene-Weiss, Vicencia M. Sales, Chisayo Kozuka, Hui Pan, Yanin Tangjaroenpaisan, Jordan E. Morningstar, Jonathan M Dreyfuss, Robert E. Gerszten, Mary Elizabeth Patti
JCI Insight 2019
High protein feeding induces de novo lipogenesis in healthy humans
Evelina Charidemou, Tom Ashmore, Xuefei Li, Ben D McNally, James West, Sonia Liggi, Matthew Harvey, Elise R Orford, Julian L. Griffin
JCI Insight 2019
Increased lipogenesis and impaired beta-oxidation predict type 2 diabetic kidney disease progression in American Indians
Farsad Afshinnia, Viji Nair, Jiahe Lin, Thekkelnaycke Rajendiran, Tanu Soni, Jaeman Byun, Kumar Sharma, Patrice Fort, Thomas Gardner, Helen C. Looker, Robert Nelson, Frank C. Brosius, Eva L. Feldman, George Michailidis, Matthias Kretzler, Subramaniam Pennathur
JCI Insight 2019
Roux-en-Y gastric bypass surgery reprograms enterocyte triglyceride metabolism and postprandial secretion in rats
S Kaufman, M Arnold, AA Diaz, H Neubauer, S Wolfrum, H Köfeler, W Langhans, JP Krieger
Molecular Metabolism 2019
Sex, gut microbiome, and cardiovascular disease risk
AC Razavi, KS Potts, TN Kelly, LA Bazzano
Biology of sex differences 2019

Detection of Secondary Metabolites as Biomarkers for the Early Diagnosis and Prevention of Type 2 Diabetes


JY Al-Aama, HB Mahdi, MA Salama, KH Bakur, A Alhozali, HH Mosli, SM Bahijri, A Bahieldin, L Willmitzer, S Edris
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019
Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation
P He, B Hou, Y Li, C Xu, P Ma, SM Lam, V Gil, X Yang, X Yang, L Zhang, G Shui, J Song, G Qiang, CW Liew, G Du
Biomolecules 2019
Cold-induced lipid dynamics and transcriptional programs in white adipose tissue
Z Xu, W You, Y Zhou, W Chen, Y Wang, T Shan
BMC Biology 2019
Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling
W Kim, A Deik, C Gonzalez, ME Gonzalez, F Fu, M Ferrari, CL Churchhouse, JC Florez, SB Jacobs, CB Clish, EP Rhee
Cell Metabolism 2019
Plasma metabolites predict both insulin resistance and incident type 2 diabetes: a metabolomics approach within the Prevención con Dieta Mediterránea (PREDIMED) study
C Papandreou, M Bulló, M Ruiz-Canela, C Dennis, A Deik, D Wang, M Guasch-Ferré, E Yu, C Razquin, D Corella, R Estruch, E Ros, M Fitó, M Fiol, L Liang, P Hernández-Alonso, CB Clish, MA Martínez-González, FB Hu, J Salas-Salvadó
The American journal of clinical nutrition 2019
Repeated administration of the NSAID meloxicam alters the plasma and urine lipidome
SM Rivera-Velez, LE Broughton-Neiswanger, M Suarez, P Piñeyro, J Navas, S Chen, J Hwang, NF Villarino
Scientific Reports 2019
Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection
E Bowman, NT Funderburg
Current HIV/AIDS Reports 2019
A Slow-Digesting Carbohydrate Diet during Rat Pregnancy Protects Offspring from Non-Alcoholic Fatty Liver Disease Risk through the Modulation of the Carbohydrate-Response Element and Sterol Regulatory Element Binding Proteins
R Salto, M Manzano, MD Girón, A Cano, A Castro, JD Vílchez, E Cabrera, JM López-Pedrosa
Nutrients 2019
Maternal triacylglycerol signature and risk of food allergy in offspring
X Hong, L Liang, Q Sun, CA Keet, HJ Tsai, Y Ji, G Wang, H Ji, C Clish, C Pearson, Y Wang, RA Wood, FB Hu, X Wang
Journal of Allergy and Clinical Immunology 2019
Metabolomics of Type 1 and Type 2 Diabetes
B Arneth, R Arneth, M Shams
International journal of molecular sciences 2019
Circulating Saturated Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis
Huang, Lin, Aris, Yang, Chen, Li
Nutrients 2019
New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism
S Eid, KM Sas, SF Abcouwer, EL Feldman, TW Gardner, S Pennathur, PE Fort
Diabetologia 2019

Serum untargeted lipidomic profiling reveals dysfunction of phospholipid metabolism in subclinical coronary artery disease


D Djekic, R Pinto, D Repsilber, T Hyotylainen, M Henein
Vascular Health and Risk Management 2019
Identifying Metabolomic Profiles of Insulinemic Dietary Patterns
FK Tabung, R Balasubramanian, L Liang, SK Clinton, EM Feliciano, JA Manson, LV Horn, J Wactawski-Wende, CB Clish, EL Giovannucci, KM Rexrode
Metabolites 2019
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
R Tabassum, JT Rämö, P Ripatti, JT Koskela, M Kurki, J Karjalainen, P Palta, S Hassan, J Nunez-Fontarnau, TT Kiiskinen, S Söderlund, N Matikainen, MJ Gerl, MA Surma, C Klose, NO Stitziel, H Laivuori, AS Havulinna, SK Service, V Salomaa, M Pirinen, M Jauhiainen, MJ Daly, NB Freimer, A Palotie, MR Taskinen, K Simons, S Ripatti
Nature Communications 2019
Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain
N Geidenstam, YH Hsu, CM Astley, JM Mercader, M Ridderstråle, ME Gonzalez, C Gonzalez, JN Hirschhorn, RM Salem, RD Clugston
PloS one 2019
Metabolome-Wide Association Study of the Relationship Between Habitual Physical Activity and Plasma Metabolite Levels
M Ding, OA Zeleznik, M Guasch-Ferre, J Hu, J Lasky-Su, IM Lee, RD Jackson, AH Shadyab, MJ LaMonte, C Clish, AH Eliassen, F Sacks, WC Willett, FB Hu, KM Rexrode, P Kraft
American Journal of Epidemiology 2019
Plasma metabolites associated with homeostatic model assessment of insulin resistance: metabolite-model design and external validation
P Hernández-Alonso, J García-Gavilán, L Camacho-Barcia, A Sjödin, TT Hansen, J Harrold, J Salas-Salvadó, JC Halford, S Canudas, M Bulló
Scientific Reports 2019
n-3 PUFA and caloric restriction diet alters lipidomic profiles in obese men with metabolic syndrome: a preliminary open study
A Shabrina, TH Tung, NT Nguyen, HC Lee, HT Wu, W Wang, SY Huang
European Journal of Nutrition 2019
Identifying metabolomic profiles of inflammatory diets in postmenopausal women
FK Tabung, L Liang, T Huang, R Balasubramanian, Y Zhao, PD Chandler, JA Manson, EM Feliciano, KM Hayden, LV Horn, CB Clish, EL Giovannucci, KM Rexrode
Clinical nutrition (Edinburgh, Scotland) 2019
Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy
S Furse, SL White, CL Meek, B Jenkins, CJ Petry, MC Vieira, SE Ozanne, DB Dunger, L Poston, A Koulman
2019
Identification of 102 Correlations between Serum Metabolites and Habitual Diet in a Metabolomics Study of the Prostate, Lung, Colorectal, and Ovarian Cancer Trial
KM Mazzilli, KM McClain, L Lipworth, MC Playdon, JN Sampson, CB Clish, RE Gerszten, ND Freedman, SC Moore
The Journal of nutrition 2019
Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program
ZZ Chen, J Liu, J Morningstar, BM Heckman-Stoddard, CG Lee, S Dagogo-Jack, JF Ferguson, RF Hamman, WC Knowler, KJ Mather, L Perreault, JC Florez, TJ Wang, C Clish, M Temprosa, RE Gerszten
Diabetes 2019
Lipidomics as a tool of predicting progression from non-alcoholic fatty pancreas disease to type 2 diabetes mellitus
Lin M, Weng SY, Chai KF, Mao ZJ
RSC Advances 2019
Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities
Marta Christov, Abbe Clark, Braden Corbin, Samy Hakroush, Eugene Rhee, Hiroaki Saito, Daniel Brooks, Eric Hesse, Mary Bouxsein, Niels Galjart, Ji Yong Jung, Peter Mundel, Harald Jüppner, Astrid Weins, Anna Greka
JCI Insight 2018
The circulating metabolome of human starvation
Matthew Steinhauser, Benjamin Olenchock, John O'Keefe, Mingyue Lun, Kerry Pierce, Hang Lee, Lorena Pantano, Anne Klibanski, Gerald I. Shulman, Clary Clish, Pouneh Fazeli
JCI Insight 2018
Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites
S Fujisaka, J Avila-Pacheco, M Soto, A Kostic, JM Dreyfuss, H Pan, S Ussar, E Altindis, N Li, L Bry, CB Clish, CR Kahn
Cell Reports 2018
Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption
FW Sanders, A Acharjee, C Walker, L Marney, LD Roberts, F Imamura, B Jenkins, J Case, S Ray, S Virtue, A Vidal-Puig, D Kuh, R Hardy, M Allison, N Forouhi, AJ Murray, N Wareham, M Vacca, A Koulman, JL Griffin
Genome biology 2018
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome
A Lovric, M Granér, E Bjornson, M Arif, R Benfeitas, K Nyman, M Ståhlman, MO Pentikäinen, J Lundbom, A Hakkarainen, R Sirén, MS Nieminen, N Lundbom, K Lauerma, MR Taskinen, A Mardinoglu, J Boren
Scientific Reports 2018
Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study
C Razquin, L Liang, E Toledo, CB Clish, M Ruiz-Canela, Y Zheng, DD Wang, D Corella, O Castaner, E Ros, F Aros, E Gomez-Gracia, M Fiol, JM Santos-Lozano, M Guasch-Ferre, L Serra-Majem, A Sala-Vila, P Buil-Cosiales, M Bullo, M Fito, O Portoles, R Estruch, J Salas-Salvado, FB Hu, MA Martinez-Gonzalez
International Journal of Cardiology 2018
Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose
J Merino, A Leong, CT Liu, B Porneala, GA Walford, M Grotthuss, TJ Wang, J Flannick, J Dupuis, D Levy, RE Gerszten, JC Florez, JB Meigs
Diabetologia 2018
Development of A High Coverage Pseudotargeted Lipidomics Method Based on Ultra-High Performance Liquid Chromatography-Mass Spectrometry
Q Xuan, C Hu, D Yu, L Wang, Y Zhou, X Zhao, Q Li, X Hou, G Xu
Analytical Chemistry 2018
Metabolomics Identifies Distinctive Metabolite Signatures for Measures of Glucose Homeostasis: The Insulin Resistance Atherosclerosis Family Study (IRAS-FS)
ND Palmer, H Okut, FC Hsu, MC Ng, YD Chen, MO Goodarzi, KD Taylor, JM Norris, C Lorenzo, JI Rotter, RN Bergman, CD Langefeld, LE Wagenknecht, DW Bowden
The Journal of clinical endocrinology and metabolism 2018
Metabolomics signatures associated with an oral glucose challenge in pregnant women
B Gelaye, CB Clish, M Denis, G Larrabure, MG Tadesse, A Deik, K Pierce, K Bullock, C Dennis, DA Enquobahrie, MA Williams
Diabetes & Metabolism 2018
Lipidomics and Biomarker Discovery in Kidney Disease
F Afshinnia, TM Rajendiran, S Wernisch, T Soni, A Jadoon, A Karnovsky, G Michailidis, S Pennathur
Seminars in Nephrology 2018
Prioritising Risk Factors for Type 2 Diabetes: Causal Inference through Genetic Approaches
LB Wittemans, LA Lotta, C Langenberg
Current Diabetes Reports 2018
MicroRNA, Proteins, and Metabolites as Novel Biomarkers for Prediabetes, Diabetes, and Related Complications
S Vaishya, RD Sarwade, V Seshadri
Frontiers in Endocrinology 2018
Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women
N Kawanishi, Y Kato, K Yokozeki, S Sawada, R Sakurai, Y Fujiwara, S Shinkai, N Goda, K Suzuki
Lipids in Health and Disease 2018
Redefining environmental exposure for disease etiology
SM Rappaport
npj Systems Biology and Applications 2018
Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes
LW Johnston, Z Liu, R Retnakaran, B Zinman, A Giacca, SB Harris, RP Bazinet, AJ Hanley
Journal of lipid research 2018
Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study
CJ Petry, A Koulman, L Lu, B Jenkins, S Furse, P Prentice, L Matthews, IA Hughes, CL Acerini, KK Ong, DB Dunger
Reproductive Biology and Endocrinology 2018
Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes
P Jha, MT McDevitt, E Halilbasic, EG Williams, PM Quiros, K Gariani, MB Sleiman, R Gupta, A Ulbrich, A Jochem, JJ Coon, M Trauner, DJ Pagliarini, J Auwerx
Cell Systems 2018
Targeted lipidomics analysis identified altered serum lipid profiles in patients with polymyositis and dermatomyositis
J Raouf, H Idborg, P Englund, H Alexanderson, M Dastmalchi, PJ Jakobsson, IE Lundberg, M Korotkova
Arthritis Research & Therapy 2018
Targeted Metabolomics to Understand the Association between Arsenic Metabolism and Diabetes-Related Outcomes: Preliminary Evidence from the Strong Heart Family Study
MJ Spratlen, M Grau-Perez, JG Umans, J Yracheta, LG Best, K Francesconi, W Goessler, T Bottiglieri, MV Gamble, SA Cole, J Zhao, A Navas-Acien
Environmental Research 2018
Habitual sleep quality, plasma metabolites and risk of coronary heart disease in post-menopausal women
T Huang, OA Zeleznik, EM Poole, CB Clish, AA Deik, JM Scott, C Vetter, ES Schernhammer, R Brunner, L Hale, JA Manson, FB Hu, S Redline, SS Tworoger, KM Rexrode
International Journal of Epidemiology 2018
The relationship between phospholipids and insulin resistance: From clinical to experimental studies
W Chang, GM Hatch, Y Wang, F Yu, M Wang
Journal of Cellular and Molecular Medicine 2018
Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial
C Razquin, E Toledo, CB Clish, M Ruiz-Canela, C Dennis, D Corella, C Papandreou, E Ros, R Estruch, M Guasch-Ferré, E Gómez-Gracia, M Fitó, E Yu, J Lapetra, D Wang, D Romaguera, L Liang, A Alonso-Gómez, A Deik, M Bullo, L Serra-Majem, J Salas-Salvadó, FB Hu, MA Martínez-González
Diabetes care 2018
Variability of Two Metabolomic Platforms in CKD
EP Rhee, SS Waikar, CM Rebholz, Z Zheng, R Perichon, CB Clish, AM Evans, J Avila, MR Denburg, AH Anderson, RS Vasan, HI Feldman, PL Kimmel, J Coresh
Clinical journal of the American Society of Nephrology : CJASN 2018
Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial
Papandreou C, Bulló M, Zheng Y, Ruiz-Canela M, Yu E, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Lapetra J, Serra-Majem L, Gómez-Gracia E, Liang L, Fragkiadakis GA, Razquin C, Hu FB, Salas-Salvadó J
The American journal of clinical nutrition 2018
Metabolomics and Metabolic Diseases: Where Do We Stand?
CB Newgard
Cell Metabolism 2017
The ins and outs of endoplasmic reticulum‐controlled lipid biosynthesis
J Jacquemyn, A Cascalho, RE Goodchild
EMBO reports 2017
Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease
M Friesen, R Camahort, YK Lee, F Xia, RE Gerszten, EP Rhee, RC Deo, CA Cowan
Stem Cell Reports 2017
Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport
A Vijayakumar, P Aryal, J Wen, I Syed, RP Vazirani, PM Moraes-Vieira, JP Camporez, MR Gallop, RJ Perry, OD Peroni, GI Shulman, A Saghatelian, TE McGraw, BB Kahn
Cell Reports 2017
Comparing identified and statistically significant lipids and polar metabolites in 15-year old serum and dried blood spot samples for longitudinal studies: Comparing lipids and metabolites in serum and DBS samples
JE Kyle, CP Casey, KG Stratton, EM Zink, YM Kim, X Zheng, ME Monroe, KK Weitz, KJ Bloodsworth, DJ Orton, YM Ibrahim, RJ Moore, CG Lee, C Pedersen, E Orwoll, RD Smith, KE Burnum-Johnson, ES Baker
Rapid communications in mass spectrometry : RCM 2017
Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism
L Stechemesser, SK Eder, A Wagner, W Patsch, A Feldman, M Strasser, S Auer, D Niederseer, U Huber-Schönauer, B Paulweber, S Zandanell, S Ruhaltinger, D Weghuber, E Haschke-Becher, C Grabmer, E Rohde, C Datz, TK Felder, E Aigner
Molecular Metabolism 2017
Metabolites Associated With Lean Mass and Adiposity in Older Black Men
RA Murphy, SC Moore, M Playdon, O Meirelles, AB Newman, I Milijkovic, SB Kritchevsky, A Schwartz, BH Goodpaster, J Sampson, P Cawthon, EM Simonsick, RE Gerszten, CB Clish, TB Harris
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2017
HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus
DN Fusco, H Pratt, S Kandilas, SS Cheon, W Lin, DA Cronkite, M Basavappa, KL Jeffrey, A Anselmo, R Sadreyev, C Yapp, X Shi, JF O'Sullivan, RE Gerszten, T Tomaru, S Yoshino, T Satoh, RT Chung
Frontiers in microbiology 2017
Form(ul)ation of adipocytes by lipids
K Lapid, JM Graff
Adipocyte 2017
Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance
KI Olmstead, MR la Frano, J Fahrmann, D Grapov, JA Viscarra, JW Newman, O Fiehn, DE Crocker, FV Filipp, RM Ortiz
Metabolomics 2017
Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study
V Chouraki, SR Preis, Q Yang, A Beiser, S Li, MG Larson, G Weinstein, TJ Wang, RE Gerszten, RS Vasan, S Seshadri
Alzheimer's and Dementia 2017
A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles
FC Pinto, S Ravipati, DA Barrett, TC Hodgman
Metabolomics 2017
Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity
AC Alves, B Valcarcel, VP Mäkinen, L Morin-Papunen, S Sebert, AJ Kangas, P Soininen, S Das, MD Iorio, L Coin, M Ala-Korpela, MR Järvelin, S Franks
International Journal of Obesity 2017
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
V Rusu, E Hoch, JM Mercader, DE Tenen, M Gymrek, CR Hartigan, M DeRan, M Grotthuss, P Fontanillas, A Spooner, G Guzman, AA Deik, KA Pierce, C Dennis, CB Clish, SA Carr, BK Wagner, M Schenone, MC Ng, BH Chen, F Centeno-Cruz, C Zerrweck, L Orozco, DM Altshuler, SL Schreiber, JC Florez, SB Jacobs, ES Lander, MC Ng, D Shriner, BH Chen, J Li, WM Chen, X Guo, J Liu, SJ Bielinski, LR Yanek, MA Nalls, ME Comeau, LJ Rasmussen-Torvik, RA Jensen, DS Evans, YV Sun, P An, SR Patel, Y Lu, J Long, LL Armstrong, L Wagenknecht, L Yang, BM Snively, ND Palmer, P Mudgal, CD Langefeld, KL Keene, BI Freedman, JC Mychaleckyj, U Nayak, LJ Raffel, MO Goodarzi, YD Chen, HA Taylor, A Correa, M Sims, D Couper, JS Pankow, E Boerwinkle, A Adeyemo, A Doumatey, G Chen, RA Mathias, D Vaidya, AB Singleton, AB Zonderman, RP Igo, JR Sedor, EK Kabagambe, DS Siscovick, B McKnight, K Rice, Y Liu, WC Hsueh, W Zhao, LF Bielak, A Kraja, MA Province, EP Bottinger, O Gottesman, Q Cai, W Zheng, WJ Blot, WL Lowe, JA Pacheco, DC Crawford, E Grundberg, SS Rich, MG Hayes, XO Shu, RJ Loos, IB Borecki, PA Peyser, SR Cummings, BM Psaty, M Fornage, SK Iyengar, MK Evans, DM Becker, WH Kao, JG Wilson, JI Rotter, MM Sale, S Liu, CN Rotimi, DW Bowden, JM Mercader, A Huerta-Chagoya, H García-Ortiz, H Moreno-Macías, A Manning, L Caulkins, NP Burtt, J Flannick, N Patterson, CA Aguilar-Salinas, T Tusié-Luna, D Altshuler, JC Florez, A Martínez-Hernández, F Centeno-Cruz, FM Barajas-Olmos, C Zerrweck, C Contreras-Cubas, E Mendoza-Caamal, C Revilla-Monsalve, S Islas-Andrade, E Córdova, X Soberón, L Orozco, C González-Villalpando, ME González-Villalpando, CA Haiman, L Wilkens, LL Marchand, K Monroe, L Kolonel, O Arellano-Campos, ML Ordóñez-Sánchez, M Rodríguez-Torres, Y Segura-Kato, R Rodríguez-Guillén, I Cruz-Bautista, LL Muñoz-Hernandez, T Sáenz, D Gómez, U Alvirde, P Almeda-Valdés, ML Cortes
Cell 2017
Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy
NF Delaney, R Sharma, L Tadvalkar, CB Clish, RG Haller, VK Mootha
Proceedings of the National Academy of Sciences 2017
Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B
R Yang, C Hu, W Sun, Q Pan, F Shen, Z Yang, Q Su, G Xu, J Fan
Scientific Reports 2017
Early gestational maternal low-protein diet diminishes hepatic response to fasting in young adult male mice
N Sato, K Sudo, M Mori, C Imai, M Muramatsu, M Sugimoto
Scientific Reports 2017
Metabolomics of Diabetic Retinopathy
G Liew, Z Lei, G Tan, N Joachim, IV Ho, TY Wong, P Mitchell, B Gopinath, B Crossett
Current Diabetes Reports 2017
A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study
F Imamura, SJ Sharp, A Koulman, MB Schulze, J Kröger, JL Griffin, JM Huerta, M Guevara, I Sluijs, A Agudo, E Ardanaz, B Balkau, H Boeing, V Chajes, CC Dahm, C Dow, G Fagherazzi, EJ Feskens, PW Franks, D Gavrila, M Gunter, R Kaaks, TJ Key, KT Khaw, T Kühn, O Melander, E Molina-Portillo, PM Nilsson, A Olsen, K Overvad, D Palli, S Panico, O Rolandsson, S Sieri, C Sacerdote, N Slimani, AM Spijkerman, A Tjønneland, R Tumino, YT van der Schouw, C Langenberg, E Riboli, NG Forouhi, NJ Wareham, RC Ma
PLoS Medicine 2017
Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge
S Wopereis, JH Stroeve, A Stafleu, GC Bakker, J Burggraaf, MJ van Erk, L Pellis, R Boessen, AA Kardinaal, B Ommen
Genes & Nutrition 2017
Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet
Estefanía Toledo, Dong D Wang, Miguel Ruiz-Canela, Clary B Clish, Cristina Razquin, Yan Zheng, Marta Guasch-Ferré, Adela Hruby, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, Emilio Ros, José Lapetra, Montserrat Fito, Fernando Aros, Luis Serra-Majem, Liming Liang, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
The American journal of clinical nutrition 2017
Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea)Clinical Perspective
DD Wang, E Toledo, A Hruby, BA Rosner, WC Willett, Q Sun, C Razquin, Y Zheng, M Ruiz-Canela, M Guasch-Ferré, D Corella, E Gómez-Gracia, M Fiol, R Estruch, E Ros, J Lapetra, M Fito, F Aros, L Serra-Majem, CH Lee, CB Clish, L Liang, J Salas-Salvadó, MA Martínez-González, FB Hu
Circulation 2017
Metabolomic profiles as reliable biomarkers of dietary composition
T Esko, JN Hirschhorn, HA Feldman, YH Hsu, AA Deik, CB Clish, CB Ebbeling, DS Ludwig
The American journal of clinical nutrition 2017
A Decade of Genetic and Metabolomic Contributions to Type 2 Diabetes Risk Prediction
J Merino, MS Udler, A Leong, JB Meigs
Current Diabetes Reports 2017
Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial
E Baye, J Ukropec, MP de Courten, S Vallova, P Krumpolec, T Kurdiova, G Aldini, B Ukropcova, B Courten
Scientific Reports 2017
Impaired β -Oxidation and Altered Complex Lipid Fatty Acid Partitioning with Advancing CKD
F Afshinnia, TM Rajendiran, T Soni, J Byun, S Wernisch, KM Sas, J Hawkins, K Bellovich, D Gipson, G Michailidis, S Pennathur
Journal of the American Society of Nephrology : JASN 2017
Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model
KM Sas, J Lin, TM Rajendiran, T Soni, V Nair, LM Hinder, HV Jagadish, TW Gardner, SF Abcouwer, FC Brosius, EL Feldman, M Kretzler, G Michailidis, S Pennathur
Journal of lipid research 2017
Metabolites Associated With Risk of Developing Mobility Disability in the Health, Aging and Body Composition Study
RA Murphy, S Moore, M Playdon, S Kritchevsky, AB Newman, S Satterfield, H Ayonayon, C Clish, R Gerszten, TB Harris
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2017
Lipidomic risk score independently and cost-effectively predicts risk of future type 2 diabetes: results from diverse cohorts
M Mamtani, H Kulkarni, G Wong, JM Weir, CK Barlow, TD Dyer, L Almasy, MC Mahaney, AG Comuzzie, DC Glahn, DJ Magliano, P Zimmet, J Shaw, S Williams-Blangero, R Duggirala, J Blangero, PJ Meikle, JE Curran
Lipids in Health and Disease 2016
Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome
S Sales, J Graessler, S Ciucci, R Al-Atrib, T Vihervaara, K Schuhmann, D Kauhanen, M Sysi-Aho, SR Bornstein, M Bickle, CV Cannistraci, K Ekroos, A Shevchenko
Scientific Reports 2016
Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes
P Willeit, P Skroblin, AR Moschen, X Yin, D Kaudewitz, A Zampetaki, T Barwari, M Whitehead, CM Ramírez, L Goedeke, N Rotllan, E Bonora, AD Hughes, P Santer, C Fernández-Hernando, H Tilg, J Willeit, S Kiechl, M Mayr
Diabetes 2016
The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice
S Casteras, A Abdul-Wahed, M Soty, F Vulin, H Guillou, M Campana, HL Stunff, L Pirola, F Rajas, G Mithieux, A Gautier-Stein
Diabetologia 2016
Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program
GA Walford, Y Ma, C Clish, JC Florez, TJ Wang, RE Gerszten
Diabetes 2016
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
LA Lotta, RA Scott, SJ Sharp, S Burgess, J Luan, T Tillin, AF Schmidt, F Imamura, ID Stewart, JR Perry, L Marney, A Koulman, ED Karoly, NG Forouhi, RJ Sjögren, E Näslund, JR Zierath, A Krook, DB Savage, JL Griffin, N Chaturvedi, AD Hingorani, KT Khaw, I Barroso, MI McCarthy, S ORahilly, NJ Wareham, C Langenberg, C Minelli
PLoS Medicine 2016
Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans: Lipidomics in Insulin Resistance and Obesity
KT Tonks, AC Coster, MJ Christopher, R Chaudhuri, A Xu, J Gagnon-Bartsch, DJ Chisholm, DE James, PJ Meikle, JR Greenfield, D Samocha-Bonet
Obesity 2016
Lipidomics—Reshaping the Analysis and Perception of Type 2 Diabetes
D Markgraf, H Al-Hasani, S Lehr
International journal of molecular sciences 2016
What Have Metabolomics Approaches Taught Us About Type 2 Diabetes?
A Gonzalez-Franquesa, AM Burkart, E Isganaitis, ME Patti
Current Diabetes Reports 2016
Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes
JE Ho, MG Larson, A Ghorbani, S Cheng, MH Chen, M Keyes, EP Rhee, CB Clish, RS Vasan, RE Gerszten, TJ Wang, D Meyre
PloS one 2016
An exome array study of the plasma metabolome
EP Rhee, Q Yang, B Yu, X Liu, S Cheng, A Deik, KA Pierce, K Bullock, JE Ho, D Levy, JC Florez, S Kathiresan, MG Larson, RS Vasan, CB Clish, TJ Wang, E Boerwinkle, CJ ODonnell, RE Gerszten
Nature Communications 2016
Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study)
D Ko, EM Riles, EG Marcos, JW Magnani, SA Lubitz, H Lin, MT Long, RB Schnabel, DD McManus, PT Ellinor, VS Ramachandran, TJ Wang, RE Gerszten, EJ Benjamin, X Yin, M Rienstra
The American Journal of Cardiology 2016
Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis
M Guasch-Ferré, A Hruby, E Toledo, CB Clish, MA Martínez-González, J Salas-Salvadó, FB Hu
Diabetes care 2016
Human gut microbes impact host serum metabolome and insulin sensitivity
HK Pedersen, V Gudmundsdottir, HB Nielsen, T Hyotylainen, T Nielsen, BA Jensen, K Forslund, F Hildebrand, E Prifti, G Falony, EL Chatelier, F Levenez, J Doré, I Mattila, DR Plichta, P Pöhö, LI Hellgren, M Arumugam, S Sunagawa, S Vieira-Silva, T Jørgensen, JB Holm, K Trošt, MH Consortium, K Kristiansen, S Brix, J Raes, J Wang, T Hansen, P Bork, S Brunak, M Oresic, SD Ehrlich, O Pedersen
Nature 2016
Metabolite Profiles Predict Acute Kidney Injury and Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement
S Elmariah, LA Farrell, M Daher, X Shi, MJ Keyes, CH Cain, E Pomerantsev, GJ Vlahakes, I Inglessis, JJ Passeri, IF Palacios, CS Fox, EP Rhee, RE Gerszten
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2016
Intervention Trials with the Mediterranean Diet in Cardiovascular Prevention: Understanding Potential Mechanisms through Metabolomic Profiling
MA Martinez-Gonzalez, M Ruiz-Canela, A Hruby, L Liang, A Trichopoulou, FB Hu
The Journal of nutrition 2016
Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis
T Suvitaival, O Mantere, T Kieseppä, I Mattila, P Pöhö, T Hyötyläinen, J Suvisaari, M Orešič
Translational Psychiatry 2016
Detection of Independent Associations of Plasma Lipidomic Parameters with Insulin Sensitivity Indices Using Data Mining Methodology
S Kopprasch, S Dheban, K Schuhmann, A Xu, KM Schulte, CJ Simeonovic, PE Schwarz, SR Bornstein, A Shevchenko, J Graessler, V Sánchez-Margalet
PloS one 2016
An Unbiased Lipidomics Approach Identifies Early Second Trimester Lipids Predictive of Maternal Glycemic Traits and Gestational Diabetes Mellitus
L Lu, A Koulman, CJ Petry, B Jenkins, L Matthews, IA Hughes, CL Acerini, KK Ong, DB Dunger
Diabetes care 2016
Lipidomic Signature of Progression of Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort
F Afshinnia, TM Rajendiran, A Karnovsky, T Soni, X Wang, D Xie, W Yang, T Shafi, MR Weir, J He, CS Brecklin, EP Rhee, JR Schelling, A Ojo, H Feldman, G Michailidis, S Pennathur, LJ Appel, AS Go, JW Kusek, JP Lash, RR Townsend
Kidney International Reports 2016
Identification of Shared and Unique Serum Lipid Profiles in Diabetes Mellitus and Myocardial Infarction
S Kjellqvist, C Klose, MA Surma, G Hindy, IG Mollet, A Johansson, P Chavaux, J Gottfries, K Simons, O Melander, C Fernandez
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2016
Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association
JF Ferguson, H Allayee, RE Gerszten, F Ideraabdullah, PM Kris-Etherton, JM Ordovás, EB Rimm, TJ Wang, BJ Bennett
Circulation. Cardiovascular genetics 2016
Metabolomics: an emerging but powerful tool for precision medicine
CB Clish
Molecular Case Studies 2015
The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
C Saponaro, M Gaggini, F Carli, A Gastaldelli
Nutrients 2015
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
J Miao, AV Ling, PV Manthena, ME Gearing, MJ Graham, RM Crooke, KJ Croce, RM Esquejo, CB Clish, E Torrecilla, GF Vázquez, MA Rubio, L Cabrerizo, A Barabash, AS Pernaute, AJ Torres, D Vicent, SB Biddinger
Nature Communications 2015
Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes
M Eiden, A Koulman, M Hatunic, JA West, S Murfitt, M Osei, C Adams, X Wang, Y Chu, L Marney, LD Roberts, S O’Rahilly, RK Semple, DB Savage, JL Griffin
Genome Medicine 2015
Phenotypic flexibility as a measure of health: the optimal nutritional stress response test
JH Stroeve, H Wietmarschen, BH Kremer, B Ommen, S Wopereis
Genes & Nutrition 2015
HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation
JB Carroll, A Deik, E Fossale, RM Weston, JR Guide, J Arjomand, S Kwak, CB Clish, ME MacDonald, S Humbert
PloS one 2015
Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension:
EP Rhee, CB Clish, KA Pierce, A Saad, LO Lerman, SC Textor
Journal of Hypertension 2015
Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics
E Pretorius, J Bester, N Vermeulen, S Alummoottil, P Soma, AV Buys, DB Kell
Cardiovascular Diabetology 2015
Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes
N Yokoi, M Beppu, E Yoshida, R Hoshikawa, S Hidaka, T Matsubara, M Shinohara, Y Irino, N Hatano, S Seino
Metabolomics 2015
Metabolomics and Diabetes: Analytical and Computational Approaches
KM Sas, A Karnovsky, G Michailidis, S Pennathur
Diabetes 2015
Metabolite Profiling and Cardiovascular Event Risk: A Prospective Study of 3 Population-Based Cohorts
P Wurtz, AS Havulinna, P Soininen, T Tynkkynen, D Prieto-Merino, T Tillin, A Ghorbani, A Artati, Q Wang, M Tiainen, AJ Kangas, J Kettunen, J Kaikkonen, V Mikkila, A Jula, M Kahonen, T Lehtimaki, DA Lawlor, TR Gaunt, AD Hughes, N Sattar, T Illig, J Adamski, TJ Wang, M Perola, S Ripatti, RS Vasan, OT Raitakari, RE Gerszten, JP Casas, N Chaturvedi, M Ala-Korpela, V Salomaa
Circulation 2015
Distinct metabolomic signatures are associated with longevity in humans
S Cheng, MG Larson, EL McCabe, JM Murabito, EP Rhee, JE Ho, PF Jacques, A Ghorbani, M Magnusson, AL Souza, AA Deik, KA Pierce, K Bullock, CJ O’Donnell, O Melander, CB Clish, RS Vasan, RE Gerszten, TJ Wang
Nature Communications 2015
The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics
M Lappas, PA Mundra, G Wong, K Huynh, D Jinks, HM Georgiou, M Permezel, PJ Meikle
Diabetologia 2015
Association between insulin resistance and plasma amino acid profile in non-diabetic Japanese subjects
C Yamada, M Kondo, N Kishimoto, T Shibata, Y Nagai, T Imanishi, T Oroguchi, N Ishii, Y Nishizaki
Journal of Diabetes Investigation 2015
CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome
MA Lankinen, K Hanhineva, M Kolehmainen, M Lehtonen, S Auriola, H Mykkänen, K Poutanen, U Schwab, M Uusitupa, AG Passi
PloS one 2015
Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission
T Arora, V Velagapudi, DJ Pournaras, R Welbourn, CW le Roux, M Orešič, F Bäckhed, M Covasa
PloS one 2015
Defining the Metabolome: Size, Flux, and Regulation
N Zamboni, A Saghatelian, GJ Patti
Molecular Cell 2015
Edible Bird’s Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats
Z Yida, MU Imam, M Ismail, DJ Ooi, N Sarega, NH Azmi, N Ismail, KW Chan, Z Hou, NB Yusuf
Journal of Diabetes Research 2015
Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study
C Morris, CM O’Grada, MF Ryan, MJ Gibney, HM Roche, ER Gibney, L Brennan
Lipids in Health and Disease 2015
A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes
S Park, KC Sadanala, EK Kim
Molecules and Cells 2015
Metabolomics Reveals Metabolically Healthy and Unhealthy Obese Individuals Differ in their Response to a Caloric Challenge
F Badoud, KP Lam, M Perreault, MA Zulyniak, P Britz-McKibbin, DM Mutch, HM Roche
PloS one 2015
Hyphenating size-exclusion chromatography with electrospray mass spectrometry; using on-line liquid-liquid extraction to study the lipid composition of lipoprotein particles: Lipoprotein analysis
M Osei, JL Griffin, A Koulman
Rapid communications in mass spectrometry : RCM 2015
Lipidomics to Assess Omega 3 Bioactivity
F Visioli
Journal of Clinical Medicine 2015
Platelet Lipidomics: Modern Day Perspective on Lipid Discovery and Characterization in Platelets
VB ODonnell, RC Murphy, SP Watson
Circulation research 2014
Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques
J Yaligar, V Gopalan, OW Kiat, S Sugii, G Shui, BD Lam, CJ Henry, MR Wenk, ES Tai, SS Velan
PloS one 2014
Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy
S Kume, D Koya, T Uzu, H Maegawa
BioMed Research International 2014
Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects
MM Yore, I Syed, PM Moraes-Vieira, T Zhang, MA Herman, EA Homan, RT Patel, J Lee, S Chen, OD Peroni, AS Dhaneshwar, A Hammarstedt, U Smith, TE McGraw, A Saghatelian, BB Kahn
Cell 2014
The development and validation of a fast and robust dried blood spot based lipid profiling method to study infant metabolism
A Koulman, P Prentice, MC Wong, L Matthews, NJ Bond, M Eiden, JL Griffin, DB Dunger
Metabolomics 2014
Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up
DO Mook-Kanamori, W Römisch-Margl, G Kastenmüller, C Prehn, AK Petersen, T Illig, C Gieger, R Wang-Sattler, C Meisinger, A Peters, J Adamski, K Suhre
Journal of Endocrinological Investigation 2014
Introduction to personalized medicine in diabetes mellitus
HS Glauber, N Rishe, E Karnieli
Rambam Maimonides Medical Journal 2014
Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry
T Cajka, O Fiehn
TrAC Trends in Analytical Chemistry 2014
Metabolite Traits and Genetic Risk Provide Complementary Information for the Prediction of Future Type 2 Diabetes
GA Walford, BC Porneala, M Dauriz, JL Vassy, S Cheng, EP Rhee, TJ Wang, JB Meigs, RE Gerszten, JC Florez
Diabetes care 2014
Placing epidemiological results in the context of multiplicity and typical correlations of exposures
CJ Patel, JP Ioannidis
Journal of epidemiology and community health 2014
Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity
L Zhu, MN Martinez, CH Emfinger, BT Palmisano, JM Stafford
American journal of physiology. Endocrinology and metabolism 2014
A systematic survey of lipids across mouse tissues
M Jain, S Ngoy, SA Sheth, RA Swanson, EP Rhee, R Liao, CB Clish, VK Mootha, R Nilsson
American journal of physiology. Endocrinology and metabolism 2014
Applying metabolomics to uncover novel biology in ARDS
AJ Rogers, MA Matthay
American journal of physiology. Lung cellular and molecular physiology 2014
Mass Spectrometry-based Lipidomics and Its Application toBiomedical Research
Z Wu, JC Shon, KH Liu
Journal of Lifestyle Medicine 2014
Metabolomic Derangements Are Associated with Mortality in Critically Ill Adult Patients
AJ Rogers, M McGeachie, RM Baron, L Gazourian, JA Haspel, K Nakahira, LE Fredenburgh, GM Hunninghake, BA Raby, MA Matthay, RM Otero, VG Fowler, EP Rivers, CW Woods, S Kingsmore, RJ Langley, AM Choi, SM Parikh
PloS one 2014
Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity
Montoliu I, Scherer M, Beguelin F, DaSilva L, Mari D, Salvioli S, Martin FP, Capri M, Bucci L, Ostan R, Garagnani P, Monti D, Biagi E, Brigidi P, Kussmann M, Rezzi S, Franceschi C, Collino S
Aging 2014
2-aminoadipic acid is a novel biomarker of diabetes risk and modulates glucose homeostasis
Thomas Wang, Debby Ngo, Nikolaos Psychogios, Andre Dejam, Martin Larson, Ramachandran Vasan, Anahita Ghorbani, John O'Sullivan, Susan Cheng, Eugene Rhee, Sumita Sinha, Elizabeth McCabe, Caroline Fox, Christopher O'Donnell, Jennifer Ho, Jose Florez, Martin Magnusson, Kerry Pierce, Amanda Souza, Yi Yu, Christian Carter, Peter Light, Olle Melander, Clary Clish, Robert E. Gerszten
Journal of Clinical Investigation 2013
Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
M Orešič, T Hyötyläinen, A Kotronen, P Gopalacharyulu, H Nygren, J Arola, S Castillo, I Mattila, A Hakkarainen, RJ Borra, MJ Honka, A Verrijken, S Francque, P Iozzo, M Leivonen, N Jaser, A Juuti, TI Sørensen, P Nuutila, L Gaal, H Yki-Järvinen
Diabetologia 2013
Plasma sphingosine-1-phosphate is elevated in obesity
GM Kowalski, AL Carey, A Selathurai, BA Kingwell, CR Bruce
PloS one 2013
Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice
ER Miraldi, H Sharfi, RH Friedline, H Johnson, T Zhang, KS Lau, HJ Ko, TG Curran, KM Haigis, MB Yaffe, R Bonneau, DA Lauffenburger, BB Kahn, JK Kim, BG Neel, A Saghatelian, FM White
Integrative Biology 2013
Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila
LP Musselman, JL Fink, PV Ramachandran, BW Patterson, AL Okunade, E Maier, MR Brent, J Turk, TJ Baranski
The Journal of biological chemistry 2013
Relationship between postprandial metabolomics and colon motility in children with constipation
L Rodriguez, LD Roberts, J LaRosa, N Heinz, R Gerszten, S Nurko, AM Goldstein
Neurogastroenterology & Motility 2013
Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach
C Menni, E Fauman, I Erte, JR Perry, G Kastenmuller, SY Shin, AK Petersen, C Hyde, M Psatha, KJ Ward, W Yuan, M Milburn, CN Palmer, TM Frayling, J Trimmer, JT Bell, C Gieger, RP Mohney, MJ Brosnan, K Suhre, N Soranzo, TD Spector
Diabetes 2013
A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort
EP Rhee, JE Ho, MH Chen, D Shen, S Cheng, MG Larson, A Ghorbani, X Shi, IT Helenius, CJ O’Donnell, AL Souza, A Deik, KA Pierce, K Bullock, GA Walford, RS Vasan, JC Florez, C Clish, JR Yeh, TJ Wang, RE Gerszten
Cell Metabolism 2013
Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity
T Geng, W Hu, MH Broadwater, JM Snider, J Bielawski, SB Russo, JH Schwacke, J Ross, LA Cowart
Diabetologia 2013
Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research
MC Cornelis, FB Hu
Current Nutrition Reports 2013
Biomolecular Signatures of Diabetic Wound Healing by Structural Mass Spectrometry
KM Hines, S Ashfaq, JM Davidson, SR Opalenik, JP Wikswo, JA McLean
Analytical Chemistry 2013
Topographical body fat distribution links to amino acid and lipid metabolism in healthy non-obese women
FP Martin, I Montoliu, S Collino, M Scherer, P Guy, I Tavazzi, A Thorimbert, S Moco, MP Rothney, DL Ergun, M Beaumont, F Ginty, SD Qanadli, L Favre, V Giusti, S Rezzi
PloS one 2013
The potential of novel biomarkers to improve risk prediction of type 2 diabetes
C Herder, B Kowall, AG Tabak, W Rathmann
Diabetologia 2013
Inclusion of plasma lipid species improves classification of individuals at risk of type 2 diabetes
G Wong, CK Barlow, JM Weir, JB Jowett, DJ Magliano, P Zimmet, J Shaw, PJ Meikle
PloS one 2013
Plasma lipid composition and risk of developing cardiovascular disease
C Fernandez, M Sandin, JL Sampaio, P Almgren, K Narkiewicz, M Hoffmann, T Hedner, B Wahlstrand, K Simons, A Shevchenko, P James, O Melander
PloS one 2013
Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans
EC Pino, CM Webster, CE Carr, AA Soukas
Journal of visualized experiments : JoVE 2013
Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties
SB Russo, R Tidhar, AH Futerman, LA Cowart
The Journal of biological chemistry 2013
Clinical metabolomics paves the way towards future healthcare strategies
S Collino, FP Martin, S Rezzi
British Journal of Clinical Pharmacology 2013
A combined epidemiologic and metabolomic approach improves CKD prediction
EP Rhee, CB Clish, A Ghorbani, MG Larson, S Elmariah, E McCabe, Q Yang, S Cheng, K Pierce, A Deik, AL Souza, L Farrell, C Domos, RW Yeh, I Palacios, K Rosenfield, RS Vasan, JC Florez, TJ Wang, CS Fox, RE Gerszten
Journal of the American Society of Nephrology : JASN 2013
Metabolite profiles during oral glucose challenge
JE Ho, MG Larson, RS Vasan, A Ghorbani, S Cheng, EP Rhee, JC Florez, CB Clish, RE Gerszten, TJ Wang
Diabetes 2013
Lipidomics of familial longevity
V Gonzalez-Covarrubias, M Beekman, HW Uh, A Dane, J Troost, I Paliukhovich, FM Kloet, J Houwing-Duistermaat, RJ Vreeken, T Hankemeier, EP Slagboom
Aging Cell 2013
Metabolomics Reveals Broad-Scale Metabolic Perturbations in Hyperglycemic Mothers During Pregnancy
DM Scholtens, MJ Muehlbauer, NR Daya, RD Stevens, AR Dyer, LP Lowe, BE Metzger, CB Newgard, JR Bain, WL Lowe
Diabetes care 2013
"Prediction Is Very Hard, Especially About the Future": New Biomarkers for Type 2 Diabetes?
WL Lowe, JR Bain
Diabetes 2013
Serum TAG Analysis Differentiates Between Genetic and Obesity-Associated NAFLD
DG Mashek, AS Greenberg
Diabetes 2013
Reproducibility of Metabolomic Profiles among Men and Women in 2 Large Cohort Studies
MK Townsend, CB Clish, P Kraft, C Wu, AL Souza, AA Deik, SS Tworoger, BM Wolpin
Clinical chemistry 2013
Plasma lipid profiling in a large population-based cohort
JM Weir, G Wong, CK Barlow, MA Greeve, A Kowalczyk, L Almasy, AG Comuzzie, MC Mahaney, JB Jowett, J Shaw, JE Curran, J Blangero, PJ Meikle
Journal of lipid research 2013
A Plasma Long‐Chain Acylcarnitine Predicts Cardiovascular Mortality in Incident Dialysis Patients
S Kalim, CB Clish, J Wenger, S Elmariah, RW Yeh, JJ Deferio, K Pierce, A Deik, RE Gerszten, R Thadhani, EP Rhee
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2013
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
Nature 2013
The Role of Sphingolipids and (Dihydro)Ceramide Synthase 5 in Diabetic Cardiomyopathy
Sarah Russo, Catalin Baicu, An Van Laer, Tuoyu Geng, Harinath Kasiganesan, Michael R. Zile, L. Ashley Cowart
Journal of Clinical Investigation 2012
Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice
VG Demarco, DA Ford, EJ Henriksen, AR Aroor, MS Johnson, J Habibi, L Ma, M Yang, CJ Albert, JW Lally, CA Ford, M Prasannarong, MR Hayden, AT Whaley-Connell, JR Sowers
Endocrinology 2012
Novel biomarkers for pre-diabetes identified by metabolomics
R Wang-Sattler, Z Yu, C Herder, AC Messias, A Floegel, Y He, K Heim, M Campillos, C Holzapfel, B Thorand, H Grallert, T Xu, E Bader, C Huth, K Mittelstrass, A Döring, C Meisinger, C Gieger, C Prehn, W Roemisch-Margl, M Carstensen, L Xie, H Yamanaka-Okumura, G Xing, U Ceglarek, J Thiery, G Giani, H Lickert, X Lin, Y Li, H Boeing, HG Joost, MH de Angelis, W Rathmann, K Suhre, H Prokisch, A Peters, T Meitinger, M Roden, HE Wichmann, T Pischon, J Adamski, T Illig
Molecular Systems Biology 2012
Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes
MN Barber, S Risis, C Yang, PJ Meikle, M Staples, MA Febbraio, CR Bruce
PloS one 2012
Shotgun Lipidomics by Sequential Precursor Ion Fragmentation on a Hybrid Quadrupole Time-of-Flight Mass Spectrometer
B Simons, D Kauhanen, T Sylvänne, K Tarasov, E Duchoslav, K Ekroos
Metabolites 2012
Obesity and psychotic disorders: uncovering common mechanisms through metabolomics
M Oresic
Disease models & mechanisms 2012
Fish Oil Supplementation Alters the Plasma Lipidomic Profile and Increases Long-Chain PUFAs of Phospholipids and Triglycerides in Healthy Subjects
I Ottestad, S Hassani, GI Borge, A Kohler, G Vogt, T Hyötyläinen, M Orešič, KW Brønner, KB Holven, SM Ulven, MC Myhrstad
PloS one 2012
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations
V Leoni, L Strittmatter, G Zorzi, F Zibordi, S Dusi, B Garavaglia, P Venco, C Caccia, AL Souza, A Deik, CB Clish, M Rimoldi, E Ciusani, E Bertini, N Nardocci, VK Mootha, V Tiranti
Molecular Genetics and Metabolism 2012
A short-term diet and exercise intervention ameliorates inflammation and markers of metabolic health in overweight/obese children
A Izadpanah, RJ Barnard, AJ Almeda, GC Baldwin, SA Bridges, ER Shellman, CF Burant, CK Roberts
American journal of physiology. Endocrinology and metabolism 2012
Metabolomics in the studies of islet autoimmunity and type 1 diabetes
M Oresic
The review of diabetic studies : RDS 2012
Mapping the regioisomeric distribution of fatty acids in triacylglycerols by hybrid mass spectrometry
K Nagy, L Sandoz, F Destaillats, O Schafer
Journal of lipid research 2012
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach
A Floegel, N Stefan, Z Yu, K Mühlenbruch, D Drogan, HG Joost, A Fritsche, HU Häring, MH de Angelis, A Peters, M Roden, C Prehn, R Wang-Sattler, T Illig, MB Schulze, J Adamski, H Boeing, T Pischon
Diabetes 2012
Metabolomic prediction of diabetes and cardiovascular risk
S Dagogo-Jack
Medical Principles and Practice 2012
Circulating metabolite predictors of glycemia in middle-aged men and women
P Würtz, M Tiainen, VP Mäkinen, AJ Kangas, P Soininen, J Saltevo, S Keinänen-Kiukaanniemi, P Mäntyselkä, T Lehtimäki, M Laakso, A Jula, M Kähönen, M Vanhala, M Ala-Korpela
Diabetes care 2012
Metabolic signatures of insulin resistance in 7,098 young adults
P Würtz, VP Mäkinen, P Soininen, AJ Kangas, T Tukiainen, J Kettunen, MJ Savolainen, T Tammelin, JS Viikari, T Rönnemaa, M Kähönen, T Lehtimäki, S Ripatti, OT Raitakari, MR Järvelin, M Ala-Korpela
Diabetes 2012
Perspectives on Systems Biology Applications in Diabetic Kidney Disease
CV Komorowsky, FC 3rd, S Pennathur, M Kretzler
Journal of Cardiovascular Translational Research 2012
Metabolic Signature of Chronic Kidney Disease: the search continues
AV Mathew, S Pennathur
American journal of kidney diseases : the official journal of the National Kidney Foundation 2012
Inflammatory-Induced Hibernation in the Fetus: Priming of Fetal Sheep Metabolism Correlates with Developmental Brain Injury
M Keller, DP Enot, MP Hodson, EI Igwe, HP Deigner, J Dean, H Bolouri, H Hagberg, C Mallard
PloS one 2011
Serum Lipidomics Profiling using LC-MS and High Energy Collisional Dissociation Fragmentation: Focus on Triglyceride Detection and Characterization
SS Bird, VR Marur, MJ Sniatynski, HK Greenberg, BS Kristal
Analytical Chemistry 2011

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