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Citations to this article

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Patrick Seale, … , Saverio Cinti, Bruce M. Spiegelman
Patrick Seale, … , Saverio Cinti, Bruce M. Spiegelman
Published December 1, 2010
Citation Information: J Clin Invest. 2011;121(1):96-105. https://doi.org/10.1172/JCI44271.
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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

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Abstract

The white adipose organ is composed of both subcutaneous and several intra-abdominal depots. Excess abdominal adiposity is a major risk factor for metabolic disease in rodents and humans, while expansion of subcutaneous fat does not carry the same risks. Brown adipose produces heat as a defense against hypothermia and obesity, and the appearance of brown-like adipocytes within white adipose tissue depots is associated with improved metabolic phenotypes. Thus, understanding the differences in cell biology and function of these different adipose cell types and depots may be critical to the development of new therapies for metabolic disease. Here, we found that Prdm16, a brown adipose determination factor, is selectively expressed in subcutaneous white adipocytes relative to other white fat depots in mice. Transgenic expression of Prdm16 in fat tissue robustly induced the development of brown-like adipocytes in subcutaneous, but not epididymal, adipose depots. Prdm16 transgenic mice displayed increased energy expenditure, limited weight gain, and improved glucose tolerance in response to a high-fat diet. shRNA-mediated depletion of Prdm16 in isolated subcutaneous adipocytes caused a sharp decrease in the expression of thermogenic genes and a reduction in uncoupled cellular respiration. Finally, Prdm16 haploinsufficiency reduced the brown fat phenotype in white adipose tissue stimulated by β-adrenergic agonists. These results demonstrate that Prdm16 is a cell-autonomous determinant of a brown fat–like gene program and thermogenesis in subcutaneous adipose tissues.

Authors

Patrick Seale, Heather M. Conroe, Jennifer Estall, Shingo Kajimura, Andrea Frontini, Jeff Ishibashi, Paul Cohen, Saverio Cinti, Bruce M. Spiegelman

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
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iScience 2022
TFAM expression in brown adipocytes confers obesity resistance by secreting extracellular vesicles that promote self-activation
Fujii M, Setoyama D, Gotoh K, Dozono Y, Yagi M, Ikeda M, Ide T, Uchiumi T, Kang D
iScience 2022
Remodeling of Adipose Tissues by Fatty Acids: Mechanistic Update on Browning and Thermogenesis by n-3 Polyunsaturated Fatty Acids.
Raj RR, Lofquist S, Lee MJ
Pharmaceutical Research 2022
Novel Plant Extract Ameliorates Metabolic Disorder through Activation of Brown Adipose Tissue in High-Fat Diet-Induced Obese Mice
Kim JW, Yang YM, Kwon EY, Choi JY
International journal of molecular sciences 2022
The role of somatosensory innervation of adipose tissues.
Wang Y, Leung VH, Zhang Y, Nudell VS, Loud M, Servin-Vences MR, Yang D, Wang K, Moya-Garzon MD, Li VL, Long JZ, Patapoutian A, Ye L
Nature 2022
Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases
Machado SA, Pasquarelli-do-Nascimento G, da Silva DS, Farias GR, de Oliveira Santos I, Baptista LB, Magalhães KG
Nutrition & Metabolism 2022
Relationships between the expression of adipose genes and profiles of hospitalized dogs.
Sugiyama Y, Shimokawa F, Sugiyama K, Kobayashi T, Yamashita Y, Kazama K, Onda K, Funaba M, Murakami M
Veterinary Research Communications 2022
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease.
Uddin MDM, Nguyen NQH, Yu B, Brody JA, Pampana A, Nakao T, Fornage M, Bressler J, Sotoodehnia N, Weinstock JS, Honigberg MC, Nachun D, Bhattacharya R, Griffin GK, Chander V, Gibbs RA, Rotter JI, Liu C, Baccarelli AA, Chasman DI, Whitsel EA, Kiel DP, Murabito JM, Boerwinkle E, Ebert BL, Jaiswal S, Floyd JS, Bick AG, Ballantyne CM, Psaty BM, Natarajan P, Conneely KN
Nature Communications 2022
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases.
Yin X, Chen Y, Ruze R, Xu R, Song J, Wang C, Xu Q
Signal Transduction and Targeted Therapy 2022
The Adipose Organ Is a Unitary Structure in Mice and Humans
Giordano A, Cinti F, Canese R, Carpinelli G, Colleluori G, Di Vincenzo A, Palombelli G, Severi I, Moretti M, Redaelli C, Partridge J, Zingaretti MC, Agostini A, Sternardi F, Giovagnoni A, Castorina S, Cinti S
Biomedicines 2022
Olanzapine induces weight gain in offspring of prenatally exposed poly I:C rats by reducing brown fat thermogenic activity
Chen X, Liu L, Zeng Y, Li D, Liu X, Hu C
Frontiers in pharmacology 2022
Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced Obesity
Becerril S, Tuero C, Cienfuegos JA, Rodríguez A, Catalán V, Ramírez B, Valentí V, Moncada R, Unamuno X, Gómez-Ambrosi J, Frühbeck G
International journal of molecular sciences 2022
Selection-driven adaptation to the extreme Antarctic environment in the Emperor penguin.
Pirri F, Ometto L, Fuselli S, Fernandes FAN, Ancona L, Perta N, Di Marino D, Le Bohec C, Zane L, Trucchi E
Heredity 2022
Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity
Mathur N, Severinsen MC, Jensen ME, Naver L, Schrölkamp M, Laye MJ, Watt MJ, Nielsen S, Krogh-Madsen R, Pedersen BK, Scheele C
Frontiers in Cell and Developmental Biology 2022
In vitro transdifferentiated signatures of goat preadipocytes into mammary epithelial cells revealed by DNA methylation and transcriptome profiling
Yan XR, Shi T, Xiao JY, Liu YF, Zheng HL
The Journal of biological chemistry 2022
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex
Shen H, He T, Wang S, Hou L, Wei Y, Liu Y, Mo C, Zhao Z, You W, Guo H, Li B
Theranostics 2022
Neonatal intake of Omega-3 fatty acids enhances lipid oxidation in adipocyte precursors
Varshney R, Das S, Trahan GD, Farriester JW, Mullen GP, Kyere-Davies G, Presby DM, Houck JA, Webb PG, Dzieciatkowska M, Jones KL, Rodeheffer MS, Friedman JE, MacLean PS, Rudolph MC
iScience 2022
Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism
Chae SA, Son JS, de Avila JM, Du M, Zhu MJ
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2022
LSD1 for the Targeted Regulation of Adipose Tissue
Chen L, Sun X, Chen D, Gui Q
Current issues in molecular biology 2022
Brown Adipose Tissue—A Translational Perspective
Carpentier AC, Blondin DP, Haman F, Richard D
Endocrine reviews 2022
The sympathetic nervous system in the 21st Century: neuro-immune interactions in metabolic homeostasis and obesity
Martinez-Sanchez N, Sweeney O, Sidarta-Oliveira D, Caron A, Stanley SA, Domingos AI
Neuron 2022
Time Restricted Feeding Mitigates Obesity Through Adipocyte Thermogenesis
Hepler C, Weidemann BJ, Waldeck NJ, Marcheva B, Cedernaes J, Thorne AK, Kobayashi Y, Nozawa R, Newman MV, Gao P, Shao M, Ramsey KM, Gupta RK, Bass J
Science (New York, N.Y.) 2022
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis
Shuai Yan, Manju Kumari, Haopeng Xiao, Christopher Jacobs, Shihab Kochumon, Mark Jedrychowski, Edward Chouchani, Rasheed Ahmad, Evan D. Rosen
Journal of Clinical Investigation 2021
Pioglitazone does not synergize with mirabegron to increase beige fat or further improve glucose metabolism
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E Dupont-Versteegden, Philip A. Kern
JCI Insight 2021
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation
R Wu, Y Chen, Y Liu, L Zhuang, W Chen, B Zeng, X Liao, G Guo, Y Wang, X Wang
EMBO reports 2021
Single-cell chromatin accessibility and lipid profiling reveals SCD1-dependent metabolic shift in adipocytes induced by bariatric surgery
B Harlan, HG Park, R Spektor, B Cummings, JT Brenna, PD Soloway, K Sun
PloS one 2021
Beige fat is dispensable for the metabolic benefits associated with myostatin deletion
F Marchildon, J Chi, S O'Connor, H Bediako, P Cohen
Molecular Metabolism 2021
Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity
Z Wang, X Gao, Q Li, H Zhu, X Zhao, M Garcia-Barrio, J Zhang, Y Guo, YE Chen, R Zeng, JR Wu, L Chang
Frontiers in physiology 2021
PRDM16 Inhibits Cell Proliferation and Migration via Epithelial-to-Mesenchymal Transition by Directly Targeting Pyruvate Carboxylase in Papillary Thyroid Cancer
WL Liu, Q Guan, D Wen, B Ma, WB Xu, JQ Hu, WJ Wei, DS Li, Y Wang, J Xiang, T Liao, QH Ji
Frontiers in Cell and Developmental Biology 2021
G q α/G 11 α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity
EA Wilson, H Sun, Z Cui, MT Jahnke, M Pandey, P Metzger, O Gavrilova, M Chen, LS Weinstein
American journal of physiology. Endocrinology and metabolism 2021
Contributions of microRNAs to Peripheral Insulin Sensitivity
K Kim, S Hartig
Endocrinology 2021
Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
BB Brandão, A Poojari, A Rabiee
International journal of molecular sciences 2021
The cellular and functional complexity of thermogenic fat
P Cohen, S Kajimura
Nature Reviews Molecular Cell Biology 2021
D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism
HJ Jeon, DK Choi, JH Choi, S Lee, H Lee, JH Yu, SH Min
Cells 2021
Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes
JD Painter, O Akbari
Frontiers in immunology 2021
Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis
L Crudele, E Piccinin, A Moschetta
Nutrients 2021
Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue
Y Choi, L Yu
Pharmaceutical Research 2021
Overview of the molecular mechanisms contributing to the formation of cancer‑associated adipocytes (Review)
Y Tang, W Zhang, T Sheng, , X Xiong
Molecular medicine reports 2021
Overexpression of Adiponectin Receptor 1 Inhibits Brown and Beige Adipose Tissue Activity in Mice
YJ Chen, CW Lin, YJ Peng, CW Huang, YS Chien, TH Huang, PX Liao, WY Yang, MH Wang, HJ Mersmann, SC Wu, TY Chuang, YY Lin, WH Kuo, ST Ding
International journal of molecular sciences 2021
SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes
F Molinari, A Feraco, S Mirabilii, S Saladini, L Sansone, E Vernucci, G Tomaselli, V Marzolla, D Rotili, MA Russo, MR Ricciardi, A Tafuri, A Mai, M Caprio, M Tafani, A Armani
Cells 2021
The Role of Mondo Family Transcription Factors in Nutrient-Sensing and Obesity
H Ke, Y Luan, S Wu, Y Zhu, X Tong
Frontiers in Endocrinology 2021
Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders
S Pervin, ST Reddy, R Singh
Frontiers in Endocrinology 2021
miR-21 mimic blocks obesity in mice: A novel therapeutic option
S Lhamyani, AM Gentile, RM Giráldez-Pérez, M Feijóo-Cuaresma, SY Romero-Zerbo, M Clemente-Postigo, H Zayed, W Oliva-Olivera, FJ Bermúdez-Silva, J Salas, CL Gómez, A Hmadcha, N Hajji, G Olveira, FJ Tinahones, RE Bekay
Molecular Therapy — Nucleic Acids 2021
LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis
A BastHabersbrunner, C Kiefer, P Weber, T Fromme, A Schießl, PC Schwalie, B Deplancke, Y Li, M Klingenspor
EMBO reports 2021
Browning of White Adipose Tissue as a Therapeutic Tool in the Fight against Atherosclerosis
CL Roth, F Molica, BR Kwak
Metabolites 2021
Recruitment of Thermogenic Fat: Trigger of Fat Burning
Z Wang, X Yu, Y Chen
Frontiers in Endocrinology 2021
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
A Whitehead, FN Krause, A Moran, AD MacCannell, JL Scragg, BD McNally, E Boateng, SA Murfitt, S Virtue, J Wright, J Garnham, GR Davies, J Dodgson, JE Schneider, AJ Murray, C Church, A Vidal-Puig, KK Witte, JL Griffin, LD Roberts
Nature Communications 2021
Circadian Rhythms of the Hypothalamus: From Function to Physiology
RV Drunen, K Eckel-Mahan
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Nutmeg extract potentially alters characteristics of white adipose tissue in rats
R Lesmana, M Siannoto, GI Nugraha, H Goenawan, AK Feinisa, YS Pratiwi, F Veronica, VM Tarawan, S Susianti, U Supratman
Veterinary Medicine and Science 2021
Brown adipose tissue is associated with cardiometabolic health
T Becher, S Palanisamy, DJ Kramer, M Eljalby, SJ Marx, AG Wibmer, SD Butler, CS Jiang, R Vaughan, H Schöder, A Mark, P Cohen
Nature Medicine 2021
Resident and migratory adipose immune cells control systemic metabolism and thermogenesis
K Man, A Kallies, A Vasanthakumar
Cellular and Molecular Immunology 2021
Mouse model of the adipose organ: the heterogeneous anatomical characteristics
KH Chun
Archives of Pharmacal Research 2021
Uncoupling protein-1 expression does not protect mice from diet-induced obesity
H Wang, M Willershäuser, Y Li, T Fromme, K Schnabl, A Bast-Habersbrunner, S Ramisch, S Mocek, M Klingenspor
American journal of physiology. Endocrinology and metabolism 2021
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice
S Wang, Q Cao, X Cui, J Jing, F Li, H Shi, B Xue, H Shi
Biomolecules 2021
Brown Fat Dnmt3b Deficiency Ameliorates Obesity in Female Mice
F Li, X Cui, J Jing, S Wang, H Shi, B Xue, H Shi
Life Sciences 2021
Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease
E Parra-Peralbo, A Talamillo, R Barrio
Frontiers in Cell and Developmental Biology 2021
Epigenetic Regulators of White Adipocyte Browning
R Nanduri
Epigenomes 2021
FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis
H Li, X Zhang, C Huang, H Liu, Q Zhang, Q Sun, Y Jia, S Liu, M Dong, M Hou, Y Liu, H Lin
Molecular Metabolism 2021
Dichotomy in the Impact of Elevated Maternal Glucose Levels on Neonatal Epigenome
I Lim, X Lin, A Teh, Y Wu, L Chen, M He, S Chan, J MacIsaac, J Chan, K Tan, M Chong, M Kobor, K Godfrey, M Meaney, Y Lee, J Eriksson, P Gluckman, Y Chong, N Karnani
The Journal of clinical endocrinology and metabolism 2021
Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure
A Qiao, W Ma, J Deng, J Zhou, C Han, E Zhang, C Boriboun, S Xu, C Zhang, C Jie, J Kim, KM Habegger, H Qiu, TC Zhao, J Zhang, G Qin
The FASEB Journal 2021
CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells
Chakraborty S, Ong WK, Yau WW, Zhou Z, Bhanu Prakash KN, Toh SA, Han W, Yen PM, Sugii S
Stem Cell Research & Therapy 2021
Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat
Chi J, Lin Z, Barr W, Crane A, Zhu XG, Cohen P
eLife 2021
Characterization of structural variation in Tibetans reveals new evidence of high-altitude adaptation and introgression
Quan C, Li Y, Liu X, Wang Y, Ping J, Lu Y, Zhou G
Genome biology 2021
Prdm16-Mediated Browning is Involved in Resistance to Diet-Induced and Monosodium Glutamate-Induced Obesity
Liang J, Jia Y, Yan H, Shen Q, Bian W, Zhao D, Xu Y, Jin Y, Yang M
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2021
ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes
Shao M, Zhang Q, Truong A, Shan B, Vishvanath L, Li L, Seale P, Gupta RK
Genes & development 2021
Is endothelial dysfunction a therapeutic target for Peripheral Artery Disease?
Kumar S, Andueza A, Jo H
Circulation research 2021
Expression of Circulating MicroRNAs and Myokines and Interactions with Serum Osteopontin in Type 2 Diabetic Patients with Moderate and Poor Glycemic Control: A Biochemical and Molecular Study
Al-Rawaf HA, Alghadir AH, Gabr SA
BioMed Research International 2021
Adipose Tissue-Derived Mesenchymal Stem Cells
Bunnell BA
Cells 2021
Flavonoid‐enriched extract from Millettia speciosa Champ prevents obesity by regulating thermogenesis and lipid metabolism in high‐fat diet–induced obese C57BL/6 mice
Wang M, Ma W, Wang Q, Yang Q, Yan X, Tang H, Li Z, Li Y, Feng S, Wang Z
Food Science & Nutrition 2021
Protective Effects of Individual and Combined Low Dose Beta-Carotene and Metformin Treatments against High-Fat Diet-Induced Responses in Mice.
Stojnić B, Serrano A, Sušak L, Palou A, Bonet ML, Ribot J
Nutrients 2021
Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin
Wargent ET, Ahmad SJ, Lu QR, Kostenis E, Arch JR, Stocker CJ
Frontiers in Endocrinology 2021
Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet
Kirschner KM, Foryst-Ludwig A, Gohlke S, Li C, Flores RE, Kintscher U, Schupp M, Schulz TJ, Scholz H
Diabetologia 2021
Cyanidin-3-O-glucoside Regulates the Expression of Ucp1 in Brown Adipose Tissue by Activating Prdm16 Gene.
Han S, Yang Y, Lu Y, Guo J, Han X, Gao Y, Huang W, You Y, Zhan J
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Postnatal exercise protects offspring from high-fat diet-induced reductions in subcutaneous adipocyte beiging in C57Bl6/J mice
Claycombe-Larson KJ, Bundy A, Lance EB, Darland DC, Casperson SL, Roemmich JN
The Journal of Nutritional Biochemistry 2021
Irisin-Associated Neuroprotective and Rehabilitative Strategies for Stroke.
Huberman MA, d'Adesky ND, Niazi QB, Perez-Pinzon MA, Bramlett HM, Raval AP
NeuroMolecular Medicine 2021
Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice.
Teijeiro A, Garrido A, Ferre A, Perna C, Djouder N
Nature metabolism 2021
Long-term intermittent cold exposure affects peri-ovarian adipose tissue and ovarian microenvironment in rats
Zhang L, An G, Wu S, Wang J, Yang D, Zhang Y, Li X
Journal of Ovarian Research 2021
HOXC10 Suppresses Browning to Maintain White Adipocyte Identity
Tan HY, Sim MF, Tan SX, Ng Y, Gan SY, Li H, Neo SP, Gunaratne J, Xu F, Han W
Diabetes 2021
Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system beyond thermogenic adipose tissues
Claflin KE, Flippo KH, Sullivan AI, Naber MC, Zhou B, Neff TJ, Jensen-Cody SO, Potthoff MJ
Molecular Metabolism 2021
The relation of omentin gene expression and glucose homeostasis of visceral and subcutaneous adipose tissues in non-diabetic adults.
Daneshafrooz A, Yuzbashian E, Zarkesh M, Asghari G, Mirmiran P, Hedayati M, Abooshahab R, Fanaei SM, Khalaj A
Molecular Biology Reports 2021
The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, Philip A. Kern
Journal of Clinical Investigation 2020
ASK1 inhibits browning of white adipose tissue in obesity
FC Lucchini, S Wueest, TD Challa, F Item, S Modica, M Borsigova, Y Haim, C Wolfrum, A Rudich, D Konrad
Nature Communications 2020
The Beta3 Adrenergic Receptor in Healthy and Pathological Cardiovascular Tissues
LY Michel, C Farah, JL Balligand
Cells 2020
Insulin/Glucose-Responsive Cells Derived from Induced Pluripotent Stem Cells: Disease Modeling and Treatment of Diabetes
S Gheibi, T Singh, JP da Cunha, M Fex, H Mulder
Cells 2020
Beige Fat Maintenance; Toward a Sustained Metabolic Health
A Rabiee
Frontiers in Endocrinology 2020
Effect of Thyroid Hormones on Adipose Tissue Flexibility
L Volke, K Krause
European Thyroid Journal 2020
Egr1 loss-of-function promotes beige adipocyte differentiation and activation specifically in inguinal subcutaneous white adipose tissue
M Bléher, B Meshko, I Cacciapuoti, R Gergondey, Y Kovacs, D Duprez, A LHonoré, E Havis
Scientific Reports 2020
There and Back Again: Leptin Actions in White Adipose Tissue
N Martínez-Sánchez
International journal of molecular sciences 2020
Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease
X Li, H Wang
Cell & Bioscience 2020
A MicroRNA Linking Human Positive Selection and Metabolic Disorders
L Wang, N Sinnott-Armstrong, A Wagschal, AR Wark, JP Camporez, RJ Perry, F Ji, Y Sohn, J Oh, S Wu, J Chery, BN Moud, A Saadat, SN Dankel, G Mellgren, DS Tallapragada, SM Strobel, MJ Lee, R Tewhey, PC Sabeti, A Schaefer, A Petri, S Kauppinen, RT Chung, A Soukas, J Avruch, SK Fried, H Hauner, RI Sadreyev, GI Shulman, M Claussnitzer, AM Näär
Cell 2020
TSH promotes adiposity by inhibiting the browning of white fat
J Zhang, H Wu, S Ma, L Gao, C Yu, F Jing, J Zhao
Adipocyte 2020
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease
A Chait, LJ den Hartigh
Frontiers in Cardiovascular Medicine 2020
Adipose stem cells in obesity: challenges and opportunities
S Shin, AS El-Sabbagh, BE Lukas, SJ Tanneberger, Y Jiang
Bioscience Reports 2020
Thermogenic adipocytes: lineage, function and therapeutic potential
AE Pollard, D Carling
Biochemical Journal 2020
TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice
P Tougaard, LO Martinsen, DO Lützhøft, HE Jensen, M Flethøj, P Vandenabeele, AE Pedersen, S Skov, AK Hansen, CH Hansen
International Journal of Obesity 2020
The effect of TGFβ1 on thermogenic markers is dependent on the degree of adipocyte differentiation
BR Maharjan, SV McLennan, SM Twigg, PF Williams
Bioscience Reports 2020
The biology of lipid droplet-bound mitochondria
M Veliova, A Petcherski, M Liesa, OS Shirihai
Seminars in Cell & Developmental Biology 2020
Palmitoleic Acid Decreases Non-alcoholic Hepatic Steatosis and Increases Lipogenesis and Fatty Acid Oxidation in Adipose Tissue From Obese Mice
MM Cruz, JJ Simão, RD de Sá, TS Farias, VS da Silva, F Abdala, VJ Antraco, L Armelin-Correa, MI Alonso-Vale
Frontiers in Endocrinology 2020
Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
AJ Knights, EJ Vohralik, PJ Houweling, ES Stout, LJ Norton, SJ Alexopoulos, JJ Yik, HM Jusoh, EM Olzomer, KS Bell-Anderson, KN North, KL Hoehn, M Crossley, KG Quinlan
Nature Communications 2020
Chronic arsenic exposure impairs adaptive thermogenesis in male C57BL/6J mice
F Castriota, PJ Zushin, SS Sanchez, RV Phillips, A Hubbard, A Stahl, MT Smith, JC Wang, MA Merrill
American journal of physiology. Endocrinology and metabolism 2020
Mark4 Inhibited the Browning of White Adipose Tissue by Promoting Adipocytes Autophagy in Mice
K Yang, J Cai, M Pan, Q Sun, C Sun
International journal of molecular sciences 2020
Feeding brown fat: dietary phytochemicals targeting non-shivering thermogenesis to control body weight
C Horvath, C Wolfrum
Proceedings of the Nutrition Society 2020
Do Bariatric Surgeries Enhance Brown/Beige Adipose Tissue Thermogenesis?
MK Hankir, F Seyfried
Frontiers in Endocrinology 2020
Metabolic Improvement via Enhancing Thermogenic Fat-Mediated Non-shivering Thermogenesis: From Rodents to Humans
R Pan, X Zhu, P Maretich, Y Chen
Frontiers in Endocrinology 2020
Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis
C Xing, D Jiang, Y Liu, Q Tang, H Huang
Genes & Diseases 2020
Bisphenol AF promotes inflammation in human white adipocytes
N Chernis, P Masschelin, AR Cox, SM Hartig
American journal of physiology. Cell physiology 2020
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue
B Li, M Zhang, Y Duan, L Shuai, H Jiang, J Li, F Nan, J Li
Acta Pharmacologica Sinica 2020
PRDM16 orchestrates angiogenesis via neural differentiation in the developing brain
L Su, X Lei, H Ma, C Feng, J Jiang, J Jiao
Cell Death and Differentiation 2020
The metabolic effects of mirabegron are mediated primarily by β 3 ‐adrenoceptors
N Dehvari, M Sato, MH Bokhari, A Kalinovich, S Ham, J Gao, HT Nguyen, L Whiting, S Mukaida, J Merlin, LY Chia, D Wootten, RJ Summers, BA Evans, T Bengtsson, DS Hutchinson
Pharmacology Research & Perspectives 2020
Genetic background and diet affect brown adipose gene coexpression networks associated with metabolic phenotypes
C Carson, HA Lawson
Physiological genomics 2020
Studying Brown Adipose Tissue in a Human in vitro Context
I Samuelson, A Vidal-Puig
Frontiers in Endocrinology 2020
Depot-specific UCP1 expression in human white adipose tissue and its association with obesity-related markers
J Lim, HS Park, J Kim, YJ Jang, JH Kim, YJ Lee, Y Heo
International Journal of Obesity 2020
An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models
MJ Choi, SB Jung, SE Lee, SG Kang, JH Lee, MJ Ryu, HK Chung, JY Chang, YK Kim, HJ Hong, H Kim, HJ Kim, CH Lee, A Mardinoglu, HS Yi, M Shong
Diabetologia 2020
Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice
DH Lee, SH Chang, DK Yang, NJ Song, UJ Yun, KW Park
Nutrients 2020
CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling
Y Oguri, K Shinoda, H Kim, DL Alba, WR Bolus, Q Wang, Z Brown, RN Pradhan, K Tajima, T Yoneshiro, K Ikeda, Y Chen, RT Cheang, K Tsujino, CR Kim, VJ Greiner, R Datta, CD Yang, K Atabai, MT McManus, SK Koliwad, BM Spiegelman, S Kajimura
Cell 2020
UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes
K Ikeda, T Yamada
Frontiers in Endocrinology 2020
Browning capabilities of human primary adipose-derived stromal cells compared to SGBS cells
D Halbgebauer, M Dahlhaus, M Wabitsch, P Fischer-Posovszky, D Tews
Scientific Reports 2020
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice
Y Wang, M Gao, F Zhu, X Li, Y Yang, Q Yan, L Jia, L Xie, Z Chen
Nature Communications 2020
Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis
A Fenzl, OC Kulterer, K Spirk, G Mitulović, R Marculescu, M Bilban, S Baumgartner-Parzer, A Kautzky-Willer, L Kenner, J Plutzky, L Quadro, FW Kiefer
Molecular Metabolism 2020
Calsyntenin 3β Is Dynamically Regulated by Temperature in Murine Brown Adipose and Marks Human Multilocular Fat
K Plucińska, NZ Jespersen, EL Brown, PS Petersen, K Rupar, S Nielsen, C Scheele, B Emanuelli
Frontiers in Endocrinology 2020
miR-30a targets gene networks that promote browning of human and mouse adipocytes
PK Saha, MP Hamilton, K Rajapakshe, V Putluri, JB Felix, P Masschelin, AR Cox, M Bajaj, N Putluri, C Coarfa, SM Hartig
American journal of physiology. Endocrinology and metabolism 2020
Combating Obesity With Thermogenic Fat: Current Challenges and Advancements
R Pan, X Zhu, P Maretich, Y Chen
Frontiers in Endocrinology 2020
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
C Ruocco, M Ragni, F Rossi, P Carullo, V Ghini, F Piscitelli, A Cutignano, E Manzo, RM Ioris, F Bontems, L Tedesco, CM Greco, A Pino, I Severi, D Liu, RP Ceddia, L Ponzoni, L Tenori, L Rizzetto, M Scholz, K Tuohy, F Bifari, VD Marzo, C Luchinat, MO Carruba, S Cinti, I Decimo, G Condorelli, R Coppari, S Collins, A Valerio, E Nisoli
Diabetes 2020
The PPAR Ω Pocket: Renewed Opportunities for Drug Development
Å Kaupang, TV Hansen
PPAR Research 2020
Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
AE Pravednikova, SY Shevchenko, VV Kerchev, MR Skhirtladze, SN Larina, ZM Kachaev, AD Egorov, YV Shidlovskii
Molecular Medicine 2020
Multiple roles of HOX proteins in Metastasis: Let me count the ways
J Jonkers, P Pai, S Sukumar
Cancer and Metastasis Reviews 2020
γδT cells and adipocyte IL-17RC control fat innervation and thermogenesis
Hu B, Jin C, Zeng X, Resch JM, Jedrychowski MP, Yang Z, Desai BN, Banks AS, Lowell BB, Mathis D, Spiegelman BM
Nature 2020
Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice.
Wang H, Kuusela S, Rinnankoski-Tuikka R, Dumont V, Bouslama R, Ramadan UA, Waaler J, Linden AM, Chi NW, Krauss S, Pirinen E, Lehtonen S
International Journal of Obesity 2020
Dietary Silk Peptide Prevents High-Fat Diet-Induced Obesity and Promotes Adipose Browning by Activating AMP-Activated Protein Kinase in Mice.
Lee K, Jin H, Chei S, Lee JY, Oh HJ, Lee BY
Nutrients 2020
Exercise-Induced Adaptations to Adipose Tissue Thermogenesis
Vidal P, Stanford KI
Frontiers in Endocrinology 2020
Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue
Patel BV, Yao F, Howenstine A, Takenaka R, Hyatt JA, Sears KE, Shewchuk BM
Journal of Molecular Biology 2020
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Zhang J, Yang J, Yang N, Ma J, Lu D, Dong Y, Liang H, Liu D, Cang M
Lipids in Health and Disease 2020
PVAT: an important guardian of the cardiovascular system.
Liang X, Qi Y, Dai F, Gu J, Yao W
Histology and histopathology 2020
Use of Infrared Thermography to Estimate Brown Fat Activation After a Cooling Protocol in Patients with Severe Obesity That Underwent Bariatric Surgery.
Piquer-Garcia I, Cereijo R, Corral-Pérez J, Pellitero S, Martínez E, Taxerås SD, Tarascó J, Moreno P, Balibrea J, Puig-Domingo M, Serra D, Herrero L, Jiménez-Pavón D, Lerin C, Villarroya F, Sánchez-Infantes D
Obesity surgery 2020
Allicin Regulates Energy Homeostasis through Brown Adipose Tissue.
Zhang C, He X, Sheng Y, Xu J, Yang C, Zheng S, Liu J, Li H, Ge J, Yang M, Zhai B, Xu W, Luo Y, Huang K
iScience 2020
Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo
Markan KR, Boland LK, King-McAlpin AQ, Claflin KE, Leaman MP, Kemerling MK, Stonewall MM, Amendt BA, Ankrum JA, Potthoff MJ
Molecular Metabolism 2020
Functions of Circular RNAs in Regulating Adipogenesis of Mesenchymal Stem Cells
Wang F, Li X, Li Z, Wang S, Fan J
Stem Cells International 2020
DNA Methylation Changes are Associated with the Programming of White Adipose Tissue Browning Features by Resveratrol and Nicotinamide Riboside Neonatal Supplementations in Mice
Serrano A, Asnani-Kishnani M, Couturier C, Astier J, Palou A, Landrier JF, Ribot J, Bonet ML
Nutrients 2020
PPARγ and PPARα synergize to induce robust browning of white fat in vivo
Kroon T, Harms M, Maurer S, Bonnet L, Alexandersson I, Lindblom A, Ahnmark A, Nilsson D, Gennemark P, O'Mahony G, Osinski V, McNamara C, Boucher J
Molecular Metabolism 2020
How does your fat affect your liver when you drink?
Seonghwan Hwang, Bin Gao
Journal of Clinical Investigation 2019
Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans
L Wu, M Xia, Y Duan, L Zhang, H Jiang, X Hu, H Yan, Y Zhang, Y Gu, H Shi, J Li, X Gao, J Li
Cell Death and Disease 2019
Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue
LY Chia, BA Evans, S Mukaida, T Bengtsson, DS Hutchinson, M Sato
British Journal of Pharmacology 2019
The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression
Corrêa, Heyn, Magalhaes
Cells 2019
Cytokines and Abnormal Glucose and Lipid Metabolism
J Shi, J Fan, Q Su, Z Yang
Frontiers in Endocrinology 2019
Neuroendocrine Regulation of Energy Metabolism Involving Different Types of Adipose Tissues
Q Zhu, BJ Glazier, BC Hinkel, J Cao, L Liu, C Liang, H Shi
International journal of molecular sciences 2019
Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism
C Scheele, C Wolfrum
Endocrine reviews 2019
Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging
T Mau, M OBrien, AK Ghosh, RA Miller, R Yung, DL Couteur
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2019
Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome
LI Arhire, L Mihalache, M Covasa
Frontiers in Endocrinology 2019
Rosiglitazone remodels the lipid droplet and britens human visceral and subcutaneous adipocytes ex vivo
MJ Lee, S Jash, JE Jones, V Puri, SK Fried
Journal of lipid research 2019
The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases
Lee, Park, Oh, Lee, Kim, Bae
International journal of molecular sciences 2019
Consumption of out-of-season orange modulates fat accumulation, morphology and gene expression in the adipose tissue of Fischer 344 rats
A Gibert-Ramos, H Palacios-Jordan, MJ Salvadó, A Crescenti
European Journal of Nutrition 2019
A Lipophilic Fucoxanthin-Rich Phaeodactylum tricornutum Extract Ameliorates Effects of Diet-Induced Obesity in C57BL/6J Mice
A Gille, B Stojnic, F Derwenskus, A Trautmann, U Schmid-Staiger, C Posten, K Briviba, A Palou, M Bonet, J Ribot
Nutrients 2019
Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice
L Zhao, B Wang, NA Gomez, JM de Avila, MJ Zhu, M Du
International Journal of Obesity 2019
Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue: Exercise, nutrition and the circadian clock
L Dollet, JR Zierath
The Journal of Physiology 2019
Neonatal Resveratrol and Nicotinamide Riboside Supplementations Sex-Dependently Affect Beige Transcriptional Programming of Preadipocytes in Mouse Adipose Tissue
M Asnani-Kishnani, AM Rodríguez, A Serrano, A Palou, ML Bonet, J Ribot
Frontiers in physiology 2019
Trans-Cinnamic Acid Stimulates White Fat Browning and Activates Brown Adipocytes
N Kang, S Mukherjee, J Yun
Nutrients 2019
3,5 Diiodo-l-Thyronine (T2) Promotes the Browning of White Adipose Tissue in High-Fat Diet-Induced Overweight Male Rats Housed at Thermoneutrality
R Senese, F Cioffi, RD Matteis, G Petito, P de Lange, E Silvestri, A Lombardi, M Moreno, F Goglia, A Lanni
Cells 2019
The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity
M Namwanje, L Liu, M Chan, N Aaron, MJ Kraakman, L Qiang
Journal of Endocrinology 2019
Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells
NZ Jespersen, A Feizi, ES Andersen, S Heywood, HB Hattel, S Daugaard, L Peijs, P Bagi, B Feldt-Rasmussen, HS Schultz, NS Hansen, R Krogh-Madsen, BK Pedersen, N Petrovic, S Nielsen, C Scheele
Molecular Metabolism 2019
Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration
JA Deis, H Guo, Y Wu, C Liu, DA Bernlohr, X Chen
Molecular Metabolism 2019
Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures
S Muller, I Ader, J Creff, H Leménager, P Achard, L Casteilla, L Sensebé, A Carrière, F Deschaseaux
Scientific Reports 2019
Identification of a natural beige adipose depot in mice
M Chan, YC Lim, J Yang, M Namwanje, L Liu, L Qiang
The Journal of biological chemistry 2019
Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis
X Zeng, M Ye, JM Resch, MP Jedrychowski, B Hu, BB Lowell, DD Ginty, BM Spiegelman
Nature 2019
Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway
J Wang, J Ge, H Cao, X Zhang, Y Guo, X Li, B Xia, G Yang, X Shi
Cells 2019
Adrenoceptors in white, brown, and brite adipocytes
BA Evans, J Merlin, T Bengtsson, DS Hutchinson
British Journal of Pharmacology 2019
Ca 2+ entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex
A Schaar, Y Sun, P Sukumaran, TA Rosenberger, D Krout, JN Roemmich, L Brinbaumer, K Claycombe-Larson, BB Singh
Journal of cell science 2019
Resting Energy Expenditure, Insulin Resistance and UCP1 Expression in Human Subcutaneous and Visceral Adipose Tissue of Patients With Obesity
S Bettini, F Favaretto, C Compagnin, A Belligoli, M Sanna, R Fabris, R Serra, CD Prà, L Prevedello, M Foletto, R Vettor, G Milan, L Busetto
Frontiers in Endocrinology 2019
PRDM16 Represses the Pig White Lipogenesis through Promoting Lipolysis Activity
T Gu, G Xu, C Jiang, L Hou, Z Wu, C Wang
BioMed Research International 2019
Dynamics of transcriptome changes during subcutaneous preadipocyte differentiation in ducks
Z Wang, ZT Yin, F Zhang, XQ Li, SR Chen, N Yang, TE Porter, Z Hou
BMC Genomics 2019
Cold-induced lipid dynamics and transcriptional programs in white adipose tissue
Z Xu, W You, Y Zhou, W Chen, Y Wang, T Shan
BMC Biology 2019
Cellular Origins of Beige Fat Cells Revisited
M Shao, QA Wang, A Song, L Vishvanath, NC Busbuso, PE Scherer, RK Gupta
Diabetes 2019
Activation of NPRs and UCP1-independent pathway following CB1R antagonist treatment is associated with adipose tissue beiging in fat-fed male dogs
MS Iyer, RL Paszkiewicz, RN Bergman, JM Richey, OO Woolcott, I Asare-Bediako, Q Wu, SP Kim, D Stefanovski, CM Kolka, DJ Clegg, M Kabir
American journal of physiology. Endocrinology and metabolism 2019
Cold Induced Depot-Specific Browning in Ferret Aortic Perivascular Adipose Tissue
B Reynés, EM van Schothorst, J Keijer, E Ceresi, P Oliver, A Palou
Frontiers in physiology 2019
Gain of Metabolic Benefit with Ablation of miR-149-3p from Subcutaneous Adipose Tissue in Diet-Induced Obese Mice
S Zheng, S Guo, G Sun, Y Shi, Z Wei, Y Tang, F He, C Shi, P Dai, H Chong, I Samuelson, K Zen, CY Zhang, Y Zhang, J Li, X Jiang
Molecular Therapy — Nucleic Acids 2019
Bitter Orange (Citrus aurantium Linné) Improves Obesity by Regulating Adipogenesis and Thermogenesis through AMPK Activation
Park, Kim, Jung, Ahn, Kwak, Um
Nutrients 2019
Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy
CR Dechandt, GD Ferrari, JR dos Santos, JA de Oliveira, RM da Silva-Jr, AO Cunha, N Garcia-Cairasco, LC Alberici
Frontiers in neurology 2019
Reaffirmation of known major genes and the identification of novel candidate genes associated with carcass-related metrics based on whole genome sequence within a large multi-breed cattle population
DC Purfield, RD Evans, DP Berry
BMC Genomics 2019
Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice
H Li, C Zhang, J Liu, W Xie, W Xu, F Liang, K Huang, X He, K Sun
PloS one 2019
Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway
W Sun, X Zhao, Z Wang, Y Chu, L Mao, S Lin, X Gao, Y Song, X Hui, S Jia, S Tang, Y Xu, A Xu, K Loomes, C Wang, D Wu, T Nie
Molecular Metabolism 2019
Myricanol modulates skeletal muscle–adipose tissue crosstalk to alleviate high‐fat diet‐induced obesity and insulin resistance
S Shen, Q Liao, T Zhang, R Pan, L Lin
British Journal of Pharmacology 2019
A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate
W Wang, J Ishibashi, S Trefely, M Shao, AJ Cowan, A Sakers, HW Lim, S OConnor, MT Doan, P Cohen, JA Baur, MT King, RL Veech, KJ Won, JD Rabinowitz, NW Snyder, RK Gupta, P Seale
Cell Metabolism 2019
Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice
YC Jung, HW Kim, BK Min, JY Cho, HJ Son, JY Lee, JY Kim, SB Kwon, Q Li, HW Lee
In vivo (Athens, Greece) 2019
Towards a Better Understanding of Beige Adipocyte Plasticity
E Paulo, B Wang
Cells 2019
Black Ginseng and Ginsenoside Rb1 Promote Browning by Inducing UCP1 Expression in 3T3-L1 and Primary White Adipocytes
SJ Park, M Park, A Sharma, K Kim, HJ Lee
Nutrients 2019
White Adipocyte Plasticity in Physiology and Disease
E Bielczyk-Maczynska
Cells 2019
ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice
L Wei, M Surma, Y Yang, S Tersey, J Shi
The FASEB Journal 2019
MicroRNA‐188 regulates aging‐associated metabolic phenotype
Y Huang, Y Xiao, Y Liu, M Guo, Q Guo, F Zhou, T Liu, T Su, Y Xiao, XH Luo
Aging Cell 2019
QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity
H Lu, Z Ye, Y Zhai, L Wang, Y Liu, J Wang, W Zhang, W Luo, Z Lu, J Chen
EMBO reports 2019
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
RR Stine, AP Sakers, T TeSlaa, M Kissig, ZE Stine, CW Kwon, L Cheng, HW Lim, KH Kaestner, JD Rabinowitz, P Seale
Cell Stem Cell 2019
Relationships between expression levels of genes related to adipogenesis and adipocyte function in dogs.
Motomura M, Shimokawa F, Kobayashi T, Yamashita Y, Mizoguchi I, Sato Y, Murakami Y, Shimizu I, Matsui T, Murakami M, Funaba M
Molecular Biology Reports 2019
CD8+ T cells in beige adipogenesis and energy homeostasis
Maria Moysidou, Sevasti Karaliota, Elisavet Kodela, Maria Salagianni, yassemi koutmani, Antonia Katsouda, Konstantia Kodela, Panagiotis Tsakanikas, Styliani Ourailidou, Evangelos Andreakos, Nikos Kostomitsopoulos, Dimitris Skokos, Antonios Chatzigeorgiou, Kyoung-Jin Chung, Stefan Bornstein, Mark Sleeman, Triantafyllos Chavakis, katia karalis
JCI Insight 2018
Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A
K Ueda, E Takimoto, Q Lu, P Liu, N Fukuma, Y Adachi, R Suzuki, S Chou, W Baur, MJ Aronovitz, AS Greenberg, I Komuro, RH Karas
Diabetes 2018
miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity
EH Koh, N Chernis, PK Saha, L Xiao, DA Bader, B Zhu, K Rajapakshe, MP Hamilton, X Liu, D Perera, , B York, M Trauner, C Coarfa, M Bajaj, DD Moore, T Deng, SE McGuire, SM Hartig
Diabetes 2018
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism
P Pathak, C Xie, RG Nichols, JM Ferrell, S Boehme, KW Krausz, AD Patterson, FJ Gonzalez, JY Chiang
Hepatology 2018
Adipose tissue and the physiologic underpinnings of metabolic disease
RW O'Rourke
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2018
CDK6 inhibits white to beige fat transition by suppressing RUNX1
X Hou, Y Zhang, W Li, AJ Hu, C Luo, W Zhou, JK Hu, SG Daniele, J Wang, J Sheng, Y Fan, AS Greenberg, SR Farmer, MG Hu
Nature Communications 2018
PVAT and Its Relation to Brown, Beige, and White Adipose Tissue in Development and Function
S Hildebrand, J Stümer, A Pfeifer
Frontiers in physiology 2018
Transcriptional Control of Brown and Beige Fat Development and Function: Beige Fat Development and Function
SN Shapira, P Seale
Obesity 2018
Brown Adipose Tissue
A Pfeifer, M Klingenspor, S Herzig
2018
Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity
MT Rached, SJ Millership, SM Pedroni, AI Choudhury, AS Costa, DG Hardy, JA Glegola, EE Irvine, C Selman, MC Woodberry, VK Yadav, S Khadayate, A Vidal-Puig, S Virtue, C Frezza, DJ Withers
Molecular Metabolism 2018
Electric stimulation of ears accelerates body weight loss mediated by high-fat to low-fat diet switch accompanied by increased white adipose tissue browning in C57BL/6 J mice
SH Chen, HC Chen, CL Hsieh, PM Chao
BMC complementary and alternative medicine 2018
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance
B Wang, K Cheng
International journal of molecular sciences 2018
Wnt/β-Catenin Signaling and Obesity
N Chen, J Wang
Frontiers in physiology 2018
Perivascular Adipose Tissue as a Relevant Fat Depot for Cardiovascular Risk in Obesity
RM Costa, KB Neves, RC Tostes, NS Lobato
Frontiers in physiology 2018
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation
Y Igarashi, A Nawaz, T Kado, M Bilal, T Kuwano, S Yamamoto, M Sasahara, X Jiuxiang, A Inujima, K Koizumi, J Imura, N Shibahara, I Usui, S Fujisaka, K Tobe
Scientific Reports 2018
Development, activation, and therapeutic potential of thermogenic adipocytes
MP Emont, D Kim, J Wu
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2018
Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning
J Han, Q Meng, L Shen, G Wu
Lipids in Health and Disease 2018
Looking on the “brite” side exercise-induced browning of white adipose tissue
LK Townsend, DC Wright
Pflügers Archiv - European Journal of Physiology 2018
Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity
E Paulo, D Wu, P Hecker, Y Zhang, B Wang
Journal of Endocrinology 2018
HDAC3-selective inhibition activates brown and beige fat through PRDM16
J Liao, J Jiang, H Jun, X Qiao, MP Emont, D Kim, J Wu
Endocrinology 2018
Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis
Y Hasegawa, K Ikeda, Y Chen, DL Alba, D Stifler, K Shinoda, T Hosono, P Maretich, Y Yang, Y Ishigaki, J Chi, P Cohen, SK Koliwad, S Kajimura
Cell Metabolism 2018
Functional role of ADAMTS5 in adiposity and metabolic health
D Bauters, P Bedossa, HR Lijnen, B Hemmeryckx, V Souza-Mello
PloS one 2018
Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans
M Stadion, K Schwerbel, A Graja, C Baumeier, M Rödiger, W Jonas, C Wolfrum, H Staiger, A Fritsche, HU Häring, N Klöting, M Blüher, P Fischer-Posovszky, TJ Schulz, HG Joost, H Vogel, A Schürmann
Diabetologia 2018
Dendritic peptide bolaamphiphiles for siRNA delivery to primary adipocytes
AC Eldredge, ME Johnson, Y Cao, L Zhang, C Zhao, Z Liu, Q Yang, Z Guan
Biomaterials 2018
Metabolic benefits of inhibition of p38α in white adipose tissue in obesity
S Zhang, H Cao, Y Li, Y Jing, S Liu, C Ye, H Wang, S Yu, C Peng, L Hui, Y Wang, H Zhang, F Guo, Q Zhai, H Wang, R Huang, L Zhang, J Jiang, W Liu, H Ying, G Hotamisligil
PLoS Biology 2018
Derivation and characterization of a UCP1 reporter human ES cell line
S Mukherjee, T Zhang, LA Lacko, L Tan, JZ Xiang, JM Butler, S Chen
Stem Cell Research 2018
The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting
S Elattar, M Dimri, A Satyanarayana
The FASEB Journal 2018
Rosiglitazone and a β3-Adrenoceptor Agonist Are Both Required for Functional Browning of White Adipocytes in Culture
J Merlin, M Sato, LY Chia, R Fahey, M Pakzad, CJ Nowell, RJ Summers, T Bengtsson, BA Evans, DS Hutchinson
Frontiers in Endocrinology 2018
Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis
Q Chen, L Huang, D Pan, LJ Zhu, YX Wang
Cell Reports 2018
Molecular signatures and functional analysis of beige adipocytes induced from in vivo intra-abdominal adipocytes
H Xue, Z Wang, Y Hua, S Ke, Y Wang, J Zhang, YH Pan, W Huang, DM Irwin, S Zhang
Science Advances 2018
TGF-β receptor 1 regulates progenitors that promote browning of white fat
UD Wankhade, JH Lee, PK Dagur, H Yadav, M Shen, W Chen, AB Kulkarni, JP McCoy, T Finkel, AM Cypess, SG Rane
Molecular Metabolism 2018
Genetic and epigenetic control of adipose development
O Gulyaeva, J Dempersmier, HS Sul
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2018
PRDM16 Gene Polymorphism Is Associated with Obesity and Blood Lipids Profiles in Saudi Population
A AlAmrani, M AbdelKarim, M AlZoghaibi
Journal of Clinical Medicine 2018
cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis
YS Yoon, WW Tsai, SV de Velde, Z Chen, KF Lee, DA Morgan, K Rahmouni, S Matsumura, E Wiater, Y Song, M Montminy
Proceedings of the National Academy of Sciences 2018
PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice
NJ Song, SH Chang, S Kim, V Panic, BH Jang, UJ Yun, JH Choi, Z Li, KM Park, JH Yoon, S Kim, JH Yoo, J Ling, K Thomas, CJ Villanueva, DY Li, JY Ahn, JM Ku, KW Park
Cell Death and Disease 2018
Assessment of the Aging of the Brown Adipose Tissue by 18 F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna −/−
Z Wang, X Xu, Y Liu, Y Gao, F Kang, B Liu, J Wang
Contrast Media & Molecular Imaging 2018
Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1
T Zou, B Wang, Q Yang, JM de Avila, MJ Zhu, J You, D Chen, M Du
The Journal of Nutritional Biochemistry 2018
The Common and Distinct Features of Brown and Beige Adipocytes
K Ikeda, P Maretich, S Kajimura
Trends in endocrinology and metabolism: TEM 2018
Crotamine induces browning of adipose tissue and increases energy expenditure in mice
MP Marinovic, JD Campeiro, SC Lima, AL Rocha, MB Nering, EB Oliveira, MA Mori, MA Hayashi
Scientific Reports 2018
Brown Adipose Tissue Energy Metabolism in Humans
AC Carpentier, DP Blondin, KA Virtanen, D Richard, F Haman, ÉE Turcotte
Frontiers in Endocrinology 2018
Expression levels of brown/beige adipocyte-related genes in fat depots of vitamin A-restricted fattening cattle1
HJ Chen, T Ihara, H Yoshioka, E Itoyama, S Kitamura, H Nagase, H Murakami, Y Hoshino, M Murakami, S Tomonaga, T Matsui, M Funaba
Journal of animal science 2018
The nuclear retinoid-related orphan receptor ROR α controls circadian thermogenic programming in white fat depots
C Monnier, M Auclair, GL Cam, MP Garcia, B Antoine
Physiological Reports 2018
Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex
X Ma, D Wang, W Zhao, L Xu
Frontiers in Endocrinology 2018
Class I and II Histone Deacetylase Inhibitors Differentially Regulate Thermogenic Gene Expression in Brown Adipocytes
A Rajan, H Shi, B Xue
Scientific Reports 2018
Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway
JS Samuels, R Shashidharamurthy, S Rayalam
Nutrition & Metabolism 2018
Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration
Q Li, Y Wu, N Kang
Stem Cells International 2018
Insights into the neurochemical signature of the Innervation of Beige Fat
A Stefanidis, NM Wiedmann, S Tyagi, AM Allen, MJ Watt, BJ Oldfield
Molecular Metabolism 2018
Association of serum concentrations of irisin and the adipokines adiponectin and leptin with epicardial fat in cardiovascular surgery patients
H Kaneda, T Nakajima, A Haruyama, I Shibasaki, T Hasegawa, T Sawaguchi, T Kuwata, S Obi, T Arikawa, M Sakuma, H Amano, S Toyoda, H Fukuda, T Inoue, L Vanella
PloS one 2018
Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes
K Lee, YJ Seo, JH Song, BY Lee
Journal of Ginseng Research 2018
Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes
DF Pisani, V Barquissau, JC Chambard, D Beuzelin, RA Ghandour, M Giroud, A Mairal, S Pagnotta, S Cinti, D Langin, EZ Amri
Molecular Metabolism 2018
Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes
VD Ramseyer, VA Kimler, JG Granneman
Molecular Metabolism 2018
Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway
X Zhang, Y Luo, C Wang, X Ding, X Yang, D Wu, F Silva, Z Yang, Q Zhou, L Wang, X Wang, J Zhou, N Boyd, M Spafford, M Burge, XO Yang, M Liu
Cell Reports 2018
The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice
K Takeda, H Sawazaki, H Takahashi, YS Yeh, HF Jheng, W Nomura, T Ara, N Takahashi, S Seno, N Osato, H Matsuda, T Kawada, T Goto
FEBS Open Bio 2018
Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes
A Kaisanlahti, T Glumoff
Journal of Physiology and Biochemistry 2018
Thermal stress induces glycolytic beige fat formation via a myogenic state
Y Chen, K Ikeda, T Yoneshiro, A Scaramozza, K Tajima, Q Wang, K Kim, K Shinoda, CH Sponton, Z Brown, A Brack, S Kajimura
Nature 2018
Genome-wide identification and characterization of long non-coding RNAs during postnatal development of rabbit adipose tissue
GZ Wang, K Du, SQ Hu, SY Chen, XB Jia, MC Cai, Y Shi, J Wang, SJ Lai
Lipids in Health and Disease 2018
Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue
V Pellegrinelli, VJ Peirce, L Howard, S Virtue, D Türei, M Senzacqua, A Frontini, JW Dalley, AR Horton, G Bidault, I Severi, A Whittle, K Rahmouni, J Saez-Rodriguez, S Cinti, AM Davies, A Vidal-Puig
Nature Communications 2018
Deletion of p22phox-dependent oxidative stress in the hypothalamus protects against obesity by modulating β3-adrenergic mechanisms
Heinrich Lob, Jiunn Song, Chansol Hurr, Alvin Chung, Colin Young, Allyn L Mark, Robin Davisson
JCI Insight 2017
Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions
Xiaoyan Yang, Wenhai Sui, Meng Zhang, Mei Dong, Sharon Lim, Takahiro Seki, Ziheng Guo, Carina Fischer, Huixia Lu, Cheng Zhang, Jianmin Yang, Meng Zhang, Yangang Wang, Caixia Cao, Yanyan Gao, Xingguo Zhao, Meili Sun, Yuping Sun, Rujie Zhuang, Nilesh Samani, Yun Zhang, Yihai Cao
JCI Insight 2017
Comparing minimally supervised home-based and closely supervised gym-based exercise programs in weight reduction and insulin resistance after bariatric surgery: A randomized clinical trial
S Kaviani, H Dadgostar, A Mazaherinezhad, H Adib, M Solaymani-Dodaran, F Soheilipour, M Hakiminezhad
Medical journal of the Islamic Republic of Iran 2017
White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
YW Chung, F Ahmad, Y Tang, SC Hockman, HJ Kee, K Berger, E Guirguis, YH Choi, DM Schimel, AM Aponte, S Park, E Degerman, VC Manganiello
Scientific Reports 2017
Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice
C Milet, M Bléher, K Allbright, M Orgeur, F Coulpier, D Duprez, E Havis
Scientific Reports 2017
Tissue Immunometabolism: Development, Physiology, and Pathobiology
K Man, VI Kutyavin, A Chawla
Cell Metabolism 2017
Thermogenic Fat
J Wu
Thermogenic Fat 2017
Metabolic regulation and the anti-obesity perspectives of human brown fat
C Scheele, S Nielsen
Redox Biology 2017
Deciphering adipose tissue heterogeneity: Adipose tissue heterogeneity
MD Lynes, YH Tseng
Annals of the New York Academy of Sciences 2017
Shortcuts to a functional adipose tissue: The role of small non-coding RNAs
BB Brandão, BA Guerra, MA Mori
Redox Biology 2017
The dark side of browning
KA Tamucci, M Namwanje, L Fan, L Qiang
Protein & Cell 2017
Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules
NJ Song, SH Chang, DY Li, CJ Villanueva, KW Park
Experimental & molecular medicine 2017
Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into BloodNovelty and Significance
JW Williams, A Elvington, S Ivanov, S Kessler, H Luehmann, O Baba, BT Saunders, KW Kim, MW Johnson, CS Craft, JH Choi, MG Sorci-Thomas, BH Zinselmeyer, JR Brestoff, Y Liu, GJ Randolph
Circulation research 2017
Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function: Exercise, adipose tissue and vascular function
BC Boa, JS Yudkin, VW van Hinsbergh, E Bouskela, EC Eringa
British Journal of Pharmacology 2017
Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice
C Hepler, M Shao, JY Xia, AL Ghaben, MJ Pearson, L Vishvanath, AX Sharma, TS Morley, WL Holland, RK Gupta
eLife 2017
Parkin-mediated mitophagy is downregulated in browning of white adipose tissue: Parkin Downregulation in White Adipose Browning
D Taylor, RA Gottlieb
Obesity 2017
An adaptive variant of TRIB2, rs1057001, is associated with higher expression levels of thermogenic genes in human subcutaneous and visceral adipose tissues
K Nakayama, S Iwamoto
Journal of PHYSIOLOGICAL ANTHROPOLOGY 2017
Sorting out adipocyte precursors and their role in physiology and disease
C Hepler, L Vishvanath, RK Gupta
Genes & development 2017
Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes
N González, Z Moreno-Villegas, A González-Bris, J Egido, Ó Lorenzo
Cardiovascular Diabetology 2017
EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex
SN Shapira, HW Lim, S Rajakumari, AP Sakers, J Ishibashi, MJ Harms, KJ Won, P Seale
Genes & development 2017
Humans and Mice Display Opposing Patterns of “Browning” Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots
MA Zuriaga, JJ Fuster, N Gokce, K Walsh
Frontiers in Cardiovascular Medicine 2017
Lsd1 prevents age-programed loss of beige adipocytes
D Duteil, M Tosic, D Willmann, A Georgiadi, T Kanouni, R Schüle
Proceedings of the National Academy of Sciences 2017
An Additive Effect of Promoting Thermogenic Gene Expression in Mice Adipose-Derived Stromal Vascular Cells by Combination of Rosiglitazone and CL316,243
YL Li, X Li, TT Jiang, JM Fan, XL Zheng, XE Shi, TY Yu, GY Chu, GS Yang
International journal of molecular sciences 2017
Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling
D Bauters, M Cobbaut, L Geys, JV Lint, B Hemmeryckx, HR Lijnen
Molecular Metabolism 2017
Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system
K Kaineder, T Birngruber, G Rauter, B Obermüller, J Eichler, J Münzker, W Al-Zoughbi, SI Mautner, SS Torekov, B Hartmann, P Kotzbeck, TR Pieber
International Journal of Obesity 2017
Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α
Z Song, AM Xiaoli, Q Zhang, Y Zhang, ES Yang, S Wang, R Chang, ZD Zhang, G Yang, R Strich, JE Pessin, F Yang
The Journal of biological chemistry 2017
Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning
M Patil, BK Sharma, S Elattar, J Chang, S Kapil, J Yuan, A Satyanarayana
Diabetes 2017
Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57BL/6 mice
LF Gonçalves, TQ Machado, C Castro-Pinheiro, NG de Souza, KJ Oliveira, C Fernandes-Santos
International Journal of Experimental Pathology 2017
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming
A Guilherme, DJ Pedersen, E Henchey, FS Henriques, LV Danai, Y Shen, B Yenilmez, DY Jung, JK Kim, IJ Lodhi, CF Semenkovich, MP Czech
Molecular Metabolism 2017
Cinnamon induces browning in subcutaneous adipocytes
HY Kwan, J Wu, T Su, XJ Chao, B Liu, X Fu, CL Chan, RH Lau, AK Tse, QB Han, WF Fong, Z Yu
Scientific Reports 2017
Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity
C Jiang, MA Cano-Vega, F Yue, L Kuang, N Narayanan, G Uzunalli, MP Merkel, S Kuang, M Deng
Molecular Therapy 2017
Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
L Huang, D Pan, Q Chen, LJ Zhu, J Ou, M Wabitsch, YX Wang
Nature Communications 2017
Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat
LH Chen, YW Chien, CT Liang, CH Chan, MH Fan, HY Huang
Food & Nutrition Research 2017
Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA
M Lundh, K Plucinska, MS Isidor, PS Petersen, B Emanuelli
Molecular Metabolism 2017
Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice
K Weitkunat, C Stuhlmann, A Postel, S Rumberger, M Fankhänel, A Woting, KJ Petzke, S Gohlke, TJ Schulz, M Blaut, S Klaus, S Schumann
Scientific Reports 2017
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
YE Kang, S Choung, JH Lee, HJ Kim, BJ Ku
Endocrinology and Metabolism 2017
Fifty shades of white: Understanding heterogeneity in white adipose stem cells
L Cleal, T Aldea, YY Chau
Adipocyte 2017
Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression
A Fukunaka, T Fukada, J Bhin, L Suzuki, T Tsuzuki, Y Takamine, BH Bin, T Yoshihara, N Ichinoseki-Sekine, H Naito, T Miyatsuka, S Takamiya, T Sasaki, T Inagaki, T Kitamura, S Kajimura, H Watada, Y Fujitani, GS Barsh
PLoS genetics 2017
Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes
CR Dechandt, FH Zuccolotto-dos-Reis, BG Teodoro, AM Fernandes, MN Eberlin, IC Kettelhut, C Curti, LC Alberici
Journal of Bioenergetics and Biomembranes 2017
Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity
Y Chen, X Zeng, X Huang, S Serag, CJ Woolf, BM Spiegelman
Cell 2017
Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure: A Narrative Review
L Mele, G Bidault, P Mena, A Crozier, F Brighenti, A Vidal-Puig, DD Rio
Advances in nutrition (Bethesda, Md.) 2017
PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing
M Kissig, J Ishibashi, MJ Harms, HW Lim, RR Stine, KJ Won, P Seale
The EMBO Journal 2017
Epigenetic Regulation of the Thermogenic Adipose Program
A Sambeat, O Gulyaeva, J Dempersmier, HS Sul
Trends in Endocrinology & Metabolism 2017
Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates diet-induced obesity
C Jiang, M Zhai, D Yan, D Li, C Li, Y Zhang, L Xiao, D Xiong, Q Deng, W Sun
Oncotarget 2017
Brown Adipose Tissue: an Update on Recent Findings
KL Marlatt, E Ravussin
Current Obesity Reports 2017
UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
K Ikeda, Q Kang, T Yoneshiro, JP Camporez, H Maki, M Homma, K Shinoda, Y Chen, X Lu, P Maretich, K Tajima, KM Ajuwon, T Soga, S Kajimura
Nature Medicine 2017
MicroRNA-27b Depletion Enhances Endotrophic and Intravascular Lipid Accumulation and Induces Adipocyte Hyperplasia in Zebrafish
CC Hsu, CY Lai, CY Lin, KY Yeh, G Her
International journal of molecular sciences 2017
Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice
L Gan, Z Liu, F Feng, T Wu, D Luo, C Hu, C Sun
International Journal of Obesity 2017
Fattening the role of Ca2+ cycling in adaptive thermogenesis.
Gamu D, Tupling AR
Nature Medicine 2017
Thermogenic Profiling using Magnetic Resonance Imaging of Dermal and Other Adipose Tissues
Ildiko Kasza, Diego Hernando, Alejandro Roldán-Alzate, Caroline Alexander, Scott Reeder
JCI Insight 2016
Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice
GY Liu, J Liu, YL Wang, Y Liu, Y Shao, Y Han, YR Qin, FJ Xiao, PF Li, LJ Zhao, EY Gu, SY Chen, LH Gao, CT Wu, XW Hu, HF Duan
Stem Cells Translational Medicine 2016
Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome
MV de Pette, SJ Tunster, GI McNamara, T Shelkovnikova, S Millership, L Benson, S Peirson, M Christian, A Vidal-Puig, RM John, MS Bartolomei
PLoS genetics 2016
A novel thermoregulatory role for PDE10A in mouse and human adipocytes
MK Hankir, M Kranz, T Gnad, J Weiner, S Wagner, W DeutherConrad, F Bronisch, K Steinhoff, J Luthardt, N Klöting, S Hesse, JP Seibyl, O Sabri, JT Heiker, M Blüher, A Pfeifer, P Brust, WK Fenske
EMBO Molecular Medicine 2016
Heterogeneity of white adipose tissue: molecular basis and clinical implications
KH Kwok, KS Lam, A Xu
Experimental & molecular medicine 2016
Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis
EH Koh, Y Chen, DA Bader, MP Hamilton, B He, B York, S Kajimura, SE McGuire, SM Hartig
The Journal of biological chemistry 2016
Brain Regulation of Energy Metabolism
E Roh, MS Kim
Endocrinology and Metabolism 2016
Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis
N Li, Q Yang, RG Walker, TB Thompson, M Du, BD Rodgers
Endocrinology 2016
Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue
CM Tran, S Mukherjee, L Ye, DW Frederick, M Kissig, JG Davis, DW Lamming, P Seale, JA Baur
Diabetes 2016
Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases
A Ferrari, E Fiorino, R Longo, S Barilla, N Mitro, G Cermenati, M Giudici, D Caruso, A Mai, U Guerrini, ED Fabiani, M Crestani
International Journal of Obesity 2016
Brown adipose tissue: The heat is on the heart
R Thoonen, AG Hindle, M Scherrer-Crosbie
American journal of physiology. Heart and circulatory physiology 2016
Adipose tissue in control of metabolism
L Luo, M Liu
Journal of Endocrinology 2016
Cell biology of fat storage
P Cohen, BM Spiegelman
Molecular biology of the cell 2016
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders
SS Choe, JY Huh, IJ Hwang, JI Kim, JB Kim
Frontiers in Endocrinology 2016
Organization of nuclear architecture during adipocyte differentiation
NL Charó, MI Ceschan, NM Galigniana, J Toneatto, G Piwien-Pilipuk
Nucleus 2016
Convertible visceral fat as a therapeutic target to curb obesity
A Giordano, A Frontini, S Cinti
Nature Reviews Drug Discovery 2016
Does bariatric surgery improve adipose tissue function?: Bariatric surgery and adipose tissue
H Frikke-Schmidt, RW O'Rourke, CN Lumeng, DA Sandoval, RJ Seeley
Obesity Reviews 2016
Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism
E Roh, DK Song, MS Kim
Experimental & molecular medicine 2016
White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways
V Barquissau, D Beuzelin, DF Pisani, GE Beranger, A Mairal, A Montagner, B Roussel, G Tavernier, MA Marques, C Moro, H Guillou, EZ Amri, D Langin
Molecular Metabolism 2016
EBF2 promotes the recruitment of beige adipocytes in white adipose tissue
RR Stine, SN Shapira, HW Lim, J Ishibashi, M Harms, KJ Won, P Seale
Molecular Metabolism 2016
Transcriptional and epigenetic control of brown and beige adipose cell fate and function
T Inagaki, J Sakai, S Kajimura
Nature Reviews Molecular Cell Biology 2016
Influencing Factors of Thermogenic Adipose Tissue Activity
G Zhang, Q Sun, C Liu
Frontiers in physiology 2016
GQ-16, a TZD-Derived Partial PPARγ Agonist, Induces the Expression of Thermogenesis-Related Genes in Brown Fat and Visceral White Fat and Decreases Visceral Adiposity in Obese and Hyperglycemic Mice
MS Coelho, CL de Lima, C Royer, JB Silva, FC Oliveira, CG Christ, SA Pereira, SN Bao, MC Lima, MG Pitta, IR Pitta, FA Neves, AA Amato, M Makishima
PloS one 2016
Inter-organ regulation of adipose tissue browning
S Wang, X Yang
Cellular and Molecular Life Sciences 2016
miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity
AD Gaudet, LK Fonken, LV Gushchina, TG Aubrecht, SK Maurya, M Periasamy, RJ Nelson, PG Popovich
Scientific Reports 2016
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro
E Zhu, Y Yang, J Zhang, Y Li, C Li, L Chen, B Sun
Oncotarget 2016
Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16
H Ding, S Zheng, D Garcia-Ruiz, D Hou, Z Wei, Z Liao, L Li, Y Zhang, X Han, K Zen, CY Zhang, J Li, X Jiang
Nature Communications 2016
PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity
B Zhou, J Wang, SY Lee, J Xiong, N Bhanu, Q Guo, P Ma, Y Sun, RC Rao, BA Garcia, JL Hess, Y Dou
Molecular Cell 2016
Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue
UD Wankhade, M Shen, H Yadav, KM Thakali
BioMed Research International 2016
Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance
S Altshuler-Keylin, K Shinoda, Y Hasegawa, K Ikeda, H Hong, Q Kang, Y Yang, RM Perera, J Debnath, S Kajimura
Cell Metabolism 2016
Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice
A Ejaz, L Martinez-Guino, AB Goldfine, F Ribas-Aulinas, VD Nigris, S Ribó, A Gonzalez-Franquesa, PM Garcia-Roves, E Li, JM Dreyfuss, W Gall, JK Kim, T Bottiglieri, F Villarroya, RE Gerszten, ME Patti, C Lerin
Diabetes 2016
miRNA regulation of white and brown adipose tissue differentiation and function
NL Price, C Fernández-Hernando
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2016
Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity
Y Chen, JJ Buyel, MJ Hanssen, F Siegel, R Pan, J Naumann, M Schell, A der Lans, C Schlein, H Froehlich, J Heeren, KA Virtanen, WM Lichtenbelt, A Pfeifer
Nature Communications 2016
Control of brown and beige fat development
W Wang, P Seale
Nature Reviews Molecular Cell Biology 2016
Artepillin C, a Typical Brazilian Propolis-Derived Component, Induces Brown-Like Adipocyte Formation in C3H10T1/2 Cells, Primary Inguinal White Adipose Tissue-Derived Adipocytes, and Mice
S Nishikawa, H Aoyama, M Kamiya, J Higuchi, A Kato, M Soga, T Kawai, K Yoshimura, S Kumazawa, T Tsuda, H Xu
PloS one 2016
A novel combined glucocorticoid-mineralocorticoid receptor selective modulator markedly prevents weight gain and fat mass expansion in mice fed a high-fat diet
C Mammi, V Marzolla, A Armani, A Feraco, A Antelmi, E Maslak, S Chlopicki, F Cinti, H Hunt, A Fabbri, M Caprio
International Journal of Obesity 2016
A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis
K Ohyama, Y Nogusa, K Shinoda, K Suzuki, M Bannai, S Kajimura
Diabetes 2016
The critical period for brown adipocyte development: Genetic and environmental influences: Brown Adipocyte Development
A Chabowska-Kita, LP Kozak
Obesity 2016
Genetic backgrounds determine brown remodeling of white fat in rodents
G Ferrannini, M Namwanje, B Fang, M Damle, D Li, Q Liu, MA Lazar, L Qiang
Molecular Metabolism 2016
ASK1 signalling regulates brown and beige adipocyte function
K Hattori, I Naguro, K Okabe, T Funatsu, S Furutani, K Takeda, H Ichijo
Nature Communications 2016
Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans
A Gavaldà-Navarro, JM Moreno-Navarrete, T Quesada-López, M Cairó, M Giralt, JM Fernández-Real, F Villarroya
Diabetologia 2016
Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice
S Hanatani, H Motoshima, Y Takaki, S Kawasaki, M Igata, T Matsumura, T Kondo, T Senokuchi, N Ishii, J Kawashima, D Kukidome, S Shimoda, T Nishikawa, E Araki
Journal of Clinical Biochemistry and Nutrition 2016
Intermedin/adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice
H Zhang, SY Zhang, C Jiang, Y Li, G Xu, MJ Xu, X Wang
International Journal of Obesity 2016
The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria
JZ Long, KJ Svensson, LA Bateman, H Lin, T Kamenecka, IA Lokurkar, J Lou, RR Rao, MR Chang, MP Jedrychowski, JA Paulo, SP Gygi, PR Griffin, DK Nomura, BM Spiegelman
Cell 2016
Cannabidiol promotes browning in 3T3-L1 adipocytes
HA Parray, JW Yun
Molecular and Cellular Biochemistry 2016
Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice
TN Bukong, A Iracheta-Vellve, B Gyongyosi, A Ambade, D Catalano, K Kodys, G Szabo
Alcoholism Clinical and Experimental Research 2016
Marrow Adipose Tissue: Trimming the Fat
EL Scheller, WP Cawthorn, AA Burr, MC Horowitz, OA MacDougald
Trends in Endocrinology & Metabolism 2016
Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders
SH Kim, J Plutzky
Diabetes & Metabolism Journal 2016
Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture
X Qin, HG Park, JY Zhang, P Lawrence, G Liu, N Subramanian, KS Kothapalli, JT Brenna
Prostaglandins, Leukotrienes and Essential Fatty Acids 2016
Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
T Shan, Y Xiong, P Zhang, Z Li, Q Jiang, P Bi, F Yue, G Yang, Y Wang, X Liu, S Kuang
Nature Communications 2016
Browning and Graying: Novel Transcriptional Regulators of Brown and Beige Fat Tissues and Aging
E Mueller
Frontiers in Endocrinology 2016
ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs
MH Lee, AG Goralczyk, R Kriszt, XM Ang, C Badowski, Y Li, SA Summers, SA Toh, MS Yassin, A Shabbir, A Sheppard, M Raghunath
Scientific Reports 2016
Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals
Y Zhu, Y Gao, C Tao, M Shao, S Zhao, W Huang, T Yao, JA Johnson, T Liu, AM Cypess, O Gupta, WL Holland, RK Gupta, DC Spray, HB Tanowitz, L Cao, MD Lynes, YH Tseng, JK Elmquist, KW Williams, HV Lin, PE Scherer
Cell Metabolism 2016
Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program
M Shao, J Ishibashi, CM Kusminski, QA Wang, C Hepler, L Vishvanath, KA MacPherson, SB Spurgin, K Sun, WL Holland, P Seale, RK Gupta
Cell Metabolism 2016
FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle
BM Varela-Rodríguez, L Pena-Bello, P Juiz-Valiña, B Vidal-Bretal, F Cordido, S Sangiao-Alvarellos
Scientific Reports 2016
Monoterpene phenolic compound thymol promotes browning of 3T3-L1 adipocytes
JH Choi, SW Kim, R Yu, JW Yun
European Journal of Nutrition 2016
The Mechanism by Which Safflower Yellow Decreases Body Fat Mass and Improves Insulin Sensitivity in HFD-Induced Obese Mice
H Zhu, X Wang, H Pan, Y Dai, N Li, L Wang, H Yang, F Gong
Frontiers in pharmacology 2016
A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function
KJ Svensson, JZ Long, MP Jedrychowski, P Cohen, JC Lo, S Serag, S Kir, K Shinoda, JA Tartaglia, RR Rao, A Chédotal, S Kajimura, SP Gygi, BM Spiegelman
Cell Metabolism 2016
Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate
M Sahuri-Arisoylu, LP Brody, JR Parkinson, H Parkes, N Navaratnam, AD Miller, EL Thomas, G Frost, JD Bell
International Journal of Obesity 2016
Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation
X Zeng, MP Jedrychowski, Y Chen, S Serag, GG Lavery, SP Gygi, BM Spiegelman
Genes & development 2016
Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss
A Nakhuda, AR Josse, V Gburcik, H Crossland, F Raymond, S Metairon, L Good, PJ Atherton, SM Phillips, JA Timmons
The American journal of clinical nutrition 2016
Coordinate mobilization and burning of lipid stores . Focus on “Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health”
MJ Brady
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2016
Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα
M Yan, É Audet-Walsh, S Manteghi, CR Dufour, B Walker, M Baba, J St-Pierre, V Giguère, A Pause
Genes & development 2016
Editorial: Unlocking Therapeutic Potential of Brown Fat
RS Ahima
Molecular Endocrinology 2016
Circulating Adipocyte Fatty Acid Binding Protein (FABP4) Levels Are Associated with Irisin in the Middle-Aged General Chinese Population
S Zhang, L Yang, P Chen, H Jin, X Xie, M Yang, T Gao, C Hu, X Yu, ML Hribal
PloS one 2016
The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment
C Hepler, RK Gupta
Molecular and Cellular Endocrinology 2016
Distinct functions of PPARγ isoforms in regulating adipocyte plasticity
D Li, F Zhang, X Zhang, C Xue, M Namwanje, L Fan, MP Reilly, F Hu, L Qiang
Biochemical and Biophysical Research Communications 2016
Metabolic programming of a beige adipocyte phenotype by genistein
SA Aziz, LA Wakeling, S Miwa, G Alberdi, JE Hesketh, D Ford
Molecular Nutrition & Food Research 2016
Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis
R Brunmeir, J Wu, X Peng, SY Kim, SG Julien, Q Zhang, W Xie, F Xu, C Wolfrum
PLoS genetics 2016
Clozapine modifies the differentiation program of human adipocytes inducing browning
E Kristóf, QM Doan-Xuan, AK Sárvári, Á Klusóczki, P Fischer-Posovszky, M Wabitsch, Z Bacso, P Bai, Z Balajthy, L Fésüs
Translational Psychiatry 2016
Original Research: Hydroxytyrosol, an ingredient of olive oil, reduces triglyceride accumulation and promotes lipolysis in human primary visceral adipocytes during differentiation
B Stefanon, M Colitti
Experimental biology and medicine (Maywood, N.J.) 2016
Thermoneutrality decreases thermogenic program and promotes adiposity in high-fat diet-fed mice
X Cui, NL Nguyen, E Zarebidaki, Q Cao, F Li, L Zha, T Bartness, H Shi, B Xue
Physiological Reports 2016
Direct lentivirus injection for fast and efficient gene transfer into brown and beige adipose tissue
A Balkow, LS Hoffmann, K Klepac, A Glöde, T Gnad, K Zimmermann, A Pfeifer
Journal of Biological Methods 2016
AT1 receptor antagonist induces thermogenic beige adipocytes in the inguinal white adipose tissue of obese mice.
Graus-Nunes F, Rachid TL, de Oliveira Santos F, Barbosa-da-Silva S, Souza-Mello V
Endocrine 2016
Brown and Beige Fat in Humans: Thermogenic adipocytes that control energy and glucose homeostasis
Labros Siddossis, Shingo Kajimura
Journal of Clinical Investigation 2015
Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance
AL Poher, J Altirriba, C Veyrat-Durebex, FÃ Rohner-Jeanrenaud
Frontiers in physiology 2015
Transcriptional control and hormonal response of thermogenic fat
MP Emont, H Yu, J Wu
Journal of Endocrinology 2015
Formation and activation of thermogenic fat
J Wu, H Jun, JR McDermott
Trends in Genetics 2015
The miRNA Interactome in Metabolic Homeostasis
SM Hartig, MP Hamilton, DA Bader, SE McGuire
Trends in Endocrinology & Metabolism 2015
Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat
GT Dodd, S Decherf, K Loh, SE Simonds, F Wiede, E Balland, TL Merry, H Münzberg, ZY Zhang, BB Kahn, BG Neel, KK Bence, ZB Andrews, MA Cowley, T Tiganis
Cell 2015
Adipose VEGF links the white-to-brown fat switch with environmental, genetic, and pharmacological stimuli in male mice
MJ During, X Liu, W Huang, D Magee, A Slater, T McMurphy, C Wang, L Cao
Endocrinology 2015
Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation
P Seale
Diabetes 2015
Ubc9 impairs activation of the brown fat energy metabolism program in human white adipocytes
SM Hartig, DA Bader, KV Abadie, M Motamed, MP Hamilton, W Long, B York, M Mueller, M Wagner, M Trauner, L Chan, M Bajaj, DD Moore, MA Mancini, SE McGuire
Molecular Endocrinology 2015
Hydrogel-based engineering of beige adipose tissue
MK Vaicik, M Morse, A Blagajcevic, J Rios, JC Larson, F Yang, RN Cohen, G Papavasiliou, EM Brey
Journal of Materials Chemistry B 2015
Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice
N Douris, DM Stevanovic, M Fisher, TI Cisu, MJ Chee, NL Nguyen, E Zarebidaki, AC Adams, A Kharitonenkov, JS Flier, TJ Bartness, E Maratos-Flier
Endocrinology 2015
A metabolomic study of adipose tissue in mice with a disruption of the circadian system
C Castro, W Briggs, GK Paschos, GA FitzGerald, JL Griffin
Molecular BioSystems 2015
Adipose Tissue-Residing Progenitors (Adipocyte Lineage Progenitors and Adipose-Derived Stem Cells (ADSC))
R Berry, MS Rodeheffer, CJ Rosen, MC Horowitz
Current Molecular Biology Reports 2015
The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation
L Zha, F Li, R Wu, L Artinian, V Rehder, L Yu, H Liang, B Xue, H Shi
The Journal of biological chemistry 2015
Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations
KI Stanford, RJ Middelbeek, LJ Goodyear
Diabetes 2015
Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure
K Shinoda, K Ohyama, Y Hasegawa, HY Chang, M Ogura, A Sato, H Hong, T Hosono, LZ Sharp, DW Scheel, M Graham, Y Ishihama, S Kajimura
Cell Metabolism 2015
PTHrp comes full circle in cancer biology
AR Guntur, CR Doucette, CJ Rosen
BoneKEy Reports 2015
A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis
KI Stanford, RJ Middelbeek, KL Townsend, MY Lee, H Takahashi, K So, KM Hitchcox, KR Markan, K Hellbach, MF Hirshman, YH Tseng, LJ Goodyear
Diabetes 2015
Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers
HY Kwan, X Niu, W Dai, T Tong, X Chao, T Su, CL Chan, KC Lee, X Fu, H Yi, H Yu, T Li, AK Tse, WF Fong, SY Pan, A Lu, ZL Yu
Scientific Reports 2015
Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat
J Dempersmier, A Sambeat, O Gulyaeva, SM Paul, CS Hudak, HF Raposo, HY Kwan, C Kang, RH Wong, HS Sul
Molecular Cell 2015
Functions of Prdm16 in thermogenic fat cells
J Ishibashi, P Seale
Temperature 2015
Activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning
MD Neinast, AP Frank, JF Zechner, Q Li, L Vishvanath, BF Palmer, V Aguirre, RK Gupta, DJ Clegg
Molecular Metabolism 2015
Wt1, the mesothelium and the origins and heterogeneity of visceral fat progenitors
YY Chau, N Hastie
Adipocyte 2015
Visceral White Adipose Tissue is Susceptible to Alcohol-Induced Lipodystrophy in Rats: Role of Acetaldehyde
W Zhang, W Zhong, X Sun, Q Sun, X Tan, Q Li, X Sun, Z Zhou
Alcoholism Clinical and Experimental Research 2015
PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1
S Iida, W Chen, T Nakadai, Y Ohkuma, RG Roeder
Genes & development 2015
PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program
MJ Harms, HW Lim, Y Ho, SN Shapira, J Ishibashi, S Rajakumari, DJ Steger, MA Lazar, KJ Won, P Seale
Genes & development 2015
Regulation of systemic energy homeostasis by serotonin in adipose tissues
CM Oh, J Namkung, Y Go, KE Shong, K Kim, H Kim, BY Park, HW Lee, YH Jeon, J Song, M Shong, VK Yadav, G Karsenty, S Kajimura, IK Lee, S Park, H Kim
Nature Communications 2015
De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development
JR Alvarez-Dominguez, Z Bai, D Xu, B Yuan, KA Lo, MJ Yoon, YC Lim, M Knoll, N Slavov, S Chen, P Chen, HF Lodish, L Sun
Cell Metabolism 2015
Brown Adipose Tissue Activation Is Inversely Related to Central Obesity and Metabolic Parameters in Adult Human
Q Wang, M Zhang, M Xu, W Gu, Y Xi, L Qi, B Li, W Wang, Q Sun
PloS one 2015
miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140
F Hu, M Wang, T Xiao, B Yin, L He, W Meng, M Dong, F Liu
Diabetes 2015
Two key temporally distinguishable molecular and cellular components of white adipose tissue browning during cold acclimation: Browning of white adipose tissue during cold acclimation
A Jankovic, I Golic, M Markelic, A Stancic, V Otasevic, B Buzadzic, A Korac, B Korac
The Journal of Physiology 2015
Can Brown Fat Win the Battle Against White Fat?: BAT VERSUS WAT
S Elattar, A Satyanarayana
Journal of Cellular Physiology 2015
Brown and Beige Fat: Molecular Parts of a Thermogenic Machine: Figure 1
P Cohen, BM Spiegelman
Diabetes 2015
The intake of high-fat diets induces the acquisition of brown adipocyte gene expression features in white adipose tissue
E García-Ruiz, B Reynés, R Díaz-Rúa, E Ceresi, P Oliver, A Palou
International Journal of Obesity 2015
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes
A Than, HL He, SH Chua, D Xu, L Sun, MK Leow, P Chen
The Journal of biological chemistry 2015
Brown adipose tissue and bone
ME Lidell, S Enerbäck
International Journal of Obesity Supplements 2015
Fetal endocrine and metabolic adaptations to hypoxia: the role of the hypothalamic-pituitary-adrenal axis: Fig. 1
EA Newby, DA Myers, CA Ducsay
American journal of physiology. Endocrinology and metabolism 2015
Brown and Beige Fat: Physiological Roles beyond Heat Generation
S Kajimura, BM Spiegelman, P Seale
Cell Metabolism 2015
Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice
P Pazos, L Lima, S Tovar, D González-Touceda, C Diéguez, MC García
Scientific Reports 2015
Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity
XR Peng, P Gennemark, G OMahony, S Bartesaghi
Frontiers in Endocrinology 2015
Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity
F Verdeguer, MS Soustek, M Hatting, SM Blättler, D McDonald, JJ Barrow, P Puigserver
Molecular and cellular biology 2015
Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency Promotes Differentiation of Satellite Cells to Brown Adipocytes in a Cholesterol-Dependent Manner
D Nesan, G Tavallaee, D Koh, A Bashiri, R Abdin, DS Ng
The Journal of biological chemistry 2015
Dermal white adipose tissue: a new component of the thermogenic response
CM Alexander, I Kasza, CL Yen, SB Reeder, D Hernando, RL Gallo, CA Jahoda, V Horsley, OA MacDougald
Journal of lipid research 2015
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
M Claussnitzer, SN Dankel, KH Kim, G Quon, W Meuleman, C Haugen, V Glunk, IS Sousa, JL Beaudry, V Puviindran, NA Abdennur, J Liu, PA Svensson, YH Hsu, DJ Drucker, G Mellgren, CC Hui, H Hauner, M Kellis
New England Journal of Medicine 2015
Ghrelin receptor controls obesity by fat burning
Sun Y
Oncotarget 2015
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms
B Lu, Y Diz-Chaves, D Markovic, A Contarino, L Penicaud, F Fanelli, S Clark, H Lehnert, D Cota, DK Grammatopoulos, A Tabarin
International Journal of Obesity 2014
Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans
P Lee, S Smith, J Linderman, AB Courville, RJ Brychta, W Dieckmann, CD Werner, KY Chen, FS Celi
Diabetes 2014
Syndecan-1 is required to maintain intradermal fat and prevent cold stress
I Kasza, Y Suh, D Wollny, RJ Clark, A Roopra, RJ Colman, OA MacDougald, TA Shedd, DW Nelson, MI Yen, CL Yen, CM Alexander
PLoS genetics 2014
Erythropoietin, a Novel Versatile Player Regulating Energy Metabolism beyond the Erythroid System
L Wang, L Di, CT Noguchi
International journal of biological sciences 2014
p53 induces skin aging by depleting Blimp1+ sebaceous gland cells
J Kim, M Nakasaki, D Todorova, B Lake, CY Yuan, C Jamora, Y Xu
Cell Death and Disease 2014
The brain and brown fat
C Contreras, F Gonzalez, J Fernø, C Diéguez, K Rahmouni, R Nogueiras, M López
Annals of Medicine 2014
AMPK is Involved in Mediation of Erythropoietin Influence on Metabolic Activity and Reactive Oxygen Species Production in White Adipocytes
L Wang, L Di, CT Noguchi
The International Journal of Biochemistry & Cell Biology 2014
Prenatal Metformin Exposure in a Maternal High Fat Diet Mouse Model Alters the Transcriptome and Modifies the Metabolic Responses of the Offspring
H Salomäki, M Heinäniemi, LH Vähätalo, L Ailanen, K Eerola, ST Ruohonen, U Pesonen, M Koulu, M Claret
PloS one 2014
Regulation of brown adipocyte metabolism by myostatin/follistatin signaling
R Singh, M Braga, S Pervin
Frontiers in Cell and Developmental Biology 2014
Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
MJ Harms, J Ishibashi, W Wang, HW Lim, S Goyama, T Sato, M Kurokawa, KJ Won, P Seale
Cell Metabolism 2014
Dietary Fucoxanthin Increases Metabolic Rate and Upregulated mRNA Expressions of the PGC-1alpha Network, Mitochondrial Biogenesis and Fusion Genes in White Adipose Tissues of Mice
MT Wu, HN Chou, C Huang
Marine drugs 2014
Prostaglandin E2 signals white-to-brown adipogenic differentiation
V García-Alonso, J Clària
Adipocyte 2014
Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch
P Cohen, JD Levy, Y Zhang, A Frontini, DP Kolodin, KJ Svensson, JC Lo, X Zeng, L Ye, MJ Khandekar, J Wu, SC Gunawardana, AS Banks, JP Camporez, MJ Jurczak, S Kajimura, DW Piston, D Mathis, S Cinti, GI Shulman, P Seale, BM Spiegelman
Cell 2014
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity
P Bi, T Shan, W Liu, F Yue, X Yang, XR Liang, J Wang, J Li, N Carlesso, X Liu, S Kuang
Nature Medicine 2014
Reducing RIP140 Expression in Macrophage Alters ATM Infiltration, Facilitates White Adipose Tissue Browning, and Prevents High-Fat Diet-Induced Insulin Resistance
PS Liu, YW Lin, B Lee, SK McCrady-Spitzer, JA Levine, LN Wei
Diabetes 2014
The Role of SIRT1 in Diabetic Kidney Disease
R Yacoub, K Lee, JC He
Frontiers in Endocrinology 2014
RGC32 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice
XB Cui, JN Luan, J Ye, SY Chen
Journal of Endocrinology 2014
Partial Agonist, Telmisartan, Maintains PPARγ Serine 112 Phosphorylation, and Does Not Affect Osteoblast Differentiation and Bone Mass
V Kolli, LA Stechschulte, AR Dowling, S Rahman, PJ Czernik, B Lecka-Czernik
PloS one 2014
Comprehensive Physiology
SF Morrison, CJ Madden
Comprehensive Physiology 2014
Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers
A Loft, I Forss, MS Siersbæk, SF Schmidt, AS Larsen, JG Madsen, DF Pisani, R Nielsen, MM Aagaard, A Mathison, MJ Neville, R Urrutia, F Karpe, EZ Amri, S Mandrup
Genes & development 2014
Chronic Glucocorticoid Exposure-Induced Epididymal Adiposity Is Associated with Mitochondrial Dysfunction in White Adipose Tissue of Male C57BL/6J Mice
J Yu, B Yu, J He, P Zheng, X Mao, G Han, D Chen, M Alemany
PloS one 2014
Advances in Fetal and Neonatal Physiology
L Zhang, CA Ducsay
2014
Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat
J Suárez, P Rivera, S Arrabal, A Crespillo, A Serrano, E Baixeras, FJ Pavón, M Cifuentes, R Nogueiras, J Ballesteros, C Dieguez, FR de Fonseca
Disease models & mechanisms 2014
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
HB Ruan, MO Dietrich, ZW Liu, MR Zimmer, MD Li, JP Singh, K Zhang, R Yin, J Wu, TL Horvath, X Yang
Cell 2014
Benefits of healthy adipose tissue in the treatment of diabetes
SC Gunawardana
World journal of diabetes 2014
KSRP Ablation Enhances Brown Fat Gene Program in White Adipose Tissue Through Reduced miR-150 Expression
CF Chou, YY Lin, HK Wang, X Zhu, M Giovarelli, P Briata, R Gherzi, WT Garvey, CY Chen
Diabetes 2014
Weighing in on Adipocyte Precursors
R Berry, E Jeffery, MS Rodeheffer
Cell Metabolism 2014
Perivascular Adipose Tissue in Vascular Function and Disease: A Review of Current Research and Animal Models
NK Brown, Z Zhou, J Zhang, R Zeng, J Wu, DT Eitzman, YE Chen, L Chang
Arteriosclerosis, thrombosis, and vascular biology 2014
The different shades of fat
V Peirce, S Carobbio, A Vidal-Puig
Nature 2014
MicroRNA-378 controls classical brown fat expansion to counteract obesity
D Pan, C Mao, B Quattrochi, RH Friedline, LJ Zhu, DY Jung, JK Kim, B Lewis, YX Wang
Nature Communications 2014
Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis
MA Lim, KK Bence, I Sandesara, P Andreux, J Auwerx, J Ishibashi, P Seale, RG Kalb
Human Molecular Genetics 2014
Recent advance in brown adipose physiology and its therapeutic potential
YH Lee, YS Jung, D Choi
Experimental & molecular medicine 2014
β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
LD Roberts, P Boström, JF O’Sullivan, RT Schinzel, GD Lewis, A Dejam, YK Lee, MJ Palma, S Calhoun, A Georgiadi, MH Chen, VS Ramachandran, MG Larson, C Bouchard, T Rankinen, AL Souza, CB Clish, TJ Wang, JL Estall, AA Soukas, CA Cowan, BM Spiegelman, RE Gerszten
Cell Metabolism 2014
A Smooth Muscle-Like Origin for Beige Adipocytes
JZ Long, KJ Svensson, L Tsai, X Zeng, HC Roh, X Kong, RR Rao, J Lou, I Lokurkar, W Baur, JJ Castellot, ED Rosen, BM Spiegelman
Cell Metabolism 2014
Olive Leaf Extract Attenuates Obesity in High-Fat Diet-Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis
Y Shen, SJ Song, N Keum, T Park
Evidence-Based Complementary and Alternative Medicine 2014
Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat
Y Qiu, KD Nguyen, JI Odegaard, X Cui, X Tian, RM Locksley, RD Palmiter, A Chawla
Cell 2014
Methods in Enzymology
R Berry, CD Church, MT Gericke, E Jeffery, L Colman, MS Rodeheffer
Methods in enzymology 2014
Large-scale analysis reveals a functional single-nucleotide polymorphism in the 5′-flanking region of PRDM16 gene associated with lean body mass
T Urano, M Shiraki, N Sasaki, Y Ouchi, S Inoue
Aging Cell 2014
LSD1 promotes oxidative metabolism of white adipose tissue
D Duteil, E Metzger, D Willmann, P Karagianni, N Friedrichs, H Greschik, T Günther, R Buettner, I Talianidis, D Metzger, R Schüle
Nature Communications 2014
Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice
M Rosell, M Kaforou, A Frontini, A Okolo, YW Chan, E Nikolopoulou, S Millership, ME Fenech, D MacIntyre, JO Turner, JD Moore, E Blackburn, WJ Gullick, S Cinti, G Montana, MG Parker, M Christian
American journal of physiology. Endocrinology and metabolism 2014
Molecular heterogeneities of adipose depots - potential effects on adipose-muscle cross-talk in humans, mice and farm animals
K Komolka, E Albrecht, K Wimmers, JJ Michal, S Maak
Journal of genomics 2014
Molecular Aspects of Adipoepithelial Transdifferentiation in Mouse Mammary Gland: Adipoepithelial Transdifferentiation
A Prokesch, A Smorlesi, J Perugini, M Manieri, P Ciarmela, E Mondini, Z Trajanoski, K Kristiansen, A Giordano, JG Bogner-Strauss, S Cinti
Stem Cells 2014
MAGP1, the extracellular matrix, and metabolism
CS Craft
Adipocyte 2014
TAF7L modulates brown adipose tissue formation
H Zhou, B Wan, I Grubisic, T Kaplan, R Tjian, JT Kadonaga
eLife 2014
Inorganic Nitrate Promotes the Browning of White Adipose Tissue Through the Nitrate-Nitrite-Nitric Oxide Pathway
LD Roberts, T Ashmore, AO Kotwica, SA Murfitt, BO Fernandez, M Feelisch, AJ Murray, JL Griffin
Diabetes 2014
Ebf2 is a selective marker of brown and beige adipogenic precursor cells
W Wang, M Kissig, S Rajakumari, L Huang, H Lim, KJ Won, P Seale
Proceedings of the National Academy of Sciences 2014
The Great Roundleaf Bat (Hipposideros armiger) as a Good Model for Cold-Induced Browning of Intra-Abdominal White Adipose Tissue
Y Wang, T Zhu, S Ke, N Fang, DM Irwin, M Lei, J Zhang, H Shi, S Zhang, Z Wang, HB Tanowitz
PloS one 2014
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
JR Brestoff, BS Kim, SA Saenz, RR Stine, LA Monticelli, GF Sonnenberg, JJ Thome, DL Farber, K Lutfy, P Seale, D Artis
Nature 2014
Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development
AC Daquinag, C Tseng, A Salameh, Y Zhang, F Amaya-Manzanares, A Dadbin, F Florez, Y Xu, Q Tong, MG Kolonin
Cell Death and Differentiation 2014
Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue
X Kong, J Yu, J Bi, H Qi, W Di, L Wu, L Wang, J Zha, S Lv, F Zhang, Y Li, F Hu, F Liu, H Zhou, J Liu, G Ding
Diabetes 2014
Irisin ERKs the Fat
J Wu, BM Spiegelman
Diabetes 2014
Gene Delivery to Adipose Tissue Using Transcriptionally Targeted rAAV8 Vectors
S Uhrig-Schmidt, M Geiger, G Luippold, G Birk, D Mennerich, H Neubauer, D Grimm, C Wolfrum, S Kreuz, RJ Samulski
PloS one 2014
SRA Gene Knockout Protects against Diet-induced Obesity and Improves Glucose Tolerance
S Liu, L Sheng, H Miao, TL Saunders, OA MacDougald, RJ Koenig, B Xu
The Journal of biological chemistry 2014
Inducible brown adipocytes in subcutaneous inguinal white fat: the role of continuous sympathetic stimulation
GA Contreras, YH Lee, EP Mottillo, JG Granneman
American journal of physiology. Endocrinology and metabolism 2014
Subcutaneous Adipocytes Promote Melanoma Cell Growth by Activating the Akt Signaling Pathway: ROLE OF PALMITIC ACID
HY Kwan, X Fu, B Liu, X Chao, CL Chan, H Cao, T Su, AK Tse, WF Fong, ZL Yu
The Journal of biological chemistry 2014
MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function
T Fu, S Seok, S Choi, Z Huang, K Suino-Powell, HE Xu, B Kemper, JK Kemper
Molecular and cellular biology 2014
Acupuncture promotes white adipose tissue browning by inducing UCP1 expression on DIO mice
W Shen, Y Wang, SF Lu, H Hong, S Fu, S He, Q Li, J Yue, B Xu, BM Zhu
BMC complementary and alternative medicine 2014
Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic  3-adrenergic receptor activation
EP Mottillo, P Balasubramanian, YH Lee, C Weng, EE Kershaw, JG Granneman
Journal of lipid research 2014
Effects of Vitamin A Status on Expression of Ucp1 and Brown/Beige Adipocyte-Related Genes in White Adipose Tissues of Beef Cattle
KANAMORI Y, YAMADA T, ASANO H, KIDA R, QIAO Y, ABD ELDAIM MA, TOMONAGA S, MATSUI T, FUNABA M
Journal of Veterinary Medical Science 2014
11C-Meta-Hydroxyephedrine Pet/Ct Imaging Allows In Vivo Study Of Adaptive Thermogenesis And White-To-Brown Fat Conversion
C Quarta, F Lodi, R Mazza, FA Giannone, L Boschi, C Nanni, E Nisoli, S Boschi, R Pasquali, S Fanti, P Iozzo, U Pagotto
Molecular Metabolism 2013
Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton
S Rahman, Y Lu, PJ Czernik, CJ Rosen, S Enerback, B Lecka-Czernik
Endocrinology 2013
Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice
YS Lee, T Sasaki, M Kobayashi, O Kikuchi, HJ Kim, H Yokota-Hashimoto, M Shimpuku, VY Susanti, Y Ido-Kitamura, K Kimura, H Inoue, M Tanaka-Okamoto, H Ishizaki, J Miyoshi, S Ohya, Y Tanaka, S Kitajima, T Kitamura
Diabetologia 2013
Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs
CJ Villanueva, L Vergnes, J Wang, BG Drew, C Hong, Y Tu, Y Hu, X Peng, F Xu, E Saez, K Wroblewski, AL Hevener, K Reue, LG Fong, SG Young, P Tontonoz
Cell Metabolism 2013
Inhibition of in vitro and in vivo brown fat differentiation program by myostatin
M Braga, S Pervin, K Norris, S Bhasin, R Singh
Obesity 2013
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance
R Quintens, S Singh, K Lemaire, KD Bock, M Granvik, A Schraenen, IO Vroegrijk, V Costa, PV Noten, D Lambrechts, S Lehnert, LV Lommel, L Thorrez, GD Faudeur, JA Romijn, JM Shelton, L Scorrano, HR Lijnen, PJ Voshol, P Carmeliet, PP Mammen, F Schuit
PloS one 2013
Brown and beige fat: development, function and therapeutic potential
M Harms, P Seale
Nature Medicine 2013
Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues
T Shan, W Liu, S Kuang
The FASEB Journal 2013
Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor   (PPAR ) in the Conversion of White-to-brown Adipocytes
V Garcia-Alonso, C Lopez-Vicario, E Titos, E Moran-Salvador, A Gonzalez-Periz, B Rius, M Parrizas, O Werz, V Arroyo, J Claria
The Journal of biological chemistry 2013
Adipose tissue plasticity from WAT to BAT and in between
YH Lee, EP Mottillo, JG Granneman
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013
Adipose-derived stromal/stem cells
JM Gimble, BA Bunnell, T Frazier, B Rowan, F Shah, C Thomas-Porch, X Wu
Organogenesis 2013
Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes
T Sakamoto, N Takahashi, Y Sawaragi, S Naknukool, R Yu, T Goto, T Kawada
American journal of physiology. Cell physiology 2013
Distinct populations of adipogenic and myogenic Myf5-lineage progenitors in white adipose tissues
T Shan, X Liang, P Bi, P Zhang, W Liu, S Kuang
Journal of lipid research 2013
PPARγ: no SirT, no service
FW Quelle, CD Sigmund
Circulation research 2013
Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice
JS Teodoro, P Zouhar, P Flachs, K Bardova, P Janovska, AP Gomes, FV Duarte, AT Varela, AP Rolo, CM Palmeira, J Kopecký
International Journal of Obesity 2013
Adipose tissue browning and metabolic health
A Bartelt, J Heeren
Nature Reviews Endocrinology 2013
Adaptive thermogenesis in adipocytes: is beige the new brown?
J Wu, P Cohen, BM Spiegelman
Genes & development 2013
A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis
S Kajimura, M Saito
Annual Review of Physiology 2013
PPAR  and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders
L Wang, R Teng, L Di, H Rogers, H Wu, JB Kopp, CT Noguchi
Diabetes 2013
The therapeutic potential of brown adipose tissue
KI Stanford, LJ Goodyear
Hepatobiliary surgery and nutrition 2013
A Role for Phosphodiesterase 3B in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Male Mice
E Guirguis, S Hockman, YW Chung, F Ahmad, O Gavrilova, N Raghavachari, Y Yang, G Niu, X Chen, , S Liu, E Degerman, V Manganiello
Endocrinology 2013
Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle
T Shan, X Liang, P Bi, S Kuang
The FASEB Journal 2013
Adipocytes under assault: Environmental disruption of adipose physiology
SM Regnier, RM Sargis
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013
HDAC9 Knockout Mice Are Protected From Adipose Tissue Dysfunction and Systemic Metabolic Disease During High-Fat Feeding
TK Chatterjee, JE Basford, E Knoll, WS Tong, V Blanco, AL Blomkalns, S Rudich, AB Lentsch, DY Hui, NL Weintraub
Diabetes 2013
Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes
SH Ro, CH Jung, WS Hahn, X Xu, YM Kim, YS Yun, JM Park, KH Kim, M Seo, TY Ha, EA Arriaga, DA Bernlohr, DH Kim
Autophagy 2013
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch
J Wang, R Liu, F Wang, J Hong, X Li, M Chen, Y Ke, X Zhang, Q Ma, R Wang, J Shi, B Cui, W Gu, Y Zhang, Z Zhang, W Wang, X Xia, M Liu, G Ning
Nature Cell Biology 2013
MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse
Y Feuermann, K Kang, O Gavrilova, N Haetscher, SJ Jang, KH Yoo, C Jiang, FJ Gonzalez, GW Robinson, L Hennighausen
RNA biology 2013
Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
M Saito
Diabetes & Metabolism Journal 2013
EBF2 Determines and Maintains Brown Adipocyte Identity
S Rajakumari, J Wu, J Ishibashi, HW Lim, AH Giang, KJ Won, RR Reed, P Seale
Cell Metabolism 2013
Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males
H Yue, J He, Y Ke, H Zhang, C Wang, W Hu, J Gu, W Fu, Y Hu, M Li, Y Liu, Z Zhang
Acta Pharmacologica Sinica 2013
MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16
H Yin, A Pasut, VD Soleimani, CF Bentzinger, G Antoun, S Thorn, P Seale, P Fernando, W van IJcken, F Grosveld, RA Dekemp, R Boushel, ME Harper, MA Rudnicki
Cell Metabolism 2013
MicroRNA networks regulate development of brown adipocytes
M Trajkovski, H Lodish
Trends in Endocrinology & Metabolism 2013
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice
Y Okamatsu-Ogura, K Fukano, A Tsubota, A Uozumi, A Terao, K Kimura, M Saito
PloS one 2013
Novel nuances of human brown fat
C Scheele, TJ Larsen, S Nielsen
Adipocyte 2013
Altered white adipose tissue protein profile in C57BL/6J mice displaying delipidative, inflammatory, and browning characteristics after bitter melon seed oil treatment
CH Hsieh, GC Chen, PH Chen, TF Wu, PM Chao
PloS one 2013
Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes
KA Lo, L Sun
Bioscience Reports 2013
miR-133a regulates adipocyte browning in vivo
W Liu, P Bi, T Shan, X Yang, H Yin, YX Wang, N Liu, MA Rudnicki, S Kuang
PLoS genetics 2013
PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue
S Ringholm, JG Knudsen, L Leick, A Lundgaard, MM Nielsen, H Pilegaard
PloS one 2013
Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice
W Shen, CC Chuang, K Martinez, T Reid, JM Brown, L Xi, L Hixson, R Hopkins, J Starnes, M McIntosh
Journal of lipid research 2013
A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes
W Liu, T Shan, X Yang, S Liang, P Zhang, Y Liu, X Liu, S Kuang
Journal of cell science 2013
The Mechanism of White and Brown Adipocyte Differentiation
H Nakagami
Diabetes & Metabolism Journal 2013
Banting Lecture 2012: Regulation of Adipogenesis: Toward New Therapeutics for Metabolic Disease
BM Spiegelman
Diabetes 2013
Induction of beige-like adipocytes in 3T3-L1 cells.
Asano H, Kanamori Y, Higurashi S, Nara T, Kato K, Matsui T, Funaba M
Journal of Veterinary Medical Science 2013
Cardiac natriuretic peptides induce brown fat thermogenic programs in mouse and human adipocytes through p38MAPK
Marica Bordicchia, Dianxin Liu, Ez-Zoubir Amri, Gerard Ailhaud, Paolo Dessi-Fulgheri, Chaoying Zhang, Nobuyuki Takahashi, Riccardo Sarzani, Sheila Collins
Journal of Clinical Investigation 2012
Chronic overexpression of PNPLA3 variant in mouse liver causes hepatic steatosis
John Zhong Li, Yongcheng Huang, Ruchan Karaman, Pavlina Ivanova, H. Alex Brown, Thomas Roddy, Jose Castro-Perez, Jonathan Cohen, Helen H. Hobbs
Journal of Clinical Investigation 2012
p62 links beta-adrenergic input with mitochondrial function
Timo D. Mueller, Sang Jun Lee, Martin Jastroch, Dhiraj Kabra, Kerstin Stemmer, Michaela Aichler, Bill Abplanalp, Gayathri Ananthakrishnan, Nakul Bhardwaj, Sheila Collins, Senad Divanovic, Max Endele, Brian Finan, Yuanqing Gao, Kirk Habegger, Jazzmin Hembree, Kristy Heppner, Susanna Hofmann, Jenna Holland, Daniela Küchler, Maria Kutschke, Radha Krishna, Maarit Lehti, Rebecca Oelkrug, Nickki Ottaway, Diego Perez-Tilve, Christine Raver, Axel Karl Walch, Sonja Schriever, John Speakman, Yu-Hua Tseng, Maria Diaz-Meco, Paul Pfluger, Jorge Moscat, Matthias Tschoep
Journal of Clinical Investigation 2012
Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
L Federico, H Ren, PA Mueller, T Wu, S Liu, J Popovic, EM Blalock, M Sunkara, H Ovaa, HM Albers, GB Mills, AJ Morris, SS Smyth
Molecular Endocrinology 2012
Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells
M Mori, H Nakagami, G Rodriguez-Araujo, K Nimura, Y Kaneda
PLoS Biology 2012
Getting 'Smad' about obesity and diabetes
CK Tan, HC Chong, EH Tan, NS Tan
Nutrition and Diabetes 2012
A novel therapeutic approach to treating obesity through modulation of TGFβ signaling
A Koncarevic, S Kajimura, M Cornwall-Brady, A Andreucci, A Pullen, D Sako, R Kumar, AV Grinberg, K Liharska, JA Ucran, E Howard, BM Spiegelman, J Seehra, J Lachey
Endocrinology 2012
Adipogenesis
K Sarjeant, JM Stephens
Cold Spring Harbor perspectives in biology 2012
The adipose organ at a glance
S Cinti
Disease models & mechanisms 2012
TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis
L Ye, S Kleiner, J Wu, R Sah, RK Gupta, AS Banks, P Cohen, MJ Khandekar, P Boström, RJ Mepani, D Laznik, TM Kamenecka, X Song, W Liedtke, VK Mootha, P Puigserver, PR Griffin, DE Clapham, BM Spiegelman
Cell 2012
PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
H Ohno, K Shinoda, BM Spiegelman, S Kajimura
Cell Metabolism 2012
Development of insulin resistance in mice lacking PGC-1α in adipose tissues
S Kleiner, RJ Mepani, D Laznik, L Ye, MJ Jurczak, FR Jornayvaz, JL Estall, DC Bhowmick, GI Shulman, BM Spiegelman
Proceedings of the National Academy of Sciences 2012
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
FM Fisher, S Kleiner, N Douris, EC Fox, RJ Mepani, F Verdeguer, J Wu, A Kharitonenkov, JS Flier, E Maratos-Flier, BM Spiegelman
Genes & development 2012
Brown adipose tissue
K Townsend, YH Tseng
Adipocyte 2012
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
L Qiang, L Wang, N Kon, W Zhao, S Lee, Y Zhang, M Rosenbaum, Y Zhao, W Gu, SR Farmer, D Accili
Cell 2012
Novel Aspects of Brown Adipose Tissue Biology
J Heeren, H Münzberg
Endocrinology and metabolism clinics of North America 2012
Overexpression of Endothelial Nitric Oxide Synthase Prevents Diet-Induced Obesity and Regulates Adipocyte Phenotype
BE Sansbury, TD Cummins, Y Tang, J Hellmann, CR Holden, MA Harbeson, Y Chen, RP Patel, M Spite, A Bhatnagar, BG Hill
Circulation research 2012
A new, powerful player in lipoprotein metabolism: brown adipose tissue
A Bartelt, M Merkel, J Heeren
Journal of Molecular Medicine 2012
Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice
RC Tsou, DJ Zimmer, BC Jonghe, KK Bence
Endocrinology 2012
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
JY Huh, G Panagiotou, V Mougios, M Brinkoetter, MT Vamvini, BE Schneider, CS Mantzoros
Metabolism 2012
Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue
A Galmozzi, N Mitro, A Ferrari, E Gers, F Gilardi, C Godio, G Cermenati, A Gualerzi, E Donetti, D Rotili, S Valente, U Guerrini, D Caruso, A Mai, E Saez, ED Fabiani, M Crestani
Diabetes 2012
Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity
IJ Lodhi, L Yin, AP Jensen-Urstad, K Funai, T Coleman, JH Baird, MK El Ramahi, B Razani, H Song, F Fu-Hsu, J Turk, CF Semenkovich
Cell Metabolism 2012
Adipose Tissue, Hormones, and Treatment of Type 1 Diabetes
SC Gunawardana
Current Diabetes Reports 2012
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
PJ Fernandez-Marcos, EH Jeninga, C Canto, T Harach, VC de Boer, P Andreux, N Moullan, E Pirinen, H Yamamoto, SM Houten, K Schoonjans, J Auwerx
Scientific Reports 2012
The Heat is on: A New Avenue to Study Brown Fat Formation in Humans
A Scimè
Frontiers in Endocrinology 2012
Inherent Plasticity of Brown Adipogenesis in White Fat of Mice Allows for Recovery from Effects of Post-Natal Malnutrition
LP Kozak, RA Koza, R Anunciado-Koza, T Mendoza, S Newman
PloS one 2012
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
FW Kiefer, C Vernochet, P O'Brien, S Spoerl, JD Brown, S Nallamshetty, M Zeyda, TM Stulnig, DE Cohen, CR Kahn, J Plutzky
Nature Medicine 2012
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
J Wu, P Boström, LM Sparks, L Ye, JH Choi, AH Giang, M Khandekar, KA Virtanen, P Nuutila, G Schaart, K Huang, H Tu, WD van Marken Lichtenbelt, J Hoeks, S Enerbäck, P Schrauwen, BM Spiegelman
Cell 2012
MyomiR-133 regulates brown fat differentiation through Prdm16
M Trajkovski, K Ahmed, CC Esau, M Stoffel
Nature Cell Biology 2012
PTEN in cancer, metabolism, and aging
A Ortega-Molina, M Serrano
Trends in Endocrinology & Metabolism 2012
Irisin, a Novel Myokine Responsible for Exercise Induced Browning of White Adipose Tissue
RD Mahajan, SK Patra
Indian Journal of Clinical Biochemistry 2012
Association of genes with physiological functions by comparative analysis of pooled expression microarray data
ID Chen, VK Rathi, DS DeAndrade, PY Jay
Physiological genomics 2012
Human BAT possesses molecular signatures that resemble beige/brite cells
LZ Sharp, K Shinoda, H Ohno, DW Scheel, E Tomoda, L Ruiz, H Hu, L Wang, Z Pavlova, V Gilsanz, S Kajimura
PloS one 2012
Androgen effects on adipose tissue architecture and function in nonhuman primates
O Varlamov, AE White, JM Carroll, CL Bethea, A Reddy, O Slayden, RW O'Rourke, CT Roberts
Endocrinology 2012
Therapeutic value of brown adipose tissue
SC Gunawardana
Adipocyte 2012
A PGC1α-dependent myokine that drives browning of white fat and thermogenesis
P Boström, J Wu, MP Jedrychowski, A Korde, L Ye, JC Lo, KA Rasbach, EA Boström, JH Choi, JZ Long, S Kajimura, MC Zingaretti, BF Vind, H Tu, S Cinti, K Højlund, SP Gygi, BM Spiegelman
Nature 2012
An Evi1-C/EBP  Complex Controls Peroxisome Proliferator-Activated Receptor  2 Gene Expression To Initiate White Fat Cell Differentiation
J Ishibashi, Z Firtina, S Rajakumari, KH Wood, HM Conroe, DJ Steger, P Seale
Molecular and cellular biology 2012
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16
E Hondares, M Rosell, J Díaz-Delfín, Y Olmos, M Monsalve, R Iglesias, F Villarroya, M Giralt
The Journal of biological chemistry 2011
Recent progress in the study of brown adipose tissue
X Yao, S Shan, Y Zhang, H Ying
Cell & Bioscience 2011
Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion
T Nagare, H Sakaue, M Matsumoto, Y Cao, K Inagaki, M Sakai, Y Takashima, K Nakamura, T Mori, Y Okada, Y Matsuki, E Watanabe, K Ikeda, R Taguchi, N Kamimura, S Ohta, R Hiramatsu, M Kasuga
The Journal of biological chemistry 2011
Antisense reduction of 11β-hydroxysteroid dehydrogenase type 1 enhances energy expenditure, and insulin sensitivity independent of food intake in C57BL/6J mice on a Western-type diet
G Li, A Hernandez-Ono, RM Crooke, MJ Graham, HN Ginsberg
Metabolism 2011
Adipose tissue stem cells meet preadipocyte commitment: going back to the future
WP Cawthorn, EL Scheller, OA MacDougald
Journal of lipid research 2011
Therapeutic Prospects of Metabolically Active Brown Adipose Tissue in Humans
MJ Betz, S Enerbäck
Frontiers in Endocrinology 2011
Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes
A Krings, S Rahman, S Huang, Y Lu, PJ Czernik, B Lecka-Czernik
Bone 2011
Developmental Origins of the Adipocyte Lineage: New Insights from Genetics and Genomics Studies
N Billon, C Dani
Stem Cell Reviews and Reports 2011
White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis
L Cao, EY Choi, X Liu, A Martin, C Wang, X Xu, MJ During
Cell Metabolism 2011
Forming functional fat: a growing understanding of adipocyte differentiation
AG Cristancho, MA Lazar
Nature Reviews Molecular Cell Biology 2011
Lecithin Cholesterol Acyltransferase Null Mice Are Protected from Diet-induced Obesity and Insulin Resistance in a Gender-specific Manner through Multiple Pathways*
L Li, MA Hossain, S Sadat, L Hager, L Liu, L Tam, S Schroer, L Huogen, IG Fantus, PW Connelly, M Woo, DS Ng
The Journal of biological chemistry 2011
Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation
MR Mirbolooki, CC Constantinescu, ML Pan, J Mukherjee
EJNMMI Research 2011
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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