The white adipose organ is composed of both subcutaneous and several intra-abdominal depots. Excess abdominal adiposity is a major risk factor for metabolic disease in rodents and humans, while expansion of subcutaneous fat does not carry the same risks. Brown adipose produces heat as a defense against hypothermia and obesity, and the appearance of brown-like adipocytes within white adipose tissue depots is associated with improved metabolic phenotypes. Thus, understanding the differences in cell biology and function of these different adipose cell types and depots may be critical to the development of new therapies for metabolic disease. Here, we found that Prdm16, a brown adipose determination factor, is selectively expressed in subcutaneous white adipocytes relative to other white fat depots in mice. Transgenic expression of Prdm16 in fat tissue robustly induced the development of brown-like adipocytes in subcutaneous, but not epididymal, adipose depots. Prdm16 transgenic mice displayed increased energy expenditure, limited weight gain, and improved glucose tolerance in response to a high-fat diet. shRNA-mediated depletion of Prdm16 in isolated subcutaneous adipocytes caused a sharp decrease in the expression of thermogenic genes and a reduction in uncoupled cellular respiration. Finally, Prdm16 haploinsufficiency reduced the brown fat phenotype in white adipose tissue stimulated by β-adrenergic agonists. These results demonstrate that Prdm16 is a cell-autonomous determinant of a brown fat–like gene program and thermogenesis in subcutaneous adipose tissues.
Patrick Seale, Heather M. Conroe, Jennifer Estall, Shingo Kajimura, Andrea Frontini, Jeff Ishibashi, Paul Cohen, Saverio Cinti, Bruce M. Spiegelman
Title and authors | Publication | Year |
---|---|---|
RBM43 controls PGC1α translation and a PGC1α-STING signaling axis
Dumesic PA, Wilensky SE, Bose S, Van Vranken JG, Gygi SP, Spiegelman BM |
Cell metabolism | 2025 |
A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
Osakabe N, Nakamura H, Yoshida Y, Katsuragawa S, Iida N, Fujii Y, Jacob UM, Fritsch T, Abdelhameed A, Calabrese V |
Open Medicine | 2025 |
The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT
Bunk J, Hussain MF, Delgado-Martin M, Samborska B, Ersin M, Shaw A, Rahbani JF, Kazak L |
Nature Communications | 2025 |
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health.
Lecoutre S, Rebière C, Maqdasy S, Lambert M, Dussaud S, Abatan JB, Dugail I, Gautier EL, Clément K, Marcelin G |
Nature reviews. Endocrinology | 2025 |
Modulation of adipose tissue phenotype and longevity-related gene expression by nuclear factor E2-related factor 2 knockdown in 3T3-L1 cells.
Zhang S, Han B, Wang X, Yuan X |
Hormones (Athens, Greece) | 2025 |
Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.
Loft A, Emont MP, Weinstock A, Divoux A, Ghosh A, Wagner A, Hertzel AV, Maniyadath B, Deplancke B, Liu B, Scheele C, Lumeng C, Ding C, Ma C, Wolfrum C, Strieder-Barboza C, Li C, Truong DD, Bernlohr DA, Stener-Victorin E, Kershaw EE, Yeger-Lotem E, Shamsi F, Hui HX, Camara H, Zhong J, Kalucka J, Ludwig JA, Semon JA, Jalkanen J, Whytock KL, Dumont KD, Sparks LM, Muir LA, Fang L, Massier L, Saraiva LR, Beyer MD, Jeschke MG, Mori MA, Boroni M, Walsh MJ, Patti ME, Lynes MD, Blüher M, Rydén M, Hamda N, Solimini NL, Mejhert N, Gao P, Gupta RK, Murphy R, Pirouzpanah S, Corvera S, Tang S, Das SK, Schmidt SF, Zhang T, Nelson TM, O'Sullivan TE, Efthymiou V, Wang W, Tong Y, Tseng YH, Mandrup S, Rosen ED |
Nature metabolism | 2025 |
Perivascular adipose tissue dysfunction contributes to thoracic aortic aneurysm development.
Wang Z, Mu W, Xu R, Zhong J, Xiong W, Zhao X, Liang X, Guo Y, Zhang J, Jiang ZS, Yang B, Chen YE, Chang L |
Cardiovascular diabetology | 2025 |
Bile acid-loaded nanoparticles induce mitochondrial function and decrease adipocyte size in the subcutaneous fat depot
Weinan Zhou, Benjamin Lew, Hyungsoo Choi, Kevin Kim, Sayeepriyadarshini Anakk |
Nano letters | 2024 |
Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance.
Zhang X, Ding X, Wang C, Le Q, Wu D, Song A, Huang G, Luo L, Luo Y, Yang X, Goins AE, Desai SP, Qiu C, Silva FD, Feldman LE, Zhou J, Spafford MF, Boyd NH, Prossnitz ER, Yang XO, Wang QA, Liu M |
Nature metabolism | 2024 |
A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise.
Methi A, Islam MR, Kaurani L, Sakib MS, Krüger DM, Pena T, Burkhardt S, Liebetanz D, Fischer A |
Molecular Neurobiology | 2024 |
Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.
Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR |
Nature metabolism | 2024 |
ACSS2 controls PPARγ activity homeostasis to potentiate adipose-tissue plasticity.
Chen N, Zhao M, Wu N, Guo Y, Cao B, Zhan B, Li Y, Zhou T, Zhu F, Guo C, Shi Y, Wang Q, Li Y, Zhang L |
Cell Death and Differentiation | 2024 |
Dexamethasone Inhibits White Adipose Tissue Browning
Giordano AP, Gambaro SE, Alzamendi A, Harnichar AE, Rey MA, Ongaro L, Spinedi E, Zubiría MG, Giovambattista A |
International journal of molecular sciences | 2024 |
Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue.
Chen H, Sun L, Feng L, Han X, Zhang Y, Zhai W, Zhang Z, Mulholland M, Zhang W, Yin Y |
eLife | 2024 |
Potential Role of Pig UCP3 in Modulating Adipocyte Browning via the Beta-Adrenergic Receptor Signaling Pathway
Kim S, Yazawa T, Koide A, Yoneda E, Aoki R, Okazaki T, Tomita K, Watanabe H, Muroi Y, Testuka M, Muranishi Y |
Biology | 2024 |
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Holman CD, Sakers AP, Calhoun RP, Cheng L, Fein EC, Jacobs C, Tsai L, Rosen ED, Seale P |
eLife | 2024 |
Atomic force microscopy characterization of white and beige adipocyte differentiation.
Mallah A, Stojkova K, Cohen RN, Abu-Lail N, Brey EM, Gonzalez Porras MA |
In vitro cellular & developmental biology. Animal | 2024 |
Insights into the roles of Apolipoprotein E in adipocyte biology and obesity.
Jiang CL, Lin FJ |
International Journal of Obesity | 2024 |
Adipocyte Mitochondria: Deciphering Energetic Functions across Fat Depots in Obesity and Type 2 Diabetes
Das S, Mukhuty A, Mullen GP, Rudolph MC |
International journal of molecular sciences | 2024 |
White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming
Boychenko S, Egorova VS, Brovin A, Egorov AD |
Pharmaceuticals | 2024 |
Carnosic Acid (CA) Induces a Brown Fat-like Phenotype, Increases Mitochondrial Biogenesis, and Activates AMPK in 3T3-L1 Adipocytes
Vlavcheski F, MacPherson RE, Fajardo V, Sze N, Tsiani E |
Biomedicines | 2024 |
Therapeutic potential of adipose-derived stem cell extracellular vesicles: from inflammation regulation to tissue repair
Zhou B, Chen Q, Zhang Q, Tian W, Chen T, Liu Z |
Stem Cell Research & Therapy | 2024 |
Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion
Li Z, Shi B, Li N, Sun J, Zeng X, Huang R, Bok S, Chen X, Han J, Yallowitz AR, Debnath S, Cung M, Ling Z, Zhong CQ, Hong Y, Li G, Koenen M, Cohen P, Su X, Lu H, Greenblatt MB, Xu R |
Nature Communications | 2024 |
Ling-gui-zhu-gan granules reduces obesity and ameliorates metabolic disorders by inducing white adipose tissue browning in obese mice
Li Y, Ye Z, Zhao Y, Xu B, Xue W, Wang Z, An R, Wang F, Wu R |
Frontiers in Physiology | 2024 |
Perivascular Adipose Tissue and Perivascular Adipose Tissue-Derived Extracellular Vesicles: New Insights in Vascular Disease
Sigdel S, Udoh G, Albalawy R, Wang J |
Cells | 2024 |
The pathophysiology of visceral adipose tissues in cardiometabolic diseases
Lee MJ, Kim J |
Biochemical pharmacology | 2024 |
Overexpression of PRDM16 attenuates acute kidney injury progression: genetic and pharmacological approaches.
Li X, Xu F, Zhang P, Mao L, Guo Y, Li H, Xie Y, Li Y, Liao Y, Chen J, Wu D, Zhang D |
MedComm | 2024 |
Directly targeting PRDM16 in thermogenic adipose tissue to treat obesity and its related metabolic diseases
Mao L, Lu J, Hou Y, Nie T |
Frontiers in Endocrinology | 2024 |
CPEB2-activated Prdm16 translation promotes brown adipocyte function and prevents obesity.
Lu WH, Chen HF, King PC, Peng C, Huang YS |
Molecular metabolism | 2024 |
Gene expression and characterization of clonally derived murine embryonic brown and brite adipocytes
Velez\u2010delValle C, Hernandez\u2010Mosqueira CP, Castro\u2010Rodriguez LI, Vazquez\u2010Sandoval A, Marsch\u2010Moreno M, Kuri\u2010Harcuch W |
FEBS Open Bio | 2024 |
Maintenance of thermogenic adipose tissues despite loss of the H3K27 acetyltransferases p300 or CBP
Gamu D, Cameron MS, Gibson WT |
American Journal of Physiology - Endocrinology and Metabolism | 2024 |
The development of hepatic steatosis depends on the presence of liver-innervating parasympathetic cholinergic neurons in mice fed a high-fat diet.
Hwang J, Okada J, Liu L, Pessin JE, Schwartz GJ, Jo YH |
PLoS biology | 2024 |
Ubiquitination and Metabolic Disease.
Ma M, Cao R, Tian Y, Fu X |
Advances in experimental medicine and biology | 2024 |
Interplay between the brain and adipose tissue: a metabolic conversation.
Díaz-Castro F, Morselli E, Claret M |
EMBO reports | 2024 |
Gene Therapy Approach for Treatment of Obese Agouti Mice
Yunin MA, Boychenko SS, Lebedev P, Deykin AV, Pokrovskii MV, Egorov AD |
International Journal of Molecular Sciences | 2024 |
Effects of time-restricted feeding (TRF)-model of intermittent fasting on adipose organ: a narrative review
Bahadoran Z, Mirmiran P, Kashfi K, Ghasemi A |
Eating and Weight Disorders | 2024 |
Branched‐chain amino acid metabolism: Pathophysiological mechanism and therapeutic intervention in metabolic diseases
Mansoori S, Ho MY, Ng KK, Cheng KK |
Obesity Reviews | 2024 |
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice
Yu X, Chen S, Funcke JB, Straub LG, Pirro V, Emont MP, Droz BA, Collins KA, Joung C, Pearson MJ, James CM, Babu GJ, Efthymiou V, Vernon A, Patti ME, An YA, Rosen ED, Coghlan MP, Samms RJ, Scherer PE, Kusminski CM |
Cell metabolism | 2024 |
Development of a Functional Beige Fat Cell Line Uncovers Independent Subclasses of Cells Expressing UCP1 and the Futile Creatine Cycle
Vargas-Castillo A, Sun Y, Smythers AL, Grauvogel L, Dumesic PA, Emont MP, Tsai LT, Rosen ED, Zammit NW, Shaffer S, Ordonez M, Chouchani ET, Gygi SP, Wang T, Sharma A, Balaz M, Wolfrum C, Spiegelman BM |
Cell metabolism | 2024 |
PRDM16 in thermogenic adipocytes mediates an inter-organ protective signaling against alcohol-associated liver disease
Liu S, Zhu K, Huang Y, Ye W, Wu J |
Molecular and cellular endocrinology | 2024 |
Overexpression of PRDM16 improves muscle function after rotator cuff tears
Zhang H, Wague A, Diaz A, Liu M, Sang L, Youn A, Sharma S, Milan N, Kim H, Feeley B, Liu X |
Journal of shoulder and elbow surgery | 2024 |
mTORC1 inhibition-induced uncoupling between lipolysis and thermogenesis in white adipose tissue contributes alcoholic liver disease
Qing Song, Yingli Chen, Qinchao Ding, Alexandra Griffiths, Lifeng Liu, Jooman Park, Natalia Nieto, Songtao Li, Xiaobing Dou, Yuwei Jiang, Zhenyuan Song |
Hepatology Communications | 2023 |
NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis
Yuta Hiraike, Kaede Saito, Misato Oguchi, Shuichi Tsutsumi, Takahito Wada, Gotaro Toda, Kana Bando, Naoto Kubota, Tetsuya Kubota, Hiroyuki Aburatani, Takashi Kadowaki, Hironori Waki, Toshimasa Yamauchi |
Proceedings of the National Academy of Sciences | 2023 |
PRDM16 Deficiency in Vascular Smooth Muscle Cells Aggravates Abdominal Aortic Aneurysm
Zhenguo Wang, Xiangjie Zhao, Guizhen Zhao, Yanhong Guo, Haocheng Lu, Wenjuan Mu, Juan Zhong, Minerva Garcia-Barrio, Jifeng Zhang, Y. Eugene Chen, Lin Chang |
JCI Insight | 2023 |
Deletion of Spinophilin Promotes White Adipocyte Browning
Gou W, Wei H, Swaby L, Green E, Wang H |
Pharmaceuticals | 2023 |
Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy
Chen W, Xu Z, You W, Zhou Y, Wang L, Huang Y, Shan T |
BMC Biology | 2023 |
Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes.
Lee HS, Heo CU, Song YH, Lee K, Choi CI |
Archives of Pharmacal Research | 2023 |
Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice
Cheong LY, Wang B, Wang Q, Jin L, Kwok KH, Wu X, Shu L, Lin H, Chung SK, Cheng KK, Hoo RL, Xu A |
Nature Communications | 2023 |
The Association of Serum Irisin with Impaired Glucose Before and After Laparoscopic Sleeve Gastrectomy in Obesity.
Yin J, Yang S, Zha X, Miao Z, Sheng C, Yang P, Wang X, Qu S |
Obesity surgery | 2023 |
Four anti-aging drugs and calorie-restricted diet produce parallel effects in fat, brain, muscle, macrophages, and plasma of young mice.
Li X, McPherson M, Hager M, Lee M, Chang P, Miller RA |
GeroScience | 2023 |
Deficiency of lipopolysaccharide binding protein facilitates adipose browning, glucose uptake and oxygen consumption in mouse embryonic fibroblasts via activating PI3K/Akt/mTOR pathway and inhibiting autophagy.
Yin X, Xu Z, Zhang X, Wu J, Lu W |
Cell cycle (Georgetown, Tex.) | 2023 |
Anti-Inflammatory, Antioxidant, and WAT/BAT-Conversion Stimulation Induced by Novel PPAR Ligands: Results from Ex Vivo and In Vitro Studies
Recinella L, De Filippis B, Libero ML, Ammazzalorso A, Chiavaroli A, Orlando G, Ferrante C, Giampietro L, Veschi S, Cama A, Mannino F, Gasparo I, Bitto A, Amoroso R, Brunetti L, Leone S |
Pharmaceuticals | 2023 |
A PPARγ-long noncoding RNA axis regulates adipose thermoneutral remodeling
Zhengyi Zhang, Ya Cui, Vivien N. Su, Marcus Tol, Lijing Cheng, Xiaohui Wu, Jason Kim, Prashant Rajbhandari, Sicheng Zhang, Wei Li, Peter Tontonoz, Claudio Villanueva, Tamer Sallam |
Journal of Clinical Investigation | 2023 |
Discovery of PRDM16-mediated TRPA1 induction as the mechanism for low tubulo-interstitial fibrosis in diabetic kidney disease
Fang Xu, Hongwei Jiang, Xiaozhou Li, Jian Pan, huiling li, Luxiang Wang, Pan Zhang, Junxiang Chen, Shuangfa Qiu, Yuxin Xie, Yijian Li, Dongshan Zhang, Zheng Dong |
Advanced Science | 2023 |
Tankyrase: a promising therapeutic target with pleiotropic action.
Sagathia V, Patel C, Beladiya J, Patel S, Sheth D, Shah G |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2023 |
Mitochondria-associated regulation in adipose tissues and potential reagents for obesity intervention
Zheng Y, Yang N, Pang Y, Gong Y, Yang H, Ding W, Yang H |
Frontiers in Endocrinology | 2023 |
Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management
Shaik Mohamed Sayed UF, Moshawih S, Goh HP, Kifli N, Gupta G, Singh SK, Chellappan DK, Dua K, Hermansyah A, Ser HL, Ming LC, Goh BH |
Frontiers in pharmacology | 2023 |
Dose- and Time-Dependent Effects of Radiofrequency Electromagnetic Field on Adipose Tissue: Implications of Thermoregulation and Mitochondrial Signaling
Maalouf J, Pelletier A, Corona A, Gay-Quéheillard J, Bach V, de Seze R, Selmaoui B |
International journal of molecular sciences | 2023 |
Molecular and cellular regulation of thermogenic fat
Wang C, Wang X, Hu W |
Frontiers in Endocrinology | 2023 |
Physiological Approaches Targeting Cellular and Mitochondrial Pathways Underlying Adipose Organ Senescence
de Lange P, Lombardi A, Silvestri E, Cioffi F, Giacco A, Iervolino S, Petito G, Senese R, Lanni A, Moreno M |
International journal of molecular sciences | 2023 |
Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte
Zhao S, Nie T, Li L, Long Q, Gu P, Zhang Y, Sun W, Lin Z, Liu Q, Qi Y, Wang W, Xie M, Loomes K, Cai C, Wu D, Hui HX |
Advanced Science | 2023 |
Identification of the enhancer RNAs related to tumorgenesis of pituitary neuroendocrine tumors
Wang L, Wei C, Wang Y, Huang N, Zhang T, Dai Y, Xue L, Lin S, Wu ZB |
Frontiers in Endocrinology | 2023 |
Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix.
Nigro P, Vamvini M, Yang J, Caputo T, Ho LL, Carbone NP, Papadopoulos D, Conlin R, He J, Hirshman MF, White JD, Robidoux J, Hickner RC, Nielsen S, Pedersen BK, Kellis M, Middelbeek RJW, Goodyear LJ |
Cell Reports | 2023 |
Circadian mechanisms in adipose tissue bioenergetics and plasticity.
Hepler C, Bass J |
Genes & development | 2023 |
Nipsnap1—A regulatory factor required for long-term maintenance of non-shivering thermogenesis
Liu Y, Qu Y, Cheng C, Tsai PY, Edwards K, Xue S, Pandit S, Eguchi S, Sanghera N, Barrow JJ |
Molecular Metabolism | 2023 |
Inhibition of PPARγ by BZ26, a GW9662 derivate, attenuated obesity-related breast cancer progression by inhibiting the reprogramming of mature adipocytes into to cancer associate adipocyte-like cells
Li L, Geng J, Yu W, Zhou F, Zheng Z, Fu K, Kong J, Feng X |
Frontiers in pharmacology | 2023 |
CDK6 is essential for mesenchymal stem cell proliferation and adipocyte differentiation
Hu AJ, Li W, Pathak A, Hu GF, Hou X, Farmer SR, Hu MG |
Frontiers in Molecular Biosciences | 2023 |
Latest advances in the regulatory genes of adipocyte thermogenesis
Nie T, Lu J, Zhang H, Mao L |
Frontiers in Endocrinology | 2023 |
Promoting metabolic inefficiency for metabolic disease
Kazak L |
iScience | 2023 |
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.
Holman CD, Sakers AP, Calhoun RP, Cheng L, Fein EC, Jacobs C, Tsai L, Rosen ED, Seale P |
bioRxiv : the preprint server for biology | 2023 |
Transcriptomics profiling reveal the heterogeneity of white and brown adipocyte.
Zhang Z, Xu L, Zhang L, Lu J, Peng Z, Guo X, Gao J |
Journal of Bioenergetics and Biomembranes | 2023 |
Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis
Huang X, Li X, Shen H, Zhao Y, Zhou Z, Wang Y, Yao J, Xue K, Wu D, Qiu Y |
Nature Communications | 2023 |
Selegiline Modulates Lipid Metabolism by Activating AMPK Pathways of Epididymal White Adipose Tissues in HFD-Fed Obese Mice
Joung HY, Oh JM, Song MS, Kwon YB, Chun S |
Pharmaceutics | 2023 |
Lactate Conversion by Lactate Dehydrogenase B Is Involved in Beige Adipocyte Differentiation and Thermogenesis in Mice
Guo B, Shu H, Luo L, Liu X, Ma Y, Zhang J, Liu Z, Zhang Y, Fu L, Song T, Qiao Y, Zhang C |
Nutrients | 2023 |
Increasing adipocyte number and reducing adipocyte size: the role of retinoids in adipose tissue development and metabolism.
Wang B, Du M |
Critical Reviews in Food Science and Nutrition | 2023 |
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators
Kühnisch J, Theisen S, Dartsch J, Fritsche-Guenther R, Kirchner M, Obermayer B, Bauer A, Kahlert AK, Rothe M, Beule D, Heuser A, Mertins P, Kirwan JA, Berndt N, MacRae CA, Hubner N, Klaassen S |
Cardiovascular Research | 2023 |
Somatosensory Innervation of Adipose Tissues
Wang Y, Ye L |
Physiology & behavior | 2023 |
Effects of exercise intensity on white adipose tissue browning and its regulatory signals in mice
R Tanimura, L Kobayashi, T Shirai, T Takemasa |
Physiological Reports | 2022 |
Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue
Y Yoshida, I Shimizu, Y Hsiao, M Suda, G Katsuumi, M Seki, Y Suzuki, S Okuda, T Soga, T Minamino |
iScience | 2022 |
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16
Q Ma, W Zhu, X Lu, D Jiang, F Xu, J Li, L Zhang, Y Wu, Z Chen, M Yin, H Huang, Q Lei |
Nature metabolism | 2022 |
WT1 in Adipose Tissue: From Development to Adult Physiology
K Kirschner, H Scholz |
Frontiers in Cell and Developmental Biology | 2022 |
PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes
N Jiang, M Yang, Y Han, H Zhao, L Sun |
Frontiers in pharmacology | 2022 |
Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity
M Nazari, K Ho, N Langley, K Cha, R Kodsi, M Wang, D Laybutt, K Cheng, R Stokes, M Swarbrick, J Gunton |
Scientific Reports | 2022 |
Deconstructing Adipose Tissue Heterogeneity One Cell at a Time
D Duerre, A Galmozzi |
Frontiers in Endocrinology | 2022 |
Differential Expression of Metabolism-Related Genes in Plateau Pika (Ochotona curzoniae) at Different Altitudes on the Qinghai–Tibet Plateau
Zhu H, Zhong L, Li J, Wang S, Qu J |
Frontiers in Genetics | 2022 |
Reduced chromatin accessibility correlates with resistance to Notch activation
van den Ameele J, Krautz R, Cheetham SW, Donovan AP, Llorà-Batlle O, Yakob R, Brand AH |
Nature Communications | 2022 |
The Adipose Tissue Macrophages Central to Adaptive Thermoregulation
Rahman MS, Jun H |
Frontiers in immunology | 2022 |
An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation
Díaz de León-Guerrero S, Salazar-León J, Meza-Sosa KF, Valle-Garcia D, Aguilar-León D, Pedraza-Alva G, Pérez-Martínez L |
Disease models & mechanisms | 2022 |
Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis
Wei L, Shi J |
Frontiers in Endocrinology | 2022 |
Deletion of GPR30 Drives the Activation of Mitochondrial Uncoupling Respiration to Induce Adipose Thermogenesis in Female Mice.
Luo J, Wang Y, Gilbert E, Liu D |
Frontiers in Endocrinology | 2022 |
Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues.
Pan R, Chen Y |
Frontiers in Endocrinology | 2022 |
DEPP Deficiency Contributes to Browning of White Adipose Tissue
Guo F, Zhu Y, Han Y, Feng X, Pan Z, He Y, Li Y, Jin L |
International journal of molecular sciences | 2022 |
FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics
Yin Y, Xu D, Mao Y, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z |
Journal of Experimental Medicine | 2022 |
DNA methylation profiles in the blood of newborn term infants born to mothers with obesity
Sasaki A, Murphy KE, Briollais L, McGowan PO, Matthews SG |
PloS one | 2022 |
Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA Gm15551
Engelhard CA, Huang C, Khani S, Kasparek P, Prochazka J, Rozman J, Reguera DP, Sedlacek R, Kornfeld JW |
Non-Coding RNA | 2022 |
Calcium burns beige
Bunk J, Kazak L |
Journal of Experimental Medicine | 2022 |
The Emerging Use of ASC/Scaffold Composites for the Regeneration of Osteochondral Defects
Rahman G, Frazier TP, Gimble JM, Mohiuddin OA |
Frontiers in Bioengineering and Biotechnology | 2022 |
Regulation of Adipose Tissue Biology by Long-Chain Fatty Acids: Metabolic Effects and Molecular Mechanisms
Shin S |
Journal of Obesity & Metabolic Syndrome | 2022 |
The Role of Thermogenic Fat Tissue in Energy Consumption
Horino M, Ikeda K, Yamada T |
Current issues in molecular biology | 2022 |
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
Wang Q, Li H, Tajima K, Verkerke ARP, Taxin ZH, Hou Z, Cole JB, Li F, Wong J, Abe I, Pradhan RN, Yamamuro T, Yoneshiro T, Hirschhorn JN, Kajimura S |
Nature | 2022 |
The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer.
Bunnell BA, Martin EC, Matossian MD, Brock CK, Nguyen K, Collins-Burow B, Burow ME |
Cancer metastasis reviews | 2022 |
LncRNA and mRNA expression profiles in brown adipose tissue of obesity-prone and obesity-resistant mice
Wang C, Duan M, Lin J, Wang G, Gao H, Yan M, Chen L, He J, Liu W, Yang F, Zhu S |
iScience | 2022 |
TFAM expression in brown adipocytes confers obesity resistance by secreting extracellular vesicles that promote self-activation
Fujii M, Setoyama D, Gotoh K, Dozono Y, Yagi M, Ikeda M, Ide T, Uchiumi T, Kang D |
iScience | 2022 |
Remodeling of Adipose Tissues by Fatty Acids: Mechanistic Update on Browning and Thermogenesis by n-3 Polyunsaturated Fatty Acids.
Raj RR, Lofquist S, Lee MJ |
Pharmaceutical Research | 2022 |
Novel Plant Extract Ameliorates Metabolic Disorder through Activation of Brown Adipose Tissue in High-Fat Diet-Induced Obese Mice
Kim JW, Yang YM, Kwon EY, Choi JY |
International journal of molecular sciences | 2022 |
The role of somatosensory innervation of adipose tissues.
Wang Y, Leung VH, Zhang Y, Nudell VS, Loud M, Servin-Vences MR, Yang D, Wang K, Moya-Garzon MD, Li VL, Long JZ, Patapoutian A, Ye L |
Nature | 2022 |
Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases
Machado SA, Pasquarelli-do-Nascimento G, da Silva DS, Farias GR, de Oliveira Santos I, Baptista LB, Magalhães KG |
Nutrition & Metabolism | 2022 |
Relationships between the expression of adipose genes and profiles of hospitalized dogs.
Sugiyama Y, Shimokawa F, Sugiyama K, Kobayashi T, Yamashita Y, Kazama K, Onda K, Funaba M, Murakami M |
Veterinary Research Communications | 2022 |
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease.
Uddin MDM, Nguyen NQH, Yu B, Brody JA, Pampana A, Nakao T, Fornage M, Bressler J, Sotoodehnia N, Weinstock JS, Honigberg MC, Nachun D, Bhattacharya R, Griffin GK, Chander V, Gibbs RA, Rotter JI, Liu C, Baccarelli AA, Chasman DI, Whitsel EA, Kiel DP, Murabito JM, Boerwinkle E, Ebert BL, Jaiswal S, Floyd JS, Bick AG, Ballantyne CM, Psaty BM, Natarajan P, Conneely KN |
Nature Communications | 2022 |
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases.
Yin X, Chen Y, Ruze R, Xu R, Song J, Wang C, Xu Q |
Signal Transduction and Targeted Therapy | 2022 |
The Adipose Organ Is a Unitary Structure in Mice and Humans
Giordano A, Cinti F, Canese R, Carpinelli G, Colleluori G, Di Vincenzo A, Palombelli G, Severi I, Moretti M, Redaelli C, Partridge J, Zingaretti MC, Agostini A, Sternardi F, Giovagnoni A, Castorina S, Cinti S |
Biomedicines | 2022 |
Olanzapine induces weight gain in offspring of prenatally exposed poly I:C rats by reducing brown fat thermogenic activity
Chen X, Liu L, Zeng Y, Li D, Liu X, Hu C |
Frontiers in pharmacology | 2022 |
Improved Adipose Tissue Function after Single Anastomosis Duodeno-Ileal Bypass with Sleeve-Gastrectomy (SADI-S) in Diet-Induced Obesity
Becerril S, Tuero C, Cienfuegos JA, Rodríguez A, Catalán V, Ramírez B, Valentí V, Moncada R, Unamuno X, Gómez-Ambrosi J, Frühbeck G |
International journal of molecular sciences | 2022 |
Selection-driven adaptation to the extreme Antarctic environment in the Emperor penguin.
Pirri F, Ometto L, Fuselli S, Fernandes FAN, Ancona L, Perta N, Di Marino D, Le Bohec C, Zane L, Trucchi E |
Heredity | 2022 |
Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity
Mathur N, Severinsen MC, Jensen ME, Naver L, Schrölkamp M, Laye MJ, Watt MJ, Nielsen S, Krogh-Madsen R, Pedersen BK, Scheele C |
Frontiers in Cell and Developmental Biology | 2022 |
In vitro transdifferentiated signatures of goat preadipocytes into mammary epithelial cells revealed by DNA methylation and transcriptome profiling
Yan XR, Shi T, Xiao JY, Liu YF, Zheng HL |
The Journal of biological chemistry | 2022 |
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex
Shen H, He T, Wang S, Hou L, Wei Y, Liu Y, Mo C, Zhao Z, You W, Guo H, Li B |
Theranostics | 2022 |
Neonatal intake of Omega-3 fatty acids enhances lipid oxidation in adipocyte precursors
Varshney R, Das S, Trahan GD, Farriester JW, Mullen GP, Kyere-Davies G, Presby DM, Houck JA, Webb PG, Dzieciatkowska M, Jones KL, Rodeheffer MS, Friedman JE, MacLean PS, Rudolph MC |
iScience | 2022 |
Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism
Chae SA, Son JS, de Avila JM, Du M, Zhu MJ |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2022 |
LSD1 for the Targeted Regulation of Adipose Tissue
Chen L, Sun X, Chen D, Gui Q |
Current issues in molecular biology | 2022 |
Brown Adipose Tissue—A Translational Perspective
Carpentier AC, Blondin DP, Haman F, Richard D |
Endocrine reviews | 2022 |
The sympathetic nervous system in the 21st Century: neuro-immune interactions in metabolic homeostasis and obesity
Martinez-Sanchez N, Sweeney O, Sidarta-Oliveira D, Caron A, Stanley SA, Domingos AI |
Neuron | 2022 |
Time Restricted Feeding Mitigates Obesity Through Adipocyte Thermogenesis
Hepler C, Weidemann BJ, Waldeck NJ, Marcheva B, Cedernaes J, Thorne AK, Kobayashi Y, Nozawa R, Newman MV, Gao P, Shao M, Ramsey KM, Gupta RK, Bass J |
Science (New York, N.Y.) | 2022 |
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis
Shuai Yan, Manju Kumari, Haopeng Xiao, Christopher Jacobs, Shihab Kochumon, Mark Jedrychowski, Edward Chouchani, Rasheed Ahmad, Evan D. Rosen |
Journal of Clinical Investigation | 2021 |
Pioglitazone does not synergize with mirabegron to increase beige fat or further improve glucose metabolism
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E Dupont-Versteegden, Philip A. Kern |
JCI Insight | 2021 |
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation
R Wu, Y Chen, Y Liu, L Zhuang, W Chen, B Zeng, X Liao, G Guo, Y Wang, X Wang |
EMBO reports | 2021 |
Single-cell chromatin accessibility and lipid profiling reveals SCD1-dependent metabolic shift in adipocytes induced by bariatric surgery
B Harlan, HG Park, R Spektor, B Cummings, JT Brenna, PD Soloway, K Sun |
PloS one | 2021 |
Beige fat is dispensable for the metabolic benefits associated with myostatin deletion
F Marchildon, J Chi, S O'Connor, H Bediako, P Cohen |
Molecular Metabolism | 2021 |
Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity
Z Wang, X Gao, Q Li, H Zhu, X Zhao, M Garcia-Barrio, J Zhang, Y Guo, YE Chen, R Zeng, JR Wu, L Chang |
Frontiers in physiology | 2021 |
PRDM16 Inhibits Cell Proliferation and Migration via Epithelial-to-Mesenchymal Transition by Directly Targeting Pyruvate Carboxylase in Papillary Thyroid Cancer
WL Liu, Q Guan, D Wen, B Ma, WB Xu, JQ Hu, WJ Wei, DS Li, Y Wang, J Xiang, T Liao, QH Ji |
Frontiers in Cell and Developmental Biology | 2021 |
G q α/G 11 α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity
EA Wilson, H Sun, Z Cui, MT Jahnke, M Pandey, P Metzger, O Gavrilova, M Chen, LS Weinstein |
American journal of physiology. Endocrinology and metabolism | 2021 |
Contributions of microRNAs to Peripheral Insulin Sensitivity
K Kim, S Hartig |
Endocrinology | 2021 |
Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
BB Brandão, A Poojari, A Rabiee |
International journal of molecular sciences | 2021 |
The cellular and functional complexity of thermogenic fat
P Cohen, S Kajimura |
Nature Reviews Molecular Cell Biology | 2021 |
D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism
HJ Jeon, DK Choi, JH Choi, S Lee, H Lee, JH Yu, SH Min |
Cells | 2021 |
Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes
JD Painter, O Akbari |
Frontiers in immunology | 2021 |
Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis
L Crudele, E Piccinin, A Moschetta |
Nutrients | 2021 |
Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue
Y Choi, L Yu |
Pharmaceutical Research | 2021 |
Overview of the molecular mechanisms contributing to the formation of cancer‑associated adipocytes (Review)
Y Tang, W Zhang, T Sheng, , X Xiong |
Molecular medicine reports | 2021 |
Overexpression of Adiponectin Receptor 1 Inhibits Brown and Beige Adipose Tissue Activity in Mice
YJ Chen, CW Lin, YJ Peng, CW Huang, YS Chien, TH Huang, PX Liao, WY Yang, MH Wang, HJ Mersmann, SC Wu, TY Chuang, YY Lin, WH Kuo, ST Ding |
International journal of molecular sciences | 2021 |
SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes
F Molinari, A Feraco, S Mirabilii, S Saladini, L Sansone, E Vernucci, G Tomaselli, V Marzolla, D Rotili, MA Russo, MR Ricciardi, A Tafuri, A Mai, M Caprio, M Tafani, A Armani |
Cells | 2021 |
The Role of Mondo Family Transcription Factors in Nutrient-Sensing and Obesity
H Ke, Y Luan, S Wu, Y Zhu, X Tong |
Frontiers in Endocrinology | 2021 |
Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders
S Pervin, ST Reddy, R Singh |
Frontiers in Endocrinology | 2021 |
miR-21 mimic blocks obesity in mice: A novel therapeutic option
S Lhamyani, AM Gentile, RM Giráldez-Pérez, M Feijóo-Cuaresma, SY Romero-Zerbo, M Clemente-Postigo, H Zayed, W Oliva-Olivera, FJ Bermúdez-Silva, J Salas, CL Gómez, A Hmadcha, N Hajji, G Olveira, FJ Tinahones, RE Bekay |
Molecular Therapy — Nucleic Acids | 2021 |
LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis
A BastHabersbrunner, C Kiefer, P Weber, T Fromme, A Schießl, PC Schwalie, B Deplancke, Y Li, M Klingenspor |
EMBO reports | 2021 |
Browning of White Adipose Tissue as a Therapeutic Tool in the Fight against Atherosclerosis
CL Roth, F Molica, BR Kwak |
Metabolites | 2021 |
Recruitment of Thermogenic Fat: Trigger of Fat Burning
Z Wang, X Yu, Y Chen |
Frontiers in Endocrinology | 2021 |
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
A Whitehead, FN Krause, A Moran, AD MacCannell, JL Scragg, BD McNally, E Boateng, SA Murfitt, S Virtue, J Wright, J Garnham, GR Davies, J Dodgson, JE Schneider, AJ Murray, C Church, A Vidal-Puig, KK Witte, JL Griffin, LD Roberts |
Nature Communications | 2021 |
Circadian Rhythms of the Hypothalamus: From Function to Physiology
RV Drunen, K Eckel-Mahan |
2021 | |
Nutmeg extract potentially alters characteristics of white adipose tissue in rats
R Lesmana, M Siannoto, GI Nugraha, H Goenawan, AK Feinisa, YS Pratiwi, F Veronica, VM Tarawan, S Susianti, U Supratman |
Veterinary Medicine and Science | 2021 |
Brown adipose tissue is associated with cardiometabolic health
T Becher, S Palanisamy, DJ Kramer, M Eljalby, SJ Marx, AG Wibmer, SD Butler, CS Jiang, R Vaughan, H Schöder, A Mark, P Cohen |
Nature Medicine | 2021 |
Resident and migratory adipose immune cells control systemic metabolism and thermogenesis
K Man, A Kallies, A Vasanthakumar |
Cellular and Molecular Immunology | 2021 |
Mouse model of the adipose organ: the heterogeneous anatomical characteristics
KH Chun |
Archives of Pharmacal Research | 2021 |
Uncoupling protein-1 expression does not protect mice from diet-induced obesity
H Wang, M Willershäuser, Y Li, T Fromme, K Schnabl, A Bast-Habersbrunner, S Ramisch, S Mocek, M Klingenspor |
American journal of physiology. Endocrinology and metabolism | 2021 |
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice
S Wang, Q Cao, X Cui, J Jing, F Li, H Shi, B Xue, H Shi |
Biomolecules | 2021 |
Brown Fat Dnmt3b Deficiency Ameliorates Obesity in Female Mice
F Li, X Cui, J Jing, S Wang, H Shi, B Xue, H Shi |
Life Sciences | 2021 |
Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease
E Parra-Peralbo, A Talamillo, R Barrio |
Frontiers in Cell and Developmental Biology | 2021 |
Epigenetic Regulators of White Adipocyte Browning
R Nanduri |
Epigenomes | 2021 |
FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis
H Li, X Zhang, C Huang, H Liu, Q Zhang, Q Sun, Y Jia, S Liu, M Dong, M Hou, Y Liu, H Lin |
Molecular Metabolism | 2021 |
Dichotomy in the Impact of Elevated Maternal Glucose Levels on Neonatal Epigenome
I Lim, X Lin, A Teh, Y Wu, L Chen, M He, S Chan, J MacIsaac, J Chan, K Tan, M Chong, M Kobor, K Godfrey, M Meaney, Y Lee, J Eriksson, P Gluckman, Y Chong, N Karnani |
The Journal of clinical endocrinology and metabolism | 2021 |
Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure
A Qiao, W Ma, J Deng, J Zhou, C Han, E Zhang, C Boriboun, S Xu, C Zhang, C Jie, J Kim, KM Habegger, H Qiu, TC Zhao, J Zhang, G Qin |
The FASEB Journal | 2021 |
CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells
Chakraborty S, Ong WK, Yau WW, Zhou Z, Bhanu Prakash KN, Toh SA, Han W, Yen PM, Sugii S |
Stem Cell Research & Therapy | 2021 |
Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat
Chi J, Lin Z, Barr W, Crane A, Zhu XG, Cohen P |
eLife | 2021 |
Characterization of structural variation in Tibetans reveals new evidence of high-altitude adaptation and introgression
Quan C, Li Y, Liu X, Wang Y, Ping J, Lu Y, Zhou G |
Genome biology | 2021 |
Prdm16-Mediated Browning is Involved in Resistance to Diet-Induced and Monosodium Glutamate-Induced Obesity
Liang J, Jia Y, Yan H, Shen Q, Bian W, Zhao D, Xu Y, Jin Y, Yang M |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | 2021 |
ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes
Shao M, Zhang Q, Truong A, Shan B, Vishvanath L, Li L, Seale P, Gupta RK |
Genes & development | 2021 |
Is endothelial dysfunction a therapeutic target for Peripheral Artery Disease?
Kumar S, Andueza A, Jo H |
Circulation research | 2021 |
Expression of Circulating MicroRNAs and Myokines and Interactions with Serum Osteopontin in Type 2 Diabetic Patients with Moderate and Poor Glycemic Control: A Biochemical and Molecular Study
Al-Rawaf HA, Alghadir AH, Gabr SA |
BioMed Research International | 2021 |
Adipose Tissue-Derived Mesenchymal Stem Cells
Bunnell BA |
Cells | 2021 |
Flavonoid‐enriched extract from Millettia speciosa Champ prevents obesity by regulating thermogenesis and lipid metabolism in high‐fat diet–induced obese C57BL/6 mice
Wang M, Ma W, Wang Q, Yang Q, Yan X, Tang H, Li Z, Li Y, Feng S, Wang Z |
Food Science & Nutrition | 2021 |
Protective Effects of Individual and Combined Low Dose Beta-Carotene and Metformin Treatments against High-Fat Diet-Induced Responses in Mice.
Stojnić B, Serrano A, Sušak L, Palou A, Bonet ML, Ribot J |
Nutrients | 2021 |
Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin
Wargent ET, Ahmad SJ, Lu QR, Kostenis E, Arch JR, Stocker CJ |
Frontiers in Endocrinology | 2021 |
Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet
Kirschner KM, Foryst-Ludwig A, Gohlke S, Li C, Flores RE, Kintscher U, Schupp M, Schulz TJ, Scholz H |
Diabetologia | 2021 |
Cyanidin-3-O-glucoside Regulates the Expression of Ucp1 in Brown Adipose Tissue by Activating Prdm16 Gene.
Han S, Yang Y, Lu Y, Guo J, Han X, Gao Y, Huang W, You Y, Zhan J |
2021 | |
Postnatal exercise protects offspring from high-fat diet-induced reductions in subcutaneous adipocyte beiging in C57Bl6/J mice
Claycombe-Larson KJ, Bundy A, Lance EB, Darland DC, Casperson SL, Roemmich JN |
The Journal of Nutritional Biochemistry | 2021 |
Irisin-Associated Neuroprotective and Rehabilitative Strategies for Stroke.
Huberman MA, d'Adesky ND, Niazi QB, Perez-Pinzon MA, Bramlett HM, Raval AP |
NeuroMolecular Medicine | 2021 |
Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice.
Teijeiro A, Garrido A, Ferre A, Perna C, Djouder N |
Nature metabolism | 2021 |
Long-term intermittent cold exposure affects peri-ovarian adipose tissue and ovarian microenvironment in rats
Zhang L, An G, Wu S, Wang J, Yang D, Zhang Y, Li X |
Journal of Ovarian Research | 2021 |
HOXC10 Suppresses Browning to Maintain White Adipocyte Identity
Tan HY, Sim MF, Tan SX, Ng Y, Gan SY, Li H, Neo SP, Gunaratne J, Xu F, Han W |
Diabetes | 2021 |
Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system beyond thermogenic adipose tissues
Claflin KE, Flippo KH, Sullivan AI, Naber MC, Zhou B, Neff TJ, Jensen-Cody SO, Potthoff MJ |
Molecular Metabolism | 2021 |
The relation of omentin gene expression and glucose homeostasis of visceral and subcutaneous adipose tissues in non-diabetic adults.
Daneshafrooz A, Yuzbashian E, Zarkesh M, Asghari G, Mirmiran P, Hedayati M, Abooshahab R, Fanaei SM, Khalaj A |
Molecular Biology Reports | 2021 |
The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, Philip A. Kern |
Journal of Clinical Investigation | 2020 |
ASK1 inhibits browning of white adipose tissue in obesity
FC Lucchini, S Wueest, TD Challa, F Item, S Modica, M Borsigova, Y Haim, C Wolfrum, A Rudich, D Konrad |
Nature Communications | 2020 |
The Beta3 Adrenergic Receptor in Healthy and Pathological Cardiovascular Tissues
LY Michel, C Farah, JL Balligand |
Cells | 2020 |
Insulin/Glucose-Responsive Cells Derived from Induced Pluripotent Stem Cells: Disease Modeling and Treatment of Diabetes
S Gheibi, T Singh, JP da Cunha, M Fex, H Mulder |
Cells | 2020 |
Beige Fat Maintenance; Toward a Sustained Metabolic Health
A Rabiee |
Frontiers in Endocrinology | 2020 |
Effect of Thyroid Hormones on Adipose Tissue Flexibility
L Volke, K Krause |
European Thyroid Journal | 2020 |
Egr1 loss-of-function promotes beige adipocyte differentiation and activation specifically in inguinal subcutaneous white adipose tissue
M Bléher, B Meshko, I Cacciapuoti, R Gergondey, Y Kovacs, D Duprez, A LHonoré, E Havis |
Scientific Reports | 2020 |
There and Back Again: Leptin Actions in White Adipose Tissue
N Martínez-Sánchez |
International journal of molecular sciences | 2020 |
Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease
X Li, H Wang |
Cell & Bioscience | 2020 |
A MicroRNA Linking Human Positive Selection and Metabolic Disorders
L Wang, N Sinnott-Armstrong, A Wagschal, AR Wark, JP Camporez, RJ Perry, F Ji, Y Sohn, J Oh, S Wu, J Chery, BN Moud, A Saadat, SN Dankel, G Mellgren, DS Tallapragada, SM Strobel, MJ Lee, R Tewhey, PC Sabeti, A Schaefer, A Petri, S Kauppinen, RT Chung, A Soukas, J Avruch, SK Fried, H Hauner, RI Sadreyev, GI Shulman, M Claussnitzer, AM Näär |
Cell | 2020 |
TSH promotes adiposity by inhibiting the browning of white fat
J Zhang, H Wu, S Ma, L Gao, C Yu, F Jing, J Zhao |
Adipocyte | 2020 |
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease
A Chait, LJ den Hartigh |
Frontiers in Cardiovascular Medicine | 2020 |
Adipose stem cells in obesity: challenges and opportunities
S Shin, AS El-Sabbagh, BE Lukas, SJ Tanneberger, Y Jiang |
Bioscience Reports | 2020 |
Thermogenic adipocytes: lineage, function and therapeutic potential
AE Pollard, D Carling |
Biochemical Journal | 2020 |
TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice
P Tougaard, LO Martinsen, DO Lützhøft, HE Jensen, M Flethøj, P Vandenabeele, AE Pedersen, S Skov, AK Hansen, CH Hansen |
International Journal of Obesity | 2020 |
The effect of TGFβ1 on thermogenic markers is dependent on the degree of adipocyte differentiation
BR Maharjan, SV McLennan, SM Twigg, PF Williams |
Bioscience Reports | 2020 |
The biology of lipid droplet-bound mitochondria
M Veliova, A Petcherski, M Liesa, OS Shirihai |
Seminars in Cell & Developmental Biology | 2020 |
Palmitoleic Acid Decreases Non-alcoholic Hepatic Steatosis and Increases Lipogenesis and Fatty Acid Oxidation in Adipose Tissue From Obese Mice
MM Cruz, JJ Simão, RD de Sá, TS Farias, VS da Silva, F Abdala, VJ Antraco, L Armelin-Correa, MI Alonso-Vale |
Frontiers in Endocrinology | 2020 |
Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
AJ Knights, EJ Vohralik, PJ Houweling, ES Stout, LJ Norton, SJ Alexopoulos, JJ Yik, HM Jusoh, EM Olzomer, KS Bell-Anderson, KN North, KL Hoehn, M Crossley, KG Quinlan |
Nature Communications | 2020 |
Chronic arsenic exposure impairs adaptive thermogenesis in male C57BL/6J mice
F Castriota, PJ Zushin, SS Sanchez, RV Phillips, A Hubbard, A Stahl, MT Smith, JC Wang, MA Merrill |
American journal of physiology. Endocrinology and metabolism | 2020 |
Mark4 Inhibited the Browning of White Adipose Tissue by Promoting Adipocytes Autophagy in Mice
K Yang, J Cai, M Pan, Q Sun, C Sun |
International journal of molecular sciences | 2020 |
Feeding brown fat: dietary phytochemicals targeting non-shivering thermogenesis to control body weight
C Horvath, C Wolfrum |
Proceedings of the Nutrition Society | 2020 |
Do Bariatric Surgeries Enhance Brown/Beige Adipose Tissue Thermogenesis?
MK Hankir, F Seyfried |
Frontiers in Endocrinology | 2020 |
Metabolic Improvement via Enhancing Thermogenic Fat-Mediated Non-shivering Thermogenesis: From Rodents to Humans
R Pan, X Zhu, P Maretich, Y Chen |
Frontiers in Endocrinology | 2020 |
Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis
C Xing, D Jiang, Y Liu, Q Tang, H Huang |
Genes & Diseases | 2020 |
Bisphenol AF promotes inflammation in human white adipocytes
N Chernis, P Masschelin, AR Cox, SM Hartig |
American journal of physiology. Cell physiology | 2020 |
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue
B Li, M Zhang, Y Duan, L Shuai, H Jiang, J Li, F Nan, J Li |
Acta Pharmacologica Sinica | 2020 |
PRDM16 orchestrates angiogenesis via neural differentiation in the developing brain
L Su, X Lei, H Ma, C Feng, J Jiang, J Jiao |
Cell Death and Differentiation | 2020 |
The metabolic effects of mirabegron are mediated primarily by β 3 ‐adrenoceptors
N Dehvari, M Sato, MH Bokhari, A Kalinovich, S Ham, J Gao, HT Nguyen, L Whiting, S Mukaida, J Merlin, LY Chia, D Wootten, RJ Summers, BA Evans, T Bengtsson, DS Hutchinson |
Pharmacology Research & Perspectives | 2020 |
Genetic background and diet affect brown adipose gene coexpression networks associated with metabolic phenotypes
C Carson, HA Lawson |
Physiological genomics | 2020 |
Studying Brown Adipose Tissue in a Human in vitro Context
I Samuelson, A Vidal-Puig |
Frontiers in Endocrinology | 2020 |
Depot-specific UCP1 expression in human white adipose tissue and its association with obesity-related markers
J Lim, HS Park, J Kim, YJ Jang, JH Kim, YJ Lee, Y Heo |
International Journal of Obesity | 2020 |
An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models
MJ Choi, SB Jung, SE Lee, SG Kang, JH Lee, MJ Ryu, HK Chung, JY Chang, YK Kim, HJ Hong, H Kim, HJ Kim, CH Lee, A Mardinoglu, HS Yi, M Shong |
Diabetologia | 2020 |
Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice
DH Lee, SH Chang, DK Yang, NJ Song, UJ Yun, KW Park |
Nutrients | 2020 |
CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling
Y Oguri, K Shinoda, H Kim, DL Alba, WR Bolus, Q Wang, Z Brown, RN Pradhan, K Tajima, T Yoneshiro, K Ikeda, Y Chen, RT Cheang, K Tsujino, CR Kim, VJ Greiner, R Datta, CD Yang, K Atabai, MT McManus, SK Koliwad, BM Spiegelman, S Kajimura |
Cell | 2020 |
UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes
K Ikeda, T Yamada |
Frontiers in Endocrinology | 2020 |
Browning capabilities of human primary adipose-derived stromal cells compared to SGBS cells
D Halbgebauer, M Dahlhaus, M Wabitsch, P Fischer-Posovszky, D Tews |
Scientific Reports | 2020 |
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice
Y Wang, M Gao, F Zhu, X Li, Y Yang, Q Yan, L Jia, L Xie, Z Chen |
Nature Communications | 2020 |
Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis
A Fenzl, OC Kulterer, K Spirk, G Mitulović, R Marculescu, M Bilban, S Baumgartner-Parzer, A Kautzky-Willer, L Kenner, J Plutzky, L Quadro, FW Kiefer |
Molecular Metabolism | 2020 |
Calsyntenin 3β Is Dynamically Regulated by Temperature in Murine Brown Adipose and Marks Human Multilocular Fat
K Plucińska, NZ Jespersen, EL Brown, PS Petersen, K Rupar, S Nielsen, C Scheele, B Emanuelli |
Frontiers in Endocrinology | 2020 |
miR-30a targets gene networks that promote browning of human and mouse adipocytes
PK Saha, MP Hamilton, K Rajapakshe, V Putluri, JB Felix, P Masschelin, AR Cox, M Bajaj, N Putluri, C Coarfa, SM Hartig |
American journal of physiology. Endocrinology and metabolism | 2020 |
Combating Obesity With Thermogenic Fat: Current Challenges and Advancements
R Pan, X Zhu, P Maretich, Y Chen |
Frontiers in Endocrinology | 2020 |
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
C Ruocco, M Ragni, F Rossi, P Carullo, V Ghini, F Piscitelli, A Cutignano, E Manzo, RM Ioris, F Bontems, L Tedesco, CM Greco, A Pino, I Severi, D Liu, RP Ceddia, L Ponzoni, L Tenori, L Rizzetto, M Scholz, K Tuohy, F Bifari, VD Marzo, C Luchinat, MO Carruba, S Cinti, I Decimo, G Condorelli, R Coppari, S Collins, A Valerio, E Nisoli |
Diabetes | 2020 |
The PPAR Ω Pocket: Renewed Opportunities for Drug Development
Å Kaupang, TV Hansen |
PPAR Research | 2020 |
Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
AE Pravednikova, SY Shevchenko, VV Kerchev, MR Skhirtladze, SN Larina, ZM Kachaev, AD Egorov, YV Shidlovskii |
Molecular Medicine | 2020 |
Multiple roles of HOX proteins in Metastasis: Let me count the ways
J Jonkers, P Pai, S Sukumar |
Cancer and Metastasis Reviews | 2020 |
γδT cells and adipocyte IL-17RC control fat innervation and thermogenesis
Hu B, Jin C, Zeng X, Resch JM, Jedrychowski MP, Yang Z, Desai BN, Banks AS, Lowell BB, Mathis D, Spiegelman BM |
Nature | 2020 |
Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice.
Wang H, Kuusela S, Rinnankoski-Tuikka R, Dumont V, Bouslama R, Ramadan UA, Waaler J, Linden AM, Chi NW, Krauss S, Pirinen E, Lehtonen S |
International Journal of Obesity | 2020 |
Dietary Silk Peptide Prevents High-Fat Diet-Induced Obesity and Promotes Adipose Browning by Activating AMP-Activated Protein Kinase in Mice.
Lee K, Jin H, Chei S, Lee JY, Oh HJ, Lee BY |
Nutrients | 2020 |
Exercise-Induced Adaptations to Adipose Tissue Thermogenesis
Vidal P, Stanford KI |
Frontiers in Endocrinology | 2020 |
Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue
Patel BV, Yao F, Howenstine A, Takenaka R, Hyatt JA, Sears KE, Shewchuk BM |
Journal of Molecular Biology | 2020 |
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Zhang J, Yang J, Yang N, Ma J, Lu D, Dong Y, Liang H, Liu D, Cang M |
Lipids in Health and Disease | 2020 |
PVAT: an important guardian of the cardiovascular system.
Liang X, Qi Y, Dai F, Gu J, Yao W |
Histology and histopathology | 2020 |
Use of Infrared Thermography to Estimate Brown Fat Activation After a Cooling Protocol in Patients with Severe Obesity That Underwent Bariatric Surgery.
Piquer-Garcia I, Cereijo R, Corral-Pérez J, Pellitero S, Martínez E, Taxerås SD, Tarascó J, Moreno P, Balibrea J, Puig-Domingo M, Serra D, Herrero L, Jiménez-Pavón D, Lerin C, Villarroya F, Sánchez-Infantes D |
Obesity surgery | 2020 |
Allicin Regulates Energy Homeostasis through Brown Adipose Tissue.
Zhang C, He X, Sheng Y, Xu J, Yang C, Zheng S, Liu J, Li H, Ge J, Yang M, Zhai B, Xu W, Luo Y, Huang K |
iScience | 2020 |
Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo
Markan KR, Boland LK, King-McAlpin AQ, Claflin KE, Leaman MP, Kemerling MK, Stonewall MM, Amendt BA, Ankrum JA, Potthoff MJ |
Molecular Metabolism | 2020 |
Functions of Circular RNAs in Regulating Adipogenesis of Mesenchymal Stem Cells
Wang F, Li X, Li Z, Wang S, Fan J |
Stem Cells International | 2020 |
DNA Methylation Changes are Associated with the Programming of White Adipose Tissue Browning Features by Resveratrol and Nicotinamide Riboside Neonatal Supplementations in Mice
Serrano A, Asnani-Kishnani M, Couturier C, Astier J, Palou A, Landrier JF, Ribot J, Bonet ML |
Nutrients | 2020 |
PPARγ and PPARα synergize to induce robust browning of white fat in vivo
Kroon T, Harms M, Maurer S, Bonnet L, Alexandersson I, Lindblom A, Ahnmark A, Nilsson D, Gennemark P, O'Mahony G, Osinski V, McNamara C, Boucher J |
Molecular Metabolism | 2020 |
How does your fat affect your liver when you drink?
Seonghwan Hwang, Bin Gao |
Journal of Clinical Investigation | 2019 |
Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans
L Wu, M Xia, Y Duan, L Zhang, H Jiang, X Hu, H Yan, Y Zhang, Y Gu, H Shi, J Li, X Gao, J Li |
Cell Death and Disease | 2019 |
Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue
LY Chia, BA Evans, S Mukaida, T Bengtsson, DS Hutchinson, M Sato |
British Journal of Pharmacology | 2019 |
The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression
Corrêa, Heyn, Magalhaes |
Cells | 2019 |
Cytokines and Abnormal Glucose and Lipid Metabolism
J Shi, J Fan, Q Su, Z Yang |
Frontiers in Endocrinology | 2019 |
Neuroendocrine Regulation of Energy Metabolism Involving Different Types of Adipose Tissues
Q Zhu, BJ Glazier, BC Hinkel, J Cao, L Liu, C Liang, H Shi |
International journal of molecular sciences | 2019 |
Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism
C Scheele, C Wolfrum |
Endocrine reviews | 2019 |
Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging
T Mau, M OBrien, AK Ghosh, RA Miller, R Yung, DL Couteur |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2019 |
Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome
LI Arhire, L Mihalache, M Covasa |
Frontiers in Endocrinology | 2019 |
Rosiglitazone remodels the lipid droplet and britens human visceral and subcutaneous adipocytes ex vivo
MJ Lee, S Jash, JE Jones, V Puri, SK Fried |
Journal of lipid research | 2019 |
The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases
Lee, Park, Oh, Lee, Kim, Bae |
International journal of molecular sciences | 2019 |
Consumption of out-of-season orange modulates fat accumulation, morphology and gene expression in the adipose tissue of Fischer 344 rats
A Gibert-Ramos, H Palacios-Jordan, MJ Salvadó, A Crescenti |
European Journal of Nutrition | 2019 |
A Lipophilic Fucoxanthin-Rich Phaeodactylum tricornutum Extract Ameliorates Effects of Diet-Induced Obesity in C57BL/6J Mice
A Gille, B Stojnic, F Derwenskus, A Trautmann, U Schmid-Staiger, C Posten, K Briviba, A Palou, M Bonet, J Ribot |
Nutrients | 2019 |
Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice
L Zhao, B Wang, NA Gomez, JM de Avila, MJ Zhu, M Du |
International Journal of Obesity | 2019 |
Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue: Exercise, nutrition and the circadian clock
L Dollet, JR Zierath |
The Journal of Physiology | 2019 |
Neonatal Resveratrol and Nicotinamide Riboside Supplementations Sex-Dependently Affect Beige Transcriptional Programming of Preadipocytes in Mouse Adipose Tissue
M Asnani-Kishnani, AM Rodríguez, A Serrano, A Palou, ML Bonet, J Ribot |
Frontiers in physiology | 2019 |
Trans-Cinnamic Acid Stimulates White Fat Browning and Activates Brown Adipocytes
N Kang, S Mukherjee, J Yun |
Nutrients | 2019 |
3,5 Diiodo-l-Thyronine (T2) Promotes the Browning of White Adipose Tissue in High-Fat Diet-Induced Overweight Male Rats Housed at Thermoneutrality
R Senese, F Cioffi, RD Matteis, G Petito, P de Lange, E Silvestri, A Lombardi, M Moreno, F Goglia, A Lanni |
Cells | 2019 |
The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity
M Namwanje, L Liu, M Chan, N Aaron, MJ Kraakman, L Qiang |
Journal of Endocrinology | 2019 |
Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells
NZ Jespersen, A Feizi, ES Andersen, S Heywood, HB Hattel, S Daugaard, L Peijs, P Bagi, B Feldt-Rasmussen, HS Schultz, NS Hansen, R Krogh-Madsen, BK Pedersen, N Petrovic, S Nielsen, C Scheele |
Molecular Metabolism | 2019 |
Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration
JA Deis, H Guo, Y Wu, C Liu, DA Bernlohr, X Chen |
Molecular Metabolism | 2019 |
Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures
S Muller, I Ader, J Creff, H Leménager, P Achard, L Casteilla, L Sensebé, A Carrière, F Deschaseaux |
Scientific Reports | 2019 |
Identification of a natural beige adipose depot in mice
M Chan, YC Lim, J Yang, M Namwanje, L Liu, L Qiang |
The Journal of biological chemistry | 2019 |
Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis
X Zeng, M Ye, JM Resch, MP Jedrychowski, B Hu, BB Lowell, DD Ginty, BM Spiegelman |
Nature | 2019 |
Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway
J Wang, J Ge, H Cao, X Zhang, Y Guo, X Li, B Xia, G Yang, X Shi |
Cells | 2019 |
Adrenoceptors in white, brown, and brite adipocytes
BA Evans, J Merlin, T Bengtsson, DS Hutchinson |
British Journal of Pharmacology | 2019 |
Ca 2+ entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex
A Schaar, Y Sun, P Sukumaran, TA Rosenberger, D Krout, JN Roemmich, L Brinbaumer, K Claycombe-Larson, BB Singh |
Journal of cell science | 2019 |
Resting Energy Expenditure, Insulin Resistance and UCP1 Expression in Human Subcutaneous and Visceral Adipose Tissue of Patients With Obesity
S Bettini, F Favaretto, C Compagnin, A Belligoli, M Sanna, R Fabris, R Serra, CD Prà, L Prevedello, M Foletto, R Vettor, G Milan, L Busetto |
Frontiers in Endocrinology | 2019 |
PRDM16 Represses the Pig White Lipogenesis through Promoting Lipolysis Activity
T Gu, G Xu, C Jiang, L Hou, Z Wu, C Wang |
BioMed Research International | 2019 |
Dynamics of transcriptome changes during subcutaneous preadipocyte differentiation in ducks
Z Wang, ZT Yin, F Zhang, XQ Li, SR Chen, N Yang, TE Porter, Z Hou |
BMC Genomics | 2019 |
Cold-induced lipid dynamics and transcriptional programs in white adipose tissue
Z Xu, W You, Y Zhou, W Chen, Y Wang, T Shan |
BMC Biology | 2019 |
Cellular Origins of Beige Fat Cells Revisited
M Shao, QA Wang, A Song, L Vishvanath, NC Busbuso, PE Scherer, RK Gupta |
Diabetes | 2019 |
Activation of NPRs and UCP1-independent pathway following CB1R antagonist treatment is associated with adipose tissue beiging in fat-fed male dogs
MS Iyer, RL Paszkiewicz, RN Bergman, JM Richey, OO Woolcott, I Asare-Bediako, Q Wu, SP Kim, D Stefanovski, CM Kolka, DJ Clegg, M Kabir |
American journal of physiology. Endocrinology and metabolism | 2019 |
Cold Induced Depot-Specific Browning in Ferret Aortic Perivascular Adipose Tissue
B Reynés, EM van Schothorst, J Keijer, E Ceresi, P Oliver, A Palou |
Frontiers in physiology | 2019 |
Gain of Metabolic Benefit with Ablation of miR-149-3p from Subcutaneous Adipose Tissue in Diet-Induced Obese Mice
S Zheng, S Guo, G Sun, Y Shi, Z Wei, Y Tang, F He, C Shi, P Dai, H Chong, I Samuelson, K Zen, CY Zhang, Y Zhang, J Li, X Jiang |
Molecular Therapy — Nucleic Acids | 2019 |
Bitter Orange (Citrus aurantium Linné) Improves Obesity by Regulating Adipogenesis and Thermogenesis through AMPK Activation
Park, Kim, Jung, Ahn, Kwak, Um |
Nutrients | 2019 |
Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy
CR Dechandt, GD Ferrari, JR dos Santos, JA de Oliveira, RM da Silva-Jr, AO Cunha, N Garcia-Cairasco, LC Alberici |
Frontiers in neurology | 2019 |
Reaffirmation of known major genes and the identification of novel candidate genes associated with carcass-related metrics based on whole genome sequence within a large multi-breed cattle population
DC Purfield, RD Evans, DP Berry |
BMC Genomics | 2019 |
Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice
H Li, C Zhang, J Liu, W Xie, W Xu, F Liang, K Huang, X He, K Sun |
PloS one | 2019 |
Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway
W Sun, X Zhao, Z Wang, Y Chu, L Mao, S Lin, X Gao, Y Song, X Hui, S Jia, S Tang, Y Xu, A Xu, K Loomes, C Wang, D Wu, T Nie |
Molecular Metabolism | 2019 |
Myricanol modulates skeletal muscle–adipose tissue crosstalk to alleviate high‐fat diet‐induced obesity and insulin resistance
S Shen, Q Liao, T Zhang, R Pan, L Lin |
British Journal of Pharmacology | 2019 |
A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate
W Wang, J Ishibashi, S Trefely, M Shao, AJ Cowan, A Sakers, HW Lim, S OConnor, MT Doan, P Cohen, JA Baur, MT King, RL Veech, KJ Won, JD Rabinowitz, NW Snyder, RK Gupta, P Seale |
Cell Metabolism | 2019 |
Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice
YC Jung, HW Kim, BK Min, JY Cho, HJ Son, JY Lee, JY Kim, SB Kwon, Q Li, HW Lee |
In vivo (Athens, Greece) | 2019 |
Towards a Better Understanding of Beige Adipocyte Plasticity
E Paulo, B Wang |
Cells | 2019 |
Black Ginseng and Ginsenoside Rb1 Promote Browning by Inducing UCP1 Expression in 3T3-L1 and Primary White Adipocytes
SJ Park, M Park, A Sharma, K Kim, HJ Lee |
Nutrients | 2019 |
White Adipocyte Plasticity in Physiology and Disease
E Bielczyk-Maczynska |
Cells | 2019 |
ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice
L Wei, M Surma, Y Yang, S Tersey, J Shi |
The FASEB Journal | 2019 |
MicroRNA‐188 regulates aging‐associated metabolic phenotype
Y Huang, Y Xiao, Y Liu, M Guo, Q Guo, F Zhou, T Liu, T Su, Y Xiao, XH Luo |
Aging Cell | 2019 |
QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity
H Lu, Z Ye, Y Zhai, L Wang, Y Liu, J Wang, W Zhang, W Luo, Z Lu, J Chen |
EMBO reports | 2019 |
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
RR Stine, AP Sakers, T TeSlaa, M Kissig, ZE Stine, CW Kwon, L Cheng, HW Lim, KH Kaestner, JD Rabinowitz, P Seale |
Cell Stem Cell | 2019 |
Relationships between expression levels of genes related to adipogenesis and adipocyte function in dogs.
Motomura M, Shimokawa F, Kobayashi T, Yamashita Y, Mizoguchi I, Sato Y, Murakami Y, Shimizu I, Matsui T, Murakami M, Funaba M |
Molecular Biology Reports | 2019 |
CD8+ T cells in beige adipogenesis and energy homeostasis
Maria Moysidou, Sevasti Karaliota, Elisavet Kodela, Maria Salagianni, yassemi koutmani, Antonia Katsouda, Konstantia Kodela, Panagiotis Tsakanikas, Styliani Ourailidou, Evangelos Andreakos, Nikos Kostomitsopoulos, Dimitris Skokos, Antonios Chatzigeorgiou, Kyoung-Jin Chung, Stefan Bornstein, Mark Sleeman, Triantafyllos Chavakis, katia karalis |
JCI Insight | 2018 |
Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A
K Ueda, E Takimoto, Q Lu, P Liu, N Fukuma, Y Adachi, R Suzuki, S Chou, W Baur, MJ Aronovitz, AS Greenberg, I Komuro, RH Karas |
Diabetes | 2018 |
miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity
EH Koh, N Chernis, PK Saha, L Xiao, DA Bader, B Zhu, K Rajapakshe, MP Hamilton, X Liu, D Perera, , B York, M Trauner, C Coarfa, M Bajaj, DD Moore, T Deng, SE McGuire, SM Hartig |
Diabetes | 2018 |
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism
P Pathak, C Xie, RG Nichols, JM Ferrell, S Boehme, KW Krausz, AD Patterson, FJ Gonzalez, JY Chiang |
Hepatology | 2018 |
Adipose tissue and the physiologic underpinnings of metabolic disease
RW O'Rourke |
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery | 2018 |
CDK6 inhibits white to beige fat transition by suppressing RUNX1
X Hou, Y Zhang, W Li, AJ Hu, C Luo, W Zhou, JK Hu, SG Daniele, J Wang, J Sheng, Y Fan, AS Greenberg, SR Farmer, MG Hu |
Nature Communications | 2018 |
PVAT and Its Relation to Brown, Beige, and White Adipose Tissue in Development and Function
S Hildebrand, J Stümer, A Pfeifer |
Frontiers in physiology | 2018 |
Transcriptional Control of Brown and Beige Fat Development and Function: Beige Fat Development and Function
SN Shapira, P Seale |
Obesity | 2018 |
Brown Adipose Tissue
A Pfeifer, M Klingenspor, S Herzig |
2018 | |
Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity
MT Rached, SJ Millership, SM Pedroni, AI Choudhury, AS Costa, DG Hardy, JA Glegola, EE Irvine, C Selman, MC Woodberry, VK Yadav, S Khadayate, A Vidal-Puig, S Virtue, C Frezza, DJ Withers |
Molecular Metabolism | 2018 |
Electric stimulation of ears accelerates body weight loss mediated by high-fat to low-fat diet switch accompanied by increased white adipose tissue browning in C57BL/6 J mice
SH Chen, HC Chen, CL Hsieh, PM Chao |
BMC complementary and alternative medicine | 2018 |
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance
B Wang, K Cheng |
International journal of molecular sciences | 2018 |
Wnt/β-Catenin Signaling and Obesity
N Chen, J Wang |
Frontiers in physiology | 2018 |
Perivascular Adipose Tissue as a Relevant Fat Depot for Cardiovascular Risk in Obesity
RM Costa, KB Neves, RC Tostes, NS Lobato |
Frontiers in physiology | 2018 |
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation
Y Igarashi, A Nawaz, T Kado, M Bilal, T Kuwano, S Yamamoto, M Sasahara, X Jiuxiang, A Inujima, K Koizumi, J Imura, N Shibahara, I Usui, S Fujisaka, K Tobe |
Scientific Reports | 2018 |
Development, activation, and therapeutic potential of thermogenic adipocytes
MP Emont, D Kim, J Wu |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2018 |
Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning
J Han, Q Meng, L Shen, G Wu |
Lipids in Health and Disease | 2018 |
Looking on the “brite” side exercise-induced browning of white adipose tissue
LK Townsend, DC Wright |
Pflügers Archiv - European Journal of Physiology | 2018 |
Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity
E Paulo, D Wu, P Hecker, Y Zhang, B Wang |
Journal of Endocrinology | 2018 |
HDAC3-selective inhibition activates brown and beige fat through PRDM16
J Liao, J Jiang, H Jun, X Qiao, MP Emont, D Kim, J Wu |
Endocrinology | 2018 |
Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis
Y Hasegawa, K Ikeda, Y Chen, DL Alba, D Stifler, K Shinoda, T Hosono, P Maretich, Y Yang, Y Ishigaki, J Chi, P Cohen, SK Koliwad, S Kajimura |
Cell Metabolism | 2018 |
Functional role of ADAMTS5 in adiposity and metabolic health
D Bauters, P Bedossa, HR Lijnen, B Hemmeryckx, V Souza-Mello |
PloS one | 2018 |
Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans
M Stadion, K Schwerbel, A Graja, C Baumeier, M Rödiger, W Jonas, C Wolfrum, H Staiger, A Fritsche, HU Häring, N Klöting, M Blüher, P Fischer-Posovszky, TJ Schulz, HG Joost, H Vogel, A Schürmann |
Diabetologia | 2018 |
Dendritic peptide bolaamphiphiles for siRNA delivery to primary adipocytes
AC Eldredge, ME Johnson, Y Cao, L Zhang, C Zhao, Z Liu, Q Yang, Z Guan |
Biomaterials | 2018 |
Metabolic benefits of inhibition of p38α in white adipose tissue in obesity
S Zhang, H Cao, Y Li, Y Jing, S Liu, C Ye, H Wang, S Yu, C Peng, L Hui, Y Wang, H Zhang, F Guo, Q Zhai, H Wang, R Huang, L Zhang, J Jiang, W Liu, H Ying, G Hotamisligil |
PLoS Biology | 2018 |
Derivation and characterization of a UCP1 reporter human ES cell line
S Mukherjee, T Zhang, LA Lacko, L Tan, JZ Xiang, JM Butler, S Chen |
Stem Cell Research | 2018 |
The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting
S Elattar, M Dimri, A Satyanarayana |
The FASEB Journal | 2018 |
Rosiglitazone and a β3-Adrenoceptor Agonist Are Both Required for Functional Browning of White Adipocytes in Culture
J Merlin, M Sato, LY Chia, R Fahey, M Pakzad, CJ Nowell, RJ Summers, T Bengtsson, BA Evans, DS Hutchinson |
Frontiers in Endocrinology | 2018 |
Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis
Q Chen, L Huang, D Pan, LJ Zhu, YX Wang |
Cell Reports | 2018 |
Molecular signatures and functional analysis of beige adipocytes induced from in vivo intra-abdominal adipocytes
H Xue, Z Wang, Y Hua, S Ke, Y Wang, J Zhang, YH Pan, W Huang, DM Irwin, S Zhang |
Science Advances | 2018 |
TGF-β receptor 1 regulates progenitors that promote browning of white fat
UD Wankhade, JH Lee, PK Dagur, H Yadav, M Shen, W Chen, AB Kulkarni, JP McCoy, T Finkel, AM Cypess, SG Rane |
Molecular Metabolism | 2018 |
Genetic and epigenetic control of adipose development
O Gulyaeva, J Dempersmier, HS Sul |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2018 |
PRDM16 Gene Polymorphism Is Associated with Obesity and Blood Lipids Profiles in Saudi Population
A AlAmrani, M AbdelKarim, M AlZoghaibi |
Journal of Clinical Medicine | 2018 |
cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis
YS Yoon, WW Tsai, SV de Velde, Z Chen, KF Lee, DA Morgan, K Rahmouni, S Matsumura, E Wiater, Y Song, M Montminy |
Proceedings of the National Academy of Sciences | 2018 |
PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice
NJ Song, SH Chang, S Kim, V Panic, BH Jang, UJ Yun, JH Choi, Z Li, KM Park, JH Yoon, S Kim, JH Yoo, J Ling, K Thomas, CJ Villanueva, DY Li, JY Ahn, JM Ku, KW Park |
Cell Death and Disease | 2018 |
Assessment of the Aging of the Brown Adipose Tissue by 18 F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna −/−
Z Wang, X Xu, Y Liu, Y Gao, F Kang, B Liu, J Wang |
Contrast Media & Molecular Imaging | 2018 |
Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1
T Zou, B Wang, Q Yang, JM de Avila, MJ Zhu, J You, D Chen, M Du |
The Journal of Nutritional Biochemistry | 2018 |
The Common and Distinct Features of Brown and Beige Adipocytes
K Ikeda, P Maretich, S Kajimura |
Trends in endocrinology and metabolism: TEM | 2018 |
Crotamine induces browning of adipose tissue and increases energy expenditure in mice
MP Marinovic, JD Campeiro, SC Lima, AL Rocha, MB Nering, EB Oliveira, MA Mori, MA Hayashi |
Scientific Reports | 2018 |
Brown Adipose Tissue Energy Metabolism in Humans
AC Carpentier, DP Blondin, KA Virtanen, D Richard, F Haman, ÉE Turcotte |
Frontiers in Endocrinology | 2018 |
Expression levels of brown/beige adipocyte-related genes in fat depots of vitamin A-restricted fattening cattle1
HJ Chen, T Ihara, H Yoshioka, E Itoyama, S Kitamura, H Nagase, H Murakami, Y Hoshino, M Murakami, S Tomonaga, T Matsui, M Funaba |
Journal of animal science | 2018 |
The nuclear retinoid-related orphan receptor ROR α controls circadian thermogenic programming in white fat depots
C Monnier, M Auclair, GL Cam, MP Garcia, B Antoine |
Physiological Reports | 2018 |
Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex
X Ma, D Wang, W Zhao, L Xu |
Frontiers in Endocrinology | 2018 |
Class I and II Histone Deacetylase Inhibitors Differentially Regulate Thermogenic Gene Expression in Brown Adipocytes
A Rajan, H Shi, B Xue |
Scientific Reports | 2018 |
Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway
JS Samuels, R Shashidharamurthy, S Rayalam |
Nutrition & Metabolism | 2018 |
Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration
Q Li, Y Wu, N Kang |
Stem Cells International | 2018 |
Insights into the neurochemical signature of the Innervation of Beige Fat
A Stefanidis, NM Wiedmann, S Tyagi, AM Allen, MJ Watt, BJ Oldfield |
Molecular Metabolism | 2018 |
Association of serum concentrations of irisin and the adipokines adiponectin and leptin with epicardial fat in cardiovascular surgery patients
H Kaneda, T Nakajima, A Haruyama, I Shibasaki, T Hasegawa, T Sawaguchi, T Kuwata, S Obi, T Arikawa, M Sakuma, H Amano, S Toyoda, H Fukuda, T Inoue, L Vanella |
PloS one | 2018 |
Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes
K Lee, YJ Seo, JH Song, BY Lee |
Journal of Ginseng Research | 2018 |
Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes
DF Pisani, V Barquissau, JC Chambard, D Beuzelin, RA Ghandour, M Giroud, A Mairal, S Pagnotta, S Cinti, D Langin, EZ Amri |
Molecular Metabolism | 2018 |
Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes
VD Ramseyer, VA Kimler, JG Granneman |
Molecular Metabolism | 2018 |
Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway
X Zhang, Y Luo, C Wang, X Ding, X Yang, D Wu, F Silva, Z Yang, Q Zhou, L Wang, X Wang, J Zhou, N Boyd, M Spafford, M Burge, XO Yang, M Liu |
Cell Reports | 2018 |
The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice
K Takeda, H Sawazaki, H Takahashi, YS Yeh, HF Jheng, W Nomura, T Ara, N Takahashi, S Seno, N Osato, H Matsuda, T Kawada, T Goto |
FEBS Open Bio | 2018 |
Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes
A Kaisanlahti, T Glumoff |
Journal of Physiology and Biochemistry | 2018 |
Thermal stress induces glycolytic beige fat formation via a myogenic state
Y Chen, K Ikeda, T Yoneshiro, A Scaramozza, K Tajima, Q Wang, K Kim, K Shinoda, CH Sponton, Z Brown, A Brack, S Kajimura |
Nature | 2018 |
Genome-wide identification and characterization of long non-coding RNAs during postnatal development of rabbit adipose tissue
GZ Wang, K Du, SQ Hu, SY Chen, XB Jia, MC Cai, Y Shi, J Wang, SJ Lai |
Lipids in Health and Disease | 2018 |
Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue
V Pellegrinelli, VJ Peirce, L Howard, S Virtue, D Türei, M Senzacqua, A Frontini, JW Dalley, AR Horton, G Bidault, I Severi, A Whittle, K Rahmouni, J Saez-Rodriguez, S Cinti, AM Davies, A Vidal-Puig |
Nature Communications | 2018 |
Deletion of p22phox-dependent oxidative stress in the hypothalamus protects against obesity by modulating β3-adrenergic mechanisms
Heinrich Lob, Jiunn Song, Chansol Hurr, Alvin Chung, Colin Young, Allyn L Mark, Robin Davisson |
JCI Insight | 2017 |
Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions
Xiaoyan Yang, Wenhai Sui, Meng Zhang, Mei Dong, Sharon Lim, Takahiro Seki, Ziheng Guo, Carina Fischer, Huixia Lu, Cheng Zhang, Jianmin Yang, Meng Zhang, Yangang Wang, Caixia Cao, Yanyan Gao, Xingguo Zhao, Meili Sun, Yuping Sun, Rujie Zhuang, Nilesh Samani, Yun Zhang, Yihai Cao |
JCI Insight | 2017 |
Comparing minimally supervised home-based and closely supervised gym-based exercise programs in weight reduction and insulin resistance after bariatric surgery: A randomized clinical trial
S Kaviani, H Dadgostar, A Mazaherinezhad, H Adib, M Solaymani-Dodaran, F Soheilipour, M Hakiminezhad |
Medical journal of the Islamic Republic of Iran | 2017 |
White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
YW Chung, F Ahmad, Y Tang, SC Hockman, HJ Kee, K Berger, E Guirguis, YH Choi, DM Schimel, AM Aponte, S Park, E Degerman, VC Manganiello |
Scientific Reports | 2017 |
Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice
C Milet, M Bléher, K Allbright, M Orgeur, F Coulpier, D Duprez, E Havis |
Scientific Reports | 2017 |
Tissue Immunometabolism: Development, Physiology, and Pathobiology
K Man, VI Kutyavin, A Chawla |
Cell Metabolism | 2017 |
Thermogenic Fat
J Wu |
Thermogenic Fat | 2017 |
Metabolic regulation and the anti-obesity perspectives of human brown fat
C Scheele, S Nielsen |
Redox Biology | 2017 |
Deciphering adipose tissue heterogeneity: Adipose tissue heterogeneity
MD Lynes, YH Tseng |
Annals of the New York Academy of Sciences | 2017 |
Shortcuts to a functional adipose tissue: The role of small non-coding RNAs
BB Brandão, BA Guerra, MA Mori |
Redox Biology | 2017 |
The dark side of browning
KA Tamucci, M Namwanje, L Fan, L Qiang |
Protein & Cell | 2017 |
Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules
NJ Song, SH Chang, DY Li, CJ Villanueva, KW Park |
Experimental & molecular medicine | 2017 |
Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into BloodNovelty and Significance
JW Williams, A Elvington, S Ivanov, S Kessler, H Luehmann, O Baba, BT Saunders, KW Kim, MW Johnson, CS Craft, JH Choi, MG Sorci-Thomas, BH Zinselmeyer, JR Brestoff, Y Liu, GJ Randolph |
Circulation research | 2017 |
Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function: Exercise, adipose tissue and vascular function
BC Boa, JS Yudkin, VW van Hinsbergh, E Bouskela, EC Eringa |
British Journal of Pharmacology | 2017 |
Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice
C Hepler, M Shao, JY Xia, AL Ghaben, MJ Pearson, L Vishvanath, AX Sharma, TS Morley, WL Holland, RK Gupta |
eLife | 2017 |
Parkin-mediated mitophagy is downregulated in browning of white adipose tissue: Parkin Downregulation in White Adipose Browning
D Taylor, RA Gottlieb |
Obesity | 2017 |
An adaptive variant of TRIB2, rs1057001, is associated with higher expression levels of thermogenic genes in human subcutaneous and visceral adipose tissues
K Nakayama, S Iwamoto |
Journal of PHYSIOLOGICAL ANTHROPOLOGY | 2017 |
Sorting out adipocyte precursors and their role in physiology and disease
C Hepler, L Vishvanath, RK Gupta |
Genes & development | 2017 |
Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes
N González, Z Moreno-Villegas, A González-Bris, J Egido, Ó Lorenzo |
Cardiovascular Diabetology | 2017 |
EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex
SN Shapira, HW Lim, S Rajakumari, AP Sakers, J Ishibashi, MJ Harms, KJ Won, P Seale |
Genes & development | 2017 |
Humans and Mice Display Opposing Patterns of “Browning” Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots
MA Zuriaga, JJ Fuster, N Gokce, K Walsh |
Frontiers in Cardiovascular Medicine | 2017 |
Lsd1 prevents age-programed loss of beige adipocytes
D Duteil, M Tosic, D Willmann, A Georgiadi, T Kanouni, R Schüle |
Proceedings of the National Academy of Sciences | 2017 |
An Additive Effect of Promoting Thermogenic Gene Expression in Mice Adipose-Derived Stromal Vascular Cells by Combination of Rosiglitazone and CL316,243
YL Li, X Li, TT Jiang, JM Fan, XL Zheng, XE Shi, TY Yu, GY Chu, GS Yang |
International journal of molecular sciences | 2017 |
Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling
D Bauters, M Cobbaut, L Geys, JV Lint, B Hemmeryckx, HR Lijnen |
Molecular Metabolism | 2017 |
Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system
K Kaineder, T Birngruber, G Rauter, B Obermüller, J Eichler, J Münzker, W Al-Zoughbi, SI Mautner, SS Torekov, B Hartmann, P Kotzbeck, TR Pieber |
International Journal of Obesity | 2017 |
Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α
Z Song, AM Xiaoli, Q Zhang, Y Zhang, ES Yang, S Wang, R Chang, ZD Zhang, G Yang, R Strich, JE Pessin, F Yang |
The Journal of biological chemistry | 2017 |
Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning
M Patil, BK Sharma, S Elattar, J Chang, S Kapil, J Yuan, A Satyanarayana |
Diabetes | 2017 |
Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57BL/6 mice
LF Gonçalves, TQ Machado, C Castro-Pinheiro, NG de Souza, KJ Oliveira, C Fernandes-Santos |
International Journal of Experimental Pathology | 2017 |
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming
A Guilherme, DJ Pedersen, E Henchey, FS Henriques, LV Danai, Y Shen, B Yenilmez, DY Jung, JK Kim, IJ Lodhi, CF Semenkovich, MP Czech |
Molecular Metabolism | 2017 |
Cinnamon induces browning in subcutaneous adipocytes
HY Kwan, J Wu, T Su, XJ Chao, B Liu, X Fu, CL Chan, RH Lau, AK Tse, QB Han, WF Fong, Z Yu |
Scientific Reports | 2017 |
Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity
C Jiang, MA Cano-Vega, F Yue, L Kuang, N Narayanan, G Uzunalli, MP Merkel, S Kuang, M Deng |
Molecular Therapy | 2017 |
Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
L Huang, D Pan, Q Chen, LJ Zhu, J Ou, M Wabitsch, YX Wang |
Nature Communications | 2017 |
Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat
LH Chen, YW Chien, CT Liang, CH Chan, MH Fan, HY Huang |
Food & Nutrition Research | 2017 |
Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA
M Lundh, K Plucinska, MS Isidor, PS Petersen, B Emanuelli |
Molecular Metabolism | 2017 |
Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice
K Weitkunat, C Stuhlmann, A Postel, S Rumberger, M Fankhänel, A Woting, KJ Petzke, S Gohlke, TJ Schulz, M Blaut, S Klaus, S Schumann |
Scientific Reports | 2017 |
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
YE Kang, S Choung, JH Lee, HJ Kim, BJ Ku |
Endocrinology and Metabolism | 2017 |
Fifty shades of white: Understanding heterogeneity in white adipose stem cells
L Cleal, T Aldea, YY Chau |
Adipocyte | 2017 |
Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression
A Fukunaka, T Fukada, J Bhin, L Suzuki, T Tsuzuki, Y Takamine, BH Bin, T Yoshihara, N Ichinoseki-Sekine, H Naito, T Miyatsuka, S Takamiya, T Sasaki, T Inagaki, T Kitamura, S Kajimura, H Watada, Y Fujitani, GS Barsh |
PLoS genetics | 2017 |
Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes
CR Dechandt, FH Zuccolotto-dos-Reis, BG Teodoro, AM Fernandes, MN Eberlin, IC Kettelhut, C Curti, LC Alberici |
Journal of Bioenergetics and Biomembranes | 2017 |
Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity
Y Chen, X Zeng, X Huang, S Serag, CJ Woolf, BM Spiegelman |
Cell | 2017 |
Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure: A Narrative Review
L Mele, G Bidault, P Mena, A Crozier, F Brighenti, A Vidal-Puig, DD Rio |
Advances in nutrition (Bethesda, Md.) | 2017 |
PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing
M Kissig, J Ishibashi, MJ Harms, HW Lim, RR Stine, KJ Won, P Seale |
The EMBO Journal | 2017 |
Epigenetic Regulation of the Thermogenic Adipose Program
A Sambeat, O Gulyaeva, J Dempersmier, HS Sul |
Trends in Endocrinology & Metabolism | 2017 |
Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates diet-induced obesity
C Jiang, M Zhai, D Yan, D Li, C Li, Y Zhang, L Xiao, D Xiong, Q Deng, W Sun |
Oncotarget | 2017 |
Brown Adipose Tissue: an Update on Recent Findings
KL Marlatt, E Ravussin |
Current Obesity Reports | 2017 |
UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
K Ikeda, Q Kang, T Yoneshiro, JP Camporez, H Maki, M Homma, K Shinoda, Y Chen, X Lu, P Maretich, K Tajima, KM Ajuwon, T Soga, S Kajimura |
Nature Medicine | 2017 |
MicroRNA-27b Depletion Enhances Endotrophic and Intravascular Lipid Accumulation and Induces Adipocyte Hyperplasia in Zebrafish
CC Hsu, CY Lai, CY Lin, KY Yeh, G Her |
International journal of molecular sciences | 2017 |
Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice
L Gan, Z Liu, F Feng, T Wu, D Luo, C Hu, C Sun |
International Journal of Obesity | 2017 |
Fattening the role of Ca2+ cycling in adaptive thermogenesis.
Gamu D, Tupling AR |
Nature Medicine | 2017 |
Thermogenic Profiling using Magnetic Resonance Imaging of Dermal and Other Adipose Tissues
Ildiko Kasza, Diego Hernando, Alejandro Roldán-Alzate, Caroline Alexander, Scott Reeder |
JCI Insight | 2016 |
Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice
GY Liu, J Liu, YL Wang, Y Liu, Y Shao, Y Han, YR Qin, FJ Xiao, PF Li, LJ Zhao, EY Gu, SY Chen, LH Gao, CT Wu, XW Hu, HF Duan |
Stem Cells Translational Medicine | 2016 |
Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome
MV de Pette, SJ Tunster, GI McNamara, T Shelkovnikova, S Millership, L Benson, S Peirson, M Christian, A Vidal-Puig, RM John, MS Bartolomei |
PLoS genetics | 2016 |
A novel thermoregulatory role for PDE10A in mouse and human adipocytes
MK Hankir, M Kranz, T Gnad, J Weiner, S Wagner, W DeutherConrad, F Bronisch, K Steinhoff, J Luthardt, N Klöting, S Hesse, JP Seibyl, O Sabri, JT Heiker, M Blüher, A Pfeifer, P Brust, WK Fenske |
EMBO Molecular Medicine | 2016 |
Heterogeneity of white adipose tissue: molecular basis and clinical implications
KH Kwok, KS Lam, A Xu |
Experimental & molecular medicine | 2016 |
Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis
EH Koh, Y Chen, DA Bader, MP Hamilton, B He, B York, S Kajimura, SE McGuire, SM Hartig |
The Journal of biological chemistry | 2016 |
Brain Regulation of Energy Metabolism
E Roh, MS Kim |
Endocrinology and Metabolism | 2016 |
Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis
N Li, Q Yang, RG Walker, TB Thompson, M Du, BD Rodgers |
Endocrinology | 2016 |
Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue
CM Tran, S Mukherjee, L Ye, DW Frederick, M Kissig, JG Davis, DW Lamming, P Seale, JA Baur |
Diabetes | 2016 |
Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases
A Ferrari, E Fiorino, R Longo, S Barilla, N Mitro, G Cermenati, M Giudici, D Caruso, A Mai, U Guerrini, ED Fabiani, M Crestani |
International Journal of Obesity | 2016 |
Brown adipose tissue: The heat is on the heart
R Thoonen, AG Hindle, M Scherrer-Crosbie |
American journal of physiology. Heart and circulatory physiology | 2016 |
Adipose tissue in control of metabolism
L Luo, M Liu |
Journal of Endocrinology | 2016 |
Cell biology of fat storage
P Cohen, BM Spiegelman |
Molecular biology of the cell | 2016 |
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders
SS Choe, JY Huh, IJ Hwang, JI Kim, JB Kim |
Frontiers in Endocrinology | 2016 |
Organization of nuclear architecture during adipocyte differentiation
NL Charó, MI Ceschan, NM Galigniana, J Toneatto, G Piwien-Pilipuk |
Nucleus | 2016 |
Convertible visceral fat as a therapeutic target to curb obesity
A Giordano, A Frontini, S Cinti |
Nature Reviews Drug Discovery | 2016 |
Does bariatric surgery improve adipose tissue function?: Bariatric surgery and adipose tissue
H Frikke-Schmidt, RW O'Rourke, CN Lumeng, DA Sandoval, RJ Seeley |
Obesity Reviews | 2016 |
Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism
E Roh, DK Song, MS Kim |
Experimental & molecular medicine | 2016 |
White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways
V Barquissau, D Beuzelin, DF Pisani, GE Beranger, A Mairal, A Montagner, B Roussel, G Tavernier, MA Marques, C Moro, H Guillou, EZ Amri, D Langin |
Molecular Metabolism | 2016 |
EBF2 promotes the recruitment of beige adipocytes in white adipose tissue
RR Stine, SN Shapira, HW Lim, J Ishibashi, M Harms, KJ Won, P Seale |
Molecular Metabolism | 2016 |
Transcriptional and epigenetic control of brown and beige adipose cell fate and function
T Inagaki, J Sakai, S Kajimura |
Nature Reviews Molecular Cell Biology | 2016 |
Influencing Factors of Thermogenic Adipose Tissue Activity
G Zhang, Q Sun, C Liu |
Frontiers in physiology | 2016 |
GQ-16, a TZD-Derived Partial PPARγ Agonist, Induces the Expression of Thermogenesis-Related Genes in Brown Fat and Visceral White Fat and Decreases Visceral Adiposity in Obese and Hyperglycemic Mice
MS Coelho, CL de Lima, C Royer, JB Silva, FC Oliveira, CG Christ, SA Pereira, SN Bao, MC Lima, MG Pitta, IR Pitta, FA Neves, AA Amato, M Makishima |
PloS one | 2016 |
Inter-organ regulation of adipose tissue browning
S Wang, X Yang |
Cellular and Molecular Life Sciences | 2016 |
miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity
AD Gaudet, LK Fonken, LV Gushchina, TG Aubrecht, SK Maurya, M Periasamy, RJ Nelson, PG Popovich |
Scientific Reports | 2016 |
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro
E Zhu, Y Yang, J Zhang, Y Li, C Li, L Chen, B Sun |
Oncotarget | 2016 |
Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16
H Ding, S Zheng, D Garcia-Ruiz, D Hou, Z Wei, Z Liao, L Li, Y Zhang, X Han, K Zen, CY Zhang, J Li, X Jiang |
Nature Communications | 2016 |
PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity
B Zhou, J Wang, SY Lee, J Xiong, N Bhanu, Q Guo, P Ma, Y Sun, RC Rao, BA Garcia, JL Hess, Y Dou |
Molecular Cell | 2016 |
Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue
UD Wankhade, M Shen, H Yadav, KM Thakali |
BioMed Research International | 2016 |
Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance
S Altshuler-Keylin, K Shinoda, Y Hasegawa, K Ikeda, H Hong, Q Kang, Y Yang, RM Perera, J Debnath, S Kajimura |
Cell Metabolism | 2016 |
Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice
A Ejaz, L Martinez-Guino, AB Goldfine, F Ribas-Aulinas, VD Nigris, S Ribó, A Gonzalez-Franquesa, PM Garcia-Roves, E Li, JM Dreyfuss, W Gall, JK Kim, T Bottiglieri, F Villarroya, RE Gerszten, ME Patti, C Lerin |
Diabetes | 2016 |
miRNA regulation of white and brown adipose tissue differentiation and function
NL Price, C Fernández-Hernando |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2016 |
Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity
Y Chen, JJ Buyel, MJ Hanssen, F Siegel, R Pan, J Naumann, M Schell, A der Lans, C Schlein, H Froehlich, J Heeren, KA Virtanen, WM Lichtenbelt, A Pfeifer |
Nature Communications | 2016 |
Control of brown and beige fat development
W Wang, P Seale |
Nature Reviews Molecular Cell Biology | 2016 |
Artepillin C, a Typical Brazilian Propolis-Derived Component, Induces Brown-Like Adipocyte Formation in C3H10T1/2 Cells, Primary Inguinal White Adipose Tissue-Derived Adipocytes, and Mice
S Nishikawa, H Aoyama, M Kamiya, J Higuchi, A Kato, M Soga, T Kawai, K Yoshimura, S Kumazawa, T Tsuda, H Xu |
PloS one | 2016 |
A novel combined glucocorticoid-mineralocorticoid receptor selective modulator markedly prevents weight gain and fat mass expansion in mice fed a high-fat diet
C Mammi, V Marzolla, A Armani, A Feraco, A Antelmi, E Maslak, S Chlopicki, F Cinti, H Hunt, A Fabbri, M Caprio |
International Journal of Obesity | 2016 |
A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis
K Ohyama, Y Nogusa, K Shinoda, K Suzuki, M Bannai, S Kajimura |
Diabetes | 2016 |
The critical period for brown adipocyte development: Genetic and environmental influences: Brown Adipocyte Development
A Chabowska-Kita, LP Kozak |
Obesity | 2016 |
Genetic backgrounds determine brown remodeling of white fat in rodents
G Ferrannini, M Namwanje, B Fang, M Damle, D Li, Q Liu, MA Lazar, L Qiang |
Molecular Metabolism | 2016 |
ASK1 signalling regulates brown and beige adipocyte function
K Hattori, I Naguro, K Okabe, T Funatsu, S Furutani, K Takeda, H Ichijo |
Nature Communications | 2016 |
Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans
A Gavaldà-Navarro, JM Moreno-Navarrete, T Quesada-López, M Cairó, M Giralt, JM Fernández-Real, F Villarroya |
Diabetologia | 2016 |
Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice
S Hanatani, H Motoshima, Y Takaki, S Kawasaki, M Igata, T Matsumura, T Kondo, T Senokuchi, N Ishii, J Kawashima, D Kukidome, S Shimoda, T Nishikawa, E Araki |
Journal of Clinical Biochemistry and Nutrition | 2016 |
Intermedin/adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice
H Zhang, SY Zhang, C Jiang, Y Li, G Xu, MJ Xu, X Wang |
International Journal of Obesity | 2016 |
The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria
JZ Long, KJ Svensson, LA Bateman, H Lin, T Kamenecka, IA Lokurkar, J Lou, RR Rao, MR Chang, MP Jedrychowski, JA Paulo, SP Gygi, PR Griffin, DK Nomura, BM Spiegelman |
Cell | 2016 |
Cannabidiol promotes browning in 3T3-L1 adipocytes
HA Parray, JW Yun |
Molecular and Cellular Biochemistry | 2016 |
Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice
TN Bukong, A Iracheta-Vellve, B Gyongyosi, A Ambade, D Catalano, K Kodys, G Szabo |
Alcoholism Clinical and Experimental Research | 2016 |
Marrow Adipose Tissue: Trimming the Fat
EL Scheller, WP Cawthorn, AA Burr, MC Horowitz, OA MacDougald |
Trends in Endocrinology & Metabolism | 2016 |
Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders
SH Kim, J Plutzky |
Diabetes & Metabolism Journal | 2016 |
Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture
X Qin, HG Park, JY Zhang, P Lawrence, G Liu, N Subramanian, KS Kothapalli, JT Brenna |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2016 |
Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
T Shan, Y Xiong, P Zhang, Z Li, Q Jiang, P Bi, F Yue, G Yang, Y Wang, X Liu, S Kuang |
Nature Communications | 2016 |
Browning and Graying: Novel Transcriptional Regulators of Brown and Beige Fat Tissues and Aging
E Mueller |
Frontiers in Endocrinology | 2016 |
ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs
MH Lee, AG Goralczyk, R Kriszt, XM Ang, C Badowski, Y Li, SA Summers, SA Toh, MS Yassin, A Shabbir, A Sheppard, M Raghunath |
Scientific Reports | 2016 |
Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals
Y Zhu, Y Gao, C Tao, M Shao, S Zhao, W Huang, T Yao, JA Johnson, T Liu, AM Cypess, O Gupta, WL Holland, RK Gupta, DC Spray, HB Tanowitz, L Cao, MD Lynes, YH Tseng, JK Elmquist, KW Williams, HV Lin, PE Scherer |
Cell Metabolism | 2016 |
Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program
M Shao, J Ishibashi, CM Kusminski, QA Wang, C Hepler, L Vishvanath, KA MacPherson, SB Spurgin, K Sun, WL Holland, P Seale, RK Gupta |
Cell Metabolism | 2016 |
FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle
BM Varela-Rodríguez, L Pena-Bello, P Juiz-Valiña, B Vidal-Bretal, F Cordido, S Sangiao-Alvarellos |
Scientific Reports | 2016 |
Monoterpene phenolic compound thymol promotes browning of 3T3-L1 adipocytes
JH Choi, SW Kim, R Yu, JW Yun |
European Journal of Nutrition | 2016 |
The Mechanism by Which Safflower Yellow Decreases Body Fat Mass and Improves Insulin Sensitivity in HFD-Induced Obese Mice
H Zhu, X Wang, H Pan, Y Dai, N Li, L Wang, H Yang, F Gong |
Frontiers in pharmacology | 2016 |
A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function
KJ Svensson, JZ Long, MP Jedrychowski, P Cohen, JC Lo, S Serag, S Kir, K Shinoda, JA Tartaglia, RR Rao, A Chédotal, S Kajimura, SP Gygi, BM Spiegelman |
Cell Metabolism | 2016 |
Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate
M Sahuri-Arisoylu, LP Brody, JR Parkinson, H Parkes, N Navaratnam, AD Miller, EL Thomas, G Frost, JD Bell |
International Journal of Obesity | 2016 |
Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation
X Zeng, MP Jedrychowski, Y Chen, S Serag, GG Lavery, SP Gygi, BM Spiegelman |
Genes & development | 2016 |
Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss
A Nakhuda, AR Josse, V Gburcik, H Crossland, F Raymond, S Metairon, L Good, PJ Atherton, SM Phillips, JA Timmons |
The American journal of clinical nutrition | 2016 |
Coordinate mobilization and burning of lipid stores . Focus on “Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health”
MJ Brady |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2016 |
Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα
M Yan, É Audet-Walsh, S Manteghi, CR Dufour, B Walker, M Baba, J St-Pierre, V Giguère, A Pause |
Genes & development | 2016 |
Editorial: Unlocking Therapeutic Potential of Brown Fat
RS Ahima |
Molecular Endocrinology | 2016 |
Circulating Adipocyte Fatty Acid Binding Protein (FABP4) Levels Are Associated with Irisin in the Middle-Aged General Chinese Population
S Zhang, L Yang, P Chen, H Jin, X Xie, M Yang, T Gao, C Hu, X Yu, ML Hribal |
PloS one | 2016 |
The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment
C Hepler, RK Gupta |
Molecular and Cellular Endocrinology | 2016 |
Distinct functions of PPARγ isoforms in regulating adipocyte plasticity
D Li, F Zhang, X Zhang, C Xue, M Namwanje, L Fan, MP Reilly, F Hu, L Qiang |
Biochemical and Biophysical Research Communications | 2016 |
Metabolic programming of a beige adipocyte phenotype by genistein
SA Aziz, LA Wakeling, S Miwa, G Alberdi, JE Hesketh, D Ford |
Molecular Nutrition & Food Research | 2016 |
Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis
R Brunmeir, J Wu, X Peng, SY Kim, SG Julien, Q Zhang, W Xie, F Xu, C Wolfrum |
PLoS genetics | 2016 |
Clozapine modifies the differentiation program of human adipocytes inducing browning
E Kristóf, QM Doan-Xuan, AK Sárvári, Á Klusóczki, P Fischer-Posovszky, M Wabitsch, Z Bacso, P Bai, Z Balajthy, L Fésüs |
Translational Psychiatry | 2016 |
Original Research: Hydroxytyrosol, an ingredient of olive oil, reduces triglyceride accumulation and promotes lipolysis in human primary visceral adipocytes during differentiation
B Stefanon, M Colitti |
Experimental biology and medicine (Maywood, N.J.) | 2016 |
Thermoneutrality decreases thermogenic program and promotes adiposity in high-fat diet-fed mice
X Cui, NL Nguyen, E Zarebidaki, Q Cao, F Li, L Zha, T Bartness, H Shi, B Xue |
Physiological Reports | 2016 |
Direct lentivirus injection for fast and efficient gene transfer into brown and beige adipose tissue
A Balkow, LS Hoffmann, K Klepac, A Glöde, T Gnad, K Zimmermann, A Pfeifer |
Journal of Biological Methods | 2016 |
AT1 receptor antagonist induces thermogenic beige adipocytes in the inguinal white adipose tissue of obese mice.
Graus-Nunes F, Rachid TL, de Oliveira Santos F, Barbosa-da-Silva S, Souza-Mello V |
Endocrine | 2016 |
Brown and Beige Fat in Humans: Thermogenic adipocytes that control energy and glucose homeostasis
Labros Siddossis, Shingo Kajimura |
Journal of Clinical Investigation | 2015 |
Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance
AL Poher, J Altirriba, C Veyrat-Durebex, FÃ Rohner-Jeanrenaud |
Frontiers in physiology | 2015 |
Transcriptional control and hormonal response of thermogenic fat
MP Emont, H Yu, J Wu |
Journal of Endocrinology | 2015 |
Formation and activation of thermogenic fat
J Wu, H Jun, JR McDermott |
Trends in Genetics | 2015 |
The miRNA Interactome in Metabolic Homeostasis
SM Hartig, MP Hamilton, DA Bader, SE McGuire |
Trends in Endocrinology & Metabolism | 2015 |
Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat
GT Dodd, S Decherf, K Loh, SE Simonds, F Wiede, E Balland, TL Merry, H Münzberg, ZY Zhang, BB Kahn, BG Neel, KK Bence, ZB Andrews, MA Cowley, T Tiganis |
Cell | 2015 |
Adipose VEGF links the white-to-brown fat switch with environmental, genetic, and pharmacological stimuli in male mice
MJ During, X Liu, W Huang, D Magee, A Slater, T McMurphy, C Wang, L Cao |
Endocrinology | 2015 |
Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation
P Seale |
Diabetes | 2015 |
Ubc9 impairs activation of the brown fat energy metabolism program in human white adipocytes
SM Hartig, DA Bader, KV Abadie, M Motamed, MP Hamilton, W Long, B York, M Mueller, M Wagner, M Trauner, L Chan, M Bajaj, DD Moore, MA Mancini, SE McGuire |
Molecular Endocrinology | 2015 |
Hydrogel-based engineering of beige adipose tissue
MK Vaicik, M Morse, A Blagajcevic, J Rios, JC Larson, F Yang, RN Cohen, G Papavasiliou, EM Brey |
Journal of Materials Chemistry B | 2015 |
Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice
N Douris, DM Stevanovic, M Fisher, TI Cisu, MJ Chee, NL Nguyen, E Zarebidaki, AC Adams, A Kharitonenkov, JS Flier, TJ Bartness, E Maratos-Flier |
Endocrinology | 2015 |
A metabolomic study of adipose tissue in mice with a disruption of the circadian system
C Castro, W Briggs, GK Paschos, GA FitzGerald, JL Griffin |
Molecular BioSystems | 2015 |
Adipose Tissue-Residing Progenitors (Adipocyte Lineage Progenitors and Adipose-Derived Stem Cells (ADSC))
R Berry, MS Rodeheffer, CJ Rosen, MC Horowitz |
Current Molecular Biology Reports | 2015 |
The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation
L Zha, F Li, R Wu, L Artinian, V Rehder, L Yu, H Liang, B Xue, H Shi |
The Journal of biological chemistry | 2015 |
Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations
KI Stanford, RJ Middelbeek, LJ Goodyear |
Diabetes | 2015 |
Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure
K Shinoda, K Ohyama, Y Hasegawa, HY Chang, M Ogura, A Sato, H Hong, T Hosono, LZ Sharp, DW Scheel, M Graham, Y Ishihama, S Kajimura |
Cell Metabolism | 2015 |
PTHrp comes full circle in cancer biology
AR Guntur, CR Doucette, CJ Rosen |
BoneKEy Reports | 2015 |
A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis
KI Stanford, RJ Middelbeek, KL Townsend, MY Lee, H Takahashi, K So, KM Hitchcox, KR Markan, K Hellbach, MF Hirshman, YH Tseng, LJ Goodyear |
Diabetes | 2015 |
Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers
HY Kwan, X Niu, W Dai, T Tong, X Chao, T Su, CL Chan, KC Lee, X Fu, H Yi, H Yu, T Li, AK Tse, WF Fong, SY Pan, A Lu, ZL Yu |
Scientific Reports | 2015 |
Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat
J Dempersmier, A Sambeat, O Gulyaeva, SM Paul, CS Hudak, HF Raposo, HY Kwan, C Kang, RH Wong, HS Sul |
Molecular Cell | 2015 |
Functions of Prdm16 in thermogenic fat cells
J Ishibashi, P Seale |
Temperature | 2015 |
Activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning
MD Neinast, AP Frank, JF Zechner, Q Li, L Vishvanath, BF Palmer, V Aguirre, RK Gupta, DJ Clegg |
Molecular Metabolism | 2015 |
Wt1, the mesothelium and the origins and heterogeneity of visceral fat progenitors
YY Chau, N Hastie |
Adipocyte | 2015 |
Visceral White Adipose Tissue is Susceptible to Alcohol-Induced Lipodystrophy in Rats: Role of Acetaldehyde
W Zhang, W Zhong, X Sun, Q Sun, X Tan, Q Li, X Sun, Z Zhou |
Alcoholism Clinical and Experimental Research | 2015 |
PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1
S Iida, W Chen, T Nakadai, Y Ohkuma, RG Roeder |
Genes & development | 2015 |
PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program
MJ Harms, HW Lim, Y Ho, SN Shapira, J Ishibashi, S Rajakumari, DJ Steger, MA Lazar, KJ Won, P Seale |
Genes & development | 2015 |
Regulation of systemic energy homeostasis by serotonin in adipose tissues
CM Oh, J Namkung, Y Go, KE Shong, K Kim, H Kim, BY Park, HW Lee, YH Jeon, J Song, M Shong, VK Yadav, G Karsenty, S Kajimura, IK Lee, S Park, H Kim |
Nature Communications | 2015 |
De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development
JR Alvarez-Dominguez, Z Bai, D Xu, B Yuan, KA Lo, MJ Yoon, YC Lim, M Knoll, N Slavov, S Chen, P Chen, HF Lodish, L Sun |
Cell Metabolism | 2015 |
Brown Adipose Tissue Activation Is Inversely Related to Central Obesity and Metabolic Parameters in Adult Human
Q Wang, M Zhang, M Xu, W Gu, Y Xi, L Qi, B Li, W Wang, Q Sun |
PloS one | 2015 |
miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140
F Hu, M Wang, T Xiao, B Yin, L He, W Meng, M Dong, F Liu |
Diabetes | 2015 |
Two key temporally distinguishable molecular and cellular components of white adipose tissue browning during cold acclimation: Browning of white adipose tissue during cold acclimation
A Jankovic, I Golic, M Markelic, A Stancic, V Otasevic, B Buzadzic, A Korac, B Korac |
The Journal of Physiology | 2015 |
Can Brown Fat Win the Battle Against White Fat?: BAT VERSUS WAT
S Elattar, A Satyanarayana |
Journal of Cellular Physiology | 2015 |
Brown and Beige Fat: Molecular Parts of a Thermogenic Machine: Figure 1
P Cohen, BM Spiegelman |
Diabetes | 2015 |
The intake of high-fat diets induces the acquisition of brown adipocyte gene expression features in white adipose tissue
E García-Ruiz, B Reynés, R Díaz-Rúa, E Ceresi, P Oliver, A Palou |
International Journal of Obesity | 2015 |
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes
A Than, HL He, SH Chua, D Xu, L Sun, MK Leow, P Chen |
The Journal of biological chemistry | 2015 |
Brown adipose tissue and bone
ME Lidell, S Enerbäck |
International Journal of Obesity Supplements | 2015 |
Fetal endocrine and metabolic adaptations to hypoxia: the role of the hypothalamic-pituitary-adrenal axis: Fig. 1
EA Newby, DA Myers, CA Ducsay |
American journal of physiology. Endocrinology and metabolism | 2015 |
Brown and Beige Fat: Physiological Roles beyond Heat Generation
S Kajimura, BM Spiegelman, P Seale |
Cell Metabolism | 2015 |
Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice
P Pazos, L Lima, S Tovar, D González-Touceda, C Diéguez, MC García |
Scientific Reports | 2015 |
Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity
XR Peng, P Gennemark, G OMahony, S Bartesaghi |
Frontiers in Endocrinology | 2015 |
Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity
F Verdeguer, MS Soustek, M Hatting, SM Blättler, D McDonald, JJ Barrow, P Puigserver |
Molecular and cellular biology | 2015 |
Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency Promotes Differentiation of Satellite Cells to Brown Adipocytes in a Cholesterol-Dependent Manner
D Nesan, G Tavallaee, D Koh, A Bashiri, R Abdin, DS Ng |
The Journal of biological chemistry | 2015 |
Dermal white adipose tissue: a new component of the thermogenic response
CM Alexander, I Kasza, CL Yen, SB Reeder, D Hernando, RL Gallo, CA Jahoda, V Horsley, OA MacDougald |
Journal of lipid research | 2015 |
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
M Claussnitzer, SN Dankel, KH Kim, G Quon, W Meuleman, C Haugen, V Glunk, IS Sousa, JL Beaudry, V Puviindran, NA Abdennur, J Liu, PA Svensson, YH Hsu, DJ Drucker, G Mellgren, CC Hui, H Hauner, M Kellis |
New England Journal of Medicine | 2015 |
Ghrelin receptor controls obesity by fat burning
Sun Y |
Oncotarget | 2015 |
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms
B Lu, Y Diz-Chaves, D Markovic, A Contarino, L Penicaud, F Fanelli, S Clark, H Lehnert, D Cota, DK Grammatopoulos, A Tabarin |
International Journal of Obesity | 2014 |
Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans
P Lee, S Smith, J Linderman, AB Courville, RJ Brychta, W Dieckmann, CD Werner, KY Chen, FS Celi |
Diabetes | 2014 |
Syndecan-1 is required to maintain intradermal fat and prevent cold stress
I Kasza, Y Suh, D Wollny, RJ Clark, A Roopra, RJ Colman, OA MacDougald, TA Shedd, DW Nelson, MI Yen, CL Yen, CM Alexander |
PLoS genetics | 2014 |
Erythropoietin, a Novel Versatile Player Regulating Energy Metabolism beyond the Erythroid System
L Wang, L Di, CT Noguchi |
International journal of biological sciences | 2014 |
p53 induces skin aging by depleting Blimp1+ sebaceous gland cells
J Kim, M Nakasaki, D Todorova, B Lake, CY Yuan, C Jamora, Y Xu |
Cell Death and Disease | 2014 |
The brain and brown fat
C Contreras, F Gonzalez, J Fernø, C Diéguez, K Rahmouni, R Nogueiras, M López |
Annals of Medicine | 2014 |
AMPK is Involved in Mediation of Erythropoietin Influence on Metabolic Activity and Reactive Oxygen Species Production in White Adipocytes
L Wang, L Di, CT Noguchi |
The International Journal of Biochemistry & Cell Biology | 2014 |
Prenatal Metformin Exposure in a Maternal High Fat Diet Mouse Model Alters the Transcriptome and Modifies the Metabolic Responses of the Offspring
H Salomäki, M Heinäniemi, LH Vähätalo, L Ailanen, K Eerola, ST Ruohonen, U Pesonen, M Koulu, M Claret |
PloS one | 2014 |
Regulation of brown adipocyte metabolism by myostatin/follistatin signaling
R Singh, M Braga, S Pervin |
Frontiers in Cell and Developmental Biology | 2014 |
Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
MJ Harms, J Ishibashi, W Wang, HW Lim, S Goyama, T Sato, M Kurokawa, KJ Won, P Seale |
Cell Metabolism | 2014 |
Dietary Fucoxanthin Increases Metabolic Rate and Upregulated mRNA Expressions of the PGC-1alpha Network, Mitochondrial Biogenesis and Fusion Genes in White Adipose Tissues of Mice
MT Wu, HN Chou, C Huang |
Marine drugs | 2014 |
Prostaglandin E2 signals white-to-brown adipogenic differentiation
V García-Alonso, J Clària |
Adipocyte | 2014 |
Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch
P Cohen, JD Levy, Y Zhang, A Frontini, DP Kolodin, KJ Svensson, JC Lo, X Zeng, L Ye, MJ Khandekar, J Wu, SC Gunawardana, AS Banks, JP Camporez, MJ Jurczak, S Kajimura, DW Piston, D Mathis, S Cinti, GI Shulman, P Seale, BM Spiegelman |
Cell | 2014 |
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity
P Bi, T Shan, W Liu, F Yue, X Yang, XR Liang, J Wang, J Li, N Carlesso, X Liu, S Kuang |
Nature Medicine | 2014 |
Reducing RIP140 Expression in Macrophage Alters ATM Infiltration, Facilitates White Adipose Tissue Browning, and Prevents High-Fat Diet-Induced Insulin Resistance
PS Liu, YW Lin, B Lee, SK McCrady-Spitzer, JA Levine, LN Wei |
Diabetes | 2014 |
The Role of SIRT1 in Diabetic Kidney Disease
R Yacoub, K Lee, JC He |
Frontiers in Endocrinology | 2014 |
RGC32 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice
XB Cui, JN Luan, J Ye, SY Chen |
Journal of Endocrinology | 2014 |
Partial Agonist, Telmisartan, Maintains PPARγ Serine 112 Phosphorylation, and Does Not Affect Osteoblast Differentiation and Bone Mass
V Kolli, LA Stechschulte, AR Dowling, S Rahman, PJ Czernik, B Lecka-Czernik |
PloS one | 2014 |
Comprehensive Physiology
SF Morrison, CJ Madden |
Comprehensive Physiology | 2014 |
Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers
A Loft, I Forss, MS Siersbæk, SF Schmidt, AS Larsen, JG Madsen, DF Pisani, R Nielsen, MM Aagaard, A Mathison, MJ Neville, R Urrutia, F Karpe, EZ Amri, S Mandrup |
Genes & development | 2014 |
Chronic Glucocorticoid Exposure-Induced Epididymal Adiposity Is Associated with Mitochondrial Dysfunction in White Adipose Tissue of Male C57BL/6J Mice
J Yu, B Yu, J He, P Zheng, X Mao, G Han, D Chen, M Alemany |
PloS one | 2014 |
Advances in Fetal and Neonatal Physiology
L Zhang, CA Ducsay |
2014 | |
Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat
J Suárez, P Rivera, S Arrabal, A Crespillo, A Serrano, E Baixeras, FJ Pavón, M Cifuentes, R Nogueiras, J Ballesteros, C Dieguez, FR de Fonseca |
Disease models & mechanisms | 2014 |
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
HB Ruan, MO Dietrich, ZW Liu, MR Zimmer, MD Li, JP Singh, K Zhang, R Yin, J Wu, TL Horvath, X Yang |
Cell | 2014 |
Benefits of healthy adipose tissue in the treatment of diabetes
SC Gunawardana |
World journal of diabetes | 2014 |
KSRP Ablation Enhances Brown Fat Gene Program in White Adipose Tissue Through Reduced miR-150 Expression
CF Chou, YY Lin, HK Wang, X Zhu, M Giovarelli, P Briata, R Gherzi, WT Garvey, CY Chen |
Diabetes | 2014 |
Weighing in on Adipocyte Precursors
R Berry, E Jeffery, MS Rodeheffer |
Cell Metabolism | 2014 |
Perivascular Adipose Tissue in Vascular Function and Disease: A Review of Current Research and Animal Models
NK Brown, Z Zhou, J Zhang, R Zeng, J Wu, DT Eitzman, YE Chen, L Chang |
Arteriosclerosis, thrombosis, and vascular biology | 2014 |
The different shades of fat
V Peirce, S Carobbio, A Vidal-Puig |
Nature | 2014 |
MicroRNA-378 controls classical brown fat expansion to counteract obesity
D Pan, C Mao, B Quattrochi, RH Friedline, LJ Zhu, DY Jung, JK Kim, B Lewis, YX Wang |
Nature Communications | 2014 |
Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis
MA Lim, KK Bence, I Sandesara, P Andreux, J Auwerx, J Ishibashi, P Seale, RG Kalb |
Human Molecular Genetics | 2014 |
Recent advance in brown adipose physiology and its therapeutic potential
YH Lee, YS Jung, D Choi |
Experimental & molecular medicine | 2014 |
β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
LD Roberts, P Boström, JF O’Sullivan, RT Schinzel, GD Lewis, A Dejam, YK Lee, MJ Palma, S Calhoun, A Georgiadi, MH Chen, VS Ramachandran, MG Larson, C Bouchard, T Rankinen, AL Souza, CB Clish, TJ Wang, JL Estall, AA Soukas, CA Cowan, BM Spiegelman, RE Gerszten |
Cell Metabolism | 2014 |
A Smooth Muscle-Like Origin for Beige Adipocytes
JZ Long, KJ Svensson, L Tsai, X Zeng, HC Roh, X Kong, RR Rao, J Lou, I Lokurkar, W Baur, JJ Castellot, ED Rosen, BM Spiegelman |
Cell Metabolism | 2014 |
Olive Leaf Extract Attenuates Obesity in High-Fat Diet-Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis
Y Shen, SJ Song, N Keum, T Park |
Evidence-Based Complementary and Alternative Medicine | 2014 |
Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat
Y Qiu, KD Nguyen, JI Odegaard, X Cui, X Tian, RM Locksley, RD Palmiter, A Chawla |
Cell | 2014 |
Methods in Enzymology
R Berry, CD Church, MT Gericke, E Jeffery, L Colman, MS Rodeheffer |
Methods in enzymology | 2014 |
Large-scale analysis reveals a functional single-nucleotide polymorphism in the 5′-flanking region of PRDM16 gene associated with lean body mass
T Urano, M Shiraki, N Sasaki, Y Ouchi, S Inoue |
Aging Cell | 2014 |
LSD1 promotes oxidative metabolism of white adipose tissue
D Duteil, E Metzger, D Willmann, P Karagianni, N Friedrichs, H Greschik, T Günther, R Buettner, I Talianidis, D Metzger, R Schüle |
Nature Communications | 2014 |
Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice
M Rosell, M Kaforou, A Frontini, A Okolo, YW Chan, E Nikolopoulou, S Millership, ME Fenech, D MacIntyre, JO Turner, JD Moore, E Blackburn, WJ Gullick, S Cinti, G Montana, MG Parker, M Christian |
American journal of physiology. Endocrinology and metabolism | 2014 |
Molecular heterogeneities of adipose depots - potential effects on adipose-muscle cross-talk in humans, mice and farm animals
K Komolka, E Albrecht, K Wimmers, JJ Michal, S Maak |
Journal of genomics | 2014 |
Molecular Aspects of Adipoepithelial Transdifferentiation in Mouse Mammary Gland: Adipoepithelial Transdifferentiation
A Prokesch, A Smorlesi, J Perugini, M Manieri, P Ciarmela, E Mondini, Z Trajanoski, K Kristiansen, A Giordano, JG Bogner-Strauss, S Cinti |
Stem Cells | 2014 |
MAGP1, the extracellular matrix, and metabolism
CS Craft |
Adipocyte | 2014 |
TAF7L modulates brown adipose tissue formation
H Zhou, B Wan, I Grubisic, T Kaplan, R Tjian, JT Kadonaga |
eLife | 2014 |
Inorganic Nitrate Promotes the Browning of White Adipose Tissue Through the Nitrate-Nitrite-Nitric Oxide Pathway
LD Roberts, T Ashmore, AO Kotwica, SA Murfitt, BO Fernandez, M Feelisch, AJ Murray, JL Griffin |
Diabetes | 2014 |
Ebf2 is a selective marker of brown and beige adipogenic precursor cells
W Wang, M Kissig, S Rajakumari, L Huang, H Lim, KJ Won, P Seale |
Proceedings of the National Academy of Sciences | 2014 |
The Great Roundleaf Bat (Hipposideros armiger) as a Good Model for Cold-Induced Browning of Intra-Abdominal White Adipose Tissue
Y Wang, T Zhu, S Ke, N Fang, DM Irwin, M Lei, J Zhang, H Shi, S Zhang, Z Wang, HB Tanowitz |
PloS one | 2014 |
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
JR Brestoff, BS Kim, SA Saenz, RR Stine, LA Monticelli, GF Sonnenberg, JJ Thome, DL Farber, K Lutfy, P Seale, D Artis |
Nature | 2014 |
Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development
AC Daquinag, C Tseng, A Salameh, Y Zhang, F Amaya-Manzanares, A Dadbin, F Florez, Y Xu, Q Tong, MG Kolonin |
Cell Death and Differentiation | 2014 |
Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue
X Kong, J Yu, J Bi, H Qi, W Di, L Wu, L Wang, J Zha, S Lv, F Zhang, Y Li, F Hu, F Liu, H Zhou, J Liu, G Ding |
Diabetes | 2014 |
Irisin ERKs the Fat
J Wu, BM Spiegelman |
Diabetes | 2014 |
Gene Delivery to Adipose Tissue Using Transcriptionally Targeted rAAV8 Vectors
S Uhrig-Schmidt, M Geiger, G Luippold, G Birk, D Mennerich, H Neubauer, D Grimm, C Wolfrum, S Kreuz, RJ Samulski |
PloS one | 2014 |
SRA Gene Knockout Protects against Diet-induced Obesity and Improves Glucose Tolerance
S Liu, L Sheng, H Miao, TL Saunders, OA MacDougald, RJ Koenig, B Xu |
The Journal of biological chemistry | 2014 |
Inducible brown adipocytes in subcutaneous inguinal white fat: the role of continuous sympathetic stimulation
GA Contreras, YH Lee, EP Mottillo, JG Granneman |
American journal of physiology. Endocrinology and metabolism | 2014 |
Subcutaneous Adipocytes Promote Melanoma Cell Growth by Activating the Akt Signaling Pathway: ROLE OF PALMITIC ACID
HY Kwan, X Fu, B Liu, X Chao, CL Chan, H Cao, T Su, AK Tse, WF Fong, ZL Yu |
The Journal of biological chemistry | 2014 |
MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function
T Fu, S Seok, S Choi, Z Huang, K Suino-Powell, HE Xu, B Kemper, JK Kemper |
Molecular and cellular biology | 2014 |
Acupuncture promotes white adipose tissue browning by inducing UCP1 expression on DIO mice
W Shen, Y Wang, SF Lu, H Hong, S Fu, S He, Q Li, J Yue, B Xu, BM Zhu |
BMC complementary and alternative medicine | 2014 |
Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic 3-adrenergic receptor activation
EP Mottillo, P Balasubramanian, YH Lee, C Weng, EE Kershaw, JG Granneman |
Journal of lipid research | 2014 |
Effects of Vitamin A Status on Expression of Ucp1 and Brown/Beige Adipocyte-Related Genes in White Adipose Tissues of Beef Cattle
KANAMORI Y, YAMADA T, ASANO H, KIDA R, QIAO Y, ABD ELDAIM MA, TOMONAGA S, MATSUI T, FUNABA M |
Journal of Veterinary Medical Science | 2014 |
11C-Meta-Hydroxyephedrine Pet/Ct Imaging Allows In Vivo Study Of Adaptive Thermogenesis And White-To-Brown Fat Conversion
C Quarta, F Lodi, R Mazza, FA Giannone, L Boschi, C Nanni, E Nisoli, S Boschi, R Pasquali, S Fanti, P Iozzo, U Pagotto |
Molecular Metabolism | 2013 |
Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton
S Rahman, Y Lu, PJ Czernik, CJ Rosen, S Enerback, B Lecka-Czernik |
Endocrinology | 2013 |
Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice
YS Lee, T Sasaki, M Kobayashi, O Kikuchi, HJ Kim, H Yokota-Hashimoto, M Shimpuku, VY Susanti, Y Ido-Kitamura, K Kimura, H Inoue, M Tanaka-Okamoto, H Ishizaki, J Miyoshi, S Ohya, Y Tanaka, S Kitajima, T Kitamura |
Diabetologia | 2013 |
Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs
CJ Villanueva, L Vergnes, J Wang, BG Drew, C Hong, Y Tu, Y Hu, X Peng, F Xu, E Saez, K Wroblewski, AL Hevener, K Reue, LG Fong, SG Young, P Tontonoz |
Cell Metabolism | 2013 |
Inhibition of in vitro and in vivo brown fat differentiation program by myostatin
M Braga, S Pervin, K Norris, S Bhasin, R Singh |
Obesity | 2013 |
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance
R Quintens, S Singh, K Lemaire, KD Bock, M Granvik, A Schraenen, IO Vroegrijk, V Costa, PV Noten, D Lambrechts, S Lehnert, LV Lommel, L Thorrez, GD Faudeur, JA Romijn, JM Shelton, L Scorrano, HR Lijnen, PJ Voshol, P Carmeliet, PP Mammen, F Schuit |
PloS one | 2013 |
Brown and beige fat: development, function and therapeutic potential
M Harms, P Seale |
Nature Medicine | 2013 |
Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues
T Shan, W Liu, S Kuang |
The FASEB Journal | 2013 |
Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor (PPAR ) in the Conversion of White-to-brown Adipocytes
V Garcia-Alonso, C Lopez-Vicario, E Titos, E Moran-Salvador, A Gonzalez-Periz, B Rius, M Parrizas, O Werz, V Arroyo, J Claria |
The Journal of biological chemistry | 2013 |
Adipose tissue plasticity from WAT to BAT and in between
YH Lee, EP Mottillo, JG Granneman |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 |
Adipose-derived stromal/stem cells
JM Gimble, BA Bunnell, T Frazier, B Rowan, F Shah, C Thomas-Porch, X Wu |
Organogenesis | 2013 |
Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes
T Sakamoto, N Takahashi, Y Sawaragi, S Naknukool, R Yu, T Goto, T Kawada |
American journal of physiology. Cell physiology | 2013 |
Distinct populations of adipogenic and myogenic Myf5-lineage progenitors in white adipose tissues
T Shan, X Liang, P Bi, P Zhang, W Liu, S Kuang |
Journal of lipid research | 2013 |
PPARγ: no SirT, no service
FW Quelle, CD Sigmund |
Circulation research | 2013 |
Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice
JS Teodoro, P Zouhar, P Flachs, K Bardova, P Janovska, AP Gomes, FV Duarte, AT Varela, AP Rolo, CM Palmeira, J Kopecký |
International Journal of Obesity | 2013 |
Adipose tissue browning and metabolic health
A Bartelt, J Heeren |
Nature Reviews Endocrinology | 2013 |
Adaptive thermogenesis in adipocytes: is beige the new brown?
J Wu, P Cohen, BM Spiegelman |
Genes & development | 2013 |
A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis
S Kajimura, M Saito |
Annual Review of Physiology | 2013 |
PPAR and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders
L Wang, R Teng, L Di, H Rogers, H Wu, JB Kopp, CT Noguchi |
Diabetes | 2013 |
The therapeutic potential of brown adipose tissue
KI Stanford, LJ Goodyear |
Hepatobiliary surgery and nutrition | 2013 |
A Role for Phosphodiesterase 3B in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Male Mice
E Guirguis, S Hockman, YW Chung, F Ahmad, O Gavrilova, N Raghavachari, Y Yang, G Niu, X Chen, , S Liu, E Degerman, V Manganiello |
Endocrinology | 2013 |
Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle
T Shan, X Liang, P Bi, S Kuang |
The FASEB Journal | 2013 |
Adipocytes under assault: Environmental disruption of adipose physiology
SM Regnier, RM Sargis |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 |
HDAC9 Knockout Mice Are Protected From Adipose Tissue Dysfunction and Systemic Metabolic Disease During High-Fat Feeding
TK Chatterjee, JE Basford, E Knoll, WS Tong, V Blanco, AL Blomkalns, S Rudich, AB Lentsch, DY Hui, NL Weintraub |
Diabetes | 2013 |
Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes
SH Ro, CH Jung, WS Hahn, X Xu, YM Kim, YS Yun, JM Park, KH Kim, M Seo, TY Ha, EA Arriaga, DA Bernlohr, DH Kim |
Autophagy | 2013 |
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch
J Wang, R Liu, F Wang, J Hong, X Li, M Chen, Y Ke, X Zhang, Q Ma, R Wang, J Shi, B Cui, W Gu, Y Zhang, Z Zhang, W Wang, X Xia, M Liu, G Ning |
Nature Cell Biology | 2013 |
MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse
Y Feuermann, K Kang, O Gavrilova, N Haetscher, SJ Jang, KH Yoo, C Jiang, FJ Gonzalez, GW Robinson, L Hennighausen |
RNA biology | 2013 |
Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
M Saito |
Diabetes & Metabolism Journal | 2013 |
EBF2 Determines and Maintains Brown Adipocyte Identity
S Rajakumari, J Wu, J Ishibashi, HW Lim, AH Giang, KJ Won, RR Reed, P Seale |
Cell Metabolism | 2013 |
Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males
H Yue, J He, Y Ke, H Zhang, C Wang, W Hu, J Gu, W Fu, Y Hu, M Li, Y Liu, Z Zhang |
Acta Pharmacologica Sinica | 2013 |
MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16
H Yin, A Pasut, VD Soleimani, CF Bentzinger, G Antoun, S Thorn, P Seale, P Fernando, W van IJcken, F Grosveld, RA Dekemp, R Boushel, ME Harper, MA Rudnicki |
Cell Metabolism | 2013 |
MicroRNA networks regulate development of brown adipocytes
M Trajkovski, H Lodish |
Trends in Endocrinology & Metabolism | 2013 |
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice
Y Okamatsu-Ogura, K Fukano, A Tsubota, A Uozumi, A Terao, K Kimura, M Saito |
PloS one | 2013 |
Novel nuances of human brown fat
C Scheele, TJ Larsen, S Nielsen |
Adipocyte | 2013 |
Altered white adipose tissue protein profile in C57BL/6J mice displaying delipidative, inflammatory, and browning characteristics after bitter melon seed oil treatment
CH Hsieh, GC Chen, PH Chen, TF Wu, PM Chao |
PloS one | 2013 |
Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes
KA Lo, L Sun |
Bioscience Reports | 2013 |
miR-133a regulates adipocyte browning in vivo
W Liu, P Bi, T Shan, X Yang, H Yin, YX Wang, N Liu, MA Rudnicki, S Kuang |
PLoS genetics | 2013 |
PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue
S Ringholm, JG Knudsen, L Leick, A Lundgaard, MM Nielsen, H Pilegaard |
PloS one | 2013 |
Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice
W Shen, CC Chuang, K Martinez, T Reid, JM Brown, L Xi, L Hixson, R Hopkins, J Starnes, M McIntosh |
Journal of lipid research | 2013 |
A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes
W Liu, T Shan, X Yang, S Liang, P Zhang, Y Liu, X Liu, S Kuang |
Journal of cell science | 2013 |
The Mechanism of White and Brown Adipocyte Differentiation
H Nakagami |
Diabetes & Metabolism Journal | 2013 |
Banting Lecture 2012: Regulation of Adipogenesis: Toward New Therapeutics for Metabolic Disease
BM Spiegelman |
Diabetes | 2013 |
Induction of beige-like adipocytes in 3T3-L1 cells.
Asano H, Kanamori Y, Higurashi S, Nara T, Kato K, Matsui T, Funaba M |
Journal of Veterinary Medical Science | 2013 |
Cardiac natriuretic peptides induce brown fat thermogenic programs in mouse and human adipocytes through p38MAPK
Marica Bordicchia, Dianxin Liu, Ez-Zoubir Amri, Gerard Ailhaud, Paolo Dessi-Fulgheri, Chaoying Zhang, Nobuyuki Takahashi, Riccardo Sarzani, Sheila Collins |
Journal of Clinical Investigation | 2012 |
Chronic overexpression of PNPLA3 variant in mouse liver causes hepatic steatosis
John Zhong Li, Yongcheng Huang, Ruchan Karaman, Pavlina Ivanova, H. Alex Brown, Thomas Roddy, Jose Castro-Perez, Jonathan Cohen, Helen H. Hobbs |
Journal of Clinical Investigation | 2012 |
p62 links beta-adrenergic input with mitochondrial function
Timo D. Mueller, Sang Jun Lee, Martin Jastroch, Dhiraj Kabra, Kerstin Stemmer, Michaela Aichler, Bill Abplanalp, Gayathri Ananthakrishnan, Nakul Bhardwaj, Sheila Collins, Senad Divanovic, Max Endele, Brian Finan, Yuanqing Gao, Kirk Habegger, Jazzmin Hembree, Kristy Heppner, Susanna Hofmann, Jenna Holland, Daniela Küchler, Maria Kutschke, Radha Krishna, Maarit Lehti, Rebecca Oelkrug, Nickki Ottaway, Diego Perez-Tilve, Christine Raver, Axel Karl Walch, Sonja Schriever, John Speakman, Yu-Hua Tseng, Maria Diaz-Meco, Paul Pfluger, Jorge Moscat, Matthias Tschoep |
Journal of Clinical Investigation | 2012 |
Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
L Federico, H Ren, PA Mueller, T Wu, S Liu, J Popovic, EM Blalock, M Sunkara, H Ovaa, HM Albers, GB Mills, AJ Morris, SS Smyth |
Molecular Endocrinology | 2012 |
Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells
M Mori, H Nakagami, G Rodriguez-Araujo, K Nimura, Y Kaneda |
PLoS Biology | 2012 |
Getting 'Smad' about obesity and diabetes
CK Tan, HC Chong, EH Tan, NS Tan |
Nutrition and Diabetes | 2012 |
A novel therapeutic approach to treating obesity through modulation of TGFβ signaling
A Koncarevic, S Kajimura, M Cornwall-Brady, A Andreucci, A Pullen, D Sako, R Kumar, AV Grinberg, K Liharska, JA Ucran, E Howard, BM Spiegelman, J Seehra, J Lachey |
Endocrinology | 2012 |
Adipogenesis
K Sarjeant, JM Stephens |
Cold Spring Harbor perspectives in biology | 2012 |
The adipose organ at a glance
S Cinti |
Disease models & mechanisms | 2012 |
TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis
L Ye, S Kleiner, J Wu, R Sah, RK Gupta, AS Banks, P Cohen, MJ Khandekar, P Boström, RJ Mepani, D Laznik, TM Kamenecka, X Song, W Liedtke, VK Mootha, P Puigserver, PR Griffin, DE Clapham, BM Spiegelman |
Cell | 2012 |
PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
H Ohno, K Shinoda, BM Spiegelman, S Kajimura |
Cell Metabolism | 2012 |
Development of insulin resistance in mice lacking PGC-1α in adipose tissues
S Kleiner, RJ Mepani, D Laznik, L Ye, MJ Jurczak, FR Jornayvaz, JL Estall, DC Bhowmick, GI Shulman, BM Spiegelman |
Proceedings of the National Academy of Sciences | 2012 |
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
FM Fisher, S Kleiner, N Douris, EC Fox, RJ Mepani, F Verdeguer, J Wu, A Kharitonenkov, JS Flier, E Maratos-Flier, BM Spiegelman |
Genes & development | 2012 |
Brown adipose tissue
K Townsend, YH Tseng |
Adipocyte | 2012 |
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
L Qiang, L Wang, N Kon, W Zhao, S Lee, Y Zhang, M Rosenbaum, Y Zhao, W Gu, SR Farmer, D Accili |
Cell | 2012 |
Novel Aspects of Brown Adipose Tissue Biology
J Heeren, H Münzberg |
Endocrinology and metabolism clinics of North America | 2012 |
Overexpression of Endothelial Nitric Oxide Synthase Prevents Diet-Induced Obesity and Regulates Adipocyte Phenotype
BE Sansbury, TD Cummins, Y Tang, J Hellmann, CR Holden, MA Harbeson, Y Chen, RP Patel, M Spite, A Bhatnagar, BG Hill |
Circulation research | 2012 |
A new, powerful player in lipoprotein metabolism: brown adipose tissue
A Bartelt, M Merkel, J Heeren |
Journal of Molecular Medicine | 2012 |
Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice
RC Tsou, DJ Zimmer, BC Jonghe, KK Bence |
Endocrinology | 2012 |
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
JY Huh, G Panagiotou, V Mougios, M Brinkoetter, MT Vamvini, BE Schneider, CS Mantzoros |
Metabolism | 2012 |
Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue
A Galmozzi, N Mitro, A Ferrari, E Gers, F Gilardi, C Godio, G Cermenati, A Gualerzi, E Donetti, D Rotili, S Valente, U Guerrini, D Caruso, A Mai, E Saez, ED Fabiani, M Crestani |
Diabetes | 2012 |
Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity
IJ Lodhi, L Yin, AP Jensen-Urstad, K Funai, T Coleman, JH Baird, MK El Ramahi, B Razani, H Song, F Fu-Hsu, J Turk, CF Semenkovich |
Cell Metabolism | 2012 |
Adipose Tissue, Hormones, and Treatment of Type 1 Diabetes
SC Gunawardana |
Current Diabetes Reports | 2012 |
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
PJ Fernandez-Marcos, EH Jeninga, C Canto, T Harach, VC de Boer, P Andreux, N Moullan, E Pirinen, H Yamamoto, SM Houten, K Schoonjans, J Auwerx |
Scientific Reports | 2012 |
The Heat is on: A New Avenue to Study Brown Fat Formation in Humans
A Scimè |
Frontiers in Endocrinology | 2012 |
Inherent Plasticity of Brown Adipogenesis in White Fat of Mice Allows for Recovery from Effects of Post-Natal Malnutrition
LP Kozak, RA Koza, R Anunciado-Koza, T Mendoza, S Newman |
PloS one | 2012 |
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
FW Kiefer, C Vernochet, P O'Brien, S Spoerl, JD Brown, S Nallamshetty, M Zeyda, TM Stulnig, DE Cohen, CR Kahn, J Plutzky |
Nature Medicine | 2012 |
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
J Wu, P Boström, LM Sparks, L Ye, JH Choi, AH Giang, M Khandekar, KA Virtanen, P Nuutila, G Schaart, K Huang, H Tu, WD van Marken Lichtenbelt, J Hoeks, S Enerbäck, P Schrauwen, BM Spiegelman |
Cell | 2012 |
MyomiR-133 regulates brown fat differentiation through Prdm16
M Trajkovski, K Ahmed, CC Esau, M Stoffel |
Nature Cell Biology | 2012 |
PTEN in cancer, metabolism, and aging
A Ortega-Molina, M Serrano |
Trends in Endocrinology & Metabolism | 2012 |
Irisin, a Novel Myokine Responsible for Exercise Induced Browning of White Adipose Tissue
RD Mahajan, SK Patra |
Indian Journal of Clinical Biochemistry | 2012 |
Association of genes with physiological functions by comparative analysis of pooled expression microarray data
ID Chen, VK Rathi, DS DeAndrade, PY Jay |
Physiological genomics | 2012 |
Human BAT possesses molecular signatures that resemble beige/brite cells
LZ Sharp, K Shinoda, H Ohno, DW Scheel, E Tomoda, L Ruiz, H Hu, L Wang, Z Pavlova, V Gilsanz, S Kajimura |
PloS one | 2012 |
Androgen effects on adipose tissue architecture and function in nonhuman primates
O Varlamov, AE White, JM Carroll, CL Bethea, A Reddy, O Slayden, RW O'Rourke, CT Roberts |
Endocrinology | 2012 |
Therapeutic value of brown adipose tissue
SC Gunawardana |
Adipocyte | 2012 |
A PGC1α-dependent myokine that drives browning of white fat and thermogenesis
P Boström, J Wu, MP Jedrychowski, A Korde, L Ye, JC Lo, KA Rasbach, EA Boström, JH Choi, JZ Long, S Kajimura, MC Zingaretti, BF Vind, H Tu, S Cinti, K Højlund, SP Gygi, BM Spiegelman |
Nature | 2012 |
An Evi1-C/EBP Complex Controls Peroxisome Proliferator-Activated Receptor 2 Gene Expression To Initiate White Fat Cell Differentiation
J Ishibashi, Z Firtina, S Rajakumari, KH Wood, HM Conroe, DJ Steger, P Seale |
Molecular and cellular biology | 2012 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16
E Hondares, M Rosell, J Díaz-Delfín, Y Olmos, M Monsalve, R Iglesias, F Villarroya, M Giralt |
The Journal of biological chemistry | 2011 |
Recent progress in the study of brown adipose tissue
X Yao, S Shan, Y Zhang, H Ying |
Cell & Bioscience | 2011 |
Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion
T Nagare, H Sakaue, M Matsumoto, Y Cao, K Inagaki, M Sakai, Y Takashima, K Nakamura, T Mori, Y Okada, Y Matsuki, E Watanabe, K Ikeda, R Taguchi, N Kamimura, S Ohta, R Hiramatsu, M Kasuga |
The Journal of biological chemistry | 2011 |
Antisense reduction of 11β-hydroxysteroid dehydrogenase type 1 enhances energy expenditure, and insulin sensitivity independent of food intake in C57BL/6J mice on a Western-type diet
G Li, A Hernandez-Ono, RM Crooke, MJ Graham, HN Ginsberg |
Metabolism | 2011 |
Adipose tissue stem cells meet preadipocyte commitment: going back to the future
WP Cawthorn, EL Scheller, OA MacDougald |
Journal of lipid research | 2011 |
Therapeutic Prospects of Metabolically Active Brown Adipose Tissue in Humans
MJ Betz, S Enerbäck |
Frontiers in Endocrinology | 2011 |
Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes
A Krings, S Rahman, S Huang, Y Lu, PJ Czernik, B Lecka-Czernik |
Bone | 2011 |
Developmental Origins of the Adipocyte Lineage: New Insights from Genetics and Genomics Studies
N Billon, C Dani |
Stem Cell Reviews and Reports | 2011 |
White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis
L Cao, EY Choi, X Liu, A Martin, C Wang, X Xu, MJ During |
Cell Metabolism | 2011 |
Forming functional fat: a growing understanding of adipocyte differentiation
AG Cristancho, MA Lazar |
Nature Reviews Molecular Cell Biology | 2011 |
Lecithin Cholesterol Acyltransferase Null Mice Are Protected from Diet-induced Obesity and Insulin Resistance in a Gender-specific Manner through Multiple Pathways*
L Li, MA Hossain, S Sadat, L Hager, L Liu, L Tam, S Schroer, L Huogen, IG Fantus, PW Connelly, M Woo, DS Ng |
The Journal of biological chemistry | 2011 |
Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation
MR Mirbolooki, CC Constantinescu, ML Pan, J Mukherjee |
EJNMMI Research | 2011 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |