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Citations to this article

Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?
Mary-Elizabeth Patti
Mary-Elizabeth Patti
Published July 26, 2010
Citation Information: J Clin Invest. 2010;120(8):2646-2648. https://doi.org/10.1172/JCI44099.
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Commentary Article has an altmetric score of 1

Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?

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Abstract

A growing body of evidence supports an important role for the endocannabinoid system as a regulator of appetite, body weight, and systemic metabolism, which is overactive in obesity and type 2 diabetes. While initial attempts to target this system using the cannabinoid receptor inverse agonist rimonabant were successful in producing modest weight loss and improving obesity-related metabolic complications in humans, adverse central nervous system side effects precluded introduction of this drug into clinical practice. However, new data, presented by Tam and colleagues in this issue of the JCI, demonstrate that selective blockade of peripheral cannabinoid receptors may be a novel successful therapeutic approach.

Authors

Mary-Elizabeth Patti

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Total citations by year

Year: 2013 2010 Total
Citations: 2 1 3
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2010 (1)

Title and authors Publication Year
Prospective influences of circadian clocks in adipose tissue and metabolism
JM Gimble, GM Sutton, BA Bunnell, AA Ptitsyn, ZE Floyd
Nature Reviews Endocrinology 2010

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