Usage Information

PIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001
Morassa Mohseni, Ben Ho Park
Morassa Mohseni, Ben Ho Park
Published July 26, 2010
Citation Information: J Clin Invest. 2010;120(8):2655-2658. https://doi.org/10.1172/JCI44026.
View: Text | PDF
Commentary

PIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001

Abstract

Targeted cancer therapeutics can be effective when patients are preselected to maximize the chance of response. Increasingly, molecular markers such as oncogenic DNA mutations are being exploited to help guide patient preselection. These DNA lesions can predict for either a positive or negative response to a given drug. Finding such predictive biomarkers is an ongoing challenge. New work by Di Nicolantonio and colleagues in this issue of the JCI demonstrates that PI3K catalytic α subunit (PIK3CA) mutations can sensitize cancer cells to the mammalian target of rapamycin (mTOR) inhibitor everolimus. In addition, they show that the concurrent presence of PIK3CA mutations and mutations in either KRAS or BRAF predict for resistance to this drug. These data suggest that mTOR inhibitors currently in use will be ineffective against cancers that have a mutation in either KRAS or BRAF despite having PI3K/AKT/mTOR pathway activation.

Authors

Morassa Mohseni, Ben Ho Park

×

Usage data is cumulative from November 2023 through November 2024.

Usage JCI PMC
Text version 428 38
PDF 116 19
Figure 192 10
Citation downloads 40 0
Totals 776 67
Total Views 843
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement