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Usage Information

Central modulation of pain
Michael H. Ossipov, … , Gregory O. Dussor, Frank Porreca
Michael H. Ossipov, … , Gregory O. Dussor, Frank Porreca
Published November 1, 2010
Citation Information: J Clin Invest. 2010;120(11):3779-3787. https://doi.org/10.1172/JCI43766.
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Review Series Article has an altmetric score of 42

Central modulation of pain

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Abstract

It has long been appreciated that the experience of pain is highly variable between individuals. Pain results from activation of sensory receptors specialized to detect actual or impending tissue damage (i.e., nociceptors). However, a direct correlation between activation of nociceptors and the sensory experience of pain is not always apparent. Even in cases in which the severity of injury appears similar, individual pain experiences may vary dramatically. Emotional state, degree of anxiety, attention and distraction, past experiences, memories, and many other factors can either enhance or diminish the pain experience. Here, we review evidence for “top-down” modulatory circuits that profoundly change the sensory experience of pain.

Authors

Michael H. Ossipov, Gregory O. Dussor, Frank Porreca

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 7,337 2,107
PDF 637 305
Figure 830 24
Citation downloads 173 0
Totals 8,977 2,436
Total Views 11,413
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ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 14 patents
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