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Citations to this article

A balancing act for autophagin
Andreas Till, Suresh Subramani
Andreas Till, Suresh Subramani
Published June 23, 2010
Citation Information: J Clin Invest. 2010;120(7):2273-2276. https://doi.org/10.1172/JCI43238.
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Commentary

A balancing act for autophagin

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Abstract

Autophagy is a tightly regulated catabolic process whereby cells degrade their constituents to dispose of unwanted cytoplasmic elements and recycle nutrients for cellular remodeling. Studies of autophagy in mammals have elicited substantial interest because it is linked to a range of physiologic and pathologic states. In this issue of the JCI, Mariño et al. uncover a role for autophagy in a balance disorder related to inner ear pathologies. Mice lacking the protease autophagy-related 4B (Atg4b, also known as autophagin-1) exhibited a systemic reduction in autophagy and showed defects in the development of otoconia, organic particles that contain calcium carbonate crystals and proteins and that are essential for balance perception (equilibrioception) in mammals. The intriguing aspect of this work is that an autophagy block impairs the secretion and assembly of otoconial proteins, emphasizing a role for autophagy in functions distinct from macromolecule degradation.

Authors

Andreas Till, Suresh Subramani

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Total citations by year

Year: 2019 2018 2017 2016 2015 2013 Total
Citations: 1 2 1 2 1 1 8
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2015 (1)

Title and authors Publication Year
The functional and pathological relevance of autophagy proteases
Álvaro F. Fernández, Carlos López-Otín
Journal of Clinical Investigation 2015

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