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Citations to this article

Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice
David E.G. McNay, … , Eleftheria Maratos-Flier, Jeffrey S. Flier
David E.G. McNay, … , Eleftheria Maratos-Flier, Jeffrey S. Flier
Published December 27, 2011
Citation Information: J Clin Invest. 2012;122(1):142-152. https://doi.org/10.1172/JCI43134.
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Research Article Article has an altmetric score of 25

Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice

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Abstract

In the CNS, the hypothalamic arcuate nucleus (ARN) energy-balance circuit plays a key role in regulating body weight. Recent studies have shown that neurogenesis occurs in the adult hypothalamus, revealing that the ARN energy-balance circuit is more plastic than originally believed. Changes in diet result in altered gene expression and neuronal activity in the ARN, some of which may reflect hypothalamic plasticity. To explore this possibility, we examined the turnover of hypothalamic neurons in mice with obesity secondary to either high-fat diet (HFD) consumption or leptin deficiency. We found substantial turnover of neurons in the ARN that resulted in ongoing cellular remodeling. Feeding mice HFD suppressed neurogenesis, as demonstrated by the observation that these mice both generated fewer new neurons and retained more old neurons. This suppression of neuronal turnover was associated with increased apoptosis of newborn neurons. Leptin-deficient mice also generated fewer new neurons, an observation that was explained in part by a loss of hypothalamic neural stem cells. These data demonstrate that there is substantial postnatal turnover of the arcuate neuronal circuitry in the mouse and reveal the unexpected capacity of diet and leptin deficiency to inhibit this neuronal remodeling. This insight has important implications for our understanding of nutritional regulation of energy balance and brain function.

Authors

David E.G. McNay, Nadege Briançon, Maia V. Kokoeva, Eleftheria Maratos-Flier, Jeffrey S. Flier

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Total
Citations: 2 10 13 9 7 10 9 7 16 5 12 14 20 12 1 147
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2014 (14)

Title and authors Publication Year
Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity
S Bouret, BE Levin, SE Ozanne
Physiological reviews 2014
Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain
E Balland, J Dam, F Langlet, E Caron, S Steculorum, A Messina, S Rasika, A Falluel-Morel, Y Anouar, B Dehouck, E Trinquet, R Jockers, SG Bouret, V Prévot
Cell Metabolism 2014
A new role for the brain in metabolic control
JB Carvalheira, JI Odegaard, A Chawla
Nature Medicine 2014
Hypothalamic Gliosis Associated With High-Fat Diet Feeding Is Reversible in Mice: A Combined Immunohistochemical and Magnetic Resonance Imaging Study
KE Berkseth, SJ Guyenet, SJ Melhorn, D Lee, JP Thaler, EA Schur, MW Schwartz
Endocrinology 2014
The contribution of hypothalamic macroglia to the regulation of energy homeostasis
LB Buckman, KL Ellacott
Frontiers in systems neuroscience 2014
Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus
J Li, Y Tang, S Purkayastha, J Yan, D Cai
Molecular Metabolism 2014
Feed Your Head: Neurodevelopmental Control of Feeding and Metabolism
DA Lee, S Blackshaw
Annual Review of Physiology 2014
Hypothalamic Subependymal Niche: A Novel Site of the Adult Neurogenesis
E Rojczyk-Gołębiewska, A Pałasz, R Wiaderkiewicz
Cellular and Molecular Neurobiology 2014
On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight
FJ Ebling
Hormones and Behavior 2014
Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice
DA Lee, S Yoo, T Pak, J Salvatierra, E Velarde, S Aja, S Blackshaw
Frontiers in neuroscience 2014
Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro
L Sousa-Ferreira, C Aveleira, M Botelho, AR Álvaro, LP de Almeida, C Cavadas
PloS one 2014
Oestradiol and Diet Modulate Energy Homeostasis and Hypothalamic Neurogenesis in the Adult Female Mouse
EP Bless, T Reddy, KD Acharya, BS Beltz, MJ Tetel
Journal of Neuroendocrinology 2014
Cell Proliferation and Neurogenesis in Adult Mouse Brain
OL Bordiuk, K Smith, PJ Morin, MV Semënov, GL Dunbar
PloS one 2014
Hyperlipidemic Diet Causes Loss of Olfactory Sensory Neurons, Reduces Olfactory Discrimination, and Disrupts Odor-Reversal Learning
N Thiebaud, MC Johnson, JL Butler, GA Bell, KL Ferguson, AR Fadool, JC Fadool, AM Gale, DS Gale, DA Fadool
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014

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