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Bernhard Bielesz, … , Volker H. Haase, Katalin Susztak
Published October 18, 2010
Citation Information: J Clin Invest. 2010;120(11):4040-4054. https://doi.org/10.1172/JCI43025.
Citation Information: J Clin Invest. 2010;120(11):4040-4054. https://doi.org/10.1172/JCI43025.
Abstract
Chronic kidney disease is a leading cause of death in the United States. Tubulointerstitial fibrosis (TIF) is considered the final common pathway leading to end-stage renal disease (ESRD). Here, we used pharmacologic, genetic, in vivo, and in vitro experiments to show that activation of the Notch pathway in tubular epithelial cells (TECs) in patients and in mouse models of TIF plays a role in TIF development. Expression of Notch in renal TECs was found to be both necessary and sufficient for TIF development. Genetic deletion of the Notch pathway in TECs reduced renal fibrosis. Consistent with this, TEC-specific expression of active Notch1 caused rapid development of TIF. Pharmacologic inhibition of Notch activation using a γ-secretase inhibitor ameliorated TIF. In summary, our experiments establish that epithelial injury and Notch signaling play key roles in fibrosis development and indicate that Notch blockade may be a therapeutic strategy to reduce fibrosis and ESRD development.
Authors
Bernhard Bielesz, Yasemin Sirin, Han Si, Thiruvur Niranjan, Antje Gruenwald, Seonho Ahn, Hideki Kato, James Pullman, Manfred Gessler, Volker H. Haase, Katalin Susztak
Total citations by year
Citation information
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Nephron. Clinical practice | 2017 |
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Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice
G Yang, Z Zhao, X Zhang, A Wu, Y Huang, Y Miao, M Yang |
Drug design, development and therapy | 2017 |
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Trichostatin A ameliorates renal tubulointerstitial fibrosis through modulation of the JNK-dependent Notch-2 signaling pathway
CW Tung, YC Hsu, CJ Cai, YH Shih, CJ Wang, PJ Chang, CL Lin |
Scientific Reports | 2017 |
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Translational Aspects of Sphingolipid Metabolism in Renal Disorders
AA Daher, TE Jalkh, A Eid, A Fornoni, B Marples, Y Zeidan |
International journal of molecular sciences | 2017 |
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Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury
M Weidenbusch, S Rodler, S Song, S Romoli, JA Marschner, F Kraft, A Holderied, S Kumar, SR Mulay, M Honarpisheh, S Kumar Devarapu, M Lech, HJ Anders |
Bioscience Reports | 2017 |
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The next generation of therapeutics for chronic kidney disease
MD Breyer, K Susztak |
Nature Reviews Drug Discovery | 2016 |
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Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog
M Edeling, G Ragi, S Huang, H Pavenstädt, K Susztak |
Nature Reviews Nephrology | 2016 |
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Epithelial Plasticity versus EMT in Kidney Fibrosis
S Huang, K Susztak |
Trends in Molecular Medicine | 2016 |
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Controversies over the Epithelial-to-Mesenchymal Transition in Liver Fibrosis
K Taura, K Iwaisako, E Hatano, S Uemoto |
Journal of Clinical Medicine | 2016 |
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Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells
Y Zhao, X Qiao, L Wang, TK Tan, H Zhao, Y Zhang, J Zhang, P Rao, Q Cao, Y Wang, Y Wang, YM Wang, VW Lee, SI Alexander, DC Harris, G Zheng |
BMC cell biology | 2016 |
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Matrix metalloproteinase 9-dependent Notch signaling contributes to kidney fibrosis through peritubular endothelial–mesenchymal transition
Y Zhao, X Qiao, TK Tan, H Zhao, Y Zhang, L Liu, J Zhang, L Wang, Q Cao, Y Wang, Y Wang, YM Wang, VW Lee, SI Alexander, DC Harris, G Zheng |
Nephrology Dialysis Transplantation | 2016 |
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Progression of chronic kidney disease: too much cellular talk causes damage
L Gewin, R Zent, A Pozzi |
Kidney International | 2016 |
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Numb contributes to renal fibrosis by promoting tubular epithelial cell cycle arrest at G2/M
F Zhu, W Liu, T Li, J Wan, J Tian, Z Zhou, H Li, Y Liu, FF Hou, J Nie |
Oncotarget | 2016 |
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Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer
TD Bhagat, Y Zou, S Huang, J Park, MB Palmer, C Hu, W Li, N Shenoy, O Giricz, G Choudhary, Y Yu, YA Ko, MC Izquierdo, AS Park, N Vallumsetla, R Laurence, R Lopez, M Suzuki, J Pullman, J Kaner, B Gartrell, AA Hakimi, JM Greally, B Patel, K Benhadji, K Pradhan, A Verma, K Susztak |
The Journal of biological chemistry | 2016 |
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Endothelial sirtuin 1 inactivation enhances capillary rarefaction and fibrosis following kidney injury through Notch activation
Y Kida, JA Zullo, MS Goligorsky |
Biochemical and Biophysical Research Communications | 2016 |
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Notch in fibrosis and as a target of anti-fibrotic therapy
B Hu, SH Phan |
Pharmacological Research | 2016 |
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Hypoxia: The Force that Drives Chronic Kidney Disease
Q Fu, SP Colgan, CS Shelley |
Clinical medicine & research | 2016 |
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Notch: A multi-functional integrating system of microenvironmental signals
B LaFoya, JA Munroe, MM Mia, MA Detweiler, JJ Crow, T Wood, S Roth, B Sharma, AR Albig |
Developmental Biology | 2016 |
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Sonic hedgehog signaling in kidney fibrosis: a master communicator
D Zhou, RJ Tan, Y Liu |
Science China Life Sciences | 2016 |
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Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice
HM Kang, S Huang, K Reidy, SH Han, F Chinga, K Susztak |
Cell Reports | 2016 |
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RNA-binding Protein Musashi Homologue 1 Regulates Kidney Fibrosis by Translational Inhibition of p21 and Numb mRNA
S Jadhav, AK Ajay, P Trivedi, J Seematti, K Pellegrini, F Craciun, VS Vaidya |
The Journal of biological chemistry | 2016 |
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Repeated administration of low-dose cisplatin in mice induces fibrosis
CN Sharp, MA Doll, TV Dupre, PP Shah, M Subathra, D Siow, GE Arteel, J Megyesi, LJ Beverly, LJ Siskind |
American journal of physiology. Renal physiology | 2016 |
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Does Renal Repair Recapitulate Kidney Development?
MH Little, P Kairath |
Journal of the American Society of Nephrology : JASN | 2016 |
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Generation of kidney tubular organoids from human pluripotent stem cells
S Yamaguchi, R Morizane, K Homma, T Monkawa, S Suzuki, S Fujii, M Koda, K Hiratsuka, M Yamashita, T Yoshida, S Wakino, K Hayashi, J Sasaki, S Hori, H Itoh |
Scientific Reports | 2016 |
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Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis
K Takaori, J Nakamura, S Yamamoto, H Nakata, Y Sato, M Takase, M Nameta, T Yamamoto, AN Economides, K Kohno, H Haga, K Sharma, M Yanagita |
Journal of the American Society of Nephrology : JASN | 2015 |
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Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism
SH Han, L Malaga-Dieguez, F Chinga, HM Kang, J Tao, K Reidy, K Susztak |
Journal of the American Society of Nephrology : JASN | 2015 |
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Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury
A Maeshima, S Takahashi, M Nakasatomi, Y Nojima |
Stem Cells International | 2015 |
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Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development
MT Sweetwyne, A Gruenwald, T Niranjan, R Nishinakamura, LJ Strobl, K Susztak |
Diabetes | 2015 |
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Kidney Regeneration: Lessons from Development
T Chiba, N Hukriede, MP de Caestecker |
Current Pathobiology Reports | 2015 |
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Key Fibrogenic Signaling
W He, C Dai |
Current Pathobiology Reports | 2015 |
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Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression
MA Venkatachalam, JM Weinberg, W Kriz, AK Bidani |
Journal of the American Society of Nephrology : JASN | 2015 |
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Application of small RNA sequencing to identify microRNAs in acute kidney injury and fibrosis
KL Pellegrini, CV Gerlach, FL Craciun, K Ramachandran, V Bijol, HT Kissick, VS Vaidya |
Toxicology and Applied Pharmacology | 2015 |
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The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis
R Bansal, J Baarlen, G Storm, J Prakash |
Scientific Reports | 2015 |
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ATF6 pathway of unfolded protein response mediates advanced oxidation protein product-induced hypertrophy and epithelial-to-mesenchymal transition in HK-2 cells
X Tang, X Liang, M Li, T Guo, N Duan, Y Wang, G Rong, L Yang, S Zhang, J Zhang |
Molecular and Cellular Biochemistry | 2015 |
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SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers
MR Hass, H Liow, X Chen, A Sharma, YU Inoue, T Inoue, A Reeb, A Martens, M Fulbright, S Raju, M Stevens, S Boyle, JS Park, MT Weirauch, MR Brent, R Kopan |
Molecular Cell | 2015 |
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Mesenchymal Deficiency of Notch1 Attenuates Bleomycin-Induced Pulmonary Fibrosis
B Hu, Z Wu, D Bai, T Liu, MR Ullenbruch, SH Phan |
The American Journal of Pathology | 2015 |
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Hes1 , an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling
Kai Zhang, Yan Qiong Zhang, Wen Bing Ai, Qing Ting Hu, Qiao Juan Zhang, Lin Yan Wan, Xiao Lian Wang, Chang Bai Liu, Chang Bai Liu, Jiang Feng Wu, Jiang Feng Wu |
World Journal of Gastroenterology | 2015 |
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A proteomics approach to identifying key protein targets involved in VEGF inhibitor mediated attenuation of bleomycin-induced pulmonary fibrosis
YM Kulkarni, S Dutta, AK Iyer, R Venkatadri, V Kaushik, V Ramesh, CA Wright, OJ Semmes, JS Yakisich, N Azad |
PROTEOMICS | 2015 |
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Conditional Knockout of Src Homology 2 Domain-containing Protein Tyrosine Phosphatase-2 in Myeloid Cells Attenuates Renal Fibrosis after Unilateral Ureter Obstruction
DF Xu, XG Cui, JF Teng, K Wang, Y Li, FJ Qu, Q Yuan, QX Wang |
Chinese Medical Journal | 2015 |
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INSIGHTS INTO THE MECHANISMS INVOLVED IN THE EXPRESSION AND REGULATION OF EXTRACELLULAR MATRIX PROTEINS IN DIABETIC NEPHROPATHY
Hu C, Sun L, Xiao L, Han Y, Fu X, Xiong X, Xu X, Liu Y, Yang S, Liu F, Kanwar YS |
Current medicinal chemistry | 2015 |
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Kidney fibrosis: recent advances
Jeremy Duffield |
Journal of Clinical Investigation | 2014 |
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Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis
J Megyesi, A Tarcsafalvi, S Li, R Hodeify, NS Seng, D Portilla, PM Price |
American journal of physiology. Renal physiology | 2014 |
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Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
HM Kang, SH Ahn, P Choi, YA Ko, SH Han, F Chinga, AS Park, J Tao, K Sharma, J Pullman, EP Bottinger, IJ Goldberg, K Susztak |
Nature Medicine | 2014 |
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Immune system modulation of kidney regeneration—mechanisms and implications
HJ Anders |
Nature Reviews Nephrology | 2014 |
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Functional Genomic Annotation of Genetic Risk Loci Highlights Inflammation and Epithelial Biology Networks in CKD
N Ledo, YA Ko, AS Park, HM Kang, SY Han, P Choi, K Susztak |
Journal of the American Society of Nephrology : JASN | 2014 |
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Microvascular pericytes in healthy and diseased kidneys
SY Pan, YT Chang, SL Lin |
International journal of nephrology and renovascular disease | 2014 |
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Kick it up a notch: Notch signaling and kidney fibrosis
MT Sweetwyne, J Tao, K Susztak |
Kidney International Supplements | 2014 |
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miR-34c attenuates epithelial-mesenchymal transition and kidney fibrosis with ureteral obstruction
R Morizane, S Fujii, T Monkawa, K Hiratsuka, S Yamaguchi, K Homma, H Itoh |
Scientific Reports | 2014 |
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Activation of Notch3 in Glomeruli Promotes the Development of Rapidly Progressive Renal Disease
FE Machhour, Z Keuylian, P Kavvadas, JC Dussaule, C Chatziantoniou |
Journal of the American Society of Nephrology : JASN | 2014 |
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Connective Tissue Growth Factor is a Target of Notch Signaling in Cells of the Osteoblastic Lineage
E Canalis, S Zanotti, A Smerdel-Ramoya |
Bone | 2014 |
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Renal recovery
SL Goldstein, L Chawla, C Ronco, JA Kellum |
Critical Care | 2014 |
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Developmental signaling: Does it bridge the gap between cilia dysfunction and renal cystogenesis?: DEVELOPMENTAL SIGNALING
PV Tran, M Sharma, X Li, JP Calvet |
Birth Defects Research Part C Embryo Today Reviews | 2014 |
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Akt2 Is Involved in Loss of Epithelial Cells and Renal Fibrosis following Unilateral Ureteral Obstruction
A Lan, J Zhang, Z Xiao, X Peng, Y Qi, J Du |
PloS one | 2014 |
|
Role of Moesin in Renal Fibrosis
YX Chen, W Zhang, WM Wang, XL Yu, YM Wang, MJ Zhang, N Chen, AS Charonis |
PloS one | 2014 |
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The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury
IG Gomez, JS Duffield |
Kidney International Supplements | 2014 |
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In Vivo Notch Signaling Blockade Induces Abnormal Spermatogenesis in the Mouse
D Murta, M Batista, A Trindade, E Silva, D Henrique, A Duarte, L Lopes-da-Costa, W Yan |
PloS one | 2014 |
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Plasticity of Renal Erythropoietin-Producing Cells Governs Fibrosis
T Souma, S Yamazaki, T Moriguchi, N Suzuki, I Hirano, X Pan, N Minegishi, M Abe, H Kiyomoto, S Ito, M Yamamoto |
Journal of the American Society of Nephrology : JASN | 2013 |
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γ-Secretase Inhibitors and Modulators
TE Golde, EH Koo, KM Felsenstein, BA Osborne, L Miele |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 |
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Role of Notch signaling in the mammalian heart
XL Zhou, JC Liu |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2013 |
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Overexpression of MMP-7 increases collagen 1A2 in the aging kidney
A Ślusarz, LN Nichols, EA Grunz-Borgmann, G Chen, AD Akintola, JM Catania, RC Burghardt, JP Trzeciakowski, AR Parrish |
Physiological Reports | 2013 |
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Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis
G Campanholle, G Ligresti, SA Gharib, JS Duffield |
American journal of physiology. Cell physiology | 2013 |
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Myofibroblasts in Fibrotic Kidneys
N Nakagawa, JS Duffield |
Current Pathobiology Reports | 2013 |
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Evidence for and against epithelial-to-mesenchymal transition in the liver
G Xie, AM Diehl |
AJP Gastrointestinal and Liver Physiology | 2013 |
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Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction
S Li, N Mariappan, J Megyesi, B Shank, K Kannan, S Theus, PM Price, JS Duffield, D Portilla |
American journal of physiology. Renal physiology | 2013 |
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Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss
T Ueno, N Kobayashi, M Nakayama, Y Takashima, T Ohse, I Pastan, JW Pippin, SJ Shankland, N Uesugi, T Matsusaka, M Nagata |
Kidney International | 2013 |
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Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis
VS LeBleu, Y Teng, JT O'Connell, D Charytan, GA Müller, CA Müller, H Sugimoto, R Kalluri |
Nature Medicine | 2013 |
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Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development
YA Ko, D Mohtat, M Suzuki, AS Park, MC Izquierdo, SY Han, HM Kang, H Si, T Hostetter, JM Pullman, M Fazzari, A Verma, D Zheng, JM Greally, K Susztak |
Genome biology | 2013 |
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Notch Signaling Molecules Activate TGF- β in Rat Mesangial Cells under High Glucose Conditions
L Liu, C Gao, G Chen, X Li, J Li, Q Wan, Y Xu |
Journal of Diabetes Research | 2013 |
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Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
D Murta, M Batista, E Silva, A Trindade, D Henrique, A Duarte, L Lopes-da-Costa |
PloS one | 2013 |
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γ-Secretase inhibition promotes fibrotic effects of albumin in proximal tubular epithelial cells
C Slattery, Y Jang, WA Kruger, DH Hryciw, A Lee, P Poronnik |
British Journal of Pharmacology | 2013 |
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Sonic Hedgehog Signaling Mediates Epithelial–Mesenchymal Communication and Promotes Renal Fibrosis
H Ding, D Zhou, S Hao, L Zhou, W He, J Nie, FF Hou, Y Liu |
Journal of the American Society of Nephrology : JASN | 2012 |
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Angiotensin II Contributes to Renal Fibrosis Independently of Notch Pathway Activation
C Lavoz, R Rodrigues-Diez, A Benito-Martin, S Rayego-Mateos, RR Rodrigues-Diez, M Alique, A Ortiz, S Mezzano, J Egido, M Ruiz-Ortega |
PloS one | 2012 |
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New Insights into the Mechanism of Notch Signalling in Fibrosis
N Kavian, A Servettaz, B Weill, F Batteux |
The open rheumatology journal | 2012 |
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Cdc42-Interacting Protein-4 Promotes TGF-Β1-Induced Epithelial-Mesenchymal Transition and Extracellular Matrix Deposition in Renal Proximal Tubular Epithelial Cells
S Bai, R Zeng, Q Zhou, W Liao, Y Zhang, C Xu, M Han, G Pei, L Liu, X Liu, Y Yao, G Xu |
International journal of biological sciences | 2012 |
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Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis
CF Wu, WC Chiang, CF Lai, FC Chang, YT Chen, YH Chou, TH Wu, GR Linn, H Ling, KD Wu, TJ Tsai, YM Chen, JS Duffield, SL Lin |
The American Journal of Pathology | 2012 |
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Targeting Pericyte Differentiation as a Strategy to Modulate Kidney Fibrosis in Diabetic Nephropathy
BD Humphreys |
Seminars in Nephrology | 2012 |
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Systems approach identifies HIPK2 as a critical regulator of kidney fibrosis
Y Jin, K Ratnam, PY Chuang, Y Fan, Y Zhong, Y Dai, AR Mazloom, EY Chen, V D'Agati, H Xiong, MJ Ross, N Chen, A Ma'ayan, JC He |
Nature Medicine | 2012 |
|
Host responses in tissue repair and fibrosis
JS Duffield, M Lupher, VJ Thannickal, TA Wynn |
Annual review of pathology | 2012 |
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Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells
R Du, W Sun, L Xia, A Zhao, Y Yu, L Zhao, H Wang, C Huang, S Sun |
PloS one | 2012 |
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Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
B Hinz, SH Phan, VJ Thannickal, M Prunotto, A Desmoulière, J Varga, OD Wever, M Mareel, G Gabbiani |
The American Journal of Pathology | 2012 |
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Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats
Y Chen, S Zheng, D Qi, S Zheng, J Guo, S Zhang, Z Weng |
PloS one | 2012 |
|
Hedgehog-Gli Pathway Activation during Kidney Fibrosis
SL Fabian, RR Penchev, BS Jacques, AN Rao, P Sipilä, KA West, AP McMahon, BD Humphreys |
The American Journal of Pathology | 2012 |
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Injection of Amniotic Fluid Stem Cells Delays Progression of Renal Fibrosis
S Sedrakyan, SD Sacco, A Milanesi, L Shiri, A Petrosyan, R Varimezova, D Warburton, KV Lemley, RE Filippo, L Perin |
Journal of the American Society of Nephrology : JASN | 2012 |
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Notch signaling in diabetic nephropathy
R Bonegio, K Susztak |
Experimental Cell Research | 2012 |
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PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis
R Lan, H Geng, AJ Polichnowski, PK Singha, P Saikumar, DG McEwen, KA Griffin, R Koesters, JM Weinberg, AK Bidani, W Kriz, MA Venkatachalam |
American journal of physiology. Renal physiology | 2012 |
|
Notch3 regulates the activation of hepatic stellate cells
YX Chen, ZH Weng, SL Zhang |
World journal of gastroenterology : WJG | 2012 |
|
All-Trans Retinoic Acid Treatment Is Associated with Prohibitin Expression in Renal Interstitial Fibrosis Rats
TB Zhou, YH Qin, ZY Li, HL Xu, YJ Zhao, FY Lei |
International journal of molecular sciences | 2012 |
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Discovery and Validation of a Molecular Signature for the Noninvasive Diagnosis of Human Renal Allograft Fibrosis:
D Anglicheau, T Muthukumar, A Hummel, R Ding, VK Sharma, D Dadhania, SV Seshan, JE Schwartz, M Suthanthiran |
Transplantation | 2012 |
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Molecular targets for treatment of kidney fibrosis
PY Chuang, MC Menon, JC He |
Journal of Molecular Medicine | 2012 |
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New susceptibility loci associated with kidney disease in type 1 diabetes
N Sandholm, RM Salem, AJ McKnight, EP Brennan, C Forsblom, T Isakova, GJ McKay, WW Williams, DM Sadlier, VP Mäkinen, EJ Swan, C Palmer, AP Boright, E Ahlqvist, HA Deshmukh, BJ Keller, H Huang, AJ Ahola, E Fagerholm, D Gordin, V Harjutsalo, B He, O Heikkilä, K Hietala, J Kytö, P Lahermo, M Lehto, R Lithovius, AM Osterholm, M Parkkonen, J Pitkäniemi, M Rosengård-Bärlund, M Saraheimo, C Sarti, J Söderlund, A Soro-Paavonen, A Syreeni, LM Thorn, H Tikkanen, N Tolonen, K Tryggvason, J Tuomilehto, J Wadén, GV Gill, S Prior, C Guiducci, DB Mirel, A Taylor, SM Hosseini, , HH Parving, P Rossing, L Tarnow, C Ladenvall, F Alhenc-Gelas, P Lefebvre, V Rigalleau, R Roussel, DA Tregouet, A Maestroni, S Maestroni, H Falhammar, T Gu, A Möllsten, D Cimponeriu, M Ioana, M Mota, E Mota, C Serafinceanu, M Stavarachi, RL Hanson, RG Nelson, M Kretzler, HM Colhoun, NM Panduru, HF Gu, K Brismar, G Zerbini, S Hadjadj, M Marre, L Groop, M Lajer, SB Bull, D Waggott, AD Paterson, DA Savage, SC Bain, F Martin, JN Hirschhorn, C Godson, JC Florez, PH Groop, AP Maxwell |
PLoS genetics | 2012 |
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Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway
NJ Sarma, V Tiriveedhi, V Subramanian, S Shenoy, JS Crippin, WC Chapman, T Mohanakumar |
PloS one | 2012 |
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Cellular senescence limits regenerative capacity and allograft survival
H Braun, BM Schmidt, M Raiss, A Baisantry, D Mircea-Constantin, S Wang, ML Gross, M Serrano, R Schmitt, A Melk |
Journal of the American Society of Nephrology : JASN | 2012 |
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Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis
Y Xia, SR Campbell, A Broder, L Herlitz, M Abadi, P Wu, JS Michaelson, LC Burkly, C Putterman |
Clinical Immunology | 2012 |
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Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells
BM Grabias, K Konstantopoulos |
The FASEB Journal | 2012 |
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Role of mTOR for podocyte function and diabetic nephropathy in humans and mice
Markus Gödel, Björn Hartleben, Nadja Herbach, Shuya Liu, Stefan Zschiedrich, Shun Lu, Andrea Debreczeni-Mór, Maja T. Lindenmeyer, Maria-Pia Rastaldi, Götz Hartleben, Thorsten Wiech, Alessia Fornoni, Robert G Nelson, Matthias Kretzler, Rüdiger Wanke, Hermann Pavenstädt, Dontscho Kerjaschki, Clemens D. Cohen, Michael N. Hall, Markus A. Rüegg, Ken Inoki, Gerd Walz, Tobias B. Huber |
Journal of Clinical Investigation | 2011 |
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Epithelial-Mesenchymal-Transition (EMT) in Kidney Fibrosis: Fact or Fantasy?
Wilhelm Kriz, Brigitte Kaissling, Michel Le Hir |
Journal of Clinical Investigation | 2011 |
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Cellular and molecular mechanisms of renal fibrosis
Y Liu |
Nature Reviews Nephrology | 2011 |
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The origin of interstitial myofibroblasts in chronic kidney disease
I Grgic, JS Duffield, BD Humphreys |
Pediatric Nephrology | 2011 |
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Elongin C is a mediator of Notch4 activity in human renal tubule cells
TD Cummins, MD Mendenhall, MN Lowry, E A.Korte, MT Barati, SJ Khundmiri, SA Salyer, JB Klein, DW Powell |
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics | 2011 |
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The Role of Notch in the Kidney, Development and Beyond
Y Sirin, K Susztak |
The Journal of Pathology | 2011 |
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The story of Notch and chronic kidney disease
S Sharma, Y Sirin, K Susztak |
Current Opinion in Nephrology and Hypertension | 2011 |
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NOTCH1 regulates migration and invasion of skin cancer cells by E-cadherin repression
Z Wang, L Liu, M Wang, M Shen, J Li, J Liu, C Li, C Xin, S Zhu, Q Mei, Y Wang |
Molecular and Cellular Biochemistry | 2011 |
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Frontiers in Research: Chronic Kidney Diseases: The pivotal role of pericytes in kidney fibrosis
Y Kida, JS Duffield |
Clinical and experimental pharmacology & physiology | 2011 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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