JCI - Citations to TLR8 deficiency leads to autoimmunity in mice

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TLR8 deficiency leads to autoimmunity in mice

Olivier Demaria, … , Richard A. Flavell, Lena Alexopoulou

Olivier Demaria, … , Richard A. Flavell, Lena Alexopoulou

Published September 1, 2010
Citation Information: J Clin Invest. 2010;120(10):3651-3662. https://doi.org/10.1172/JCI42081.

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Research Article Autoimmunity

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Citations to this article (109)

Title and authors	Publication	Year
Interleukin-32 positive immune and resident cells in kidney samples from lupus patients: a pilot study Truglia S, Ciccia F, Mancuso S, Capozzi A, Rizzo A, Spinelli FR, Ceccarelli F, Colasanti T, Garufi C, Miranda F, Sorice M, Alessandri C, Conti F	Frontiers in Immunology	2025
TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS Hanah Georges, Caterina Cassin, Mancy Tong, Vikki Abrahams	Immunology	2024
Exploring the association between rosacea and acne by integrated bioinformatics analysis. Liang J, Chen Y, Wang Z, Wang Y, Mu S, Zhang D, Wang Z, Zeng W	Scientific Reports	2024
MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus Wang T, Song D, Li X, Luo Y, Yang D, Liu X, Kong X, Xing Y, Bi S, Zhang Y, Hu T, Zhang Y, Dai S, Shao Z, Chen D, Hou J, Ballestar E, Cai J, Zheng F, Yang JY	Cell communication and signaling : CCS	2024
Altered X-chromosome inactivation predisposes to autoimmunity Huret C, Ferrayé L, David A, Mohamed M, Valentin N, Charlotte F, Savignac M, Goodhardt M, Guéry JC, Rougeulle C, Morey C	Science Advances	2024
Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus von Hofsten S, Fenton KA, Pedersen HL	International journal of molecular sciences	2024
Tlr7 drives sex- and tissue-dependent effects in Sjögren’s disease Punnanitinont A, Biswas S, Kasperek EM, Osinski J, Zhu C, Miecznikowski JC, Romano RA, Kramer JM	Frontiers in Cell and Developmental Biology	2024
Roles of Toll-like Receptor Signaling in Inflammatory Bone Resorption Tominari T, Matsumoto C, Tanaka Y, Shimizu K, Takatoya M, Sugasaki M, Karouji K, Kasuga U, Miyaura C, Miyata S, Itoh Y, Hirata M, Inada M	Biology	2024
Possible involvement of Toll-like receptor 8-positive monocytes/macrophages in the pathogenesis of Sjögren’s disease Yan L, Miyahara Y, Sakamoto M, Kaneko N, Chen H, Sameshima J, Kido H, Yokomizo S, Sueyoshi T, Nagano H, Ohyama Y, Nakamura S, Kawano S, Moriyama M	Frontiers in Immunology	2024
Sterile activation of RNA-sensing pathways in autoimmunity Li J, Zhu J, Yang H, Hou F	Journal of Molecular Cell Biology	2024
The path ahead for understanding TLR-driven systemic autoimmunity Hamerman JA, Barton GM	Current opinion in immunology	2024
Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy Hawtin S, André C, Collignon-Zipfel G, Appenzeller S, Bannert B, Baumgartner L, Beck D, Betschart C, Boulay T, Brunner HI, Ceci M, Deane J, Feifel R, Ferrero E, Kyburz D, Lafossas F, Loetscher P, Merz-Stoeckle C, Michellys P, Nuesslein-Hildesheim B, Raulf F, Rush JS, Ruzzante G, Stein T, Zaharevitz S, Wieczorek G, Siegel R, Gergely P, Shisha T, Junt T	Cell reports. Medicine	2023
TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K	Journal of Experimental Medicine	2023
TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells Youness A, Cenac C, Faz-López B, Grunenwald S, Barrat FJ, Chaumeil J, Mejía JE, Guéry JC	Biology of sex differences	2023
TLR7 promotes skin inflammation via activating NFκB-mTORC1 axis in rosacea Huang Y, Liu D, Chen M, Xu S, Peng Q, Zhu Y, Long J, Liu T, Deng Z, Xie H, Li J, Liu F, Xiao W	PeerJ	2023
Sex-specific differences in primary Sjögren's disease Punnanitinont A, Kramer JM	Frontiers in Dental Medicine	2023
Endosomal TLR3 signaling in stromal osteoblasts induces prostaglandin E2–mediated inflammatory periodontal bone resorption Tominari T, Akita M, Matsumoto C, Hirata M, Yoshinouchi S, Tanaka Y, Karouji K, Itoh Y, Maruyama T, Miyaura C, Numabe Y, Inada M	The Journal of biological chemistry	2022
Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics Vervaeke P, Borgos SE, Sanders NN, Combes F	Advanced Drug Delivery Reviews	2022
Development of High Fat Diet-Induced Hyperinsulinemia in Mice Is Enhanced by Co-treatment With a TLR7 Agonist. Kakalij RM, Dsouza DL, Boesen EI	Frontiers in physiology	2022
Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling. Lee CYQ, Chan YT, Cheok YY, Tan GMY, Tang TF, Cheong HC, Vadivelu J, Abdullah S, Looi CY, Wong WF	Journal of Immunology Research	2022
Nucleic acid-sensing toll-like receptors: Important players in Sjögren’s syndrome Alexopoulou L	Frontiers in immunology	2022
TLR7 agonism accelerates disease in a mouse model of primary Sjögren's syndrome and drives expansion of T-bet(+) B cells. Punnanitinont A, Kasperek EM, Kiripolsky J, Zhu C, Miecznikowski JC, Kramer JM	Frontiers in immunology	2022
TLR7 Signaling Drives the Development of Sjögren’s Syndrome Y Wang, A Roussel-Queval, L Chasson, NH Kazazian, L Marcadet, A Nezos, MH Sieweke, C Mavragani, L Alexopoulou	Frontiers in immunology	2021
Role of Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems H Li, S Liu, J Han, S Li, X Gao, M Wang, J Zhu, T Jin	Frontiers in immunology	2021
Innate Immune Sensing of Viruses and Its Consequences for the Central Nervous System H Singh, J Koury, M Kaul	Viruses	2021
Cell Surface Expression of Endosomal Toll-Like Receptors—A Necessity or a Superfluous Duplication? MB Mielcarska, M Bossowska-Nowicka, FN Toka	Frontiers in immunology	2021
Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function J Aluri, A Bach, S Kaviany, LC Paracatu, M Kitcharoensakkul, MA Walkiewicz, CD Putnam, M Shinawi, N Saucier, EM Rizzi, MT Harmon, MP Keppel, M Ritter, M Similuk, E Kulm, M Joyce, AA de Jesus, R Goldbach-Mansky, YS Lee, M Cella, PL Kendall, MC Dinauer, JJ Bednarski, C Bemrich-Stolz, SW Canna, SM Abraham, MM Demczko, J Powell, SM Jones, AM Scurlock, SS Ravin, JJ Bleesing, JA Connelly, VK Rao, LG Schuettpelz, MA Cooper	Blood	2021
The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent Y Cheng, N Borcherding, A Ogunsakin, CD Lemke-Miltner, KN Gibson-Corley, A Rajan, AB Choi, W Wongpattaraworakul, CH Chan, AK Salem, GJ Weiner, AL Simons	Scientific Reports	2021
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis Y Zhu, Z Wu, W Yan, F Shao, B Ke, X Jiang, J Gao, W Guo, Y Lai, H Ma, D Chen, Q Xu, Y Sun	EMBO Molecular Medicine	2021
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy L Amon, L Hatscher, L Heger, D Dudziak, CH Lehmann	Pharmaceutics	2020
TLR7/8 in the Pathogenesis of Parkinson’s Disease M Campolo, A Filippone, C Biondo, G Mancuso, G Casili, M Lanza, S Cuzzocrea, E Esposito, I Paterniti	International journal of molecular sciences	2020
RNA Sensing of Mycobacterium tuberculosis and Its Impact on TB Vaccination Strategies S Burkert, RR Schumann	Human vaccines	2020
Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study M Juncal-Ruiz, L Riesco-Davila, J Vazquez-Bourgon, VO de la Foz, JM Son, R Ayesa-Arriola, E Setien-Suero, JC Leza, M Lopez-Hoyos, B Crespo-Facorro	International journal of molecular sciences	2020
A Novel Small-Molecule Inhibitor of Endosomal TLRs Reduces Inflammation and Alleviates Autoimmune Disease Symptoms in Murine Models MC Patra, A Achek, GY Kim, S Panneerselvam, HJ Shin, WY Baek, WH Lee, J Sung, U Jeong, EY Cho, W Kim, E Kim, CH Suh, S Choi	Cells	2020
Sex and suicide: The curious case of Toll-like receptors PA Navarro-Costa, A Molaro, CS Misra, CD Meiklejohn, PJ Ellis	PLoS Biology	2020
Development of a novel TLR8 agonist for cancer immunotherapy Wang Y, Yang H, Li H, Zhao S, Zeng Y, Zhang P, Lin X, Sun X, Wang L, Fu G, Gao Y, Wang P, Gao D		2020
Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells C Coch, B Hommertgen, T Zillinger, J Daßler-Plenker, B Putschli, M Nastaly, BM Kümmerer, JF Scheunemann, B Schumak, S Specht, M Schlee, W Barchet, A Hoerauf, E Bartok, G Hartmann	Frontiers in immunology	2019
Lupus Autoimmunity and Metabolic Parameters Are Exacerbated Upon High Fat Diet-Induced Obesity Due to TLR7 Signaling NH Kazazian, Y Wang, A Roussel-Queval, L Marcadet, L Chasson, C Laprie, B Desnues, J Charaix, M Irla, L Alexopoulou	Frontiers in immunology	2019
Beyond defense: regulation of neuronal morphogenesis and brain functions via Toll-like receptors CY Chen, YC Shih, YF Hung, YP Hsueh	Journal of Biomedical Science	2019
Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice SK Nanda, T Petrova, F Marchesi, M Gierlinski, M Razsolkov, KL Lee, SW Wright, VR Rao, P Cohen, JS Arthur		2019
Receptor targeting drug delivery strategies and prospects in the treatment of rheumatoid arthritis J Emami, Z Ansarypour	Research in Pharmaceutical Sciences	2019
TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG ZJ Zhang, JS Guo, SS Li, XB Wu, DL Cao, BC Jiang, PB Jing, XQ Bai, CH Li, ZH Wu, Y Lu, YJ Gao	Journal of Experimental Medicine	2018
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TLR8: No gain, no pain FJ Barrat	Journal of Experimental Medicine	2018
HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways M Alam, D Yang, A Trivett, TJ Meyer, JJ Oppenheim	Frontiers in immunology	2018
Rational Design and In Vivo Characterization of Vaccine Adjuvants ST Schmidt, GK Pedersen, D Christensen	ILAR journal / National Research Council, Institute of Laboratory Animal Resources	2018
Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8 Ah Kioon MD, Tripodo C, Fernandez D, Kirou KA, Spiera RF, Crow MK, Gordon JK, Barrat FJ	Science Translational Medicine	2018
TLRs, future potential therapeutic targets for RA HA Elshabrawy, AE Essani, Z Szekanecz, DA Fox, S Shahrara	Autoimmunity Reviews	2017
TLR7 Deficiency Leads to TLR8 Compensative Regulation of Immune Response against JEV in Mice M Awais, K Wang, X Lin, W Qian, N Zhang, C Wang, K Wang, L Zhao, ZF Fu, M Cui	Frontiers in immunology	2017
Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes Z Lateef, G Gimenez, ES Baker, VK Ward	BMC Genomics	2017
RNA sensors of the innate immune system and their detection of pathogens: RNA SENSORS N Chen, P Xia, S Li, T Zhang, TT Wang, J Zhu	IUBMB Life	2017
The contributions of lung macrophage and monocyte heterogeneity to influenza pathogenesis M Duan, ML Hibbs, W Chen	Immunology and Cell Biology	2016
TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice AM Paul, D Acharya, L Le, P Wang, DS Stokic, AA Leis, L Alexopoulou, T Town, RA Flavell, E Fikrig, F Bai	Journal of immunology (Baltimore, Md. : 1950)	2016
Blood-stage malaria of Plasmodium chabaudi induces differential Tlr expression in the liver of susceptible and vaccination-protected Balb/c mice S Al-Quraishy, MA Dkhil, S Alomar, AA Abdel-Baki, D Delic, F Wunderlich, MJ Araúzo-Bravo	Parasitology Research	2016
Guanine-Modified Inhibitory Oligonucleotides Efficiently Impair TLR7- and TLR9-Mediated Immune Responses of Human Immune Cells F Römmler, M Hammel, A Waldhuber, T Müller, M Jurk, E Uhlmann, H Wagner, J Vollmer, T Miethke, L Zhang	PloS one	2015
Human dendritic cell subsets and function in health and disease M O’Keeffe, WH Mok, KJ Radford	Cellular and Molecular Life Sciences	2015
Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus K Ma, J Li, Y Fang, L Lu	International journal of molecular sciences	2015
Human and Mouse Mononuclear Phagocyte Networks: A Tale of Two Species? G Reynolds, M Haniffa	Frontiers in immunology	2015
Toll-like receptor 8 deletion accelerates autoimmunity in a mouse model of lupus through a Toll-like receptor 7-dependent mechanism NL Tran, C Manzin-Lorenzi, ML Santiago-Raber	Immunology	2015
Translating nucleic acid-sensing pathways into therapies T Junt, W Barchet	Nature Reviews Immunology	2015
Molecular cloning and functional characterization of murine toll‑like receptor 8 T Li, X He, H Jia, G Chen, S Zeng, Y Fang, Q Jin, Z Jing	Molecular medicine reports	2015
Identification of a novel TLR7 endogenous ligand in RA synovial fluid that can provoke arthritic joint inflammation: Role of TLR7 ligand in RA S Kim, Z Chen, AB Essani, HA Elshabrawy, MV Volin, S Volkov, W Swedler, S Arami, N Sweiss, S Shahrara	Arthritis & Rheumatology	2015
Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population CM Wang, SW Chang, YJ Wu, JC Lin, HH Ho, TC Chou, B Yang, J Wu, JY Chen	Scientific Reports	2014
Immune sensing of nucleic acids in inflammatory skin diseases O Demaria, JD Domizio, M Gilliet	Seminars in Immunopathology	2014
Humanized TLR7/8 Expression Drives Proliferative Multisystemic Histiocytosis in C57BL/6 Mice JM Snyder, PM Treuting, L Nagy, C Yam, J Yi, A Brasfield, LP Nguyen, AM Hajjar, T Akiyama	PloS one	2014
The expression of Toll-like receptor 8 and its relationship with VEGF and Bcl-2 in cervical cancer Y Zhang, H Yang, PA Barnie, P Yang, Z Su, J Chen, Z Jiao, L Lu, S Wang, H Xu	International journal of medical sciences	2014
Phagosomal TLR signaling upon Borrelia burgdorferi infection JL Cervantes, KL Hawley, SJ Benjamin, B Weinerman, SM Luu, JC Salazar	Frontiers in Cellular and Infection Microbiology	2014
Emerging role of endosomal toll-like receptors in rheumatoid arthritis R Thwaites, G Chamberlain, S Sacre	Frontiers in immunology	2014
TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice B Desnues, AB Macedo, A Roussel-Queval, J Bonnardel, S Henri, O Demaria, L Alexopoulou	Proceedings of the National Academy of Sciences	2014
Liver-inherent immune system: its role in blood-stage malaria F Wunderlich, S Al-Quraishy, MA Dkhil	Frontiers in microbiology	2014
Activation of NF- B via Endosomal Toll-Like Receptor 7 (TLR7) or TLR9 Suppresses Murine Herpesvirus 68 Reactivation F Haas, K Yamauchi, M Murat, M Bernasconi, N Yamanaka, RF Speck, D Nadal	Journal of virology	2014
Role of Toll-Like Receptor 13 in Innate Immune Recognition of Group B Streptococci G Signorino, N Mohammadi, F Patane, M Buscetta, M Venza, I Venza, G Mancuso, A Midiri, L Alexopoulou, G Teti, C Biondo, C Beninati	Infection and immunity	2014
Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus: Innate immunity BR Umiker, S Andersson, L Fernandez, P Korgaokar, A Larbi, M Pilichowska, CC Weinkauf, HH Wortis, JF Kearney, T Imanishi-Kari	European Journal of Immunology	2014
Testosterone persistently dysregulates hepatic expression of Tlr6 and Tlr8 induced by Plasmodium chabaudi malaria S Al-Quraishy, MA Dkhil, AA Abdel-Baki, MJ Araúzo-Bravo, D Delic, F Wunderlich	Parasitology Research	2014
Toll-like receptor 7 rapidly relaxes human airways MG Drake, GD Scott, BJ Proskocil, AD Fryer, DB Jacoby, EH Kaufman	American journal of respiratory and critical care medicine	2013
Innate Immune Responses in the CNS: Role of Toll-Like Receptors, Mechanisms, and Therapeutic Opportunities in Multiple Sclerosis G Podda, M Nyirenda, J Crooks, B Gran	Journal of Neuroimmune Pharmacology	2013
Role of Nucleic Acid–Sensing TLRs in Diverse Autoantibody Specificities and Anti-Nuclear Antibody–Producing B Cells YT Koh, JC Scatizzi, JD Gahan, BR Lawson, R Baccala, KM Pollard, BA Beutler, AN Theofilopoulos, DH Kono	Journal of immunology (Baltimore, Md. : 1950)	2013
Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9 ER Kandimalla, L Bhagat, D Wang, D Yu, T Sullivan, NL Monica, S Agrawal	Nucleic Acids Research	2013
1,25-Dihydroxyvitamin D3 suppresses TLR8 expression and TLR8-mediated inflammatory responses in monocytes in vitro and experimental autoimmune encephalomyelitis in vivo B Li, DJ Baylink, C Deb, C Zannetti, F Rajaallah, W Xing, MH Walter, KH Lau, X Qin	PloS one	2013
The TLR family protein RP105/MD-1 complex Y Nagai, Y Watanabe, K Takatsu	Adipocyte	2013
Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors X He, H Jia, Z Jing, D Liu	Acta Biochimica et Biophysica Sinica	2013
Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes JL Cervantes, CJ la Vake, B Weinerman, S Luu, C O'Connell, PH Verardi, JC Salazar	Journal of leukocyte biology	2013
Impaired toll-like receptor 8 signaling in multiple sclerosis TP Johnson, R Tyagi, K Patel, N Schiess, PA Calabresi, A Nath	Journal of Neuroinflammation	2013
Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation M Suárez-Fariñas, R Arbeit, W Jiang, FS Ortenzio, T Sullivan, JG Krueger	PloS one	2013
RNA recognition by human TLR8 can lead to autoimmune inflammation C Guiducci, M Gong, AM Cepika, Z Xu, C Tripodo, L Bennett, C Crain, P Quartier, JJ Cush, V Pascual, RL Coffman, FJ Barrat	Journal of Experimental Medicine	2013
TLRs and interferons: a central paradigm in autoimmunity DH Kono, R Baccala, AN Theofilopoulos	Current Opinion in Immunology	2013
Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo SN Lauder, VJ Tyrrell, K Allen-Redpath, M Aldrovandi, D Gray, P Collins, SA Jones, PR Taylor, V O'Donnell	Wellcome Open Research	2013
Defense genes missing from the flight division KE Magor, DM Navarro, MR Barber, K Petkau, X Fleming-Canepa, GA Blyth, AH Blaine	Developmental and comparative immunology	2013
Spontaneous activation of RNA-sensing pathways in autoimmune disease Crampton SP, Bolland S	Current Opinion in Immunology	2013
Therapeutic Applications of Nucleic Acids and Their Analogues in Toll-like Receptor Signaling V Gosu, S Basith, OP Kwon, S Choi	Molecules (Basel, Switzerland)	2012
B-cell selection and the development of autoantibodies NV Giltiay, CP Chappell, EA Clark	Arthritis Research & Therapy	2012
Targeting pattern recognition receptors in cancer immunotherapy N Goutagny, Y Estornes, U Hasan, S Lebecque, C Caux	Targeted Oncology	2012
Placental Toll-Like Receptor 3 and Toll-Like Receptor 7/8 Activation Contributes to Preeclampsia in Humans and Mice P Chatterjee, LE Weaver, KM Doersch, SE Kopriva, VL Chiasson, SJ Allen, AM Narayanan, KJ Young, KA Jones, TJ Kuehl, BM Mitchell	PloS one	2012
Resurrection of endogenous retroviruses in antibody-deficient mice GR Young, U Eksmond, R Salcedo, L Alexopoulou, JP Stoye, G Kassiotis	Nature	2012
TLR8: the forgotten relative revindicated JL Cervantes, B Weinerman, C Basole, JC Salazar	Cellular and Molecular Immunology	2012
Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response CM Fang, S Roy, E Nielsen, M Paul, R Maul, A Paun, F Koentgen, FM Raval, E Szomolanyi-Tsuda, PM Pitha	Genes and Immunity	2012
Toll-like receptors in systemic lupus erythematosus: potential targets for therapeutic intervention CG Horton, AD Farris	Current Allergy and Asthma Reports	2012
The Therapeutic Potential of Toll-like Receptor 7 Stimulation in Asthma Drake MG, Kaufman EH, Fryer AD, Jacoby DB	Inflammation & allergy drug targets	2012
Protective T cell immunity in mice following protein-TLR7/8 agonist conjugate immunization requires aggregation, Type I IFN, and the conjoint function of multiple dendritic cell subsets Kathrin Kastenmueller, Ulrike Wille-Reece, Ross W.B. Lindsay, Lauren R. Trager, Patricia A. Darrah, Barbara J. Flynn, Maria R. Becker, Mark Udey, Björn Clausen, Botond Z. Igyarto, Daniel Kaplan, Wolfgang Kastenmuller, Ronald Germain, Robert A. Seder	Journal of Clinical Investigation	2011
Intracellular Nucleic Acid Sensors and Autoimmunity AN Theofilopoulos, DH Kono, B Beutler, R Baccala	Journal of Interferon & Cytokine Research	2011
Modulating Toll-like Receptor 7 and 9 Responses as Therapy for Allergy and Autoimmunity D Matesic, A Lenert, P Lenert	Current Allergy and Asthma Reports	2011
Toll-Like Receptor Agonists Synergize with CD40L to Induce Either Proliferation or Plasma Cell Differentiation of Mouse B Cells E Boeglin, CR Smulski, S Brun, S Milosevic, P Schneider, S Fournel	PloS one	2011
Toll-like receptor driven B cell activation in the induction of systemic autoimmunity NM Green, A Marshak-Rothstein	Seminars in Immunology	2011
Innate Immune sensing of DNA viruses VA Rathinam, KA Fitzgerald	Virology	2011
Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection N Gratz, H Hartweger, U Matt, F Kratochvill, M Janos, S Sigel, B Drobits, XD Li, S Knapp, P Kovarik	PLoS pathogens	2011
Poly-Thymidine Oligonucleotides Mediate Activation of Murine Glial Cells Primarily Through TLR7, Not TLR8 M Du, NB Butchi, T Woods, KE Peterson	PloS one	2011
TLR7 and TLR9 Trigger Distinct Neuroinflammatory Responses in the CNS NB Butchi, T Woods, M Du, TW Morgan, KE Peterson	The American Journal of Pathology	2011
Toll-like receptor 7 stimulation promotes autoimmune diabetes in the NOD mouse AS Lee, M Ghoreishi, WK Cheng, TY Chang, YQ Zhang, JP Dutz	Diabetologia	2011
New Insights into the Biology and Pathobiology of Beta2-Glycoprotein I B Giannakopoulos, P Mirarabshahi, SA Krilis	Current Rheumatology Reports	2010

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