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Citations to this article

Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress–specific manner
Kel Vin Woo, … , Sergio Fazio, H. Scott Baldwin
Kel Vin Woo, … , Sergio Fazio, H. Scott Baldwin
Published March 7, 2011
Citation Information: J Clin Invest. 2011;121(4):1624-1635. https://doi.org/10.1172/JCI42040.
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Research Article Cardiology Article has an altmetric score of 6

Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress–specific manner

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Abstract

Although the response of endothelial cells to the disturbed blood flow in the vicinity of atherosclerotic lesions is known to be distinct from that elicited by nonatherogenic laminar flow, the mechanisms involved are poorly understood. Our initial studies confirmed that expression of the endothelial receptor tyrosine kinase Tie1 was evident at regions of atherogenic flow in mature animals. We therefore hypothesized that Tie1 plays a role in the endothelial response to atherogenic shear stress. Consistent with this, we found that Tie1+/– mice bred to the apoE-deficient background displayed a 35% reduction in atherosclerosis relative to Tie1+/+;Apoe–/– mice. Since deletion of Tie1 results in embryonic lethality secondary to vascular dysfunction, we used conditional and inducible mutagenesis to study the effect of endothelial-specific Tie1 attenuation on atherogenesis in Apoe–/– mice and found a dose-dependent decrease in atherosclerotic lesions. Analysis of primary aortic endothelial cells indicated that atheroprotective laminar flow decreased Tie1 expression in vitro. Attenuation of Tie1 was associated with an increase in eNOS expression and Tie2 phosphorylation. In addition, Tie1 attenuation increased IkBα expression while decreasing ICAM levels. In summary, we have found that shear stress conditions that modulate atherogenic events also regulate Tie1 expression. Therefore, Tie1 may play a novel proinflammatory role in atherosclerosis.

Authors

Kel Vin Woo, Xianghu Qu, Vladimir R. Babaev, MacRae F. Linton, Raul J. Guzman, Sergio Fazio, H. Scott Baldwin

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Total
Citations: 1 2 5 4 3 3 4 3 4 5 5 3 1 1 1 45
Citation information
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Citations to this article (45)

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Journal of Clinical Investigation 2024
Mechanosensory entities and functionality of endothelial cells.
Mierke CT, Mierke CT
Frontiers in cell and developmental biology 2024
Vascular mechanotransduction
Davis MJ, Earley S, Li YS, Chien S
Physiological reviews 2023
FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma through TIE1-mediated PI3K/AKT signaling pathway
Chen E, Huang J, Chen M, Wu J, Ouyang P, Wang X, Shi D, Liu Z, Zhu W, Sun H, Yang S, Zhang B, Deng W, Qiu H, Xie F
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A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes.
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Cell reports. Medicine 2023
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Anisimov A, Fang S, Hemanthakumar KA, Örd T, van Avondt K, Chevre R, Toropainen A, Singha P, Gilani H, Nguyen SD, Karaman S, Korhonen EA, Adams RH, Augustin HG, Öörni K, Soehnlein O, Kaikkonen MU, Alitalo K
2023
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Elenbaas JS, Jung IH, Coler-Reilly A, Lee PC, Alisio A, Stitziel NO
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2022
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iScience 2019
Loss of flow responsive Tie1 results in Impaired Aortic valve remodeling
X Qu, K Violette, MK Sewell-Loftin, J Soslow, LS Saint-Jean, RB Hinton, WD Merryman, HS Baldwin
Developmental Biology 2019
Anti-angiogenic Targets: Angiopoietin and Angiopoietin Receptors
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Tumor Angiogenesis 2019
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Therapeutic targeting of the angiopoietin–TIE pathway
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