Go to
JCI Insight
Citations to this article
Jean-Emmanuel Sarry, … , G. Danet-Desnoyers, Martin Carroll
Published December 13, 2010
Citation Information: J Clin Invest. 2011;121(1):384-395. https://doi.org/10.1172/JCI41495.
Citation Information: J Clin Invest. 2011;121(1):384-395. https://doi.org/10.1172/JCI41495.
Abstract
Human leukemic stem cells, like other cancer stem cells, are hypothesized to be rare, capable of incomplete differentiation, and restricted to a phenotype associated with early hematopoietic progenitors or stem cells. However, recent work in other types of tumors has challenged the cancer stem cell model. Using a robust model of xenotransplantation based on NOD/SCID/IL2Rγc-deficient mice, we confirmed that human leukemic stem cells, functionally defined by us as SCID leukemia-initiating cells (SL-ICs), are rare in acute myelogenous leukemia (AML). In contrast to previous results, SL-ICs were found among cells expressing lineage markers (i.e., among Lin+ cells), CD38, or CD45RA, all markers associated with normal committed progenitors. Remarkably, each engrafting fraction consistently recapitulated the original phenotypic diversity of the primary AML specimen and contained self-renewing leukemic stem cells, as demonstrated by secondary transplants. While SL-ICs were enriched in the Lin–CD38– fraction compared with the other fractions analyzed, SL-ICs in this fraction represented only one-third of all SL-ICs present in the unfractionated specimen. These results indicate that human AML stem cells are rare and enriched but not restricted to the phenotype associated with normal primitive hematopoietic cells. These results suggest a plasticity of the cancer stem cell phenotype that we believe has not been previously described.
Authors
Jean-Emmanuel Sarry, Kathleen Murphy, Robin Perry, Patricia V. Sanchez, Anthony Secreto, Cathy Keefer, Cezary R. Swider, Anne-Claire Strzelecki, Cindy Cavelier, Christian Récher, Véronique Mansat-De Mas, Eric Delabesse, G. Danet-Desnoyers, Martin Carroll
Total citations by year
Citation information
Citations to this article (199)
| Title and authors | Publication | Year |
|---|---|---|
|
Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance
Takao S, Morell V, Uni M, Slavit A, Rha S, Cheng S, Schmalbrock LK, Brown FC, Beneyto-Calabuig S, Koche RP, Velten L, Kentsis A |
Nature Communications | 2025 |
|
Therapeutic Hurdles in Acute Myeloid Leukemia: Leukemic Stem Cells, Inflammation and Immune Dysfunction
Wang B, Reville PK, Abbas HA |
Current opinion in pharmacology | 2025 |
|
Integrative single‐cell expression and functional studies unravels a sensitization to cytarabine‐based chemotherapy through HIF pathway inhibition in AML leukemia stem cells
Velasco\u2010Hernandez T, Trincado JL, Vinyoles M, Closa A, Martínez\u2010Moreno A, Gutiérrez\u2010Agüera F, Molina O, Rodríguez\u2010Cortez VC, Ximeno\u2010Parpal P, Fernández\u2010Fuentes N, Petazzi P, Beneyto\u2010Calabuig S, Velten L, Romecin P, Casquero R, Abollo\u2010Jiménez F, de la Guardia RD, Lorden P, Bataller A, Lapillonne H, Stam RW, Vives S, Torrebadell M, Fuster JL, Bueno C, Sarry J, Eyras E, Heyn H, Menéndez P |
HemaSphere | 2024 |
|
Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction.
Ai CJ, Chen LJ, Guo LX, Wang YP, Zhao ZY |
World journal of stem cells | 2024 |
|
Imaging Flow Cytometry and Convolutional Neural Network-Based Classification Enable Discrimination of Hematopoietic and Leukemic Stem Cells in Acute Myeloid Leukemia
Hybel TE, Jensen SH, Rodrigues MA, Hybel TE, Pedersen MN, Qvick SH, Enemark MH, Bill M, Rosenberg CA, Ludvigsen M |
International journal of molecular sciences | 2024 |
|
RHOF activation of AKT/β-catenin signaling pathway drives acute myeloid leukemia progression and chemotherapy resistance
Wen X, Li P, Ma Y, Wang D, Jia R, Xia Y, Li W, Li Y, Li G, Sun T, Lu F, Ye J, Ji C |
iScience | 2024 |
|
Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems
Lee BC |
BMB Reports | 2024 |
|
Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML
Grenier JM, Testut C, Bal M, Bardin F, De Grandis M, Gelsi-Boyer V, Vernerey J, Delahaye M, Granjeaud S, Zemmour C, Spinella JF, Chavakis T, Mancini SJ, Boher JM, Hébert J, Sauvageau G, Vey N, Schwaller J, Hospital MA, Fauriat C, Aurrand-Lions M |
Blood Advances | 2024 |
|
Characterization of stem cell landscape and assessing the stemness degree to aid clinical therapeutics in hematologic malignancies.
Feng YD, Du J, Chen HL, Shen Y, Jia YC, Zhang PY, He A, Yang Y |
Scientific reports | 2024 |
|
The epigenetic state of the cell of origin defines mechanisms of leukemogenesis.
Li Z, Fierstein S, Tanaka-Yano M, Frenis K, Chen CC, Wang D, Falchetti M, Côté P, Curran C, Lu K, Liu T, Orkin S, Li H, Lummertz da Rocha E, Hu S, Zhu Q, Rowe RG |
Leukemia | 2024 |
|
The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development
Sturgeon CM, Wagenblast E, Izzo F, Papapetrou EP |
Blood Cancer Discovery | 2024 |
|
Immunophenotypic aberrant hematopoietic stem cells in myelodysplastic syndromes: a biomarker for leukemic progression.
van Spronsen MF, Hanekamp D, Westers TM, van Gils N, Vermue E, Rutten A, Jansen JH, Lissenberg-Witte BI, Smit L, Schuurhuis GJ, van de Loosdrecht AA |
Leukemia | 2023 |
|
Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells
van der Werf I, Mondala PK, Steel SK, Balaian L, Ladel L, Mason CN, Diep RH, Pham J, Cloos J, Kaspers GJ, Chan WC, Mark A, La Clair JJ, Wentworth P, Fisch KM, Crews LA, Whisenant TC, Burkart MD, Donohoe ME, Jamieson CH |
Cell reports. Medicine | 2023 |
|
Single-cell genomics in AML: extending the frontiers of AML research.
Ediriwickrema A, Gentles AJ, Majeti R |
Blood | 2023 |
|
Super-enhancer-associated gene CAPG promotes AML progression
Ma Q, Zhao M, Long B, Li H |
Communications biology | 2023 |
|
Fatty Acid Metabolites and the Tumor Microenvironment as Potent Regulators of Cancer Stem Cell Signaling
Murai T, Matsuda S |
Metabolites | 2023 |
|
Leukemic progenitor compartment serves as a prognostic measure of cancer stemness in patients with acute myeloid leukemia.
Boyd AL, Lu J, Hollands CG, Alsostovar L, Murali S, Reid JC, Ye W, Vandersluis S, Johnson P, ElRafie A, Porras DP, Xenocostas D, Leber A, Leber B, Foley R, Trus M, Berg T, Kawata E, Xenocostas A, Bhatia M |
Cell reports. Medicine | 2023 |
|
The Therapeutic Potential of a Strategy to Prevent Acute Myeloid Leukemia Stem Cell Reprogramming in Older Patients
Park MN |
International journal of molecular sciences | 2023 |
|
Bcl-2 inhibition combined with PPARα activation synergistically targets leukemic stem cell-like cells in acute myeloid leukemia.
Xie C, Zhou H, Qin D, Zheng H, Tang Y, Li W, Zhou J, Liu L, Yu X, Duan H, Zhou Y, Li Z, Fang Z, Luo Y, Carter BZ, Xu B, Zha J |
Cell Death and Disease | 2023 |
|
A novel type of monocytic leukemia stem cell revealed by the clinical use of venetoclax-based therapy
Pei S, Shelton IT, Gillen AE, Stevens BM, Gasparetto M, Wang Y, Liu L, Liu J, Brunetti TM, Engel K, Staggs S, Showers W, Sheth AI, Amaya ML, Minhajuddin M, Winters A, Patel SB, Tolison H, Krug AE, Young TN, Schowinsky J, McMahon CM, Smith CA, Pollyea DA, Jordan CT |
Cancer Discovery | 2023 |
|
Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia.
Murtadha M, Park M, Zhu Y, Caserta E, Dona AA, Singer M, Vahed H, Tasndoh T, Gonzalez A, Ly K, Sanchez JF, Chowdhury A, Pozhitkov A, Ghoda L, Li L, Zhang B, Krishnan A, Marcucci G, Williams J, Pichiorri F |
bioRxiv : the preprint server for biology | 2023 |
|
Emerging and Future Targeted Therapies for Pediatric Acute Myeloid Leukemia: Targeting the Leukemia Stem Cells.
Murphy LA, Winters AC |
Biomedicines | 2023 |
|
Precise single-cell transcriptomic mapping of normal and leukemic cell states reveals unconventional lineage priming in acute myeloid leukemia.
Zeng AGX, Iacobucci I, Shah S, Mitchell A, Wong G, Bansal S, Gao Q, Kim H, Kennedy JA, Minden MD, Haferlach T, Mullighan CG, Dick JE |
bioRxiv : the preprint server for biology | 2023 |
|
Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells
M Dupont, M Huart, C Lauvinerie, A Bidet, A Guitart, A Villacreces, I Vigon, V Desplat, A Habhab, A Pigneux, Z Ivanovic, P la Grange, P Dumas, J Pasquet |
Cancers | 2022 |
|
Human acute myeloid leukemia stem cells: evolution of concept
D Shin |
Blood Research | 2022 |
|
The role of serum amyloid A1 in the adipogenic differentiation of human adipose-derived stem cells basing on single-cell RNA sequencing analysis
Qu R, He K, Yang Y, Fan T, Sun B, Khan AU, Huang W, Ouyang J, Pan X, Dai J |
Stem Cell Research & Therapy | 2022 |
|
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
Morris V, Wang D, Li Z, Marion W, Hughes T, Sousa P, Harada T, Sui SH, Naumenko S, Kalfon J, Sensharma P, Falchetti M, da Silva RV, Candelli T, Schneider P, Margaritis T, Holstege FC, Pikman Y, Harris M, Stam RW, Orkin SH, Koehler AN, Shalek AK, North TE, Pimkin M, Daley GQ, da Rocha EL, Rowe RG |
Cell Reports | 2022 |
|
Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells
Niu J, Peng D, Liu L |
Frontiers in Oncology | 2022 |
|
Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia
Vergez F, Largeaud L, Bertoli S, Nicolau ML, Rieu JB, Vergnolle I, Saland E, Sarry A, Tavitian S, Huguet F, Picard M, Vial JP, Lechevalier N, Bidet A, Dumas PY, Pigneux A, Luquet I, Mansat-De Mas V, Delabesse E, Carroll M, Danet-Desnoyers G, Sarry JE, Récher C |
Blood Cancer Journal | 2022 |
|
Proteomic Profiling Identifies Specific Leukemic Stem Cell-Associated Protein Expression Patterns in Pediatric AML Patients.
Petersen MA, Rosenberg CA, Bill M, Enemark MB, Rahbek O, Roug AS, Hasle H, Honoré B, Ludvigsen M |
Cancers | 2022 |
|
Bone marrow stroma cells promote induction of a chemoresistant and prognostic unfavorable S100A8/A9high AML cell subset.
Böttcher M, Panagiotidis K, Bruns H, Stumpf M, Völkl S, Geyh S, Dietel B, Schroeder T, Mackensen A, Mougiakakos D |
Blood Advances | 2022 |
|
Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in DNMT3AmutNPM1mut AMLs
Donato E, Correia N, Andresen C, Karpova D, Würth R, Klein C, Sohn M, Przybylla A, Zeisberger P, Rothfelder K, Salih H, Bonig H, Stasik S, Röllig C, Dolnik A, Bullinger L, Buchholz F, Thiede C, Hübschmann D, Trumpp A |
Blood Advances | 2022 |
|
Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia
Yasuhiro Shingai, Takafumi Yokota, Daisuke Okuzaki, Takao Sudo, Tomohiko Ishibashi, Yukiko Doi, Tomoaki Ueda, Takayuki Ozawa, Ritsuko Nakai, Akira Tanimura, Michiko Ichii, Hirohiko Shibayama, Yuzuru Kanakura, Naoki Hosen |
Stem Cells | 2021 |
|
Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells
V Fregona, M Bayet, B Gerby |
Cancers | 2021 |
|
SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells
S Tahk, B Vick, B Hiller, S Schmitt, A Marcinek, ED Perini, A Leutbecher, C Augsberger, A Reischer, B Tast, A Humpe, I Jeremias, M Subklewe, NC Fenn, KP Hopfner |
Journal of Hematology & Oncology | 2021 |
|
Emerging Bone Marrow Microenvironment-Driven Mechanisms of Drug Resistance in Acute Myeloid Leukemia: Tangle or Chance?
M Ciciarello, G Corradi, D Forte, M Cavo, A Curti |
Cancers | 2021 |
|
Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia
N van Gils, F Denkers, L Smit |
Frontiers in Oncology | 2021 |
|
Roles Played by YY1 in Embryonic, Adult and Cancer Stem Cells
GU Martinez-Ruiz, A Morales-Sanchez, AF Pacheco-Hernandez |
Stem Cell Reviews and Reports | 2021 |
|
Stem cell origins of JMML
S Sundaravel, U Steidl |
Journal of Experimental Medicine | 2021 |
|
Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells
C Larrue, N Guiraud, PL Mouchel, M Dubois, T Farge, M Gotanègre, C Bosc, E Saland, ML Nicolau-Travers, M Sabatier, N Serhan, A Sahal, E Boet, S Mouche, Q Heydt, N Aroua, L Stuani, T Kaoma, L Angenendt, JH Mikesch, C Schliemann, F Vergez, J Tamburini, C Récher, JE Sarry |
Nature Communications | 2021 |
|
Immunosuppressive Cell Subsets and Factors in Myeloid Leukemias
J Swatler, L Turos-Korgul, E Kozlowska, K Piwocka |
Cancers | 2021 |
|
Platelet Microparticles Decrease Daunorubicin-Induced DNA Damage and Modulate Intrinsic Apoptosis in THP-1 Cells
D Cacic, O Nordgård, P Meyer, T Hervig |
International journal of molecular sciences | 2021 |
|
Platelet Microparticles Protect Acute Myelogenous Leukemia Cells against Daunorubicin-Induced Apoptosis
D Cacic, H Reikvam, O Nordgård, P Meyer, T Hervig |
Cancers | 2021 |
|
Targeted blockade of immune mechanisms inhibit B precursor acute lymphoblastic leukemia cell invasion of the central nervous system
Rajakumar SA, Grandal I, Minden MD, Hitzler JK, Guidos CJ, Danska JS |
Cell reports. Medicine | 2021 |
|
Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia
A Villatoro, J Konieczny, V Cuminetti, L Arranz |
Frontiers in Cell and Developmental Biology | 2020 |
|
Studying leukemia stem cell properties and vulnerabilities with human iPSCs
N Spyrou, EP Papapetrou |
Stem Cell Research | 2020 |
|
Expression of putative leukemia stem cell targets in genetically-defined acute myeloid leukemia subtypes
B Yanagisawa, B Perkins, T Karantanos, M Levis, G Ghiaur, BD Smith, RJ Jones |
Leukemia Research | 2020 |
|
Daratumumab inhibits acute myeloid leukaemia metabolic capacity by blocking mitochondrial transfer from mesenchymal stromal cells
JJ Mistry, JA Moore, P Kumar, CR Marlein, C Hellmich, G Pillinger, A Jibril, FD Palma, A Collins, KM Bowles, SA Rushworth |
Haematologica | 2020 |
|
Applicability and reproducibility of acute myeloid leukaemia stem cell assessment in a multi‐centre setting
D Hanekamp, AN Snel, A Kelder, WJ Scholten, N Khan, M Metzner, M IrnoConsalvo, M Sugita, A Jong, SO Alink, H Eidhof, M Wilhelm, M FeuringBuske, J Slomp, VH Velden, E Sonneveld, M Guzman, GJ Roboz, F Buccisano, P Vyas, S Freeman, C Bachas, GJ Ossenkoppele, GJ Schuurhuis, J Cloos |
British Journal of Haematology | 2020 |
|
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
V Barbier, J Erbani, C Fiveash, JM Davies, J Tay, MR Tallack, J Lowe, JL Magnani, DR Pattabiraman, AC Perkins, J Lisle, JE Rasko, JP Levesque, IG Winkler |
Nature Communications | 2020 |
|
CD200 expression marks leukemia stem cells in human AML
JM Ho, SM Dobson, V Voisin, J McLeod, JA Kennedy, A Mitchell, L Jin, K Eppert, G Bader, MD Minden, JE Dick, JC Wang |
Blood Advances | 2020 |
|
CD34+CD38−CD123+ Leukemic Stem Cell Frequency Predicts Outcome in Older Acute Myeloid Leukemia Patients Treated by Intensive Chemotherapy but Not Hypomethylating Agents
F Vergez, ML Nicolau-Travers, S Bertoli, JB Rieu, S Tavitian, P Bories, I Luquet, VD Mas, L Largeaud, A Sarry, F Huguet, E Delabesse, E Bérard, C Récher |
Cancers | 2020 |
|
Acute Myeloid Leukemia Stem Cells: The Challenges of Phenotypic Heterogeneity
M Arnone, M Konantz, P Hanns, AM Stanger, S Bertels, PS Godavarthy, M Christopeit, C Lengerke |
Cancers | 2020 |
|
Leukemia Stem Cells in Hematologic Malignancies
H Zhang, S Li |
2019 | |
|
Current Outlook on Autophagy in Human Leukemia: Foe in Cancer Stem Cells and Drug Resistance, Friend in New Therapeutic Interventions
K Rothe, V Porter, X Jiang |
International journal of molecular sciences | 2019 |
|
Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons from Current Approaches and Advances in the Leukemia Stem Cell (LSC) Model Can Inform Better Strategies for Treating Acute Myeloid Leukemia (AML)
K Mitchell, U Steidl |
Cold Spring Harbor Perspectives in Medicine | 2019 |
|
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
Y Song, A Rongvaux, A Taylor, T Jiang, T Tebaldi, K Balasubramanian, A Bagale, YK Terzi, R Gbyli, X Wang, X Fu, Y Gao, J Zhao, N Podoltsev, M Xu, N Neparidze, E Wong, R Torres, EM Bruscia, Y Kluger, MG Manz, RA Flavell, S Halene |
Nature Communications | 2019 |
|
Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
J Paris, M Morgan, J Campos, GJ Spencer, A Shmakova, I Ivanova, C Mapperley, H Lawson, DA Wotherspoon, C Sepulveda, M Vukovic, L Allen, A Sarapuu, A Tavosanis, AV Guitart, A Villacreces, C Much, J Choe, A Azar, LN van de Lagemaat, D Vernimmen, A Nehme, F Mazurier, TC Somervaille, RI Gregory, D OCarroll, KR Kranc |
Cell Stem Cell | 2019 |
|
Mutations associated with a 17-gene leukemia stem cell score and the score’s prognostic relevance in the context of the European LeukemiaNet classification of acute myeloid leukemia
M Bill, D Nicolet, J Kohlschmidt, CJ Walker, K Mrózek, AK Eisfeld, D Papaioannou, X Rong-Mullins, Z Brannan, JE Kolitz, BL Powell, KJ Archer, AM Dorrance, AJ Carroll, RM Stone, JC Byrd, R Garzon, CD Bloomfield |
Haematologica | 2019 |
|
Mesenchymal stromal cells confer chemoresistance to myeloid leukemia blasts through Side Population functionality and ABC transporter activation
L Boutin, P Arnautou, A Trignol, A Ségot, T Farge, C Desterke, S Soave, D Clay, E Raffoux, JE Sarry, JV Malfuson, JJ Lataillade, MC Bousse-Kerdilès, A Anginot |
Haematologica | 2019 |
|
The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia
C Annageldiyev, K Gowda, T Patel, P Bhattacharya, SF Tan, S Iyer, D Desai, S Dovat, DJ Feith, TP Loughran, S Amin, D Claxton, A Sharma |
Haematologica | 2019 |
|
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
S Pei, M Minhajuddin, B Adane, N Khan, BM Stevens, SC Mack, S Lai, JN Rich, A Inguva, KM Shannon, H Kim, AC Tan, JR Myers, JM Ashton, T Neff, DA Pollyea, CA Smith, CT Jordan |
Cell Stem Cell | 2018 |
|
Animal models for bone tissue engineering and modelling disease
JA McGovern, M Griffin, DW Hutmacher |
Disease models & mechanisms | 2018 |
|
Murine models based on acute myeloid leukemia-initiating stem cells xenografting
C Mambet, M Chivu-Economescu, L Matei, LG Necula, DL Dragu, C Bleotu, CC Diaconu |
World journal of stem cells | 2018 |
|
The rocky road to personalized medicine in acute myeloid leukaemia
B Brinda, I Khan, B Parkin, H Konig |
Journal of Cellular and Molecular Medicine | 2018 |
|
IL1RAP potentiates multiple oncogenic signaling pathways in AML
K Mitchell, L Barreyro, TI Todorova, SJ Taylor, I Antony-Debré, SR Narayanagari, LA Carvajal, J Leite, Z Piperdi, G Pendurti, I Mantzaris, E Paietta, A Verma, K Gritsman, U Steidl |
Journal of Experimental Medicine | 2018 |
|
Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2
C O'Connor, K Yalla, M Salomé, HA Moka, EG Castañeda, PA Eyers, K Keeshan |
Oncotarget | 2018 |
|
Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells
M Krevvata, X Shan, C Zhou, CD Santos, GH Ndikuyeze, A Secreto, J Glover, W Trotman, G Brake-Silla, S Nunez-Cruz, G Wertheim, HJ Ra, E Griffiths, C Papachristou, G Danet-Desnoyers, M Carroll |
Haematologica | 2018 |
|
Leukemia reconstitution in vivo is driven by cells in early cell cycle and low metabolic state
L Trentin, M Queudeville, SM Eckhoff, N Hasan, V Münch, E Boldrin, F Seyfried, S Enzenmüller, KM Debatin, LH Meyer |
Haematologica | 2018 |
|
Acute myeloid leukemia xenograft success prediction: Saving time
E Griessinger, J Vargaftig, S Horswell, DC Taussig, J Gribben, D Bonnet |
Experimental Hematology | 2018 |
|
Synthesis and biological evaluation of dithiocarbamate esters of parthenolide as potential anti-acute myelogenous leukaemia agents
Y Ding, Z Yang, W Ge, B Kuang, J Xu, J Yang, Y Chen, Q Zhang |
Journal of Enzyme Inhibition and Medicinal Chemistry | 2018 |
|
Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia
DA Pollyea, BM Stevens, CL Jones, A Winters, S Pei, M Minhajuddin, A DAlessandro, R Culp-Hill, KA Riemondy, AE Gillen, JR Hesselberth, D Abbott, D Schatz, JA Gutman, E Purev, C Smith, CT Jordan |
Nature Medicine | 2018 |
|
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells
CL Jones, BM Stevens, A D'Alessandro, JA Reisz, R Culp-Hill, T Nemkov, S Pei, N Khan, B Adane, H Ye, A Krug, D Reinhold, C Smith, J DeGregori, DA Pollyea, CT Jordan |
Cancer Cell | 2018 |
|
Identification of functionally primitive and immunophenotypically distinct subpopulations in secondary acute myeloid leukemia by mass cytometry: SECONDARY AML POPULATION IDENTIFIED BY MASS CYTOMETRY
S Bandyopadhyay, JS Fowles, L Yu, DA Fisher, ST Oh |
Cytometry. Part B, Clinical cytometry | 2018 |
|
Expression of CD25 fluctuates in the leukemia-initiating cell population of CD25-positive AML
Y Kageyama, H Miwa, R Arakawa, I Tawara, K Ohishi, M Masuya, K Nakase, N Katayama, F Bertolini |
PloS one | 2018 |
|
In quest for leukemia initiating cells in AML
De Grandis M, Mancini SJ, Aurrand-Lions M |
Oncoscience | 2018 |
|
Personalized medicine-guided synthetic lethality eradicates proliferating and quiescent leukemia cells
Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Grazyna Hoser, Silvia Maifrede, Esteban Martinez, Daniela Di Marcantonio, Elisabeth Bolton, Kimberly Cramer, Jae-Woong Lee, Sierra Min Li, Artur Slupianek, Daniel Gritsyuk, Sabine Cerny-Reiterer, Ilona Seferynska, Tomasz Stoklosa, Lars Bullinger, Huaqing Zhao, vera gorbunova, Katarzyna Piwocka, Peter Valent, Curt Civin, Markus Müschen, John E. Dick, Jean C.Y. Wang, Smita Bhatia, Ravi Bhatia, Kolja Eppert, Mark D. Minden, Stephen Sykes, Tomasz Skorski |
Journal of Clinical Investigation | 2017 |
|
Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia
SH Tan, FC Bertulfo, T Sanda |
Frontiers in Oncology | 2017 |
|
Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
T Farge, E Saland, F Toni, N Aroua, M Hosseini, R Perry, C Bosc, M Sugita, L Stuani, M Fraisse, S Scotland, C Larrue, H Boutzen, V Féliu, ML Nicolau-Travers, S Cassant-Sourdy, N Broin, M David, N Serhan, A Sarry, S Tavitian, T Kaoma, L Vallar, J Iacovoni, LK Linares, C Montersino, R Castellano, E Griessinger, Y Collette, O Duchamp, Y Barreira, P Hirsch, T Palama, L Gales, F Delhommeau, BH Garmy-Susini, JC Portais, F Vergez, M Selak, G Danet-Desnoyers, M Carroll, C Récher, JE Sarry |
Cancer Discovery | 2017 |
|
Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera
T Tsuruta-Kishino, J Koya, K Kataoka, K Narukawa, Y Sumitomo, H Kobayashi, T Sato, M Kurokawa |
Oncogene | 2017 |
|
Understanding of leukemic stem cells and their clinical implications
X Wang, S Huang, JL Chen |
Molecular Cancer | 2017 |
|
Targeting acute myeloid leukemia stem cell signaling by natural products
KS Siveen, S Uddin, RM Mohammad |
Molecular Cancer | 2017 |
|
Leukemic stem cells: identification and clinical application
D Hanekamp, J Cloos, GJ Schuurhuis |
International Journal of Hematology | 2017 |
|
Biology and relevance of human acute myeloid leukemia stem cells
D Thomas, R Majeti |
Blood | 2017 |
|
Live kinase B1 maintains CD34+CD38− AML cell proliferation and self-renewal
H Wang, X Wang, N Xin, L Qi, A Liao, W Yang, Z Liu, C Zhao |
Molecular and Cellular Biochemistry | 2017 |
|
Modeling the process of human tumorigenesis
S Balani, LV Nguyen, CJ Eaves |
Nature Communications | 2017 |
|
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
LP Vu, BF Pickering, Y Cheng, S Zaccara, D Nguyen, G Minuesa, T Chou, A Chow, Y Saletore, M MacKay, J Schulman, C Famulare, M Patel, VM Klimek, FE Garrett-Bakelman, A Melnick, M Carroll, CE Mason, SR Jaffrey, MG Kharas |
Nature Medicine | 2017 |
|
Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice
A Reinisch, DC Hernandez, K Schallmoser, R Majeti |
Nature Protocols | 2017 |
|
An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia
Z Her, KS Yong, K Paramasivam, WW Tan, XY Chan, SY Tan, M Liu, Y Fan, YC Linn, KM Hui, U Surana, Q Chen |
Journal of Hematology & Oncology | 2017 |
|
Phenotypic heterogeneity in modeling cancer evolution
A Mahdipour-Shirayeh, K Kaveh, M Kohandel, S Sivaloganathan, AB Hjelmeland |
PloS one | 2017 |
|
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
S Raffel, M Falcone, N Kneisel, J Hansson, W Wang, C Lutz, L Bullinger, G Poschet, Y Nonnenmacher, A Barnert, C Bahr, P Zeisberger, A Przybylla, M Sohn, M Tönjes, A Erez, L Adler, P Jensen, C Scholl, S Fröhling, S Cocciardi, P Wuchter, C Thiede, A Flörcken, J Westermann, G Ehninger, P Lichter, K Hiller, R Hell, C Herrmann, AD Ho, J Krijgsveld, B Radlwimmer, A Trumpp |
Nature | 2017 |
|
[The study of expression and prognostic value of CD123 in acute myeloid leukemia bone marrow blasts]
W Q Yue, G S Tang, M Liu, H Cheng, J Ding, T Wang, J M Wang, X X Hu, W P Zhang, L Chen, J M Yang |
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi | 2017 |
|
Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche
H Ye, B Adane, N Khan, T Sullivan, M Minhajuddin, M Gasparetto, B Stevens, S Pei, M Balys, JM Ashton, DJ Klemm, CM Woolthuis, AW Stranahan, CY Park, CT Jordan |
Cell Stem Cell | 2016 |
|
Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?
L Pleyer, P Valent, R Greil |
International journal of molecular sciences | 2016 |
|
Rational Design of a Parthenolide-based Drug Regimen that Selectively Eradicates Acute Myelogenous Leukemia Stem Cells
S Pei, M Minhajuddin, A D'Alessandro, T Nemkov, BM Stevens, B Adane, N Khan, FK Hagen, VK Yadav, S De, JM Ashton, KC Hansen, JA Gutman, DA Pollyea, PA Crooks, C Smith, CT Jordan |
The Journal of biological chemistry | 2016 |
|
Antigen expression on a putative leukemic stem cell population and AML blast
S Garg, K Ghosh, M Madkaikar |
International Journal of Hematology | 2016 |
|
A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells
A Reinisch, D Thomas, MR Corces, X Zhang, D Gratzinger, WJ Hong, K Schallmoser, D Strunk, R Majeti |
Nature Medicine | 2016 |
|
Genetically distinct leukemic stem cells in human CD34 − acute myeloid leukemia are arrested at a hemopoietic precursor-like stage
L Quek, GW Otto, C Garnett, L Lhermitte, D Karamitros, B Stoilova, IJ Lau, J Doondeea, B Usukhbayar, A Kennedy, M Metzner, N Goardon, A Ivey, C Allen, R Gale, B Davies, A Sternberg, S Killick, H Hunter, P Cahalin, A Price, A Carr, M Griffiths, P Virgo, S Mackinnon, D Grimwade, S Freeman, N Russell, C Craddock, A Mead, A Peniket, C Porcher, P Vyas |
Journal of Experimental Medicine | 2016 |
|
KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells
J Etchin, A Berezovskaya, AS Conway, IA Galinsky, RM Stone, E Baloglu, W Senapedis, Y Landesman, M Kauffman, S Shacham, JC Wang, AT Look |
Leukemia | 2016 |
|
Evolution of acute myelogenous leukemia stem cell properties after treatment and progression
TC Ho, M LaMere, BM Stevens, JM Ashton, JR Myers, KM ODwyer, JL Liesveld, JH Mendler, M Guzman, JD Morrissette, J Zhao, ES Wang, M Wetzler, CT Jordan, MW Becker |
Blood | 2016 |
|
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity
BA Jonas, C Johnson, D Gratzinger, R Majeti, CJ Eaves |
PloS one | 2016 |
|
High-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy
PB Ferrell, KE Diggins, HG Polikowsky, SR Mohan, AC Seegmiller, JM Irish, K Metze |
PloS one | 2016 |
|
Association of acute myeloid leukemias most immature phenotype with risk groups and outcomes
JM Gerber, JF Zeidner, S Morse, AL Blackford, B Perkins, B Yanagisawa, H Zhang, L Morsberger, J Karp, Y Ning, CD Gocke, GL Rosner, BD Smith, RJ Jones |
Haematologica | 2016 |
|
Liquid-based three-dimensional tumor models for cancer research and drug discovery
SL Ham, R Joshi, PS Thakuri, H Tavana |
Experimental biology and medicine (Maywood, N.J.) | 2016 |
|
All-trans retinoic acid enhances cytotoxic effect of T cells with an anti-CD38 chimeric antigen receptor in acute myeloid leukemia
T Yoshida, K Mihara, Y Takei, K Yanagihara, T Kubo, J Bhattacharyya, C Imai, T Mino, Y Takihara, T Ichinohe |
IBMS BoneKEy | 2016 |
|
CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia
C Riether, CM Schürch, ED Bührer, M Hinterbrandner, AL Huguenin, S Hoepner, I Zlobec, T Pabst, R Radpour, AF Ochsenbein |
Journal of Experimental Medicine | 2016 |
|
Translating leukemia stem cells into the clinical setting: Harmonizing the heterogeneity
B Yanagisawa, G Ghiaur, BD Smith, RJ Jones |
Experimental Hematology | 2016 |
|
A 17-gene stemness score for rapid determination of risk in acute leukaemia
SW Ng, A Mitchell, JA Kennedy, WC Chen, J McLeod, N Ibrahimova, A Arruda, A Popescu, V Gupta, AD Schimmer, AC Schuh, KW Yee, L Bullinger, T Herold, D Görlich, T Büchner, W Hiddemann, WE Berdel, B Wörmann, M Cheok, C Preudhomme, H Dombret, K Metzeler, C Buske, B Löwenberg, PJ Valk, PW Zandstra, MD Minden, JE Dick, JC Wang |
Nature | 2016 |
|
Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia
N Khan, RK Hills, S Knapper, L Steadman, U Qureshi, JL Rector, C Bradbury, NH Russell, P Vyas, AK Burnett, D Grimwade, PS Hole, SD Freeman, F Bertolini |
PloS one | 2016 |
|
Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality
M Dimitriou, PS Woll, T Mortera-Blanco, M Karimi, DC Wedge, H Doolittle, I Douagi, E Papaemmanuil, SE Jacobsen, E Hellström-Lindberg |
Oncotarget | 2016 |
|
Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1
NH Darwish, T Sudha, K Godugu, O Elbaz, HA Abdelghaffar, EE Hassan, SA Mousa |
Oncotarget | 2016 |
|
A gene-expression profile for leukaemia
GJ Schuurhuis |
Nature | 2016 |
|
Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells
X Liu, X Chen, K Rycaj, HP Chao, Q Deng, C Jeter, C Liu, S Honorio, H Li, T Davis, M Suraneni, B Laffin, J Qin, Q Li, T Yang, P Whitney, J Shen, J Huang, DG Tang |
Oncotarget | 2015 |
|
Targeting leukemia stem cells in vivo with antagomiR-126 nanoparticles in acute myeloid leukemia
AM Dorrance, P Neviani, GJ Ferenchak, X Huang, D Nicolet, KS Maharry, HG Ozer, P Hoellarbauer, J Khalife, EB Hill, M Yadav, BN Bolon, RJ Lee, LJ Lee, CM Croce, R Garzon, MA Caligiuri, CD Bloomfield, G Marcucci |
Leukemia | 2015 |
|
Targeted therapy against cancer stem cells (Review)
T Yang, K Rycaj |
Oncology Letters | 2015 |
|
Mouse models for core binding factor leukemia
DW Chin, N Watanabe-Okochi, CQ Wang, V Tergaonkar, M Osato |
Leukemia | 2015 |
|
IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells
C Schinke, O Giricz, W Li, A Shastri, S Gordon, L Barreryo, T Bhagat, S Bhattacharyya, N Ramachandra, M Bartenstein, A Pellagatti, J Boultwood, A Wickrema, Y Yu, B Will, S Wei, U Steidl, A Verma |
Blood | 2015 |
|
Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?
A Schulenburg, K Blatt, S Cerny-Reiterer, I Sadovnik, H Herrmann, B Marian, TW Grunt, CC Zielinski, P Valent |
Journal of Hematology & Oncology | 2015 |
|
An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis
N Jung, B Dai, AJ Gentles, R Majeti, AP Feinberg |
Nature Communications | 2015 |
|
Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells
S Ito, AJ Barrett, A Dutra, E Pak, S Miner, K Keyvanfar, NF Hensel, K Rezvani, P Muranski, P Liu, JJ Melenhorst, A Larochelle |
Stem Cell Research | 2015 |
|
A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia
E Saland, H Boutzen, R Castellano, L Pouyet, E Griessinger, C Larrue, F Toni, S Scotland, M David, G Danet-Desnoyers, F Vergez, Y Barreira, Y Collette, C Récher, JE Sarry |
Blood Cancer Journal | 2015 |
|
An Advanced Preclinical Mouse Model for Acute Myeloid Leukemia Using Patients' Cells of Various Genetic Subgroups and In Vivo Bioluminescence Imaging
B Vick, M Rothenberg, N Sandhöfer, M Carlet, C Finkenzeller, C Krupka, M Grunert, A Trumpp, S Corbacioglu, M Ebinger, MC André, W Hiddemann, S Schneider, M Subklewe, KH Metzeler, K Spiekermann, I Jeremias, PD Sbarba |
PloS one | 2015 |
|
Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia
AH Shih, Y Jiang, C Meydan, K Shank, S Pandey, L Barreyro, I Antony-Debre, A Viale, N Socci, Y Sun, A Robertson, M Cavatore, E de Stanchina, T Hricik, F Rapaport, B Woods, C Wei, M Hatlen, M Baljevic, SD Nimer, M Tallman, E Paietta, L Cimmino, I Aifantis, U Steidl, C Mason, A Melnick, RL Levine |
Cancer Cell | 2015 |
|
Understanding melanoma stem cells
N Nguyen, KL Couts, Y Luo, M Fujita |
Melanoma Management | 2015 |
|
PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome
A Pandolfi, RF Stanley, Y Yu, B Bartholdy, G Pendurti, K Gritsman, J Boultwood, J Chernoff, A Verma, U Steidl |
Blood | 2015 |
|
Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice
J Etchin, J Montero, A Berezovskaya, BT Le, A Kentsis, AL Christie, AS Conway, WC Chen, C Reed, MR Mansour, CE Ng, S Adamia, SJ Rodig, IA Galinsky, RM Stone, B Klebanov, Y Landesman, M Kauffman, S Shacham, AL Kung, JC Wang, A Letai, AT Look |
Leukemia | 2015 |
|
The novel function of CD82 and its impact on BCL2L12 via AKT/STAT5 signal pathway in acute myelogenous leukemia cells
C Nishioka, T Ikezoe, A Takeuchi, A Nobumoto, M Tsuda, A Yokoyama |
Leukemia | 2015 |
|
A simple one-tube assay for immunophenotypical quantification of leukemic stem cells in acute myeloid leukemia
W Zeijlemaker, A Kelder, YJ Oussoren-Brockhoff, WJ Scholten, AN Snel, D Veldhuizen, J Cloos, GJ Ossenkoppele, GJ Schuurhuis |
Leukemia | 2015 |
|
Understanding leukemic hematopoiesis as a complex adaptive system
Xavier Thomas |
World journal of stem cells | 2015 |
|
Mass Cytometric Functional Profiling of Acute Myeloid Leukemia Defines Cell-Cycle and Immunophenotypic Properties That Correlate with Known Responses to Therapy
GK Behbehani, N Samusik, ZB Bjornson, WJ Fantl, BC Medeiros, GP Nolan |
Cancer Discovery | 2015 |
|
The rarity of ALDH + cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients: Aldehyde dehydrogenase in acute myeloid leukemia
VT Hoang, EC Buss, W Wang, I Hoffmann, S Raffel, A Zepeda-Moreno, N Baran, P Wuchter, V Eckstein, A Trumpp, A Jauch, AD Ho, C Lutz |
International Journal of Cancer | 2015 |
|
Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells
A Reinisch, SM Chan, D Thomas, R Majeti |
Seminars in Hematology | 2015 |
|
[Development of immunodeficient mice/humanized mouse models and their applications in hematology research]
Yawei Zheng, Sha Hao, Linping Hu, Tao Cheng |
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi | 2015 |
|
Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation
Han S, Guo J, Liu Y, Zhang Z, He Q, Li P, Zhang M, Sun H, Li R, Li Y, Zeng W, Liu J, Lian L, Gao Y, Shen L |
Oncotarget | 2015 |
|
NF-kB/TNF-a positive feedback loop supports myeloid leukemia initiating cell capacity
Yuki Kagoya, Akihide Yoshimi, Keisuke Kataoka, Masahiro Nakagawa, Keiki Kumano, Shunya Arai, Hiroshi Kobayashi, Taku Saito, Yoichiro Iwakura, Mineo Kurokawa |
Journal of Clinical Investigation | 2014 |
|
Can systems biology approach help in finding more effective treatment for acute myeloid leukemia?
A Vaidya |
Systems and synthetic biology | 2014 |
|
A Niche-Like Culture System Allowing the Maintenance of Primary Human Acute Myeloid Leukemia-Initiating Cells: A New Tool to Decipher Their Chemoresistance and Self-Renewal Mechanisms
E Griessinger, F Anjos-Afonso, I Pizzitola, K Rouault-Pierre, J Vargaftig, D Taussig, J Gribben, F Lassailly, D Bonnet |
Stem Cells Translational Medicine | 2014 |
|
The mammary cellular hierarchy and breast cancer
SR Oakes, D Gallego-Ortega, CJ Ormandy |
Cellular and Molecular Life Sciences | 2014 |
|
Kinase-Independent Mechanisms of Resistance of Leukemia Stem Cells to Tyrosine Kinase Inhibitors
CV Ichim |
Stem Cells Translational Medicine | 2014 |
|
Human Cancer Growth and Therapy in Immunodeficient Mouse Models
LD Shultz, N Goodwin, F Ishikawa, V Hosur, BL Lyons, DL Greiner |
Cold Spring Harbor Protocols | 2014 |
|
Leukemia stem cells: Old concepts and new perspectives
SA Mariani, B Calabretta |
Molecular Aspects of Medicine | 2014 |
|
Genetic barcode sequencing for screening altered population dynamics of hematopoietic stem cells transduced with lentivirus
DB Zanatta, M Tsujita, P Borelli, RB Aguiar, DG Ferrari, BE Strauss |
Molecular Therapy — Methods & Clinical Development | 2014 |
|
Cancer Stem Cells: Constantly Evolving and Functionally Heterogeneous Therapeutic Targets
T Yang, K Rycaj, ZM Liu, DG Tang |
Cancer research | 2014 |
|
Functional integration of acute myeloid leukemia into the vascular niche
CR Cogle, DC Goldman, GJ Madlambayan, RP Leon, AA Masri, HA Clark, SA Asbaghi, JW Tyner, J Dunlap, G Fan, T Kovacsovics, Q Liu, A Meacham, KL Hamlin, RA Hromas, EW Scott, WH Fleming |
Leukemia Supplements | 2014 |
|
Heterogeneity of clonal expansion and maturation-linked mutation acquisition in hematopoietic progenitors in human acute myeloid leukemia
RB Walter, GS Laszlo, JM Lionberger, JA Pollard, KH Harrington, CJ Gudgeon, M Othus, S Rafii, S Meshinchi, FR Appelbaum, ID Bernstein |
Leukemia | 2014 |
|
Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
JM Klco, DH Spencer, CA Miller, M Griffith, TL Lamprecht, M O’Laughlin, C Fronick, V Magrini, RT Demeter, RS Fulton, WC Eades, DC Link, TA Graubert, MJ Walter, ER Mardis, JF Dipersio, RK Wilson, TJ Ley |
Cancer Cell | 2014 |
|
It takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brain
DH Janssens, CY Lee |
Seminars in Cell & Developmental Biology | 2014 |
|
Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells
AM Cook, L Li, Y Ho, A Lin, L Li, A Stein, S Forman, D Perrotti, R Jove, R Bhatia |
Blood | 2014 |
|
A Phase 2 study of bortezomib combined with either idarubicin/cytarabine or cytarabine/etoposide in children with relapsed, refractory or secondary acute myeloid leukemia: A report from the Children's Oncology Group: Bortezomib With Reinduction in Pediatric AML
TM Horton, JP Perentesis, AS Gamis, TA Alonzo, RB Gerbing, J Ballard, K Adlard, DS Howard, FO Smith, G Jenkins, A Kelder, GJ Schuurhuis, JA Moscow |
Pediatric Blood & Cancer | 2014 |
|
Regulation of hematopoietic and leukemic stem cells by the immune system
C Riether, CM Schürch, AF Ochsenbein |
Cell Death and Differentiation | 2014 |
|
Targeting acute myeloid leukemia stem cells: a review and principles for the development of clinical trials
DA Pollyea, JA Gutman, L Gore, CA Smith, CT Jordan |
Haematologica | 2014 |
|
Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia
J Zhou |
World journal of stem cells | 2014 |
|
Prognostic value of monitoring a candidate immunophenotypic leukaemic stem/progenitor cell population in patients allografted for acute myeloid leukaemia
C Bradbury, AE Houlton, S Akiki, R Gregg, M Rindl, J Khan, J Ward, N Khan, M Griffiths, S Nagra, R Hills, A Burnett, N Russell, P Vyas, D Grimwade, C Craddock, SD Freeman |
Leukemia | 2014 |
|
Leukemic Stem Cell Frequency: A Strong Biomarker for Clinical Outcome in Acute Myeloid Leukemia
Monique Terwijn, Wendelien Zeijlemaker, Angèle Kelder, Arjo P. Rutten, Alexander N. Snel, Willemijn J. Scholten, Thomas Pabst, Gregor Verhoef, Bob Löwenberg, Sonja Zweegman, Gert J. Ossenkoppele, Gerrit J. Schuurhuis |
PloS one | 2014 |
|
Engraftment of Human Primary Acute Myeloid Leukemia Defined by Integrated Genetic Profiling in NOD/SCID/IL2rγnull Mice for Preclinical Ceramide-Based Therapeutic Evaluation
NR Keasey |
Journal of Leukemia | 2014 |
|
MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells
D Stroopinsky, J Rosenblatt, K Ito, H Mills, L Yin, H Rajabi, B Vasir, T Kufe, K Luptakova, J Arnason, C Nardella, JD Levine, RM Joyce, I Galinsky, Y Reiter, RM Stone, PP Pandolfi, D Kufe, D Avigan |
Cancer research | 2013 |
|
The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents
CD Santos, T McDonald, YW Ho, H Liu, A Lin, SJ Forman, YH Kuo, R Bhatia |
Blood | 2013 |
|
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells
S Pei, M Minhajuddin, KP Callahan, M Balys, JM Ashton, SJ Neering, ED Lagadinou, C Corbett, H Ye, JL Liesveld, KM O'Dwyer, Z Li, L Shi, P Greninger, J Settleman, C Benes, FK Hagen, J Munger, PA Crooks, MW Becker, CT Jordan |
The Journal of biological chemistry | 2013 |
|
Dendritic Cell-Based Immunotherapy for Myeloid Leukemias
CM Schürch, C Riether, AF Ochsenbein |
Frontiers in immunology | 2013 |
|
Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells
A Pandolfi, L Barreyro, U Steidl |
Stem Cells Translational Medicine | 2013 |
|
Tumour heterogeneity and cancer cell plasticity
CE Meacham, SJ Morrison |
Nature | 2013 |
|
BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
ED Lagadinou, A Sach, K Callahan, RM Rossi, SJ Neering, M Minhajuddin, JM Ashton, S Pei, V Grose, KM O’Dwyer, JL Liesveld, PS Brookes, MW Becker, CT Jordan |
Cell Stem Cell | 2013 |
|
AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model
M Wunderlich, B Mizukawa, FS Chou, C Sexton, M Shrestha, Y Saunthararajah, JC Mulloy |
Blood | 2013 |
|
A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia
KH Metzeler, K Maharry, J Kohlschmidt, S Volinia, K Mrózek, H Becker, D Nicolet, SP Whitman, JH Mendler, S Schwind, AK Eisfeld, YZ Wu, BL Powell, TH Carter, M Wetzler, JE Kolitz, MR Baer, AJ Carroll, RM Stone, MA Caligiuri, G Marcucci, CD Bloomfield |
Leukemia | 2013 |
|
Delineating MEIS1 cis-regulatory elements active in hematopoietic cells
P Xiang, W Wei, C Lo, P Rosten, J Hou, PA Hoodless, M Bilenky, C Bonifer, PN Cockerill, A Kirkpatrick, B Gottgens, M Hirst, KR Humphries |
Leukemia | 2013 |
|
Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia
H Zhang, M Alberich-Jorda, G Amabile, H Yang, PB Staber, AD Ruscio, RS Welner, A Ebralidze, J Zhang, E Levantini, V Lefebvre, PJ Valk, R Delwel, M Hoogenkamp, C Nerlov, J Cammenga, B Saez, DT Scadden, C Bonifer, M Ye, DG Tenen |
Cancer Cell | 2013 |
|
The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts
J Zabkiewicz, L Pearn, RK Hills, RG Morgan, A Tonks, AK Burnett, RL Darley |
Haematologica | 2013 |
|
Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation
KP Ng, Z Hu, Q Ebrahem, S Negrotto, J Lausen, Y Saunthararajah |
Oncogenesis | 2013 |
|
A new inducible model for t(8;21) AML
JC Mulloy |
EMBO Molecular Medicine | 2013 |
|
A possible explanation for the variable frequencies of cancer stem cells in tumors
RV Santos, LM da Silva |
PloS one | 2013 |
|
Optimization of cytarabine (ARA-C) therapy for acute myeloid leukemia
RL Momparler |
Experimental Hematology and Oncology | 2013 |
|
In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemia in NSG mice
M Bonin, M Wermke, KN Cosgun, C Thiede, M Bornhauser, G Wagemaker, C Waskow |
PloS one | 2013 |
|
Spleens of Myelofibrosis Patients Contain Malignant Hematopoietic Stem Cells
Xiaoli Wang, Sonam Prakash, Min Lu, Joseph Tripodi, Fei Ye, Vesna Najfeld, Yan Li, Myron Schwartz, Rona Weinberg, Paul Roda, Attilio Orazi, Ronald Hoffman |
Journal of Clinical Investigation | 2012 |
|
The hematopoietic stem cell niche--home for friend and foe?
DS Krause, DT Scadden, FI Preffer |
Cytometry. Part B, Clinical cytometry | 2012 |
|
Decoupling of Tumor-Initiating Activity from Stable Immunophenotype in HoxA9-Meis1-Driven AML
KD Gibbs, A Jager, O Crespo, Y Goltsev, A Trejo, CE Richard, GP Nolan |
Cell Stem Cell | 2012 |
|
Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS
L Barreyro, B Will, B Bartholdy, L Zhou, TI Todorova, RF Stanley, S Ben-Neriah, C Montagna, S Parekh, A Pellagatti, J Boultwood, E Paietta, RP Ketterling, L Cripe, HF Fernandez, PL Greenberg, MS Tallman, C Steidl, CS Mitsiades, A Verma, U Steidl |
Blood | 2012 |
|
p53-Independent, Normal Stem Cell Sparing Epigenetic Differentiation Therapy for Myeloid and Other Malignancies
Y Saunthararajah, P Triozzi, B Rini, A Singh, T Radivoyevitch, M Sekeres, A Advani, R Tiu, F Reu, M Kalaycio, E Copelan, E Hsi, A Lichtin, B Bolwell |
Seminars in Oncology | 2012 |
|
Understanding cancer stem cell heterogeneity and plasticity
DG Tang |
Cell Research | 2012 |
|
Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia
B Zhang, YW Ho, Q Huang, T Maeda, A Lin, S Lee, A Hair, TL Holyoake, C Huettner, R Bhatia |
Cancer Cell | 2012 |
|
An evolutionary explanation for the presence of cancer nonstem cells in neoplasms
K Sprouffske, CA Aktipis, JP Radich, M Carroll, AM Nedelcu, CC Maley |
Evolutionary Applications | 2012 |
|
Targeting Myelogenous Leukemia Stem Cells: Role of the Circulation
J Liesveld |
Frontiers in Oncology | 2012 |
|
Cancer as a moving target: understanding the composition and rebound growth kinetics of recurrent tumors
J Foo, K Leder, SM Mumenthaler |
Evolutionary Applications | 2012 |
|
Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia
B Parkin, P Ouillette, Y Li, J Keller, C Lam, D Roulston, C Li, K Shedden, SN Malek |
Blood | 2012 |
|
Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
JA Magee, E Piskounova, SJ Morrison |
Cancer Cell | 2012 |
|
Cancer stem cells: relevance to clinical transplantation
G Ghiaur, JM Gerber, W Matsui, RJ Jones |
Current Opinion in Oncology | 2012 |
|
Cancer stem cells as 'units of selection'
M Greaves |
Evolutionary Applications | 2012 |
|
A clinically relevant population of leukemic CD34(+)CD38(-) cells in acute myeloid leukemia
JM Gerber, BD Smith, B Ngwang, H Zhang, MS Vala, L Morsberger, S Galkin, MI Collector, B Perkins, MJ Levis, CA Griffin, SJ Sharkis, MJ Borowitz, JE Karp, RJ Jones |
Blood | 2012 |
|
Cell Plasticity and Heterogeneity in Cancer
ND Marjanovic, RA Weinberg, CL Chaffer |
Clinical chemistry | 2012 |
|
Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)
Herrmann H, Blatt K, Shi J, Gleixner KV, Cerny-Reiterer S, Müllauer L, Vakoc CR, Sperr WR, Horny HP, Bradner JE, Zuber J, Valent P |
Oncotarget | 2012 |
|
From Cancer Stem Cells to Tumor Maintenance in Melanoma
M Fukunaga-Kalabis, A Roesch, M Herlyn |
Journal of Investigative Dermatology | 2011 |
|
Frequency of leukemic initiating cells does not depend on the xenotransplantation model used
J Vargaftig, DC Taussig, E Griessinger, F Anjos-Afonso, TA Lister, J Cavenagh, H Oakervee, J Gribben, D Bonnet |
Leukemia | 2011 |
|
Cancer stem cell hypotheses: Impact on modern molecular physiology and pharmacology research
I Pantic |
Journal of Biosciences | 2011 |
|
Concise Review: Cancer Stem Cells and Minimal Residual Disease
G Ghiaur, J Gerber, RJ Jones |
Stem Cells | 2011 |
|
CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors
S Negrotto, KP Ng, AM Jankowska, J Bodo, B Gopalan, K Guinta, JC Mulloy, E Hsi, J Maciejewski, Y Saunthararajah |
Leukemia | 2011 |
|
High levels of CD34+CD38low/−CD123+ blasts are predictive of an adverse outcome in acute myeloid leukemia: a Groupe Ouest-Est des Leucémies Aiguës et Maladies du Sang (GOELAMS) study
F Vergez, AS Green, J Tamburini, JE Sarry, B Gaillard, P Cornillet-Lefebvre, M Pannetier, A Neyret, N Chapuis, N Ifrah, F Dreyfus, S Manenti, C Demur, E Delabesse, C Lacombe, P Mayeux, D Bouscary, C Recher, V Bardet |
Haematologica | 2011 |
|
Epithelial to Mesenchymal Transition by TGFβ-1 Induction Increases Stemness Characteristics in Primary Non Small Cell Lung Cancer Cell Line
G Pirozzi, V Tirino, R Camerlingo, R Franco, AL Rocca, E Liguori, N Martucci, F Paino, N Normanno, G Rocco |
PloS one | 2011 |
|
Stem cell gene expression programs influence clinical outcome in human leukemia
K Eppert, K Takenaka, ER Lechman, L Waldron, B Nilsson, P van Galen, KH Metzeler, A Poeppl, V Ling, J Beyene, AJ Canty, JS Danska, SK Bohlander, C Buske, MD Minden, TR Golub, I Jurisica, BL Ebert, JE Dick |
Nature Medicine | 2011 |
|
Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience
LaRochelle O, Bertoli S, Vergez F, Sarry JE, Mansat-De Mas V, Dobbelstein S, Dastugue N, Strzelecki AC, Cavelier C, Creancier L, Pillon A, Kruczynski A, Demur C, Sarry A, Huguet F, Huynh A, Récher C, Delabesse E |
Oncotarget | 2011 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)