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Uterine disorders and pregnancy complications: insights from mouse models
Hyunjung Jade Lim, Haibin Wang
Hyunjung Jade Lim, Haibin Wang
Published April 1, 2010
Citation Information: J Clin Invest. 2010;120(4):1004-1015. https://doi.org/10.1172/JCI41210.
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Uterine disorders and pregnancy complications: insights from mouse models

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Abstract

Much of our knowledge of human uterine physiology and pathology has been extrapolated from the study of diverse animal models, as there is no ideal system for studying human uterine biology in vitro. Although it remains debatable whether mouse models are the most suitable system for investigating human uterine function(s), gene-manipulated mice are considered by many the most useful tool for mechanistic analysis, and numerous studies have identified many similarities in female reproduction between the two species. This Review brings together information from studies using animal models, in particular mouse models, that shed light on normal and pathologic aspects of uterine biology and pregnancy complications.

Authors

Hyunjung Jade Lim, Haibin Wang

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Figure 3

Decidualization and placentation in mice.

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Decidualization and placentation in mice.
Schematic diagrams depicting c...
Schematic diagrams depicting cross-sections of implantation sites on days 4, 7, and 13 of pregnancy. (A) On day 4, the luminal epithelium closes on an implanting blastocyst. The mural trophectoderm, which is distant from the inner cell mass, contacts the epithelium at the antimesometrial side (AM). The decidual response also starts from the antimesometrial side (not shown). M, mesometrial side. (B) On day 7, the embryo is much larger, and its ectoplacental cone has penetrated the mesometrial decidua, which is enriched with blood vessels. Differentiated decidual cells now take up most of the implantation site (IS). Note that decidualization does not occur at inter-implantation sites. (C) On day 13, the placenta has developed, and the decidua has regressed to thin layers around the placenta and embryo, known as decidua basalis and decidua capsularis, respectively.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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