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Citations to this article

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Marc Foretz, … , Fabrizio Andreelli, Benoit Viollet
Marc Foretz, … , Fabrizio Andreelli, Benoit Viollet
Published June 23, 2010
Citation Information: J Clin Invest. 2010;120(7):2355-2369. https://doi.org/10.1172/JCI40671.
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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

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Abstract

Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metformin on hepatic gluconeogenesis. However, the molecular mechanism by which this pathway operates had remained elusive. Surprisingly, here we have found that in mice lacking AMPK in the liver, blood glucose levels were comparable to those in wild-type mice, and the hypoglycemic effect of metformin was maintained. Hepatocytes lacking AMPK displayed normal glucose production and gluconeogenic gene expression compared with wild-type hepatocytes. In contrast, gluconeogenesis was upregulated in LKB1-deficient hepatocytes. Metformin decreased expression of the gene encoding the catalytic subunit of glucose-6-phosphatase (G6Pase), while cytosolic phosphoenolpyruvate carboxykinase (Pepck) gene expression was unaffected in wild-type, AMPK-deficient, and LKB1-deficient hepatocytes. Surprisingly, metformin-induced inhibition of glucose production was amplified in both AMPK- and LKB1-deficient compared with wild-type hepatocytes. This inhibition correlated in a dose-dependent manner with a reduction in intracellular ATP content, which is crucial for glucose production. Moreover, metformin-induced inhibition of glucose production was preserved under forced expression of gluconeogenic genes through PPARγ coactivator 1α (PGC-1α) overexpression, indicating that metformin suppresses gluconeogenesis via a transcription-independent process. In conclusion, we demonstrate that metformin inhibits hepatic gluconeogenesis in an LKB1- and AMPK-independent manner via a decrease in hepatic energy state.

Authors

Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet

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Barrios-Bernal P, Zatarain-Barrón ZL, Hernández-Pedro N, Orozco-Morales M, Olivera-Ramírez A, Ávila-Moreno F, Colín-González AL, Cardona AF, Rosell R, Arrieta O
Pharmaceuticals 2022
Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders
Li N, Zhou T, Fei E
International journal of molecular sciences 2022
The effects of metformin in the treatment of osteoarthritis: Current perspectives
Song Y, Wu Z, Zhao P
Frontiers in pharmacology 2022
Sensing local energetics to acutely regulate mitophagy in skeletal muscle
Nichenko AS, Specht KS, Craige SM, Drake JC
Frontiers in Cell and Developmental Biology 2022
Physiological Systems in Promoting Frailty
Perazza LR, Brown-Borg HM, Thompson LV
Comprehensive Physiology 2022
The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis
Xu Y, Zheng S, Jiang S, Chen J, Zhu X, Zhang Y
Frontiers in Endocrinology 2022
IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway
Wang SX, Feng YN, Feng S, Wu JM, Zhang M, Xu WL, Zhang YY, Zhu HB, Xiao H, Dong ED
Acta Pharmacologica Sinica 2022
PF‐06409577 inhibits renal cyst progression by concurrently inhibiting the mTOR pathway and CFTR channel activity
Su L, Yuan H, Zhang H, Wang R, Fu K, Yin L, Ren Y, Liu H, Fang Q, Wang J, Guo D
FEBS Open Bio 2022
Multi-omics analysis reveals the pathogenesis of db/db mice diabetic kidney disease and the treatment mechanisms of multi-bioactive compounds combination from Salvia miltiorrhiza
Xu Z, Xiang X, Su S, Zhu Y, Yan H, Guo S, Guo J, Shang EX, Qian D, Duan JA
Frontiers in pharmacology 2022
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC
Nature metabolism 2022
Metformin Treatment Modulates Long Non-Coding RNA Isoforms Expression in Human Cells.
Conceição IMCAD, Luscher-Dias T, Queiroz LR, de Melo AGB, Machado CR, Gomes KB, Souza RP, Luizon MR, Franco GR
Non-Coding RNA 2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes
Chan LE, Casiraghi E, Laraway B, Coleman B, Blau H, Zaman A, Harris NL, Wilkins K, Antony B, Gargano M, Valentini G, Sahner D, Haendel M, Robinson PN, Bramante C, Reese J
Diabetes Research and Clinical Practice 2022
Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk
Lan WH, Lin TY, Yeh JA, Feng CL, Hsu JT, Lin HJ, Kuo CJ, Lai CH
International journal of molecular sciences 2022
Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
Du Y, Zhu YJ, Zhou YX, Ding J, Liu JY
2022
Artificial neural network applied to fragile X-associated tremor/ataxia syndrome stage diagnosis based on peripheral mitochondrial bioenergetics and brain imaging outcomes.
Giulivi C, Wang JY, Hagerman RJ
Scientific Reports 2022
AMPK integrates metabolite and kinase-based immunometabolic control in macrophages
Phair IR, Nisr RB, Howden AJ, Sovakova M, Alqurashi N, Foretz M, Lamont D, Viollet B, Rena G
Molecular Metabolism 2022
Kinase perturbations redirect mitochondrial function in cancer.
Torres-Quesada O, Strich S, Stefan E
2022
Metformin is Associated with Reduced COVID-19 Severity in Patients with Prediabetes
Chan LE, Casiraghi E, Laraway B, Coleman B, Blau H, Zaman A, Harris N, Wilkins K, Gargano M, Valentini G, Sahner D, Haendel M, Robinson PN, Bramante C, Reese J
2022
WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models
Takahiro Kishikawa, Hiroshi Higuchi, Limei Wang, Nivedita Panch, Valerie Maymi, Sachem Best, Samuel Lee, Genso Notoya, Alex Toker, Lydia E Matesic, Gerburg M. Wulf, Wenyi Wei, Motoyuki Otsuka, Kazuhiko Koike, John G. Clohessy, Yu-Ru Lee, Pier Paolo Pandolfi
Journal of Clinical Investigation 2021
AMPK induces regulatory innate lymphoid cells after traumatic brain injury
Babak Baban, Molly Braun, Hesam Khodadadi, Ayobami L. Ward, Katelyn Alverson, Aneeq Malik, Khoi D Nguyen, Skon Nazarian, David C. Hess, Scott Forseen, Alexander F Post, Fernando L Vale, John R Vender, Md Nasrul Hoda, Omid Akbari, Kumar Vaibhav, Krishnan M Dhandapani
JCI Insight 2021
Lessons from Cancer Metabolism for Pulmonary Arterial Hypertension and Fibrosis
SH Han, NS Chandel
American journal of respiratory cell and molecular biology 2021
New Aspects of Diabetes Research and Therapeutic Development
LS Satin, SA Soleimanpour, EM Walker, L Isom
Pharmacological reviews 2021
Metformin Targets Foxo1 to Control Glucose Homeostasis
X Guo, X Li, W Yang, W Liao, JZ Shen, W Ai, Q Pan, Y Sun, K Zhang, R Zhang, Y Qiu, Q Dai, H Zheng, S Guo
Biomolecules 2021
A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan
I Mohammed, MD Hollenberg, H Ding, CR Triggle
Frontiers in Endocrinology 2021
Metformin and Cancer Glucose Metabolism: At the Bench or at the Bedside?
C Marini, V Cossu, M Bauckneht, F Lanfranchi, S Raffa, AM Orengo, S Ravera, S Bruno, G Sambuceti
Biomolecules 2021
Prevention of Hypertensive Disorders of Pregnancy—Is There a Place for Metformin?
E Poniedziałek-Czajkowska, R Mierzyński, D Dłuski, B Leszczyńska-Gorzelak
Journal of Clinical Medicine 2021
Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers
P Kasper, S Breuer, T Hoffmann, C Vohlen, R Janoschek, L Schmitz, S Appel, G Fink, C Hünseler, A Quaas, M Demir, S Lang, HM Steffen, A Martin, C Schramm, M Bürger, E Mahabir, T Goeser, J Dötsch, E Hucklenbruch-Rother, I Bae-Gartz
Cells 2021
Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus
MP Sajan, BC Hansen, M AcevedoDuncan, MS Kindy, DR Cooper, RV Farese
2021
A spotlight on underlying the mechanism of AMPK in diabetes complications
T Behl, A Gupta, A Sehgal, S Sharma, S Singh, N Sharma, CC Diaconu, A Rahdar, A Hafeez, S Bhatia, A Al-Harrasi, S Bungau
Inflammation Research 2021
The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus
CB Lee, SU Chae, SJ Jo, UM Jerng, SK Bae
International journal of molecular sciences 2021
The Current and Potential Therapeutic Use of Metformin—The Good Old Drug
J Drzewoski, M Hanefeld
Pharmaceuticals (Basel, Switzerland) 2021
Metformin Decreases 2-HG Production through the MYC-PHGDH Pathway in Suppressing Breast Cancer Cell Proliferation
S Oh, Y Cho, M Chang, S Park, H Kwon
Metabolites 2021
LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases
Y Zhang, Q Meng, Q Sun, ZX Xu, H Zhou, Y Wang
Molecular Metabolism 2021
Roles of AMPK and Its Downstream Signals in Pain Regulation
S Wang, Y Dai
Life Sciences 2021
Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
B Zhou, Y Zhang, S Li, L Wu, G Fejes-Toth, A Naray-Fejes-Toth, AA Soukas
Cell Reports 2021
Incretin Hormones: Pathophysiological Risk Factors and Potential Targets for Type 2 Diabetes
J Rosenberg, J Jacob, P Desai, J Park, L Donovan, JY Kim
Journal of Obesity & Metabolic Syndrome 2021
Therapeutic Applications of Type 2 Diabetes Mellitus Drug Metformin in Patients with Osteoarthritis
P Song, JS Hwang, HC Park, KK Kim, HJ Son, YJ Kim, KM Lee
Pharmaceuticals (Basel, Switzerland) 2021
Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes
M Nishida, N Yamashita, T Ogawa, K Koseki, E Warabi, T Ohue, M Komatsu, H Matsushita, K Kakimi, E Kawakami, K Shiroguchi, H Udono
Journal for ImmunoTherapy of Cancer 2021
Nuts and bolts of the salt-inducible kinases (SIKs)
NJ Darling, P Cohen
Biochemical Journal 2021
Metformin: review of epidemiology and mechanisms of action in pancreatic cancer
G Eibl, E Rozengurt
Cancer and Metastasis Reviews 2021
Targeting the Apoa1 locus for liver-directed gene therapy
MD Giorgi, A Li, A Hurley, M Barzi, AM Doerfler, NA Cherayil, HE Smith, JD Brown, CY Lin, KD Bissig, G Bao, WR Lagor
Molecular Therapy — Methods & Clinical Development 2021
In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood
MC Faure, R Khoueiry, J Quanico, H Acloque, MJ Guerquin, MJ Bertoldo, C Chevaleyre, C Ramé, I Fournier, M Salzet, J Dupont, P Froment
Frontiers in Endocrinology 2021
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
D Višnjić, H Lalić, V Dembitz, B Tomić, T Smoljo
Cells 2021
Effects of Miao sour soup on hyperlipidemia in high‐fat diet‐induced obese rats via the AMPK signaling pathway
H Yang, J Xie, N Wang, Q Zhou, Y Lu, Z Qu, H Wang
Food Science & Nutrition 2021
Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way
W Guo, J Liu, L Cheng, Z Liu, X Zheng, H Liang, F Xu
Frontiers in pharmacology 2021
Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms
AO Shpakov
Pharmaceuticals (Basel, Switzerland) 2021
Metformin, Macrophage Dysfunction and Atherosclerosis
X Feng, W Chen, X Ni, PJ Little, S Xu, L Tang, J Weng
Frontiers in immunology 2021
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
D Ahwazi, K Neopane, GR Markby, F Kopietz, AJ Ovens, M Dall, AS Hassing, P Gräsle, Y Alshuweishi, JT Treebak, IP Salt, O Göransson, E Zeqiraj, JW Scott, K Sakamoto
Biochemical Journal 2021
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle
P Rhein, EM Desjardins, P Rong, D Ahwazi, N Bonhoure, J Stolte, MD Santos, AJ Ovens, AM Ehrlich, JL Garcia, Q Ouyang, JM Yabut, M Kjolby, M Membrez, N Jessen, JS Oakhill, JT Treebak, P Maire, JW Scott, MJ Sanders, P Descombes, S Chen, GR Steinberg, K Sakamoto
Molecular Metabolism 2021
Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis
SJ Park, F Ahmad, RJ Bahde, A Philp, J Kim, T Huang, MK Kim, WC Trenkle, JH Chung, P Song
PloS one 2021
miR-378a-3p Participates in Metformin’s Mechanism of Action on C2C12 Cells under Hyperglycemia
IF Machado, JS Teodoro, AC Castela, CM Palmeira, AP Rolo
International journal of molecular sciences 2021
Metformin - its anti-cancer effects in hematologic malignancies
M Podhorecka
Oncology Reviews 2021
Biphasic effect of metformin on human cardiac energetics
L Emelyanova, X Bai, Y Yan, ZJ Bosnjak, D Kress, C Warner, S Kroboth, T Rudic, S Kaushik, E Stoeckl, GR Ross, F Rizvi, AJ Tajik, A Jahangir
Translational research : the journal of laboratory and clinical medicine 2021
Drug Repurposing, an Attractive Strategy in Pancreatic Cancer Treatment: Preclinical and Clinical Updates
LD Lellis, S Veschi, N Tinari, Z Mokini, S Carradori, D Brocco, R Florio, A Grassadonia, A Cama
Cancers 2021
Efficacy and safety of metformin in the treatment of gestational diabetes: A protocol for systematic review and meta-analysis
W Mao, S Zhang, L Wang, S Shen
Medicine 2021
P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice
T Dusabimana, EJ Park, J Je, K Jeong, SP Yun, HJ Kim, H Kim, SW Park
International journal of molecular sciences 2021
Ameliorating Metabolic Profiles After Kidney Transplantation: A Protocol for an Open-Label, Prospective, Randomized, 3-Arm, Controlled Trial
S Yin, M Ma, Z Huang, Y Fan, X Wang, T Song, T Lin
Frontiers in Medicine 2021
Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area
G Tulipano
International journal of molecular sciences 2021
MicroRNA-185-5p inhibits hepatic gluconeogenesis and reduces fasting blood glucose levels by suppressing G6Pase
H Zheng, J Wan, Y Shan, , J Jin, Q Su, S Chen, X Lu, J Yang, Q Li, Y Song, B Li
Theranostics 2021
miR1908-5p regulates energy homeostasis in hepatocyte models
S Soubeyrand, P Lau, K Beehler, K McShane, R McPherson
Scientific Reports 2021
Metformin improves skeletal muscle microvascular insulin resistance in metabolic syndrome.
Jahn LA, Hartline L, Liu Z, Barrett EJ
American journal of physiology. Endocrinology and metabolism 2021
The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKα.
Dou X, Zhou WY, Ding M, Ma YJ, Yang QQ, Qian SW, Tang Y, Tang QQ, Liu Y
The Journal of biological chemistry 2021
Effect of linagliptin on glucose metabolism and pancreatic beta cell function in patients with persistent prediabetes after metformin and lifestyle.
Alvarez-Canales MFL, Salazar-López SS, Farfán-Vázquez D, Martínez-López YE, González-Mena JN, Jiménez-Ceja LM, Vargas-Ortiz K, Evia-Viscarra ML, Montes de Oca-Loyola ML, Folli F, Aguilar-García A, Guardado-Mendoza R
Scientific Reports 2021
Metformin and arsenic trioxide synergize to trigger Parkin/pink1-dependent mitophagic cell death in human cervical cancer HeLa cells.
Chen J, Zhou C, Yi J, Sun J, Xie B, Zhang Z, Wang Q, Chen G, Jin S, Hou J, Qin M, Wang L, Wei H
Journal of Cancer 2021
Metformin and its therapeutic applications in autoimmune inflammatory rheumatic disease
Kim JW, Choe JY, Park SH
The Korean Journal of Internal Medicine 2021
EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance
Ghoshal K, Li X, Peng D, Falck JR, Anugu RR, Chiusa M, Stafford JM, Wasserman DH, Zent R, Luther JM, Pozzi A
Diabetes 2021
KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver
AK Wara, S Wang, C Wu, F Fang, S Haemmig, BN Weber, CO Aydogan, Y Tesmenitsky, H Aliakbarian, JR Hawse, M Subramaniam, L Zhao, PT Sage, A Tavakkoli, A Garza, L Lynch, AS Banks, MW Feinberg
Cell Reports 2020
Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase
A Seneviratne, L Cave, G Hyde, SK Moestrup, D Carling, JC Mason, DO Haskard, JJ Boyle
Cardiovascular Research 2020
Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma
B Li, P Zhou, K Xu, T Chen, J Jiao, H Wei, X Yang, W Xu, W Wan, J Xiao
International journal of biological sciences 2020
Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
T Moonira, SS Chachra, BE Ford, S Marin, A Alshawi, NS Adam-Primus, C Arden, ZH Al-Oanzi, M Foretz, B Viollet, M Cascante, L Agius
The Journal of biological chemistry 2020
Metabolic Pathways in Alloreactive T Cells
RA Brown, CA Byersdorfer
Frontiers in immunology 2020
Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?
T Salvatore, PC Pafundi, R Galiero, L Rinaldi, A Caturano, E Vetrano, C Aprea, G Albanese, AD Martino, C Ricozzi, S Imbriani, FC Sasso
Biomedicines 2020
Metformin Protects against Podocyte Injury in Diabetic Kidney Disease
S Lehtonen
Pharmaceuticals (Basel, Switzerland) 2020
Cellular and Molecular Mechanisms of Metformin Action
TE LaMoia, GI Shulman
Endocrine reviews 2020
Metformin and Its Benefits for Various Diseases
Z Lv, Y Guo
Frontiers in Endocrinology 2020
Significance of Metformin Use in Diabetic Kidney Disease
D Kawanami, Y Takashi, M Tanabe
International journal of molecular sciences 2020
The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production
H An, Y Wang, C Qin, M Li, A Maheshwari, L He
Scientific Reports 2020
Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells
HS Kim, G Ren, T Kim, S Bhatnagar, Q Yang, YY Bahk, J Kim
Scientific Reports 2020
Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2
J Gao, J Yuan, Q Wang, T Lei, X Shen, B Cui, F Zhang, W Ding, Z Lu
Redox Biology 2020
Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection
DM Dunn, J Munger
Frontiers in Cellular and Infection Microbiology 2020
Impaired nicotinamide adenine dinucleotide (NAD + ) metabolism in diabetes and diabetic tissues: Implications for nicotinamide‐related compound treatment
L Fan, JM Cacicedo, Y Ido
Journal of Diabetes Investigation 2020
AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?
FM Russell, DG Hardie
International journal of molecular sciences 2020
Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents
C Huet, N Boudaba, B Guigas, B Viollet, M Foretz
The Journal of biological chemistry 2020
PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging
JJ Petrocelli, MJ Drummond
International journal of environmental research and public health 2020
Targeting immunometabolism as an anti-inflammatory strategy
EM Pålsson-McDermott, LA ONeill
Cell Research 2020
Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions
N Apostolova, F Iannantuoni, A Gruevska, J Muntane, M Rocha, VM Victor
Redox Biology 2020
AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP‐170
S Yashirogi, T Nagao, Y Nishida, Y Takahashi, T Qaqorh, I Yazawa, T Katayama, H Kioka, TS Matsui, S Saito, Y Masumura, O Tsukamoto, H Kato, H Ueda, O Yamaguchi, K Yashiro, S Yamazaki, S Takashima, Y Shintani
EMBO reports 2020
Strategies of Unloading the Failing Heart from Metabolic Stress
E Koutroumpakis, B Jozwik, D Aguilar, H Taegtmeyer
The American Journal of Medicine 2020
An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming
H Wang, X Wan, PF Pilch, LW Ellisen, SK Fried, L Liu
eLife 2020
Metformin and cognition from the perspectives of sex, age, and disease
K Chaudhari, CD Reynolds, SH Yang
GeroScience 2020
The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
L Agius, BE Ford, SS Chachra
International journal of molecular sciences 2020
Cancer Biology and Prevention in Diabetes
SP Srivastava, JE Goodwin
Cells 2020
Metformin May Contribute to Inter-individual Variability for Glycemic Responses to Exercise
SK Malin, NR Stewart
Frontiers in Endocrinology 2020
Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
PA Just, S Charawi, RG Denis, M Savall, M Traore, M Foretz, S Bastu, S Magassa, N Senni, P Sohier, M Wursmer, M Vasseur-Cognet, A Schmitt, ML Gall, M Leduc, F Guillonneau, JP Bandt, P Mayeux, B Romagnolo, S Luquet, P Bossard, C Perret
Nature Communications 2020
Metformin: A Prospective Alternative for the Treatment of Chronic Pain
GD Baeza-Flores, CG Guzmán-Priego, LI Parra-Flores, J Murbartián, JE Torres-López, V Granados-Soto
Frontiers in pharmacology 2020
Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response
M Ustinova, L Ansone, I Silamikelis, V Rovite, I Elbere, L Silamikele, I Kalnina, D Fridmanis, J Sokolovska, I Konrade, V Pirags, J Klovins, T Huang
PloS one 2020
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
N Oshima, R Ishida, S Kishimoto, K Beebe, JR Brender, K Yamamoto, D Urban, G Rai, MS Johnson, G Benavides, GL Squadrito, D Crooks, J Jackson, A Joshi, BT Mott, JH Shrimp, MA Moses, MJ Lee, A Yuno, TD Lee, X Hu, T Anderson, D Kusewitt, HH Hathaway, A Jadhav, D Picard, JB Trepel, JB Mitchell, GM Stott, W Moore, A Simeonov, LA Sklar, JP Norenberg, WM Linehan, DJ Maloney, CV Dang, AG Waterson, M Hall, VM Darley-Usmar, MC Krishna, LM Neckers
Cell Reports 2020
Metformin and Systemic Metabolism
L He
Trends in Pharmacological Sciences 2020
Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation
C Wang, T Zhang, Q Liao, M Dai, J Guo, X Yang, W Tan, D Lin, C Wu, Y Zhao
Protein & Cell 2020
BRAF Controls the Effects of Metformin on Neuroblast Cell Divisions in C. elegans
Z Qu, S Ji, S Zheng
International journal of molecular sciences 2020
Metformin enhances protection in guinea pigs chronically infected with Mycobacterium tuberculosis
JD Frenkel, DF Ackart, AK Todd, JE DiLisio, S Hoffman, S Tanner, D Kiran, M Murray, A Chicco, A Obregón-Henao, BK Podell, RJ Basaraba
Scientific Reports 2020
Metformin sensitizes therapeutic agents and improves outcome in pre-clinical and clinical diffuse large B-cell lymphoma
AR Singh, JJ Gu, Q Zhang, P Torka, S Sundaram, C Mavis, FJ Hernandez-Ilizaliturri
Cancer & Metabolism 2020

Guidelines and Considerations for Metabolic Tolerance Tests in Mice


R Benedé-Ubieto, O Estévez-Vázquez, P Ramadori, FJ Cubero, YA Nevzorova
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway
MA Najar, DA Rex, PK Modi, N Agarwal, S Dagamajalu, G Karthikkeyan, M Vijayakumar, A Chatterjee, U Sankar, TS Prasad
Journal of Cell Communication and Signaling 2020
Benefits of Metformin in Attenuating the Hallmarks of Aging
AS Kulkarni, S Gubbi, N Barzilai
Cell Metabolism 2020
Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice
Y Zhong, J Jin, P Liu, Y Song, H Zhang, L Sheng, H Zhou, B Jiang
Oxidative medicine and cellular longevity 2020
Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression
B Garzel, T Hu, L Li, Y Lu, S Heyward, J Polli, L Zhang, SM Huang, JP Raufman, H Wang
Pharmaceutical Research 2020
Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons
WB Chen, J Chen, ZY Liu, B Luo, T Zhou, EK Fei
Brain Sciences 2020
Exercise-Pharmacology Interactions: Metformin, Statins, and Healthspan
BF Miller, JP Thyfault
Physiology (Bethesda, Md.) 2020
Antidiabetic Effect of Artemether in Db/Db Mice Involves Regulation of AMPK and PI3K/Akt Pathways
X Bai, R Pei, W Lei, M Zhao, J Zhang, L Tian, J Shang
Frontiers in Endocrinology 2020

Effects of Metformin on the Gut Microbiota in Obesity and Type 2 Diabetes Mellitus


Q Zhang, N Hu
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020
Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system
S Demaré, A Kothari, NA Calcutt, P Fernyhough
Expert Review of Neurotherapeutics 2020
A Protocol for the Study of Polymorphisms and Response to Metformin in Patients with Type 2 Diabetes in Trinidad.
Clement Y, Singh S, Motilal S, Maharaj R, Nunez-Smith M
Ethnicity & disease 2020
Metformin attenuates steroidogenesis in ovarian follicles of the broiler breeder hen.
Weaver EA, Ramachandran R
Reproduction (Cambridge, England) 2020
Exercise and metformin counteract altered mitochondrial function in the insulin resistant brain
Gregory N Ruegsegger, Patrick Vanderboom, Surendra Dasari, Katherine Klaus, Parijat Kabiraj, Christina McCarthy, Claudia Lucchinetti, K Sreekumaran Nair
JCI Insight 2019
Targeting liver stage malaria with metformin
Iset Medina Vera, Margarida T. G. Ruivo, Leonardo F. Lemos Rocha, Sofia Marques, Sangeeta Bhatia, Maria M. Mota, Liliana Mancio-Silva
JCI Insight 2019
SHIPping out diabetes—Metformin, an old friend among new SHIP2 inhibitors
S Lehtonen
Acta physiologica (Oxford, England) 2019
SGLT2 inhibitors and metformin: Dual antihyperglycemic therapy and the risk of metabolic acidosis in type 2 diabetes
K Donnan, L Segar
European Journal of Pharmacology 2019
Unraveling the Regulation of Hepatic Gluconeogenesis
X Zhang, S Yang, J Chen, Z Su
Frontiers in Endocrinology 2019
Metformin: Mechanisms in Human Obesity and Weight Loss
A Yerevanian, AA Soukas
Current Obesity Reports 2019
The therapeutic potential of metformin in gastric cancer
S Courtois, P Lehours, E Bessède
Gastric Cancer 2019
Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation
D Vara-Ciruelos, M Dandapani, FM Russell, KM Grzes, A Atrih, M Foretz, B Viollet, DJ Lamont, DA Cantrell, DG Hardie
Cell Reports 2019
Role of Mitochondria in the Mechanism(s) of Action of Metformin
G Vial, D Detaille, B Guigas
Frontiers in Endocrinology 2019
Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study
T Bryrup, CW Thomsen, T Kern, KH Allin, I Brandslund, NR Jørgensen, H Vestergaard, T Hansen, TH Hansen, O Pedersen, T Nielsen
Diabetologia 2019
Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation
D Tomar, F Jaña, Z Dong, WJ Quinn, P Jadiya, SL Breves, CC Daw, S Srikantan, S Shanmughapriya, N Nemani, E Carvalho, A Tripathi, AM Worth, X Zhang, R Razmpour, A Seelam, S Rhode, AV Mehta, M Murray, D Slade, SH Ramirez, P Mishra, GS Gerhard, J Caplan, L Norton, K Sharma, S Rajan, D Balciunas, DS Wijesinghe, RS Ahima, JA Baur, M Madesh
Cell Reports 2019
Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine
A Brandt, A Hernández-Arriaga, R Kehm, V Sánchez, CJ Jin, A Nier, A Baumann, A Camarinha-Silva, I Bergheim
Scientific Reports 2019
β-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells
CL Crocker, BL Baumgarner, ST Kinsey
Journal of Muscle Research and Cell Motility 2019
Editorial: Metformin: Beyond Diabetes
F Bost, G Rena, B Viollet
Frontiers in Endocrinology 2019
Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial
JM Kristensen, C Lillelund, R Kjøbsted, JB Birk, NR Andersen, L Nybo, K Mellberg, A Balendran, EA Richter, JF Wojtaszewski
Physiological Reports 2019
Similarities and Distinctions in the Effects of Metformin and Carbon Monoxide in Immunometabolism
Jeongmin Park, Yeonsoo Joe, Stefan W Ryter, Young-Joon Surh, Hun Taeg Chung
Molecules and Cells 2019
Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells
M Shum, VP Houde, V Bellemare, RJ Moreira, K Bellmann, P St-Pierre, B Viollet, M Foretz, A Marette
The Journal of biological chemistry 2019
CaMKK2 Signaling in Metabolism and Skeletal Disease: a New Axis with Therapeutic Potential
JN Williams, U Sankar
Current Osteoporosis Reports 2019
The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?
D Vara-Ciruelos, FM Russell, DG Hardie
Open Biology 2019
From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research
RM Khan, ZJ Chua, JC Tan, Y Yang, Z Liao, Y Zhao
MED LITH 2019
Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice
S Kurstjens, H Bouras, C Overmars-Bos, M Kebieche, RJ Bindels, JG Hoenderop, JH de Baaij
Scientific Reports 2019
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
Y Wang, H An, T Liu, C Qin, H Sesaki, S Guo, S Radovick, M Hussain, A Maheshwari, FE Wondisford, B ORourke, L He
Cell Reports 2019
Hepatic exposure of metformin in patients with non‐alcoholic fatty liver disease
EI Sundelin, LC Gormsen, S Heebøll, MH Vendelbo, S Jakobsen, OL Munk, S Feddersen, K Brøsen, SJ HamiltonDutoit, SB Pedersen, H Grønbæk, N Jessen
British Journal of Clinical Pharmacology 2019
Metformin as Anti-Aging Therapy: Is It for Everyone?
AA Soukas, H Hao, L Wu
Trends in endocrinology and metabolism: TEM 2019
Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action
HI Kim, JS Lee, BK Kwak, WM Hwang, MJ Kim, YB Kim, SS Chung, KS Park
Diabetes & Metabolism Journal 2019
Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems
Tavakol, Ashrafizadeh, Deng, Azarian, Abdoli, Motavaf, Poormoghadam, Khanbabaei, Afshar, Mandegary, Pardakhty, Yap, Mohammadinejad, Kumar
Biomolecules 2019
Does Metformin Assist New Anti-Diabetic Drugs to Succeed?
H Kastuyama, H Yanai
Journal of clinical medicine research 2019
Energy Metabolism Couples Hepatocyte Integrin-linked Kinase to Liver Glucoregulation and the Postabsorptive Response of Mice in an Age-dependent Manner
E Trefts, CC Hughey, L Lantier, DS Lark, KL Boyd, A Pozzi, R Zent, DH Wasserman
American journal of physiology. Endocrinology and metabolism 2019
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
T Zhou, T Zhao, F Ma, Y Zhang, J Jiang, Y Ruan, Q Yan, G Wang, J Ren, X Guan, J Guo, Y Zhao, J Ye, L Hu, J Chen, X Shen
Acta Pharmacologica Sinica 2019
Isotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cells
ME Albertolle, SM Glass, E Trefts, FP Guengerich
The Journal of biological chemistry 2019
Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport
O Horakova, P Kroupova, K Bardova, J Buresova, P Janovska, J Kopecky, M Rossmeisl
Scientific Reports 2019
Metformin and Breast Cancer: Molecular Targets
J Faria, G Negalha, A Azevedo, F Martel
Journal of Mammary Gland Biology and Neoplasia 2019

The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances


P Saraei, I Asadi, MA Kakar, N Moradi-Kor
Cancer management and research 2019
Metformin poisoning treated with high dose insulin dextrose therapy: a case series
T Young, J Cevallos, J Napier, J Martin-Lazaro
Acta medica Lituanica 2019
AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells
J Trillo-Tinoco, RA Sierra, E Mohamed, Y Cao, Á de Mingo-Pulido, DL Gilvary, CM Anadon, TL Costich, S Wei, ER Flores, B Ruffell, JR Conejo-Garcia, PC Rodriguez
Cancer research 2019
Metformin Alters Locomotor and Cognitive Function and Brain Metabolism in Normoglycemic Mice
W Li, K Chaudhari, R Shetty, A Winters, X Gao, Z Hu, WP Ge, N Sumien, M Forster, R Liu, SH Yang
Aging and disease 2019
Metformin prevents the pathological browning of subcutaneous white adipose tissue
C Auger, CM Knuth, A Abdullahi, O Samadi, A Parousis, MG Jeschke
Molecular Metabolism 2019
AMPK Activation Promotes Tight Junction Assembly in Intestinal Epithelial Caco-2 Cells
S Olivier, J Leclerc, A Grenier, M Foretz, J Tamburini, B Viollet
International journal of molecular sciences 2019
Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level
Y Tanaka, A Konishi, H Obinata, M Tsuneoka
Scientific Reports 2019
AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR
C Collodet, M Foretz, M Deak, L Bultot, S Metairon, B Viollet, G Lefebvre, F Raymond, A Parisi, G Civiletto, P Gut, P Descombes, K Sakamoto
The FASEB Journal 2019
AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
D Kazyken, B Magnuson, C Bodur, HA Acosta-Jaquez, D Zhang, X Tong, TM Barnes, GK Steinl, NE Patterson, CH Altheim, N Sharma, K Inoki, GD Cartee, D Bridges, L Yin, SM Riddle, DC Fingar
Science signaling 2019
Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
BD Stein, D Calzolari, K Hellberg, YS Hu, L He, CM Hung, EQ Toyama, DS Ross, BF Lillemeier, LC Cantley, JR Yates, RJ Shaw
Cell Reports 2019
The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose-response of randomized clinical trials.
Rahmani J, Manzari N, Thompson J, Gudi SK, Chhabra M, Naik G, Mousavi SM, Varkaneh HK, Clark C, Zhang Y
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2019
AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development
N Boudaba, A Marion, C Huet, R Pierre, B Viollet, M Foretz
EBioMedicine 2018
Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity
Z Polianskyte-Prause, TA Tolvanen, S Lindfors, V Dumont, M Van, H Wang, SN Dash, M Berg, JB Naams, LC Hautala, H Nisen, T Mirtti, PH Groop, K Wähälä, J Tienari, S Lehtonen
The FASEB Journal 2018
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models
RM Esquejo, CT Salatto, J Delmore, B Albuquerque, A Reyes, Y Shi, R Moccia, E Cokorinos, M Peloquin, M Monetti, J Barricklow, E Bollinger, BK Smith, EA Day, C Nguyen, KF Geoghegan, JM Kreeger, A Opsahl, J Ward, AS Kalgutkar, D Tess, L Butler, N Shirai, TF Osborne, GR Steinberg, MJ Birnbaum, KO Cameron, RA Miller
EBioMedicine 2018
Reduced Skeletal Muscle Phosphocreatine Concentration in Type 2 Diabetic Patients: A Quantitative Image-Based Phosphorus-31 MR Spectroscopy Study
EM Ripley, GD Clarke, V Hamidi, RA Martinez, FD Settles, C Solis, S Deng, M Abdul-Ghani, D Tripathy, RA DeFronzo
American journal of physiology. Endocrinology and metabolism 2018
The beta secretase BACE1 regulates the expression of insulin receptor in the liver
PJ Meakin, A Mezzapesa, E Benabou, ME Haas, B Bonardo, M Grino, JM Brunel, C Desbois-Mouthon, SB Biddinger, R Govers, ML Ashford, F Peiretti
Nature Communications 2018
Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment
S Sormendi, B Wielockx
Frontiers in immunology 2018
Meta- and cross-species analyses of insulin resistance based on gene expression datasets in human white adipose tissues
J Jung, GW Kim, W Lee, C Mok, SH Chung, W Jang
Scientific Reports 2018
The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function
XM Caravia, V Fanjul, E Oliver, D Roiz-Valle, A Morán-Álvarez, G Desdín-Micó, M Mittelbrunn, R Cabo, JA Vega, F Rodríguez, A Fueyo, M Gómez, M Lobo-González, H Bueno, G Velasco, JM Freije, V Andrés, B Ibáñez, AP Ugalde, C López-Otín, C Lo
PLoS Biology 2018
Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding
L Zhu, J Shi, TN Luu, JC Neuman, E Trefts, S Yu, BT Palmisano, DH Wasserman, MR Linton, JM Stafford
Molecular Metabolism 2018
Metformin selectively targets redox control of complex I energy transduction
AR Cameron, L Logie, K Patel, S Erhardt, S Bacon, P Middleton, J Harthill, C Forteath, JT Coats, C Kerr, H Curry, D Stewart, K Sakamoto, P Repiščák, MJ Paterson, I Hassinen, G McDougall, G Rena
Redox Biology 2018
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
J Fang, J Yang, X Wu, G Zhang, T Li, X Wang, H Zhang, C Wang, GH Liu, L Wang
Aging Cell 2018
Metformin, an Anti-diabetic Drug to Target Leukemia
G Biondani, JF Peyron
Frontiers in Endocrinology 2018
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
RW Hunter, CC Hughey, L Lantier, EI Sundelin, M Peggie, E Zeqiraj, F Sicheri, N Jessen, DH Wasserman, K Sakamoto
Nature Medicine 2018
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
AK Madiraju, Y Qiu, RJ Perry, Y Rahimi, XM Zhang, D Zhang, JP Camporez, GW Cline, GM Butrico, BE Kemp, G Casals, GR Steinberg, DF Vatner, KF Petersen, GI Shulman
Nature Medicine 2018
Metformin as an Anticancer Agent
A Vancura, P Bu, M Bhagwat, J Zeng, I Vancurova
Trends in Pharmacological Sciences 2018
Metformin from mother to unborn child – Are there unwarranted effects?
L Nguyen, SY Chan, AK Teo
EBioMedicine 2018
Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal
JK Brynildsen, BG Lee, IJ Perron, S Jin, SF Kim, JA Blendy
Proceedings of the National Academy of Sciences 2018
The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease
SS Zarghani, S Abbaszadeh, M Alizadeh, M Rameshrad, A Garjani, H Soraya
Advanced pharmaceutical bulletin 2018
Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes
DM Rotroff, SW Yee, K Zhou, SW Marvel, HS Shah, JR Jack, TM Havener, MM Hedderson, M Kubo, MA Herman, H Gao, JC Mychaleckyi, HL McLeod, A Doria, KM Giacomini, ER Pearson, MJ Wagner, JB Buse, AA Motsinger-Reif
Diabetes 2018
The NOAEL Metformin Dose Is Ineffective against Metabolic Disruption Induced by Chronic Cadmium Exposure in Wistar Rats
V Sarmiento-Ortega, E Brambila, J Flores-Hernández, A Díaz, U Peña-Rosas, D Moroni-González, V Aburto-Luna, S Treviño
Toxics 2018
Association of Metformin Treatment with Reduced Severity of Diabetic Retinopathy in Type 2 Diabetic Patients
Y Li, C Ryu, M Munie, S Noorulla, S Rana, P Edwards, H Gao, X Qiao
Journal of Diabetes Research 2018
Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment
M Li, X Li, H Zhang, Y Lu
Frontiers in physiology 2018
Pleiotropic Effects of Metformin on Cancer
HJ Schulten
International journal of molecular sciences 2018
Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway
X Han, B Wang, Y Sun, J Huang, X Wang, W Ma, Y Zhu, R Xu, H Jin, N Liu
Frontiers in pharmacology 2018
Bidirectional regulation of adenosine 5′-monophosphate-activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration: XIAO et al
Y Xiao, M Xu, M Alimujiang, Y Bao, L Wei, J Yin
Journal of Cellular Biochemistry 2018
Mapping of biguanide transporters in human fat cells and their impact on lipolysis
P Arner, A Kulyté, K Batchelor, J Laurencikiene, J Livingston, M Rydén
Diabetes, obesity & metabolism 2018
Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)
L Logie, Z Lees, JW Allwood, G McDougall, C Beall, G Rena
Diabetes, obesity & metabolism 2018
Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes: A systematic review
EP Mato, M Guewo-Fokeng, MF Essop, PM Owira
Medicine 2018
Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes mellitus: a systematic review protocol
EP Mato, M Guewo-Fokeng, MF Essop, PM Owira
Systematic Reviews 2018
Metformin-Induced Mitochondrial Complex I Inhibition: Facts, Uncertainties, and Consequences
E Fontaine
Frontiers in Endocrinology 2018
Metformin in Reproductive Biology
M Faure, MJ Bertoldo, R Khoueiry, A Bongrani, F Brion, C Giulivi, J Dupont, P Froment
Frontiers in Endocrinology 2018
Keeping the home fires burning: AMP-activated protein kinase
DG Hardie
Journal of The Royal Society Interface 2018
Metformin Affects Heme Function as a Possible Mechanism of Action
X Li, X Wang, MP Snyder
G3: Genes|Genomes|Genetics 2018
Calcium Signaling in Liver Injury and Regeneration
N Oliva-Vilarnau, S Hankeova, SU Vorrink, S Mkrtchian, ER Andersson, VM Lauschke
Frontiers in Medicine 2018
Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells
V Chukkapalli, LI Gordon, P Venugopal, JA Borgia, R Karmali
Oncotarget 2018
Adiposity Results in Metabolic and Inflammation Differences in Premenopausal and Postmenopausal Women Consistent with the Difference in Breast Cancer Risk
H Zhao, J Wang, D Fang, O Lee, RT Chatterton, V Stearns, SA Khan, SE Bulun
Hormones and Cancer 2018
Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential
MN Wein, M Foretz, DE Fisher, RJ Xavier, HM Kronenberg
Trends in endocrinology and metabolism: TEM 2018
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
JN Justice, L Ferrucci, AB Newman, VR Aroda, JL Bahnson, J Divers, MA Espeland, S Marcovina, MN Pollak, SB Kritchevsky, N Barzilai, GA Kuchel
GeroScience 2018
Antidiabetic drugs influence molecular mechanisms in prostate cancer
A Pircher, M Zieher, A Eigentler, R Pichler, G Schäfer, J Fritz, M Puhr, E Steiner, W Horninger, H Klocker, I Heidegger
Cancer biology & therapy 2018
Metformin Treatment Inhibits Motility and Invasion of Glioblastoma Cancer Cells
MA Hassan, I Fakhoury, ZE Masri, N Ghazale, R Dennaoui, OE Atat, A Kanaan, M El-Sibai
Analytical cellular pathology (Amsterdam) 2018
Genotypic and Phenotypic Factors Influencing Drug Response in Mexican Patients With Type 2 Diabetes Mellitus
HE Sanchez-Ibarra, LM Reyes-Cortes, XL Jiang, CM Luna-Aguirre, D Aguirre-Trevino, IA Morales-Alvarado, RB Leon-Cachon, F Lavalle-Gonzalez, F Morcos, HA Barrera-Saldaña
Frontiers in pharmacology 2018
AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation
M Saxena, SA Balaji, N Deshpande, S Ranganathan, DM Pillai, SK Hindupur, A Rangarajan
Journal of cell science 2018
Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1
A Li, Q Liu, Q Li, B Liu, Y Yang, N Zhang
EBioMedicine 2018
Pharmaceutical Impact of Houttuynia Cordata and Metformin Combination on High-Fat-Diet-Induced Metabolic Disorders: Link to Intestinal Microbiota and Metabolic Endotoxemia
JH Wang, S Bose, NR Shin, YW Chin, YH Choi, H Kim
Frontiers in Endocrinology 2018
Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes
LR Sedgeman, C Beysen, RM Allen, MA Solano, SM Turner, KC Vickers
AJP Gastrointestinal and Liver Physiology 2018
Does the antidiabetic drug metformin affect embryo development and the health of brown trout (Salmo trutta f. fario)?
S Jacob, A Dötsch, S Knoll, HR Köhler, E Rogall, D Stoll, S Tisler, C Huhn, T Schwartz, C Zwiener, R Triebskorn
Environmental Sciences Europe 2018
Metformin: A Candidate Drug for Renal Diseases
R Corremans, BA Vervaet, PC DHaese, E Neven, A Verhulst
International journal of molecular sciences 2018
CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis
L Penfold, A Woods, P Muckett, AY Nikitin, TR Kent, S Zhang, R Graham, A Pollard, D Carling
Cancer research 2018
Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism
A Alshawi, L Agius
The Journal of biological chemistry 2018
PHARMACOGENETICS OF ANTI-DIABETIC DRUGS
Srinivasan S, Yee SW, Giacomini KM
Advances in pharmacology (San Diego, Calif.) 2018
Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation
WL Hou, J Yin, M Alimujiang, XY Yu, LG Ai, Y Bao, F Liu, WP Jia
Journal of Cellular and Molecular Medicine 2017
Metformin causes a futile intestinal–hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state
P Schommers, A Thurau, I Bultmann-Mellin, M Guschlbauer, AR Klatt, J Rozman, M Klingenspor, MH de Angelis, J Alber, D Gründemann, A Sterner-Kock, RJ Wiesner
Molecular Metabolism 2017
Lorcaserin improves glycemic control via a melanocortin neurocircuit
LK Burke, E Ogunnowo-Bada, T Georgescu, C Cristiano, PB de Morentin, LV Torres, G D'Agostino, C Riches, N Heeley, Y Ruan, M Rubinstein, MJ Low, MG Myers, JJ Rochford, ML Evans, LK Heisler
Molecular Metabolism 2017
Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation
CM Hasenour, DE Ridley, FD James, CC Hughey, EP Donahue, B Viollet, M Foretz, JD Young, DH Wasserman, L Bertrand
PloS one 2017
Catabolic and anabolic faces of insulin resistance and their disorders: a new insight into circadian control of metabolic disorders leading to diabetes
PM Schwartsburd
Future Science OA 2017
Regulation of hepatic glucose metabolism in health and disease
MC Petersen, DF Vatner, GI Shulman
Nature Reviews Endocrinology 2017
Pharmacogenetics in type 2 diabetes: precision medicine or discovery tool?
JC Florez
Diabetologia 2017
Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet
A Woods, JR Williams, PJ Muckett, FV Mayer, M Liljevald, M Bohlooly-Y, D Carling
Cell Reports 2017
Metformin to Augment Strength Training Effective Response in Seniors (MASTERS): study protocol for a randomized controlled trial
DE Long, BD Peck, JL Martz, SC Tuggle, HM Bush, G McGwin, PA Kern, MM Bamman, CA Peterson
Trials 2017
To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents
I Arbeláez-Quintero, M Palacios
Stroke Research and Treatment 2017
AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis
Y Wang, L Jia, Z Hu, ML Entman, WE Mitch, Y Wang
Kidney International 2017
The mechanisms of action of metformin
G Rena, DG Hardie, ER Pearson
Diabetologia 2017
Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes
AY Dawed, A Ali, K Zhou, ER Pearson, PW Franks
Diabetologia 2017
AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes
JC Deschemin, M Foretz, B Viollet, S Vaulont
Scientific Reports 2017
Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems
SS Udhane, B Legeza, N Marti, D Hertig, G Diserens, JM Nuoffer, P Vermathen, CE Flück
Scientific Reports 2017
AMPK: guardian of metabolism and mitochondrial homeostasis
S Herzig, RJ Shaw
Nature Reviews Molecular Cell Biology 2017
Metformin and berberine, two versatile drugs in treatment of common metabolic diseases
H Wang, C Zhu, Y Ying, L Luo, D Huang, Z Luo
Oncotarget 2017
Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice
JL Xu, LY Li, YQ Wang, YQ Li, M Shan, SZ Sun, Y Yu, B Wang
Journal of lipid research 2017
Dissecting the role of AMP-activated protein kinase in human diseases
J Li, L Zhong, F Wang, H Zhu
Acta Pharmaceutica Sinica B 2017
Fibroblast growth factor 21 and its novel association with oxidative stress
MÁ Gómez-Sámano, M Grajales-Gómez, JM Zuarth-Vázquez, MF Navarro-Flores, M Martínez-Saavedra, ÓA Juárez-León, MG Morales-García, VM Enríquez-Estrada, FJ Gómez-Pérez, D Cuevas-Ramos
Redox Biology 2017
Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation
SJ Mancini, AD White, S Bijland, C Rutherford, D Graham, EA Richter, B Viollet, RM Touyz, TM Palmer, IP Salt
Molecular and Cellular Endocrinology 2017
Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis
JA Loos, VA Dávila, CR Rodrígues, R Petrigh, JA Zoppi, FA Crocenzi, AC Cumino, A Casulli
PLoS neglected tropical diseases 2017
The Liver Circadian Clock Modulates Biochemical and Physiological Responses to Metformin
E Henriksson, AL Huber, EK Soto, A Kriebs, ME Vaughan, D Duglan, AB Chan, SJ Papp, M Nguyen, ME Afetian, KA Lamia
Journal of Biological Rhythms 2017
Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice
CC Hughey, FD James, DP Bracy, EP Donahue, JD Young, B Viollet, M Foretz, DH Wasserman
The Journal of biological chemistry 2017
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
B Bilanges, S Alliouachene, W Pearce, D Morelli, G Szabadkai, YL Chung, G Chicanne, C Valet, JM Hill, PJ Voshol, L Collinson, C Peddie, K Ali, E Ghazaly, V Rajeeve, G Trichas, S Srinivas, C Chaussade, RS Salamon, JM Backer, CL Scudamore, MA Whitehead, EP Keaney, LO Murphy, RK Semple, B Payrastre, SA Tooze, B Vanhaesebroeck
Nature Communications 2017
Role of AMPD2 in impaired glucose tolerance induced by high fructose diet
AW Hudoyo, T Hirase, A Tandelillin, M Honda, M Shirai, J Cheng, H Morisaki, T Morisaki
Molecular Genetics and Metabolism Reports 2017
A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer
AS Khan, DE Frigo
Nature Reviews Urology 2017
Ginsenoside Rg5 Inhibits Succinate-Associated Lipolysis in Adipose Tissue and Prevents Muscle Insulin Resistance
N Xiao, LL Yang, YL Yang, LW Liu, J Li, B Liu, K Liu, LW Qi, P Li
Frontiers in pharmacology 2017
Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation
S Xu, CX Liu, W Xu, L Huang, JY Zhao, SM Zhao
Signal Transduction and Targeted Therapy 2017
Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration
D Athanasiou, M Aguila, CA Opefi, K South, J Bellingham, D Bevilacqua, PM Munro, N Kanuga, FE Mackenzie, AM Dubis, A Georgiadis, AB Graca, RA Pearson, RR Ali, S Sakami, K Palczewski, MY Sherman, PJ Reeves, ME Cheetham
Human Molecular Genetics 2017
The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis
A Qiao, X Jin, J Pang, D Moskophidis, NF Mivechi
The Journal of Cell Biology 2017
Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice
AJ Albaghdadi, MA Hewitt, SM Putos, M Wells, TR Ozolinš, FW Kan
Journal of Translational Medicine 2017
Meta-analysis of studies using metformin as a reducer for liver cancer risk in diabetic patients:
S Ma, Y Zheng, Y Xiao, P Zhou, H Tan
Medicine 2017
Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice
S Shiba, K Ikeda, K Horie-Inoue, A Nakayama, T Tanaka, S Inoue
Scientific Reports 2017
New Evidence for the Mechanism of Action of a Type-2 Diabetes Drug Using a Magnetic Bead-Based Automated Biosensing Platform
R Uddin, Nur-E-Habiba, G Rena, ET Hwu, A Boisen
ACS Sensors 2017
Nanoformulation of Leonotis leonurus to improve its bioavailability as a potential antidiabetic drug
F Odei-Addo, R Shegokar, RH Müller, RA Levendal, C Frost
3 Biotech 2017
Metformin: new insights into an archetypal cardiometabolic drug
AJ Krentz
Cardiovascular Endocrinology 2017
The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation
Y Huang, CA Smith, G Chen, B Sharma, AS Miner, RW Barbee, PH Ratz
Frontiers in pharmacology 2017
Exercise training and metformin, but not exercise training alone, decreases insulin production and increases insulin clearance in adults with prediabetes
R Viskochil, SK Malin, JM Blankenship, B Braun
Journal of applied physiology 2017
Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
SC Chen, R Brooks, J Houskeeper, SK Bremner, J Dunlop, B Viollet, PJ Logan, IP Salt, SF Ahmed, SJ Yarwood
Molecular and Cellular Endocrinology 2017
Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase
J Huang, Y Zhou, B Wan, Q Wang, X Wan, H Wang
PloS one 2017
Health benefits of late-onset metformin treatment every other week in mice
I Alfaras, SJ Mitchell, H Mora, DR Lugo, A Warren, I Navas-Enamorado, V Hoffmann, C Hine, JR Mitchell, DG le Couteur, VC Cogger, M Bernier, R Cabo
npj Aging and Mechanisms of Disease 2017
Towards natural mimetics of metformin and rapamycin
A Aliper, L Jellen, F Cortese, A Artemov, D Karpinsky-Semper, A Moskalev, AG Swick, A Zhavoronkov
Aging 2017
Expression profile analysis of long non-coding RNAs involved in the metformin-inhibited gluconeogenesis of primary mouse hepatocytes
Y Wang, H Tang, X Ji, Y Zhang, W Xu, X Yang, R Deng, Y Liu, F Li, X Wang, L Zhou
International journal of molecular medicine 2017
Metformin in combination with cisplatin inhibits cell viability and induces apoptosis of human ovarian cancer cells by inactivating ERK 1/2
JH Dang, ZJ Jin, XJ Liu, D Hu, J Wang, Y Luo, LL Li
Oncology Letters 2017
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.
Wu H, Esteve E, Tremaroli V, Khan MT, Caesar R, Mannerås-Holm L, Ståhlman M, Olsson LM, Serino M, Planas-Fèlix M, Xifra G, Mercader JM, Torrents D, Burcelin R, Ricart W, Perkins R, Fernàndez-Real JM, Bäckhed F
Nature Medicine 2017
p53 coordinates decidual Sestrin2-AMPK-mTORC1 signaling to govern parturition timing
Wenbo Deng, Jeeyeon Cha, Jia Yuan, Hirofumi Haraguchi, Amanda Bartos, Emma Leishman, Benoit Viollet, Heather Bradshaw, Yasushi Hirota, Sudhansu Dey
Journal of Clinical Investigation 2016
Genomic Characterization of Metformin Hepatic Response
MR Luizon, WL Eckalbar, Y Wang, SL Jones, RP Smith, M Laurance, L Lin, PJ Gallins, AS Etheridge, F Wright, Y Zhou, C Molony, F Innocenti, SW Yee, KM Giacomini, N Ahituv, EM Mendenhall
PLoS genetics 2016
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
AK Rines, K Sharabi, CD Tavares, P Puigserver
Nature Reviews Drug Discovery 2016
Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug
AR Cameron, L Logie, K Patel, S Bacon, C Forteath, J Harthill, A Roberts, C Sutherland, D Stewart, B Viollet, K Sakamoto, G McDougall, M Foretz, G Rena
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016
The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development
J Gong, G Kelekar, J Shen, J Shen, S Kaur, M Mita
Targeted Oncology 2016
Diabetes mellitus and metformin in hepatocellular carcinoma
K Fujita, H Iwama, H Miyoshi, J Tani, K Oura, T Tadokoro, T Sakamoto, T Nomura, A Morishita, H Yoneyama, T Masaki
World journal of gastroenterology : WJG 2016
Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY: results from two randomised trials
RA DeFronzo, JB Buse, T Kim, C Burns, S Skare, A Baron, M Fineman
Diabetologia 2016
Nuclear receptors and AMPK: can exercise mimetics cure diabetes?
CE Wall, RT Yu, AR Atkins, M Downes, RM Evans
Journal of Molecular Endocrinology 2016
Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules
S Kumar, DB Lombard
F1000Research 2016
AMPK activators: mechanisms of action and physiological activities
J Kim, G Yang, Y Kim, J Kim, J Ha
Experimental & molecular medicine 2016
Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy
AD McCarthy, AM Cortizo, C Sedlinsky
World journal of diabetes 2016
AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
M Johanns, YC Lai, MF Hsu, R Jacobs, D Vertommen, JV Sande, JE Dumont, A Woods, D Carling, L Hue, B Viollet, M Foretz, MH Rider
Nature Communications 2016
Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase
Q Guo, Z Liu, L Jiang, M Liu, J Ma, C Yang, L Han, K Nan, X Liang
Molecular medicine reports 2016
Energy disruptors: rising stars in anticancer therapy?
F Bost, AG Decoux-Poullot, JF Tanti, S Clavel
Oncogenesis 2016
The Na + /Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
SA Hawley, RJ Ford, BK Smith, GJ Gowans, SJ Mancini, RD Pitt, EA Day, IP Salt, GR Steinberg, DG Hardie
Diabetes 2016
Current understanding of metformin effect on the control of hyperglycemia in diabetes
H An, L He
Journal of Endocrinology 2016
Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy
A Hasanvand, H Amini-khoei, MR Hadian, A Abdollahi, SM Tavangar, AR Dehpour, E Semiei, SE Mehr
Inflammopharmacology 2016
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance
AR Cameron, VL Morrison, D Levin, M Mohan, C Forteath, C Beall, AD McNeilly, DJ Balfour, T Savinko, AK Wong, B Viollet, K Sakamoto, SC Fagerholm, M Foretz, CC Lang, G Rena
Circulation research 2016
Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling
T Yuasa, K Amo-Shiinoki, S Ishikura, M Takahara, T Matsuoka, H Kaneto, A Kuroda, M Matsuhisa, S Hashida
Diabetologia 2016
lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1
X Liu, B Gan
Cell cycle (Georgetown, Tex.) 2016
Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney
M Christensen, JB Jensen, S Jakobsen, N Jessen, J Frøkiær, BE Kemp, AL Marciszyn, H Li, NM Pastor-Soler, KR Hallows, R Nørregaard
Scientific Reports 2016
An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer
L Wu, B Zhou, N Oshiro-Rapley, M Li, JA Paulo, CM Webster, F Mou, MC Kacergis, ME Talkowski, CE Carr, SP Gygi, B Zheng, AA Soukas
Cell 2016
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer
B Dasgupta, RR Chhipa
Trends in Pharmacological Sciences 2016
Hypothalamic AMPK: a canonical regulator of whole-body energy balance
M López, R Nogueiras, M Tena-Sempere, C Diéguez
Nature Reviews Endocrinology 2016
Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD
DS Sonnet, MN OLeary, MA Gutierrez, SM Nguyen, S Mateen, Y Hsu, KP Mitchell, AJ Lopez, J Vockley, BK Kennedy, A Ramanathan
Scientific Reports 2016
AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2
S Fogarty, FA Ross, DV Ciruelos, A Gray, GJ Gowans, DG Hardie
Molecular cancer research : MCR 2016
Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet
SL Slocum, JJ Skoko, N Wakabayashi, S Aja, M Yamamoto, TW Kensler, DV Chartoumpekis
Archives of Biochemistry and Biophysics 2016
Targeting Select Cellular Stress Pathways to Prevent Hyperglycemia-Related Complications: Shifting the Paradigm
AD Mooradian
Drugs 2016
Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents
E Pearson, A Dawed, K Zhou
Pharmacogenomics and Personalized Medicine 2016
Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport
J Velez, R Pan, JT Lee, L Enciso, M Suarez, JE Duque, D Jaramillo, C Lopez, L Morales, W Bornmann, M Konopleva, G Krystal, M Andreeff, I Samudio
Oncotarget 2016
Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes
AR Konopka, RR Esponda, MM Robinson, ML Johnson, RE Carter, M Schiavon, C Cobelli, FE Wondisford, IR Lanza, KS Nair
Cell Reports 2016
Changes in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selection
AI Vatsiou, E Bazin, OE Gaggiotti
BMC Genomics 2016
Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt
C Marini, S Ravera, A Buschiazzo, G Bianchi, AM Orengo, S Bruno, G Bottoni, L Emionite, F Pastorino, E Monteverde, L Garaboldi, R Martella, B Salani, D Maggi, M Ponzoni, F Fais, L Raffaghello, G Sambuceti
Scientific Reports 2016
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling
Z Zhou, L Ren, P Zhan, H Yang, D Chai, Z Yu
Acta Pharmacologica Sinica 2016
Effect of Cichorium intybus L. on the expression of hepatic NF-κB and IKKβ and serum TNF-α in STZ− and STZ+ niacinamide-induced diabetes in rats
L Rezagholizadeh, Y Pourfarjam, A Nowrouzi, M Nakhjavani, A Meysamie, N Ziamajidi, PS Nowrouzi
Diabetology & metabolic syndrome 2016
Metformin as a Tool to Target Aging
N Barzilai, JP Crandall, SB Kritchevsky, MA Espeland
Cell Metabolism 2016
Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice
M Shum, K Bellmann, P St-Pierre, A Marette
Diabetologia 2016
Does Metformin Reduce Cancer Risks? Methodologic Considerations
A Golozar, S Liu, JA Lin, K Peairs, HC Yeh
Current Diabetes Reports 2016
Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance
SR Sayers, F Reimann, FM Gribble, H Parker, S Zac-Varghese, SR Bloom, M Foretz, B Viollet, GA Rutter, FC Lynn
PloS one 2016
Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts
MB Lipner, R Marayati, Y Deng, X Wang, L Raftery, BH ONeil, JJ Yeh, MJ Boucher
PloS one 2016
Deletion of Lkb1 in adult mice results in body weight reduction and lethality
T Shan, Y Xiong, S Kuang
Scientific Reports 2016
Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks
V Mallikarjun, J Swift
EBioMedicine 2016
Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells
L Galdieri, H Gatla, I Vancurova, A Vancura
The Journal of biological chemistry 2016
Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription
A Diman, J Boros, F Poulain, J Rodriguez, M Purnelle, H Episkopou, L Bertrand, M Francaux, L Deldicque, A Decottignies
Science Advances 2016
Metformin enhances the radiosensitivity of human liver cancer cells to γ–rays and carbon ion beams
EH Kim, MS Kim, Y Furusawa, A Uzawa, S Han, WG Jung, S Sai
Oncotarget 2016
Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle
L Bultot, TE Jensen, YC Lai, AL Madsen, C Collodet, S Kviklyte, M Deak, A Yavari, M Foretz, S Ghaffari, M Bellahcene, H Ashrafian, MH Rider, EA Richter, K Sakamoto
American journal of physiology. Endocrinology and metabolism 2016
Metformin: A Hopeful Promise in Aging Research
MG Novelle, A Ali, C Diéguez, M Bernier, R de Cabo
Cold Spring Harbor Perspectives in Medicine 2016
AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?
Moreira D, Silvestre R, Cordeiro-da-Silva A, Estaquier J, Foretz M, Viollet B
Current drug targets 2016
Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling
Hung CH, Chan SH, Chu PM, Lin HC, Tsai KL
Oncotarget 2016
Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity
M Nixon, R Stewart-Fitzgibbon, J Fu, D Akhmedov, K Rajendran, MG Mendoza-Rodriguez, YA Rivera-Molina, M Gibson, ED Berglund, NJ Justice, R Berdeaux
Molecular Metabolism 2015
Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2)
A Madsen, O Bozickovic, JI Bjune, G Mellgren, JV Sagen
Scientific Reports 2015
New mechanisms of metformin action: Focusing on mitochondria and the gut
KY Hur, MS Lee
Journal of Diabetes Investigation 2015
Metformin and metabolic diseases: a focus on hepatic aspects
J Zheng, SL Woo, X Hu, R Botchlett, L Chen, Y Huo, C Wu
Frontiers of Medicine 2015
Metformin, an Old Drug, Brings a New Era to Cancer Therapy:
H He, R Ke, H Lin, Y Ying, D Liu, Z Luo
The Cancer Journal 2015
Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats
FA Duca, CD Côté, BA Rasmussen, M Zadeh-Tahmasebi, GA Rutter, BM Filippi, TK Lam
Nature Medicine 2015
Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus
S Tangvarasittichai
World journal of diabetes 2015
Genetics of Drug Response in Type 2 Diabetes
I Tkáč
Current Diabetes Reports 2015
In Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosus
JA Loos, AC Cumino, DW Chan
PloS one 2015
Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes
Y Itoh, M Sanosaka, H Fuchino, Y Yahara, A Kumagai, D Takemoto, M Kagawa, J Doi, M Ohta, N Tsumaki, N Kawahara, H Takemori
The Journal of biological chemistry 2015
Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality
EJ Gallagher, D LeRoith
Physiological reviews 2015
Expanding the therapeutic spectrum of metformin: from diabetes to cancer
F Coperchini, P Leporati, M Rotondi, L Chiovato
Journal of Endocrinological Investigation 2015
Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages
B Kelly, GM Tannahill, MP Murphy, LA O'Neill
The Journal of biological chemistry 2015
Why does obesity promote cancer? Epidemiology, biology, and open questions
L Mazzarella
ecancermedicalscience 2015
Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats
MA Linden, KT Lopez, JA Fletcher, EM Morris, GM Meers, S Siddique, MH Laughlin, JR Sowers, JP Thyfault, JA Ibdah, RS Rector
Applied Physiology, Nutrition, and Metabolism 2015
Molecular pathophysiology of hepatic glucose production
K Sharabi, CD Tavares, AK Rines, P Puigserver
Molecular Aspects of Medicine 2015
Repurposing metformin: an old drug with new tricks in its binding pockets
R Pryor, F Cabreiro
Biochemical Journal 2015
AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease
RP Vázquez-Manrique, F Farina, K Cambon, MD Sequedo, AJ Parker, JM Millán, A Weiss, N Déglon, C Neri
Human Molecular Genetics 2015
Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats
W Jo, ES Yu, M Chang, HK Park, HJ Choi, JE Ryu, S Jang, HJ Lee, JJ Jang, WC Son
Molecular medicine reports 2015
Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium
M Kinaan, H Ding, CR Triggle
Medical Principles and Practice 2015
Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice
V Calabuig-Navarro, J Yamauchi, S Lee, T Zhang, YZ Liu, K Sadlek, GM Coudriet, JD Piganelli, CL Jiang, R Miller, M Lowe, H Harashima, HH Dong
The Journal of biological chemistry 2015
Regulation of AMP-activated protein kinase by natural and synthetic activators
DG Hardie
Acta Pharmaceutica Sinica B 2015
Recent Advances in the Use of Metformin: Can Treating Diabetes Prevent Breast Cancer?
D Hatoum, EM McGowan
BioMed Research International 2015
In Vitro and In Vivo Effects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose Tissue
A Śmieszek, K Basińska, K Chrząstek, K Marycz
Journal of Diabetes Research 2015
Fishing for Nature’s Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products
N Tabassum, H Tai, DW Jung, DR Williams
Evidence-Based Complementary and Alternative Medicine 2015
Combination Therapy with Oleanolic Acid and Metformin as a Synergistic Treatment for Diabetes
X Wang, Y Chen, D Abdelkader, W Hassan, H Sun, J Liu
Journal of Diabetes Research 2015
Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides
S Matsuzaki, KM Humphries
Biochemistry 2015
Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis
D Moreira, V Rodrigues, M Abengozar, L Rivas, E Rial, M Laforge, X Li, M Foretz, B Viollet, J Estaquier, AC da Silva, R Silvestre, M Olivier
PLoS pathogens 2015
Lack of Effect of Metformin on Mammary Carcinogenesis in Nondiabetic Rat and Mouse Models
MD Thompson, CJ Grubbs, AM Bode, JM Reid, R McGovern, PS Bernard, IJ Stijleman, JE Green, C Bennett, MM Juliana, F Moeinpour, VE Steele, RA Lubet
Cancer prevention research (Philadelphia, Pa.) 2015
Duodenal energy sensing regulates hepatic glucose output
BK Smith, GR Steinberg
Nature Medicine 2015
Effect of Metformin on Viability, Morphology, and Ultrastructure of Mouse Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells and Balb/3T3 Embryonic Fibroblast Cell Line
A Śmieszek, A Czyrek, K Basinska, J Trynda, A Skaradzińska, A Siudzińska, M Marędziak, K Marycz
BioMed Research International 2015
Therapy: Metformin takes a new route to clinical efficacy
M Foretz, B Viollet
Nature Reviews Endocrinology 2015
Biologically active, high levels of interleukin-22 inhibit hepatic gluconeogenesis but do not affect obesity and its metabolic consequences
O Park, SH Ki, M Xu, H Wang, D Feng, J Tam, D Osei-Hyiaman, G Kunos, B Gao
Cell & Bioscience 2015
Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo
X Cai, X Hu, X Tan, W Cheng, Q Wang, X Chen, Y Guan, C Chen, X Jing, W Lin
PloS one 2015
Effects of Metformin, Buformin, and Phenformin on the Post-Initiation Stage of Chemically Induced Mammary Carcinogenesis in the Rat
Z Zhu, W Jiang, MD Thompson, D Echeverria, JN McGinley, HJ Thompson
Cancer prevention research (Philadelphia, Pa.) 2015
Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling
KS McCommis, Z Chen, X Fu, WG McDonald, JR Colca, RF Kletzien, SC Burgess, BN Finck
Cell Metabolism 2015
OCT1 in hepatic steatosis and thiamine disposition
L Chen, SW Yee, KM Giacomini
Cell cycle (Georgetown, Tex.) 2015
Clinical benefits of metformin in gynecologic oncology (Review)
A Imai, S Ichigo, K Matsunami, H Takagi, K Yasuda
Oncology Letters 2015
Obesity, Diabetes and Cancer: A Mechanistic Perspective.
Cifarelli V, Hursting SD
International journal of diabetology & vascular disease research 2015
Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells
Bansal N, Mishra PJ, Stein M, DiPaola RS, Bertino JR
Oncotarget 2015
Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells
Loubière C, Goiran T, Laurent K, Djabari Z, Tanti JF, Bost F
Oncotarget 2015
Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics.
Arkwright RT, Deshmukh R, Adapa N, Stevens R, Zonder E, Zhang Z, Farshi P, Ahmed RS, El-Banna HA, Chan TH, Dou QP
Anti-cancer agents in medicinal chemistry 2015
Metformin Interferes With Bile Acid Homeostasis Through AMPK-FXR Crosstalk
Fleur Lien, Alexandre Berthier, Emmanuel Bouchaert, Céline Gheeraert, Jeremy Alexandre, Geoffrey Porez, Janne Prawitt, Hélène Dehondt, Maheul Ploton, Sophie Colin, Anthony Lucas, Alexandre Patrice, François Pattou, Helene Diemer, Alain VAN DORSSELAER, Christophe Rachez, Jelena Kamilic, Albert K. Groen, Bart Staels, Philippe Lefebvre
Journal of Clinical Investigation 2014
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
K Patel, M Foretz, A Marion, DG Campbell, R Gourlay, N Boudaba, E Tournier, P Titchenell, M Peggie, M Deak, M Wan, KH Kaestner, O Göransson, B Viollet, NS Gray, MJ Birnbaum, C Sutherland, K Sakamoto
Nature Communications 2014
Metformin Ameliorates Hepatic Steatosis and Inflammation without Altering Adipose Phenotype in Diet-Induced Obesity
SL Woo, H Xu, H Li, Y Zhao, X Hu, J Zhao, X Guo, T Guo, R Botchlett, T Qi, Y Pei, J Zheng, Y Xu, X An, L Chen, L Chen, Q Li, X Xiao, Y Huo, C Wu
PloS one 2014
Salicylic acid: old and new implications for the treatment of type 2 diabetes?
G Rena, K Sakamoto
Diabetology International 2014
Hepatic FoxO1 Acetylation Is Involved in Oleanolic Acid-Induced Memory of Glycemic Control: Novel Findings from Study 2
X Zhou, XY Zeng, H Wang, S Li, E Jo, CC Xue, M Tan, JC Molero, JM Ye, Y Zhang
PloS one 2014
Perivascular fat, AMP-activated protein kinase and vascular diseases: Perivascular fat and vascular diseases
TA Almabrouk, MA Ewart, IP Salt, S Kennedy
British Journal of Pharmacology 2014
An update on the pharmacogenomics of metformin: progress, problems and potential
JN Todd, JC Florez
Pharmacogenomics 2014
Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
RW Mackenzie, BT Elliott
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014
Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy
HY Lee, D Wei, MR Loeken
Diabetes/Metabolism Research and Reviews 2014
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
WD Haes, L Frooninckx, RV Assche, A Smolders, G Depuydt, J Billen, BP Braeckman, L Schoofs, L Temmerman
Proceedings of the National Academy of Sciences 2014
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
AK Madiraju, DM Erion, Y Rahimi, XM Zhang, DT Braddock, RA Albright, BJ Prigaro, JL Wood, S Bhanot, MJ MacDonald, MJ Jurczak, JP Camporez, HY Lee, GW Cline, VT Samuel, RG Kibbey, GI Shulman
Nature 2014
Metformin—mode of action and clinical implications for diabetes and cancer
I Pernicova, M Korbonits
Nature Reviews Endocrinology 2014
AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels
DG Hardie
Annual Review of Nutrition 2014
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
L Chen, Y Shu, X Liang, EC Chen, SW Yee, AA Zur, S Li, L Xu, KR Keshari, MJ Lin, HC Chien, Y Zhang, KM Morrissey, J Liu, J Ostrem, NS Younger, J Kurhanewicz, KM Shokat, K Ashrafi, KM Giacomini
Proceedings of the National Academy of Sciences 2014
Control of Gluconeogenesis by Metformin: Does Redox Trump Energy Charge?
JA Baur, MJ Birnbaum
Cell Metabolism 2014
Berberine Promotes Glucose Consumption Independently of AMP-Activated Protein Kinase Activation
M Xu, Y Xiao, J Yin, W Hou, X Yu, L Shen, F Liu, L Wei, W Jia
PloS one 2014
AMPK activation: a therapeutic target for type 2 diabetes?
KA Coughlan, RJ Valentine, NB Ruderman, AK Saha
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014
Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective
AM Gusdon, K Song, S Qu
Oxidative medicine and cellular longevity 2014
Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle
S Rodriguez, JM Ellis, MJ Wolfgang
BMC Biochemistry 2014
Cardiovascular impact of drugs used in the treatment of diabetes
CR Triggle, H Ding
Therapeutic Advances in Chronic Disease 2014
Prenatal Metformin Exposure in a Maternal High Fat Diet Mouse Model Alters the Transcriptome and Modifies the Metabolic Responses of the Offspring
H Salomäki, M Heinäniemi, LH Vähätalo, L Ailanen, K Eerola, ST Ruohonen, U Pesonen, M Koulu, M Claret
PloS one 2014
A pharmacogenetic association between a variation in calpain 10 (CAPN10) gene and the response to metformin treatment in patients with type 2 diabetes
I Tkáč, M Javorský, L Klimčáková, J Židzik, I Gaľa, E Babjaková, Z Schroner, M Štolfová, H Hermanová, V Habalová
European Journal of Clinical Pharmacology 2014
Impact of metformin on reproductive tissues: an overview from gametogenesis to gestation
Michael J Bertoldo, Melanie Faure, Joelle Dupont, Pascal Froment
Annals of translational medicine 2014
5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) Effect on Glucose Production, but Not Energy Metabolism, Is Independent of Hepatic AMPK in Vivo
CM Hasenour, DE Ridley, CC Hughey, FD James, EP Donahue, J Shearer, B Viollet, M Foretz, DH Wasserman
The Journal of biological chemistry 2014
Minireview: Hey U(PS): Metabolic and Proteolytic Homeostasis Linked via AMPK and the Ubiquitin Proteasome System
SM Ronnebaum, C Patterson, JC Schisler
Molecular Endocrinology 2014
Metformin Suppresses Lipopolysaccharide (LPS)-induced Inflammatory Response in Murine Macrophages via Activating Transcription Factor-3 (ATF-3) Induction
J Kim, HJ Kwak, JY Cha, YS Jeong, SD Rhee, KR Kim, HG Cheon
The Journal of biological chemistry 2014
Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)
J Cao, S Meng, E Chang, K Beckwith-Fickas, L Xiong, RN Cole, S Radovick, FE Wondisford, L He
The Journal of biological chemistry 2014
Convergence of IPMK and LKB1-AMPK Signaling Pathways on Metformin Action
S Bang, Y Chen, RS Ahima, SF Kim
Molecular Endocrinology 2014
AMPK at the Nexus of Energetics and Aging
K Burkewitz, Y Zhang, WB Mair
Cell Metabolism 2014
AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease
DG Hardie
Journal of Internal Medicine 2014
Cathepsin S inhibition lowers blood glucose levels in mice
JC Lafarge, M Pini, V Pelloux, G Orasanu, G Hartmann, N Venteclef, T Sulpice, GP Shi, K Clément, M Guerre-Millo
Diabetologia 2014
Something old, something new and something very old: drugs for treating type 2 diabetes: Drugs for treating type 2 diabetes
D Kaiser, E Oetjen
British Journal of Pharmacology 2014
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
VP Houde, MS Ritorto, R Gourlay, J Varghese, P Davies, N Shpiro, K Sakamoto, DR Alessi
Biochemical Journal 2014
Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK
RW Hunter, M Foretz, L Bultot, MD Fullerton, M Deak, FA Ross, SA Hawley, N Shpiro, B Viollet, D Barron, BE Kemp, GR Steinberg, DG Hardie, K Sakamoto
Chemistry & Biology 2014
Metformin Protects Against Systolic Overload-Induced Heart Failure Independent of AMP-Activated Protein Kinase  2
X Xu, Z Lu, J Fassett, P Zhang, X Hu, X Liu, D Kwak, J Li, G Zhu, Y Tao, M Hou, H Wang, H Guo, B Viollet, EO McFalls, RJ Bache, Y Chen
Hypertension 2014
Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action
SD Martin, S Morrison, N Konstantopoulos, SL McGee
Molecular Metabolism 2014
Metformin Pharmacogenomics: Current Status and Future Directions
AC Pawlyk, KM Giacomini, C McKeon, AR Shuldiner, JC Florez
Diabetes 2014
microRNAs and cancer metabolism reprogramming: the paradigm of metformin
Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino
Annals of translational medicine 2014
Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance
PJ Meakin, S Chowdhry, RS Sharma, FB Ashford, SV Walsh, RJ McCrimmon, AT Dinkova-Kostova, JF Dillon, JD Hayes, ML Ashford
Molecular and cellular biology 2014
Cancer biology in diabetes
S Sen, Y He, D Koya, K Kanasaki
Journal of Diabetes Investigation 2014
Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions: Metformin selectively affects PGC-1α functions
SM Aatsinki, M Buler, H Salomäki, M Koulu, P Pavek, J Hakkola
British Journal of Pharmacology 2014
High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice
SE Arnold, I Lucki, BR Brookshire, GC Carlson, CA Browne, H Kazi, S Bang, BR Choi, Y Chen, MF McMullen, SF Kim
Neurobiology of Disease 2014
Increased AMP-activated protein kinase in skeletal muscles of Murphy Roth Large mice and its potential role in altered metabolism
TK Berhanu, J Holley-Cuthrell, NW Roberts, AJ Mull, A Heydemann
Physiological Reports 2014
LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes
L Homolya, D Fu, P Sengupta, M Jarnik, JP Gillet, L Vitale-Cross, JS Gutkind, J Lippincott-Schwartz, IM Arias
PloS one 2014
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662
S Ducommun, RJ Ford, L Bultot, M Deak, L Bertrand, BE Kemp, GR Steinberg, K Sakamoto
American journal of physiology. Endocrinology and metabolism 2014
Diazepam potentiates the antidiabetic, antistress and anxiolytic activities of metformin in type-2 diabetes mellitus with cooccurring stress in experimental animals
D Garabadu, S Krishnamurthy
BioMed Research International 2014
Metformin directly acts on mitochondria to alter cellular bioenergetics
S Andrzejewski, SP Gravel, M Pollak, J St-Pierre
Cancer & Metabolism 2014
Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells
M Zarrouk, DK Finlay, M Foretz, B Viollet, DA Cantrell
PloS one 2014
MARCH2: Comparative Assessment of Therapeutic Effects of Acarbose and Metformin in Newly Diagnosed Type 2 Diabetes Patients
G Wang, J Liu, N Yang, X Gao, H Fan, Y Xu, W Yang
PloS one 2014
Roles and regulation of ketogenesis in cultured astroglia and neurons under hypoxia and hypoglycemia
Shinichi Takahashi, Takuya Iizumi, Kyoko Mashima, Takato Abe, Norihiro Suzuki
2014
Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
YM Song, Y Lee, JW Kim, DS Ham, ES Kang, BS Cha, HC Lee, BW Lee
Autophagy 2014
Evidence of Insulin Resistance in Adult Uncomplicated Malaria: Result of a Two-Year Prospective Study
S Acquah, JN Boampong, BA Jnr, M Eriksson
Malaria Research and Treatment 2014
Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
A Luengo, LB Sullivan, MG Heiden
BMC Biology 2014
Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways
Y Jenkins, TQ Sun, Y Li, V Markovtsov, G Uy, L Gross, DA Goff, SJ Shaw, L Boralsky, R Singh, DG Payan, Y Hitoshi
BMC Research Notes 2014
Effect of Metformin on Metabolic Improvement and Gut Microbiota
H Lee, G Ko
Applied and environmental microbiology 2014
Metformin Improves Glucose Effectiveness, Not Insulin Sensitivity: Predicting Treatment Response in Women With Polycystic Ovary Syndrome in an Open-Label, Interventional Study
CT Pau, C Keefe, J Duran, CK Welt
The Journal of clinical endocrinology and metabolism 2014
Targeting the LKB1 tumor suppressor.
Zhao RX, Xu ZX
Current drug targets 2014
Perinatal outcomes in type 2 diabetes.
Hewapathirana NM, Murphy HR
Current Diabetes Reports 2014
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS
eLife 2014
Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment.
Pollak M
Nature Medicine 2014
Potential applications for biguanides in oncology
Michael Pollak
Journal of Clinical Investigation 2013
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
RA Miller, Q Chu, J Xie, M Foretz, B Viollet, MJ Birnbaum
Nature 2013
Molecular mechanism of action of metformin: old or new insights?
G Rena, ER Pearson, K Sakamoto
Diabetologia 2013
Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors
V Nair, S Pathi, I Jutooru, S Sreevalsan, R Basha, M Abdelrahim, I Samudio, S Safe
Carcinogenesis 2013
Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice
JM Kristensen, S Larsen, JW Helge, F Dela, JF Wojtaszewski
PloS one 2013
Metformin and Thyroid: An Update
T Pappa, M Alevizaki
European Thyroid Journal 2013
Management of pediatric and adolescent type 2 diabetes
MC Samaan
International journal of pediatrics 2013
Risk of Cancer in Diabetes: The Effect of Metformin
M Malek, R Aghili, Z Emami, ME Khamseh
ISRN Endocrinology 2013
Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin
SS Wang, R Hsiao, MM Limpar, S Lomahan, TA Tran, NJ Maloney, N Ikegaki, XX Tang
International journal of molecular medicine 2013
Shizukaol D isolated from Chloranthus japonicas inhibits AMPK-dependent lipid content in hepatic cells by inducing mitochondrial dysfunction
R Hu, H Yan, X Hao, H Liu, J Wu
PloS one 2013
LKB1 and AMPK and the cancer-metabolism link - ten years after
DG Hardie, DR Alessi
BMC Biology 2013
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
MD Fullerton, S Galic, K Marcinko, S Sikkema, T Pulinilkunnil, ZP Chen, HM O'Neill, RJ Ford, R Palanivel, M O'Brien, DG Hardie, SL Macaulay, JD Schertzer, JR Dyck, BJ van Denderen, BE Kemp, GR Steinberg
Nature Medicine 2013
Cardiac metabolism in heart failure: implications beyond ATP production
T Doenst, TD Nguyen, ED Abel
Circulation research 2013
Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling
BJ Quinn, M Dallos, H Kitagawa, AB Kunnumakkara, RM Memmott, MC Hollander, JJ Gills, PA Dennis
Cancer prevention research (Philadelphia, Pa.) 2013
Metformin increases mitochondrial energy formation in L6 muscle cell cultures
VS Vytla, RS Ochs
The Journal of biological chemistry 2013
AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer
DG Hardie
Diabetes 2013
Metformin Suppresses Expression of the Selenoprotein P Gene via an AMP-activated Kinase (AMPK)/FoxO3a Pathway in H4IIEC3 Hepatocytes
H Takayama, H Misu, H Iwama, K Chikamoto, Y Saito, K Murao, A Teraguchi, F Lan, A Kikuchi, R Saito, N Tajima, T Shirasaki, S Matsugo, K Miyamoto, S Kaneko, T Takamura
The Journal of biological chemistry 2013
Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice
LB Avery, NN Bumpus
Molecular pharmacology 2013
Metformin Therapy in Diabetes: The Role of Cardioprotection
SE Messaoudi, GA Rongen, NP Riksen
Current Atherosclerosis Reports 2013
Metformin trims fats to restore insulin sensitivity
RJ Shaw
Nature Medicine 2013
Inverse Agonist of Nuclear Receptor ERR  Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis
DK Kim, GT Gang, D Ryu, M Koh, YN Kim, SS Kim, J Park, YH Kim, T Sim, IK Lee, CS Choi, SB Park, CH Lee, SH Koo, HS Choi
Diabetes 2013
Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention
C Pulito, T Sanli, P Rana, P Muti, G Blandino, S Strano
Metabolites 2013
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation
GJ Gowans, SA Hawley, FA Ross, DG Hardie
Cell Metabolism 2013
AMP-activated protein kinase as a key molecular link between metabolism and clockwork
Y Lee, EK Kim
Experimental & molecular medicine 2013
Metabolic targets for cancer therapy
L Galluzzi, O Kepp, MG Heiden, G Kroemer
Nature Reviews Drug Discovery 2013
Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities
A Hernández-Aguilera, A Rull, E Rodríguez-Gallego, M Riera-Borrull, F Luciano-Mateo, J Camps, JA Menéndez, J Joven
Mediators of Inflammation 2013
AMPK Activation through Mitochondrial Regulation Results in Increased Substrate Oxidation and Improved Metabolic Parameters in Models of Diabetes
Y Jenkins, TQ Sun, V Markovtsov, M Foretz, W Li, H Nguyen, Y Li, A Pan, G Uy, L Gross, K Baltgalvis, SL Yung, T Gururaja, T Kinoshita, A Owyang, IJ Smith, K McCaughey, K White, G Godinez, R Alcantara, C Choy, H Ren, R Basile, DJ Sweeny, X Xu, SD Issakani, DC Carroll, DA Goff, SJ Shaw, R Singh, LG Boros, MA Laplante, B Marcotte, R Kohen, B Viollet, A Marette, DG Payan, TM Kinsella, Y Hitoshi
PloS one 2013
Akt activation protects liver cells from apoptosis in rats during acute cold exposure
J Wang, Y Chen, W Zhang, G Zheng, S Meng, H Che, T Ke, J Yang, J Chen, W Luo
International journal of biological sciences 2013
Magnitude and mechanisms of glucose counterregulation following islet transplantation in patients with type 1 diabetes suffering from severe hypoglycaemic episodes
M Ang, C Meyer, MD Brendel, RG Bretzel, T Linn
Diabetologia 2013
Pioglitazone acutely reduces energy metabolism and insulin secretion in rats
J Lamontagne, E Jalbert-Arsenault, E Pepin, ML Peyot, NB Ruderman, CJ Nolan, E Joly, SR Madiraju, V Poitout, M Prentki
Diabetes 2013
Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3′-diindolylmethane in high-fat diet-induced C57BL/6J mice
J Poornima, S Mirunalini
Molecular and Cellular Biochemistry 2013
Insulin Resistance and Environmental Pollutants: Experimental Evidence and Future Perspectives
TL Hectors, C Vanparys, LF van Gaal, PG Jorens, A Covaci, R Blust
Environmental Health Perspectives 2013
AMPKα1: a glucose sensor that controls CD8 T-cell memory
J Rolf, M Zarrouk, DK Finlay, M Foretz, B Viollet, DA Cantrell
European Journal of Immunology 2013
Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells
C Bardeleben, S Sharma, JR Reeve, S Bassilian, P Frost, B Hoang, Y Shi, A Lichtenstein
Molecular cancer therapeutics 2013
AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells
K Takeuchi, Y Morizane, C Kamami-Levy, J Suzuki, M Kayama, W Cai, JW Miller, DG Vavvas
The Journal of biological chemistry 2013
Metformin Is Associated With Survival Benefit in Cancer Patients With Concurrent Type 2 Diabetes: A Systematic Review and Meta-Analysis
M Yin, J Zhou, EJ Gorak, F Quddus
The oncologist 2013
Pharmacogenetics and personalized treatment of type 2 diabetes.
Semiz S, Dujic T, Causevic A
Biochemia Medica 2013
Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle.
Hadad SM, Hardie DG, Appleyard V, Thompson AM
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2013
Dissecting the actions of widely used diabetes drugs.
Unger RH, Berglund ED, Habener JF, Cherrington AD
Nature Medicine 2013
AMP-activated protein kinase, stress responses and cardiovascular diseases
S Wang, P Song, MH Zou
Clinical science (London, England : 1979) 2012
AMPK: a nutrient and energy sensor that maintains energy homeostasis
DG Hardie, FA Ross, SA Hawley
Nature Reviews Molecular Cell Biology 2012
A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts
N Leeuwen, G Nijpels, ML Becker, H Deshmukh, K Zhou, BH Stricker, AG Uitterlinden, A Hofman, E Riet, CN Palmer, B Guigas, PE Slagboom, P Durrington, RA Calle, A Neil, G Hitman, SJ Livingstone, H Colhoun, RR Holman, MI McCarthy, JM Dekker, LM Hart, ER Pearson
Diabetologia 2012
The role of ATM in response to metformin treatment and activation of AMPK
SW Yee, L Chen, KM Giacomini
Nature Genetics 2012
Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line
SJ Fey, K Wrzesinski
Toxicological Sciences 2012
Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells*
S Turban, C Stretton, O Drouin, CJ Green, ML Watson, A Gray, F Ross, L Lantier, B Viollet, DG Hardie, A Marette, HS Hundal
The Journal of biological chemistry 2012
Absence of RIP140 Reveals a Pathway Regulating glut4-Dependent Glucose Uptake in Oxidative Skeletal Muscle through UCP1-Mediated Activation of AMPK
A Fritah, JH Steel, N Parker, E Nikolopoulou, M Christian, D Carling, MG Parker
PloS one 2012
Cellular and molecular mechanisms of metformin: an overview
B Viollet, B Guigas, NS Garcia, J Leclerc, M Foretz, F Andreelli
Clinical science (London, England : 1979) 2012
Cardiovascular effects of antidiabetic agents: focus on blood pressure effects of incretin-based therapies
NJ Brown
Journal of the American Society of Hypertension 2012
AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern
DG Hardie, FA Ross, SA Hawley
Chemistry & Biology 2012
Metformin pathways: pharmacokinetics and pharmacodynamics
L Gong, S Goswami, KM Giacomini, RB Altman, TE Klein
Pharmacogenetics and Genomics 2012
Diabetes treatment in 2025: can scientific advances keep pace with prevalence?
M Shomali
Therapeutic Advances in Endocrinology and Metabolism 2012
Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin
J Kim, E Shon, CS Kim, JS Kim
Experimental Diabetes Research 2012
Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism
M Buler, SM Aatsinki, V Izzi, J Hakkola
PloS one 2012
Pharmacologic Means of Extending Lifespan
DW Lamming
Journal of Clinical & Experimental Pathology 2012
AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart
VG Zaha, LH Young
Circulation research 2012
Metformin Prevents Liver Tumorigenesis by Inhibiting Pathways Driving Hepatic Lipogenesis
K Bhalla, BJ Hwang, RE Dewi, W Twaddel, OG Goloubeva, KK Wong, NK Saxena, S Biswal, GD Girnun
Cancer prevention research (Philadelphia, Pa.) 2012
Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver
CM Hasenour, ED Berglund, DH Wasserman
Molecular and Cellular Endocrinology 2012
Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin
M Zakikhani, M Bazile, S Hashemi, S Javeshghani, D Avizonis, JS Pierre, MN Pollak
PloS one 2012
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
J Gao, W Xie
Trends in Pharmacological Sciences 2012
Mechanisms of current therapies for diabetes mellitus type 2
PM Thulé
AJP Advances in Physiology Education 2012
Interactions between tumor cells and microenvironment in breast cancer: A new opportunity for targeted therapy: Interactions between tumor cells and microenvironment in breast cancer
S Mitra, K Stemke-Hale, GB Mills, S Claerhout
Cancer Science 2012
The insulin and insulin-like growth factor receptor family in neoplasia: an update
M Pollak
Nature Reviews Cancer 2012
The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats
G Barreto-Torres, R Parodi-Rullán, S Javadov
International journal of molecular sciences 2012
Role of AMPK in UVB-induced DNA damage repair and growth control
CL Wu, L Qiang, W Han, M Ming, B Viollet, YY He
Oncogene 2012
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism
P Gut, B Baeza-Raja, O Andersson, L Hasenkamp, J Hsiao, D Hesselson, K Akassoglou, E Verdin, MD Hirschey, DY Stainier
Nature Chemical Biology 2012
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
HA Hirsch, D Iliopoulos, K Struhl
Proceedings of the National Academy of Sciences 2012
Effects of metformin on the regulation of free Fatty acids in insulin resistance: a double-blind, placebo-controlled study
MC Cabezas, JP van Wijk, JW Elte, B Klop
Journal of nutrition and metabolism 2012
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
M Milanski, AP Arruda, A Coope, LM Ignacio-Souza, CE Nunez, EA Roman, T Romanatto, LB Pascoal, AM Caricilli, MA Torsoni, PO Prada, MJ Saad, LA Velloso
Diabetes 2012
Metformin overdose: time to move on
JC Orban, E Fontaine, C Ichai
Critical Care 2012
Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo
N Konstantopoulos, JC Molero, SL McGee, B Spolding, T Connor, M Vries, S Wanyonyi, R Fahey, S Morrison, C Swinton, S Jones, A Cooper, L Garcia-Guerra, VC Foletta, G Krippner, S Andrikopoulos, KR Walder
Diabetes 2012
Organismal carbohydrate and lipid homeostasis
DG Hardie
Cold Spring Harbor perspectives in biology 2012
Cellular responses to the metal-binding properties of metformin
L Logie, J Harthill, K Patel, S Bacon, DL Hamilton, K Macrae, G McDougall, HH Wang, L Xue, H Jiang, K Sakamoto, AR Prescott, G Rena
Diabetes 2012
Maintenance of metabolic homeostasis by Sestrin 2 and 3
JH Lee, AV Budanov, S Talukdar, EJ Park, HL Park, HW Park, G Bandyopadhyay, N Li, M Aghajan, I Jang, AM Wolfe, GA Perkins, MH Ellisman, E Bier, M Scadeng, M Foretz, B Viollet, J Olefsky, M Karin
Cell Metabolism 2012
Metformin effects revisited
P Andújar-Plata, X Pi-Sunyer, B Laferrère
Diabetes Research and Clinical Practice 2012
Roles of AMP-activated protein kinase in Alzheimer's disease.
Cai Z, Yan LJ, Li K, Quazi SH, Zhao B
NeuroMolecular Medicine 2012
The role of ATM in response to metformin treatment and activation of AMPK.
Woods A, Leiper JM, Carling D
Nature Genetics 2012
The role of ATM in response to metformin treatment and activation of AMPK.
Zhou K, Bellenguez C, Sutherland C, Hardie G, Palmer C, Donnelly P, Pearson E
Nature Genetics 2012
Adiponectin-induced changes in gene expression in mouse hepatocytes do not require LKB1-AMPK signaling
Russell Miller, Qingwei Chu, John Le lay, Philipp E. Scherer, Rexford S. Ahima, Klaus Kaestner, Marc Foretz, Benoit Viollet, Morris J Birnbaum
Journal of Clinical Investigation 2011
Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice
M Claret, MA Smith, C Knauf, H Al-Qassab, A Woods, A Heslegrave, K Piipari, JJ Emmanuel, A Colom, P Valet, PD Cani, G Begum, A White, P Mucket, M Peters, K Mizuno, RL Batterham, KP Giese, A Ashworth, R Burcelin, ML Ashford, D Carling, DJ Withers
Diabetes 2011
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury
AS Kim, EJ Miller, TM Wright, J Li, D Qi, K Atsina, V Zaha, K Sakamoto, LH Young
Journal of Molecular and Cellular Cardiology 2011
Hormonal Regulation of Hepatic Glucose Production in Health and Disease
HV Lin, D Accili
Cell Metabolism 2011
Metabolism, migration and memory in cytotoxic T cells
D Finlay, DA Cantrell
Nature Reviews Immunology 2011
Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance
PB de Morentin, CR González, AK Saha, L Martins, C Diéguez, A Vidal-Puig, M Tena-Sempere, M López
Reviews in Endocrine and Metabolic Disorders 2011
AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study
JG Boyle, PJ Logan, GC Jones, M Small, N Sattar, JM Connell, SJ Cleland, IP Salt
Diabetologia 2011
Understanding the benefit of metformin use in cancer treatment
RJ Dowling, PJ Goodwin, V Stambolic
BMC Medicine 2011
The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?
JB Menassol, C Tautou, A Collet, D Chesneau, D Lomet, J Dupont, B Malpaux, RJ Scaramuzzi
BMC neuroscience 2011
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
X Stephenne, M Foretz, N Taleux, GC van der Zon, E Sokal, L Hue, B Viollet, B Guigas
Diabetologia 2011
Does Metformin Work for Everyone? A Genome-wide Association Study for Metformin Response
JC Florez
Current Diabetes Reports 2011
AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
DG Hardie
Genes & development 2011
The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism
MM Mihaylova, RJ Shaw
Nature Cell Biology 2011
Pharmacogenetics in type 2 diabetes: potential implications for clinical practice
C Huang, JC Florez
Genome Medicine 2011
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator
KH Lee, EC Hsu, JH Guh, HC Yang, D Wang, SK Kulp, CL Shapiro, CS Chen
The Journal of biological chemistry 2011
Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin: A Possible Role of HIF-1  Expression and Oxygen Metabolism
Y Takiyama, T Harumi, J Watanabe, Y Fujita, J Honjo, N Shimizu, Y Makino, M Haneda
Diabetes 2011
FoxO6 integrates insulin signaling with gluconeogenesis in the liver
DH Kim, G Perdomo, T Zhang, S Slusher, S Lee, BE Phillips, Y Fan, N Giannoukakis, R Gramignoli, S Strom, S Ringquist, HH Dong
Diabetes 2011
Suppression of FoxO1 Activity by Long-Chain Fatty Acyl Analogs
G Zatara, R Hertz, M Shaked, N Mayorek, E Morad, E Grad, A Cahan, HD Danenberg, TG Unterman, J Bar-Tana
Diabetes 2011
Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase
S Klaus, S Keipert, M Rossmeisl, J Kopecky
Genes & Nutrition 2011
The role of mitochondria in insulin resistance and type 2 diabetes mellitus
J Szendroedi, E Phielix, M Roden
Nature Reviews Endocrinology 2011
Genomics: Drugs, diabetes and cancer
MJ Birnbaum, RJ Shaw
Nature 2011
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
JY Altarejos, M Montminy
Nature Reviews Molecular Cell Biology 2011
AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress
T Williams, J Courchet, B Viollet, JE Brenman, F Polleux
Proceedings of the National Academy of Sciences 2011
The Metabolic Consequences of Hepatic AMP-Kinase Phosphorylation in Rainbow Trout
S Polakof, S Panserat, PM Craig, DJ Martyres, E Plagnes-Juan, S Savari, S Aris-Brosou, TW Moon
PloS one 2011
AMP-activated Protein Kinase Suppresses Matrix Metalloproteinase-9 Expression in Mouse Embryonic Fibroblasts*
Y Morizane, A Thanos, K Takeuchi, Y Murakami, M Kayama, G Trichonas, J Miller, M Foretz, B Viollet, DG Vavvas
The Journal of biological chemistry 2011
The ADMA-Metformin Hypothesis: Linking the Cardiovascular Consequences of the Metabolic Syndrome and Type 2 Diabetes
WH Bestermann
Cardiorenal Medicine 2011
LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice
A Woods, AJ Heslegrave, PJ Muckett, AP Levene, M Clements, M Mobberley, TA Ryder, S Abu-Hayyeh, C Williamson, RD Goldin, A Ashworth, DJ Withers, D Carling
Biochemical Journal 2011
Calorie restriction: is AMPK a key sensor and effector?
C Cantó, J Auwerx
Physiology (Bethesda, Md.) 2011
Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis
R Conti, E Mannucci, P Pessotto, E Tassoni, P Carminati, F Giannessi, A Arduini
Diabetes 2011
Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes.
Ge Y, Zhang Y, Li R, Chen W, Li Y, Chen G
International journal of biological sciences 2011
Reduced cell proliferation and neuroblast differentiation in the dentate gyrus of high fat diet-fed mice are ameliorated by metformin and glimepiride treatment.
Yoo DY, Kim W, Nam SM, Yoo KY, Lee CH, Choi JH, Won MH, Hwang IK, Yoon YS
Neurochemical Research 2011
An energetic tale of AMPK-independent effects of Metformin
Morris J Birnbaum, Russell Miller
Journal of Clinical Investigation 2010
Targeting AMPK for cardiac protection: opportunities and challenges
M Kim, R Tian
Journal of Molecular and Cellular Cardiology 2010
Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistance
E Yamada, TW Lee, JE Pessin, CC Bastie
Future Medicinal Chemistry 2010
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
S Sengupta, TR Peterson, DM Sabatini
Molecular Cell 2010
Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
M Pollak
Cancer prevention research (Philadelphia, Pa.) 2010
Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice.
Maida A, Lamont BJ, Cao X, Drucker DJ
Diabetologia 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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