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Pass the bicarb: the importance of HCO3– for mucin release
Robert C. De Lisle
Robert C. De Lisle
Published August 24, 2009
Citation Information: J Clin Invest. 2009;119(9):2535-2537. https://doi.org/10.1172/JCI40598.
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Pass the bicarb: the importance of HCO3– for mucin release

Abstract

Accumulation of thick, sticky mucus is a hallmark of the genetic disease cystic fibrosis (CF) and has a central role in CF pathophysiology. Mutations in the CF transmembrane regulator (CFTR) ion channel are known to result in abnormally thick and sticky mucus; however, why mucus accumulates in CF is still not completely understood. In this issue of the JCI, Garcia and colleagues show that mucin — the heavily glycosylated protein contained within mucus — requires CFTR and bicarbonate in order to be released from mouse intestine (see the related article beginning on page 2613). The authors propose a model whereby CFTR-mediated bicarbonate secretion must be concurrent with mucin exocytosis for proper mucin release.

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Robert C. De Lisle

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Citations to this article (10)

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Singh V, Johnson K, Yin J, Lee S, Lin R, Yu H, In J, Foulke-Abel J, Zachos NC, Donowitz M, Rong Y 		Cellular and Molecular Gastroenterology and Hepatology 2021
Clinical Presentations of Cystic Fibrosis in Iranian Children
F Motamed, M Moayednia, N Moayednia, MN Sani, F Farahmand, A Khodadad, G Fallahi 		IRAN J PEDIATR 2015
5’-adenosine monophosphate mediated cooling treatment enhances ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) stability in vivo
Y Zhang, WG OBrien, Z Zhao, CC Lee 		Journal of Biomedical Science 2015
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The Cystic Fibrosis of Exocrine Pancreas
M Wilschanski, I Novak 		Cold Spring Harbor Perspectives in Medicine 2013
The role of female hormones on lung function in chronic lung diseases
A Tam, D Morrish, S Wadsworth, D Dorscheid, SF Man, DD Sin 		BMC Women's Health 2011
Embryonic frog epidermis: a model for the study of cell-cell interactions in the development of mucociliary disease
E Dubaissi, N Papalopulu 		Disease models & mechanisms 2011
A new role for bicarbonate secretion in cervico-uterine mucus release
RW Muchekehu, PM Quinton 		The Journal of Physiology 2010

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