Citations to this article

Genomic amplicons target vesicle recycling in breast cancer
Gordon B. Mills, … , Yosef Yarden, Jim C. Norman
Gordon B. Mills, … , Yosef Yarden, Jim C. Norman
Published July 20, 2009
Citation Information: J Clin Invest. 2009;119(8):2123-2127. https://doi.org/10.1172/JCI40256.
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Commentary

Genomic amplicons target vesicle recycling in breast cancer

Abstract

Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a “driver” of the 8p11–12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.

Authors

Gordon B. Mills, Igor Jurisica, Yosef Yarden, Jim C. Norman

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Citations to this article (23)

Title and authors Publication Year
microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane.
Bhattacharya S, Sarker S, Das S, Ahir M, Chattopadhyay S, Ghosh S, Adhikary A 		Apoptosis : an international journal on programmed cell death 2023
TP53 mutations upregulate RCP expression via Sp1/3 to drive lung cancer progression.
Wang C, Zhang S, Ma B, Fu Y, Luo Y 		Oncogene 2022
D-Propranolol Impairs EGFR Trafficking and Destabilizes Mutant p53 Counteracting AKT Signaling and Tumor Malignancy
J Barra, J Cerda-Infante, L Sandoval, P Gajardo-Meneses, JF Henriquez, M Labarca, C Metz, J Venegas, C Retamal, C Oyanadel, J Cancino, A Soza, MA Cuello, JC Roa, VP Montecinos, A Gonzalez 		Cancers 2021
RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin
SR Choe, YN Kim, CG Park, KH Cho, DY Cho, HY Lee 		Experimental & molecular medicine 2018
Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin
BY Jeong, KH Cho, KJ Jeong, YY Park, JM Kim, SY Rha, CG Park, GB Mills, JH Cheong, HY Lee 		Experimental & molecular medicine 2018
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
C Gundry, S Marco, E Rainero, B Miller, E Dornier, L Mitchell, PT Caswell, AD Campbell, A Hogeweg, OJ Sansom, JP Morton, JC Norman 		Nature Communications 2017
Emerging functions of the EGFR in cancer
S Sigismund, D Avanzato, L Lanzetti 		Molecular Oncology 2017
RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin
MH Hwang, KH Cho, KJ Jeong, YY Park, JM Kim, SL Yu, CG Park, GB Mills, HY Lee 		Oncogene 2016
Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT
S Mitra, L Federico, W Zhao, J Dennison, TR Sarkar, F Zhang, V Takiar, KW Cheng, S Mani, JS Lee, GB Mills 		Oncotarget 2016
Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis
SD da Silva, FA Marchi, B Xu, K Bijian, F Alobaid, A Mlynarek, SR Rogatto, M Hier, LP Kowalski, MA Alaoui-Jamali 		Oncotarget 2015
Integrin traffic - the update
ND Franceschi, H Hamidi, J Alanko, P Sahgal, J Ivaska 		Journal of cell science 2015
SYK allelic loss and the role of Syk-regulated genes in breast cancer survival
J Blancato, A Graves, B Rashidi, M Moroni, L Tchobe, M Ozdemirli, B Kallakury, KH Makambi, C Marian, SC Mueller 		PloS one 2014
FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance
IA Ivanova, JF Vermeulen, C Ercan, JM Houthuijzen, FA Saig, EJ Vlug, E der Wall, PJ van Diest, M Vooijs, PW Derksen 		Oncogene 2013
Endocytosis and Cancer
I Mellman, Y Yarden 		Cold Spring Harbor perspectives in biology 2013
Increased expression of Rab coupling protein in squamous cell carcinoma of the head and neck and its clinical significance
Y Dai, Y Liu, D Huang, C Yu, G Cai, L Pi, C Ren, GZ Chen, Y Tian, X Zhang 		Oncology Letters 2012
Rab25 in cancer: a brief update
S Mitra, KW Cheng, GB Mills 		Biochemical Society Transactions 2012
Myoferlin Depletion in Breast Cancer Cells Promotes Mesenchymal to Epithelial Shape Change and Stalls Invasion
R Li, WE 4th, C Mihai, LI Volakis, S Ghadiali, DA Kniss 		PloS one 2012
Regulation of cholesterol biosynthesis and cancer signaling
A Gorin, L Gabitova, I Astsaturov 		Current Opinion in Pharmacology 2012
Rab GTPases implicated in inherited and acquired disorders
S Mitra, KW Cheng, GB Mills 		Seminars in Cell & Developmental Biology 2011
Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression
F Pareja, DA Ferraro, C Rubin, H Cohen-Dvashi, F Zhang, S Aulmann, N Ben-Chetrit, G Pines, R Navon, N Crosetto, W Köstler, S Carvalho, S Lavi, F Schmitt, I Dikic, Z Yakhini, P Sinn, GB Mills, Y Yarden 		Oncogene 2011
Integrative computational biology for cancer research
K Fortney, I Jurisica 		Human Genetics 2011
beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression
L Huck, SM Pontier, DM Zuo, WJ Muller 		Proceedings of the National Academy of Sciences 2010
Integrins: masters and slaves of endocytic transport
PT Caswell, S Vadrevu, JC Norman 		Nature Reviews Molecular Cell Biology 2009

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