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Usage Information

“IF-pathies”: a broad spectrum of intermediate filament–associated diseases
M. Bishr Omary
M. Bishr Omary
Published July 1, 2009
Citation Information: J Clin Invest. 2009;119(7):1756-1762. https://doi.org/10.1172/JCI39894.
View: Text | PDF
Review Series

“IF-pathies”: a broad spectrum of intermediate filament–associated diseases

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Abstract

Intermediate filaments (IFs) are encoded by the largest gene family among the three major cytoskeletal protein groups. Unique IF compliments are expressed in selective cell types, and this expression is reflected in their involvement, upon mutation, as a cause of or predisposition to more than 80 human tissue-specific diseases. This Review Series covers diseases and functional and structural aspects pertaining to IFs and highlights the molecular and functional consequences of IF-associated diseases (IF-pathies). Exciting challenges and opportunities face the IF field, including developing both a better understanding of the pathogenesis of IF-pathies and targeted therapeutic approaches.

Authors

M. Bishr Omary

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 687 111
PDF 77 25
Figure 133 1
Table 170 0
Citation downloads 71 0
Totals 1,138 137
Total Views 1,275
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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