The molecular mechanisms regulating the amount of dietary cholesterol retained in the body as well as the body's ability to selectively exclude other dietary sterols are poorly understood. Studies of the rare autosomal recessively inherited disease sitosterolemia (OMIM 210250) may shed some light on these processes. Patients suffering from this disease appear to hyperabsorb both cholesterol and plant sterols from the intestine. Additionally, there is failure of the liver's ability to preferentially and rapidly excrete these non-cholesterol sterols into bile. Consequently, people who suffer from this disease have very elevated plasma plant sterol levels and develop tendon and tuberous xanthomas, accelerated atherosclerosis, and premature coronary artery disease. Identification of this gene defect may therefore throw light on regulation of net dietary cholesterol absorption and lead to an advancement in the management of this important cardiovascular risk factor. By studying 10 well-characterized families with this disorder, we have localized the genetic defect to chromosome 2p21, between microsatellite markers D2S1788 and D2S1352 (maximum lodscore 4.49, theta = 0.0).
S B Patel, G Salen, H Hidaka, P O Kwiterovich, A F Stalenhoef, T A Miettinen, S M Grundy, M H Lee, J S Rubenstein, M H Polymeropoulos, M J Brownstein
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Blood Phytosterol Concentration and Genetic Variant Associations in a Sample Population
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Nutrients | 2024 |
Phytosterols and Cardiovascular Risk Evaluated against the Background of Phytosterolemia Cases—A German Expert Panel Statement
Windler E, Beil FU, Berthold HK, Gouni-Berthold I, Kassner U, Klose G, Lorkowski S, März W, Parhofer KG, Plat J, Silbernagel G, Steinhagen-Thiessen E, Weingärtner O, Zyriax BC, Lütjohann D |
Nutrients | 2023 |
Clinical and Genetic Analysis of a Family With Sitosterolemia Caused by a Novel ATP-Binding Cassette Subfamily G Member 5 Compound Heterozygous Mutation
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Lipids in Health and Disease | 2022 |
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K Williams, A Segard, GA Graf |
International journal of molecular sciences | 2021 |
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N Khunweeraphong, K Kuchler |
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Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease
XC Jiang |
2020 | |
Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease
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2020 | |
Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease
XC Jiang |
2020 | |
Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease
XC Jiang |
2020 | |
Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease
XC Jiang |
2020 | |
Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease
XC Jiang |
2020 | |
Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease
XC Jiang |
2020 | |
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S Mikhailova, D Ivanoshchuk, O Timoshchenko, E Shakhtshneider |
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X Su, Y Shao, Y Lin, X Zhao, W Zhang, M Jiang, Y Huang, C Zeng, L Liu, X Li |
Journal of Clinical Lipidology | 2019 |
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AA Zein, R Kaur, TO Hussein, GA Graf, JY Lee |
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JM Bastida, ML Girós, R Benito, K Janusz, JM Hernández-Rivas, JR González-Porras |
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D Lütjohann |
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J Plat, S Baumgartner, T Vanmierlo, D Lütjohann, KL Calkins, DG Burrin, G Guthrie, C Thijs, AA Velde, V ACE, R Sverdlov, J Garssen, K Wouters, EA Trautwein, TG Wolfs, C van Gorp, MT Mulder, NP Riksen, AK Groen, RP Mensink |
Progress in Lipid Research | 2019 |
ABCG5 and ABCG8: more than a defense against xenosterols
SB Patel, GA Graf, RE Temel |
Journal of lipid research | 2018 |
Recurrent tendosynovitis as a rare manifestation of a lipid disorder
D Wadsack, H Sattler, ME Kleber, K Eirich, H Scharnagl, G Fauler, W März, TB Grammer |
Journal of Clinical Lipidology | 2018 |
Investigating Sitosterolemia to Understand Lipid Physiology.
Nghiem-Rao TH, Patel SB |
Clinical Lipidology | 2017 |
Plant sterol enriched functional food and atherosclerosis: Plant sterols in functional food
J Köhler, D Teupser, A Elsässer, O Weingärtner |
British Journal of Pharmacology | 2017 |
Investigating Sitosterolemia to Understand Lipid Physiology
T Hang Nghiem-Rao, Shailendra B Patel |
Clinical Lipidology | 2017 |
Cryptogenic Cirrhosis and Sitosterolemia: A Treatable Disease If Identified but Fatal If Missed
F Bazerbachi, EE Conboy, T Mounajjed, KD Watt, D Babovic-Vuksanovic, SB Patel, PS Kamath |
ANN HEPATOL | 2017 |
Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice: Wang et al
HH Wang, X Li, SB Patel, DQ Wang |
Hepatology | 2016 |
Cardiovascular Diseases
RM Dumitru |
Cardiovascular diseases | 2016 |
Bengal macrothrombocytopenia is not totally an innocuous condition
S Ali, S Shetty, K Ghosh |
Blood Cells, Molecules, and Diseases | 2016 |
Inborn Metabolic Diseases
JM Saudubray, MR Baumgartner, J Walter |
Inborn Metabolic Diseases | 2016 |
Progress in understanding the diagnosis and molecular genetics of macrothrombocytopenias
R Favier, H Raslova |
British Journal of Haematology | 2015 |
Plant Sterols, Stanols, and Sitosterolemia.
Ajagbe BO, Othman RA, Myrie SB |
Journal of AOAC International | 2015 |
20-Year-Old Amish Woman With Abdominal Pain, Retroperitoneal Mass, and Hyperlipidemia: Clinicopathologic Conference
XD Ruiz, MC Levesque, SR Modi, GD Mock, KP Liang |
Arthritis Care & Research | 2015 |
Kinetics of phytosterol metabolism in neonates receiving parenteral nutrition
TH Nghiem-Rao, I Tunc, AM Mavis, Y Cao, EM Polzin, MF Firary, X Wang, PM Simpson, SB Patel |
Pediatric Research | 2015 |
PanVascular Medicine
AN Rizzo, DR Fraidenburg, JX Yuan |
PanVascular Medicine | 2015 |
Dyslipidemias: Pathophysiology, Evaluation and Management
A Garg |
2015 | |
High-density lipoprotein and atherosclerosis: Roles of lipid transporters
Y Uehara |
2014 | |
Sitosterolemia: Diagnosis, Investigation, and Management
JC Escolà-Gil, H Quesada, J Julve, JM Martín-Campos, L Cedó, F Blanco-Vaca |
Current Atherosclerosis Reports | 2014 |
Recent advances in understanding the STSL locus and ABCG5/ABCG8 biology:
SB Patel |
Current Opinion in Lipidology | 2014 |
Cerebrotendinous xanthomatosis: a comprehensive review of pathogenesis, clinical manifestations, diagnosis, and management
S Nie, G Chen, X Cao, Y Zhang |
Orphanet Journal of Rare Diseases | 2014 |
Sitosterolemia en paciente de 2 años con xantomas y alteraciones hematológicas
FJ Rodriguez, MJ Barcina, IM de Lizarduy, CF Ramos, ES Gonzalez |
Anales de Pediatría | 2014 |
Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia
T Kanaji, S Kanaji, RR Montgomery, SB Patel, PJ Newman |
Blood | 2013 |
The ABCG8 G574R Variant, Serum Plant Sterol Levels, and Cardiovascular Disease Risk in the Old Order Amish
RB Horenstein, BD Mitchell, WS Post, D Lütjohann, K von Bergmann, KA Ryan, M Terrin, AR Shuldiner, NI Steinle |
Arteriosclerosis, thrombosis, and vascular biology | 2013 |
Bioactive Food as Dietary Interventions for Cardiovascular Disease
H Hwang, JP Konhilas |
Bioactive Food as Dietary Interventions for Cardiovascular Disease | 2013 |
Genes involved in type 1 diabetes: an update
M Bakay, R Pandey, H Hakonarson |
Genes & development | 2013 |
Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice[S]
C Solca, GS Tint, SB Patel |
Journal of lipid research | 2013 |
Inhibition of Cholesterol Absorption: Targeting the Intestine
SD Lee, P Gershkovich, JW Darlington, KM Wasan |
Pharmaceutical Research | 2012 |
Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice
C Solca, GS Tint, SB Patel |
Journal of lipid research | 2012 |
Hepatobiliary transport in health and disease
J Chan, JL VandeBerg |
Clinical Lipidology | 2012 |
ABC Transporters in Human Disease
K Moitra |
Colloquium Series on The Genetic Basis of Human Disease | 2012 |
A Phytosterolemia Patient Presenting Exclusively with Macrothrombocytopenia and Stomatocytic Hemolysis
G Wang, Z Wang, J Liang, L Cao, X Bai, C Ruan |
Acta Haematologica | 2011 |
Canalicular ABC transporters and liver disease
M Nicolaou, EJ Andress, JK Zolnerciks, PH Dixon, C Williamson, KJ Linton |
The Journal of Pathology | 2011 |
Rare thesaurismosis and xanthomatosis
G Chalès, G Coiffier, P Guggenbuhl |
Best Practice & Research Clinical Rheumatology | 2011 |
Henry's Clinical Diagnosis and Management by Laboratory Methods
JL Miller, AK Rao |
Henry's Clinical Diagnosis and Management by Laboratory Methods | 2011 |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
Cholesterol Binding and Cholesterol Transport Proteins:
JR Harris |
2010 | |
ABC transporters, atherosclerosis and inflammation
ML Fitzgerald, Z Mujawar, N Tamehiro |
Atherosclerosis | 2010 |
Phytosterols and phytosterolemia: gene–diet interactions
MC Izar, DM Tegani, SH Kasmas, FA Fonseca |
Genes & Nutrition | 2010 |
Clinical observations, molecular genetic analysis, and treatment of sitosterolemia in infants and children
DM Niu, KW Chong, JH Hsu, TJ Wu, HC Yu, CH Huang, MY Lo, CF Kwok, LE Kratz, LT Ho |
Journal of Inherited Metabolic Disease | 2010 |
Current Therapy for Patients with Sitosterolemia –Effect of Ezetimibe on Plant Sterol Metabolism
K Tsubakio-Yamamoto, M Nishida, Y Nakagawa-Toyama, D Masuda, T Ohama, S Yamashita |
Journal of Atherosclerosis and Thrombosis | 2010 |
Sleisenger and Fordtran's Gastrointestinal and Liver Disease
C Högenauer, HF Hammer |
Sleisenger and Fordtran's Gastrointestinal and Liver Disease | 2010 |
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MC Izar, VA Machado, FA Fonseca |
The Application of Clinical Genetics | 2010 |
Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8)
JM Brown, L Yu |
Immunology, endocrine & metabolic agents in medicinal chemistry | 2009 |
Transport of lipids by ABC proteins: Interactions and implications for cellular toxicity, viability and function
IL Aye, AT Singh, JA Keelan |
Chemico-Biological Interactions | 2009 |
Plant sterols and stanols: their role in health and disease
SB Patel |
Journal of Clinical Lipidology | 2008 |
Cholesterol and non-cholesterol sterol transporters: ABCG5, ABCG8 and NPC1L1: a review
S Kidambi, SB Patel |
Xenobiotica | 2008 |
Protein Science Encyclopedia
G Schmitz, T Langmann |
Protein Science Encyclopedia | 2008 |
Long-term efficacy and safety of ezetimibe 10 mg in patients with homozygous sitosterolemia: a 2-year, open-label extension study
D Lütjohann, KV Bergmann, W Sirah, G Macdonell, AO Johnson-Levonas, A Shah, J Lin, A Sapre, T Musliner |
International Journal of Clinical Practice | 2008 |
Efficacy and safety of ezetimibe 40 mg vs. ezetimibe 10 mg in the treatment of patients with homozygous sitosterolaemia
T Musliner, D Cselovszky, W Sirah, CM Sisk, A Sapre, G Salen, D Lütjohann, KV Bergmann |
International Journal of Clinical Practice | 2008 |
Genetic variation and atherosclerosis
E Biros, M Karan, J Golledge |
Current genomics | 2008 |
Safety assessment of common foods enriched with natural nonesterified plant sterols
J Tuomilehto, MJ Tikkanen, P Högström, S Keinänen-Kiukaanniemi, V Piironen, J Toivo, JT Salonen, K Nyyssönen, UH Stenman, H Alfthan, H Karppanen |
European Journal of Clinical Nutrition | 2008 |
Therapeutic Lipidology
MH Davidson, PP Toth, KC Maki, AM Gotto |
2008 | |
Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion inAbcg8−/− mice
HH Wang, SB Patel, MC Carey, DQ Wang |
Hepatology | 2007 |
Sitosterol xanthomatosis
SS Guirado, JS Conejo-Mir, MA Muñoz, JB Wite, LR Fernandez-Freire, JV Ortíz |
Journal of the European Academy of Dermatology and Venereology | 2007 |
Regulation of Intestinal Cholesterol Absorption
DQ Wang |
Annual Review of Physiology | 2007 |
Beta-sitosterolaemia: a new nonsense mutation in the ABCG5 gene
L Mannucci, O Guardamagna, P Bertucci, L Pisciotta, L Liberatoscioli, S Bertolini, C Irace, A Gnasso, G Federici, C Cortese |
European Journal of Clinical Investigation | 2007 |
Cholesterol and Plant Sterol Efflux from Cultured Intestinal Epithelial Cells Is Mediated by ATP-Binding Cassette Transporters
S TACHIBANA, M HIRANO, T HIRATA, M MATSUO, I IKEDA, K UEDA, R SATO |
Bioscience, Biotechnology, and Biochemistry | 2007 |
HDL Cholesterol: Physiology, Pathophysiology, and Management
JJ Link, A Rohatgi, JA de Lemos |
Current Problems in Cardiology | 2007 |
Liver Transplantation in a Patient With Sitosterolemia and Cirrhosis
TA Miettinen, EL Klett, H Gylling, H Isoniemi, SB Patel |
Gastroenterology | 2006 |
Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols
SE Hazard, SB Patel |
Pflügers Archiv - European Journal of Physiology | 2006 |
A detailed Hapmap of the Sitosterolemia locus spanning 69 kb; differences between Caucasians and African-Americans
B Pandit, GS Ahn, SE Hazard, D Gordon, SB Patel |
BMC Medical Genetics | 2006 |
Tracking the dietary cholesterol molecule
S Kidambi, C Solca, S Patel |
Future Lipidology | 2006 |
Phytosterols and vascular disease
MD Patel, PD Thompson |
Atherosclerosis | 2006 |
Intestinal Cholesterol Absorption Inhibitor Ezetimibe Added to Cholestyramine for Sitosterolemia and Xanthomatosis
G Salen, T Starc, CM Sisk, SB Patel |
Gastroenterology | 2006 |
Physiology of the Gastrointestinal Tract
DJ Drucker |
Physiology of the Gastrointestinal Tract | 2006 |
Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study
S Pinedo, MN Vissers, K Bergmann, K Elharchaoui, D Lütjohann, R Luben, NJ Wareham, JJ Kastelein, KT Khaw, SM Boekholdt |
Journal of lipid research | 2006 |
Temporal and spatial variations of lipid droplets during adipocyte division and differentiation
M Nagayama, T Uchida, K Gohara |
Journal of lipid research | 2006 |
Molecular mechanisms of cholesterol absorption and transport in the intestine
DY Hui, PN Howles |
Seminars in Cell & Developmental Biology | 2005 |
Sitosterolaemia in Switzerland: molecular genetics links the US Amish-Mennonites to their European roots
C Solcà, Z Stanga, B Pandit, P Diem, J Greeve, SB Patel |
Clinical Genetics | 2005 |
The missense mutation in Abcg5 gene in spontaneously hypertensive rats (SHR) segregates with phytosterolemia but not hypertension
J Chen, A Batta, S Zheng, WR Fitzgibbon, ME Ullian, H Yu, P Tso, G Salen, SB Patel |
BMC genetics | 2005 |
Sterol transporters: targets of natural sterols and new lipid lowering drugs
T Sudhop, D Lütjohann, K Bergmann |
Pharmacology & Therapeutics | 2005 |
Cholesterol and Plant Sterol Absorption: Recent Insights
K Bergmann, T Sudhop, D Lütjohann |
The American Journal of Cardiology | 2005 |
Atherosclerosis: Diet and Drugs
A von Eckardstein |
2005 | |
Principles of Molecular Cardiology
MS Runge, C Patterson |
2005 | |
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
EL Klett, K Lu, A Kosters, E Vink, MH Lee, M Altenburg, S Shefer, AK Batta, H Yu, J Chen, R Klein, N Looije, R Oude-Elferink, AK Groen, N Maeda, G Salen, SB Patel |
BMC Medicine | 2004 |
Sitosterolemia--a rare disease. Are elevated plant sterols an additional risk factor?
Sudhop T, von Bergmann K |
2004 | |
Lipid lowering activity of drugs affecting cholesterol absorption
GD Norata, AL Catapano |
Nutrition, Metabolism and Cardiovascular Diseases | 2004 |
Plant sterols: factors affecting their efficacy and safety as functional food ingredients
A Berger, PJ Jones, SS Abumweis |
Lipids in Health and Disease | 2004 |
A genome-wide scan of serum lipid levels in the Old Order Amish
TI Pollin, WC Hsueh, NI Steinle, S Snitker, AR Shuldiner, BD Mitchell |
Atherosclerosis | 2004 |
Sitosterolemia; of mice and man
SB Patel, EL Klett, GS Anh, H Yu, J Chen, B Pandit, MH Lee, G Salen |
International Congress Series | 2004 |
Phenotypic heterogeneity of sitosterolemia
J Wang, T Joy, D Mymin, J Frohlich, RA Hegele |
Journal of lipid research | 2004 |
The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats
H Yu, B Pandit, E Klett, MH Lee, K Lu, K Helou, I Ikeda, N Egashira, M Sato, R Klein, A Batta, G Salen, SB Patel |
BMC Cardiovascular Disorders | 2003 |
Genetic defenses against noncholesterol sterols
EL Klett, S Patel |
Current Opinion in Lipidology | 2003 |
Genetic defenses against noncholesterol sterols
EL Klett, S Patel |
Current Opinion in Lipidology | 2003 |
ABC Proteins
PA Rea, R Sánchez-Fernández, S Chen, M Peng, M Klein, M Geisler, E Martinoia |
ABC Proteins | 2003 |
Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins
TA Miettinen, H Gylling, N Lindbohm, TE Miettinen, RA Rajaratnam, H Relas |
Journal of Laboratory and Clinical Medicine | 2003 |
Genetic regulation of cholesterol absorption and plasma plant sterol levels: commonalities and differences
E Sehayek |
Journal of lipid research | 2003 |
Lexikon der Syndrome und Fehlbildungen
R Witkowski, O Prokop, E Ullrich, G Thiel |
2003 | |
Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross
E Sehayek, EM Duncan, D Lutjohann, KV Bergmann, JG Ono, AK Batta, G Salen, JL Breslow |
Proceedings of the National Academy of Sciences | 2002 |
Genetic Defenses against Hypercholesterolemia
H Hobbs, G Graf, L Yu, K Wilund, J Cohen |
Cold Spring Harbor Symposia on Quantitative Biology | 2002 |
Sitosterolemia
G Salen, S Patel, AK Batta |
Cardiovascular Drug Reviews | 2002 |
Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8
K Lu, MH Lee, H Yu, Y Zhou, SA Sandell, G Salen, SB Patel |
Journal of lipid research | 2002 |
Functional analysis of candidate ABC transporter proteins for sitosterol transport
C Albrecht, JI Elliott, A Sardini, T Litman, B Stieger, PJ Meier, CF Higgins |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 2002 |
Genetic defects in hepatobiliary transport
Ronald Oude Elferink, Albert K Groen |
Biochimica et Biophysica Acta | 2002 |
Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
K Lu, MH Lee, S Hazard, A Brooks-Wilson, H Hidaka, H Kojima, L Ose, AF Stalenhoef, T Mietinnen, I Bjorkhem, E Bruckert, A Pandya, HB Brewer, G Salen, M Dean, A Srivastava, SB Patel |
The American Journal of Human Genetics | 2001 |
Genetic basis of sitosterolemia
MH Lee, K Lu, SB Patel |
Current Opinion in Lipidology | 2001 |
Dietary cholesterol absorption; more than just bile
K Lu, MH Lee, SB Patel |
Trends in Endocrinology & Metabolism | 2001 |
An Immune Defect Causing Dominant Chronic Mucocutaneous Candidiasis and Thyroid Disease Maps to Chromosome 2p in a Single Family
TP Atkinson, AA Schäffer, B Grimbacher, HW Schroeder, C Woellner, CS Zerbe, JM Puck |
The American Journal of Human Genetics | 2001 |
Monogenic Dyslipidemias: Window on Determinants of Plasma Lipoprotein Metabolism
RA Hegele |
The American Journal of Human Genetics | 2001 |
High-resolution physical and transcript map of human chromosome 2p21 containing the sitosterolaemia locus
K Lu, MH Lee, JD Carpten, M Sekhon, SB Patel |
European journal of human genetics : EJHG | 2001 |
Fine mapping of a gene responsible for regulating dietary cholesterol absorption; founder effects underlie cases of phytosterolaemia in multiple communities
MH Lee, D Gordon, J Ott, K Lu, L Ose, T Miettinen, H Gylling, AF Stalenhoef, A Pandya, H Hidaka, B Brewer, H Kojima, N Sakuma, R Pegoraro, G Salen, SB Patel |
European journal of human genetics : EJHG | 2001 |
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
MH Lee, K Lu, S Hazard, H Yu, S Shulenin, H Hidaka, H Kojima, R Allikmets, N Sakuma, R Pegoraro, AK Srivastava, G Salen, M Dean, SB Patel |
Nature Genetics | 2001 |
A review of clinical trials in dietary interventions to decrease the incidence of coronary artery disease
H Gylling, TA Miettinen |
Current controlled trials in cardiovascular medicine | 2001 |
Los fitosteroles, el colesterol y la prevención de las enfermedades cardiovasculares
I Plaza |
Clínica e Investigación en Arteriosclerosis | 2001 |
Safety and Tolerability of Esterified Phytosterols Administered in Reduced-Fat Spread and Salad Dressing to Healthy Adult Men and Women
MH Davidson, KC Maki, DM Umporowicz, KA Ingram, MR Dicklin, E Schaefer, RW Lane, JR McNamara, JD Ribaya-Mercado, G Perrone, SJ Robins, WC Franke |
Journal of the American College of Nutrition | 2001 |
Phytosterols-what plant breeders should focus on
TA Miettinen |
Journal of the Science of Food and Agriculture | 2001 |
Biomarkers in disease and health
F Branca, AB Hanley, B Pool-Zobel, H Verhagen |
British Journal of Nutrition | 2001 |
Effect of plant sterol-enriched margarine on plasma lipids and sterols in subjects heterozygous for phytosterolaemia
AF Stalenhoef, M Hectors, PN Demacker |
Journal of Internal Medicine | 2001 |
Lipid responses to plant-sterol-enriched reduced-fat spreads incorporated into a National Cholesterol Education Program Step I diet
KC Maki, MH Davidson, DM Umporowicz, EJ Schaefer, MR Dicklin, KA Ingram, S Chen, JR McNamara, BW Gebhart, JD Ribaya-Mercado, G Perrone, SJ Robins, WC Franke |
The American journal of clinical nutrition | 2001 |
Genetic analysis of phytosterolaemia
M Togo, T Toda, LA Nguyen, S Kubota, K Tsukamoto, H Satoh, M Hara, N Iso-o, H Noto, S Kimura, K Nakahara, Y Seyama, Y Hashimoto |
Journal of Inherited Metabolic Disease | 2001 |
Role of ABCG1 and other ABCG family members in lipid metabolism
G Schmitz, T Langmann, S Heimerl |
Journal of lipid research | 2001 |
Genetic factors at the enterocyte level account for variations inintestinal cholesterol absorption efficiency among inbred strains of mice
DQ Wang, B Paigen, MC Carey |
Journal of lipid research | 2001 |
Genetic basis of sitosterolemia.
Lee MH, Lu K, Patel SB |
Current Opinion in Lipidology | 2001 |
Plant sterols: biosynthesis, biological function and their importance to human nutrition
V Piironen, DG Lindsay, TA Miettinen, J Toivo, AM Lampi |
Journal of the Science of Food and Agriculture | 2000 |
Tuberous Xanthomas in Sitosterolemia
M Alam, MC Garzon, G Salen, TJ Starc |
Pediatric Dermatology | 2000 |
3-Hydroxy-3-methylglutaryl-coenzyme A reductase activity is inhibited by cholesterol and up-regulated by sitosterol in sitosterolemic fibroblasts
A Honda, G Salen, M Honda, AK Batta, GS Tint, G Xu, TS Chen, N Tanaka, S Shefer |
Journal of Laboratory and Clinical Medicine | 2000 |
Intestinal absorption of cholesterol is mediated by a saturable, inhibitable transporter
M Hernandez, J Montenegro, M Steiner, D Kim, C Sparrow, PA Detmers, SD Wright, YS Chao |
Biochimica et Biophysica Acta | 2000 |
Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters
KE Berge, H Tian, GA Graf, L Yu, NV Grishin, J Schultz, P Kwiterovich, B Shan, R Barnes, HH Hobbs |
Science | 2000 |
Noncholesterol Sterols and Cholesterol Lowering by Long-Term Simvastatin Treatment in Coronary Patients: Relation to Basal Serum Cholestanol
TA Miettinen, TE Strandberg, H Gylling |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
An Absorbing Study of Cholesterol
H Allayee, BA Laffitte, AJ Lusis |
Science | 2000 |
Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three control subjects
G Salen, G Xu, GS Tint, AK Batta, S Shefer |
Journal of lipid research | 2000 |
Intestinal cholesterol absorption
PA Dawson, LL Rudel |
Current Opinion in Lipidology | 1999 |
Clinical lipidology at the end of the millennium
GR Thompson, PJ Barter |
Current Opinion in Lipidology | 1999 |
ROLE OF THE ENTEROHEPATIC CIRCULATION OF BILE SALTS IN LIPOPROTEIN METABOLISM
AD Cooper |
Gastroenterology Clinics of North America | 1999 |
Nutrient absorption:
DF Nutting, NS Kumar, RJ st. Hilaire, CM Mansbach |
Current Opinion in Gastroenterology | 1999 |
Molecular Pathogenesis of Cholestasis
FH Epstein, M Trauner, PJ Meier, JL Boyer |
New England Journal of Medicine | 1998 |