The peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor implicated in the control of cellular lipid utilization. To test the hypothesis that PPARalpha is activated as a component of the cellular lipid homeostatic response, the expression of PPARalpha target genes was characterized in response to a perturbation in cellular lipid oxidative flux caused by pharmacologic inhibition of mitochondrial fatty acid import. Inhibition of fatty acid oxidative flux caused a feedback induction of PPARalpha target genes encoding fatty acid oxidation enzymes in liver and heart. In mice lacking PPARalpha (PPARalpha-/-), inhibition of cellular fatty acid flux caused massive hepatic and cardiac lipid accumulation, hypoglycemia, and death in 100% of male, but only 25% of female PPARalpha-/- mice. The metabolic phenotype of male PPARalpha-/- mice was rescued by a 2-wk pretreatment with beta-estradiol. These results demonstrate a pivotal role for PPARalpha in lipid and glucose homeostasis in vivo and implicate estrogen signaling pathways in the regulation of cardiac and hepatic lipid metabolism.
F Djouadi, C J Weinheimer, J E Saffitz, C Pitchford, J Bastin, F J Gonzalez, D P Kelly
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Sex and Gender Differences in Pharmacology
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2012 | |
Sex and Gender Differences in Pharmacology
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2012 | |
Sex and Gender Differences in Pharmacology
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2012 | |
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L Gan, W Jiang, YF Xiao, L Deng, LD Gu, ZY Guo, ZC Zhou, D Wu, HB Xin |
Life Sciences | 2011 |
Red Clover Extract Ameliorates Dyslipidemia in Streptozotocin-induced Diabetic C57BL/6 Mice by Activating Hepatic PPARα : RED CLOVER EXTRACT AND DIABETIC DYSLIPIDEMIA
L Qiu, H Ye, L Chen, Y Hong, F Zhong, T Zhang |
Phytotherapy Research | 2011 |
Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-α and Ameliorates Hepatosteatosis in Diabetic db/db Mice
L Qiu, J Lin, F Xu, Y Gao, C Zhang, Y Liu, Y Luo, JY Yang |
Experimental Diabetes Research | 2011 |
DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle
L Liu, S Yu, RS Khan, GP Ables, KG Bharadwaj, Y Hu, LA Huggins, JW Eriksson, LK Buckett, AV Turnbull, HN Ginsberg, WS Blaner, LS Huang, IJ Goldberg |
Journal of lipid research | 2011 |
ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor α Expression in Pancreatic β-Cells
M Boergesen, LC Poulsen, SF Schmidt, F Frigerio, P Maechler, S Mandrup |
The Journal of biological chemistry | 2011 |
Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart
P Wang, J Liu, Y Li, S Wu, J Luo, H Yang, R Subbiah, J Chatham, O Zhelyabovska, Q Yang |
Circulation research | 2010 |
What we know and do not know about sex and cardiac disease
JP Konhilas |
Journal of biomedicine & biotechnology | 2010 |
A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes
S Cresci, JM Huss, AL Beitelshees, PG Jones, MR Minton, GW Dorn, DP Kelly, JA Spertus, HL McLeod |
PloS one | 2010 |
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways
Y Lecarpentier, V Claes, JL Hébert |
PPAR Research | 2010 |
Sex-different hepatic glycogen content and glucose output in rats
C Gustavsson, K Yassin, E Wahlström, L Cheung, J Lindberg, K Brismar, CG Östenson, G Norstedt, P Tollet-Egnell |
BMC Biochemistry | 2010 |
A Maternal “Junk Food” Diet in Pregnancy and Lactation Promotes Nonalcoholic Fatty Liver Disease in Rat Offspring
SA Bayol, BH Simbi, RC Fowkes, NC Stickland |
Endocrinology | 2010 |
Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity
D Zadravec, A Brolinson, RM Fisher, C Carneheim, RI Csikasz, J Bertrand-Michel, J Borén, H Guillou, M Rudling, A Jacobsson |
The FASEB Journal | 2010 |
Conditional PPARγ knockout from cardiomyocytes of adult mice impairs myocardial fatty acid utilization and cardiac function
J Luo, S Wu, J Liu, Y Li, H Yang, T Kim, O Zhelyabovska, G Ding, Y Zhou, Y Yang, Q Yang |
American journal of translational research | 2010 |
Fulminant hepatic failure requiring liver transplantation in 22q13.3 deletion syndrome
O Bartsch, E Schneider, N Damatova, R Weis, M Tufano, R Iorio, A Ahmed, V Beyer, U Zechner, T Haaf |
American Journal of Medical Genetics Part A | 2010 |
Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride
P Chen, X Kakan, J Zhang |
FEBS Letters | 2010 |
A PPARα Promoter Variant Impairs ERR-Dependent Transactivation and Decreases Mortality after Acute Coronary Ischemia in Patients with Diabetes
S Cresci, JM Huss, AL Beitelshees, PG Jones, MR Minton, GW Dorn, DP Kelly, JA Spertus, HL McLeod, A Leri |
PloS one | 2010 |
Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERα-deficient mice
V Ribas, MT Nguyen, DC Henstridge, AK Nguyen, SW Beaven, MJ Watt, AL Hevener |
American journal of physiology. Endocrinology and metabolism | 2010 |
CYP2J2 expression activates PPARalpha in vitro and in vivo
David Bishop-Bailey, Mary C. Sugden, Darryl C. Zeldin, Jessica A. Wray, Gemma K. Greenwood, Salma Samsuddin, Laura M. Degraff, J. Alyce Bradbury, Derek W. Gilroy, Mark J. Holness, Timothy D. Warner |
PloS one | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
PPARs and the Cardiovascular System
M Hamblin, L Chang, Y Fan, J Zhang, YE Chen |
Antioxidants & Redox Signaling | 2009 |
Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice
V Ribas, MT Nguyen, DC Henstridge, AK Nguyen, SW Beaven, MJ Watt, AL Hevener |
American journal of physiology. Endocrinology and metabolism | 2009 |
A potential link between peroxisome proliferator-activated receptor signalling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy
F Djouadi, Y Lecarpentier, JL Hebert, P Charron, J Bastin, C Coirault |
Cardiovascular Research | 2009 |
Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm
KR Feingold, A Moser, SM Patzek, JK Shigenaga, C Grunfeld |
Journal of lipid research | 2009 |
Hepatic phenotype of liver fatty acid binding protein gene-ablated mice
GG Martin, BP Atshaves, H Huang, AL McIntosh, BJ Williams, PJ Pai, DH Russell, AB Kier, F Schroeder |
American journal of physiology. Gastrointestinal and liver physiology | 2009 |
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A
LC Enns, JF Morton, RS Mangalindan, GS McKnight, MW Schwartz, MR Kaeberlein, BK Kennedy, PS Rabinovitch, WC Ladiges |
The journals of gerontology. Series A, Biological sciences and medical sciences | 2009 |
Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults
EM Urbina, P Khoury, LJ Martin, D D'Alessio, LM Dolan |
International Journal of Obesity | 2009 |
Sex differences in global mRNA content of human skeletal muscle
AC Maher, MH Fu, RJ Isfort, AR Varbanov, XA Qu, MA Tarnopolsky |
PloS one | 2009 |
Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse
HJ Atherton, MK Gulston, NJ Bailey, KK Cheng, W Zhang, K Clarke, JL Griffin |
Molecular Systems Biology | 2009 |
Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock
X Yang, YK Zhang, N Esterly, CD Klaassen, YJ Wan |
Journal of Biochemistry | 2009 |
High Dietary Fat Exacerbates Weight Gain and Obesity in Female Liver Fatty Acid Binding Protein Gene-Ablated Mice
BP Atshaves, AL McIntosh, SM Storey, KK Landrock, AB Kier, F Schroeder |
Lipids | 2009 |
Hepatic lipid metabolism response to dietary fatty acids is differently modulated by PPARα in male and female mice
A Morise, C Thomas, JF Landrier, P Besnard, D Hermier |
European Journal of Nutrition | 2009 |
Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease
E Robinson, DJ Grieve |
Pharmacology & Therapeutics | 2009 |
Sex-Based Cardiac Physiology
ED Luczak, LA Leinwand |
Annual Review of Physiology | 2009 |
Novel plasma phospholipid biomarkers of autism: Mitochondrial dysfunction as a putative causative mechanism
É Pastural, S Ritchie, Y Lu, W Jin, A Kavianpour, KK Su-Myat, D Heath, PL Wood, M Fisk, DB Goodenowe |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2009 |
The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPARα In Vitro and In Vivo
JA Wray, MC Sugden, DC Zeldin, GK Greenwood, S Samsuddin, L Miller-Degraff, JA Bradbury, MJ Holness, TD Warner, D Bishop-Bailey, D Tomé |
PloS one | 2009 |
Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm
KR Feingold, A Moser, SM Patzek, JK Shigenaga, C Grunfeld |
Journal of lipid research | 2009 |
Hepatic phenotype of liver fatty acid binding protein gene-ablated mice
GG Martin, BP Atshaves, H Huang, AL McIntosh, BJ Williams, PJ Pai, DH Russell, AB Kier, F Schroeder |
AJP Gastrointestinal and Liver Physiology | 2009 |
Recent Developments in Liver Pathology
BC Yan, JA Hart |
Archives of pathology & laboratory medicine | 2009 |
Sex-specific pathways in early cardiac response to pressure overload in mice
H Witt, C Schubert, J Jaekel, D Fliegner, A Penkalla, K Tiemann, J Stypmann, S Roepcke, S Brokat, S Mahmoodzadeh, E Brozova, MM Davidson, PR Noppinger, C Grohé, V Regitz-Zagrosek |
Journal of Molecular Medicine | 2008 |
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
JJ Lehman, S Boudina, NH Banke, N Sambandam, X Han, DM Young, TC Leone, RW Gross, ED Lewandowski, ED Abel, DP Kelly |
American journal of physiology. Heart and circulatory physiology | 2008 |
[The binuclear iron site of the membrane-bound methane hydroxylase from Methylococcus capsulatus (strain M)]
PG Isaacson, MQ Du |
Bioorganicheskaia khimiia | 2008 |
PPARs as therapeutic targets for correction of inborn mitochondrial fatty acid oxidation disorders
F Djouadi, J Bastin |
Journal of Inherited Metabolic Disease | 2008 |
Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice
G Bryzgalova, L Lundholm, N Portwood, JA Gustafsson, A Khan, S Efendic, K Dahlman-Wright |
American journal of physiology. Endocrinology and metabolism | 2008 |
Peroxisome proliferator-activated receptor-alpha modulates insulin gene transcription factors and inflammation in adipose tissues in mice
A Yessoufou, JM Atègbo, E Attakpa, A Hichami, K Moutairou, KL Dramane, NA Khan |
Molecular and Cellular Biochemistry | 2008 |
PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease
S Cresci |
PPAR Research | 2008 |
Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation
A Akki, K Smith, AM Seymour |
Molecular and Cellular Biochemistry | 2008 |
Sex differences in the control of glucose homeostasis
E Blaak |
Current Opinion in Clinical Nutrition and Metabolic Care | 2008 |
Chronic palmitate exposure inhibits AMPKα and decreases glucose-stimulated insulin secretion from β-cells: modulation by fenofibrate
Y SUN, M REN, G GAO, B GONG, W XIN, H GUO, X ZHANG, L GAO, J ZHAO |
Acta Pharmacologica Sinica | 2008 |
Enhanced detection of genetic association of hypertensive heart disease by analysis of latent phenotypes
CC Gu, HR Flores, L las Fuentes, VG Dávila-Román |
Genetic Epidemiology | 2008 |
Muscle Physiology in Healthy Men and Women and Those with Metabolic Myopathies
MC Devries, MA Tarnopolsky |
Neurologic Clinics | 2008 |
The PPAR trio: Regulators of myocardial energy metabolism in health and disease
JA Madrazo, DP Kelly |
Journal of Molecular and Cellular Cardiology | 2008 |
Modulación del PPARα por agentes farmacológicos y naturales y sus implicaciones metabólicas
MI Panadero, MC González, E Herrera, C Bocos |
Clínica e Investigación en Arteriosclerosis | 2008 |
[The binuclear iron site of the membrane-bound methane hydroxylase from Methylococcus capsulatus (strain M)]
PG Isaacson, MQ Du |
Bioorganicheskaia khimiia | 2008 |
A Natural Polymorphism in Peroxisome Proliferator-Activated Receptor-α Hinge Region Attenuates Transcription due to Defective Release of Nuclear Receptor Corepressor from Chromatin
MH Liu, J Li, P Shen, B Husna, ES Tai, EL Yong |
Molecular Endocrinology | 2008 |
Aldose Reductase Regulates Hepatic Peroxisome Proliferator-activated Receptor α Phosphorylation and Activity to Impact Lipid Homeostasis
L Qiu, X Wu, JF Chau, IY Szeto, WY Tam, Z Guo, SK Chung, PJ Oates, SS Chung, JY Yang |
The Journal of biological chemistry | 2008 |
Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice
G Bryzgalova, L Lundholm, N Portwood, JÅ Gustafsson, A Khan, S Efendic, K Dahlman-Wright |
American journal of physiology. Endocrinology and metabolism | 2008 |
The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
JJ Lehman, S Boudina, NH Banke, N Sambandam, X Han, DM Young, TC Leone, RW Gross, ED Lewandowski, ED Abel, DP Kelly |
American journal of physiology. Heart and circulatory physiology | 2008 |
Sex Hormone Influence on Hepatitis in Young Male A/JCr Mice Infected with Helicobacter hepaticus
EJ Theve, Y Feng, K Taghizadeh, KS Cormier, DR Bell, JG Fox, AB Rogers |
Infection and immunity | 2008 |
PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
J Uthurralt, H Gordish-Dressman, M Bradbury, C Tesi-Rocha, J Devaney, B Harmon, EK Reeves, C Brandoli, BC Hansen, RL Seip, PD Thompson, TB Price, TJ Angelopoulos, PM Clarkson, NM Moyna, LS Pescatello, PS Visich, RF Zoeller, PM Gordon, EP Hoffman |
BMC Medical Genetics | 2007 |
Insulin-Resistant Heart Exhibits a Mitochondrial Biogenic Response Driven by the Peroxisome Proliferator-Activated Receptor- /PGC-1 Gene Regulatory Pathway
JG Duncan, JL Fong, DM Medeiros, BN Finck, DP Kelly |
Circulation | 2007 |
Genetic manipulations of PPARs: effects on obesity and metabolic disease
Y Barak, S Kim |
PPAR Research | 2007 |
Roles of PPARs on regulating myocardial energy and lipid homeostasis
Q Yang, Y Li |
Journal of Molecular Medicine | 2007 |
Sex differences in myocardial oxygen and glucose metabolism
LR Peterson, PF Soto, P Herrero, KB Schechtman, C Dence, RJ Gropler |
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology | 2007 |
Peroxisome proliferator–activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell–mediated autoimmunity
SE Dunn, SS Ousman, RA Sobel, L Zuniga, SE Baranzini, S Youssef, A Crowell, J Loh, J Oksenberg, L Steinman |
Journal of Experimental Medicine | 2007 |
A New Genetic Disorder in Mitochondrial Fatty Acid β-Oxidation: ACAD9 Deficiency
M He, SL Rutledge, DR Kelly, CA Palmer, G Murdoch, N Majumder, RD Nicholls, Z Pei, PA Watkins, J Vockley |
The American Journal of Human Genetics | 2007 |
Food entrainment of circadian gene expression altered in PPARalpha-/- brown fat and heart
BC Goh, X Wu, AE Evans, ML Johnson, MR Hill, JM Gimble |
Biochemical and Biophysical Research Communications | 2007 |
Estradiol Favors the Formation of Eicosapentaenoic Acid (20:5n-3) and n-3 Docosapentaenoic Acid (22:5n-3) from Alpha-Linolenic Acid (18:3n-3) in SH-SY5Y Neuroblastoma Cells
JM Alessandri, A Extier, B Langelier, MH Perruchot, C Heberden, P Guesnet, M Lavialle |
Lipids | 2007 |
Pharmacogenetics of thePPARgenes and cardiovascular disease
S Cresci |
Pharmacogenomics | 2007 |
Relationships between the functional PPARα Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people
T Sparsø, MS Hussain, G Andersen, I Hainerova, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen |
Molecular Genetics and Metabolism | 2007 |
Post-Genomic Cardiology
J Marín-García, MJ Goldenthal, GW Moe |
Post-Genomic Cardiology | 2007 |
Pharmacogenetics of the PPAR genes and cardiovascular disease
S Cresci |
Pharmacogenomics | 2007 |
Genome-wide analysis of PPARα activation in murine small intestine
M Bünger, HM van Bosch, J der Meijde, S Kersten, GJ Hooiveld, M Müller |
Physiological genomics | 2007 |
Role of oxidative stress in cardiac dysfunction of PPARα −/− mice
A Guellich, T Damy, Y Lecarpentier, M Conti, V Claes, JL Samuel, J Quillard, JL Hébert, T Pineau, C Coirault |
American journal of physiology. Heart and circulatory physiology | 2007 |
Mitochondria
SW Schaffer, MS Suleiman |
2007 | |
A Novel Peroxisome Proliferator-Activated Receptor Responsive Element-Luciferase Reporter Mouse Reveals Gender Specificity of Peroxisome Proliferator-Activated Receptor Activity in Liver
P Ciana, A Biserni, L Tatangelo, C Tiveron, AF Sciarroni, L Ottobrini, A Maggi |
Molecular Endocrinology | 2007 |
Cardiac PET and PET/CT Imaging
MF Carli, MJ Lipton |
2007 | |
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
Xueliang Du, Diane Edelstein, Silvana Obici, Ninon Higham, Ming-Hui Zou, and Michael Brownlee |
Journal of Clinical Investigation | 2006 |
Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia
E Sugiyama, N Tanaka, T Nakajima, Y Kamijo, S Yokoyama, Y Li, FJ Gonzalez, T Aoyama |
Biochemical and Biophysical Research Communications | 2006 |
Deranged energy substrate metabolism in the failing heart
Q Tian, PM Barger |
Current Hypertension Reports | 2006 |
Sorting out the roles of PPARα in energy metabolism and vascular homeostasis
P Lefebvre, G Chinetti, JC Fruchart, B Staels |
Journal of Clinical Investigation | 2006 |
Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies
JL Turgeon, MC Carr, PM Maki, ME Mendelsohn, PM Wise |
Endocrine reviews | 2006 |
Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice
AT de Souza, X Dai, AG Spencer, T Reppen, A Menzie, PL Roesch, Y He, MJ Caguyong, S Bloomer, H Herweijer, JA Wolff, JE Hagstrom, DL Lewis, PS Linsley, RG Ulrich |
Nucleic Acids Research | 2006 |
Therapeutic implications of the gender-specific aspects of cardiovascular disease
V Regitz-Zagrosek |
Nature Reviews Drug Discovery | 2006 |
The role of sex in cardiac function and diseaseThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum
MP Czubryt, L Espira, L Lamoureux, B Abrenica |
Canadian Journal of Physiology and Pharmacology | 2006 |
The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women
E Chan, CS Tan, M Deurenberg-Yap, KS Chia, SK Chew, ES Tai |
Atherosclerosis | 2006 |
Altered hepatic expression of SREBP-1 and PPARγ is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients
M Lemoine, V Barbu, PM Girard, M Kim, JP Bastard, D Wendum, F Paye, C Housset, J Capeau, L Serfaty |
AIDS | 2006 |
Sex dimorphism in cardiac pathophysiology: Experimental findings, hormonal mechanisms, and molecular mechanisms
XJ Du, L Fang, H Kiriazis |
Pharmacology & Therapeutics | 2006 |
Molecular Approaches to Study Control of Glucose Homeostasis
N Neubauer, RN Kulkarni |
ILAR journal / National Research Council, Institute of Laboratory Animal Resources | 2006 |
Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha
Cheol Whee Park, Hyeong Wook Kim, Seung Hyun Ko, Hyun Wha Chung, Sun Woo Lim, Chul Woo Yang, Yoon Sik Chang, Akira Sugawara, YouFei Guan, Matthew D Breyer |
Diabetes | 2006 |
Deletion of peroxisome proliferator-activated receptor-α induces an alteration of cardiac functions
C Loichot, L Jesel, A Tesse, A Tabernero, K Schoonjans, G Roul, I Carpusca, J Auwerx, R Andriantsitohaina |
American journal of physiology. Heart and circulatory physiology | 2006 |
Orphan nuclear receptors: therapeutic opportunities in skeletal muscle
AG Smith, GE Muscat |
American journal of physiology. Cell physiology | 2006 |
Pancreatic Islet Adaptation to Fasting Is Dependent on Peroxisome Proliferator-Activated Receptor α Transcriptional Up-Regulation of Fatty Acid Oxidation
S Gremlich, C Nolan, R Roduit, R Burcelin, ML Peyot, V Delghingaro-Augusto, B Desvergne, L Michalik, M Prentki, W Wahli |
Endocrinology | 2005 |
Regulation of adipocyte differentiation and function by polyunsaturated fatty acids
L Madsen, RK Petersen, K Kristiansen |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2005 |
Nutrition in Exercise & Sport
J Cooper, P Deuster |
Sports Nutrition | 2005 |
Skeletal muscle and nuclear hormone receptors: Implications for cardiovascular and metabolic disease
AG Smith, GE Muscat |
The International Journal of Biochemistry & Cell Biology | 2005 |
The PPAR genes, cardiovascular disease and the emergence of PPAR pharmacogenetics
S Cresci |
Expert Opinion on Pharmacotherapy | 2005 |
Biomarkers of Exposure and Reproduction-Related Effects in Mussels Exposed to Endocrine Disruptors
M Ortiz-Zarragoitia, MP Cajaraville |
Archives of Environmental Contamination and Toxicology | 2005 |
Modulation of peroxisome proliferator-activated receptors (PPARs) by PPARα- and PPARγ-specific ligands and by 17β-estradiol in isolated zebrafish hepatocytes
A Ibabe, A Herrero, MP Cajaraville |
Toxicology in Vitro | 2005 |
Effects of selected xenoestrogens on liver peroxisomes, vitellogenin levels and spermatogenic cell proliferation in male zebrafish
M Ortiz-Zarragoitia, MP Cajaraville |
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology | 2005 |
Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARα)
H Bihan, C Rouault, G Reach, V Poitout, B Staels, M Guerre-Millo |
FEBS Letters | 2005 |
Molecular regulation of lipotoxicity in the heart
Q Yang, L Cheng |
Drug Discovery Today: Disease Mechanisms | 2005 |
(+)- Z -Bisdehydrodoisynolic Acid Ameliorates Obesity and the Metabolic Syndrome in Female ZDF Rats
WJ Banz, J Davis, JJ Steinle, S Adler, J Oitker, TA Winters, DA Higginbotham, Y Hou, N Henry, R Peterson, CY Meyers |
Obesity research | 2005 |
Estrogen Regulation of Adiposity and Fuel Partitioning: EVIDENCE OF GENOMIC AND NON-GENOMIC REGULATION OF LIPOGENIC AND OXIDATIVE PATHWAYS
TM D'Eon, SC Souza, M Aronovitz, MS Obin, SK Fried, AS Greenberg |
The Journal of biological chemistry | 2005 |
High-unsaturated-fat, high-protein, and low-carbohydrate diet during pregnancy and lactation modulates hepatic lipid metabolism in female adult offspring
J Zhang, C Wang, PL Terroni, FR Cagampang, M Hanson, CD Byrne |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2005 |
Thyroid hormone interacts with PPARα and PGC-1 during mitochondrial maturation in sheep heart
TD McClure, ME Young, H Taegtmeyer, XH Ning, NE Buroker, J López-Guisa, MA Portman |
American journal of physiology. Heart and circulatory physiology | 2005 |
No effect of short-term testosterone manipulation on exercise substrate metabolism in men
B Braun, L Gerson, T Hagobian, D Grow, SR Chipkin |
Journal of applied physiology | 2005 |
Transgenic and Knockout Mice in Diabetes Research: Novel Insights into Pathophysiology, Limitations, and Perspectives
L Plum, FT Wunderlich, S Baudler, W Krone, JC Brüning |
Physiology (Bethesda, Md.) | 2005 |
Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring
KA Lillycrop, ES Phillips, AA Jackson, MA Hanson, GC Burdge |
The Journal of nutrition | 2005 |
Atherosclerosis: Diet and Drugs
A von Eckardstein |
2005 | |
Impaired fatty acid utilization in thioredoxin binding protein‐2 (TBP‐2)‐deficient mice: a unique animal model of Reye syndrome
S Oka, W Liu, H Masutani, H Hirata, Y Shinkai, S Yamada, T Yoshida, H Nakamura, J Yodoi |
The FASEB Journal | 2005 |
Impact of hormone replacement on myocardial fatty acid metabolism: Potential role of estrogen
P Herrero, P Soto, C Dence, Z Kisrievaware, D Delano, L Peterson, R Gropler |
Journal of Nuclear Cardiology | 2005 |
Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies
T Arimura, A Helbling-Leclerc, C Massart, S Varnous, F Niel, E Lacène, Y Fromes, M Toussaint, AM Mura, DI Keller, H Amthor, R Isnard, M Malissen, K Schwartz, G Bonne |
Human Molecular Genetics | 2004 |
Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats
K Fukumoto, A Pierro, VA Zammit, L Spitz, S Eaton |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2004 |
Antidiabetic actions of estrogen: Insight from human and genetic mouse models
JF Louet, C LeMay, F Mauvais-Jarvis |
Current Atherosclerosis Reports | 2004 |
Lipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation?
O Ziouzenkova, J Plutzky |
Current Opinion in Clinical Nutrition and Metabolic Care | 2004 |
Sexual dimorphism in lipid metabolic phenotype associated with old age in Sprague–Dawley rats
E Sanguino, R Bejarano, M Alegret, RM Sánchez, M Vázquez-Carrera, JC Laguna |
Experimental Gerontology | 2004 |
Effects of PPAR??, ?? and ?? haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study
S Chen, N Tsybouleva, CM Ballantyne, AM Gotto, AJ Marian |
Pharmacogenetics | 2004 |
Principles of Gender-Specific Medicine
G Supinski, LA Callahan |
Principles of Gender-Specific Medicine | 2004 |
Liver Fatty Acid-Binding Protein Colocalizes with Peroxisome Proliferator Activated Receptor α and Enhances Ligand Distribution to Nuclei of Living Cells †
H Huang, O Starodub, A McIntosh, BP Atshaves, G Woldegiorgis, AB Kier, F Schroeder |
Biochemistry | 2004 |
Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response
K Feingold, MS Kim, J Shigenaga, A Moser, C Grunfeld |
American journal of physiology. Endocrinology and metabolism | 2004 |
Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy
KD Stark, BJ Holub |
The American journal of clinical nutrition | 2004 |
Estrogen Modulates Developmentally Regulated Gene Expression in the Fetal Baboon Liver
MD Rosenthal, ED Albrecht, GJ Pepe |
Endocrine | 2004 |
Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle
C Nöhammer, F Brunner, G Wölkart, PB Staber, E Steyrer, FJ Gonzalez, R Zechner, G Hoefler |
Laboratory Investigation | 2003 |
Sex Hormones and Cardiomyopathic Phenotype Induced by Cardiac β2-Adrenergic Receptor Overexpression
XM Gao, A Agrotis, DJ Autelitano, E Percy, EA Woodcock, GL Jennings, AM Dart, XJ Du |
Endocrinology | 2003 |
Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5
MP Czubryt, J McAnally, GI Fishman, EN Olson |
Proceedings of the National Academy of Sciences | 2003 |
Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar−/−) mice
T Egawa, K Toda, Y Nemoto, M Ono, N Akisawa, T Saibara, Y Hayashi, M Hiroi, H Enzan, S Onishi |
Lipids | 2003 |
Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments
R Note, C Maisonneuve, P Lettéron, G Peytavin, F Djouadi, A Igoudjil, MC Guimont, M Biour, D Pessayre, B Fromenty |
Antimicrobial agents and chemotherapy | 2003 |
Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction
K Masamura, N Tanaka, M Yoshida, M Kato, Y Kawai, K Oida, I Miyamori |
Experimental and clinical cardiology | 2003 |
Skeletal muscle metabolism in physiology and in cancer disease
A Giordano, M Calvani, O Petillo, M Carteni', MR Melone, G Peluso |
Journal of Cellular Biochemistry | 2003 |
Peroxisome proliferator-activated receptor α is not the exclusive mediator of the effects of dietary cyclic FA in mice
L Bretillon, SE Alexson, F Joffre, B Pasquis, JL Sébédio |
Lipids | 2003 |
Nuclear Receptors
B Belandia, MG Parker |
Cell | 2003 |
Ovariectomy leads to increased insulin resistance in human apolipoprotein B transgenic mice lacking brown adipose tissue
Patty W Siri, Henry N Ginsberg |
Metabolism | 2003 |
Induction of the expression of the peroxisome proliferator-activated receptor alpha (PPARα) by clofibrate in jerboa tissues: Clofibrate Induces PPARα in Jerboa Tissues
S Amsaguine-Safir, A Bianchi, P Collet, C Huin-Schohn, A Jeanvoine, P Bécuwe, P Krémarik-Bouillaud, L Domenjoud, JM Keller, H Schohn, M Dauça |
Microscopy Research and Technique | 2003 |
PPAR-α effects on the heart and other vascular tissues
GA Francis, JS Annicotte, J Auwerx |
American journal of physiology. Heart and circulatory physiology | 2003 |
Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
MC Sugden, MJ Holness |
American journal of physiology. Endocrinology and metabolism | 2003 |
Bezafibrate is a dual ligand for PPARα and PPARβ: studies using null mice
JM Peters, T Aoyama, AM Burns, FJ Gonzalez |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2003 |
Myocardial Fatty Acid Metabolism: Independent Predictor of Left Ventricular Mass in Hypertensive Heart Disease
L de las Fuentes, P Herrero, LR Peterson, DP Kelly, RJ Gropler, VG Dávila-Román |
Hypertension | 2003 |
HCV/Oxidative Stress and Liver Disease
K Okita |
2003 | |
Mutation and biochemical analysis in carnitine palmitoyltransferase type II (CPT II) deficiency
SE Olpin, A Afifi, S Clark, NJ Manning, JR Bonham, A Dalton, JV Leonard, JM Land, BS Andresen, AA Morris, F Muntoni, D Turnbull, M Pourfarzam, S Rahman, RJ Pollitt |
Journal of Inherited Metabolic Disease | 2003 |
Sex Difference in Hepatic Peroxisome Proliferator-Activated Receptor α Expression: Influence of Pituitary and Gonadal Hormones
M Jalouli, L Carlsson, C Améen, D Lindén, A Ljungberg, L Michalik, S Edén, W Wahli, J Oscarsson |
Endocrinology | 2003 |
Cardiac-Specific Overexpression of PPAR alpha Leads to Metabolic and Functional Derangements Similar to the Diabetic Heart
Brian N. Finck, John J. Lehman, Teresa C. Leone, Michael J. Welch, Michael J. Bennett, Attila Kovacs, Xianlin Han, Richard W. Gross, Ray Kozak, Gary D. Lopaschuk, Daniel P. Kelly |
Journal of Clinical Investigation | 2002 |
Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells
DM Muoio, JM Way, CJ Tanner, DA Winegar, SA Kliewer, JA Houmard, WE Kraus, GL Dohm |
Diabetes | 2002 |
85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells
C Han, AJ Demetris, G Michalopoulos, JH Shelhamer, T Wu |
AJP Gastrointestinal and Liver Physiology | 2002 |
Regulatory Networks Controlling Mitochondrial Energy Production in the Developing, Hypertrophied, and Diabetic Heart
B Finck, J Lehman, P Barger, D Kelly |
Cold Spring Harbor Symposia on Quantitative Biology | 2002 |
Peroxisome proliferator-activated receptor agonists, hyperlipidaemia, and atherosclerosis
H Vosper, GA Khoudoli, TL Graham, CN Palmer |
Pharmacology & Therapeutics | 2002 |
Influence of gender and interleukin-10 deficiency on the inflammatory response during lung infection with Pseudomonas aeruginosa in mice
C Guilbault, P Stotland, C Lachance, M Tam, A Keller, L Thompson-Snipes, E Cowley, TA Hamilton, DH Eidelman, MM Stevenson, D Radzioch |
Immunology | 2002 |
Estrogen replacement stimulates fatty acid oxidation and impairs post-ischemic recovery of hearts from ovariectomized female rats
M Grist, RB Wambolt, GP Bondy, DR English, MF Allard |
Canadian Journal of Physiology and Pharmacology | 2002 |
Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth
JJ Lehman, DP Kelly |
Heart Failure Reviews | 2002 |
Peroxisome Proliferator-activated Receptor α (PPARα) Signaling in the Gene Regulatory Control of Energy Metabolism in the Normal and Diseased Heart
BN Finck, DP Kelly |
2002 | |
Estrogen Can Prevent or Reverse Obesity and Diabetes in Mice Expressing Human Islet Amyloid Polypeptide
JG Geisler, W Zawalich, K Zawalich, JR Lakey, H Stukenbrok, AJ Milici, WC Soeller |
Diabetes | 2002 |
Peroxisome Proliferator-Activated Receptor- Coactivator-1 Gene Locus: Associations With Obesity Indices in Middle-Aged Women
H Esterbauer, H Oberkofler, V Linnemayr, B Iglseder, M Hedegger, P Wolfsgruber, B Paulweber, G Fastner, F Krempler, W Patsch |
Diabetes | 2002 |
Has Angiogenesis Been Invited to the PPARty?
PM Barger |
Journal of Molecular and Cellular Cardiology | 2002 |
Liver Fatty Acid-binding Protein Targets Fatty Acids to the Nucleus: REAL TIME CONFOCAL AND MULTIPHOTON FLUORESCENCE IMAGING IN LIVING CELLS
H Huang, O Starodub, A McIntosh, AB Kier, F Schroeder |
The Journal of biological chemistry | 2002 |
Fatty Acid Homeostasis and Induction of Lipid Regulatory Genes in Skeletal Muscles of Peroxisome Proliferator-activated Receptor (PPAR) α Knock-out Mice: EVIDENCE FOR COMPENSATORY REGULATION BY PPARδ
DM Muoio, PS MacLean, DB Lang, S Li, JA Houmard, JM Way, DA Winegar, JC Corton, GL Dohm, WE Kraus |
The Journal of biological chemistry | 2002 |
Down-regulation of acyl-CoA oxidase gene expression and increased NF-κB activity in etomoxir-induced cardiac hypertrophy
À Cabrero, M Merlos, JC Laguna, MV Carrera |
Journal of lipid research | 2002 |
Gender difference in the leptin response to feeding in peroxisome-proliferator-activated receptor-alpha knockout mice
MS Lewitt, K Brismar |
International Journal of Obesity | 2002 |
Phenotypic variability among first-degree relatives with carnitine palmitoyltransferase II deficiency
GD Vladutiu, MJ Bennett, NM Fisher, D Smail, R Boriack, J Leddy, DR Pendergast |
Muscle & Nerve | 2002 |
Peroxisome Proliferator–Activated Receptor α Gene Regulates Left Ventricular Growth in Response to Exercise and Hypertension
Y Jamshidi, HE Montgomery, HW Hense, SG Myerson, IP Torra, B Staels, MJ World, A Doering, J Erdmann, C Hengstenberg, SE Humphries, H Schunkert, DM Flavell |
Circulation | 2002 |
Pleiotropic Actions of Peroxisome Proliferator–Activated Receptors in Lipid Metabolism and Atherosclerosis
O Barbier, IP Torra, Y Duguay, C Blanquart, JC Fruchart, C Glineur, B Staels |
Arteriosclerosis, thrombosis, and vascular biology | 2002 |
Peroxisome proliferator-activated receptor alpha deficiency reduces insulin resistance and atherosclerosis in apoE null mice
Karen Tordjman, Carlos Bernal-Mizrachi, Laura Zemany, Sherry Weng, Chu Feng, Fengjuan Zhang, Teresa C. Leone, Trey Coleman, Daniel P. Kelly, Clay F. Semenkovich |
Journal of Clinical Investigation | 2001 |
Effects of ovarian hormones on exercise metabolism
SE Campbell, MA Febbraio |
Current Opinion in Clinical Nutrition and Metabolic Care | 2001 |
Alternations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17β-estradiol or a peroxisome proliferator
K Toda, K Takeda, S Akira, T Saibara, T Okada, S Onishi, Y Shizuta |
The Journal of Steroid Biochemistry and Molecular Biology | 2001 |
Sex differences in carbohydrate metabolism
MA Tarnopolsky, BC Ruby |
Current Opinion in Clinical Nutrition and Metabolic Care | 2001 |
Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice
MS Lewitt, K Brismar, J Wang, IL Wivall-Helleryd, P Sindelar, FJ Gonzalez, T Bergman, GA Bobek |
Growth Hormone & IGF Research | 2001 |
Peroxisome Proliferator-Activated Receptors
A Elbrecht, A Adams, DE Moller |
2001 | |
PPAR- -Null Mice Are Protected From High-Fat Diet-Induced Insulin Resistance
M Guerre-Millo, C Rouault, P Poulain, J Andre, V Poitout, JM Peters, FJ Gonzalez, JC Fruchart, G Reach, B Staels |
Diabetes | 2001 |
Prolonged Inhibition of Muscle Carnitine Palmitoyltransferase-1 Promotes Intramyocellular Lipid Accumulation and Insulin Resistance in Rats
RL Dobbins, LS Szczepaniak, B Bentley, V Esser, J Myhill, JD McGarry |
Diabetes | 2001 |
Peroxisome Proliferator-activated Receptors in Atherosclerosis and Inflammation—An Update
CS Elangbam, RD Tyler, RM Lightfoot |
Toxicologic pathology | 2001 |
Antagonism of the Actions of Peroxisome Proliferator-activated Receptor-α by Bile Acids
CJ Sinal, M Yoon, FJ Gonzalez |
The Journal of biological chemistry | 2001 |
p38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α: A POTENTIAL ROLE IN THE CARDIAC METABOLIC STRESS RESPONSE
PM Barger, AC Browning, AN Garner, DP Kelly |
The Journal of biological chemistry | 2001 |
A Role for Peroxisome Proliferator-activated Receptor α (PPARα) in the Control of Cardiac Malonyl-CoA Levels: REDUCED FATTY ACID OXIDATION RATES AND INCREASED GLUCOSE OXIDATION RATES IN THE HEARTS OF MICE LACKING PPARα ARE ASSOCIATED WITH HIGHER CONCENTRATIONS OF MALONYL-CoA AND REDUCED EXPRESSION OF MALONYL-CoA DECARBOXYLASE
FM Campbell, R Kozak, A Wagner, JY Altarejos, JR Dyck, DD Belke, DL Severson, DP Kelly, GD Lopaschuk |
The Journal of biological chemistry | 2001 |
Peroxisome Proliferator-activated Receptor-γ Ligands Inhibit Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity
J Berger, M Tanen, A Elbrecht, A Hermanowski-Vosatka, DE Moller, SD Wright, R Thieringer |
The Journal of biological chemistry | 2001 |
Hypoxia Inhibits the Peroxisome Proliferator-activated Receptor α/ Retinoid X Receptor Gene Regulatory Pathway in Cardiac Myocytes: A MECHANISM FOR O 2 -DEPENDENT MODULATION OF MITOCHONDRIAL FATTY ACID OXIDATION
JM Huss, FH Levy, DP Kelly |
The Journal of biological chemistry | 2001 |
Peroxisome Proliferator-activated Receptor-α Regulates Lipid Homeostasis, but Is Not Associated with Obesity: STUDIES WITH CONGENIC MOUSE LINES
TE Akiyama, CJ Nicol, C Fievet, B Staels, JM Ward, J Auwerx, SS Lee, FJ Gonzalez, JM Peters |
The Journal of biological chemistry | 2001 |
Short-term 17β-estradiol decreases glucose R a but not whole body metabolism during endurance exercise
S Carter, S McKenzie, M Mourtzakis, DJ Mahoney, MA Tarnopolsky |
Journal of applied physiology | 2001 |
Substrate utilization during endurance exercise in men and women after endurance training
SL Carter, C Rennie, MA Tarnopolsky |
American journal of physiology. Endocrinology and metabolism | 2001 |
Peroxisome proliferator-activated receptor-α ligands inhibit cardiac lipoprotein lipase activity
R Carroll, DL Severson |
American journal of physiology. Heart and circulatory physiology | 2001 |
Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
SE Campbell, MA Febbraio |
American journal of physiology. Endocrinology and metabolism | 2001 |
Endocrine Regulation of Exercise Substrate Utilization in Women Compared to Men:
B Braun, T Horton |
Exercise and Sport Sciences Reviews | 2001 |
Myocardial Akt Activation and Gender: Increased Nuclear Activity in Females Versus Males
D Camper-Kirby, S Welch, A Walker, I Shiraishi, KD Setchell, E Schaefer, J Kajstura, P Anversa, MA Sussman |
Circulation research | 2001 |
PPARα deficiency increases secretion and serum levels of apolipoprotein B-containing lipoproteins
D Lindén, M Alsterholm, H Wennbo, J Oscarsson |
Journal of lipid research | 2001 |
Bezafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue
M Vázquez, N Roglans, A Cabrero, C Rodríguez, T Adzet, M Alegret, R M Sánchez, J C Laguna |
Molecular and Cellular Biochemistry | 2001 |
Deactivation of the peroxisome proliferation-activated receptor alpha during cardiac myocyte hypertrophic growth
Philip M. Barger, Jon M. Brandt, Teresa C. Leone, Carla J. Weinheimer, Daniel P. Kelly |
Journal of Clinical Investigation | 2000 |
Altered expression of fatty acid–metabolizing enzymes in aromatase-deficient mice
Y Nemoto, K Toda, M Ono, K Fujikawa-Adachi, T Saibara, S Onishi, H Enzan, T Okada, Y Shizuta |
Journal of Clinical Investigation | 2000 |
Regulation of Lipid and Lipoprotein Metabolism by PPAR Activators
P Gervois, IP Torra, JC Fruchart, B Staels |
Clinical Chemistry and Laboratory Medicine | 2000 |
Peroxisome proliferator-activated receptors: insight into multiple cellular functions
P Escher, W Wahli |
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2000 |
Frequency of stromal lineage colony forming units in bone marrow of peroxisome proliferator-activated receptor-α-null mice
X Wu, JM Peters, FJ Gonzalez, HS Prasad, MD Rohrer, JM Gimble |
Bone | 2000 |
Peroxisome proliferator-activated receptors in the cardiovascular system
D Bishop-Bailey |
British Journal of Pharmacology | 2000 |
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
RB Vega, JM Huss, DP Kelly |
Molecular and cellular biology | 2000 |
Less Extrahepatic Induction of Fatty Acid β-Oxidation Enzymes by PPARα
WS Cook, AV Yeldandi, MS Rao, T Hashimoto, JK Reddy |
Biochemical and Biophysical Research Communications | 2000 |
Genomics of the Human Carnitine Acyltransferase Genes
FR van der Leij, NC Huijkman, C Boomsma, JR Kuipers, B Bartelds |
Molecular Genetics and Metabolism | 2000 |
PPARα Agonists Reduce 11β-Hydroxysteroid Dehydrogenase Type 1 in the Liver
A Hermanowski-Vosatka, D Gerhold, SS Mundt, VA Loving, M Lu, Y Chen, A Elbrecht, M Wu, T Doebber, L Kelly, D Milot, Q Guo, PR Wang, M Ippolito, YS Chao, SD Wright, R Thieringer |
Biochemical and Biophysical Research Communications | 2000 |
The human peroxisome proliferator-activated receptor ?? gene: identification and functional characterization of two natural allelic variants
A Sapone, JM Peters, S Sakai, S Tomita, SS Papiha, R Dai, FK Friedman, FJ Gonzalez |
Pharmacogenetics | 2000 |
Regulation of Fatty Acid Transport Protein and Mitochondrial and Peroxisomal β-Oxidation Gene Expression by Fatty Acids in Developing Rats
F Ouali, F Djouadi, C Merlet-Bénichou, B Riveau, J Bastin |
Pediatric Research | 2000 |
Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes
À Cabrero, M Alegret, RM Sánchez, T Adzet, JC Laguna, M Vázquez |
FEBS Letters | 2000 |
Le rôle de ses activateurs dans la régulation de l'expression des gènes impliqués dans le métabolisme des lipoprotéines, l'inflammation vasculaire et l'athérosclérose
P Duriez, B Staels, JC Fruchart |
Annales de l'Institut Pasteur/Actualit�s | 2000 |
Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis
BP Neve, JC Fruchart, B Staels |
Biochemical Pharmacology | 2000 |
Etomoxir-induced PPARα-modulated enzymes protect during acute renal failure
D Portilla, G Dai, JM Peters, FJ Gonzalez, MD Crew, AD Proia |
American journal of physiology. Renal physiology | 2000 |
Molecular scanning of the human PPARα gene: association of the L162V mutation with hyperapobetalipoproteinemia
MC Vohl, P Lepage, D Gaudet, CG Brewer, C Bétard, P Perron, G Houde, C Cellier, JM Faith, JP Després, K Morgan, TJ Hudson |
Journal of lipid research | 2000 |
Regulation of the Liver Fatty Acid-binding Protein Gene by Hepatocyte Nuclear Factor 1α (HNF1α)
TE Akiyama, JM Ward, FJ Gonzalez |
The Journal of biological chemistry | 2000 |
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
S Kersten, J Seydoux, JM Peters, FJ Gonzalez, B Desvergne, W Wahli |
Journal of Clinical Investigation | 1999 |
Peroxisome proliterator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
JC Fruchart, P Duriez, B Staels |
Current Opinion in Lipidology | 1999 |
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
TC Leone, CJ Weinheimer, DP Kelly |
Proceedings of the National Academy of Sciences | 1999 |
Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions
L Michalik, W Wahli |
Current Opinion in Biotechnology | 1999 |
Etomoxir, Sodium 2-[6-(4-Chlorophenoxy)hexyl]oxirane-2-carboxylate, Up-Regulates Uncoupling Protein-3 mRNA Levels in Primary Culture of Rat Preadipocytes
À Cabrero, M Alegret, R Sánchez, T Adzet, JC Laguna, M Vázquez |
Biochemical and Biophysical Research Communications | 1999 |
Peroxisome proliferator-activated receptors: mediators of a fast food impact on gene regulation
L Gelman, J Auwerx |
Current Opinion in Clinical Nutrition and Metabolic Care | 1999 |
Inhibition of Adipogenesis by a COOH-Terminally Truncated Mutant of PPARγ2 in 3T3-L1 Cells
J Masugi, Y Tamori, M Kasuga |
Biochemical and Biophysical Research Communications | 1999 |
The role of the peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac lipid metabolism
F Djouadi, JM Brandt, CJ Weinheimer, TC Leone, FJ Gonzalez, DP Kelly |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1999 |
A critical role for the peroxisome proliferator-activated receptor (PPAR ) in the cellular fasting response: The PPAR -null mouse as a model of fatty acid oxidation disorders
TC Leone, CJ Weinheimer, DP Kelly |
Proceedings of the National Academy of Sciences | 1999 |
Peroxisome proliferator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging
SA Kliewer, SS Sundseth, SA Jones, PJ Brown, GB Wisely, CS Koble, P Devchand, W Wahli, TM Willson, JM Lenhard, JM Lehmann |
Current Opinion in Lipidology | 1999 |
Chromosomal, in silico and in vitro Expression Analysis of Cardiovascular-based Genes Encoding Zinc Finger Proteins
KS Dai, CC Liew |
Journal of Molecular and Cellular Cardiology | 1999 |
Evidence for a Novel Cardiac-enriched Retinoid X Receptor Partner
S Cresci, ML Clabby, DP Kelly |
The Journal of biological chemistry | 1999 |
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
B Desvergne, W Wahli |
Endocrine reviews | 1999 |
Orphan Nuclear Receptors: From Gene to Function*
V Giguère |
Endocrine reviews | 1999 |
Advances in Molecular and Cell Biology
KJ Clemetson |
Advances in Molecular and Cell Biology | 1997 |
Developmental and hormonal regulation of sarcomeric myosin heavy chain gene family
PM Barger, DP Kelly |
Circulation research | 1987 |