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Citations to this article

A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.
F Djouadi, … , F J Gonzalez, D P Kelly
F Djouadi, … , F J Gonzalez, D P Kelly
Published September 15, 1998
Citation Information: J Clin Invest. 1998;102(6):1083-1091. https://doi.org/10.1172/JCI3949.
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A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

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Abstract

The peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor implicated in the control of cellular lipid utilization. To test the hypothesis that PPARalpha is activated as a component of the cellular lipid homeostatic response, the expression of PPARalpha target genes was characterized in response to a perturbation in cellular lipid oxidative flux caused by pharmacologic inhibition of mitochondrial fatty acid import. Inhibition of fatty acid oxidative flux caused a feedback induction of PPARalpha target genes encoding fatty acid oxidation enzymes in liver and heart. In mice lacking PPARalpha (PPARalpha-/-), inhibition of cellular fatty acid flux caused massive hepatic and cardiac lipid accumulation, hypoglycemia, and death in 100% of male, but only 25% of female PPARalpha-/- mice. The metabolic phenotype of male PPARalpha-/- mice was rescued by a 2-wk pretreatment with beta-estradiol. These results demonstrate a pivotal role for PPARalpha in lipid and glucose homeostasis in vivo and implicate estrogen signaling pathways in the regulation of cardiac and hepatic lipid metabolism.

Authors

F Djouadi, C J Weinheimer, J E Saffitz, C Pitchford, J Bastin, F J Gonzalez, D P Kelly

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PPAR Research 2011
DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle[S]
L Liu, S Yu, RS Khan, GP Ables, KG Bharadwaj, Y Hu, LA Huggins, JW Eriksson, LK Buckett, AV Turnbull, HN Ginsberg, WS Blaner, LS Huang, IJ Goldberg
Journal of lipid research 2011
FENOFIBRATE ADMINISTRATION DOES NOT AFFECT MUSCLE TRIGLYCERIDE CONCENTRATION OR INSULIN SENSITIVITY IN HUMANS
L Perreault, BC Bergman, DM Hunerdosse, DJ Howard, RH Eckel
Metabolism: clinical and experimental 2011
ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor α Expression in Pancreatic β-Cells*
M Boergesen, LC Poulsen, SF Schmidt, F Frigerio, P Maechler, S Mandrup
The Journal of biological chemistry 2011
Sexual dimorphism in cardiac triacylglyceride dynamics in mice on long term caloric restriction
NH Banke, L Yan, KM Pound, S Dhar, H Reinhardt, MS de Lorenzo, SF Vatner, ED Lewandowski
Journal of Molecular and Cellular Cardiology 2011
Progress in Molecular Biology and Translational Science
JF Wilkins, F Úbeda
Modifications of Nuclear DNA and its Regulatory Proteins 2011
Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia
AK El-Ansary, AG Bacha, LY Al-Ayahdi
Lipids in Health and Disease 2011
New insights into the role of PPARs
A Montagner, G Rando, G Degueurce, N Leuenberger, L Michalik, W Wahli
Prostaglandins, Leukotrienes and Essential Fatty Acids 2011
Sex differences in nuclear receptor-regulated liver metabolic pathways
G Rando, W Wahli
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2011
Sex and gender differences in myocardial hypertrophy and heart failure
V Regitz-Zagrosek, U Seeland
Wiener Medizinische Wochenschrift 2011
Disruption of CD38 gene enhances cardiac functions by elevating serum testosterone in the male null mice
L Gan, W Jiang, YF Xiao, L Deng, LD Gu, ZY Guo, ZC Zhou, D Wu, HB Xin
Life Sciences 2011
Red Clover Extract Ameliorates Dyslipidemia in Streptozotocin-induced Diabetic C57BL/6 Mice by Activating Hepatic PPARα : RED CLOVER EXTRACT AND DIABETIC DYSLIPIDEMIA
L Qiu, H Ye, L Chen, Y Hong, F Zhong, T Zhang
Phytotherapy Research 2011
Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-α and Ameliorates Hepatosteatosis in Diabetic db/db Mice
L Qiu, J Lin, F Xu, Y Gao, C Zhang, Y Liu, Y Luo, JY Yang
Experimental Diabetes Research 2011
DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle
L Liu, S Yu, RS Khan, GP Ables, KG Bharadwaj, Y Hu, LA Huggins, JW Eriksson, LK Buckett, AV Turnbull, HN Ginsberg, WS Blaner, LS Huang, IJ Goldberg
Journal of lipid research 2011
ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor α Expression in Pancreatic β-Cells
M Boergesen, LC Poulsen, SF Schmidt, F Frigerio, P Maechler, S Mandrup
The Journal of biological chemistry 2011
Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart
P Wang, J Liu, Y Li, S Wu, J Luo, H Yang, R Subbiah, J Chatham, O Zhelyabovska, Q Yang
Circulation research 2010
What we know and do not know about sex and cardiac disease
JP Konhilas
Journal of biomedicine & biotechnology 2010
A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes
S Cresci, JM Huss, AL Beitelshees, PG Jones, MR Minton, GW Dorn, DP Kelly, JA Spertus, HL McLeod
PloS one 2010
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways
Y Lecarpentier, V Claes, JL Hébert
PPAR Research 2010
Sex-different hepatic glycogen content and glucose output in rats
C Gustavsson, K Yassin, E Wahlström, L Cheung, J Lindberg, K Brismar, CG Östenson, G Norstedt, P Tollet-Egnell
BMC Biochemistry 2010
A Maternal “Junk Food” Diet in Pregnancy and Lactation Promotes Nonalcoholic Fatty Liver Disease in Rat Offspring
SA Bayol, BH Simbi, RC Fowkes, NC Stickland
Endocrinology 2010
Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity
D Zadravec, A Brolinson, RM Fisher, C Carneheim, RI Csikasz, J Bertrand-Michel, J Borén, H Guillou, M Rudling, A Jacobsson
The FASEB Journal 2010
Conditional PPARγ knockout from cardiomyocytes of adult mice impairs myocardial fatty acid utilization and cardiac function
J Luo, S Wu, J Liu, Y Li, H Yang, T Kim, O Zhelyabovska, G Ding, Y Zhou, Y Yang, Q Yang
American journal of translational research 2010
Fulminant hepatic failure requiring liver transplantation in 22q13.3 deletion syndrome
O Bartsch, E Schneider, N Damatova, R Weis, M Tufano, R Iorio, A Ahmed, V Beyer, U Zechner, T Haaf
American Journal of Medical Genetics Part A 2010
Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride
P Chen, X Kakan, J Zhang
FEBS Letters 2010
A PPARα Promoter Variant Impairs ERR-Dependent Transactivation and Decreases Mortality after Acute Coronary Ischemia in Patients with Diabetes
S Cresci, JM Huss, AL Beitelshees, PG Jones, MR Minton, GW Dorn, DP Kelly, JA Spertus, HL McLeod, A Leri
PloS one 2010
Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERα-deficient mice
V Ribas, MT Nguyen, DC Henstridge, AK Nguyen, SW Beaven, MJ Watt, AL Hevener
American journal of physiology. Endocrinology and metabolism 2010
CYP2J2 expression activates PPARalpha in vitro and in vivo
David Bishop-Bailey, Mary C. Sugden, Darryl C. Zeldin, Jessica A. Wray, Gemma K. Greenwood, Salma Samsuddin, Laura M. Degraff, J. Alyce Bradbury, Derek W. Gilroy, Mark J. Holness, Timothy D. Warner
PloS one 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
PPARs and the Cardiovascular System
M Hamblin, L Chang, Y Fan, J Zhang, YE Chen
Antioxidants & Redox Signaling 2009
Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice
V Ribas, MT Nguyen, DC Henstridge, AK Nguyen, SW Beaven, MJ Watt, AL Hevener
American journal of physiology. Endocrinology and metabolism 2009
A potential link between peroxisome proliferator-activated receptor signalling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy
F Djouadi, Y Lecarpentier, JL Hebert, P Charron, J Bastin, C Coirault
Cardiovascular Research 2009
Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm
KR Feingold, A Moser, SM Patzek, JK Shigenaga, C Grunfeld
Journal of lipid research 2009
Hepatic phenotype of liver fatty acid binding protein gene-ablated mice
GG Martin, BP Atshaves, H Huang, AL McIntosh, BJ Williams, PJ Pai, DH Russell, AB Kier, F Schroeder
American journal of physiology. Gastrointestinal and liver physiology 2009
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A
LC Enns, JF Morton, RS Mangalindan, GS McKnight, MW Schwartz, MR Kaeberlein, BK Kennedy, PS Rabinovitch, WC Ladiges
The journals of gerontology. Series A, Biological sciences and medical sciences 2009
Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults
EM Urbina, P Khoury, LJ Martin, D D'Alessio, LM Dolan
International Journal of Obesity 2009
Sex differences in global mRNA content of human skeletal muscle
AC Maher, MH Fu, RJ Isfort, AR Varbanov, XA Qu, MA Tarnopolsky
PloS one 2009
Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse
HJ Atherton, MK Gulston, NJ Bailey, KK Cheng, W Zhang, K Clarke, JL Griffin
Molecular Systems Biology 2009
Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock
X Yang, YK Zhang, N Esterly, CD Klaassen, YJ Wan
Journal of Biochemistry 2009
High Dietary Fat Exacerbates Weight Gain and Obesity in Female Liver Fatty Acid Binding Protein Gene-Ablated Mice
BP Atshaves, AL McIntosh, SM Storey, KK Landrock, AB Kier, F Schroeder
Lipids 2009
Hepatic lipid metabolism response to dietary fatty acids is differently modulated by PPARα in male and female mice
A Morise, C Thomas, JF Landrier, P Besnard, D Hermier
European Journal of Nutrition 2009
Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease
E Robinson, DJ Grieve
Pharmacology & Therapeutics 2009
Sex-Based Cardiac Physiology
ED Luczak, LA Leinwand
Annual Review of Physiology 2009
Novel plasma phospholipid biomarkers of autism: Mitochondrial dysfunction as a putative causative mechanism
É Pastural, S Ritchie, Y Lu, W Jin, A Kavianpour, KK Su-Myat, D Heath, PL Wood, M Fisk, DB Goodenowe
Prostaglandins, Leukotrienes and Essential Fatty Acids 2009
The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPARα In Vitro and In Vivo
JA Wray, MC Sugden, DC Zeldin, GK Greenwood, S Samsuddin, L Miller-Degraff, JA Bradbury, MJ Holness, TD Warner, D Bishop-Bailey, D Tomé
PloS one 2009
Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm
KR Feingold, A Moser, SM Patzek, JK Shigenaga, C Grunfeld
Journal of lipid research 2009
Hepatic phenotype of liver fatty acid binding protein gene-ablated mice
GG Martin, BP Atshaves, H Huang, AL McIntosh, BJ Williams, PJ Pai, DH Russell, AB Kier, F Schroeder
AJP Gastrointestinal and Liver Physiology 2009
Recent Developments in Liver Pathology
BC Yan, JA Hart
Archives of pathology & laboratory medicine 2009
Sex-specific pathways in early cardiac response to pressure overload in mice
H Witt, C Schubert, J Jaekel, D Fliegner, A Penkalla, K Tiemann, J Stypmann, S Roepcke, S Brokat, S Mahmoodzadeh, E Brozova, MM Davidson, PR Noppinger, C Grohé, V Regitz-Zagrosek
Journal of Molecular Medicine 2008
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
JJ Lehman, S Boudina, NH Banke, N Sambandam, X Han, DM Young, TC Leone, RW Gross, ED Lewandowski, ED Abel, DP Kelly
American journal of physiology. Heart and circulatory physiology 2008
[The binuclear iron site of the membrane-bound methane hydroxylase from Methylococcus capsulatus (strain M)]
PG Isaacson, MQ Du
Bioorganicheskaia khimiia 2008
PPARs as therapeutic targets for correction of inborn mitochondrial fatty acid oxidation disorders
F Djouadi, J Bastin
Journal of Inherited Metabolic Disease 2008
Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice
G Bryzgalova, L Lundholm, N Portwood, JA Gustafsson, A Khan, S Efendic, K Dahlman-Wright
American journal of physiology. Endocrinology and metabolism 2008
Peroxisome proliferator-activated receptor-alpha modulates insulin gene transcription factors and inflammation in adipose tissues in mice
A Yessoufou, JM Atègbo, E Attakpa, A Hichami, K Moutairou, KL Dramane, NA Khan
Molecular and Cellular Biochemistry 2008
PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease
S Cresci
PPAR Research 2008
Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation
A Akki, K Smith, AM Seymour
Molecular and Cellular Biochemistry 2008
Sex differences in the control of glucose homeostasis
E Blaak
Current Opinion in Clinical Nutrition and Metabolic Care 2008
Chronic palmitate exposure inhibits AMPKα and decreases glucose-stimulated insulin secretion from β-cells: modulation by fenofibrate
Y SUN, M REN, G GAO, B GONG, W XIN, H GUO, X ZHANG, L GAO, J ZHAO
Acta Pharmacologica Sinica 2008
Enhanced detection of genetic association of hypertensive heart disease by analysis of latent phenotypes
CC Gu, HR Flores, L las Fuentes, VG Dávila-Román
Genetic Epidemiology 2008
Muscle Physiology in Healthy Men and Women and Those with Metabolic Myopathies
MC Devries, MA Tarnopolsky
Neurologic Clinics 2008
The PPAR trio: Regulators of myocardial energy metabolism in health and disease
JA Madrazo, DP Kelly
Journal of Molecular and Cellular Cardiology 2008
Modulación del PPARα por agentes farmacológicos y naturales y sus implicaciones metabólicas
MI Panadero, MC González, E Herrera, C Bocos
Clínica e Investigación en Arteriosclerosis 2008
[The binuclear iron site of the membrane-bound methane hydroxylase from Methylococcus capsulatus (strain M)]
PG Isaacson, MQ Du
Bioorganicheskaia khimiia 2008
A Natural Polymorphism in Peroxisome Proliferator-Activated Receptor-α Hinge Region Attenuates Transcription due to Defective Release of Nuclear Receptor Corepressor from Chromatin
MH Liu, J Li, P Shen, B Husna, ES Tai, EL Yong
Molecular Endocrinology 2008
Aldose Reductase Regulates Hepatic Peroxisome Proliferator-activated Receptor α Phosphorylation and Activity to Impact Lipid Homeostasis
L Qiu, X Wu, JF Chau, IY Szeto, WY Tam, Z Guo, SK Chung, PJ Oates, SS Chung, JY Yang
The Journal of biological chemistry 2008
Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice
G Bryzgalova, L Lundholm, N Portwood, JÅ Gustafsson, A Khan, S Efendic, K Dahlman-Wright
American journal of physiology. Endocrinology and metabolism 2008
The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
JJ Lehman, S Boudina, NH Banke, N Sambandam, X Han, DM Young, TC Leone, RW Gross, ED Lewandowski, ED Abel, DP Kelly
American journal of physiology. Heart and circulatory physiology 2008
Sex Hormone Influence on Hepatitis in Young Male A/JCr Mice Infected with Helicobacter hepaticus
EJ Theve, Y Feng, K Taghizadeh, KS Cormier, DR Bell, JG Fox, AB Rogers
Infection and immunity 2008
PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
J Uthurralt, H Gordish-Dressman, M Bradbury, C Tesi-Rocha, J Devaney, B Harmon, EK Reeves, C Brandoli, BC Hansen, RL Seip, PD Thompson, TB Price, TJ Angelopoulos, PM Clarkson, NM Moyna, LS Pescatello, PS Visich, RF Zoeller, PM Gordon, EP Hoffman
BMC Medical Genetics 2007
Insulin-Resistant Heart Exhibits a Mitochondrial Biogenic Response Driven by the Peroxisome Proliferator-Activated Receptor- /PGC-1  Gene Regulatory Pathway
JG Duncan, JL Fong, DM Medeiros, BN Finck, DP Kelly
Circulation 2007
Genetic manipulations of PPARs: effects on obesity and metabolic disease
Y Barak, S Kim
PPAR Research 2007
Roles of PPARs on regulating myocardial energy and lipid homeostasis
Q Yang, Y Li
Journal of Molecular Medicine 2007
Sex differences in myocardial oxygen and glucose metabolism
LR Peterson, PF Soto, P Herrero, KB Schechtman, C Dence, RJ Gropler
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007
Peroxisome proliferator–activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell–mediated autoimmunity
SE Dunn, SS Ousman, RA Sobel, L Zuniga, SE Baranzini, S Youssef, A Crowell, J Loh, J Oksenberg, L Steinman
Journal of Experimental Medicine 2007
A New Genetic Disorder in Mitochondrial Fatty Acid β-Oxidation: ACAD9 Deficiency
M He, SL Rutledge, DR Kelly, CA Palmer, G Murdoch, N Majumder, RD Nicholls, Z Pei, PA Watkins, J Vockley
The American Journal of Human Genetics 2007
Food entrainment of circadian gene expression altered in PPARalpha-/- brown fat and heart
BC Goh, X Wu, AE Evans, ML Johnson, MR Hill, JM Gimble
Biochemical and Biophysical Research Communications 2007
Estradiol Favors the Formation of Eicosapentaenoic Acid (20:5n-3) and n-3 Docosapentaenoic Acid (22:5n-3) from Alpha-Linolenic Acid (18:3n-3) in SH-SY5Y Neuroblastoma Cells
JM Alessandri, A Extier, B Langelier, MH Perruchot, C Heberden, P Guesnet, M Lavialle
Lipids 2007
Pharmacogenetics of thePPARgenes and cardiovascular disease
S Cresci
Pharmacogenomics 2007
Relationships between the functional PPARα Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people
T Sparsø, MS Hussain, G Andersen, I Hainerova, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen
Molecular Genetics and Metabolism 2007
Post-Genomic Cardiology
J Marín-García, MJ Goldenthal, GW Moe
Post-Genomic Cardiology 2007
Pharmacogenetics of the PPAR genes and cardiovascular disease
S Cresci
Pharmacogenomics 2007
Genome-wide analysis of PPARα activation in murine small intestine
M Bünger, HM van Bosch, J der Meijde, S Kersten, GJ Hooiveld, M Müller
Physiological genomics 2007
Role of oxidative stress in cardiac dysfunction of PPARα −/− mice
A Guellich, T Damy, Y Lecarpentier, M Conti, V Claes, JL Samuel, J Quillard, JL Hébert, T Pineau, C Coirault
American journal of physiology. Heart and circulatory physiology 2007
Mitochondria
SW Schaffer, MS Suleiman
2007
A Novel Peroxisome Proliferator-Activated Receptor Responsive Element-Luciferase Reporter Mouse Reveals Gender Specificity of Peroxisome Proliferator-Activated Receptor Activity in Liver
P Ciana, A Biserni, L Tatangelo, C Tiveron, AF Sciarroni, L Ottobrini, A Maggi
Molecular Endocrinology 2007
Cardiac PET and PET/CT Imaging
MF Carli, MJ Lipton
2007
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
Xueliang Du, Diane Edelstein, Silvana Obici, Ninon Higham, Ming-Hui Zou, and Michael Brownlee
Journal of Clinical Investigation 2006
Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia
E Sugiyama, N Tanaka, T Nakajima, Y Kamijo, S Yokoyama, Y Li, FJ Gonzalez, T Aoyama
Biochemical and Biophysical Research Communications 2006
Deranged energy substrate metabolism in the failing heart
Q Tian, PM Barger
Current Hypertension Reports 2006
Sorting out the roles of PPARα in energy metabolism and vascular homeostasis
P Lefebvre, G Chinetti, JC Fruchart, B Staels
Journal of Clinical Investigation 2006
Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies
JL Turgeon, MC Carr, PM Maki, ME Mendelsohn, PM Wise
Endocrine reviews 2006
Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice
AT de Souza, X Dai, AG Spencer, T Reppen, A Menzie, PL Roesch, Y He, MJ Caguyong, S Bloomer, H Herweijer, JA Wolff, JE Hagstrom, DL Lewis, PS Linsley, RG Ulrich
Nucleic Acids Research 2006
Therapeutic implications of the gender-specific aspects of cardiovascular disease
V Regitz-Zagrosek
Nature Reviews Drug Discovery 2006
The role of sex in cardiac function and diseaseThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum
MP Czubryt, L Espira, L Lamoureux, B Abrenica
Canadian Journal of Physiology and Pharmacology 2006
The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women
E Chan, CS Tan, M Deurenberg-Yap, KS Chia, SK Chew, ES Tai
Atherosclerosis 2006
Altered hepatic expression of SREBP-1 and PPARγ is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients
M Lemoine, V Barbu, PM Girard, M Kim, JP Bastard, D Wendum, F Paye, C Housset, J Capeau, L Serfaty
AIDS 2006
Sex dimorphism in cardiac pathophysiology: Experimental findings, hormonal mechanisms, and molecular mechanisms
XJ Du, L Fang, H Kiriazis
Pharmacology & Therapeutics 2006
Molecular Approaches to Study Control of Glucose Homeostasis
N Neubauer, RN Kulkarni
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2006
Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha
Cheol Whee Park, Hyeong Wook Kim, Seung Hyun Ko, Hyun Wha Chung, Sun Woo Lim, Chul Woo Yang, Yoon Sik Chang, Akira Sugawara, YouFei Guan, Matthew D Breyer
Diabetes 2006
Deletion of peroxisome proliferator-activated receptor-α induces an alteration of cardiac functions
C Loichot, L Jesel, A Tesse, A Tabernero, K Schoonjans, G Roul, I Carpusca, J Auwerx, R Andriantsitohaina
American journal of physiology. Heart and circulatory physiology 2006
Orphan nuclear receptors: therapeutic opportunities in skeletal muscle
AG Smith, GE Muscat
American journal of physiology. Cell physiology 2006
Pancreatic Islet Adaptation to Fasting Is Dependent on Peroxisome Proliferator-Activated Receptor α Transcriptional Up-Regulation of Fatty Acid Oxidation
S Gremlich, C Nolan, R Roduit, R Burcelin, ML Peyot, V Delghingaro-Augusto, B Desvergne, L Michalik, M Prentki, W Wahli
Endocrinology 2005
Regulation of adipocyte differentiation and function by polyunsaturated fatty acids
L Madsen, RK Petersen, K Kristiansen
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2005
Nutrition in Exercise & Sport
J Cooper, P Deuster
Sports Nutrition 2005
Skeletal muscle and nuclear hormone receptors: Implications for cardiovascular and metabolic disease
AG Smith, GE Muscat
The International Journal of Biochemistry & Cell Biology 2005
The PPAR genes, cardiovascular disease and the emergence of PPAR pharmacogenetics
S Cresci
Expert Opinion on Pharmacotherapy 2005
Biomarkers of Exposure and Reproduction-Related Effects in Mussels Exposed to Endocrine Disruptors
M Ortiz-Zarragoitia, MP Cajaraville
Archives of Environmental Contamination and Toxicology 2005
Modulation of peroxisome proliferator-activated receptors (PPARs) by PPARα- and PPARγ-specific ligands and by 17β-estradiol in isolated zebrafish hepatocytes
A Ibabe, A Herrero, MP Cajaraville
Toxicology in Vitro 2005
Effects of selected xenoestrogens on liver peroxisomes, vitellogenin levels and spermatogenic cell proliferation in male zebrafish
M Ortiz-Zarragoitia, MP Cajaraville
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2005
Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARα)
H Bihan, C Rouault, G Reach, V Poitout, B Staels, M Guerre-Millo
FEBS Letters 2005
Molecular regulation of lipotoxicity in the heart
Q Yang, L Cheng
Drug Discovery Today: Disease Mechanisms 2005
(+)- Z -Bisdehydrodoisynolic Acid Ameliorates Obesity and the Metabolic Syndrome in Female ZDF Rats
WJ Banz, J Davis, JJ Steinle, S Adler, J Oitker, TA Winters, DA Higginbotham, Y Hou, N Henry, R Peterson, CY Meyers
Obesity research 2005
Estrogen Regulation of Adiposity and Fuel Partitioning: EVIDENCE OF GENOMIC AND NON-GENOMIC REGULATION OF LIPOGENIC AND OXIDATIVE PATHWAYS
TM D'Eon, SC Souza, M Aronovitz, MS Obin, SK Fried, AS Greenberg
The Journal of biological chemistry 2005
High-unsaturated-fat, high-protein, and low-carbohydrate diet during pregnancy and lactation modulates hepatic lipid metabolism in female adult offspring
J Zhang, C Wang, PL Terroni, FR Cagampang, M Hanson, CD Byrne
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2005
Thyroid hormone interacts with PPARα and PGC-1 during mitochondrial maturation in sheep heart
TD McClure, ME Young, H Taegtmeyer, XH Ning, NE Buroker, J López-Guisa, MA Portman
American journal of physiology. Heart and circulatory physiology 2005
No effect of short-term testosterone manipulation on exercise substrate metabolism in men
B Braun, L Gerson, T Hagobian, D Grow, SR Chipkin
Journal of applied physiology 2005
Transgenic and Knockout Mice in Diabetes Research: Novel Insights into Pathophysiology, Limitations, and Perspectives
L Plum, FT Wunderlich, S Baudler, W Krone, JC Brüning
Physiology (Bethesda, Md.) 2005
Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring
KA Lillycrop, ES Phillips, AA Jackson, MA Hanson, GC Burdge
The Journal of nutrition 2005
Atherosclerosis: Diet and Drugs
A von Eckardstein
2005
Impaired fatty acid utilization in thioredoxin binding protein‐2 (TBP‐2)‐deficient mice: a unique animal model of Reye syndrome
S Oka, W Liu, H Masutani, H Hirata, Y Shinkai, S Yamada, T Yoshida, H Nakamura, J Yodoi
The FASEB Journal 2005
Impact of hormone replacement on myocardial fatty acid metabolism: Potential role of estrogen
P Herrero, P Soto, C Dence, Z Kisrievaware, D Delano, L Peterson, R Gropler
Journal of Nuclear Cardiology 2005
Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies
T Arimura, A Helbling-Leclerc, C Massart, S Varnous, F Niel, E Lacène, Y Fromes, M Toussaint, AM Mura, DI Keller, H Amthor, R Isnard, M Malissen, K Schwartz, G Bonne
Human Molecular Genetics 2004
Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats
K Fukumoto, A Pierro, VA Zammit, L Spitz, S Eaton
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2004
Antidiabetic actions of estrogen: Insight from human and genetic mouse models
JF Louet, C LeMay, F Mauvais-Jarvis
Current Atherosclerosis Reports 2004
Lipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation?
O Ziouzenkova, J Plutzky
Current Opinion in Clinical Nutrition and Metabolic Care 2004
Sexual dimorphism in lipid metabolic phenotype associated with old age in Sprague–Dawley rats
E Sanguino, R Bejarano, M Alegret, RM Sánchez, M Vázquez-Carrera, JC Laguna
Experimental Gerontology 2004
Effects of PPAR??, ?? and ?? haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study
S Chen, N Tsybouleva, CM Ballantyne, AM Gotto, AJ Marian
Pharmacogenetics 2004
Principles of Gender-Specific Medicine
G Supinski, LA Callahan
Principles of Gender-Specific Medicine 2004
Liver Fatty Acid-Binding Protein Colocalizes with Peroxisome Proliferator Activated Receptor α and Enhances Ligand Distribution to Nuclei of Living Cells †
H Huang, O Starodub, A McIntosh, BP Atshaves, G Woldegiorgis, AB Kier, F Schroeder
Biochemistry 2004
Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response
K Feingold, MS Kim, J Shigenaga, A Moser, C Grunfeld
American journal of physiology. Endocrinology and metabolism 2004
Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy
KD Stark, BJ Holub
The American journal of clinical nutrition 2004
Estrogen Modulates Developmentally Regulated Gene Expression in the Fetal Baboon Liver
MD Rosenthal, ED Albrecht, GJ Pepe
Endocrine 2004
Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle
C Nöhammer, F Brunner, G Wölkart, PB Staber, E Steyrer, FJ Gonzalez, R Zechner, G Hoefler
Laboratory Investigation 2003
Sex Hormones and Cardiomyopathic Phenotype Induced by Cardiac β2-Adrenergic Receptor Overexpression
XM Gao, A Agrotis, DJ Autelitano, E Percy, EA Woodcock, GL Jennings, AM Dart, XJ Du
Endocrinology 2003
Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5
MP Czubryt, J McAnally, GI Fishman, EN Olson
Proceedings of the National Academy of Sciences 2003
Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar−/−) mice
T Egawa, K Toda, Y Nemoto, M Ono, N Akisawa, T Saibara, Y Hayashi, M Hiroi, H Enzan, S Onishi
Lipids 2003
Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments
R Note, C Maisonneuve, P Lettéron, G Peytavin, F Djouadi, A Igoudjil, MC Guimont, M Biour, D Pessayre, B Fromenty
Antimicrobial agents and chemotherapy 2003
Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction
K Masamura, N Tanaka, M Yoshida, M Kato, Y Kawai, K Oida, I Miyamori
Experimental and clinical cardiology 2003
Skeletal muscle metabolism in physiology and in cancer disease
A Giordano, M Calvani, O Petillo, M Carteni', MR Melone, G Peluso
Journal of Cellular Biochemistry 2003
Peroxisome proliferator-activated receptor α is not the exclusive mediator of the effects of dietary cyclic FA in mice
L Bretillon, SE Alexson, F Joffre, B Pasquis, JL Sébédio
Lipids 2003
Nuclear Receptors
B Belandia, MG Parker
Cell 2003
Ovariectomy leads to increased insulin resistance in human apolipoprotein B transgenic mice lacking brown adipose tissue
Patty W Siri, Henry N Ginsberg
Metabolism 2003
Induction of the expression of the peroxisome proliferator-activated receptor alpha (PPARα) by clofibrate in jerboa tissues: Clofibrate Induces PPARα in Jerboa Tissues
S Amsaguine-Safir, A Bianchi, P Collet, C Huin-Schohn, A Jeanvoine, P Bécuwe, P Krémarik-Bouillaud, L Domenjoud, JM Keller, H Schohn, M Dauça
Microscopy Research and Technique 2003
PPAR-α effects on the heart and other vascular tissues
GA Francis, JS Annicotte, J Auwerx
American journal of physiology. Heart and circulatory physiology 2003
Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
MC Sugden, MJ Holness
American journal of physiology. Endocrinology and metabolism 2003
Bezafibrate is a dual ligand for PPARα and PPARβ: studies using null mice
JM Peters, T Aoyama, AM Burns, FJ Gonzalez
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2003
Myocardial Fatty Acid Metabolism: Independent Predictor of Left Ventricular Mass in Hypertensive Heart Disease
L de las Fuentes, P Herrero, LR Peterson, DP Kelly, RJ Gropler, VG Dávila-Román
Hypertension 2003
HCV/Oxidative Stress and Liver Disease
K Okita
2003
Mutation and biochemical analysis in carnitine palmitoyltransferase type II (CPT II) deficiency
SE Olpin, A Afifi, S Clark, NJ Manning, JR Bonham, A Dalton, JV Leonard, JM Land, BS Andresen, AA Morris, F Muntoni, D Turnbull, M Pourfarzam, S Rahman, RJ Pollitt
Journal of Inherited Metabolic Disease 2003
Sex Difference in Hepatic Peroxisome Proliferator-Activated Receptor α Expression: Influence of Pituitary and Gonadal Hormones
M Jalouli, L Carlsson, C Améen, D Lindén, A Ljungberg, L Michalik, S Edén, W Wahli, J Oscarsson
Endocrinology 2003
Cardiac-Specific Overexpression of PPAR alpha Leads to Metabolic and Functional Derangements Similar to the Diabetic Heart
Brian N. Finck, John J. Lehman, Teresa C. Leone, Michael J. Welch, Michael J. Bennett, Attila Kovacs, Xianlin Han, Richard W. Gross, Ray Kozak, Gary D. Lopaschuk, Daniel P. Kelly
Journal of Clinical Investigation 2002
Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells
DM Muoio, JM Way, CJ Tanner, DA Winegar, SA Kliewer, JA Houmard, WE Kraus, GL Dohm
Diabetes 2002
85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells
C Han, AJ Demetris, G Michalopoulos, JH Shelhamer, T Wu
AJP Gastrointestinal and Liver Physiology 2002
Regulatory Networks Controlling Mitochondrial Energy Production in the Developing, Hypertrophied, and Diabetic Heart
B Finck, J Lehman, P Barger, D Kelly
Cold Spring Harbor Symposia on Quantitative Biology 2002
Peroxisome proliferator-activated receptor agonists, hyperlipidaemia, and atherosclerosis
H Vosper, GA Khoudoli, TL Graham, CN Palmer
Pharmacology & Therapeutics 2002
Influence of gender and interleukin-10 deficiency on the inflammatory response during lung infection with Pseudomonas aeruginosa in mice
C Guilbault, P Stotland, C Lachance, M Tam, A Keller, L Thompson-Snipes, E Cowley, TA Hamilton, DH Eidelman, MM Stevenson, D Radzioch
Immunology 2002
Estrogen replacement stimulates fatty acid oxidation and impairs post-ischemic recovery of hearts from ovariectomized female rats
M Grist, RB Wambolt, GP Bondy, DR English, MF Allard
Canadian Journal of Physiology and Pharmacology 2002
Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth
JJ Lehman, DP Kelly
Heart Failure Reviews 2002
Peroxisome Proliferator-activated Receptor α (PPARα) Signaling in the Gene Regulatory Control of Energy Metabolism in the Normal and Diseased Heart
BN Finck, DP Kelly
2002
Estrogen Can Prevent or Reverse Obesity and Diabetes in Mice Expressing Human Islet Amyloid Polypeptide
JG Geisler, W Zawalich, K Zawalich, JR Lakey, H Stukenbrok, AJ Milici, WC Soeller
Diabetes 2002
Peroxisome Proliferator-Activated Receptor-  Coactivator-1 Gene Locus: Associations With Obesity Indices in Middle-Aged Women
H Esterbauer, H Oberkofler, V Linnemayr, B Iglseder, M Hedegger, P Wolfsgruber, B Paulweber, G Fastner, F Krempler, W Patsch
Diabetes 2002
Has Angiogenesis Been Invited to the PPARty?
PM Barger
Journal of Molecular and Cellular Cardiology 2002
Liver Fatty Acid-binding Protein Targets Fatty Acids to the Nucleus: REAL TIME CONFOCAL AND MULTIPHOTON FLUORESCENCE IMAGING IN LIVING CELLS
H Huang, O Starodub, A McIntosh, AB Kier, F Schroeder
The Journal of biological chemistry 2002
Fatty Acid Homeostasis and Induction of Lipid Regulatory Genes in Skeletal Muscles of Peroxisome Proliferator-activated Receptor (PPAR) α Knock-out Mice: EVIDENCE FOR COMPENSATORY REGULATION BY PPARδ
DM Muoio, PS MacLean, DB Lang, S Li, JA Houmard, JM Way, DA Winegar, JC Corton, GL Dohm, WE Kraus
The Journal of biological chemistry 2002
Down-regulation of acyl-CoA oxidase gene expression and increased NF-κB activity in etomoxir-induced cardiac hypertrophy
À Cabrero, M Merlos, JC Laguna, MV Carrera
Journal of lipid research 2002
Gender difference in the leptin response to feeding in peroxisome-proliferator-activated receptor-alpha knockout mice
MS Lewitt, K Brismar
International Journal of Obesity 2002
Phenotypic variability among first-degree relatives with carnitine palmitoyltransferase II deficiency
GD Vladutiu, MJ Bennett, NM Fisher, D Smail, R Boriack, J Leddy, DR Pendergast
Muscle & Nerve 2002
Peroxisome Proliferator–Activated Receptor α Gene Regulates Left Ventricular Growth in Response to Exercise and Hypertension
Y Jamshidi, HE Montgomery, HW Hense, SG Myerson, IP Torra, B Staels, MJ World, A Doering, J Erdmann, C Hengstenberg, SE Humphries, H Schunkert, DM Flavell
Circulation 2002
Pleiotropic Actions of Peroxisome Proliferator–Activated Receptors in Lipid Metabolism and Atherosclerosis
O Barbier, IP Torra, Y Duguay, C Blanquart, JC Fruchart, C Glineur, B Staels
Arteriosclerosis, thrombosis, and vascular biology 2002
Peroxisome proliferator-activated receptor alpha deficiency reduces insulin resistance and atherosclerosis in apoE null mice
Karen Tordjman, Carlos Bernal-Mizrachi, Laura Zemany, Sherry Weng, Chu Feng, Fengjuan Zhang, Teresa C. Leone, Trey Coleman, Daniel P. Kelly, Clay F. Semenkovich
Journal of Clinical Investigation 2001
Effects of ovarian hormones on exercise metabolism
SE Campbell, MA Febbraio
Current Opinion in Clinical Nutrition and Metabolic Care 2001
Alternations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17β-estradiol or a peroxisome proliferator
K Toda, K Takeda, S Akira, T Saibara, T Okada, S Onishi, Y Shizuta
The Journal of Steroid Biochemistry and Molecular Biology 2001
Sex differences in carbohydrate metabolism
MA Tarnopolsky, BC Ruby
Current Opinion in Clinical Nutrition and Metabolic Care 2001
Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice
MS Lewitt, K Brismar, J Wang, IL Wivall-Helleryd, P Sindelar, FJ Gonzalez, T Bergman, GA Bobek
Growth Hormone & IGF Research 2001
Peroxisome Proliferator-Activated Receptors
A Elbrecht, A Adams, DE Moller
2001
PPAR- -Null Mice Are Protected From High-Fat Diet-Induced Insulin Resistance
M Guerre-Millo, C Rouault, P Poulain, J Andre, V Poitout, JM Peters, FJ Gonzalez, JC Fruchart, G Reach, B Staels
Diabetes 2001
Prolonged Inhibition of Muscle Carnitine Palmitoyltransferase-1 Promotes Intramyocellular Lipid Accumulation and Insulin Resistance in Rats
RL Dobbins, LS Szczepaniak, B Bentley, V Esser, J Myhill, JD McGarry
Diabetes 2001
Peroxisome Proliferator-activated Receptors in Atherosclerosis and Inflammation—An Update
CS Elangbam, RD Tyler, RM Lightfoot
Toxicologic pathology 2001
Antagonism of the Actions of Peroxisome Proliferator-activated Receptor-α by Bile Acids
CJ Sinal, M Yoon, FJ Gonzalez
The Journal of biological chemistry 2001
p38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α: A POTENTIAL ROLE IN THE CARDIAC METABOLIC STRESS RESPONSE
PM Barger, AC Browning, AN Garner, DP Kelly
The Journal of biological chemistry 2001
A Role for Peroxisome Proliferator-activated Receptor α (PPARα) in the Control of Cardiac Malonyl-CoA Levels: REDUCED FATTY ACID OXIDATION RATES AND INCREASED GLUCOSE OXIDATION RATES IN THE HEARTS OF MICE LACKING PPARα ARE ASSOCIATED WITH HIGHER CONCENTRATIONS OF MALONYL-CoA AND REDUCED EXPRESSION OF MALONYL-CoA DECARBOXYLASE
FM Campbell, R Kozak, A Wagner, JY Altarejos, JR Dyck, DD Belke, DL Severson, DP Kelly, GD Lopaschuk
The Journal of biological chemistry 2001
Peroxisome Proliferator-activated Receptor-γ Ligands Inhibit Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity
J Berger, M Tanen, A Elbrecht, A Hermanowski-Vosatka, DE Moller, SD Wright, R Thieringer
The Journal of biological chemistry 2001
Hypoxia Inhibits the Peroxisome Proliferator-activated Receptor α/ Retinoid X Receptor Gene Regulatory Pathway in Cardiac Myocytes: A MECHANISM FOR O 2 -DEPENDENT MODULATION OF MITOCHONDRIAL FATTY ACID OXIDATION
JM Huss, FH Levy, DP Kelly
The Journal of biological chemistry 2001
Peroxisome Proliferator-activated Receptor-α Regulates Lipid Homeostasis, but Is Not Associated with Obesity: STUDIES WITH CONGENIC MOUSE LINES
TE Akiyama, CJ Nicol, C Fievet, B Staels, JM Ward, J Auwerx, SS Lee, FJ Gonzalez, JM Peters
The Journal of biological chemistry 2001
Short-term 17β-estradiol decreases glucose R a but not whole body metabolism during endurance exercise
S Carter, S McKenzie, M Mourtzakis, DJ Mahoney, MA Tarnopolsky
Journal of applied physiology 2001
Substrate utilization during endurance exercise in men and women after endurance training
SL Carter, C Rennie, MA Tarnopolsky
American journal of physiology. Endocrinology and metabolism 2001
Peroxisome proliferator-activated receptor-α ligands inhibit cardiac lipoprotein lipase activity
R Carroll, DL Severson
American journal of physiology. Heart and circulatory physiology 2001
Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
SE Campbell, MA Febbraio
American journal of physiology. Endocrinology and metabolism 2001
Endocrine Regulation of Exercise Substrate Utilization in Women Compared to Men:
B Braun, T Horton
Exercise and Sport Sciences Reviews 2001
Myocardial Akt Activation and Gender: Increased Nuclear Activity in Females Versus Males
D Camper-Kirby, S Welch, A Walker, I Shiraishi, KD Setchell, E Schaefer, J Kajstura, P Anversa, MA Sussman
Circulation research 2001
PPARα deficiency increases secretion and serum levels of apolipoprotein B-containing lipoproteins
D Lindén, M Alsterholm, H Wennbo, J Oscarsson
Journal of lipid research 2001
Bezafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue
M Vázquez, N Roglans, A Cabrero, C Rodríguez, T Adzet, M Alegret, R M Sánchez, J C Laguna
Molecular and Cellular Biochemistry 2001
Deactivation of the peroxisome proliferation-activated receptor alpha during cardiac myocyte hypertrophic growth
Philip M. Barger, Jon M. Brandt, Teresa C. Leone, Carla J. Weinheimer, Daniel P. Kelly
Journal of Clinical Investigation 2000
Altered expression of fatty acid–metabolizing enzymes in aromatase-deficient mice
Y Nemoto, K Toda, M Ono, K Fujikawa-Adachi, T Saibara, S Onishi, H Enzan, T Okada, Y Shizuta
Journal of Clinical Investigation 2000
Regulation of Lipid and Lipoprotein Metabolism by PPAR Activators
P Gervois, IP Torra, JC Fruchart, B Staels
Clinical Chemistry and Laboratory Medicine 2000
Peroxisome proliferator-activated receptors: insight into multiple cellular functions
P Escher, W Wahli
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2000
Frequency of stromal lineage colony forming units in bone marrow of peroxisome proliferator-activated receptor-α-null mice
X Wu, JM Peters, FJ Gonzalez, HS Prasad, MD Rohrer, JM Gimble
Bone 2000
Peroxisome proliferator-activated receptors in the cardiovascular system
D Bishop-Bailey
British Journal of Pharmacology 2000
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
RB Vega, JM Huss, DP Kelly
Molecular and cellular biology 2000
Less Extrahepatic Induction of Fatty Acid β-Oxidation Enzymes by PPARα
WS Cook, AV Yeldandi, MS Rao, T Hashimoto, JK Reddy
Biochemical and Biophysical Research Communications 2000
Genomics of the Human Carnitine Acyltransferase Genes
FR van der Leij, NC Huijkman, C Boomsma, JR Kuipers, B Bartelds
Molecular Genetics and Metabolism 2000
PPARα Agonists Reduce 11β-Hydroxysteroid Dehydrogenase Type 1 in the Liver
A Hermanowski-Vosatka, D Gerhold, SS Mundt, VA Loving, M Lu, Y Chen, A Elbrecht, M Wu, T Doebber, L Kelly, D Milot, Q Guo, PR Wang, M Ippolito, YS Chao, SD Wright, R Thieringer
Biochemical and Biophysical Research Communications 2000
The human peroxisome proliferator-activated receptor ?? gene: identification and functional characterization of two natural allelic variants
A Sapone, JM Peters, S Sakai, S Tomita, SS Papiha, R Dai, FK Friedman, FJ Gonzalez
Pharmacogenetics 2000
Regulation of Fatty Acid Transport Protein and Mitochondrial and Peroxisomal β-Oxidation Gene Expression by Fatty Acids in Developing Rats
F Ouali, F Djouadi, C Merlet-Bénichou, B Riveau, J Bastin
Pediatric Research 2000
Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes
À Cabrero, M Alegret, RM Sánchez, T Adzet, JC Laguna, M Vázquez
FEBS Letters 2000
Le rôle de ses activateurs dans la régulation de l'expression des gènes impliqués dans le métabolisme des lipoprotéines, l'inflammation vasculaire et l'athérosclérose
P Duriez, B Staels, JC Fruchart
Annales de l'Institut Pasteur/Actualit�s 2000
Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis
BP Neve, JC Fruchart, B Staels
Biochemical Pharmacology 2000
Etomoxir-induced PPARα-modulated enzymes protect during acute renal failure
D Portilla, G Dai, JM Peters, FJ Gonzalez, MD Crew, AD Proia
American journal of physiology. Renal physiology 2000
Molecular scanning of the human PPARα gene: association of the L162V mutation with hyperapobetalipoproteinemia
MC Vohl, P Lepage, D Gaudet, CG Brewer, C Bétard, P Perron, G Houde, C Cellier, JM Faith, JP Després, K Morgan, TJ Hudson
Journal of lipid research 2000
Regulation of the Liver Fatty Acid-binding Protein Gene by Hepatocyte Nuclear Factor 1α (HNF1α)
TE Akiyama, JM Ward, FJ Gonzalez
The Journal of biological chemistry 2000
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
S Kersten, J Seydoux, JM Peters, FJ Gonzalez, B Desvergne, W Wahli
Journal of Clinical Investigation 1999
Peroxisome proliterator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
JC Fruchart, P Duriez, B Staels
Current Opinion in Lipidology 1999
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
TC Leone, CJ Weinheimer, DP Kelly
Proceedings of the National Academy of Sciences 1999
Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions
L Michalik, W Wahli
Current Opinion in Biotechnology 1999
Etomoxir, Sodium 2-[6-(4-Chlorophenoxy)hexyl]oxirane-2-carboxylate, Up-Regulates Uncoupling Protein-3 mRNA Levels in Primary Culture of Rat Preadipocytes
À Cabrero, M Alegret, R Sánchez, T Adzet, JC Laguna, M Vázquez
Biochemical and Biophysical Research Communications 1999
Peroxisome proliferator-activated receptors: mediators of a fast food impact on gene regulation
L Gelman, J Auwerx
Current Opinion in Clinical Nutrition and Metabolic Care 1999
Inhibition of Adipogenesis by a COOH-Terminally Truncated Mutant of PPARγ2 in 3T3-L1 Cells
J Masugi, Y Tamori, M Kasuga
Biochemical and Biophysical Research Communications 1999
The role of the peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac lipid metabolism
F Djouadi, JM Brandt, CJ Weinheimer, TC Leone, FJ Gonzalez, DP Kelly
Prostaglandins, Leukotrienes and Essential Fatty Acids 1999
A critical role for the peroxisome proliferator-activated receptor   (PPAR ) in the cellular fasting response: The PPAR -null mouse as a model of fatty acid oxidation disorders
TC Leone, CJ Weinheimer, DP Kelly
Proceedings of the National Academy of Sciences 1999
Peroxisome proliferator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging
SA Kliewer, SS Sundseth, SA Jones, PJ Brown, GB Wisely, CS Koble, P Devchand, W Wahli, TM Willson, JM Lenhard, JM Lehmann
Current Opinion in Lipidology 1999
Chromosomal, in silico and in vitro Expression Analysis of Cardiovascular-based Genes Encoding Zinc Finger Proteins
KS Dai, CC Liew
Journal of Molecular and Cellular Cardiology 1999
Evidence for a Novel Cardiac-enriched Retinoid X Receptor Partner
S Cresci, ML Clabby, DP Kelly
The Journal of biological chemistry 1999
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
B Desvergne, W Wahli
Endocrine reviews 1999
Orphan Nuclear Receptors: From Gene to Function*
V Giguère
Endocrine reviews 1999
Advances in Molecular and Cell Biology
KJ Clemetson
Advances in Molecular and Cell Biology 1997
Developmental and hormonal regulation of sarcomeric myosin heavy chain gene family
PM Barger, DP Kelly
Circulation research 1987

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