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Citations to this article

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
Barbara Rehermann
Barbara Rehermann
Published July 1, 2009
Citation Information: J Clin Invest. 2009;119(7):1745-1754. https://doi.org/10.1172/JCI39133.
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Science in Medicine Article has an altmetric score of 4

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

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Abstract

Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been made in our understanding of its life cycle and interaction with the host immune system. Much has been learned from HCV itself, which, via decades of coevolution, gained an intricate knowledge of host innate and adaptive immune responses and developed sophisticated ways to preempt, subvert, and antagonize them. This review discusses the clinical, virological, and immunological features of acute and chronic hepatitis C and the role of the immune response in spontaneous and treatment-induced HCV clearance.

Authors

Barbara Rehermann

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 1 9 2 8 11 5 7 12 15 18 18 25 40 35 29 18 2 255
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2017 (15)

Title and authors Publication Year
Innate and Adaptive Immune Responses in Chronic HCV Infection
LB Dustin
Current drug targets 2017
Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo
N Bhattarai, JH McLinden, J Xiang, MM Mathahs, WN Schmidt, TM Kaufman, JT Stapleton, TL Tellinghuisen
PLoS pathogens 2017
Quasispecies of Hepatitis C Virus Participate in Cell-Specific Infectivity
T Fukuhara, S Yamamoto, C Ono, S Nakamura, D Motooka, H Mori, T Kurihara, A Sato, T Tamura, T Motomura, T Okamoto, M Imamura, T Ikegami, T Yoshizumi, Y Soejima, Y Maehara, K Chayama, Y Matsuura
Scientific Reports 2017
Hepatitis C virus impairs natural killer cell activity via viral serine protease NS3
CM Yang, JC Yoon, JH Park, JM Lee, R Ray
PloS one 2017
Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone
ML Cramer, G Shao, LR Rodino-Klapac, LG Chicoine, PT Martin
Human Gene Therapy 2017
Spontaneous Viral Load Decline and Subsequent Clearance of Chronic Hepatitis C Virus in Postpartum Women Correlates With Favorable Interleukin-28B Gene Allele
M Hashem, R Jhaveri, DA Saleh, SA Sharaf, F El-Mougy, L Abdelsalam, MD Shardell, H El-Ghazaly, SS El-Kamary
Clinical Infectious Diseases 2017
Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C
R López-Rodríguez, Á Hernández-Bartolomé, MJ Borque, Y Rodríguez-Muñoz, S Martín-Vílchez, L García-Buey, L González-Moreno, Y Real-Martínez, PM de Rueda, J Salmerón, JR Vidal-Castiñeira, C López-Larrea, L Rodrigo, R Moreno-Otero, P Sanz-Cameno, MA Avila
PloS one 2017
A Practical Model Evaluating Antiviral Cytokines by Natural Killer Cells in Treatment Naïve Patients with Chronic Hepatitis B Virus Infection
X Li, Y Gu, X Guo, L Gu, L Zhou, X Wu, X Wang, Z Stamataki, Y Huang
Scientific Reports 2017
Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri
ME Kayesh, S Ezzikouri, T Sanada, H Chi, Y Hayashi, K Rebbani, B Kitab, A Matsuu, N Miyoshi, T Hishima, M Kohara, K Tsukiyama-Kohara
Scientific Reports 2017
CD56 bright NK IL-7Rα expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections
CJ Judge, L Kostadinova, KE Sherman, AA Butt, Y Falck-Ytter, NT Funderburg, AL Landay, MM Lederman, SF Sieg, JK Sandberg, DD Anthony
Journal of leukocyte biology 2017
Interaction effects among IFN-γ+874, IL-2-330, IL-10-1082, IL-10-592 and IL-4-589 polymorphisms on the clinical progression of subjects infected with hepatitis B virus and/or hepatitis C virus: a retrospective nested case–control study
QJ Gao, JX Xie, LM Wang, Q Zhou, SY Zhang
BMJ Open 2017
Modulation of Hepatitis C Virus-Specific CD8 Effector T-Cell Function with Antiviral Effect in Infectious Hepatitis C Virus Coculture Model
K Ojiro, X Qu, H Cho, JJ Park, A Vuidepot, N Lissin, PE Molloy, A Bennett, BK Jakobsen, DE Kaplan, JL Riley, KM Chang, JH Ou
Journal of virology 2017
Authentic Patient-Derived Hepatitis C Virus Infects and Productively Replicates in Primary CD4 + and CD8 + T Lymphocytes In Vitro
G Skardasi, AY Chen, TI Michalak, JH Ou
Journal of virology 2017
Three variants in the nicotinamide adenine dinucleotide phosphate oxidase complex are associated with HCV-related liver damage: Page et al
SJ Page, MM Rivera, DE Kleiner, X Zhao, S Auh, EF Remmers, T Heller
Hepatology Communications 2017
Current therapy for chronic hepatitis C: The role of direct-acting antivirals
G Li, ED Clercq
Antiviral Research 2017

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