Citations to this article

New roles revealed for T cells and DCs in glomerulonephritis
Alfred H.J. Kim, … , Mary A. Markiewicz, Andrey S. Shaw
Alfred H.J. Kim, … , Mary A. Markiewicz, Andrey S. Shaw
Published April 20, 2009
Citation Information: J Clin Invest. 2009;119(5):1074-1076. https://doi.org/10.1172/JCI39071.
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Commentary

New roles revealed for T cells and DCs in glomerulonephritis

Abstract

Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex–mediated complement activation, and the presence of autoantibodies made identifying T cell–specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a novel, transgenic murine model of GN, demonstrating a direct role for CD8+ T cells, activated CD4+ T cells, and DCs in the pathogenesis of GN (see the related article, doi:10.1172/JCI38399).

Authors

Alfred H.J. Kim, Mary A. Markiewicz, Andrey S. Shaw

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Citations to this article (7)

Title and authors Publication Year
CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis
Xu X, Qu S, Zhang C, Zhang M, Qin W, Ren G, Bao H, Li L, Zen K, Liu Z 		Advanced Science 2023
Immunosenescence: an unexplored role in glomerulonephritis
Van Laecke S, Van Damme K, Dendooven A 		IBMS BoneKEy 2022
CCL17-producing cDC2 are essential in end-stage lupus nephritis and averted by a parasitic infection
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E Grywalska, I Smarz-Widelska, I Korona-Głowniak, S Mertowski, K Gosik, A Hymos, J Ludian, P Niedźwiedzka-Rystwej, J Roliński, W Załuska 		International journal of molecular sciences 2020
Role of Myeloid-Derived Suppressor Cells in Glucocorticoid-Mediated Amelioration of FSGS
L Li, T Zhang, W Diao, F Jin, L Shi, J Meng, H Liu, J Zhang, CH Zeng, MC Zhang, S Liang, Y Liu, CY Zhang, Z Liu, K Zen 		Journal of the American Society of Nephrology : JASN 2015
A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells
M Cai, J Wu, C Mao, J Ren, P Li, X Li, J Zhong, C Xu, T Zhou 		Journal of Translational Medicine 2013
Activated CD4+ T Cells Target Mesangial Antigens and Initiate Glomerulonephritis
Scindia Y, Nackiewicz D, Dey P, Szymula A, Bajwa A, Rosin D, Bolton WK, Okusa M, Deshmukh U, Bagavant H 		Nephron. Experimental nephrology 2012

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