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Citations to this article

Coadaptation of Helicobacter pylori and humans: ancient history, modern implications
John C. Atherton, Martin J. Blaser
John C. Atherton, Martin J. Blaser
Published September 1, 2009
Citation Information: J Clin Invest. 2009;119(9):2475-2487. https://doi.org/10.1172/JCI38605.
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Coadaptation of Helicobacter pylori and humans: ancient history, modern implications

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Abstract

Humans have been colonized by Helicobacter pylori for at least 50,000 years and probably throughout their evolution. H. pylori has adapted to humans, colonizing children and persisting throughout life. Most strains possess factors that subtly modulate the host environment, increasing the risk of peptic ulceration, gastric adenocarcinoma, and possibly other diseases. H. pylori genes encoding these and other factors rapidly evolve through mutation and recombination, changing the bacteria-host interaction. Although immune and physiologic responses to H. pylori also contribute to pathogenesis, humans have evolved in concert with the bacterium, and its recent absence throughout the life of many individuals has led to new human physiological changes. These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases.

Authors

John C. Atherton, Martin J. Blaser

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 9 3 6 11 18 12 17 15 16 16 24 27 20 29 20 11 3 257
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Toxins 2017
Non-pylori Helicobacters (NHPHs) Induce Shifts in Gastric Microbiota in Helicobacter pylori-Infected Patients
X Peng, L Zhou, Y Gong, Z Song, L He, S Lin, J Zhang
Frontiers in microbiology 2017
Prevalence and characteristics of Epstein–Barr virus-associated gastric carcinomas in Portugal
C Nogueira, M Mota, R Gradiz, MA Cipriano, F Caramelo, H Cruz, A Alarcão, FC Sousa, F Oliveira, F Martinho, JM Pereira, P Figueiredo, M Leitão
Infectious agents and cancer 2017
Effect of treatment failure on the CagA EPIYA motif in Helicobacter pylori strains from Colombian subjects
JA Bustamante-Rengifo, AJ Matta, AJ Pazos, LE Bravo
World journal of gastroenterology : WJG 2017
Gastric microbiome of Indian patients with Helicobacter pylori infection, and their interaction networks
A Das, V Pereira, S Saxena, TS Ghosh, D Anbumani, S Bag, B Das, GB Nair, P Abraham, SS Mande
Scientific Reports 2017
Gut microbiome: a new player in gastrointestinal disease
G Gorkiewicz, A Moschen
Virchows Archiv 2017
Investigation of Helicobacter pylori infection among symptomatic children in Hangzhou from 2007 to 2014: a retrospective study with 12,796 cases
X Shu, M Ping, G Yin, M Jiang
PeerJ 2017
Helicobacter pylori controls NLRP3 expression by regulating hsa-miR-223-3p and IL-10 in cultured and primary human immune cells
SK Pachathundikandi, S Backert
Innate immunity 2017
An Overview of Helicobacter pylori VacA Toxin Biology
N Foegeding, R Caston, M McClain, M Ohi, T Cover
Toxins 2016
Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis
B Kronsteiner, J Bassaganya-Riera, C Philipson, M Viladomiu, A Carbo, V Abedi, R Hontecillas
Gut microbes 2016
Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells
K Hussain, DP Letley, AB Greenaway, R Kenefeck, JA Winter, W Tomlinson, J Rhead, E Staples, K Kaneko, JC Atherton, K Robinson
Frontiers in immunology 2016
Structural organization of membrane-inserted hexamers formed by Helicobacter pylori VacA toxin: VacA oligomerizes into hexamers on membranes
TM Pyburn, NJ Foegeding, C González-Rivera, NA McDonald, KL Gould, TL Cover, MD Ohi
Molecular Microbiology 2016
Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice
SO Reber, PH Siebler, NC Donner, JT Morton, DG Smith, JM Kopelman, KR Lowe, KJ Wheeler, JH Fox, JE Hassell, BN Greenwood, C Jansch, A Lechner, D Schmidt, N Uschold-Schmidt, AM Füchsl, D Langgartner, FR Walker, MW Hale, GL Perez, WV Treuren, A González, AL Halweg-Edwards, M Fleshner, CL Raison, GA Rook, SD Peddada, R Knight, CA Lowry
Proceedings of the National Academy of Sciences 2016
The Gut Microbiome and Obesity
GK John, GE Mullin
Current Oncology Reports 2016
Structural insight into β-Clamp and its interaction with DNA Ligase in Helicobacter pylori
P Pandey, KF Tarique, M Mazumder, SA Rehman, N kumari, S Gourinath
Scientific Reports 2016
The Immune Battle against Helicobacter pylori Infection: NO Offense
AP Gobert, KT Wilson
Trends in Microbiology 2016
The Helicobacter pylori Cag Pathogenicity Island Protein Cag1 is Associated with the Function of T4SS
X Wang, F Ling, H Wang, M Yu, H Zhu, C Chen, J Qian, C Liu, Y Zhang, S Shao
Current Microbiology 2016
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains
J Lind, S Backert, R Hoffmann, J Eichler, Y Yamaoka, GI Perez-Perez, J Torres, H Sticht, N Tegtmeyer
BMC Microbiology 2016
Helicobacter pylori and gut microbiota modulate energy homeostasis prior to inducing histopathological changes in mice
Y Khosravi, RM Bunte, KH Chiow, TL Tan, WY Wong, QH Poh, IM Sentosa, SW Seow, AA Amoyo, S Pettersson, MF Loke, J Vadivelu
Gut microbes 2016
Helicobacter pylori in children with asthmatic conditions at school age, and their mothers
WJ Hollander, AM der Voort, IL Holster, JC de Jongste, VW Jaddoe, A Hofman, GI Perez-Perez, HA Moll, MJ Blaser, L Duijts, EJ Kuipers
Alimentary Pharmacology & Therapeutics 2016
A Nonoligomerizing Mutant Form of Helicobacter pylori VacA Allows Structural Analysis of the p33 Domain
C González-Rivera, AM Campbell, SA Rutherford, TM Pyburn, NJ Foegeding, TL Barke, BW Spiller, MS McClain, MD Ohi, DB Lacy, TL Cover, SR Blanke
Infection and immunity 2016
Helicobacter pylori colonization and pregnancies complicated by preeclampsia, spontaneous prematurity, and small for gestational age birth
WJ Hollander, S Schalekamp-Timmermans, IL Holster, VW Jaddoe, A Hofman, HA Moll, GI Perez-Perez, MJ Blaser, EA Steegers, EJ Kuipers
Helicobacter 2016
Effects of Proton Pump Inhibitors on the Gastric Mucosa-Associated Microbiota in Dyspeptic Patients
FP Sterbini, A Palladini, L Masucci, CV Cannistraci, R Pastorino, G Ianiro, F Bugli, C Martini, W Ricciardi, A Gasbarrini, M Sanguinetti, G Cammarota, B Posteraro, PD Schloss
Applied and environmental microbiology 2016
Commensals and Foodborne Pathogens can Arbitrate Epithelial-carcinogenesis
Y Woappi, O Singh
British microbiology research journal 2016
Helicobacter pylori Adaptation In Vivo in Response to a High-Salt Diet
JT Loh, JA Gaddy, HM Algood, S Gaudieri, S Mallal, TL Cover, SR Blanke
Infection and immunity 2015
Expression of the Helicobacter pylori virulence factor vacuolating cytotoxin A ( vacA ) is influenced by a potential stem-loop structure in the 5′ untranslated region of the transcript: Expression of H. pylori vacA
KR Amilon, DP Letley, JA Winter, K Robinson, JC Atherton
Molecular Microbiology 2015
Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies
K Robinson
Diseases 2015
Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors
SK Pachathundikandi, J Lind, N Tegtmeyer, EM El-Omar, S Backert
BioMed Research International 2015
Helicobacter pylori neutrophil-activating protein: a potential Treg modulator suppressing allergic asthma?
A Sehrawat, S Sinha, A Saxena
Frontiers in microbiology 2015
Molecular Evidence of Helicobacter Pylori Infection in Prostate Tumors
Mohammed S. Al-Marhoon, Allal Ouhtit, Aisha O. Al-Abri, Krishna P. Venkiteswaran, Qassim Al-Busaidi, Josephkunju Mathew, Ibrahim Al-Haddabi, Omar Shareef, Shahid Aquil, Khalid Rahman, Intisar Al-Hashmi, Ishita Gupta, Shyam S. Ganguly
Current Urology 2015
Sialylation of Helicobacter bizzozeronii lipopolysaccharides modulates Toll-like receptor (TLR) 2 mediated response
PK Kondadi, J Revez, ML Hänninen, M Rossi
Veterinary Research 2015
Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis
KW Cook, J Crooks, K Hussain, K O’Brien, M Braitch, H Kareem, CS Constantinescu, K Robinson, B Gran
Frontiers in microbiology 2015
Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity
P Jha, D Lu, Y Yuan, S Xu
Molecular Genetics and Genomics 2015
Elevated levels of adaption in Helicobacter pylori genomes from Japan; a link to higher incidences of gastric cancer?
MJ Soto-Giron, OE Ospina, SE Massey
Evolution, Medicine, and Public Health 2015
Reflux esophagitis triggered after Helicobacter pylori eradication: a noteworthy demerit of eradication therapy among the Japanese?
K Iijima, T Koike, T Shimosegawa
Frontiers in microbiology 2015
Geographic differences in low-dose aspirin-associated gastroduodenal mucosal injury
K Iijima
World journal of gastroenterology : WJG 2015
Worldwide Population Structure, Long-Term Demography, and Local Adaptation of Helicobacter pylori
V Montano, X Didelot, M Foll, B Linz, R Reinhardt, S Suerbaum, Y Moodley, JD Jensen
Genetics 2015
The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence
KP Haley, AG Delgado, MB Piazuelo, BL Mortensen, P Correa, SM Damo, WJ Chazin, EP Skaar, JA Gaddy, SR Blanke
Infection and immunity 2015
Kyoto global consensus report on Helicobacter pylori gastritis
K Sugano, J Tack, EJ Kuipers, DY Graham, EM El-Omar, S Miura, K Haruma, M Asaka, N Uemura, P Malfertheiner
Gut 2015
Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes
K Robinson, J White, J Winter
Journal of inflammation research 2015
Repressed TGF-β signaling through CagA-Smad3 interaction as pathogenic mechanisms of Helicobacter pylori-associated gastritis
TT Nguyen, SJ Kim, JM Park, KB Hahm, HJ Lee
Journal of Clinical Biochemistry and Nutrition 2015
Metalloregulation of Helicobacter pylori physiology and pathogenesis
KP Haley, JA Gaddy
Frontiers in microbiology 2015
Use of Alignment-Free Phylogenetics for Rapid Genome Sequence-Based Typing of Helicobacter pylori Virulence Markers and Antibiotic Susceptibility
AH van Vliet, JG Kusters, DJ Diekema
Journal of clinical microbiology 2015
Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela
M Contreras, M Fernandez-Delgado, N Reyes, MA Garcia-Amado, H Rojas, F Michelangeli
The American journal of tropical medicine and hygiene 2015
Helicobacter pylori : Effect of coexisting diseases and update on treatment regimens
SS Chang
World journal of gastrointestinal pharmacology and therapeutics 2015
Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA: HtrA is an essential gene in H. pylori
N Tegtmeyer, Y Moodley, Y Yamaoka, SR Pernitzsch, V Schmidt, FR Traverso, TP Schmidt, R Rad, KG Yeoh, H Bow, J Torres, M Gerhard, G Schneider, S Wessler, S Backert
Molecular Microbiology 2015
Alteration of the Helicobacter pylori membrane proteome in response to changes in environmental salt concentration
BJ Voss, JT Loh, S Hill, KL Rose, WH McDonald, TL Cover
PROTEOMICS – CLINICAL APPLICATIONS 2015
Helicobacter pylori bacteria alter the p53 stress response via Erk-HDM2 pathway
Bhardwaj V, Noto JM, Wei J, Andl C, El-Rifai W, Peek RM, Zaika AI
Oncotarget 2015
Role of the Microbiota in Immunity and Inflammation
Y Belkaid, TW Hand
Cell 2014
Helicobacter pylori antibody patterns in Germany: a cross-sectional population study
A Michel, M Pawlita, H Boeing, L Gissmann, T Waterboer
Gut pathogens 2014
High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model
J Ma, AL Prince, D Bader, M Hu, R Ganu, K Baquero, P Blundell, RA Harris, AE Frias, KL Grove, KM Aagaard
Nature Communications 2014
Helicobacter pylori infection and diabetes: Is it a myth or fact?
C He, Z Yang, NH Lu
World journal of gastroenterology : WJG 2014
Gastric Microbiome and Gastric Cancer:
KM Brawner, CD Morrow, PD Smith
The Cancer Journal 2014
Clinical relevance of cagL gene and virulence genotypes with disease outcomes in a Helicobacter pylori infected population from Iran
A Yadegar, AM Mobarez, M Alebouyeh, T Mirzaei, T Kwok, MR Zali
World Journal of Microbiology and Biotechnology 2014
Exposure to Helicobacter pylori infection in early childhood and the risk of allergic disease and atopic sensitization: a longitudinal birth cohort study
A Amberbir, G Medhin, WE Abegaz, C Hanlon, K Robinson, A Fogarty, J Britton, A Venn, G Davey
Clinical & Experimental Allergy 2014
H. pylori Virulence Factors: Influence on Immune System and Pathology
B Kalali, R Mejías-Luque, A Javaheri, M Gerhard
Mediators of Inflammation 2014
The Role of the Gut Microbiome in the Pathogenesis and Treatment of Obesity
F Okeke, BC Roland, GE Mullin
Global Advances in Health and Medicine 2014
Blood pressure and stature in Helicobacter pylori positive and negative persons
M Kopacova, I Koupil, B Seifert, MS Fendrichova, J Spirkova, V Vorisek, S Rejchrt, T Douda, I Tacheci, J Bures
World journal of gastroenterology : WJG 2014
Age-dependent association among Helicobacter pylori infection, serum pepsinogen levels and immune response of children to live oral cholera vaccine CVD 103-HgR
K Muhsen, R Lagos, MK Reymann, DY Graham, MF Pasetti, MM Levine
PloS one 2014
Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study
AA Memon, NR Hussein, VY Deyi, A Burette, JC Atherton
Journal of clinical microbiology 2014
A Novel Reduction Strategy of Clarithromycin Resistance in Helicobacter pylori
O Tadjrobehkar, H Abdollahi
Jundishapur Journal of Microbiology 2014
Helicobacter pylori virulence and cancer pathogenesis
Y Yamaoka, DY Graham
Future Oncology 2014
Proteomic Characterization of Helicobacter pylori CagA Antigen Recognized by Child Serum Antibodies and Its Epitope Mapping by Peptide Array
J Akada, M Okuda, N Hiramoto, T Kitagawa, X Zhang, S Kamei, A Ito, M Nakamura, T Uchida, T Hiwatani, Y Fukuda, T Nakazawa, Y Kuramitsu, K Nakamura
PloS one 2014
Helicobacter pylori: friend or foe?
SD Malnick, E Melzer, M Attali, G Duek, J Yahav
World journal of gastroenterology : WJG 2014
CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa
KW Cook, DP Letley, RJ Ingram, E Staples, H Skjoldmose, JC Atherton, K Robinson
Gut 2014
Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells
D Bimczok, JY Kao, M Zhang, S Cochrun, P Mannon, S Peter, CM Wilcox, KE Mönkemüller, PR Harris, JM Grams, RD Stahl, PD Smith, LE Smythies
Mucosal Immunology 2014
Time series analysis of gastric acid secretion over a 20-year period in normal Japanese men
K Iijima, T Koike, Y Abe, S Ohara, N Nakaya, T Shimosegawa
Journal of Gastroenterology 2014
Genes Required for Assembly of Pili Associated with the Helicobacter pylori cag Type IV Secretion System
EM Johnson, JA Gaddy, BJ Voss, EE Hennig, TL Cover
Infection and immunity 2014
Analysis of Surface-Exposed Outer Membrane Proteins in Helicobacter pylori
BJ Voss, JA Gaddy, WH McDonald, TL Cover
Journal of bacteriology 2014
Repetitive Sequence Variations in the Promoter Region of the Adhesin-Encoding Gene sabA of Helicobacter pylori Affect Transcription
VC Harvey, CR Acio, AK Bredehoft, L Zhu, DR Hallinger, V Quinlivan-Repasi, SE Harvey, MH Forsyth
Journal of bacteriology 2014
Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention
P Karimi, F Islami, S Anandasabapathy, ND Freedman, F Kamangar
Cancer epidemiology, biomarkers & prevention 2014
Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city
WJ Hollander, IL Holster, B Gilst, AJ van Vuuren, VW Jaddoe, A Hofman, GI Perez-Perez, EJ Kuipers, HA Moll, MJ Blaser
Gut 2014
Helicobacter pylori Membrane Vesicles Stimulate Innate Pro- and Anti-Inflammatory Responses and Induce Apoptosis in Jurkat T Cells
J Winter, D Letley, J Rhead, J Atherton, K Robinson, SR Blanke
Infection and immunity 2014
Differentiation of non-pylori Helicobacter species based on PCR-restriction fragment length polymorphism of the 23S rRNA gene.
Yadegar A, Alebouyeh M, Lawson AJ, Mirzaei T, Nazemalhosseini Mojarad E, Zali MR
World Journal of Microbiology & Biotechnology 2014
DNA transfer in the gastric pathogen Helicobacter pylori.
Fernandez-Gonzalez E, Backert S
Journal of Gastroenterology 2014
Diet, microbial virulence and Helicobacter pylori-induced gastric cancer
T Cover, RM Peek
Gut microbes 2013
Comparative genomic analysis of East Asian and non-Asian Helicobacter pylori strains identifies rapidly evolving genes
SS Duncan, PL Valk, MS McClain, CL Shaffer, JA Metcalf, SR Bordenstein, TL Cover
PloS one 2013
Flagellar Localization of a Helicobacter pylori Autotransporter Protein
JN Radin, JA Gaddy, C González-Rivera, JT Loh, HM Algood, TL Cover
mBio 2013
High Dietary Salt Intake Exacerbates Helicobacter pylori-Induced Gastric Carcinogenesis
JA Gaddy, JN Radin, JT Loh, F Zhang, MK Washington, RM Peek, HM Algood, TL Cover, SR Blanke
Infection and immunity 2013
Potential role of Helicobacter pylori infection in nonalcoholic fatty liver disease
M Li, Z Shen, YM Li
World journal of gastroenterology : WJG 2013
Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine
M Stein, P Ruggiero, R Rappuoli, F Bagnoli
Frontiers in immunology 2013
Control of gene expression in Helicobacter pylori using the Tet repressor
MS McClain, SS Duncan, JA Gaddy, TL Cover
Journal of Microbiological Methods 2013
Role of Connexin 43 in Helicobacter pylori VacA-Induced Cell Death
JN Radin, C González-Rivera, AE Frick-Cheng, J Sheng, JA Gaddy, DH Rubin, HM Algood, MS McClain, TL Cover, BA McCormick
Infection and immunity 2013
Animals in a bacterial world, a new imperative for the life sciences
M McFall-Ngai, MG Hadfield, TC Bosch, HV Carey, T Domazet-Loso, AE Douglas, N Dubilier, G Eberl, T Fukami, SF Gilbert, U Hentschel, N King, S Kjelleberg, AH Knoll, N Kremer, SK Mazmanian, JL Metcalf, K Nealson, NE Pierce, JF Rawls, A Reid, EG Ruby, M Rumpho, JG Sanders, D Tautz, JJ Wernegreen
Proceedings of the National Academy of Sciences 2013
Association between Helicobacter pylori and mortality in the NHANES III study
Y Chen, S Segers, MJ Blaser
Gut 2013
Helicobacter pylori downregulates expression of human β-defensin 1 in the gastric mucosa in a type IV secretion-dependent fashion
SR Patel, K Smith, DP Letley, KW Cook, AA Memon, RJ Ingram, E Staples, S Backert, AM Zaitoun, JC Atherton, K Robinson
Cellular Microbiology 2013
Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells
SK Pachathundikandi, N Tegtmeyer, S Backert
Gut microbes 2013
In vitro effect of amoxicillin and clarithromycin on the 3' region of cagA gene in Helicobacter pylori isolates
JA Bustamante-Rengifo, AJ Matta, A Pazos, LE Bravo
World journal of gastroenterology : WJG 2013
Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection
A Carbo, J Bassaganya-Riera, M Pedragosa, M Viladomiu, M Marathe, S Eubank, K Wendelsdorf, K Bisset, S Hoops, X Deng, M Alam, B Kronsteiner, Y Mei, R Hontecillas
PloS one 2013
Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger
N Tegtmeyer, FR Traverso, M Rohde, OA Oyarzabal, N Lehn, W Schneider-Brachert, RL Ferrero, JG Fox, DE Berg, S Backert
PloS one 2013
Characterization of Helicobacter pylori bacteriophage KHP30
J Uchiyama, H Takeuchi, S Kato, K Gamoh, I Takemura-Uchiyama, T Ujihara, M Daibata, S Matsuzaki
Applied and environmental microbiology 2013
Comparative analysis of the full genome of Helicobacter pylori isolate Sahul64 identifies genes of high divergence
W Lu, MJ Wise, CY Tay, HM Windsor, BJ Marshall, C Peacock, T Perkins
Journal of bacteriology 2013
Effect of Caenorhabditis elegans age and genotype on horizontal gene transfer in intestinal bacteria
C Portal-Celhay, K Nehrke, MJ Blaser
The FASEB Journal 2013
Helicobacter pylori Seropositivities and Risk of Pancreatic Carcinoma
HA Risch, L Lu, MS Kidd, J Wang, W Zhang, Q Ni, YT Gao, H Yu
Cancer epidemiology, biomarkers & prevention 2013
Helicobacter pylori Infection in a Pig Model Is Dominated by Th1 and Cytotoxic CD8 + T Cell Responses
B Kronsteiner, J Bassaganya-Riera, C Philipson, M Viladomiu, A Carbo, M Pedragosa, S Vento, R Hontecillas, SR Blanke
Infection and immunity 2013
J-Western Forms of Helicobacter pylori cagA Constitute a Distinct Phylogenetic Group with a Widespread Geographic Distribution
SS Duncan, PL Valk, CL Shaffer, SR Bordenstein, TL Cover
Journal of bacteriology 2012
Helicobacter pylori Colonization Ameliorates Glucose Homeostasis in Mice through a PPAR γ-Dependent Mechanism
J Bassaganya-Riera, MG Dominguez-Bello, B Kronsteiner, A Carbo, P Lu, M Viladomiu, M Pedragosa, X Zhang, BW Sobral, SP Mane, SK Mohapatra, WT Horne, AJ Guri, M Groeschl, G Lopez-Velasco, R Hontecillas, IG Boneca
PloS one 2012
Are infants born by elective cesarean delivery without labor at risk for developing immune disorders later in life?
R Romero, DM Sci, SJ Korzeniewski
American Journal of Obstetrics and Gynecology 2012
Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3γ via Gastric STAT3 Activation
KS Lee, A Kalantzis, CB Jackson, L O'Connor, N Murata-Kamiya, M Hatakeyama, LM Judd, AS Giraud, TR Menheniott
PloS one 2012
The human microbiome: at the interface of health and disease
I Cho, MJ Blaser
Nature Reviews Genetics 2012
Association Between Gastric Helicobacter pylori Colonization and Glycated Hemoglobin Levels
Y Chen, MJ Blaser
The Journal of Infectious Diseases 2012
Germs gone wild
N Hoshi, R Medzhitov
Nature Medicine 2012
How Helicobacter pylori infection controls gastric acid secretion
AJ Smolka, S Backert
Journal of Gastroenterology 2012
A Novel Virulence Strategy for Pseudomonas aeruginosa Mediated by an Autotransporter with Arginine-Specific Aminopeptidase Activity
JC Luckett, O Darch, C Watters, M Abuoun, V Wright, E Paredes-Osses, J Ward, H Goto, S Heeb, S Pommier, KP Rumbaugh, M Cámara, KR Hardie
PLoS pathogens 2012
Alterations in Helicobacter pylori Triggered by Contact with Gastric Epithelial Cells
EM Johnson, JA Gaddy, TL Cover
Frontiers in Cellular and Infection Microbiology 2012
Persistent Helicobacter pylori Specific Th17 Responses in Patients with Past H. pylori Infection Are Associated with Elevated Gastric Mucosal IL-1β
V Serelli-Lee, KL Ling, C Ho, LH Yeong, GK Lim, B Ho, SB Wong
PloS one 2012
An RGD Helper Sequence in CagL of Helicobacter pylori Assists in Interactions with Integrins and Injection of CagA
J Conradi, N Tegtmeyer, M Woźna, M Wissbrock, C Michalek, C Gagell, TL Cover, R Frank, N Sewald, S Backert
Frontiers in Cellular and Infection Microbiology 2012
Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma
HH Cheng, GY Tseng, HB Yang, HJ Wang, HJ Lin, WC Wang
World journal of gastroenterology : WJG 2012
Significant decrease in prevalence of Helicobacter pylori in the Czech Republic
J Bureš, M Kopáčová, I Koupil, B Seifert, MS Fendrichová, J Spirková, V Voříšek, S Rejchrt, T Douda, N Král, I Tachecí
World journal of gastroenterology : WJG 2012
Current Status and Future Perspectives on the Etiology of Esophageal Adenocarcinoma
AP Thrift, N Pandeya, DC Whiteman
Frontiers in Oncology 2012
The Impact of the Gut Microbiota on Human Health: An Integrative View
JC Clemente, LK Ursell, LW Parfrey, R Knight
Cell 2012
Human Microbiome and Cancer: An Insight
S Khurana
Indian Journal of Microbiology 2012
Structural Analysis of the Oligomeric States of Helicobacter pylori VacA Toxin
MG Chambers, TM Pyburn, C González-Rivera, SE Collier, I Eli, CK Yip, Y Takizawa, DB Lacy, TL Cover, MD Ohi
Journal of Molecular Biology 2012
Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)
C Porras, J Nodora, R Sexton, C Ferreccio, S Jimenez, RL Dominguez, P Cook, G Anderson, DR Morgan, LH Baker, ER Greenberg, R Herrero
Cancer Causes & Control 2012
Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells
AP Gobert, T Verriere, T Sablet, RM Peek, R Chaturvedi, KT Wilson
Cellular Microbiology 2012
Equilibria of Humans and Our Indigenous Microbiota Affecting Asthma
MJ Blaser
Proceedings of the American Thoracic Society 2012
Transgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in Drosophila
AM Wandler, K Guillemin
PLoS pathogens 2012
DprB facilitates inter- and intragenomic recombination in Helicobacter pylori
XS Zhang, MJ Blaser
Journal of bacteriology 2012
Natural transformation of an engineered Helicobacter pylori strain deficient in type II restriction endonucleases
XS Zhang, MJ Blaser
Journal of bacteriology 2012
Analysis of Helicobacter pylori cagA Promoter Elements Required for Salt-Induced Upregulation of CagA Expression
JT Loh, DB Friedman, MB Piazuelo, LE Bravo, KT Wilson, RM Peek, P Correa, TL Cover, SR Blanke
Infection and immunity 2012
The Intermediate Region of Helicobacter pylori VacA Is a Determinant of Toxin Potency in a Jurkat T Cell Assay
C González-Rivera, HM Algood, JN Radin, MS McClain, TL Cover, BA McCormick
Infection and immunity 2012
Next-Generation Sequencing and De Novo Assembly, Genome Organization, and Comparative Genomic Analyses of the Genomes of Two Helicobacter pylori Isolates from Duodenal Ulcer Patients in India
N Kumar, AK Mukhopadhyay, R Patra, R De, R Baddam, S Shaik, J Alam, S Tiruvayipati, N Ahmed
Journal of bacteriology 2012
Novel Functions for Glycosyltransferases Jhp0562 and GalT in Lewis Antigen Synthesis and Variation in Helicobacter pylori
MA Pohl, S Kienesberger, MJ Blaser, SR Blanke
Infection and immunity 2012
Is Helicobacter pylori good or bad?
Mishra S
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2012
Microbiome and Malignancy
CS Plottel, MJ Blaser
Cell Host & Microbe 2011
Stromal Regulation of Human Gastric Dendritic Cells Restricts the Th1 Response to H. pylori
D Bimczok, JM Grams, RD Stahl, KB Waites, LE Smythies, PD Smith
Gastroenterology 2011
Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori
S Backert, M Clyne, N Tegtmeyer
Cell communication and signaling : CCS 2011
Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma
SS Kim, VE Ruiz, JD Carroll, SF Moss
Cancer Letters 2011
The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin
F Francois, J Roper, N Joseph, Z Pei, A Chhada, JR Shak, AZ de Perez, GI Perez-Perez, MJ Blaser
BMC Gastroenterology 2011
Molecular cross-talk between Helicobacter pylori and human gastric mucosa
V Ricci, M Romano, P Boquet
World journal of gastroenterology : WJG 2011
Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α
SK Pachathundikandi, S Brandt, J Madassery, S Backert
PloS one 2011
Helicobacter pylori with stronger intensity of CagA phosphorylation lead to an increased risk of gastric intestinal metaplasia and cancer
CH Chuang, HB Yang, SM Sheu, KH Hung, JJ Wu, HC Cheng, WL Chang, BS Sheu
BMC Microbiology 2011
Gastric Infection by Helicobacter pylori
G Sachs, DR Scott, Y Wen
Current Gastroenterology Reports 2011
Novel gastric helicobacters and oral campylobacters are present in captive and wild cetaceans
CG Goldman, MJ Matteo, JD Loureiro, M Almuzara, C Barberis, C Vay, M Catalano, SR Heredia, P Mantero, JR Boccio, MB Zubillaga, GA Cremaschi, JV Solnick, GI Perez-Perez, MJ Blaser
Veterinary Microbiology 2011
HelicoVax: Epitope-based therapeutic H. pylori vaccination in a mouse model
SF Moss, L Moise, DS Lee, W Kim, S Zhang, J Lee, AB Rogers, W Martin, AS de Groot
Vaccine 2011
A Gastric Pathogen Moves Chemotaxis in a New Direction
EG Sweeney, K Guillemin
mBio 2011
Role of the cag pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis
N Tegtmeyer, S Wessler, S Backert
The FEBS journal 2011
Positive selection on a bacterial oncoprotein associated with gastric cancer
G Delgado-Rosado, MG Dominguez-Bello, SE Massey
Gut pathogens 2011
Attenuated CagA Oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon*
M Suzuki, K Kiga, D Kersulyte, J Cok, CC Hooper, H Mimuro, T Sanada, S Suzuki, M Oyama, H Kozuka-Hata, S Kamiya, QM Zou, RH Gilman, DE Berg, C Sasakawa
The Journal of biological chemistry 2011
Genotypic and phenotypic variation of Lewis antigen expression in geographically diverse Helicobacter pylori isolates
MA Pohl, W Zhang, SN Shah, EL Sanabria-Valentín, GI Perez-Perez, MJ Blaser
Helicobacter 2011
Genomes of Two Chronological Isolates (Helicobacter pylori 2017 and 2018) of the West African Helicobacter pylori Strain 908 Obtained from a Single Patient
TS Avasthi, SH Devi, TD Taylor, N Kumar, R Baddam, S Kondo, Y Suzuki, H Lamouliatte, F Megraud, N Ahmed
Journal of bacteriology 2011
Immune Evasion by Helicobacter pylori Is Mediated by Induction of Macrophage Arginase II
ND Lewis, M Asim, DP Barry, T de Sablet, K Singh, MB Piazuelo, AP Gobert, R Chaturvedi, KT Wilson
Journal of immunology (Baltimore, Md. : 1950) 2011
Analysis of cagA in Helicobacter pylori Strains from Colombian Populations with Contrasting Gastric Cancer Risk Reveals a Biomarker for Disease Severity
JT Loh, CL Shaffer, MB Piazuelo, LE Bravo, MS McClain, P Correa, TL Cover
Cancer epidemiology, biomarkers & prevention 2011
Development of the Human Gastrointestinal Microbiota and Insights from High-Throughput Sequencing
Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R
Gastroenterology 2011
Infection with Specific Helicobacter pylori-cag Pathogenicity Island Strains Is Associated with Interleukin-1B Gene Polymorphisms in Venezuelan Chronic Gastritis Patients
MA Chiurillo, YH Moran, M Cañas, EJ Valderrama, E Armanie
Digestive Diseases and Sciences 2010
Molecular Evolution of the Helicobacter pylori Vacuolating Toxin Gene vacA
KA Gangwer, CL Shaffer, S Suerbaum, DB Lacy, TL Cover, SR Bordenstein
Journal of bacteriology 2010
Food allergy: separating the science from the mythology
P Brandtzaeg
Nature Reviews Gastroenterology & Hepatology 2010
Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells
IO Lee, JH Kim, YJ Choi, MH Pillinger, SY Kim, MJ Blaser, YC Lee
The Journal of biological chemistry 2010
Structure of the human gastric bacterial community in relation to Helicobacter pylori status
A Maldonado-Contreras, KC Goldfarb, F Godoy-Vitorino, U Karaoz, M Contreras, MJ Blaser, EL Brodie, MG Dominguez-Bello
The ISME Journal 2010
Helicobacter pylori and esophageal disease: wake-up call?
MJ Blaser
Gastroenterology 2010
Longitudinal analysis of serological responses of adults to Helicobacter pylori antigens
GI Perez-Perez, AM Maw, L Feingold-Link, J Gunn, AL Bowers, C Minano, H Rautelin, TU Kosunen, MJ Blaser
The Journal of Infectious Diseases 2010
Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells
J Wei, TA Nagy, A Vilgelm, E Zaika, SR Ogden, J Romero-Gallo, MB Piazuelo, P Correa, MK Washington, W El-Rifai, RM Peek, A Zaika
Gastroenterology 2010
Helicobacter pylori activation of PARP-1: Usurping a versatile regulator of host cellular health
CW Nossa, SR Blanke
Gut microbes 2010
Host-Interactive Genes in Amerindian Helicobacter pylori Diverge from Their Old World Homologs and Mediate Inflammatory Responses
SP Mane, MG Dominguez-Bello, MJ Blaser, BW Sobral, R Hontecillas, J Skoneczka, SK Mohapatra, OR Crasta, C Evans, T Modise, S Shallom, M Shukla, C Varon, F Mégraud, AL Maldonado-Contreras, KP Williams, J Bassaganya-Riera
Journal of bacteriology 2010
Reconstitution of Helicobacter pylori VacA Toxin from Purified Components
C González-Rivera, KA Gangwer, MS McClain, IM Eli, MG Chambers, MD Ohi, DB Lacy, TL Cover
Biochemistry 2010
Tales from the gene pool: a genomic view of infectious disease
Karen Honey
Journal of Clinical Investigation 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Helicobacter pylori--a seasoned pathogen by any other name
N Ahmed, S Tenguria, N Nandanwar
Gut pathogens 2009

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