RNA virus genomics: a world of possibilities
Edward C. Holmes
Edward C. Holmes
Published September 1, 2009
Citation Information: J Clin Invest. 2009;119(9):2488-2495. https://doi.org/10.1172/JCI38050.
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RNA virus genomics: a world of possibilities

Abstract

The increasing availability of complete genome sequences of RNA viruses has the potential to shed new light on fundamental aspects of their biology. Here, I use case studies of 3 RNA viruses to explore the impact of genomic sequence data, with particular emphasis on influenza A virus. Notably, the studies of RNA virus genomics undertaken to date largely focused on issues of evolution and epidemiology, and they have given these disciplines new impetus. However, genomic data have so far made fewer inroads into areas of more direct importance for disease, prevention, and control; thus, harnessing their full potential remains an important goal.

Authors

Edward C. Holmes

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Figure 2

Genetic diversity of human influenza A/H1N1 virus in the United States during the 2006–2007 influenza season.

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Genetic diversity of human influenza A/H1N1 virus in the United States d...
The phylogenetic tree depicts the diversity of the gene encoding NA in 284 isolates sampled across the United States. Isolates from different geographical locations are color coded according to the inset map. Note that there is remarkable genetic diversity, manifest as the circulation of multiple lineages likely to be independently imported, and that there is no clear spatial patterning, as reflected in the mix of colors. Figure adapted with permission from PLoS Pathogens (14).