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J R Grandis, … , A S Pitt, D J Tweardy
Published October 1, 1998
Citation Information: J Clin Invest. 1998;102(7):1385-1392. https://doi.org/10.1172/JCI3785.
Citation Information: J Clin Invest. 1998;102(7):1385-1392. https://doi.org/10.1172/JCI3785.
Abstract
Stimulation of epidermal growth factor receptor (EGFR) by ligand(s) leads to activation of signaling molecules including Stat1 and Stat3, two members of the signal transducers and activators of transcription (STAT) protein family. Activation of Stat1 and Stat3 was constitutive in transformed squamous epithelial cells, which produce elevated levels of TGF-alpha, and was enhanced by the addition of exogenous TGF-alpha. Targeting of Stat3 using antisense oligonucleotides directed against the translation initiation site, resulted in significant growth inhibition. In addition, cells stably transfected with dominant negative mutant Stat3 constructs failed to proliferate in vitro. In contrast, targeting of Stat1 using either antisense or dominant-negative strategies had no effect on cell growth. Thus, TGF-alpha/EGFR-mediated autocrine growth of transformed epithelial cells is dependent on activation of Stat3 but not Stat1.
Authors
J R Grandis, S D Drenning, A Chakraborty, M Y Zhou, Q Zeng, A S Pitt, D J Tweardy
Total citations by year
Citation information
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|
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|
Exploring Novel Frontiers: Leveraging STAT3 Signaling for Advanced Cancer Therapeutics.
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Cancers | 2024 |
|
Delineating the role of nuclear receptors in colorectal cancer, a focused review
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Discover. Oncology | 2024 |
|
Chemoprevention of head and neck cancer: a review of current approaches and future perspectives
Han S, Bommireddy R, Kim P, Selvaraj P, Shin DM |
Cancer prevention research (Philadelphia, Pa.) | 2024 |
|
Oligonucleotide-Based Therapeutics for STAT3 Targeting in Cancer-Drug Carriers Matter.
Molenda S, Sikorska A, Florczak A, Lorenc P, Dams-Kozlowska H |
Cancers | 2023 |
|
Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers
Ni Y, Low JT, Silke J, O\u2019Reilly LA |
Frontiers in immunology | 2022 |
|
Novel Systemic Treatment Modalities Including Immunotherapy and Molecular Targeted Therapy for Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma
Ghosh S, Shah PA, Johnson FM |
International journal of molecular sciences | 2022 |
|
The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer.
Khatoon E, Hegde M, Kumar A, Daimary UD, Sethi G, Bishyaee A, Kunnumakkara AB |
Archives of Pharmacal Research | 2022 |
|
Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products.
Rahman MM, Sarker MT, Alam Tumpa MA, Yamin M, Islam T, Park MN, Islam MR, Rauf A, Sharma R, Cavalu S, Kim B |
Frontiers in pharmacology | 2022 |
|
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy
M Tolomeo, A Cascio |
International journal of molecular sciences | 2021 |
|
Differences in Extracellular Vesicle Protein Cargo Are Dependent on Head and Neck Squamous Cell Carcinoma Cell of Origin and Human Papillomavirus Status
C Goudsmit, F da Veiga Leprevost, V Basrur, L Peters, A Nesvizhskii, H Walline |
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|
HPV+ve/−ve oral-tongue cancer stem cells: A potential target for relapse-free therapy
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Translational oncology | 2021 |
|
RePhine: An Integrative Method for Identification of Drug Response-related Transcriptional Regulators
Wang X, Zhang Z, Qin W, Liu S, Liu C, Genchev GZ, Hui L, Zhao H, Lu H |
Genomics, Proteomics & Bioinformatics | 2021 |
|
Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck
G van Caloen, S Schmitz, C van Marcke, X Caignet, A Mendola, SP dit Ruys, PP Roger, D Vertommen, JP Machiels |
Cancers | 2021 |
|
Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment
DD Lv, LY Zhou, H Tang |
Experimental & molecular medicine | 2021 |
|
Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition
P Oleksak, M Psotka, M Vancurova, O Sapega, J Bieblova, M Reinis, D Rysanek, R Mikyskova, K Chalupova, D Malinak, J Svobodova, R Andrys, H Rehulkova, V Skopek, PN Lam, J Bartek, Z Hodny, K Musilek |
Journal of Enzyme Inhibition and Medicinal Chemistry | 2021 |
|
Perspectives on natural compounds in chemoprevention and treatment of cancer: an update with new promising compounds
A Haque, D Brazeau, AR Amin |
European Journal of Cancer | 2021 |
|
Interleukin-6 and Interleukin-8 Regulate STAT3 Activation Migration/Invasion and EMT in Chrysophanol-Treated Oral Cancer Cell Lines
PC Hsu, YH Chen, CF Cheng, CY Kuo, HK Sytwu |
Life Sciences | 2021 |
|
Modified natriuretic peptides and their potential role in cancer treatment
M Xu, X Liu, P Li, Y Yang, W Zhang, S Zhao, Y Zeng, X Zhou, L Zeng, G Yang |
Biomedical journal | 2021 |
|
RePhine: An Integrative Method for Identification of Drug Response-related Transcriptional Regulators
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|
Increased accuracy of genomic predictions for growth under chronic thermal stress in rainbow trout by prioritizing variants from GWAS using imputed sequence data
GM Yoshida, JM Yáñez |
Evolutionary Applications | 2021 |
|
Emerging role of signal transducer and activator of transcription 3 (STAT3) in pituitary adenomas
C Liu, T Nakano-Tateno, M Satou, C Chik, T Tateno |
Endocrine Journal | 2021 |
|
Effects and mechanisms of Eps8 on the biological behaviour of malignant tumours (Review)
K Luo, L Zhang, Y Liao, H Zhou, H Yang, M Luo, C Qing |
Oncology reports | 2021 |
|
Modified natriuretic peptides and their potential roles in cancer treatment.
Xu M, Liu X, Li P, Yang Y, Zhang W, Zhao S, Zeng Y, Zhou X, Zeng LH, Yang G |
Biomedical journal | 2021 |
|
Increased accuracy of genomic predictions for growth under chronic thermal stress in rainbow trout by prioritizing variants from GWAS using imputed sequence data.
Yoshida GM, Yáñez JM |
Evolutionary Applications | 2021 |
|
Targeting STAT3 in cancer and autoimmune diseases
T Gharibi, Z Babaloo, A Hosseini, M Abdollahpour-alitappeh, V Hashemi, F Marofi, K Nejati, B Baradaran |
European Journal of Pharmacology | 2020 |
|
Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature
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Seminars in Cancer Biology | 2020 |
|
Human Papillomavirus Infection in Head and Neck Squamous Cell Carcinomas: Transcriptional Triggers and Changed Disease Patterns
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Frontiers in Cellular and Infection Microbiology | 2020 |
|
Stat2 stability regulation: an intersection between immunity and carcinogenesis
CJ Lee, HJ An, ES Cho, HC Kang, JY Lee, HS Lee, YY Cho |
Experimental & molecular medicine | 2020 |
|
Costunolide inhibits osteosarcoma growth and metastasis via suppressing STAT3 signal pathway
X Jin, C Wang, L wang |
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie | 2020 |
|
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S Ren, Y Xing, C Wang, F Jiang, G Liu, Z Li, T Jiang, Y Zhu, D Piao |
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|
STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas�1 expression in U251 cells
G Guo, S Wang, Y Hao, Y Ren, Y Wu, J Zhang, D Liu |
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|
The potential and controversy of targeting STAT family members in cancer
Y Verhoeven, S Tilborghs, J Jacobs, JD Waele, D Quatannens, C Deben, H Prenen, P Pauwels, XB Trinh, A Wouters, EL Smits, F Lardon, PA van Dam |
Seminars in Cancer Biology | 2019 |
|
Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication
CY Loh, A Arya, AF Naema, WF Wong, G Sethi, CY Looi |
Frontiers in Oncology | 2019 |
|
Targeted therapies for non-HPV-related head and neck cancer: challenges and opportunities in the context of predictive, preventive, and personalized medicine
LA Shahoumi, WA Yeudall |
The EPMA Journal | 2019 |
|
TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia
X Dai, J Chen, F Xu, J Zhao, W Cai, Z Sun, TK Hitchens, LM Foley, RK Leak, J Chen, X Hu |
Journal of Cerebral Blood Flow & Metabolism | 2019 |
|
Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma
Z Wang, M Yan, J Li, J Long, Y Li, H Zhang |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2019 |
|
Tumour Microenvironment and Immune Evasion in EGFR Addicted NSCLC: Hurdles and Possibilities
A Santaniello, F Napolitano, A Servetto, PD Placido, N Silvestris, C Bianco, L Formisano, R Bianco |
Cancers | 2019 |
|
Plant and Human Health, Volume 3: Pharmacology and Therapeutic Uses
M Ozturk, KR Hakeem |
2019 | |
|
Expression profile and prognostic values of STAT family members in non-small cell lung cancer
Mengqi Yang, Huanting Chen, Lin Zhou, Kai Chen, Fengxi Su |
American journal of translational research | 2019 |
|
TRIM14 Promotes Breast Cancer Cell Proliferation by Inhibiting Apoptosis
G Hu, W Pen, M Wang |
Oncology research | 2019 |
|
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
DE Johnson, RA O'Keefe, JR Grandis |
Nature Reviews Clinical Oncology | 2018 |
|
Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3
Z Yang, B Xu, X Hu, X Yao, Y Tang, C Qian, S Wang, H Chen, X Bai, J Wu |
Journal of Cellular and Molecular Medicine | 2018 |
|
The role of interleukin‑6‑STAT3 signalling in glioblastoma (Review)
A West, V Tsui, S Stylli, H Nguyen, A Morokoff, A Kaye, R Luwor |
Oncology Letters | 2018 |
|
Dual radiosensitization and anti-STAT3 anti-proliferative strategy based on delivery of gold nanoparticle - oligonucleotide nanoconstructs to head and neck cancer cells
S Zhang, S Gupta, TJ Fitzgerald, AA Bogdanov |
Nanotheranostics | 2018 |
|
Dual radiosensitization and anti-STAT3 anti-proliferative strategy based on delivery of gold nanoparticle - oligonucleotide nanoconstructs to head and neck cancer cells
S Zhang, S Gupta, TJ Fitzgerald, AA Bogdanov |
Nanotheranostics | 2018 |
|
EPS8 signaling as a therapeutic target in oral cancer
A Yeudall, V Patel |
Oral Diseases | 2018 |
|
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AA Bhat, H Lu, M Soutto, A Capobianco, P Rai, A Zaika, W El-Rifai |
Oncogene | 2018 |
|
Molecular Determinants of Head and Neck Cancer
B Burtness, EA Golemis |
2018 | |
|
Rho GTPase Activating Protein 24 (ARHGAP24) Regulates the Anti-Cancer Activity of Sorafenib Against Breast Cancer MDA-MB-231 Cells via the Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway
X Dai, F Geng, J Dai, M Li, M Liu |
Medical science monitor : international medical journal of experimental and clinical research | 2018 |
|
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SK Pindiprolu, PK Chintamaneni, PT Krishnamurthy, KR Ganapathineedi |
Drug Development and Industrial Pharmacy | 2018 |
|
Expression of DEC2 enhances chemosensitivity by inhibiting STAT5A in gastric cancer: LI et al
H Li, X Ma, D Xiao, Y Jia, Y Wang |
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|
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F Concha-Benavente, RL Ferris |
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|
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C Henique, G Bollée, X Loyer, F Grahammer, N Dhaun, M Camus, J Vernerey, L Guyonnet, F Gaillard, H Lazareth, C Meyer, I Bensaada, L Legrès, T Satoh, S Akira, P Bruneval, S Dimmeler, A Tedgui, A Karras, E Thervet, D Nochy, TB Huber, L Mesnard, O Lenoir, PL Tharaux |
Nature Communications | 2017 |
|
Signaling pathways as therapeutic targets in biliary tract cancer
J Yang, MR Farren, D Ahn, T Bekaii-Saab, GB Lesinski |
Expert Opinion on Therapeutic Targets | 2017 |
|
Potential therapeutic targets of Guggulsterone in cancer
AA Bhat, KS Prabhu, S Kuttikrishnan, R Krishnankutty, J Babu, RM Mohammad, S Uddin |
Nutrition & Metabolism | 2017 |
|
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S Sengupta, A Nagalingam, N Muniraj, MY Bonner, P Mistriotis, A Afthinos, P Kuppusamy, D Lanoue, S Cho, P Korangath, M Shriver, A Begum, VF Merino, CY Huang, JL Arbiser, W Matsui, B Győrffy, K Konstantopoulos, S Sukumar, PA Marignani, NK Saxena, D Sharma |
Oncogene | 2017 |
|
Silencing of type Iγ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion
S Cao, C Chen, J Xue, Y Huang, X Yang, K Ling |
Oncology reports | 2017 |
|
Triptolide blocks the STAT3 signaling pathway through induction of protein tyrosine phosphatase SHP-1 in multiple myeloma cells
JH Kim, B Park |
International journal of molecular medicine | 2017 |
|
Role of Transcription Factors in Gastrointestinal Malignancies
GP Nagaraju, PV Bramhachari |
2017 | |
|
SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer
Z Zhou, M Wang, J Li, M Xiao, YE Chin, J Cheng, ET Yeh, J Yang, J Yi |
Oncogene | 2016 |
|
Antiproliferative Effect of Indole Phytoalexins
M Chripkova, F Zigo, J Mojzis |
Molecules (Basel, Switzerland) | 2016 |
|
MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma
HY Peng, YC Cheng, YM Hsu, GH Wu, CC Kuo, JP Liou, JY Chang, SL Jin, SG Shiah, JW Lee |
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|
The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations
JL Geiger, JR Grandis, JE Bauman |
Oral Oncology | 2016 |
|
IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma
HY Peng, SS Jiang, JR Hsiao, M Hsiao, YM Hsu, GH Wu, WM Chang, JY Chang, SL Jin, SG Shiah |
Molecular Oncology | 2016 |
|
Role of STAT3 in Genesis and Progression of Human Malignant Gliomas
ZG Ouédraogo, J Biau, JL Kemeny, L Morel, P Verrelle, E Chautard |
Molecular Neurobiology | 2016 |
|
Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression
Y Pan, S Wang, B Su, F Zhou, R Zhang, T Xu, R Zhang, V Leventaki, E Drakos, W Liu, FX Claret |
Oncogene | 2016 |
|
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AD Pra, JA Locke, G Borst, S Supiot, RG Bristow |
Frontiers in Oncology | 2016 |
|
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AC Ward |
STAT Inhibitors in Cancer | 2016 |
|
KIAA0247 suppresses the proliferation, angiogenesis and promote apoptosis of human glioma through inactivation of the AKT and Stat3 signaling pathway
Y Tan, N Huang, X Zhang, J Hu, S Cheng, L Pi, Y Cheng |
Oncotarget | 2016 |
|
IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma
HY Peng, SS Jiang, JR Hsiao, M Hsiao, YM Hsu, GH Wu, WM Chang, JY Chang, SL Jin, SG Shiah |
Molecular Oncology | 2016 |
|
Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer
M Santoni, F Massari, MD Re, C Ciccarese, F Piva, G Principato, R Montironi, D Santini, R Danesi, G Tortora, S Cascinu |
Expert Opinion on Investigational Drugs | 2015 |
|
Targeting JAK kinase in solid tumors: emerging opportunities and challenges
M Buchert, CJ Burns, M Ernst |
Oncogene | 2015 |
|
Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer
KM Lewis, U Bharadwaj, TK Eckols, M Kolosov, MM Kasembeli, C Fridley, R Siller, DJ Tweardy |
Lung Cancer | 2015 |
|
Role of STAT3 pathway in genitourinary tumors
M Santoni, A Conti, F Piva, F Massari, C Ciccarese, L Burattini, L Cheng, A Lopez-Beltran, M Scarpelli, D Santini, G Tortora, S Cascinu, R Montironi |
Future Science OA | 2015 |
|
The role of STAT3 in tumor-mediated immune suppression
SD Ferguson, VM Srinivasan, AB Heimberger |
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|
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SE Wheeler, AM Egloff, L Wang, CD James, PS Hammerman, JR Grandis, MT Teh |
PloS one | 2015 |
|
Activation of the interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma of the parotid gland
S Andreasen, MH Therkildsen, M Grauslund, L Friis-Hansen, I Wessel, P Homøe |
APMIS | 2015 |
|
The paradoxical role of IL-10 in immunity and cancer
MH Mannino, Z Zhu, H Xiao, Q Bai, MR Wakefield, Y Fang |
Cancer Letters | 2015 |
|
Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma
ME Brown, MD Bear, TJ Rosol, C Premanandan, WC Kisseberth, CA London |
BMC veterinary research | 2015 |
|
Prognostic Significance of Serine-Phosphorylated STAT3 Expression in pT1-T2 Oral Tongue Carcinoma
E Fasanaro, C Staffieri, R Cappellesso, F Marino, G Ottaviano, M Val, L Giacomelli, C Filippis, E Stellini, A Staffieri, G Marioni |
Clinical and Experimental Otorhinolaryngology | 2015 |
|
Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition
JA Bonner, HQ Trummell, AB Bonner, CD Willey, M Bredel, ES Yang |
BMC Cancer | 2015 |
|
Advances in the Chemopreventive Targeting of Oral Carcinogenesis
DJ Wisniewski, T Ma, A Schneider |
Current Oral Health Reports | 2015 |
|
Role of STAT3 pathway in genitourinary tumors
M Santoni, A Conti, F Piva, F Massari, C Ciccarese, L Burattini, L Cheng, A Lopez-Beltran, M Scarpelli, D Santini, G Tortora, S Cascinu, R Montironi |
Future Science OA | 2015 |
|
STATs: An Old Story, Yet Mesmerizing
Saeid Abroun, Najmaldin Saki, Mohammad Ahmadvand, Farahnaz Asghari, Fatemeh Salari, Fakher Rahim |
Cell Journal (Yakhteh) | 2015 |
|
Quinolone-indolone conjugate induces apoptosis by inhibiting the EGFR-STAT3-HK2 pathway in human cancer cells
YH Liu, XL Wei, GQ Hu, TX Wang |
Molecular medicine reports | 2015 |
|
The Multifaceted Role of Curcumin in Cancer Prevention and Treatment
M Shanmugam, G Rane, M Kanchi, F Arfuso, A Chinnathambi, M Zayed, S Alharbi, B Tan, A Kumar, G Sethi |
Molecules (Basel, Switzerland) | 2015 |
|
Genetic Interactions of STAT3 and Anticancer Drug Development
B Fang |
Cancers | 2014 |
|
Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention
A Xiong, Z Yang, Y Shen, J Zhou, Q Shen |
Cancers | 2014 |
|
Signal transducer and activators of transcription 3 regulates cryptotanshinone-induced apoptosis in human mucoepidermoid carcinoma cells
SD Cho, HJ Yu, C Park, SJ Kim, NP Cho |
Pharmacognosy magazine | 2014 |
|
Knockdown of PKCε Expression Inhibits Growth, Induces Apoptosis and Decreases Invasiveness of Human Glioma Cells Partially Through Stat3
Y Xu, Z Li, C Zhang, S Zhang, Y Ji, F Chen |
Journal of Molecular Neuroscience | 2014 |
|
The alpha subunit of Go modulates cell proliferation and differentiation through interactions with Necdin
H Ju, S Lee, S Kang, SS Kim, S Ghil |
Cell Communication and Signaling | 2014 |
|
Honokiol inhibits epithelial–mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis
DB Avtanski, A Nagalingam, MY Bonner, JL Arbiser, NK Saxena, D Sharma |
Molecular Oncology | 2014 |
|
An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer
ML Gatza, GO Silva, JS Parker, C Fan, CM Perou |
Nature Genetics | 2014 |
|
Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF- : Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
NS Nagathihalli, Y Beesetty, W Lee, MK Washington, X Chen, AC Lockhart, NB Merchant |
Cancer research | 2014 |
|
Immune biomarkers of anti-EGFR monoclonal antibody therapy
S Trivedi, F Concha-Benavente, RM Srivastava, HB Jie, SP Gibson, NC Schmitt, RL Ferris |
Annals of Oncology | 2014 |
|
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer
U Bharadwaj, TK Eckols, M Kolosov, MM Kasembeli, A Adam, D Torres, X Zhang, LE Dobrolecki, W Wei, MT Lewis, B Dave, JC Chang, MD Landis, CJ Creighton, MA Mancini, DJ Tweardy |
Oncogene | 2014 |
|
Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer
W Choi, B Czerniak, A Ochoa, X Su, A Siefker-Radtke, C Dinney, DJ McConkey |
Nature Reviews Urology | 2014 |
|
Use of next generation sequencing in head and neck squamous cell carcinomas: A review
S Tabatabaeifar, TA Kruse, M Thomassen, MJ Larsen, JA Sørensen |
Oral Oncology | 2014 |
|
Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects
M Mutoh, M Takahashi, K Wakabayashi |
Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects | 2014 |
|
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
KS Siveen, S Sikka, R Surana, X Dai, J Zhang, AP Kumar, BK Tan, G Sethi, A Bishayee |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 |
|
Leptin and IL-6 Family Cytokines Synergize to Stimulate Müller Glia Reprogramming and Retina Regeneration
XF Zhao, J Wan, C Powell, R Ramachandran, MG Myers, D Goldman |
Cell Reports | 2014 |
|
STAT transcription factors in normal and cancer stem cells
KA Dorritie, RL Redner, DE Johnson |
Advances in Biological Regulation | 2014 |
|
Uncovering the pathogenesis of large granular lymphocytic leukemia—novel STAT3 and STAT5b mutations
HL Rajala, K Porkka, JP Maciejewski, TP Loughran, S Mustjoki |
Annals of Medicine | 2014 |
|
Overexpression of BST2 is associated with nodal metastasis and poorer prognosis in oral cavity cancer: BST2 Overexpression in OSCC
KH Fang, HK Kao, LM Chi, Y Liang, SC Liu, C Hseuh, CT Liao, TC Yen, JS Yu, KP Chang |
The Laryngoscope | 2014 |
|
EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules
MI Ellina, P Bouris, AJ Aletras, AD Theocharis, D Kletsas, NK Karamanos |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2014 |
|
Epidermal Growth Factor Receptor (EGFR) Signaling Is a Key Mediator of Hormone-Induced Leukocyte Infiltration in the Pubertal Female Mammary Gland
MD Aupperlee, Y Zhao, YS Tan, JR Leipprandt, J Bennett, SZ Haslam, RC Schwartz |
Endocrinology | 2014 |
|
Dual high expression of STAT3 and cyclinD1 is associated with poor prognosis after curative resection of esophageal squamous cell carcinoma
Haiying Li, Weiwei Xiao, Jiwei Ma, Yong Zhang, Ru Li, Jiecheng Ye, Xiao Wang, Xueyun Zhong, Shaoxiang Wang |
International journal of clinical and experimental pathology | 2014 |
|
STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo
X Zhou, YU REN, A Liu, L Han, K Zhang, S Li, P Li, P Li, C Kang, X Wang, L Zhang |
Oncology reports | 2014 |
|
Critical analysis of the potential for targeting STAT3 in human malignancy
ND Peyser, JR Grandis |
OncoTargets and therapy | 2013 |
|
Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity
JS Ross, W Hu, B Rosen, AJ Snider, LM Obeid, LA Cowart |
The Journal of biological chemistry | 2013 |
|
Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
SY Kim, JW Kang, X Song, BK Kim, YD Yoo, YT Kwon, YJ Lee |
Cellular Signalling | 2013 |
|
Propagation of human prostate cancer stem-like cells occurs through EGFR-mediated ERK activation
AP Rybak, AJ Ingram, D Tang |
PloS one | 2013 |
|
Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3-dependent manner
Y Hu, H Chen, C Duan, D Liu, L Qian, Z Yang, L Guo, L Song, M Yu, M Hu, M Shi, N Guo |
Oncogenesis | 2013 |
|
Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma
A Subramaniam, MK Shanmugam, E Perumal, F Li, A Nachiyappan, X Dai, SN Swamy, KS Ahn, AP Kumar, BK Tan, KM Hui, G Sethi |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2013 |
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Derlin-1 Is Overexpressed in Non-Small Cell Lung Cancer and Promotes Cancer Cell Invasion via EGFR-ERK–Mediated Up-Regulation of MMP-2 and MMP-9
Q Dong, Y Wang, Z Tang, L Fu, Q Li, E Wang, EH Wang |
The American Journal of Pathology | 2013 |
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Immunotherapy for head and neck cancer patients: shifting the balance
AW Turksma, BJ Braakhuis, E Bloemena, CJ Meijer, CR Leemans, E Hooijberg |
Immunotherapy | 2013 |
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Head and neck cancer: from anatomy to biology: Biology of head and neck cancer
P Bose, NT Brockton, JC Dort |
International Journal of Cancer | 2013 |
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Cardiac hormones for the treatment of cancer
DL Vesely |
Endocrine Related Cancer | 2013 |
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Molecular underpinning of extranodal NK/T-cell lymphoma
Y Huang, L Leval, P Gaulard |
Best Practice & Research Clinical Haematology | 2013 |
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The role of Stat3 in glioblastoma multiforme
RB Luwor, SS Stylli, AH Kaye |
Journal of Clinical Neuroscience | 2013 |
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SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma
F Ren, F Su, H Ning, Y Wang, Y Geng, Y Feng, Y Wang, Y Zhang, Z Jin, Y Li, B Jia, Z Chang |
Cellular Signalling | 2013 |
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Calnexin Controls the STAT3-Mediated Transcriptional Response to EGF
AK Lakkaraju, FG van der Goot |
Molecular Cell | 2013 |
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2,2'-diphenyl-3,3'-diindolylmethane: a potent compound induces apoptosis in breast cancer cells by inhibiting EGFR pathway
A Bhowmik, N Das, U Pal, M Mandal, S Bhattacharya, M Sarkar, P Jaisankar, NC Maiti, MK Ghosh |
PloS one | 2013 |
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Voting-based cancer module identification by combining topological and data-driven properties
AK Azad, H Lee |
PloS one | 2013 |
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Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers
VW Lui, ML Hedberg, H Li, BS Vangara, K Pendleton, Y Zeng, Y Lu, Q Zhang, Y Du, BR Gilbert, M Freilino, S Sauerwein, ND Peyser, D Xiao, B Diergaarde, L Wang, S Chiosea, R Seethala, JT Johnson, S Kim, U Duvvuri, RL Ferris, M Romkes, T Nukui, PK Ng, LA Garraway, PS Hammerman, GB Mills, JR Grandis |
Cancer Discovery | 2013 |
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EGFR-mediated tumor immunoescape
F Concha-Benavente, RM Srivastava, S Ferrone, RL Ferris |
OncoImmunology | 2013 |
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Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor
TM Becker, SC Boyd, B Mijatov, K Gowrishankar, S Snoyman, GM Pupo, RA Scolyer, GJ Mann, RF Kefford, XD Zhang, H Rizos |
Oncogene | 2013 |
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Expression of EGFR and HPV-associated p16 in oropharyngeal carcinoma: Correlation and influence on prognosis after radiotherapy in the randomized DAHANCA 5 and 7 trials
P Lassen, J Overgaard, JG Eriksen |
Radiotherapy and Oncology | 2013 |
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Voting-Based Cancer Module Identification by Combining Topological and Data-Driven Properties
AK Azad, H Lee, D Zhu |
PloS one | 2013 |
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STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2
Adetola Shodeinde, Kalyani Ginjupalli, H. Dan Lewis, Sheraz Riaz, Beverly E. Barton |
Journal of molecular biochemistry | 2013 |
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Propagation of Human Prostate Cancer Stem-Like Cells Occurs through EGFR-Mediated ERK Activation
AP Rybak, AJ Ingram, D Tang, DG Tang |
PloS one | 2013 |
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2,2′-Diphenyl-3,3′-Diindolylmethane: A Potent Compound Induces Apoptosis in Breast Cancer Cells by Inhibiting EGFR Pathway
A Bhowmik, N Das, U Pal, M Mandal, S Bhattacharya, M Sarkar, P Jaisankar, NC Maiti, MK Ghosh, PC Trackman |
PloS one | 2013 |
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Experimental and Clinical Metastasis
JV Burnier, MN Burnier |
2013 | |
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Could Signal Transducer and Activator of Transcription 3 be a Therapeutic Target in Obesity-Related Gastrointestinal Malignancy?
KE OSullivan, JV Reynolds, C OHanlon, JN OSullivan, J Lysaght |
Journal of Gastrointestinal Cancer | 2013 |
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The Ubiquitin Specific Protease USP2a Prevents Endocytosis-Mediated EGFR Degradation
Z Liu, SM Zanata, J Kim, MA Peterson, DD Vizio, LR Chirieac, S Pyne, M Agostini, MR Freeman, M Loda |
Oncogene | 2012 |
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Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment
AV Lucs, B Saltman, CH Chung, BM Steinberg, DL Schwartz, JN Myers |
Head & Neck | 2012 |
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Emerging strategies for the early detection and prevention of head and neck squamous cell cancer
S Dasgupta, R Dash, SK Das, D Sarkar, PB Fisher |
Journal of Cellular Physiology | 2012 |
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Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects
AL Shodeinde, BE Barton |
OncoTargets and therapy | 2012 |
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Cord Blood Stem Cells Inhibit Epidermal Growth Factor Receptor Translocation to Mitochondria in Glioblastoma
VR Dasari, KK Velpula, K Alapati, M Gujrati, AJ Tsung |
PloS one | 2012 |
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Potent selective inhibition of STAT 3 versus STAT 1 by cardiac hormones
ML Lane, CD Frost, JP Nguyen, WP Skelton, M Skelton, DL Vesely |
Molecular and Cellular Biochemistry | 2012 |
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Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz |
Protein Engineering for Therapeutics Part B | 2012 |
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(−)-Epigallocatechin Gallate Induces Fas/CD95-Mediated Apoptosis through Inhibiting Constitutive and IL-6-Induced JAK/STAT3 Signaling in Head and Neck Squamous Cell Carcinoma Cells
HY Lin, SC Hou, SC Chen, MC Kao, CC Yu, S Funayama, CT Ho, TD Way |
Journal of Agricultural and Food Chemistry | 2012 |
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Targeting Stat3 and Smad7 to restore TGF-β cytostatic regulation of tumor cells in vitro and in vivo
RB Luwor, B Baradaran, LE Taylor, J Iaria, TV Nheu, N Amiry, CM Hovens, B Wang, AH Kaye, HJ Zhu |
Oncogene | 2012 |
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The role of STAT3 activation in modulating the immune microenvironment of GBM
AP See, JE Han, J Phallen, Z Binder, G Gallia, F Pan, D Jinasena, C Jackson, Z Belcaid, SJ Jeong, C Gottschalk, J Zeng, J Ruzevick, S Nicholas, Y Kim, E Albesiano, DM Pardoll, M Lim |
Journal of Neuro-Oncology | 2012 |
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Molecular mechanisms of curcumin action: Gene expression
S Shishodia |
BioFactors | 2012 |
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Impact of STAT3 Phosphorylation on the Clinical Effectiveness of Anti-EGFR–Based Therapy in Patients With Metastatic Colorectal Cancer
E Dobi, F Monnien, S Kim, A Ivanaj, T N'Guyen, M Demarchi, O Adotevi, A Thierry-Vuillemin, M Jary, B Kantelip, X Pivot, Y Godet, SV Degano, C Borg |
Clinical Colorectal Cancer | 2012 |
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STAT3 as a therapeutic target for Epstein-Barr virus (EBV) – associated nasopharyngeal carcinoma
Y Ho, SW Tsao, M Zeng, VW Lui |
Cancer Letters | 2012 |
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The efficiency of silencing expression of the gene coding STAT3 transcriptional factor and susceptibility of bladder cancer cells to apoptosis
I Bednarek, D Sypniewski, N Gawlik, A Galilejczyk, K Goraus |
WSPOLCZESNA ONKOL | 2012 |
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Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer
SE Wheeler, EM Morariu, JS Bednash, CG Otte, RR Seethala, SI Chiosea, JR Grandis |
Clinical cancer research | 2012 |
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Targeting proliferation and survival pathways in head and neck cancer for therapeutic benefit
DE Johnson |
Chinese journal of cancer | 2012 |
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Targeting proliferation and survival pathways in head and neck cancer for therapeutic benefit
DE Johnson |
Chinese journal of cancer | 2012 |
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Cord Blood Stem Cells Inhibit Epidermal Growth Factor Receptor Translocation to Mitochondria in Glioblastoma
VR Dasari, KK Velpula, K Alapati, M Gujrati, AJ Tsung, AP Beltrami |
PloS one | 2012 |
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STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers
X Wang, PJ Crowe, D Goldstein, JL Yang |
International journal of oncology | 2012 |
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B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation
H Liu, C Tekle, YW Chen, A Kristian, Y Zhao, M Zhou, Z Liu, Y Ding, B Wang, GM Mælandsmo, JM Nesland, O Fodstad, M Tan |
Molecular cancer therapeutics | 2011 |
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Prognostic value of co-expression of STAT3, mTOR and EGFR in gastric cancer
M Inokuchi, T Murayama, M Hayashi, Y Takagi, K Kato, M Enjoji, K Kojima, J Kumagai, K Sugihara |
Experimental and therapeutic medicine | 2011 |
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The Role of Chalcones in Suppression of NF-κB-Mediated Inflammation and Cancer
VR Yadav, S Prasad, B Sung, BB Aggarwal |
International Immunopharmacology | 2011 |
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High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways
JA Krall, EM Beyer, G MacBeath |
PloS one | 2011 |
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STAT-Related Profiles Are Associated with Patient Response to Targeted Treatments in Locally Advanced SCCHN
V Kotoula, S Lambaki, D Televantou, A Kalogera-Fountzila, A Nikolaou, K Markou, D Misailidou, KN Syrigos, G Fountzilas |
Translational oncology | 2011 |
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Combined treatment targeting HIF-1α and Stat3 is a potent strategy for prostate cancer therapy
KR Reddy, Y Guan, G Qin, Z Zhou, N Jing |
The Prostate | 2011 |
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Non-telomeric activities of telomerase
J Majerská, E Sýkorová, J Fajkus |
Molecular BioSystems | 2011 |
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Non-small cell 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma
W Chen, X Shen, X Xia, G Xu, T Ma, X Bai, T Liang |
Liver International | 2011 |
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A Neutralizing RNA Aptamer against EGFR Causes Selective Apoptotic Cell Death
CL Esposito, D Passaro, I Longobardo, G Condorelli, P Marotta, A Affuso, V Franciscis, L Cerchia |
PloS one | 2011 |
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Necdin, a Negative Growth Regulator, Is a Novel STAT3 Target Gene Down-Regulated in Human Cancer
R Haviland, S Eschrich, G Bloom, Y Ma, S Minton, R Jove, WD Cress |
PloS one | 2011 |
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Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor
MS Redell, MJ Ruiz, TA Alonzo, RB Gerbing, DJ Tweardy |
Blood | 2011 |
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The antagonistic effect between STAT1 and Survivin and its clinical significance in gastric cancer
H Deng, H Zhen, Z Fu, X Huang, H Zhou, L Liu |
Oncology Letters | 2011 |
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Molecular parameters of head and neck cancer metastasis
SL Bhave, TN Teknos, Q Pan |
Critical reviews in eukaryotic gene expression | 2011 |
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PI3K and STAT3: a new alliance
PK Vogt, JR Hart |
Cancer Discovery | 2011 |
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Receptor-Tyrosine-Kinase-Targeted Therapies for Head and Neck Cancer
LA Elferink, VA Resto |
Journal of Signal Transduction | 2011 |
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A Neutralizing RNA Aptamer against EGFR Causes Selective Apoptotic Cell Death
CL Esposito, D Passaro, I Longobardo, G Condorelli, P Marotta, A Affuso, V Franciscis, L Cerchia, PC Yang |
PloS one | 2011 |
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Necdin, a Negative Growth Regulator, Is a Novel STAT3 Target Gene Down-Regulated in Human Cancer
R Haviland, S Eschrich, G Bloom, Y Ma, S Minton, R Jove, WD Cress, T Shioda |
PloS one | 2011 |
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High- and Low-Affinity Epidermal Growth Factor Receptor-Ligand Interactions Activate Distinct Signaling Pathways
JA Krall, EM Beyer, G MacBeath, NA Hotchin |
PloS one | 2011 |
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Prognostic value of co-expression of STAT3, mTOR and EGFR in gastric cancer
M Inokuchi, T Murayama, M Hayashi, Y Takagi, K Kato, M Enjoji, K Kojima, J Kumagai, K Sugihara |
Experimental and therapeutic medicine | 2011 |
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Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells
X Liang, EA Moseman, MA Farrar, V Bachanova, DJ Weisdorf, BR Blazar, W Chen |
Blood | 2010 |
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Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors
RJ Leeman-Neill, Q Cai, SC Joyce, SM Thomas, NE Bhola, DB Neill, JL Arbiser, JR Grandis |
Clinical cancer research | 2010 |
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The role of constitutively activated STAT3 in B16 melanoma cells
CH Yang, M Fan, AT Slominski, J Yue, LM Pfeffer |
International journal of interferon, cytokine and mediator research : IJIM | 2010 |
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Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis
O Rho, DJ Kim, K Kiguchi, J Digiovanni |
Molecular Carcinogenesis | 2010 |
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Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling
MH Lin, KW Chang, SC Lin, JH Miner |
Developmental Biology | 2010 |
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Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
SE Wheeler, S Suzuki, SM Thomas, M Sen, RJ Leeman-Neill, SI Chiosea, CT Kuan, DD Bigner, WE Gooding, SY Lai, JR Grandis |
Oncogene | 2010 |
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Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
SY Lai, FM Johnson |
Drug Resistance Updates | 2010 |
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Histopathologic findings of HPV and p16 positive HNSCC
AH Mendelsohn, CK Lai, IP Shintaku, DA Elashoff, SM Dubinett, E Abemayor, MA st. John |
The Laryngoscope | 2010 |
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The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine
A Alshamsan, S Hamdy, J Samuel, AO El-Kadi, A Lavasanifar, H Uludağ |
Biomaterials | 2010 |
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A Phase I/II Trial of Gefitinib Given Concurrently With Radiotherapy in Patients With Nonmetastatic Prostate Cancer
G Joensuu, T Joensuu, P Nokisalmi, C Reddy, J Isola, M Ruutu, M Kouri, PA Kupelian, J Collan, S Pesonen, A Hemminki |
International journal of radiation oncology, biology, physics | 2010 |
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Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts
H OHARA, S ICHIKAWA, H MATSUMOTO, M AKIYAMA, N FUJIMOTO, T KOBAYASHI, S TAJIMA |
The Journal of Dermatology | 2010 |
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Cancer Prevention With Natural Compounds
NP Gullett, AR Amin, S Bayraktar, JM Pezzuto, DM Shin, FR Khuri, BB Aggarwal, YJ Surh, O Kucuk |
Seminars in Oncology | 2010 |
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Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies
I Astsaturov, V Ratushny, A Sukhanova, MB Einarson, T Bagnyukova, Y Zhou, K Devarajan, JS Silverman, N Tikhmyanova, N Skobeleva, A Pecherskaya, RE Nasto, C Sharma, SA Jablonski, IG Serebriiskii, LM Weiner, EA Golemis |
Science signaling | 2010 |
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Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma
RJ Leeman-Neill, RR Seethala, SV Singh, ML Freilino, JS Bednash, SM Thomas, MC Panahandeh, WE Gooding, SC Joyce, MW Lingen, DB Neill, JR Grandis |
Cancer prevention research (Philadelphia, Pa.) | 2010 |
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Chemopreventive potential of natural compounds in head and neck cancer
MA Rahman, AR Amin, DM Shin |
Nutrition and Cancer | 2010 |
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Emerging drugs to treat squamous cell carcinomas of the head and neck
C Fung, JR Grandis |
Expert Opinion on Emerging Drugs | 2010 |
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Signaling Pathways in Squamous Cancer
AB Glick, CV Waes |
2010 | |
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Nuclear Localization of Signal Transducer and Activator of Transcription 3 in Head and Neck Squamous Cell Carcinoma Is Associated with a Better Prognosis
E Pectasides, AM Egloff, C Sasaki, P Kountourakis, B Burtness, G Fountzilas, U Dafni, T Zaramboukas, T Rampias, D Rimm, J Grandis, A Psyrri |
Clinical cancer research | 2010 |
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Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation
A Hosui, A Kimura, D Yamaji, B Zhu, R Na, L Hennighausen |
Journal of Experimental Medicine | 2009 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?
BB Aggarwal, AB Kunnumakkara, KB Harikumar, SR Gupta, ST Tharakan, C Koca, S Dey, B Sung |
Annals of the New York Academy of Sciences | 2009 |
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Dysregulated molecular networks in head and neck carcinogenesis
AA Molinolo, P Amornphimoltham, CH Squarize, RM Castilho, V Patel, JS Gutkind |
Oral Oncology | 2009 |
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STATs in cancer inflammation and immunity: a leading role for STAT3
H Yu, D Pardoll, R Jove |
Nature Reviews Cancer | 2009 |
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Targeting EGFR resistance networks in head and neck cancer
V Ratushny, I Astsaturov, BA Burtness, EA Golemis, JS Silverman |
Cellular Signalling | 2009 |
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Mechanisms of tumor resistance to EGFR-targeted therapies
EA Hopper-Borge, RE Nasto, V Ratushny, LM Weiner, EA Golemis, I Astsaturov |
Expert Opinion on Therapeutic Targets | 2009 |
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Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3
RJ Leeman-Neill, SE Wheeler, SV Singh, SM Thomas, RR Seethala, DB Neill, MC Panahandeh, ER Hahm, SC Joyce, M Sen, Q Cai, ML Freilino, C Li, DE Johnson, JR Grandis |
Carcinogenesis | 2009 |
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Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death
C Li, Y Zang, M Sen, RJ Leeman-Neill, DS Man, JR Grandis, DE Johnson |
Molecular cancer therapeutics | 2009 |
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Perspectives for cancer prevention with natural compounds
AR Amin, O Kucuk, FR Khuri, DM Shin |
Journal of Clinical Oncology | 2009 |
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Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms
SY Lai, P Koppikar, SM Thomas, EE Childs, AM Egloff, RR Seethala, BF Branstetter, WE Gooding, A Muthukrishnan, JM Mountz, VW Lui, DM Shin, SS Agarwala, R Johnson, LA Couture, EN Myers, JT Johnson, G Mills, A Argiris, JR Grandis |
Journal of Clinical Oncology | 2009 |
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The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate
RP Sahu, SK Srivastava |
Journal of the National Cancer Institute | 2009 |
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ErbB receptors in the biology and pathology of the aerodigestive tract
S Morgan, JR Grandis |
Experimental Cell Research | 2009 |
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Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling
KG Neiva, Z Zhang, M Miyazawa, KA Warner, E Karl, JE Nör |
Neoplasia (New York, N.Y.) | 2009 |
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STAT proteins in cancerogenesis and therapy of malignancies
G Konjevic |
Srpski arhiv za celokupno lekarstvo | 2009 |
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STAT3 activation contributes directly to Epstein-Barr virus-mediated invasiveness of nasopharyngeal cancer cellsin vitro
VW Lui, EY Wong, Y Ho, B Hong, SC Wong, Q Tao, GC Choi, TC Au, K Ho, DM Yau, BB Ma, EP Hui, AS Chan, CM Tsang, SW Tsao, JR Grandis, AT Chan |
International Journal of Cancer | 2009 |
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Expression of Signal Transducer and Activator of Transcription 3 and Suppressor of Cytokine Signaling 3 in Urothelial Carcinoma
WT Huang, SF Yang, CC Wu, WT Chen, YC Huang, YC Su, CY Chai |
The Kaohsiung Journal of Medical Sciences | 2009 |
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Intratumoral Epidermal Growth Factor Receptor Antisense DNA Therapy in Head and Neck Cancer: First Human Application and Potential Antitumor Mechanisms
SY Lai, P Koppikar, SM Thomas, EE Childs, AM Egloff, RR Seethala, BF Branstetter, WE Gooding, A Muthukrishnan, JM Mountz, VW Lui, DM Shin, SS Agarwala, R Johnson, LA Couture, EN Myers, JT Johnson, G Mills, A Argiris, JR Grandis |
Journal of Clinical Oncology | 2009 |
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Perspectives for Cancer Prevention With Natural Compounds
AR Amin, O Kucuk, FR Khuri, DM Shin |
Journal of Clinical Oncology | 2009 |
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Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation
HW Su, SW Wang, FK Ghishan, PR Kiela, MJ Tang |
American journal of physiology. Cell physiology | 2009 |
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Methods of Cancer Diagnosis, Therapy, and Prognosis
MA Hayat |
2009 | |
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STAT3 as a target for inducing apoptosis in solid and hematological tumors
KA Siddiquee, J Turkson |
Cell Research | 2008 |
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STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5′ and 3′ ends
HD Lewis, A Winter, TF Murphy, S Tripathi, VN Pandey, BE Barton |
Molecular cancer therapeutics | 2008 |
|
Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells
J Xu, R Sylvester, AP Tighe, S Chen, LJ Gudas |
Journal of Molecular Biology | 2008 |
|
Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3
U Bharadwaj, M Li, C Chen, Q Yao |
Molecular cancer research : MCR | 2008 |
|
Interleukin-6 predicts recurrence and survival among head and neck cancer patients
SA Duffy, JM Taylor, JE Terrell, M Islam, Y Li, KE Fowler, GT Wolf, TN Teknos |
Cancer | 2008 |
|
Role of curcumin in health and disease
L Pari, D Tewas, J Eckel |
Archives Of Physiology And Biochemistry | 2008 |
|
Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation
HW Su, SW Wang, FK Ghishan, PR Kiela, MJ Tang |
American journal of physiology. Cell physiology | 2008 |
|
Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer
AM Egloff, JR Grandis |
Seminars in Oncology | 2008 |
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An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis
SY Cheranov, M Karpurapu, D Wang, B Zhang, RC Venema, GN Rao |
Blood | 2008 |
|
β-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma
S Yan, C Zhou, W Zhang, G Zhang, X Zhao, S Yang, Y Wang, N Lu, H Zhu, N Xu |
Cancer Letters | 2008 |
|
STAT3: An Important Regulator of Multiple Cytokine Functions
SM Stepkowski, W Chen, JA Ross, ZS Nagy, RA Kirken |
Transplantation | 2008 |
|
Design, synthesis, and studies of small molecule STAT3 inhibitors
D Bhasin, K Cisek, T Pandharkar, N Regan, C Li, B Pandit, J Lin, PK Li |
Bioorganic & Medicinal Chemistry Letters | 2008 |
|
Structural basis for the binding of high affinity phosphopeptides to Stat3
JS McMurray |
Biopolymers | 2008 |
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Immunohistochemical Analysis of Phosphotyrosine Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor Autocrine Signaling Pathways in Head and Neck Cancers and Metastatic Lymph Nodes
RR Seethala, WE Gooding, PN Handler, B Collins, Q Zhang, JM Siegfried, JR Grandis |
Clinical cancer research | 2008 |
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Signal Transducer and Activator of Transcription 3 is required for hypoxia-inducible factor-1α RNA expression in both tumor cells and tumor-associated myeloid cells
G Niu, J Briggs, J Deng, Y Ma, H Lee, M Kortylewski, M Kujawski, H Kay, WD Cress, R Jove, H Yu |
Molecular cancer research : MCR | 2008 |
|
Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy
S Choi, JN Myers |
Journal of dental research | 2008 |
|
EGFR Signaling Networks in Cancer Therapy
JD Haley, WJ Gullick |
2008 | |
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Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators
HW Lo, X Cao, H Zhu, F Ali-Osman |
Clinical cancer research | 2008 |
|
The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
BB Aggarwal, YJ Surh, S Shishodia |
2007 | |
|
The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
BB Aggarwal, YJ Surh, S Shishodia |
2007 | |
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The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
BB Aggarwal, YJ Surh, S Shishodia |
2007 | |
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The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
BB Aggarwal, YJ Surh, S Shishodia |
2007 | |
|
The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
BB Aggarwal, YJ Surh, S Shishodia |
2007 | |
|
The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
BB Aggarwal, YJ Surh, S Shishodia |
2007 | |
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The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
BB Aggarwal, YJ Surh, S Shishodia |
2007 | |
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Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting Signal Transducer and Activator of Transcription (STAT) 3: The Role of STAT1
VW Lui, AL Boehm, P Koppikar, RJ Leeman, D Johnson, M Ogagan, E Childs, M Freilino, JR Grandis |
Molecular pharmacology | 2007 |
|
Role of Curcumin in Cancer Therapy
S Shishodia, MM Chaturvedi, BB Aggarwal |
Current Problems in Cancer | 2007 |
|
Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
NK Saxena, D Sharma, X Ding, S Lin, F Marra, D Merlin, FA Anania |
Cancer research | 2007 |
|
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3
NK Saxena, PM Vertino, FA Anania, D Sharma |
The Journal of biological chemistry | 2007 |
|
Computational study on mechanism of G-quartet oligonucleotide T40214 selectively targeting Stat3
Q Zhu, N Jing |
Journal of Computer-Aided Molecular Design | 2007 |
|
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
H Yu, M Kortylewski, D Pardoll |
Nature Reviews Immunology | 2007 |
|
EGF-induced apoptosis in A431 cells is dependent on STAT1, but not on STAT3
PS Grudinkin, VV Zenin, AV Kropotov, VN Dorosh, NN Nikolsky |
European Journal of Cell Biology | 2007 |
|
PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor
LE Roberts, MA Fini, N Derkash, RM Wright |
Journal of Cellular Biochemistry | 2007 |
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Solid Phase Synthesis of Phosphopeptides Incorporating 2,2-Dimethyloxazolidine Pseudoproline Analogs: Evidence for trans Leu-Pro Peptide Bonds in Stat3 Inhibitors
DR Coleman, K Kaluarachchi, Z Ren, X Chen, JS McMurray |
International Journal of Peptide Research and Therapeutics | 2007 |
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Cell Confluence-induced Activation of Signal Transducer and Activator of Transcription-3 (Stat3) Triggers Epithelial Dome Formation via Augmentation of Sodium Hydrogen Exchanger-3 (NHE3) Expression
HW Su, HH Yeh, SW Wang, MR Shen, TL Chen, PR Kiela, FK Ghishan, MJ Tang |
The Journal of biological chemistry | 2007 |
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Leptin-induced Growth Stimulation of Breast Cancer Cells Involves Recruitment of Histone Acetyltransferases and Mediator Complex to CYCLIN D1 Promoter via Activation of Stat3
NK Saxena, PM Vertino, FA Anania, D Sharma |
The Journal of biological chemistry | 2007 |
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Apoptosis, Senescence, and Cancer
DA Gewirtz, SE Holt, S Grant |
2007 | |
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Downregulation of STAT1 by Promoter Methylation is Critical for Squamous Cell Carcinogenesis
Sichuan Xi, Kevin F. Dyer, Mark Kimak, Qing Zhang, William E. Gooding, J. Richard ChailleT, Raymond Liu Chai, Robert E. Ferrel, Beth Zamboni, Jennifer Hunt, Jennifer Rubin Grandis |
JNCI Journal of the National Cancer Institute | 2006 |
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Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions
W Yin, S Cheepala, JN Roberts, K Syson-Chan, J DiGiovanni, JL Clifford |
Molecular Cancer | 2006 |
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Unique Structural Determinants for Stat3 Recruitment and Activation by the Granulocyte Colony-Stimulating Factor Receptor at Phosphotyrosine Ligands 704 and 744
H Shao, X Xu, N Jing, DJ Tweardy |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
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A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor
ZS Nagy, H Rui, SM Stepkowski, J Karras, RA Kirken |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Modern Nutrition Science
C Cooper, E Tredget, C Watters |
Nutrition and Wound Healing | 2006 |
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Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways
D Sharma, NK Saxena, PM Vertino, FA Anania |
Endocrine Related Cancer | 2006 |
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STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines
W Zhou, JR Grandis, A Wells |
British Journal of Cancer | 2006 |
|
Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma
CH Squarize, RM Castilho, V Sriuranpong, DS Pinto, JS Gutkind |
Neoplasia (New York, N.Y.) | 2006 |
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Overexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation
Y Ogata, T Osaki, T Naka, K Iwahori, M Furukawa, I Nagatomo, T Kijima, T Kumagai, M Yoshida, I Tachibana, I Kawase |
Neoplasia (New York, N.Y.) | 2006 |
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Expression of Stat3 in Feline Mammary Gland Tumours and its Relation to Histological Grade
C Petterino, A Ratto, E Arcicasa, G Podestà, M Drigo, C Pellegrino |
Veterinary Research Communications | 2006 |
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Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane)
N Chakravarti, JN Myers, BB Aggarwal |
International Journal of Cancer | 2006 |
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Targeting Signal-Transducer-and-Activator-of-Transcription-3 for Prevention and Therapy of Cancer
BB Aggarwal, G Sethi, KS Ahn, SK Sandur, MK Pandey, AB Kunnumakkara, B Sung, H Ichikawa |
Annals of the New York Academy of Sciences | 2006 |
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STAT3 as a therapeutic target in head and neck cancer
RJ Leeman, VW Lui, JR Grandis |
Expert Opinion on Biological Therapy | 2006 |
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Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats
XT Yu, SN Zhu, ZD Xu, XQ Hu, TF Zhu, JQ Chen, SL Lu |
Journal of Cancer Research and Clinical Oncology | 2006 |
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Restoration of shp1 expression by 5-AZA-2′-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma
Y Han, HM Amin, C Frantz, B Franko, J Lee, Q Lin, R Lai |
Leukemia | 2006 |
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Expression of phosphorylated Stat3, cyclin D1 and Bcl-xL in extramammary Paget disease
HJ Liu, Y Moroi, T Masuda, S Yasumoto, H Kokuba, S Imafuku, T Koga, T Tetsuya, YT Tu, H Aburatani, M Furue, K Urabe |
British Journal of Dermatology | 2006 |
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Knockdown of Stat3 expression using RNAi inhibits growth of laryngeal tumors in vivo
L GAO, L Wen, H YU, L ZHANG, Y MENG, Y SHAO, D XU, X ZHAO |
Acta Pharmacologica Sinica | 2006 |
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Effect of STAT3 siRNA-induced inhibition of STAT3 gene expression on the growth and apoptosis of lewis lung cancer cells
C Wang, M Sun, X Zhao, X Zhang |
Chinese Journal of Clinical Oncology | 2006 |
|
Methylation of Stat1 Promoter Can Contribute to Squamous Cell Carcinogenesis
H Lee, H Yu |
JNCI Journal of the National Cancer Institute | 2006 |
|
Novel Anticancer Agents
MM Ameyaw, HL Mcleod |
Novel Anticancer Agents | 2006 |
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Molecular Cross-Talk between the NFκB and STAT3 Signaling Pathways in Head and Neck Squamous Cell Carcinoma
CH Squarize, RM Castilho, V Sriuranpong, DS Pinto, JS Gutkind |
Neoplasia (New York, N.Y.) | 2006 |
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Overexpression of PIAS3 Suppresses Cell Growth, Restores the Drug Sensitivity of Human Lung Cancer Cells in Association with PI3-K/Akt Inactivation
Y Ogata, T Osaki, T Naka, K Iwahori, M Furukawa, I Nagatomo, T Kijima, T Kumagai, M Yoshida, I Tachibana, I Kawase |
Neoplasia (New York, N.Y.) | 2006 |
|
Molecular Biology of Oral Cavity Squamous Cell Carcinoma
ME Kupferman, JN Myers |
Otolaryngologic Clinics of North America | 2006 |
|
Immunodetection of the signal transducer and activator of transcription-3 in canine haemangioma and haemangiosarcoma
C Petterino, E Rossetti, M Drigo |
Research in Veterinary Science | 2006 |
|
Molecular targets of dietary agents for prevention and therapy of cancer
BB Aggarwal, S Shishodia |
Biochemical Pharmacology | 2006 |
|
Epidermal Growth Factor Receptor Biology in Head and Neck Cancer
S Kalyankrishna, JR Grandis |
Journal of Clinical Oncology | 2006 |
|
Cell Motility in Cancer Invasion and Metastasis
A Wells |
2006 | |
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Identification of Cellular Intermediates and Molecular Pathways Induced by IL-21 in Human B Cells
D Konforte, CJ Paige |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
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Phosphorylation of STAT3 Serine-727 by Cyclin-Dependent Kinase 1 Is Critical for Nocodazole-Induced Mitotic Arrest
X Shi, H Zhang, H Paddon, G Lee, X Cao, S Pelech |
Biochemistry | 2006 |
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Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
Y Han, HM Amin, B Franko, C Frantz, X Shi, R Lai |
Blood | 2006 |
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Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats
XT Yu, SN Zhu, ZD Xu, , TF Zhu, JQ Chen, SL Lu |
Journal of Cancer Research and Clinical Oncology | 2006 |
|
Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma
SY Lai, EE Childs, S Xi, FM Coppelli, WE Gooding, A Wells, RL Ferris, JR Grandis |
Oncogene | 2005 |
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Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells
HF Huang, TF Murphy, P Shu, AB Barton, BE Barton |
Molecular Cancer | 2005 |
|
Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor
Coleman, Z Ren, PK Mandal, AG Cameron, GA Dyer, S Muranjan, M Campbell, X Chen, JS McMurray |
Journal of Medicinal Chemistry | 2005 |
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MET meet adaptors: Functional and structural implications in downstream signalling mediated by the Met receptor
VM Bolanos-Garcia |
Molecular and Cellular Biochemistry | 2005 |
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Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth
FM Corvinus, C Orth, R Moriggl, SA Tsareva, S Wagner, EB Pfitzner, D Baus, R Kaufmann, LA Huber, K Zatloukal, H Beug, P Ohlschläger, A Schütz, KJ Halbhuber, K Friedrich |
Neoplasia (New York, N.Y.) | 2005 |
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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
Q Xu, J Briggs, S Park, G Niu, M Kortylewski, S Zhang, T Gritsko, J Turkson, H Kay, GL Semenza, JQ Cheng, R Jove, H Yu |
Oncogene | 2005 |
|
Targeting STAT3 affects melanoma on multiple fronts
M Kortylewski, R Jove, H Yu |
Cancer and Metastasis Reviews | 2005 |
|
Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells
L GAO, D XU, L WEN, X ZHANG, Y SHAO, X ZHAO |
Acta Pharmacologica Sinica | 2005 |
|
Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells
M Itoh, T Murata, T Suzuki, M Shindoh, K Nakajima, K Imai, K Yoshida |
Oncogene | 2005 |
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Analysis of the epidermal growth factor receptor specific transcriptome: Effect of receptor expression level and an activating mutation
MW Pedersen, N Pedersen, L Damstrup, M Villingshøj, SU Sønder, K Rieneck, LF Bovin, M Spang-Thomsen, HS Poulsen |
Journal of Cellular Biochemistry | 2005 |
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The role of p-STAT3 (ser727) revealed by its association with Ki-67 in cervical intraepithelial neoplasia
SF Yang, SS Yuan, YT Yeh, MT Wu, JH Su, SC Hung, CY Chai |
Gynecologic Oncology | 2005 |
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The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study
JG Eriksen, T Steiniche, J Overgaard |
Radiotherapy and Oncology | 2005 |
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The Human Hyaluronan Synthase 2 Gene Is a Primary Retinoic Acid and Epidermal Growth Factor Responding Gene
K Saavalainen, S Pasonen-Seppänen, TW Dunlop, R Tammi, MI Tammi, C Carlberg |
The Journal of biological chemistry | 2005 |
|
Biological significance of c-erbB family oncogenes in head and neck cancer
SJ Rogers, KJ Harrington, P Rhys-Evans, P O-Charoenrat, SA Eccles |
Cancer and Metastasis Reviews | 2005 |
|
Disruption of Stat3 reveals a critical role in both the initiation and promotion stages of epithelial carcinogenesis
Keith Syson Chan, Shigetoshi Sano, Kaoru Kiguchi, Joanne Anders, Nobuyasu Komazawa, Junji Takeda, John DiGiovanni |
Journal of Clinical Investigation | 2004 |
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EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes
CD Andl, T Mizushima, K Oyama, M Bowser, H Nakagawa, AK Rustgi |
AJP Gastrointestinal and Liver Physiology | 2004 |
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Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells
H Siavash, NG Nikitakis, JJ Sauk |
British Journal of Cancer | 2004 |
|
Novel therapeutic targets in squamous cell carcinoma of the head and neck
EE Cohen |
Seminars in Oncology | 2004 |
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Prevention of head and neck cancer: Current status and future prospects
S Jain, FR Khuri, DM Shin |
Current Problems in Cancer | 2004 |
|
The STATs of cancer — new molecular targets come of age
H Yu, R Jove |
Nature Reviews Cancer | 2004 |
|
STAT proteins as novel targets for cancer drug discovery
J Turkson |
Expert Opinion on Therapeutic Targets | 2004 |
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Interleukin-6 Induced Basic Fibroblast Growth Factor-Dependent Angiogenesis in Basal Cell Carcinoma Cell Line via JAK/STAT3 and PI3-Kinase/Akt Pathways
SH Jee, CY Chu, HC Chiu, YL Huang, WL Tsai, YH Liao, ML Kuo |
Journal of Investigative Dermatology | 2004 |
|
Signaling through the epidermal growth factor receptor during the development of malignancy
JR Grandis, JC Sok |
Pharmacology & Therapeutics | 2004 |
|
Aberrant expression of interleukin-7 (IL-7) and its signalling complex in human breast cancer
MA Al-Rawi, K Rmali, G Watkins, RE Mansel, WG Jiang |
European Journal of Cancer | 2004 |
|
Adenoviral vector–mediated augmentation of epidermal growth factor receptor (EGFr) enhances the radiosensitization properties of anti-EGFr treatment in prostate cancer cells
JA Bonner, DJ Buchsbaum, BE Rogers, WE Grizzle, HQ Trummell, DT Curiel, JB Fiveash, R Ove, KP Raisch |
International journal of radiation oncology, biology, physics | 2004 |
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S ignal T ransducers and A ctivators of T ranscription: I nsights into the M olecular B asis of O ral C ancer
H Siavash, NG Nikitakis, JJ Sauk |
Critical Reviews in Oral Biology & Medicine | 2004 |
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Structural Requirements for Signal Transducer and Activator of Transcription 3 Binding to Phosphotyrosine Ligands Containing the Y XX Q Motif
H Shao, X Xu, MA Mastrangelo, N Jing, RG Cook, GB Legge, DJ Tweardy |
The Journal of biological chemistry | 2004 |
|
Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell–cell adhesion complexes
C Rivat, OD Wever, E Bruyneel, M Mareel, C Gespach, S Attoub |
Oncogene | 2004 |
|
Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma
HM Amin, TJ McDonnell, Y Ma, Q Lin, Y Fujio, K Kunisada, V Leventaki, P Das, GZ Rassidakis, C Cutler, LJ Medeiros, R Lai |
Oncogene | 2004 |
|
Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA
K Paz, ND Socci, E Nimwegen, A Viale, JE Darnell |
Oncogene | 2004 |
|
Signal Transduction in Cancer
DA Frank |
2004 | |
|
Hematopoietic Growth Factors in Oncology
G Morstyn, MA Foote, GJ Lieschke |
2004 | |
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Effects of Acyclic Retinoid on Growth, Cell Cycle Control, Epidermal Growth Factor Receptor Signaling, and Gene Expression in Human Squamous Cell Carcinoma Cells
M Shimizu, M Suzui, A Deguchi, JT Lim, IB Weinstein |
Clinical cancer research | 2004 |
|
Epidermal Growth Factor Receptor-Mediated Activation of Stat3 during Multistage Skin Carcinogenesis
KS Chan, S Carbajal, K Kiguchi, J Clifford, S Sano, J DiGiovanni |
Cancer research | 2004 |
|
VEGF differentially activates STAT3 in microvascular endothelial cells
M Bartoli, DH Platt, T Lemtalsi, X Gu, SE Brooks, MB Marrero, RB Caldwell |
The FASEB Journal | 2003 |
|
STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling
CM Ulane, JJ Rodriguez, JP Parisien, CM Horvath |
Journal of virology | 2003 |
|
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth
PL Leong, GA Andrews, DE Johnson, KF Dyer, S Xi, JC Mai, PD Robbins, S Gadiparthi, NA Burke, SF Watkins, JR Grandis |
Proceedings of the National Academy of Sciences | 2003 |
|
Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium
R Wu, S Sun, BM Steinberg |
Molecular Medicine | 2003 |
|
Keratinocyte Growth Inhibition by High-Dose Epidermal Growth Factor Is Mediated by Transforming Growth Factor β Autoinduction: A Negative Feedback Mechanism for Keratinocyte Growth
K Yamasaki, N Toriu, Y Hanakawa, Y Shirakata, K Sayama, A Takayanagi, M Ohtsubo, S Gamou, N Shimizu, M Fujii, K Miyazono, K Hashimoto |
Journal of Investigative Dermatology | 2003 |
|
Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer
A Scholz, S Heinze, KM Detjen, M Peters, M Welzel, P Hauff, M Schirner, B Wiedenmann, S Rosewicz |
Gastroenterology | 2003 |
|
STAT proteins mediate angiotensin II-induced production of TIMP-1 in human proximal tubular epithelial cells
X Chen, J Wang, F Zhou, X Wang, Z Feng |
Kidney International | 2003 |
|
Differentiation-dependent expression of signal transducers and activators of transcription (STATs) might modify responses to growth factors in the cancers of the head and neck
I Arany, SH Chen, JK Megyesi, K Adler-Storthz, Z Chen, S Rajaraman, IA Ember, SK Tyring, MM Brysk |
Cancer Letters | 2003 |
|
Effect of calmodulin and voltage-dependent Ca2+ channel on the proliferation of heptoma cells induced by epidermal growth factor
W Binwen, W Jialong, Y Shunyu, C Wuren |
Journal of Huazhong University of Science and Technology [Medical Sciences] | 2003 |
|
STAT proteins: From normal control of cellular events to tumorigenesis
V Cal�, M Migliavacca, V Bazan, M Macaluso, M Buscemi, N Gebbia, A Russo |
Journal of Cellular Physiology | 2003 |
|
The EGF Receptor Family
RN Jorissen, F Walker, N Pouliot, TP Garrett, CW Ward, AW Burgess |
The EGF Receptor Family | 2003 |
|
Signal transducer and activator of transcription proteins in leukemias
M Benekli, MR Baer, H Baumann, M Wetzler |
Blood | 2003 |
|
Cross-talk Between Retinoic Acid and STAT3 Signaling Pathways in Acute Promyelocytic Leukemia
S Dong, SJ Chen, DJ Tweardy |
Leukemia & Lymphoma | 2003 |
|
S100B-RAGE-mediated augmentation of angiotensin II-induced activation of JAK2 in vascular smooth muscle cells is dependent on PLD2
Sean S Shaw, Ann Marie Schmidt, Amy K Banes, Xiaodan Wang, David M Stern, Mario B Marrero |
Diabetes | 2003 |
|
Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells
BW Wu |
World journal of gastroenterology : WJG | 2003 |
|
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
D Wei, X Le, L Zheng, L Wang, JA Frey, AC Gao, Z Peng, S Huang, HQ Xiong, JL Abbruzzese, K Xie |
Oncogene | 2003 |
|
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
L Song, J Turkson, JG Karras, R Jove, EB Haura |
Oncogene | 2003 |
|
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines
D DeArmond, MG Brattain, JM Jessup, J Kreisberg, S Malik, S Zhao, JW Freeman |
Oncogene | 2003 |
|
Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2
RA Steinman, A Wentzel, Y Lu, C Stehle, JR Grandis |
Oncogene | 2003 |
|
In vivo cooperation between Bcl-x L and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis
J Umeda, S Sano, K Kogawa, N Motoyama, K Yoshikawa, S Itami, Kondoh, T Watanabe, J Takeda |
The FASEB Journal | 2003 |
|
Signal Transducers and Activators of Transcription (STATs)
PB Sehgal, DE Levy, T Hirano |
2003 | |
|
Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells.
Wu BW, Wu Y, Wang JL, Lin JS, Yuan SY, Li A, Cui WR |
World Journal of Gastroenterology | 2003 |
|
Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis
FR Greten, CK Weber, TF Greten, G Schneider, M Wagner, G Adler, RM Schmid |
Gastroenterology | 2002 |
|
STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P
A Horiguchi, M Oya, K Marumo, M Murai |
Kidney International | 2002 |
|
Retinoic acid increases proliferation rate of GL-15 glioma cells, involving activation of STAT-3 transcription factor
E Paillaud, S Costa, C Fages, JL Plassat, C Rochette-Egly, C Monville, M Tardy |
Journal of Neuroscience Research | 2002 |
|
STAT1 and STAT3 mediate thrombin-induced expression of TIMP-1 in human glomerular mesangial cells
X Chen, W Liu, J Wang, X Wang, Z Yu |
Kidney International | 2002 |
|
Activation of Signal Transducer and Activator of Transcription 3 in Renal Cell Carcinoma:
A Horiguchi, M Oya, T Shimada, A Uchida, K Marumo, M Murai |
The Journal of Urology | 2002 |
|
COEXPRESSION OF ONCOSTATIN M AND ITS RECEPTORS AND EVIDENCE FOR STAT3 ACTIVATION IN HUMAN OVARIAN CARCINOMAS
TM Savarese, CL Campbell, C McQuain, K Mitchell, R Guardiani, PJ Quesenberry, BE Nelson |
Cytokine | 2002 |
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Activation of Signal Transducer and Activator of Transcription 3 in Renal Cell Carcinoma: A Study of Incidence and Its Association With Pathological Features and Clinical Outcome
A Horiguchi, M Oya, T Shimada, A Uchida, K Marumo, M Murai |
The Journal of Urology | 2002 |
|
Transforming growth factor α protects against Fas-mediated liver apoptosis in mice
D Kanda, H Takagi, M Toyoda, N Horiguchi, H Nakajima, T Otsuka, M Mori |
FEBS Letters | 2002 |
|
Expression of transforming growth factor-α, epidermal growth factor receptor and platelet-derived growth factors A and B in oropharyngeal cancers treated by curative radiation therapy
DM Aebersold, SC Froehlich, M Jonczy, KT Beer, J Laissue, RH Greiner, V Djonov |
Radiotherapy and Oncology | 2002 |
|
Inhibition of the JAK/STAT Signaling Pathway Prevents the High Glucose-Induced Increase in TGF- and Fibronectin Synthesis in Mesangial Cells
X Wang, S Shaw, F Amiri, DC Eaton, MB Marrero |
Diabetes | 2002 |
|
PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells
BM Steinberg, S Sun |
Journal of General Virology | 2002 |
|
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
G Niu, KL Wright, M Huang, L Song, E Haura, J Turkson, S Zhang, T Wang, D Sinibaldi, D Coppola, R Heller, LM Ellis, J Karras, J Bromberg, D Pardoll, R Jove, H Yu |
Oncogene | 2002 |
|
Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator
K Kaufmann, G Thiel |
Journal of Cellular Biochemistry | 2002 |
|
Differential function of STAT5 isoforms in head and neck cancer growth control
PL Leong, S Xi, SD Drenning, KF Dyer, AL Wentzel, EC Lerner, TE Smithgall, JR Grandis |
Oncogene | 2002 |
|
STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells
CY Yu, L Wang, A Khaletskiy, WL Farrar, A Larner, NH Colburn, JJ Li |
Oncogene | 2002 |
|
15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis and causes downregulation of Stat3 in human oral SCCa cells
NG Nikitakis, H Siavash, C Hebert, MA Reynolds, AW Hamburger, JJ Sauk |
British Journal of Cancer | 2002 |
|
Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway
M Kanai, Y Konda, T Nakajima, Y Izumi, N Kanda, A Nanakin, Y Kubohara, T Chiba |
Oncogene | 2002 |
|
Targeting epidermal growth factor receptor in head and neck cancer
AC Ford, JR Grandis |
Head & neck | 2002 |
|
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
G Niu, T Bowman, M Huang, S Shivers, D Reintgen, A Daud, A Chang, A Kraker, R Jove, H Yu |
Oncogene | 2002 |
|
The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil
Muneyuki Masuda, Satoshi Toh, Koji Koike, Yuichiro Kuratomi, Masumi Suzui, Atsuko Deguchi, Sohtaro Komiyama, I Bernard Weinstein |
Japanese journal of cancer research : Gann | 2002 |
|
Hormone Signaling
V Goffin, PA Kelly |
2002 | |
|
The Roles of JNK1 and Stat3 in the Response of Head and Neck Cancer Cell Lines to Combined Treatment with All trans‐retinoic Acid and 5‐Fluorouracil
Masuda M, Toh S, Koike K, Kuratomi Y, Suzui M, Deguchi A, Komiyama S, Weinstein IB |
Japanese journal of cancer research : Gann | 2002 |
|
Inhibition of stat3 signaling leads to apoptosis of leukemic large granular lymphocytes (LGL) and decreased MCL-1 expression
P.K. Epling-Burnette, Jin Hong Lui, Robyn Catlett-Falcone, James Turkson, Marc Oshiro, Ravi Kothapalli, Yongxiang Li, Ju-Ming Wang, Hsin-Fang Yang-Yen, James Karras, Richard Jove, Thomas P. Loughran, Jr. |
Journal of Clinical Investigation | 2001 |
|
Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma
CL Campbell, Z Jiang, DM Savarese, TM Savarese |
The American Journal of Pathology | 2001 |
|
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
Y Shen, G Devgan, JE Darnell, JF Bromberg |
Proceedings of the National Academy of Sciences | 2001 |
|
Targeting growth factor receptors: integration of novel therapeutics in the management of head and neck cancer
MN Lango, DM Shin, JR Grandis |
Current Opinion in Oncology | 2001 |
|
Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and BT474 breast carcinoma cells
G Brockhoff, P Hei�, J Schlegel, F Hofstaedter, R Knuechel |
Cytometry | 2001 |
|
Administration of Transforming Growth Factor-?? Reduces Infarct Volume After Transient Focal Cerebral Ischemia in the Rat
C Justicia, FJ P??rez-Asensio, MC Burguete, JB Salom, AM Planas |
Journal of Cerebral Blood Flow & Metabolism | 2001 |
|
Dysregulation of mammary Stats 1,3 and 5 and PRL receptors by overexpression of TGFα
MD Schroeder, TA Rose-Hellekant, EP Sandgren, LA Schuler |
Molecular and Cellular Endocrinology | 2001 |
|
Coexpression of granulocyte colony stimulating factor and its receptor in primary ovarian carcinomas
TM Savarese, K Mitchell, C McQuain, CL Campbell, R Guardiani, J Wuu, C Ollari, F Reale, BE Nelson, A Chen, PJ Quesenberry |
Cancer Letters | 2001 |
|
Activation of STAT proteins and growth control
JF Bromberg |
BioEssays | 2001 |
|
SO MANY LIGANDS, SO FEW TRANSCRIPTION FACTORS: A NEW PARADIGM FOR SIGNALING THROUGH THE STAT TRANSCRIPTION FACTORS
PS Subramaniam, BA Torres, HM Johnson |
Cytokine | 2001 |
|
MSK1 and JNKs Mediate Phosphorylation of STAT3 in UVA-irradiated Mouse Epidermal JB6 Cells
Y Zhang, G Liu, Z Dong |
The Journal of biological chemistry | 2001 |
|
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation
J Turkson, D Ryan, JS Kim, Y Zhang, Z Chen, E Haura, A Laudano, S Sebti, AD Hamilton, R Jove |
The Journal of biological chemistry | 2001 |
|
Identification of Tyrosine Residues in Constitutively Activated Fibroblast Growth Factor Receptor 3 Involved in Mitogenesis, Stat Activation, and Phosphatidylinositol 3-Kinase Activation
KC Hart, SC Robertson, DJ Donoghue, G Guidotti |
Molecular biology of the cell | 2001 |
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Signal transducer and activator of transcription 3 activation is required for Asp816 mutant c-Kit–mediated cytokine-independent survival and proliferation in human leukemia cells
ZQ Ning, J Li, RJ Arceci |
Blood | 2001 |
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Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils
PK Epling-Burnette, B Zhong, F Bai, K Jiang, RD Bailey, R Garcia, R Jove, JY Djeu, TP Loughran, S Wei |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
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Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development
J Bromberg |
Breast Cancer Research | 2000 |
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The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3
B Rödel, K Tavassoli, H Karsunky, T Schmidt, M Bachmann, F Schaper, P Heinrich, K Shuai, HP Elsässer, T Möröy |
The EMBO Journal | 2000 |
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Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
JR Grandis, SD Drenning, Q Zeng, SC Watkins, MF Melhem, S Endo, DE Johnson, L Huang, Y He, JD Kim |
Proceedings of the National Academy of Sciences | 2000 |
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Involvement of prolactin in breast cancer: redefining the molecular targets11Abbreviations: PRL, prolactin; PRLR, PRL receptor; GH, growth hormone; JAK, Janus kinase; STAT, signal transducer and activator of transcription; MAPK, Mitogen–activated protein kinase; PI 3-K, Phosphoinositide 3-kinase; FAK, focal–adhesion kinase; PKC, protein kinase C; SOCS, suppressor of cytokine signaling; PCD, programmed cell death
M Llovera, P Touraine, PA Kelly, V Goffin |
Experimental Gerontology | 2000 |
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STAT3 Regulates the Growth and Immunoglobulin Production of BCL1 B Cell Lymphoma through Control of Cell Cycle Progression
JG Karras, RA McKay, T Lu, J Pych, DA Frank, TL Rothstein, BP Monia |
Cellular Immunology | 2000 |
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Activation of the JAK/STAT pathway following transient focal cerebral ischemia: Signaling through Jak1 and Stat3 in astrocytes
C Justicia, C Gabriel, AM Planas |
Glia | 2000 |
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Interleukin-6 Signal Transduction and Lymphocyte Function
F Horn, C Henze, K Heidrich |
Immunobiology | 2000 |
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Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development
J Bromberg |
Breast Cancer Research | 2000 |
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Activation of the Stat3 Signaling Pathway Is Required for Differentiation by Interleukin-6 in PC12-E2 Cells
YY Wu, RA Bradshaw |
The Journal of biological chemistry | 2000 |
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Mechanism of STAT3 Activation by Insulin-like Growth Factor I Receptor
CS Zong, J Chan, DE Levy, C Horvath, HB Sadowski, LH Wang |
The Journal of biological chemistry | 2000 |
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Akt/Protein Kinase B Isoforms Are Differentially Regulated by Epidermal Growth Factor Stimulation
J Okano, I Gaslightwala, MJ Birnbaum, AK Rustgi, H Nakagawa |
The Journal of biological chemistry | 2000 |
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Epiregulin, a Novel Member of the Epidermal Growth Factor Family, Is an Autocrine Growth Factor in Normal Human Keratinocytes
Y Shirakata, T Komurasaki, H Toyoda, Y Hanakawa, K Yamasaki, S Tokumaru, K Sayama, K Hashimoto |
The Journal of biological chemistry | 2000 |
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STAT proteins: novel molecular targets for cancer drug discovery
J Turkson, R Jove |
Oncogene | 2000 |
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The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK–STAT activation
T Iwamoto, T Senga, Y Naito, S Matsuda, Y Miyake, A Yoshimura, M Hamaguchi |
Oncogene | 2000 |
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Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling
D Sinibaldi, W Wharton, J Turkson, T Bowman, WJ Pledger, R Jove |
Oncogene | 2000 |
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Transformation and Stat activation by derivatives of FGFR1, FGFR3 and FGFR4
KC Hart, SC Robertson, MY Kanemitsu, AN Meyer, JA Tynan, DJ Donoghue |
Oncogene | 2000 |
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STATs in oncogenesis
T Bowman, R Garcia, J Turkson, R Jove |
Oncogene | 2000 |
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STAT signaling in head and neck cancer
JI Song, JR Grandis |
Oncogene | 2000 |
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Epidermal Growth Factor Receptor???Mediated Stat3 Signaling Blocks Apoptosis in Head and Neck Cancer:
JR Grandis, Q Zeng, SD Drenning |
The Laryngoscope | 2000 |
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The Hepatocyte Review
MN Berry, AM Edwards |
2000 | |
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Activation of Signal Transducer and Activator of Transcription-3 during Proliferative Phases of 3T3-L1 Adipogenesis*
J Deng, K Hua, SS Lesser, JB Harp |
Endocrinology | 2000 |
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Growth factors in inflammatory bowel disease
PL Beck, DK Podolsky |
Inflammatory Bowel Diseases | 1999 |
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STAT signaling in the pathogenesis and treatment of cancer
DA Frank |
Molecular Medicine | 1999 |
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Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein
J Turkson, T Bowman, J Adnane, Y Zhang, JY Djeu, M Sekharam, DA Frank, LB Holzman, J Wu, S Sebti, R Jove |
Molecular and cellular biology | 1999 |
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STAT proteins as novel targets for cancer therapy
R Catlett-Falcone, WS Dalton, R Jove |
Current Opinion in Oncology | 1999 |
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EGF-Induced Activation of Stat1, Stat3, and Stat5b Is Unrelated to the Stimulation of DNA Synthesis in Cultured Hepatocytes
TK Guren, H Abrahamsen, GH Thoresen, E Babaie, T Berg, T Christoffersen |
Biochemical and Biophysical Research Communications | 1999 |
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ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells
A Fernandes, AW Hamburger, BI Gerwin |
International Journal of Cancer | 1999 |
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Potential Roles of Stat1 and Stat3 in Cellular Transformation
J Bromberg, J Darnell |
Cold Spring Harbor Symposia on Quantitative Biology | 1999 |
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Functional Roles of STAT Family Proteins: Lessons from Knockout Mice
S Akira |
Stem Cells | 1999 |
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Stat3 as an Oncogene
JF Bromberg, MH Wrzeszczynska, G Devgan, Y Zhao, RG Pestell, C Albanese, JE Darnell |
Cell | 1999 |
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Growth Factors in Inflammatory Bowel Disease:
PL Beck, DK Podolsky |
Inflammatory Bowel Diseases | 1999 |
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4. Stat Proteins and Cancer
T Bowman, R Jove |
Cancer control : journal of the Moffitt Cancer Center | 1999 |
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Signal Transducers and Activators of Transcription: Novel Targets for Anticancer Therapeutics
T Bowman, H Yu, S Sebti, W Dalton, R Jove |
Cancer control : journal of the Moffitt Cancer Center | 1999 |
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Progress in Brain Research
DE van Epps, L Saland, C Taylor, RC Williams |
Progress in brain research | 1983 |
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