Rheumatoid arthritis (RA) is an inflammatory disease associated with intense angiogenesis and vascular expression of integrin αvβ3. Intra-articular administration of a cyclic peptide antagonist of integrin αvβ3 to rabbits with antigen-induced arthritis early in disease resulted in inhibition of synovial angiogenesis and reduced synovial cell infiltrate, pannus formation, and cartilage erosions. These effects were not associated with lymphopenia or impairment of leukocyte function. Furthermore, when administered in chronic, preexisting disease, the αvβ3 antagonist effectively diminished arthritis severity and was associated with a quantitative increase in apoptosis of the angiogenic blood vessels. Therefore, angiogenesis appears to be a central factor in the initiation and persistence of arthritic disease, and antagonists of integrin αvβ3 may represent a novel therapeutic strategy for RA.
Chris M. Storgard, Dwayne G. Stupack, Alfred Jonczyk, Simon L. Goodman, Robert I. Fox, David A. Cheresh
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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R Terjung |
Comprehensive Physiology | 2011 |
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R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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R Terjung |
Comprehensive Physiology | 2011 |
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R Terjung |
Comprehensive Physiology | 2011 |
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R Terjung |
Comprehensive Physiology | 2011 |
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R Terjung |
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R Terjung |
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R Terjung |
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R Terjung |
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R Terjung |
Comprehensive Physiology | 2011 |
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R Terjung |
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R Terjung |
Comprehensive Physiology | 2011 |
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R Terjung |
Comprehensive Physiology | 2011 |
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R Terjung |
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R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Endothelial FAK as a therapeutic target in disease
GA Infusino, JR Jacobson |
Microvascular Research | 2011 |
αv Integrins in Angiogenesis and Cancer
SM Weis, DA Cheresh |
Cold Spring Harbor Perspectives in Medicine | 2011 |
Correlative BOLD MR imaging of stages of synovitis in a rabbit model of antigen-induced arthritis
AS Doria, A Crawley, H Gahunia, R Moineddin, T Rayner, V Tassos, A Zhong, K Pritzker, M Mendes, R Jong, RB Salter |
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Treatment of collagen-induced arthritis with recombinant plasminogen-related protein B: a novel inhibitor of angiogenesis
K Tanaka, T Morii, L Weissbach, K Horiuchi, K Takeuchi, Y Toyama, H Morioka |
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Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia
A Kennedy, CT Ng, TC Chang, M Biniecka, JN O'Sullivan, E Heffernan, U Fearon, DJ Veale |
Arthritis & Rheumatism | 2011 |
Beneficial effects of integrin v 3-blocking RGD peptides in early but not late phase of experimental glomerulonephritis
K Amann, CS Haas, J Schussler, C Daniel, A Hartner, HO Schocklmann |
Nephrology Dialysis Transplantation | 2011 |
Peptides targeting inflamed synovial vasculature attenuate autoimmune arthritis
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Proceedings of the National Academy of Sciences | 2011 |
Drug targeting systems for inflammatory disease: One for all, all for one
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Current Topics in Developmental Biology
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