Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
Maya Kansara, … , Igor B. Dawid, David M. Thomas
Maya Kansara, … , Igor B. Dawid, David M. Thomas
Published March 23, 2009
Citation Information: J Clin Invest. 2009;119(4):837-851. https://doi.org/10.1172/JCI37175.
View: Text | PDF
Research Article Article has an altmetric score of 6

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

  • Text
  • PDF
Abstract

Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and expansion and forms the basis for novel anabolic therapeutic strategies being developed for osteoporosis. These strategies include derepression of Wnt signaling by targeting secreted Wnt pathway antagonists, such as sclerostin. However, such therapies are associated with safety concerns regarding an increased risk of osteosarcoma, the most common primary malignancy of bone. Here, we analyzed 5 human osteosarcoma cell lines in a high-throughput screen for epigenetically silenced tumor suppressor genes and identified Wnt inhibitory factor 1 (WIF1), which encodes an endogenous secreted Wnt pathway antagonist, as a candidate tumor suppressor gene. In vitro, WIF1 suppressed β-catenin levels in human osteosarcoma cell lines, induced differentiation of human and mouse primary osteoblasts, and suppressed the growth of mouse and human osteosarcoma cell lines. Wif1 was highly expressed in the developing and mature mouse skeleton, and, although it was dispensable for normal development, targeted deletion of mouse Wif1 accelerated development of radiation-induced osteosarcomas in vivo. In primary human osteosarcomas, silencing of WIF1 by promoter hypermethylation was associated with loss of differentiation, increased β-catenin levels, and increased proliferation. These data lead us to suggest that derepression of Wnt signaling by targeting secreted Wnt antagonists in osteoblasts may increase susceptibility to osteosarcoma.

Authors

Maya Kansara, Michael Tsang, Laurent Kodjabachian, Natalie A. Sims, Melanie K. Trivett, Mathias Ehrich, Alexander Dobrovic, John Slavin, Peter F.M. Choong, Paul J. Simmons, Igor B. Dawid, David M. Thomas

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 2 1 3 6 9 4 7 4 6 9 9 18 12 13 15 13 8 139
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (139)

Title and authors Publication Year
Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma
Haskell A, Pan S, Reese R, Powers A, Lopez MG, Lomeli S, Story C, Benton J, Blazier JC, Kaunas R, Gregory CA
Scientific Reports 2025
Fabrication of Hard Tissue Constructs from Induced Pluripotent Stem Cells for Exploring Mechanisms of Hereditary Tooth/Skeletal Dysplasia
Kondo T, Thaweesapphithak S, Ambo S, Otake K, Ohori-Morita Y, Mori S, Vinaikosol N, Porntaveetus T, Egusa H
International Journal of Molecular Sciences 2025
CGREF1 modulates osteosarcoma proliferation by regulating the cell cycle through the Wnt/β-catenin signaling pathway
Wei Z, Xia K, Liu W, Huang X, Wei Z, Guo W
Molecular Medicine 2024
Self-Renewal and Pluripotency in Osteosarcoma Stem Cells' Chemoresistance: Notch, Hedgehog, and Wnt/β-Catenin Interplay with Embryonic Markers.
Martins-Neves SR, Sampaio-Ribeiro G, Gomes CMF
International journal of molecular sciences 2023
Dissection of Cellular Communication between Human Primary Osteoblasts and Bone Marrow Mesenchymal Stem Cells in Osteoarthritis at Single-Cell Resolution.
Liu Y, Chen Y, Li XH, Cao C, Zhang HX, Zhou C, Chen Y, Gong Y, Yang JX, Cheng L, Chen XD, Shen H, Xiao HM, Tan LJ, Deng HW
International journal of stem cells 2023
Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype.
Vaghjiani VG, Cochrane CR, Jayasekara WSN, Chong WC, Szczepny A, Kumar B, Martelotto LG, McCaw A, Carey K, Kansara M, Thomas DM, Walkley C, Mudge S, Gough DJ, Downie PA, Peacock CD, Matsui W, Watkins DN, Cain JE
Oncogene 2023
Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis
N Martínez-Gil, N Ugartondo, D Grinberg, S Balcells
Genes & development 2022
RecQ Helicase Somatic Alterations in Cancer
Thakkar MK, Lee J, Meyer S, Chang VY
Frontiers in Molecular Biosciences 2022
Origin and Therapies of Osteosarcoma
Moukengue B, Lallier M, Marchandet L, Baud\u2019huin M, Verrecchia F, Ory B, Lamoureux F
Cancers 2022
Role of extracellular vesicles in osteosarcoma.
Yang Q, Liu J, Wu B, Wang X, Jiang Y, Zhu D
International journal of medical sciences 2022
Integrated Analysis of TME and Hypoxia Identifies a Classifier to Predict Prognosis and Therapeutic Biomarkers in Soft Tissue Sarcomas
Xu R, Qi L, Ren X, Zhang W, Li C, Liu Z, Tu C, Li Z
Cancers 2022
Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders
Vlashi R, Zhang X, Wu M, Chen G
Genes & Diseases 2022
Direct conversion of osteosarcoma to adipocytes by targeting TNIK
Toru Hirozane, Mari Masuda, Teppei Sugano, Tetsuya Sekita, Naoko Goto, Toru Aoyama, Takato Sakagami, Yuko Uno, Hideki Moriyama, Masaaki Sawa, Naofumi Asano, Masaya Nakamura, Morio Matsumoto, Robert Nakayama, Tadashi Kondo, Akira Kawai, Eisuke Kobayashi, Tesshi Yamada
JCI Insight 2021
Mechanisms of Resistance to Conventional Therapies for Osteosarcoma
L Marchandet, M Lallier, C Charrier, M Baudhuin, B Ory, F Lamoureux
Cancers 2021
Selective Targeting of Class I Histone Deacetylases in a Model of Human Osteosarcoma
HM Torres, AM VanCleave, M Vollmer, DL Callahan, A Smithback, JM Conn, T Rodezno-Antunes, Z Gao, Y Cao, Y Afeworki, J Tao
Cancers 2021
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway
H Guo, J Peng, J Hu, S Chang, H Liu, H Luo, X Chen, H Tang, Y Chen
Journal of Bone Oncology 2021
The critical role of mesenchymal stromal/stem cell therapy in COVID ‐19 patients: An updated review
M Ebrahimi, MT Rad, A Zebardast, M Ayyasi, G Goodarzi, SS Tehrani
Cell Biochemistry and Function 2021
Usefulness of β-catenin expression in the differential diagnosis of osteosarcoma, osteoblastoma, and chondroblastoma
KE Erdogan, M Pacheco, M Gambarotti, G Magagnoli, M Sbaraglia, T Frisoni, A Righi, AP Tos
Virchows Archiv 2021
Antitumor Effect of Sclerostin against Osteosarcoma
Ideta H, Yoshida K, Okamoto M, Sasaki J, Kito M, Aoki K, Yoshimura Y, Suzuki S, Tanaka A, Takazawa A, Haniu H, Uemura T, Takizawa T, Sobajima A, Kamanaka T, Takahashi J, Kato H, Saito N
Cancers 2021
Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog
Kerekes K, Trexler M, Bányai L, Patthy L
Cells 2021
The Multifaceted Therapeutic Mechanisms of Curcumin in Osteosarcoma: State-of-the-Art.
Zahedipour F, Bolourinezhad M, Teng Y, Sahebkar A
Journal of Oncology 2021
Wnt signaling and Loxl2 promote aggressive osteosarcoma
K Matsuoka, L Bakiri, LI Wolff, M Linder, A Mikels-Vigdal, A Patiño-García, F Lecanda, C Hartmann, M Sibilia, EF Wagner
Cell Research 2020

Information Transfer and Biological Significance of Neoplastic Exosomes in the Tumor Microenvironment of Osteosarcoma


F Pu, F Chen, Z Zhang, J Liu, Z Shao
OncoTargets and therapy 2020
Molecular Biology of Osteosarcoma
AM Czarnecka, K Synoradzki, W Firlej, E Bartnik, P Sobczuk, M Fiedorowicz, P Grieb, P Rutkowski
Cancers 2020
lncRNA SNHG10 Promotes the Proliferation and Invasion of Osteosarcoma via Wnt/β-Catenin Signaling
S Zhu, Y Liu, X Wang, J Wang,
Molecular Therapy — Nucleic Acids 2020
Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation
Yujiao Han, Heng Feng, Jun Sun, Xiaoting Liang, Zhuo Wang, Wenhui Xing, Qinggang Dai, Yang Yang, Anjia Han, Zhanying Wei, Qing Bi, Hongbin Ji, Tiebang Kang, Weiguo Zou
Journal of Clinical Investigation 2019
Secretome profiling identifies Neuron-Derived Neurotrophic Factor as a tumor-suppressive factor in lung cancer
Ya Zhang, Xuefeng Wu, Yan Kai, Chia-Han Lee, Fengdong Cheng, Yixuan Li, Yongbao Zhuang, Javid Ghaemmaghami, Kun-Han Chuang, Zhuo Liu, Yunxiao Meng, Meghana H Keswani, Nancy R. Gough, Xiaojun Wu, Wenge Zhu, Alexandros Tzatsos, Weiqun Peng, Edward Seto, Eduardo M. Sotomayor, Xiaoyan Zheng
JCI Insight 2019
The Regulation of Bone Metabolism and Disorders by Wnt Signaling
K Maeda, Y Kobayashi, M Koide, S Uehara, M Okamoto, A Ishihara, T Kayama, M Saito, K Marumo
International journal of molecular sciences 2019
Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures
Y Wang, MF Sabbagh, X Gu, A Rattner, J Williams, J Nathans
eLife 2019
Gossypol Promotes Wnt/ β -Catenin Signaling through WIF1 in Ovariectomy-Induced Osteoporosis
J Liang, C Chen, H Liu, X Liu, H Zhao, J Hu
BioMed Research International 2019
Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas
N Asano, H Takeshima, S Yamashita, H Takamatsu, N Hattori, T Kubo, A Yoshida, E Kobayashi, R Nakayama, M Matsumoto, M Nakamura, H Ichikawa, A Kawai, T Kondo, T Ushijima
Scientific Reports 2019
Osteosarcoma progression is associated with increased nuclear levels and transcriptional activity of activated β-Catenin
N Ali, G Venkateswaran, E Garcia, T Landry, H McColl, C Sergi, A Persad, Y Abuetabh, DD Eisenstat, S Persad
Genes & cancer 2019
MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis
E Canalis
European Journal of Endocrinology 2018
Identification of Differentially Expressed Genes under the Regulation of Transcription Factors in Osteosarcoma
Y Liu, J Guan, X Chen
Pathology & Oncology Research 2018
An Eye on the Wnt Inhibitory Factor Wif1
L Poggi, S Casarosa, M Carl
Frontiers in Cell and Developmental Biology 2018
Targeting the Wnt/β-catenin pathway in human osteosarcoma cells
F Fang, A VanCleave, R Helmuth, H Torres, K Rickel, H Wollenzien, H Sun, E Zeng, J Zhao, J Tao
Oncotarget 2018
Wnt inhibitory factor 1 (WIF1) methylation and its association with clinical prognosis in patients with chondrosarcoma
P Liu, JK Shen, FJ Hornicek, F Liu, Z Duan
Scientific Reports 2017
Wnt Signaling in Ewing Sarcoma, Osteosarcoma, and Malignant Peripheral Nerve Sheath Tumors
MG Pridgeon, PJ Grohar, MR Steensma, BO Williams
Current Osteoporosis Reports 2017
The cardiac microenvironment uses non‐canonical WNT signaling to activate monocytes after myocardial infarction
IS Meyer, A Jungmann, C Dieterich, M Zhang, F Lasitschka, S Werkmeister, J Haas, OJ Müller, M Boutros, M Nahrendorf, HA Katus, SE Hardt, F Leuschner
EMBO Molecular Medicine 2017
Hypermethylation of WIF1 and its inhibitory role in the tumor growth of endometrial adenocarcinoma
X Deng, C Hou, H Wang, T Liang, L Zhu
Molecular medicine reports 2017
Advances in the Treatment of Pediatric Bone Sarcomas
PJ Grohar, KA Janeway, LD Mase, JD Schiffman
American Society of Clinical Oncology Educational Book 2017
Advances in the Treatment of Pediatric Bone Sarcomas.
Grohar PJ, Janeway KA, Mase LD, Schiffman JD
2017
Sclerostin expression in skeletal sarcomas
J Shen, CA Meyers, S Shrestha, A Singh, G LaChaud, V Nguyen, G Asatrian, N Federman, N Bernthal, FC Eilber, SM Dry, K Ting, C Soo, AW James
Human Pathology 2016
Glucocorticoids Hijack Runx2 to Stimulate Wif1 for Suppression of Osteoblast Growth and Differentiation: GCs AND Runx2 SYNERGISTICALLY STIMULATE Wif1
E Morimoto, M Li, AB Khalid, SA Krum, NO Chimge, B Frenkel
Journal of Cellular Physiology 2016
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance
MK Mohammed, C Shao, J Wang, Q Wei, X Wang, Z Collier, S Tang, H Liu, F Zhang, J Huang, D Guo, M Lu, F Liu, J Liu, C Ma, LL Shi, A Athiviraham, TC He, MJ Lee
Genes & Diseases 2016
High Expression of XRCC6 Promotes Human Osteosarcoma Cell Proliferation through the β-Catenin/Wnt Signaling Pathway and Is Associated with Poor Prognosis
B Zhu, D Cheng, S Li, S Zhou, Q Yang
International journal of molecular sciences 2016
Molecular genetics of osteosarcoma
K Rickel, F Fang, J Tao
Bone 2016
Deciphering signaling networks in osteosarcoma pathobiology
C Adamopoulos, AN Gargalionis, EK Basdra, AG Papavassiliou
Experimental biology and medicine (Maywood, N.J.) 2016
Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling
S Danopoulos, M Krainock, O Toubat, M Thornton, B Grubbs, DA Alam
American journal of physiology. Lung cellular and molecular physiology 2016
Knockdown of SALL4 Inhibits Proliferation, Migration, and Invasion in Osteosarcoma Cells.
Zhang D, Jiang F, Wang X, Li G
Oncology research 2016
Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma.
Shu J, Li L, Sarver AE, Pope EA, Varshney J, Thayanithy V, Spector L, Largaespada DA, Steer CJ, Subramanian S
Oncotarget 2016
The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice
C Baldauf, A Jeschke, V Kanbach, P Catala-Lehnen, D Baumhoer, H Gerull, S Buhs, M Amling, P Nollau, S Harroch, T Schinke, L Malaval
PloS one 2015
Sclerostin and skeletal health
M Sharifi, L Ereifej, EM Lewiecki
Reviews in Endocrine and Metabolic Disorders 2015
Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway
G Sharma, AR Sharma, EM Seo, JS Nam
BioMed Research International 2015
Hedgehog/Patched-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells
F Nitzki, N Cuvelier, J Dräger, A Schneider, T Braun, H Hahn
Oncogene 2015
Aberrant CXCR4 and β-catenin expression in osteosarcoma correlates with patient survival
Y Lu, GF Guan, J Chen, B Hu, C Sun, Q Ma, YH Wen, XC Qiu, Y Zhou
Oncology Letters 2015
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies
K Yang, X Wang, H Zhang, Z Wang, G Nan, Y Li, F Zhang, MK Mohammed, RC Haydon, HH Luu, Y Bi, TC He
Laboratory Investigation 2015
Regulation of osteosarcoma cell invasion through osteopontin modification by miR-4262
K Song, N Liu, Y Yang, X Qiu
Tumor Biology 2015
Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells
C Chen, M Zhao, A Tian, X Zhang, Z Yao, X Ma
Oncotarget 2015
Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies
Morrow JJ, Khanna C
Critical Reviews in Oncogenesis 2015
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes
R Brommage, J Liu, GM Hansen, LL Kirkpatrick, DG Potter, AT Sands, B Zambrowicz, DR Powell, P Vogel
Bone Research 2014
Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies
PJ Marie
Cellular and Molecular Life Sciences 2014
An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity
U Krause, DM Ryan, BH Clough, CA Gregory
Cell Death and Disease 2014
The genetic basis for inactivation of Wnt pathway in human osteosarcoma
X Du, J Yang, D Yang, W Tian, Z Zhu
BMC Cancer 2014
Treatment of post-menopausal osteoporosis: beyond bisphosphonates
S Ishtiaq, I Fogelman, G Hampson
Journal of Endocrinological Investigation 2014
Epigenetic alterations in osteosarcoma: promising targets
B Li, Z Ye
Molecular Biology Reports 2014
Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations
RC Ng, D Matsumaru, AS Ho, MM Garcia-Barceló, ZW Yuan, D Smith, L Kodjabachian, PK Tam, G Yamada, VC Lui
Cell Death and Differentiation 2014
Induction of WNT inhibitory factor 1 expression by Müllerian inhibiting substance/antiMullerian hormone in the Müllerian duct mesenchyme is linked to Müllerian duct regression
JH Park, Y Tanaka, NA Arango, L Zhang, LA Benedict, MI Roh, PK Donahoe, JM Teixeira
Developmental Biology 2014
Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence
I Ramachandran, V Ganapathy, E Gillies, I Fonseca, SM Sureban, CW Houchen, A Reis, L Queimado
Cell Death and Disease 2014
Separate and Combined Effects of DNMT and HDAC Inhibitors in Treating Human Multi-Drug Resistant Osteosarcoma HosDXR150 Cell Line
E Capobianco, A Mora, DL Sala, A Roberti, N Zaki, E Badidi, M Taranta, C Cinti
PloS one 2014
Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases
EM Lewiecki
Therapeutic Advances in Musculoskeletal Diseases 2014
Notch Activation as a Driver of Osteogenic Sarcoma
J Tao, MM Jiang, L Jiang, JS Salvo, HC Zeng, B Dawson, TK Bertin, PH Rao, R Chen, LA Donehower, F Gannon, BH Lee
Cancer Cell 2014
Translational biology of osteosarcoma
M Kansara, MW Teng, MJ Smyth, DM Thomas
Nature Reviews Cancer 2014
Focal Chromosomal Copy Number Aberrations Identify CMTM8 and GPR177 as New Candidate Driver Genes in Osteosarcoma
J Both, O Krijgsman, J Bras, GR Schaap, F Baas, B Ylstra, TJ Hulsebos, D Loeb
PloS one 2014
A monoclonal antibody against the wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model
SD Goldstein, M Trucco, WB Guzman, M Hayashi, DM Loeb
Oncotarget 2014
Whole exome sequencing of a single osteosarcoma case—integrative analysis with whole transcriptome RNA-seq data
Reimann E, Kõks S, Ho XD, Maasalu K, Märtson A
Human genomics 2014
TIKI2 suppresses growth of osteosarcoma by targeting Wnt/β-catenin pathway.
Li R, Liu J, Wu H, Liu L, Wang L, Zhang S
Molecular and Cellular Biochemistry 2014
Wnt/β-catenin pathway in bone cancers.
Tian J, He H, Lei G
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014
Immune tumor suppressor functions of RB1 in radiation induced osteosarcoma
Maya Kansara, Huei San Leong, Dan Mei Lin, Sophie Popkiss, Puiyi Pang, Dale Garsed, Carl Walkley, Carleen Cullinane, Jason Ellul, Nicole Haynes, Rodney Hicks, Marieke Kuijjer, Anne Marie Cleton-Jansen, Philip Hinds, Mark J. Smyth, David M. Thomas
Journal of Clinical Investigation 2013
WNT signaling in bone homeostasis and disease: from human mutations to treatments
R Baron, M Kneissel
Nature Medicine 2013
FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo
J Brun, FX Dieudonné, C Marty, J Müller, R Schüle, A Patiño-García, F Lecanda, O Fromigué, PJ Marie
PloS one 2013
Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy
Y Ma, R Ren, EQ Han, H Li, D Chen, JJ Jacobs, S Gitelis, RJ O’Keefe, YT Konttinen, G Yin, TF Li
Biochemical and Biophysical Research Communications 2013
Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells
JE Cain, A McCaw, WS Jayasekara, FJ Rossello, KD Marini, AT Irving, M Kansara, DM Thomas, DM Ashley, DN Watkins
Sarcoma 2013
Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches
E Canalis
Nature Reviews Endocrinology 2013
Wnt signaling in bone formation and its therapeutic potential for bone diseases
JH Kim, X Liu, J Wang, X Chen, H Zhang, SH Kim, J Cui, R Li, W Zhang, Y Kong, J Zhang, W Shui, J Lamplot, MR Rogers, C Zhao, N Wang, P Rajan, J Tomal, J Statz, N Wu, HH Luu, RC Haydon, TC He
Therapeutic Advances in Musculoskeletal Diseases 2013
Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer
JP Roperch, R Incitti, S Forbin, F Bard, H Mansour, F Mesli, I Baumgaertner, F Brunetti, I Sobhani
BMC Cancer 2013
The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
EW Stratford, J Daffinrud, E Munthe, R Castro, J Waaler, S Krauss, O Myklebost
Cancer Medicine 2013
The prognostic significance of CD44V6, CDH11, and β-catenin expression in patients with osteosarcoma
Z Deng, G Niu, L Cai, R Wei, X Zhao
BioMed Research International 2013
MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma
M der Deen, H Taipaleenmäki, Y Zhang, NM Teplyuk, A Gupta, S Cinghu, K Shogren, A Maran, MJ Yaszemski, L Ling, SM Cool, DT Leong, C Dierkes, J Zustin, M Salto-Tellez, Y Ito, SC Bae, M Zielenska, JA Squire, JB Lian, JL Stein, GP Zambetti, SN Jones, M Galindo, E Hesse, GS Stein, AJ van Wijnen
The Journal of biological chemistry 2013
The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi
A Avanesov, SS Blair
Development (Cambridge, England) 2013
Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives
R Baron, E Hesse
The Journal of clinical endocrinology and metabolism 2012
Secreted and Transmembrane Wnt Inhibitors and Activators
CM Cruciat, C Niehrs
Cold Spring Harbor perspectives in biology 2012
Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells
J Wei, F Fang, AP Lam, JL Sargent, E Hamburg, ME Hinchcliff, CJ Gottardi, R Atit, ML Whitfield, J Varga
Arthritis & Rheumatism 2012
Perspectives on cancer stem cells in osteosarcoma
U Basu-Roy, C Basilico, A Mansukhani
Cancer Letters 2012
A systems biology approach reveals common metastatic pathways in osteosarcoma
RJ Flores, Y Li, A Yu, J Shen, PH Rao, SS Lau, M Vannucci, CC Lau, TK Man
BMC Systems Biology 2012
The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling
A Avanesov, SM Honeyager, J Malicki, SS Blair
PLoS genetics 2012
WNT signalling pathways as therapeutic targets in cancer
JN Anastas, RT Moon
Nature Reviews Cancer 2012
Treatment of osteoporosis in men
JM Kaufman, JY Reginster, S Boonen, ML Brandi, C Cooper, W Dere, JP Devogelaer, A Diez-Perez, JA Kanis, E McCloskey, B Mitlak, E Orwoll, JD Ringe, G Weryha, R Rizzoli
Bone 2012
β-Catenin Does Not Confer Tumorigenicity When Introduced into Partially Transformed Human Mesenchymal Stem Cells
S Piperdi, L Austin-Page, D Geller, M Ahluwalia, S Gorlick, J Gill, A Park, W Zhang, N Li, SH Chung, R Gorlick
Sarcoma 2012
Immunohistochemical investigation of cell cycle and apoptosis regulators (survivin, β-catenin, p53, caspase 3) in canine appendicular osteosarcoma
L Bongiovanni, F Mazzocchetti, D Malatesta, M Romanucci, A Ciccarelli, P Buracco, RD Maria, C Palmieri, M Martano, E Morello, L Maniscalco, LD Salda
BMC veterinary research 2012
Effects of fulvestrant on biological activity and Wnt expression in rat GH3 cells
Jiwei Bai, Yan Wang, Chuzhong Li, Yazhuo Zhang
NEURAL REGEN RES 2012
Wnt Inhibitory Factor 1 (Wif1) Is Regulated by Androgens and Enhances Androgen-Dependent Prostate Development
KP Keil, V Mehta, AM Branam, LL Abler, RA Buresh-Stiemke, PS Joshi, CT Schmitz, PC Marker, CM Vezina
Endocrinology 2012
Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis
KA Fantauzzo, AM Christiano
Development (Cambridge, England) 2012
Control of bone formation by the serpentine receptor Frizzled-9
J Albers, J Schulze, FT Beil, M Gebauer, A Baranowsky, J Keller, RP Marshall, K Wintges, FW Friedrich, M Priemel, AF Schilling, JM Rueger, K Cornils, B Fehse, T Streichert, G Sauter, F Jakob, KL Insogna, B Pober, KP Knobeloch, U Francke, M Amling, T Schinke
The Journal of Cell Biology 2011
Osteoporosis: now and the future
TD Rachner, S Khosla, LC Hofbauer
Lancet 2011
Emerging Therapeutic Opportunities for Skeletal Restoration
M Kawai, UI Mödder, S Khosla, CJ Rosen
Nature reviews. Drug discovery 2011
Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas
U Basu-Roy, E Seo, L Ramanathapuram, TB Rapp, JA Perry, SH Orkin, A Mansukhani, C Basilico
Oncogene 2011
Wnt signaling is activated at high frequency and drives proliferation of multiple human sarcoma subtypes through a TCF/β-catenin target gene, CDC25A
S Vijayakumar, G Liu, IA Rus, S Yao, Y Chen, G Akiri, L Grumolato, SA Aaronson
Cancer Cell 2011
Wnt10b Activates the Wnt, Notch and NFκB Pathways in U2OS Osteosarcoma Cells
UI Mödder, MJ Oursler, S Khosla, DG Monroe
Journal of Cellular Biochemistry 2011
Characterization of β-catenin expression in canine osteosarcoma
TJ Stein, KE Holmes, A Muthuswamy, V Thompson, MK Huelsmeyer
Veterinary and Comparative Oncology 2011
Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature
J PosthumaDeBoer, MA Witlox, GJ Kaspers, BJ van Royen
Clinical & Experimental Metastasis 2011
Influence of β-catenin small interfering RNA on human osteosarcoma cells
F Zhang, A Chen, J Chen, T Yu, F Guo
Journal of Huazhong University of Science and Technology [Medical Sciences] 2011
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1
T Malinauskas, AR Aricescu, W Lu, C Siebold, EY Jones
Nature Structural & Molecular Biology 2011
Osteosarcomagenesis: Modeling Cancer Initiation in the Mouse
KB Jones
Sarcoma 2011
Update on Wnt signaling in bone cell biology and bone disease
DG Monroe, ME McGee-Lawrence, MJ Oursler, JJ Westendorf
Gene 2011
New understanding and treatments for osteoporosis
G Mazziotti, J Bilezikian, E Canalis, D Cocchi, A Giustina
Endocrine 2011
Cyclin E1 Is Amplified and Overexpressed in Osteosarcoma
WW Lockwood, D Stack, T Morris, D Grehan, C O'Keane, GL Stewart, J Cumiskey, WL Lam, JA Squire, DM Thomas, MJ O'Sullivan
The Journal of molecular diagnostics : JMD 2011
Regulation of breast cancer-induced bone lesions by β-catenin protein signaling
Y Chen, HY Shi, SR Stock, PH Stern, M Zhang
The Journal of biological chemistry 2011
PRKAR1A is an Osteosarcoma Tumor Suppressor and Defines a Molecular Subclass in Mice
Sam D Molyneux, Marco Di Grappa, Alexander G Beristain, Trevor D Mckee, Daniel H Wai, Jana Paderova, Meenakshi Kashyap, Pingzhao Hu, Tamara Maiuri, Swami R Narala, Vuk Stambolic, Jeremy Squire, Josef Penninger, Otto Sanchez, Timothy J Triche, Geoffrey A Wood, Lawrence S. Kirschner, Rama Khokha
Journal of Clinical Investigation 2010
New Treatment Modalities in Osteoporosis
E Canalis
Endocrine Practice 2010
Update in new anabolic therapies for osteoporosis
E Canalis
The Journal of clinical endocrinology and metabolism 2010
ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells
SA Maas, NM Donghia, K Tompkins, O Foreman, KD Mills
BMC Biology 2010
The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging
MR Haussler, CA Haussler, GK Whitfield, JC Hsieh, PD Thompson, TK Barthel, L Bartik, JB Egan, Y Wu, JL Kubicek, CL Lowmiller, EW Moffet, RE Forster, PW Jurutka
The Journal of Steroid Biochemistry and Molecular Biology 2010
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
S Kalari, GP Pfeifer
Advances in genetics 2010
Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone
L Endo-Munoz, A Cumming, S Sommerville, I Dickinson, NA Saunders
British Journal of Cancer 2010
Sclerostin: Current Knowledge and Future Perspectives
MJ Moester, SE Papapoulos, CW Löwik, RL van Bezooijen
Calcified Tissue International 2010
Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5
A Lewis, S Segditsas, M Deheragoda, P Pollard, R Jeffery, E Nye, H Lockstone, H Davis, S Clark, G Stamp, R Poulsom, N Wright, I Tomlinson
Gut 2010
The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
DS Yee, Y Tang, X Li, Z Liu, Y Guo, S Ghaffar, P McQueen, D Atreya, J Xie, AR Simoneau, BH Hoang, X Zi
Molecular Cancer 2010
Wnt Inhibitory Factor 1 Decreases Tumorigenesis and Metastasis in Osteosarcoma
EM Rubin, Y Guo, K Tu, J Xie, X Zi, BH Hoang
Molecular cancer therapeutics 2010
Matrix Metalloproteinase (MMP)-13 Regulates Mammary Tumor–Induced Osteolysis by Activating MMP9 and Transforming Growth Factor-β Signaling at the Tumor-Bone Interface
KC Nannuru, M Futakuchi, ML Varney, TM Vincent, EG Marcusson, RK Singh
Cancer research 2010
Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells.
Leow PC, Tian Q, Ong ZY, Yang Z, Ee PL
Investigational New Drugs 2010
Wnt therapy for bone loss: golden goose or Trojan horse?
Greg H. Enders
Journal of Clinical Investigation 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Growth factor control of bone mass
E Canalis
Journal of Cellular Biochemistry 2009
Promising bone-related therapeutic targets for rheumatoid arthritis
Y Choi, JR Arron, MJ Townsend
Nature Reviews Rheumatology 2009
Wnt antagonists: for better or worse?
RJ Lories, FP Luyten
Nature Reviews Rheumatology 2009
Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfβ in osteosarcoma cells
IA san Martin, N Varela, M Gaete, K Villegas, M Osorio, JC Tapia, M Antonelli, EE Mancilla, BP Pereira, SS Nathan, JB Lian, JL Stein, GS Stein, AJ van Wijnen, M Galindo
Journal of Cellular Physiology 2009
Wnt modulators in the biotech pipeline
JP Rey, DL Ellies
Developmental Dynamics 2009
Beyond oncology--application of HPMA copolymers in non-cancerous diseases
XM Liu, SC Miller, D Wang
Advanced Drug Delivery Reviews 2009

← Previous 1 2 3 4 5 6 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 5 patents
123 readers on Mendeley
1 readers on CiteULike
See more details