Citations to this article

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.
T C van der Pouw Kraan, … , R Leurs, L A Aarden
T C van der Pouw Kraan, … , R Leurs, L A Aarden
Published November 15, 1998
Citation Information: J Clin Invest. 1998;102(10):1866-1873. https://doi.org/10.1172/JCI3692.
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Research Article

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.

Abstract

IL-12 is essential for T helper 1 (Th1) development and inhibits the induction of Th2 responses. Atopic diseases, which are characterized by Th2 responses, are associated with the overproduction of histamine. Here we present evidence that histamine, at physiological concentrations, strongly inhibits human IL-12 p40 and p70 mRNA and protein production by human monocytes. The use of specific histamine receptor antagonists reveals that this inhibition is mediated via the H2 receptor and induction of intracellular cAMP. The inhibition of IL-12 production is independent of IL-10 and IFN-gamma. The observation that histamine strongly reduces the production of the Th1-inducing cytokine IL-12 implies a positive feedback mechanism for the development of Th2 responses in atopic patients.

Authors

T C van der Pouw Kraan, A Snijders, L C Boeije, E R de Groot, A E Alewijnse, R Leurs, L A Aarden

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Are the anti-allergic properties of H1-antihistamines of any clinical relevance?
G Marone, F Granata, C Palumbo, M Gentile, M Triggiani 		Revue Française d'Allergologie et d'Immunologie Clinique 2000
LYMPHOID TISSUES AND THE IMMUNE SYSTEM IN MASTOCYTOSIS
YA Mekori 		Hematology/Oncology Clinics of North America 2000
The role of IL-12 in the induction of late-phase cellular infiltration in a murine model of allergic conjunctivitis
MT Magone, SM Whitcup, A Fukushima, CC Chan, PB Silver, LV Rizzo 		Journal of Allergy and Clinical Immunology 2000
Regulation of Helper T Cell Differentiation and Recruitment in Airway Inflammation
F Sinigaglia, D D'ambrosio 		American journal of respiratory and critical care medicine 2000
Atopic Allergy: A Failure of Antigen-Presenting Cells to Properly Polarize Helper T Cells?
ML Kapsenberg, CM Hilkens, TI van der POUW KRAAN, EA Wierenga, P Kalinski 		American journal of respiratory and critical care medicine 2000
Microenvironmental influences in atopic disease
Holloway, Gudin 		Cell 2000
Histamine Is a Potent Inducer of IL-18 and IFN-γ in Human Peripheral Blood Mononuclear Cells
H Kohka, M Nishibori, H Iwagaki, N Nakaya, T Yoshino, K Kobashi, K Saeki, N Tanaka, T Akagi 		Journal of immunology (Baltimore, Md. : 1950) 2000
Δ 9 -Tetrahydrocannabinol Treatment Suppresses Immunity and Early IFN-γ, IL-12, and IL-12 Receptor β2 Responses to Legionella pneumophila Infection
TW Klein, CA Newton, N Nakachi, H Friedman 		Journal of immunology (Baltimore, Md. : 1950) 2000
Inhibition of IL-12 Production in Human Monocyte-Derived Macrophages by TNF
X Ma, J Sun, E Papasavvas, H Riemann, S Robertson, J Marshall, RT Bailer, A Moore, RP Donnelly, G Trinchieri, LJ Montaner 		Journal of immunology (Baltimore, Md. : 1950) 2000
Development of Th1-Inducing Capacity in Myeloid Dendritic Cells Requires Environmental Instruction
PL Vieira, EC de Jong, EA Wierenga, ML Kapsenberg, P Kaliński 		Journal of immunology (Baltimore, Md. : 1950) 2000
Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function
F Sinigaglia, D D'Ambrosio, P Panina-Bordignon, L Rogge 		Immunological Reviews 1999
IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responses
G Haskó, C Szabó 		British Journal of Pharmacology 1999
Interleukin-12 and allergic tissue response
Camporota, Holloway 		Cell 1999
T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal
P Kaliński, C M Hilkens, E A Wierenga, M L Kapsenberg 		Immunology Today 1999

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