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Citations to this article

Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family
H. Michael Shepard, … , Cathleen M. Brdlik, Hans Schreiber
H. Michael Shepard, … , Cathleen M. Brdlik, Hans Schreiber
Published November 3, 2008
Citation Information: J Clin Invest. 2008;118(11):3574-3581. https://doi.org/10.1172/JCI36049.
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Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family

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Abstract

The human EGFR (HER) family is essential for communication between many epithelial cancer cell types and the tumor microenvironment. Therapeutics targeting the HER family have demonstrated clinical success in the treatment of diverse epithelial cancers. Here we propose that the success of HER family–targeted monoclonal antibodies in cancer results from their ability to interfere with HER family consolidation of signals initiated by a multitude of other receptor systems. Ligand/receptor systems that initiate these signals include cytokine receptors, chemokine receptors, TLRs, GPCRs, and integrins. We further extrapolate that improvements in cancer therapeutics targeting the HER family are likely to incorporate mechanisms that block or reverse stromal support of malignant progression by isolating the HER family from autocrine and stromal influences.

Authors

H. Michael Shepard, Cathleen M. Brdlik, Hans Schreiber

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Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
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