Overconsumption of lipid-rich diets, in conjunction with physical inactivity, disables and kills staggering numbers of people worldwide. Recent advances in our molecular understanding of cholesterol and triglyceride transport from the small intestine to the rest of the body provide a detailed picture of the fed/fasted and active/sedentary states. Key surprises include the unexpected nature of many pivotal molecular mediators, as well as their dysregulation — but possible reversibility — in obesity, diabetes, inactivity, and related conditions. These mechanistic insights provide new opportunities to correct dyslipoproteinemia, accelerated atherosclerosis, insulin resistance, and other deadly sequelae of overnutrition and underexertion.
Kevin Jon Williams
Title and authors | Publication | Year |
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Multi-layer regulation of postprandial triglyceride metabolism in response to acute cold exposure
Yiliang Zhang, Shengyang Zhou, Runming Zhao, Chunyu Xiong, Yingzhen Huang, Minzhu zhang, Yan Wang |
Journal of lipid research | 2025 |
Control of Cholesterol Metabolism Using a Systems Approach
Formanowicz D, Radom M, Rybarczyk A, Tanaś K, Formanowicz P |
Biology | 2022 |
Causes, clinical findings and therapeutic options in chylomicronemia syndrome, a special form of hypertriglyceridemia
Paragh G, Németh Á, Harangi M, Banach M, Fülöp P |
Lipids in Health and Disease | 2022 |
Association Between Increased Lipid Profiles and Risk of Diabetic Retinopathy in a Population-Based Case-Control Study
Liu Z, Shao M, Ren J, Qiu Y, Li S, Cao W |
Journal of inflammation research | 2022 |
Physiological Bases for the Superiority of Apolipoprotein B Over Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk.
Glavinovic T, Thanassoulis G, de Graaf J, Couture P, Hegele RA, Sniderman AD |
Journal of the American Heart Association | 2022 |
Heat Shock Alters the Proteomic Profile of Equine Mesenchymal Stem Cells
Abd-El-Aziz A, Riveroll A, Esparza-Gonsalez B, McDuffee L, Cohen AM, Fenech AL, Montelpare WJ |
International journal of molecular sciences | 2022 |
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
J Borén, MJ Chapman, RM Krauss, CJ Packard, JF Bentzon, CJ Binder, MJ Daemen, LL Demer, RA Hegele, SJ Nicholls, BG Nordestgaard, GF Watts, E Bruckert, S Fazio, BA Ference, I Graham, JD Horton, U Landmesser, U Laufs, L Masana, G Pasterkamp, FJ Raal, KK Ray, H Schunkert, MR Taskinen, B van de Sluis, O Wiklund, L Tokgozoglu, AL Catapano, HN Ginsberg |
European Heart Journal | 2020 |
The Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in Humans
J Borén, CJ Packard, MR Taskinen |
Frontiers in Endocrinology | 2020 |
Anthocyanin‐Biofortified Colored Wheat Prevents High Fat Diet–Induced Alterations in Mice: Nutrigenomics Studies
S Sharma, P Khare, A Kumar, V Chunduri, A Kumar, P Kapoor, P Mangal, KK Kondepudi, M Bishnoi, M Garg |
Molecular Nutrition & Food Research | 2020 |
Unraveling the regulatory role of endoplasmic-reticulum-associated degradation in tumor immunity
X Qin, WD Denton, LN Huiting, KS Smith, H Feng |
Critical Reviews in Biochemistry and Molecular Biology | 2020 |
Cold exposure induces dynamic, heterogeneous alterations in human brown adipose tissue lipid content
CL Coolbaugh, BM Damon, EC Bush, EB Welch, TF Towse |
Scientific Reports | 2019 |
Model systems for studying the assembly, trafficking, and secretion of apoB lipoproteins using fluorescent fusion proteins
MT Walsh, OM Celestin, JH Thierer, S Rajan, SA Farber, MM Hussain |
Journal of lipid research | 2019 |
Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
C Liu, T Han, DL Stachura, H Wang, BL Vaisman, J Kim, RL Klemke, AT Remaley, TM Rana, D Traver, YI Miller |
Nature Communications | 2018 |
Hepatic dysfunction and thrombocytopenia induced by excess sFlt1 in mice lacking endothelial nitric oxide synthase
Y Oe, M Ko, T Fushima, E Sato, SA Karumanchi, H Sato, J Sugawara, S Ito, N Takahashi |
Scientific Reports | 2018 |
Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications
A Gómez-Hernández, N Beneit, S Díaz-Castroverde, Ó Escribano |
International Journal of Endocrinology | 2016 |
The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction
GL Sasso, WK Schlage, S Boué, E Veljkovic, MC Peitsch, J Hoeng |
Journal of Translational Medicine | 2016 |
LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages
AP Lillis, SC Muratoglu, DT Au, M Migliorini, MJ Lee, SK Fried, I Mikhailenko, DK Strickland, P Aspichueta |
PloS one | 2015 |
Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
D Gnocchi, M Pedrelli, E Hurt-Camejo, P Parini |
Biology : open access journal | 2015 |
Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans
M Adiels, A Mardinoglu, MR Taskinen, J Borén |
Frontiers in physiology | 2015 |
A Liver-Enriched Long Non-Coding RNA, lncLSTR, Regulates Systemic Lipid Metabolism in Mice
P Li, X Ruan, L Yang, K Kiesewetter, Y Zhao, H Luo, Y Chen, M Gucek, J Zhu, H Cao |
Cell Metabolism | 2015 |
Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route
M Murakami, K Nishina, C Watanabe, K Yoshida-Tanaka, W Piao, H Kuwahara, Y Horikiri, K Miyata, N Nishiyama, K Kataoka, M Yoshida, H Mizusawa, T Yokota |
Scientific Reports | 2015 |
Effect of Hypericum perforatum L. Extract on Insulin Resistance and Lipid Metabolic Disorder in High-Fat-Diet Induced Obese Mice: EHP, A POTENTIAL DRUG FOR THE METABOLIC SYNDROME TREATMENT
J Tian, R Tao, X Zhang, Q Liu, Y He, Y Su, T Ji, F Ye |
Phytotherapy Research | 2014 |
Intestinal lipid absorption and lipoprotein formation:
MM Hussain |
Current Opinion in Lipidology | 2014 |
Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs
J Iqbal, M Boutjdir, LL Rudel, MM Hussain |
Journal of lipid research | 2014 |
SULF2 strongly prediposes to fasting and postprandial triglycerides in patients with obesity and type 2 diabetes mellitus: SULF2 and Triglycerides in Obesity
HC Hassing, RP Surendran, B Derudas, A Verrijken, SM Francque, HL Mooij, SJ Moens, LM Hart, G Nijpels, JM Dekker, KJ Williams, ES Stroes, LF van Gaal, B Staels, M Nieuwdorp, GM Dallinga-Thie |
Obesity | 2014 |
The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism
H Sha, S Sun, AB Francisco, N Ehrhardt, Z Xue, L Liu, P Lawrence, F Mattijssen, RD Guber, MS Panhwar, JT Brenna, H Shi, B Xue, S Kersten, A Bensadoun, M Péterfy, Q Long, L Qi |
Cell Metabolism | 2014 |
Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies
JJ Geerling, MR Boon, S Kooijman, ET Parlevliet, LM Havekes, JA Romijn, IM Meurs, PC Rensen |
Journal of lipid research | 2013 |
Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease
DJ Felmlee, ML Hafirassou, M Lefevre, TF Baumert, C Schuster |
Viruses | 2013 |
Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects
N Matikainen, MA Burza, S Romeo, A Hakkarainen, M Adiels, L Folkersen, P Eriksson, N Lundbom, E Ehrenborg, M Orho-Melander, MR Taskinen, J Borén |
PloS one | 2013 |
Regulating intestinal function to reduce atherogenic lipoproteins
MM Hussain, TM Leung, L Zhou, S Abu-Merhi |
Clinical Lipidology | 2013 |
Molecular mediators for raft-dependent endocytosis of syndecan-1, a highly conserved, multifunctional receptor
K Chen, KJ Williams |
The Journal of biological chemistry | 2013 |
The Chylomicron: Relationship to Atherosclerosis
GH Tomkin, D Owens |
International Journal of Vascular Medicine | 2012 |
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness
X Wu, KJ Williams |
Arteriosclerosis, thrombosis, and vascular biology | 2012 |
A new, powerful player in lipoprotein metabolism: brown adipose tissue
A Bartelt, M Merkel, J Heeren |
Journal of Molecular Medicine | 2012 |
Inhibition of hepatic sulfatase-2 In Vivo: A novel strategy to correct diabetic dyslipidemia
HC Hassing, H Mooij, S Guo, BP Monia, K Chen, W Kulik, GM Dallinga-Thie, M Nieuwdorp, ES Stroes, KJ Williams |
Hepatology | 2012 |
Arterial Retention of Remnant Lipoproteins Ex Vivo Is Increased in Insulin Resistance Because of Increased Arterial Biglycan and Production of Cholesterol‐Rich Atherogenic Particles That Can Be Improved by Ezetimibe in the JCR:LA‐ cp Rat
R Mangat, S Warnakula, F Borthwick, Z Hassanali, RR Uwiera, JC Russell, CI Cheeseman, DF Vine, SD Proctor |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2012 |
Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice
D Planer, S Metzger, E Zcharia, ID Wexler, I Vlodavsky, T Chajek-Shaul |
PloS one | 2011 |
Shedding of syndecan-1 from human hepatocytes alters VLDL clearance
Y Deng, EM Foley, JC Gonzales, PL Gordts, Y Li, JD Esko |
Hepatology | 2011 |
Brown adipose tissue activity controls triglyceride clearance
A Bartelt, OT Bruns, R Reimer, H Hohenberg, H Ittrich, K Peldschus, MG Kaul, UI Tromsdorf, H Weller, C Waurisch, A Eychmüller, PL Gordts, F Rinninger, K Bruegelmann, B Freund, P Nielsen, M Merkel, J Heeren |
Nature Medicine | 2011 |
Lipoprotein Lipase Inhibits Hepatitis C Virus (HCV) Infection by Blocking Virus Cell Entry
P Maillard, M Walic, P Meuleman, F Roohvand, T Huby, WL Goff, G Leroux-Roels, EI Pécheur, A Budkowska |
PloS one | 2011 |
An Essential Role for Diet in Exercise-Mediated Protection against Dyslipidemia, Inflammation and Atherosclerosis in ApoE-/- Mice
L Cesar, SV Suarez, J Adi, N Adi, R Vazquez-Padron, H Yu, Q Ma, PJ Goldschmidt-Clermont, A Agatston, P Kurlansky, KA Webster, GP Fadini |
PloS one | 2011 |
Globular warming: how fat gets to the furnace.
Williams KJ, Fisher EA |
Nature Medicine | 2011 |
Insulin-dependent diabetes mellitus in mice does not alter liver heparan sulfate
JR Bishop, E Foley, R Lawrence, JD Esko |
The Journal of biological chemistry | 2010 |
Type 2 Diabetes in Mice Induces Hepatic Overexpression of Sulfatase 2, a Novel Factor That Suppresses Uptake of Remnant Lipoproteins
K Chen, ML Liu, L Schaffer, M Li, G Boden, X Wu, KJ Williams |
Hepatology | 2010 |
Mechanisms of lipase maturation
MH Doolittle, M Péterfy |
Clinical Lipidology | 2010 |
Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer
I Kato, S Land, AP Majumdar, J Barnholtz-Sloan, RK Severson |
Cancer Epidemiology | 2010 |
Postprandial lipemia enhances the capacity of large HDL2 particles to mediate free cholesterol efflux via SR-BI and ABCG1 pathways in type IIB hyperlipidemia[S]
Z Julia, E Duchene, N Fournier, N Bellanger, MJ Chapman, WL Goff, M Guerin |
Journal of lipid research | 2010 |
Chylomicronemia With Low Postheparin Lipoprotein Lipase Levels in the Setting of GPIHBP1 Defects
R Franssen, SG Young, F Peelman, J Hertecant, JA Sierts, AW Schimmel, A Bensadoun, JJ Kastelein, LG Fong, GM Dallinga-Thie, AP Beigneux |
Circulation. Cardiovascular genetics | 2010 |
Syndecan-1, the Primary Heparan Sulfate Proteoglycan Mediating Hepatic Triglyceride-Rich Lipoprotein Clearance In Vivo
Kristin I. Stanford, Joseph R. Bishop, Erin M. Foley, Jon C. Gonzalez, Ingrid R. Niesman, Joseph L. Witztum, Jeffrey D. Esko |
Journal of Clinical Investigation | 2009 |
Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors
MJ Chapman, WL Goff, M Guerin, A Kontush |
European Heart Journal | 2009 |
Akt2 is required for hepatic lipid accumulation in models of insulin resistance
KF Leavens, RM Easton, GI Shulman, SF Previs, MJ Birnbaum |
Cell Metabolism | 2009 |
The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight
GM Dallinga-Thie, R Franssen, HL Mooij, ME Visser, HC Hassing, F Peelman, JJ Kastelein, M Péterfy, M Nieuwdorp |
Atherosclerosis | 2009 |
Triglycerides and cardiovascular risk
KE Harchaoui, ME Visser, JJ Kastelein, ES Stroes, GM Dallinga-Thie |
Current cardiology reviews | 2009 |
FoxO1 and hepatic lipid metabolism
JD Sparks, HH Dong |
Current Opinion in Lipidology | 2009 |
Triglycerides as vascular risk factors: new epidemiologic insights
WB Kannel, RS Vasan |
Current Opinion in Cardiology | 2009 |
Bringing retinoid metabolism into the 21st century
TJ van Berkel |
Journal of lipid research | 2009 |
Nitric oxide-releasing agent, LA419, reduces atherogenesis in apolipoprotein E-deficient mice
R Carnicer, N Guillén, JM Arbonés-Mainar, MA Navarro, MA Guzmán, C Barranquero, C Arnal, S Gascón, S Acín, M Mourelle, J Osada |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2008 |