Hepatic glucose sensing: does flux matter?

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Abstract

In this issue of the JCI, Denechaud et al. report studies investigating the role of the liver X receptors (LXRs) LXRα and LXRβ in carbohydrate sensing by the liver (see the related article beginning on page 956). The results of this study, which utilized LXRα/β double-KO mice, strongly contradict a recent Nature report that proposed that LXRα/β sense glucose independent of metabolic flux. The reported findings further support a key role for the carbohydrate-responsive element–binding protein (ChREBP) in the regulation of lipogenic genes by glucose and dietary carbohydrates.

Authors

Masakazu Shiota, Mark A. Magnuson