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Lisiane B. Meira, … , James G. Fox, Leona D. Samson
Published June 2, 2008
Citation Information: J Clin Invest. 2008;118(7):2516-2525. https://doi.org/10.1172/JCI35073.
Citation Information: J Clin Invest. 2008;118(7):2516-2525. https://doi.org/10.1172/JCI35073.
Abstract
Chronic inflammation increases cancer risk. While it is clear that cell signaling elicited by inflammatory cytokines promotes tumor development, the impact of DNA damage production resulting from inflammation-associated reactive oxygen and nitrogen species (RONS) on tumor development has not been directly tested. RONS induce DNA damage that can be recognized by alkyladenine DNA glycosylase (Aag) to initiate base excision repair. Using a mouse model of episodic inflammatory bowel disease by repeated administration of dextran sulfate sodium in the drinking water, we show that Aag-mediated DNA repair prevents colonic epithelial damage and reduces the severity of dextran sulfate sodium–induced colon tumorigenesis. Importantly, DNA base lesions expected to be induced by RONS and recognized by Aag accumulated to higher levels in Aag-deficient animals following stimulation of colonic inflammation. Finally, as a test of the generality of this effect we show that Aag-deficient animals display more severe gastric lesions that are precursors of gastric cancer after chronic infection with Helicobacter pylori. These data demonstrate that the repair of DNA lesions formed by RONS during chronic inflammation is important for protection against colon carcinogenesis.
Authors
Lisiane B. Meira, James M. Bugni, Stephanie L. Green, Chung-Wei Lee, Bo Pang, Diana Borenshtein, Barry H. Rickman, Arlin B. Rogers, Catherine A. Moroski-Erkul, Jose L. McFaline, David B. Schauer, Peter C. Dedon, James G. Fox, Leona D. Samson
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Citation information
Citations to this article (294)
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Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
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Journal of Clinical Medicine | 2019 |
|
Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2−/‐Il10−/−gpt delta mice is influenced by sex
Z Ge, Y Feng, A Sheh, S Muthupalani, G Gong, S Chawanthayatham, JM Essigmann, JG Fox |
International Journal of Cancer | 2019 |
|
The impact of gut microbiota manipulation with antibiotics on colon tumorigenesis in a murine model
JG Lee, CS Eun, SV Jo, A Lee, CH Park, DS Han, H Nakano |
PloS one | 2019 |
|
mTORC1 Prevents Epithelial Damage During Inflammation and Inhibits Colitis-Associated Colorectal Cancer Development
IZ Gutiérrez-Martínez, JF Rubio, ZL Piedra-Quintero, O Lopez-Mendez, C Serrano, E Reyes-Maldonado, C Salinas-Lara, A Betanzos, M Shibayama, A Silva-Olivares, A Candelario-Martinez, MA Meraz-Ríos, M Schnoor, N Villegas-Sepúlveda, P Nava |
Translational oncology | 2019 |
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A meta-analysis of the impact of neutrophil-to-lymphocyte ratio on treatment outcomes after radiotherapy for solid tumors:
N Choi, JH Kim, EK Chie, J Gim, HC Kang |
Medicine | 2019 |
|
Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention
Goh, Tan, Goh, Chan, Pusparajah, Lee, Goh |
Cancers | 2019 |
|
Aberrant DNA Polymerase Beta Enhances H. pylori Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice
S Zhao, M Thakur, AW Klattenhoff, D Kidane |
Cancers | 2019 |
|
Helicobacter pylori infection coexisting with intestinal metaplasia is not associated with colorectal neoplasms
B Boyuk, A Ozgur, H Atalay, A Celebi, I Ekizoglu, E Aykurt |
PRZ GASTROENTEROL | 2019 |
|
TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women
Włodarczyk M, Ciebiera M, Nowicka G |
Molecular Biology Reports | 2019 |
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Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation
Nakajima T, Vares G, Ninomiya Y, Wang B, Katsube T, Tanaka K, Maruyama K, Nenoi M |
Medical science monitor : international medical journal of experimental and clinical research | 2019 |
|
A Nontarget Mechanism to Explain Carcinogenesis Following α-Irradiation
Priest ND |
Dose-Response | 2019 |
|
Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis
Pakravan N, Kermanian F, Mahmoudi E |
Iranian Journal of Basic Medical Sciences | 2019 |
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Molecular Repolarisation of Tumour-Associated Macrophages
F van Dalen, M van Stevendaal, F Fennemann, M Verdoes, O Ilina |
Molecules (Basel, Switzerland) | 2018 |
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Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes
DB Graham, GJ Jasso, A Mok, G Goel, AC Ng, R Kolde, M Varma, JG Doench, DE Root, CB Clish, SA Carr, RJ Xavier |
Cell Reports | 2018 |
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Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis
A Vallée, Y Lecarpentier |
Frontiers in immunology | 2018 |
|
Neuroinflammation in Alzheimer’s disease: Pleiotropic roles for cytokines and neuronal pentraxins
A Swanson, T Wolf, A Sitzmann, AA Willette |
Behavioural Brain Research | 2018 |
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Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer
G Markopoulos, E Roupakia, M Tokamani, G Alabasi, R Sandaltzopoulos, K Marcu, E Kolettas |
Biomedicines | 2018 |
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Nitric oxide induced S-nitrosation causes base excision repair imbalance
MC Parrish, IA Chaim, ZD Nagel, SR Tannenbaum, LD Samson, BP Engelward |
DNA repair | 2018 |
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Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer
A Aponte-López, EM Fuentes-Pananá, D Cortes-Muñoz, S Muñoz-Cruz |
Journal of Immunology Research | 2018 |
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Incomplete base excision repair contributes to cell death from antibiotics and other stresses
CC Gruber, GC Walker |
DNA repair | 2018 |
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The controversial role of Enterococcus faecalis in colorectal cancer
CV de Almeida, A Taddei, A Amedei |
Therapeutic advances in gastroenterology | 2018 |
|
Molecular Mechanisms of H. pylori-Induced DNA Double-Strand Breaks
D Kidane |
International journal of molecular sciences | 2018 |
|
Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation
IC Chung, SN Yuan, CN OuYang, HC Lin, KY Huang, YJ Chen, AK Chung, CL Chu, DM Ojcius, YS Chang, LC Chen |
Cell Death and Disease | 2018 |
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Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model
N Hattori, T Niwa, T Ishida, K Kobayashi, T Imai, A Mori, K Kimura, T Mori, Y Asami, T Ushijima |
Cancer Science | 2018 |
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Effect of vitamin C on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated early colon cancer in mice
HJ Jeon, Y Yeom, YS Kim, E Kim, JH Shin, PR Seok, MJ Woo, Y Kim |
Nutrition Research and Practice | 2018 |
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MTG16 is a tumor suppressor in colitis-associated carcinoma
Elizabeth McDonough, Caitlyn Barrett, Bobak Parang, Mukul Mittal, J. Joshua Smith, Amber Bradley, Yash Choksi, Lori Coburn, Sarah Short, Joshua J. Thompson, baolin Zhang, Shenika Poindexter, Melissa A. Fischer, Xi Chen, Jiang Li, Frank Revetta, Rishi Naik, M. Kay Washington, Michael Rosen, Scott Hiebert, Keith T. Wilson, Christopher Williams |
JCI Insight | 2017 |
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PRL-3 promotes telomere deprotection and chromosomal instability
S Lian, L Meng, Y Yang, T Ma, X Xing, Q Feng, Q Song, C Liu, Z Tian, L Qu, C Shou |
Nucleic Acids Research | 2017 |
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MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells
C Botta, M Cucè, MR Pitari, D Caracciolo, A Gullà, E Morelli, C Riillo, L Biamonte, ME Cantafio, R Prabhala, C Mignogna, AD Vito, E Altomare, N Amodio, MT di Martino, P Correale, M Rossi, A Giordano, NC Munshi, P Tagliaferri, P Tassone |
Leukemia | 2017 |
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The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
JM García-Heredia, A Carnero |
Oncotarget | 2017 |
|
Açaí Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice
YJ Choi, YJ Choi, N Kim, RH Nam, S Lee, HS Lee, HN Lee, YJ Surh, DH Lee |
Gut and Liver | 2017 |
|
Inflammasomes in Inflammation-Induced Cancer
C Lin, J Zhang |
Frontiers in immunology | 2017 |
|
The Impact of Gut Microbiota on Gender-Specific Differences in Immunity
F Fransen, AA van Beek, T Borghuis, B Meijer, F Hugenholtz, CG der Jongh, HF Savelkoul, MI de Jonge, MM Faas, MV Boekschoten, H Smidt, SE Aidy, P Vos |
Frontiers in immunology | 2017 |
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Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer
J Ballista-Hernández, M Martínez-Ferrer, R Vélez, C Climent, MM Sánchez-Vázquez, C Torres, A Rodríguez-Muñoz, S Ayala-Peña, CA Torres-Ramos |
Molecular cancer research : MCR | 2017 |
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A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3, N 4 -ethenocytosine
IA Chaim, A Gardner, J Wu, T Iyama, DM Wilson, LD Samson |
Nucleic Acids Research | 2017 |
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Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation
EC Barker, BG Kim, JH Yoon, GP Tochtrop, JJ Letterio, SH Choi |
Carcinogenesis | 2017 |
|
Serum inflammatory markers and colorectal cancer risk and survival
S Ghuman, MV Hemelrijck, H Garmo, L Holmberg, H Malmström, M Lambe, N Hammar, G Walldius, I Jungner, W Wulaningsih |
British Journal of Cancer | 2017 |
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Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model
H Moulahoum, AL Nagy, B Djerdjouri, S Clichici |
Inflammopharmacology | 2017 |
|
Antibiotics ameliorate lupus-like symptoms in mice
Q Mu, VJ Tavella, JL Kirby, TE Cecere, M Chung, J Lee, S Li, SA Ahmed, K Eden, IC Allen, CM Reilly, XM Luo |
Scientific Reports | 2017 |
|
Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis
LD Butcher, G Hartog, PB Ernst, SE Crowe |
Cellular and Molecular Gastroenterology and Hepatology | 2017 |
|
Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk
DV Seidel, MA Azcárate-Peril, RS Chapkin, ND Turner |
Seminars in Cancer Biology | 2017 |
|
Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats
RF Abdel-Rahman, AF Hessin, M Abdelbaset, HA Ogaly, RM Abd-Elsalam, SM Hassan |
Oxidative medicine and cellular longevity | 2017 |
|
Polyphenols as Promising Drugs against Main Breast Cancer Signatures
M Losada-Echeberría, M Herranz-López, V Micol, E Barrajón-Catalán |
Antioxidants | 2017 |
|
Rethinking the bile acid/gut microbiome axis in cancer
JP Phelan, FJ Reen, JA Caparros-Martin, R OConnor, F OGara |
Oncotarget | 2017 |
|
Endosulfan induces apoptosis by activating the negative regulation pathway of cell cycle and death receptor pathway in spermatogenic cells
FZ Guo, Y Xu, LH Ren, J Zhang, F Zhang, J Duan, XQ Zhou, ZW Sun |
Toxicology Research | 2017 |
|
Xanthohumol prevents dextran sulfate sodium-induced colitis via inhibition of IKKβ/NF-κB signaling in mice
JM Cho, SM Yun, YH Choi, J Heo, NJ Kim, SH Kim, EH Kim |
Oncotarget | 2017 |
|
Inhibitory effects of vitamin E on osteocyte apoptosis and DNA oxidative damage in bone marrow hemopoietic cells at early stage of steroid-induced femoral head necrosis
YB Jia, DM Jiang, YZ Ren, ZH Liang, ZQ Zhao, YX Wang |
Molecular medicine reports | 2017 |
|
Microbiota, Inflammation and Colorectal Cancer
Lucas C, Barnich N, Nguyen HT |
International journal of molecular sciences | 2017 |
|
Base excision repair of oxidative DNA damage: from mechanism to disease.
Whitaker AM, Schaich MA, Smith MR, Flynn TS, Freudenthal BD |
2017 | |
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Melatonin as an anti-inflammatory agent in radiotherapy.
Najafi M, Shirazi A, Motevaseli E, Rezaeyan AH, Salajegheh A, Rezapoor S |
InflammoPharmacology | 2017 |
|
DNA Damage and Pulmonary Hypertension
B Ranchoux, J Meloche, R Paulin, O Boucherat, S Provencher, S Bonnet |
International journal of molecular sciences | 2016 |
|
Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche
H Ye, B Adane, N Khan, T Sullivan, M Minhajuddin, M Gasparetto, B Stevens, S Pei, M Balys, JM Ashton, DJ Klemm, CM Woolthuis, AW Stranahan, CY Park, CT Jordan |
Cell Stem Cell | 2016 |
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miR146a-mediated targeting of FANCM during inflammation compromises genome integrity
D Sundaravinayagam, HR Kim, TT Wu, HH Kim, HS Lee, S Jun, JH Cha, Y Kee, HJ You, JH Lee |
Oncotarget | 2016 |
|
Prolonged inflammatory microenvironment is crucial for pro-neoplastic growth and genome instability: a detailed review
K Anuja, S Roy, C Ghosh, P Gupta, S Bhattacharjee, B Banerjee |
Inflammation Research | 2016 |
|
Cancer and inflammation: Cancer and inflammation
LL Munn |
Wiley Interdisciplinary Reviews Systems Biology and Medicine | 2016 |
|
DNA Damage: From Chronic Inflammation to Age-Related Deterioration
A Ioannidou, E Goulielmaki, GA Garinis |
Frontiers in Genetics | 2016 |
|
Oxidative stress signaling to chromatin in health and disease
S Kreuz, W Fischle |
Epigenomics | 2016 |
|
The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury
AM Yu, JA Calvo, S Muthupalani, LD Samson |
Oncotarget | 2016 |
|
DNA Damage Response and Immune Defense: Links and Mechanisms
R Nakad, B Schumacher |
Frontiers in Genetics | 2016 |
|
Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer
D Ray, D Kidane |
Journal of Cancer | 2016 |
|
Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics
D Irimia, F Ellett |
Journal of leukocyte biology | 2016 |
|
Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils
Y Tanaka, S Ito, K Isobe |
Scientific Reports | 2016 |
|
From inflammation to cancer
A Korniluk, O Koper, H Kemona, V Dymicka-Piekarska |
Irish Journal of Medical Science | 2016 |
|
Spectrum of cancer risk among Taiwanese with chronic obstructive pulmonary disease.
Chiang CL, Hu YW, Wu CH, Chen YT, Liu CJ, Luo YH, Chen YM, Chen TJ, Su KC, Chou KT |
International Journal of Clinical Oncology | 2016 |
|
Endosulfan inhibiting the meiosis process via depressing expressions of regulatory factors and causing cell cycle arrest in spermatogenic cells.
Guo FZ, Zhang LS, Wei JL, Ren LH, Zhang J, Jing L, Yang M, Wang J, Sun ZW, Zhou XQ |
Environmental Science and Pollution Research | 2016 |
|
IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity
R Bahri, IS Pateras, O D’Orlando, DA Goyeneche-Patino, M Campbell, JK Polansky, H Sandig, M Papaioannou, K Evangelou, PG Foukas, VG Gorgoulis, S Bulfone-Paus |
OncoImmunology | 2015 |
|
Epigenetic regulation of DNA repair machinery in Helicobacter pylori -induced gastric carcinogenesis
JC Santos |
World journal of gastroenterology : WJG | 2015 |
|
Mechanisms of Immune Signaling in Colitis-Associated Cancer
MJ Waldner, MF Neurath |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2015 |
|
The effect of environmental chemicals on the tumor microenvironment
SC Casey, M Vaccari, F Al-Mulla, R Al-Temaimi, A Amedei, MH Barcellos-Hoff, DG Brown, M Chapellier, J Christopher, CS Curran, S Forte, RA Hamid, P Heneberg, DC Koch, PK Krishnakumar, E Laconi, V Maguer-Satta, F Marongiu, L Memeo, C Mondello, J Raju, J Roman, R Roy, EP Ryan, S Ryeom, HK Salem, AI Scovassi, N Singh, L Soucek, L Vermeulen, JR Whitfield, J Woodrick, AM Colacci, WH Bisson, DW Felsher |
Carcinogenesis | 2015 |
|
Influenza infection induces host DNA damage and dynamic DNA damage responses during tissue regeneration
N Li, M Parrish, TK Chan, L Yin, P Rai, Y Yoshiyuki, N Abolhassani, KB Tan, O Kiraly, VT Chow, BP Engelward |
Cellular and Molecular Life Sciences | 2015 |
|
The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis
F Grasso, SD Meo, GD Luca, L Pasquini, S Rossi, M Boirivant, M Biffoni, M Bignami, ED Carlo |
Oncotarget | 2015 |
|
Effect of MPG Gene rs2858056 Polymorphism, Copy Number Variation, and Level of Serum MPG Protein on the Risk for Rheumatoid Arthritis
CM Huang, SY Chen, PH Huang, FJ Tsai, K Roemer |
PloS one | 2015 |
|
The NLRP1 Inflammasome Attenuates Colitis and Colitis-Associated Tumorigenesis
TM Williams, RA Leeth, DE Rothschild, SL Coutermarsh-Ott, DK McDaniel, AE Simmons, B Heid, TE Cecere, IC Allen |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
|
Cytokine profile and prognostic significance of high neutrophil-lymphocyte ratio in colorectal cancer
ZY Chen, K Raghav, CH Lieu, ZQ Jiang, C Eng, JN Vauthey, GJ Chang, W Qiao, J Morris, D Hong, P Hoff, H Tran, DG Menter, J Heymach, M Overman, S Kopetz |
British Journal of Cancer | 2015 |
|
Impact of the immune system and immunotherapy in colorectal cancer
Janet L Markman, Stephen L Shiao |
Journal of Gastrointestinal Oncology | 2015 |
|
MUTYH Gene Polymorphisms as Risk Factors for Rheumatoid Arthritis
YJ Kung, KS Tsai, CM Huang, HJ Lin, TH Chen, YA Hsu, CY Chang, YS Huang, L Wan |
BioMed Research International | 2015 |
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Epigenetic Modifications and Accumulation of DNA Double-Strand Breaks in Oral Lichen Planus Lesions Presenting Poor Response to Therapy:
CS Dillenburg, MA Martins, LO Almeida, L Meurer, CH Squarize, MD Martins, RM Castilho |
Medicine | 2015 |
|
Id1 Deficiency Protects against Tumor Formation in ApcMin/+ Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer
N Zhang, K Subbaramaiah, RK Yantiss, XK Zhou, Y Chin, R Benezra, AJ Dannenberg |
Cancer prevention research (Philadelphia, Pa.) | 2015 |
|
Targeting the NFκB Signaling Pathways for Breast Cancer Prevention and Therapy
Wang W, Nag SA, Zhang R |
Current medicinal chemistry | 2015 |
|
Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner
Pathak S, Meng WJ, Nandy SK, Ping J, Bisgin A, Helmfors L, Waldmann P, Sun XF |
Oncotarget | 2015 |
|
Immune Chaperone gp96 Drives the Contributions of Macrophages to Inflammatory Colon Tumorigenesis
C Morales, S Rachidi, F Hong, S Sun, X Ouyang, C Wallace, Y Zhang, E Garret-Mayer, J Wu, B Liu, Z Li |
Cancer research | 2014 |
|
Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney
MR Ebrahimkhani, A Daneshmand, A Mazumder, M Allocca, JA Calvo, N Abolhassani, I Jhun, S Muthupalani, C Ayata, LD Samson |
Proceedings of the National Academy of Sciences | 2014 |
|
Interplay between DNA repair and inflammation, and the link to cancer
D Kidane, WJ Chae, J Czochor, KA Eckert, PM Glazer, AL Bothwell, JB Sweasy |
Critical Reviews in Biochemistry and Molecular Biology | 2014 |
|
Immune-epithelial crosstalk at the intestinal surface
N Wittkopf, MF Neurath, C Becker |
Journal of Gastroenterology | 2014 |
|
Inflammatory pathways in the early steps of colorectal cancer development
F Mariani, P Sena, L Roncucci |
World journal of gastroenterology : WJG | 2014 |
|
Molecular mechanisms of oncogene-induced inflammation and inflammation-sustained oncogene activation in gastrointestinal tumors: An underappreciated symbiotic relationship
D Dibra, L Mishra, S Li |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 |
|
Cancer: A Tale of Aberrant PRR Response
RS Nagi, AS Bhat, H Kumar |
Frontiers in immunology | 2014 |
|
Tumor Necrosis Factor- α -Induced Colitis Increases NADPH Oxidase 1 Expression, Oxidative Stress, and Neutrophil Recruitment in the Colon: Preventive Effect of Apocynin
S Mouzaoui, B Djerdjouri, N Makhezer, Y Kroviarski, J El-Benna, PM Dang |
Mediators of Inflammation | 2014 |
|
Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota
MT Whary, S Muthupalani, Z Ge, Y Feng, J Lofgren, HN Shi, NS Taylor, P Correa, J Versalovic, TC Wang, JG Fox |
Microbes and Infection | 2014 |
|
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
S Rutz, X Wang, W Ouyang |
Nature Reviews Immunology | 2014 |
|
Caspase-11 attenuates gastrointestinal inflammation and experimental colitis pathogenesis
TM Williams, RA Leeth, DE Rothschild, DK McDaniel, SL Coutermarsh-Ott, AE Simmons, KH Kable, B Heid, IC Allen |
AJP Gastrointestinal and Liver Physiology | 2014 |
|
Slow repair of lipid peroxidation-induced DNA damage at p53 mutation hotspots in human cells caused by low turnover of a DNA glycosylase
J Woodrick, S Gupta, P Khatkar, S Sarangi, G Narasimhan, A Trehan, S Adhikari, R Roy |
Nucleic Acids Research | 2014 |
|
Base excision repair capacity in informing healthspan
BM Brenerman, JL Illuzzi, DM Wilson |
Carcinogenesis | 2014 |
|
Repair of endogenous DNA base lesions modulate lifespan in mice
LB Meira, JA Calvo, D Shah, J Klapacz, CA Moroski-Erkul, RT Bronson, LD Samson |
DNA repair | 2014 |
|
At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer
DM Hardbower, RM Peek, KT Wilson |
Journal of leukocyte biology | 2014 |
|
Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans
H Brim, M Zahaf, AO Laiyemo, M Nouraie, GI Pérez-Pérez, DT Smoot, E Lee, H Razjouyan, H Ashktorab |
BMC Cancer | 2014 |
|
Helicobacter pylori and gastric cancer: Indian enigma
V Misra, R Pandey, SP Misra, M Dwivedi |
World journal of gastroenterology : WJG | 2014 |
|
Impaired Self-Renewal and Increased Colitis and Dysplastic Lesions in Colonic Mucosa of AKR1B8 Deficient Mice
Y Shen, J Ma, R Yan, H Ling, X Li, W Yang, J Gao, C Huang, Y Bu, Y Cao, Y He, L Wan, X Zu, HJ Liu, MC Huang, WF Stenson, DF Liao, D Cao |
2014 | |
|
Targeting chemokine pathways in esophageal adenocarcinoma
MS Shrivastava, Z Hussain, O Giricz, N Shenoy, R Polineni, A Maitra, A Verma |
Cell cycle (Georgetown, Tex.) | 2014 |
|
Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection
D Kidane, DL Murphy, JB Sweasy |
Oncogenesis | 2014 |
|
Structural Basis for Promutagenicity of 8-Halogenated Guanine
MC Koag, K Min, S Lee |
The Journal of biological chemistry | 2014 |
|
The gastrointestinal microbiota and colorectal cancer
TO Keku, S Dulal, A Deveaux, B Jovov, X Han |
AJP Gastrointestinal and Liver Physiology | 2014 |
|
Germ Line Variants of Human N -Methylpurine DNA Glycosylase Show Impaired DNA Repair Activity and Facilitate 1, N 6 -Ethenoadenine-induced Mutations
S Adhikari, MA Chetram, J Woodrick, PS Mitra, PV Manthena, P Khatkar, S Dakshanamurthy, M Dixon, SK Karmahapatra, NK Nuthalapati, S Gupta, G Narasimhan, R Mazumder, CA Loffredo, A Üren, R Roy |
The Journal of biological chemistry | 2014 |
|
A Peripheral Circulating TH1 Cytokine Profile Is Inversely Associated with Prostate Cancer Risk in CLUE II
NA Bhavsar, JH Bream, AK Meeker, CG Drake, SB Peskoe, D Dabitao, AM de Marzo, WB Isaacs, EA Platz |
Cancer epidemiology, biomarkers & prevention | 2014 |
|
Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis
Lin R, Xiao D, Guo Y, Tian D, Yun H, Chen D, Su M |
Oncotarget | 2014 |
|
Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasias through ERK
Clemens Neufert, Christoph Becker, Oezlem Tuereci, Maximilian J Waldner, Ingo Backert, Katharina Floh, Imke Atreya, Moritz Leppkes, Andre Jefremow, Michael Vieth, Regine Schneider-Stock, Patricia Klinger, Florian Greten, David Threadgill, Ugur Sahin, Markus F. Neurath |
Journal of Clinical Investigation | 2013 |
|
Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling
BR Achyut, DA Bader, AI Robles, D Wangsa, CC Harris, T Ried, L Yang |
PLoS genetics | 2013 |
|
Chemistry meets biology in colitis-associated carcinogenesis
A Mangerich, PC Dedon, JG Fox, SR Tannenbaum, GN Wogan |
Free Radical Research | 2013 |
|
Base Excision Repair
HE Krokan, M Bjoras |
Cold Spring Harbor perspectives in biology | 2013 |
|
INFLAMMATORY BOWEL DISEASE: MECHANISMS, REDOX CONSIDERATIONS AND THERAPEUTIC TARGETS
F Biasi, G Leonarduzzi, PI Oteiza, G Poli |
Antioxidants & Redox Signaling | 2013 |
|
Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly
P Serafini |
Immunologic Research | 2013 |
|
Alterations in macrophages and monocytes from tumor-bearing mice: evidence of local and systemic immune impairment
M Torroella-Kouri, D Rodríguez, R Caso |
Immunologic Research | 2013 |
|
Tumor microenvironment profoundly modifies functional status of macrophages: Peritoneal and tumor-associated macrophages are two very different subpopulations
D Rodríguez, R Silvera, R Carrio, M Nadji, R Caso, G Rodríguez, V Iragavarapu-Charyulu, M Torroella-Kouri |
Cellular Immunology | 2013 |
|
Repeated H 2 O 2 exposure drives cell cycle progression in an in vitro model of ulcerative colitis
A Poehlmann, K Reissig, P Schönfeld, D Walluscheck, A Schinlauer, R Hartig, W Lessel, T Guenther, A Silver, A Roessner |
Journal of Cellular and Molecular Medicine | 2013 |
|
p120catenin alteration in cancer and its role in tumour invasion
F Peglion, S Etienne-Manneville |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2013 |
|
Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
SN Mowla, ND Perkins, PS Jat |
OncoTargets and therapy | 2013 |
|
Micro-RNAs in inflammatory diseases and as a link between inflammation and cancer
R Ranjha, J Paul |
Inflammation Research | 2013 |
|
Chronic inflammation and oxidative stress: The smoking gun for Helicobacter pylori-induced gastric cancer?
DM Hardbower, T Sablet, R Chaturvedi, KT Wilson |
Gut microbes | 2013 |
|
Impact of interleukin-10 gene polymorphisms on survival in patients with colorectal cancer
WC Ting, LM Chen, LC Huang, MJ Hour, YH Lan, HZ Lee, BJ You, TY Chang, BY Bao |
Journal of Korean Medical Science | 2013 |
|
Elevated incidence of polyp formation in APC(Min/⁺)Msh2⁻/⁻ mice is independent of nitric oxide-induced DNA mutations
A Belcheva, B Green, A Weiss, C Streutker, A Martin |
PloS one | 2013 |
|
Application of liposomes in drug development--focus on gastroenterological targets
JX Zhang, K Wang, ZF Mao, X Fan, DL Jiang, M Chen, L Cui, K Sun, SC Dang |
International Journal of Nanomedicine | 2013 |
|
Cancer heterogeneity--a multifaceted view
FD Melo, L Vermeulen, E Fessler, JP Medema |
EMBO reports | 2013 |
|
Monocytes mediate metastatic breast tumor cell adhesion to endothelium under flow
SJ Evani, RG Prabhu, V Gnanaruban, EA Finol, AK Ramasubramanian |
The FASEB Journal | 2013 |
|
Chemoprevention of Gastrointestinal Cancer: The Reality and the Dream
KS Chun, EH Kim, S Lee, KB Hahm |
Gut and Liver | 2013 |
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Ets1 and heat shock factor 1 regulate transcription of the Transformer 2β gene in human colon cancer cells.
Kajita K, Kuwano Y, Kitamura N, Satake Y, Nishida K, Kurokawa K, Akaike Y, Honda M, Masuda K, Rokutan K |
Journal of Gastroenterology | 2013 |
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DNA repair is indispensable for survival after acute inflammation in mice
Jennifer Calvo, Lisiane Meira, Chun-Yue Lee, Catherine Moroski-Erkul, Nona Abolhassani, Koli Taghizadeh, Lindsey Eichinger, Sureshkumar Muthupalani, Line Nordstrand, Arne Klungland, Leona Samson |
Journal of Clinical Investigation | 2012 |
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Balancing repair and tolerance of DNA damage caused by alkylating agents
D Fu, JA Calvo, LD Samson |
Nature Reviews Cancer | 2012 |
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Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer
DC Rubin, A Shaker, MS Levin |
Frontiers in immunology | 2012 |
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Inflammation and colorectal cancer: colitis-associated neoplasia
SI Grivennikov |
Seminars in Immunopathology | 2012 |
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Monocytes and Macrophages in Cancer: Development and Functions
DM Richards, J Hettinger, M Feuerer |
Cancer Microenvironment | 2012 |
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NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling
IC Allen, JE Wilson, M Schneider, JD Lich, RA Roberts, JC Arthur, RM Woodford, BK Davis, JM Uronis, HH Herfarth, C Jobin, AB Rogers, JP Ting |
Immunity | 2012 |
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Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells
AP Gobert, T Verriere, T Sablet, RM Peek, R Chaturvedi, KT Wilson |
Cellular Microbiology | 2012 |
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Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation
H Shaked, LJ Hofseth, A Chumanevich, AA Chumanevich, J Wang, Y Wang, K Taniguchi, M Guma, S Shenouda, H Clevers, CC Harris, M Karin |
Proceedings of the National Academy of Sciences | 2012 |
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Chronic Helicobacter pylori Infection and DNA-Damaged Stem Cells: A Recipe for Disaster
RM Peek |
Digestive Diseases and Sciences | 2012 |
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Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway
T Wang, X Wang, J Xu, XP Wu, H Qiu, H Yi, WX Li |
Journal of Cellular and Molecular Medicine | 2012 |
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Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats
EA Rondini, MR Bennink |
Journal of nutrition and metabolism | 2012 |
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Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians
MA Mustapha, SN Shahpudin, AA Aziz, R Ankathil |
World journal of gastroenterology : WJG | 2012 |
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Gastric-to-intestinal transdifferentiation and cancer
JM Noto, RM Peek |
Proceedings of the National Academy of Sciences | 2012 |
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Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
SI Grivennikov, K Wang, D Mucida, CA Stewart, B Schnabl, D Jauch, K Taniguchi, GY Yu, CH Osterreicher, KE Hung, C Datz, Y Feng, ER Fearon, M Oukka, L Tessarollo, V Coppola, F Yarovinsky, H Cheroutre, L Eckmann, G Trinchieri, M Karin |
Nature | 2012 |
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Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer
A Mangerich, CG Knutson, NM Parry, S Muthupalani, W Ye, E Prestwich, L Cui, JL McFaline, M Mobley, Z Ge, K Taghizadeh, JS Wishnok, GN Wogan, JG Fox, SR Tannenbaum, PC Dedon |
Proceedings of the National Academy of Sciences | 2012 |
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Base excision repair and cancer
SS Wallace, DL Murphy, JB Sweasy |
Cancer Letters | 2012 |
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Infection, inflammation and colon carcinogenesis
Wogan GN, Dedon PC, Tannenbaum SR, Fox JG |
Oncotarget | 2012 |
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[Pathogenesis of colitis-associated neoplasms].
Vieth M, Neumann H |
Der Pathologe | 2012 |
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Intestinal inflammation and colorectal cancer: A double-edged sword?
A Rizzo, F Pallone, G Monteleone, MC Fantini |
World journal of gastroenterology : WJG | 2011 |
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Role of TLR2-dependent inflammation in metastatic progression
S Kim, M Karin |
Annals of the New York Academy of Sciences | 2011 |
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Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells
IM Toller, KJ Neelsen, M Steger, ML Hartung, MO Hottiger, M Stucki, B Kalali, M Gerhard, AA Sartori, M Lopes, A Müller |
Proceedings of the National Academy of Sciences | 2011 |
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The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies
MD Robertis, E Massi, ML Poeta, S Carotti, S Morini, L Cecchetelli, E Signori, VM Fazio |
Journal of carcinogenesis | 2011 |
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Immune Evasion by Helicobacter pylori Is Mediated by Induction of Macrophage Arginase II
ND Lewis, M Asim, DP Barry, T de Sablet, K Singh, MB Piazuelo, AP Gobert, R Chaturvedi, KT Wilson |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
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Adenoma formation following limited ablation of p120-catenin in the mouse intestine
WG Smalley-Freed, A Efimov, SP Short, P Jia, Z Zhao, MK Washington, S Robine, RJ Coffey, AB Reynolds |
PloS one | 2011 |
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Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis
R Chaturvedi, T Sablet, LA Coburn, AP Gobert, KT Wilson |
Amino Acids | 2011 |
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Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase
JW Setser, GM Lingaraju, CA Davis, LD Samson, CL Drennan |
Biochemistry | 2011 |
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Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion
VK Batra, DD Shock, WA Beard, CE McKenna, SH Wilson |
Proceedings of the National Academy of Sciences | 2011 |
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Origins of injection-site sarcomas in cats: the possible role of chronic inflammation-a review
KN Woodward |
ISRN Veterinary Science | 2011 |
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Array-based identification of common DNA methylation alterations in ulcerative colitis
K Koizumi, S Alonso, Y Miyaki, S Okada, H Ogura, N Shiiya, F Konishi, T Taya, M Perucho, K Suzuki |
International journal of oncology | 2011 |
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Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase
D Fu, LD Samson |
DNA repair | 2011 |
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XRCC1 and base excision repair balance in response to nitric oxide
JT Mutamba, D Svilar, S Prasongtanakij, XH Wang, YC Lin, PC Dedon, RW Sobol, BP Engelward |
DNA repair | 2011 |
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The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer
JM Bugni, LA Rabadi, K Jubbal, I Karagiannides, G Lawson, C Pothoulakis |
International Journal of Cancer | 2011 |
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Association of the C-285T and A5954G polymorphisms in the DNA repair gene OGG1 with the susceptibility of rheumatoid arthritis.
Chen SY, Wan L, Huang CM, Huang YC, Sheu JJ, Lin YJ, Liu SP, Lan YC, Lai CH, Lin CW, Tsai CH, Tsai FJ |
Rheumatology International | 2011 |
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Rheumatoid arthritis risk associates with DNA repair gene XRCC1 Arg399Gln polymorphism in Turkish patients.
Yosunkaya E, Karakurt F, Cetin E, Ozgonenel L, Onaran I, Batar B, Guven M, Sultuybek GK |
Rheumatology International | 2011 |
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Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models
AM Westbrook, A Szakmary, RH Schiestl |
Mutation research | 2010 |
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Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
M Erreni, A Mantovani, P Allavena |
Cancer Microenvironment | 2010 |
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Oxidative stress, inflammation, and cancer: How are they linked?
S Reuter, SC Gupta, MM Chaturvedi, BB Aggarwal |
Free radical biology & medicine | 2010 |
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Macrophage Diversity Enhances Tumor Progression and Metastasis
BZ Qian, JW Pollard |
Cell | 2010 |
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Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection
A Sheh, CW Lee, K Masumura, BH Rickman, T Nohmi, GN Wogan, JG Fox, DB Schauer |
Proceedings of the National Academy of Sciences | 2010 |
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Immunity, Inflammation, and Cancer
SI Grivennikov, FR Greten, M Karin |
Cell | 2010 |
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Cell resilience in species life spans: a link to inflammation?
CE Finch, TE Morgan, VD Longo, JP de Magalhaes |
Aging Cell | 2010 |
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Pathobiology of the neutrophil-intestinal epithelial cell interaction: role in carcinogenesis
PM Hofman |
World journal of gastroenterology : WJG | 2010 |
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Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression
TO Ishikawa, HR Herschman |
Carcinogenesis | 2010 |
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Inflammation and oncogenesis: a vicious connection
SI Grivennikov, M Karin |
Current Opinion in Genetics & Development | 2010 |
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Helicobacter pylori: gastric cancer and beyond
DB Polk, RM Peek |
Nature reviews. Cancer | 2010 |
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Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis
S Wirtz, G Nagel, L Eshkind, MF Neurath, LD Samson, B Kaina |
Carcinogenesis | 2010 |
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The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis
I Casorelli, T Pannellini, GD Luca, P Degan, F Chiera, I Iavarone, A Giuliani, A Butera, M Boirivant, P Musiani, M Bignami |
PloS one | 2010 |
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Compound K, a Metabolite of Ginseng Saponin, Induces Mitochondria-Dependent and Caspase-Dependent Apoptosis via the Generation of Reactive Oxygen Species in Human Colon Cancer Cells
IK Lee, KA Kang, CM Lim, KC Kim, HS Kim, DH Kim, BJ Kim, WY Chang, JH Choi, JW Hyun |
International journal of molecular sciences | 2010 |
|
Formation and repair of tobacco carcinogen-derived bulky DNA adducts
B Hang |
Journal of nucleic acids | 2010 |
|
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
IC Allen, EM TeKippe, RM Woodford, JM Uronis, EK Holl, AB Rogers, HH Herfarth, C Jobin, JP Ting |
Journal of Experimental Medicine | 2010 |
|
Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation
AM Westbrook, RH Schiestl |
Cancer research | 2010 |
|
The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies
Prindle MJ, Fox EJ, Loeb LA |
Current drug targets | 2010 |
|
The TEL-AML1 leukaemia fusion gene dysregulates the TGF beta pathway in early B lineage progenitor cells
Anthony FORD, Chiara PALMI, Clara BUENO, Dengli HONG, Penny CARDUS, Deborah KNIGHT, Giovanni CAZZANIGA, Tariq ENVER, Mel GREAVES |
Journal of Clinical Investigation | 2009 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Decreased Expression of Colonic Slc26a3 and Carbonic Anhydrase IV as a Cause of Fatal Infectious Diarrhea in Mice
D Borenshtein, KA Schlieper, BH Rickman, JM Chapman, CW Schweinfest, JG Fox, DB Schauer |
Infection and immunity | 2009 |
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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
S Grivennikov, E Karin, J Terzic, D Mucida, GY Yu, S Vallabhapurapu, J Scheller, S Rose-John, H Cheroutre, L Eckmann, M Karin |
Cancer Cell | 2009 |
|
Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
AJ Schetter, NH Heegaard, CC Harris |
Carcinogenesis | 2009 |
|
Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells
WS Garrett, S Punit, CA Gallini, M Michaud, D Zhang, KS Sigrist, GM Lord, JN Glickman, LH Glimcher |
Cancer Cell | 2009 |
|
Intestinal mucosal inflammation leads to systemic genotoxicity in mice
AM Westbrook, B Wei, J Braun, RH Schiestl |
Cancer research | 2009 |
|
Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase
LE Jones, L Ying, AB Hofseth, E Jelezcova, RW Sobol, S Ambs, CC Harris, MG Espey, LJ Hofseth, MD Wyatt |
Carcinogenesis | 2009 |
|
Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice
LB Meira, CA Moroski-Erkul, SL Green, JA Calvo, RT Bronson, D Shah, LD Samson |
Proceedings of the National Academy of Sciences | 2009 |
|
RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects
PK Kreeger, R Mandhana, SK Alford, KM Haigis, DA Lauffenburger |
Cancer research | 2009 |
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Oxidation and glycolytic cleavage of etheno and propano DNA base adducts
CG Knutson, EH Rubinson, D Akingbade, CS Anderson, DF Stec, KV Petrova, ID Kozekov, FP Guengerich, CJ Rizzo, LJ Marnett |
Biochemistry | 2009 |
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Impact of Conformational Heterogeneity of OxoG Lesions and Their Pairing Partners on Bypass Fidelity by Y Family Polymerases
O Rechkoblit, L Malinina, Y Cheng, NE Geacintov, S Broyde, DJ Patel |
Structure | 2009 |
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PUMA Kills Stem Cells to Stall Cancer?
Yu J |
Molecular and cellular pharmacology | 2009 |
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More damaging than we think: Systemic effects of intestinal inflammation
Westbrook AM, Wei B, Braun J, Schiestl RH |
Cell cycle (Georgetown, Tex.) | 2009 |
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Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer.
Feagins LA, Souza RF, Spechler SJ |
Nature reviews. Gastroenterology & hepatology | 2009 |
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Mutant mouse models of oxidative stress.
Pouyet L, Carrier A |
Transgenic Research | 2009 |
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