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Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

E Gazzerro, … , V Gangji, E Canalis

E Gazzerro, … , V Gangji, E Canalis

Published December 15, 1998
Citation Information: J Clin Invest. 1998;102(12):2106-2114. https://doi.org/10.1172/JCI3459.

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Affinity-selected heparan sulfate for bone repair S Murali, B Rai, C Dombrowski, JL Lee, ZX Lim, DS Bramono, L Ling, T Bell, S Hinkley, SS Nathan, JH Hui, HK Wong, V Nurcombe, SM Cool	Biomaterials	2013
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Identification of NOG as a Specific Breast Cancer Bone Metastasis-supporting Gene M Tarragona, M Pavlovic, A Arnal-Estapé, J Urosevic, M Morales, M Guiu, E Planet, E González-Suárez, RR Gomis	The Journal of biological chemistry	2012
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PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs AI Caplan, D Correa	Journal of Orthopaedic Research	2011
Osteoinductivity of partially purified bovine, ostrich and emu bone morphogenetic proteins in vitro ZM Hu, SA Peel, TC Lindholm, GK Sàndor, CM Clokie, Y Su	Journal of Biomedical Materials Research Part A	2011
Gremlin1 is required for skeletal development and postnatal skeletal homeostasis E Canalis, K Parker, S Zanotti	Journal of Cellular Physiology	2011
Bone morphogenetic protein 4 (BMP4) is required for migration and invasion of breast cancer D Guo, J Huang, J Gong	Molecular and Cellular Biochemistry	2011
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Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation T Manaka, A Suzuki, K Takayama, Y Imai, H Nakamura, K Takaoka	Biomaterials	2011
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Superior Osteogenic Capacity of Human Embryonic Stem Cells Adapted to Matrix-Free Growth Compared to Human Mesenchymal Stem Cells N Bigdeli, GM de Peppo, M Lennerås, P Sjövall, A Lindahl, J Hyllner, C Karlsson	Tissue Engineering Part A	2010
Fundamentals of Osteoporosis AM Parfitt	Fundamentals of Osteoporosis	2010
Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity K Song, C Krause, S Shi, M Patterson, R Suto, L Grgurevic, S Vukicevic, M Dinther, D Falb, P Dijke, MH Alaoui-Ismaili	The Journal of biological chemistry	2010
Soluble and insoluble signals sculpt osteogenesis in angiogenesis U Ripamonti	World journal of biological chemistry	2010
Induction of bone formation by transforming growth factor-β2 in the non-human primate Papio ursinus and its modulation by skeletal muscle responding stem cells: Induction of bone formation by TGF-β2 U Ripamonti, LC Roden	Cell Proliferation	2010
Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN P Seemann, A Brehm, J König, C Reissner, S Stricker, P Kuss, J Haupt, S Renninger, J Nickel, W Sebald, JC Groppe, F Plöger, J Pohl, MS Kegler, M Walther, I Gassner, C Rusu, AR Janecke, K Dathe, S Mundlos	PLoS genetics	2009
ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events K Miyai, M Yoneda, U Hasegawa, S Toita, Y Izu, H Hemmi, T Hayata, Y Ezura, S Mizutani, K Miyazono, K Akiyoshi, T Yamamoto, M Noda	The Journal of biological chemistry	2009
RNA interference for noggin enhances the biological activity of bone morphogenetic proteins in vivo and in vitro K Takayama, A Suzuki, T Manaka, S Taguchi, Y Hashimoto, Y Imai, S Wakitani, K Takaoka	Journal of Bone and Mineral Metabolism	2009
When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols A Trzeciakiewicz, V Habauzit, MN Horcajada	Nutrition Research Reviews	2009
New insights into BMP-7 mediated osteoblastic differentiation of primary human mesenchymal stem cells K Lavery, S Hawley, P Swain, R Rooney, D Falb, MH Alaoui-Ismaili	Bone	2009
Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease K Hara, A Shiga, T Fukutake, H Nozaki, A Miyashita, A Yokoseki, H Kawata, A Koyama, K Arima, T Takahashi, M Ikeda, H Shiota, M Tamura, Y Shimoe, M Hirayama, T Arisato, S Yanagawa, A Tanaka, I Nakano, S Ikeda, Y Yoshida, T Yamamoto, T Ikeuchi, R Kuwano, M Nishizawa, S Tsuji, O Onodera	New England Journal of Medicine	2009
Design of second generation therapeutic recombinant bone morphogenetic proteins MH Alaoui-Ismaili, D Falb	Cytokine & Growth Factor Reviews	2009
Deletion of BMP7 affects the development of bones, teeth, and other ectodermal appendages of the orofacial complex V Zouvelou, HU Luder, TA Mitsiadis, D Graf	Journal of Experimental Zoology Part B: Molecular and Developmental Evolution	2009
Modulation of bone morphogenetic protein antagonists to stimulate clinical osteogenesis J Ahn, DJ de Gorter, M Prasarn, DL Helfet, P Kloen	Bioscience hypotheses	2009
ANA Deficiency Enhances Bone Morphogenetic Protein-induced Ectopic Bone Formation via Transcriptional Events K Miyai, M Yoneda, U Hasegawa, S Toita, Y Izu, H Hemmi, T Hayata, Y Ezura, S Mizutani, K Miyazono, K Akiyoshi, T Yamamoto, M Noda	The Journal of biological chemistry	2009
Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis M Scheideler, C Elabd, LE Zaragosi, C Chiellini, H Hackl, F Sanchez-Cabo, S Yadav, K Duszka, G Friedl, C Papak, A Prokesch, R Windhager, G Ailhaud, C Dani, EZ Amri, Z Trajanoski	BMC Genomics	2008
Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells FN Kwong, SM Richardson, CH Evans	Arthritis Research & Therapy	2008
Biological Basis of Bone Formation, Remodeling, and Repair—Part I: Biochemical Signaling Molecules AC Allori, AM Sailon, SM Warren	Tissue Engineering Part B: Reviews	2008
The induction of endochondral bone formation by transforming growth factor-β3: experimental studies in the non-human primate Papio ursinus U Ripamonti, LN Ramoshebi, J Teare, L Renton, C Ferretti	Journal of Cellular and Molecular Medicine	2008
Short-Term Effects of rhBMP-2–Enhanced Bone Augmentation Beyond the Skeletal Envelope Within a Titanium Cap in Rabbit Calvarium Y Hasegawa, S Sato, T Takayama, M Murai, N Suzuki, K Ito	Journal of Periodontology	2008
The prognostic significance of BMP-6 signaling in prostate cancer HF Yuen, YP Chan, WL Cheung, YC Wong, X Wang, KW Chan	Modern Pathology	2008
Effect of safflower seeds supplementation on stimulation of the proliferation, differentiation and mineralization of osteoblastic MC3T3-E1 cells KW Kim, SJ Suh, TK Lee, KT Ha, JK Kim, KH Kim, DI Kim, JH Jeon, TC Moon, CH Kim	Journal of Ethnopharmacology	2008
BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells*S⃞ K Lavery, P Swain, D Falb, MH Alaoui-Ismaili	The Journal of biological chemistry	2008
Principles of Bone Biology CJ Rosen, T Niu	Principles of Bone Biology	2008
BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells K Lavery, P Swain, D Falb, MH Alaoui-Ismaili	The Journal of biological chemistry	2008
Bone Morphogenetic Proteins: From Local to Systemic Therapeutics S Vukicevic, KT Sampath		2008
Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases R Schwaninger, CA Rentsch, A Wetterwald, G der Horst, RL van Bezooijen, G der Pluijm, CW Löwik, K Ackermann, W Pyerin, FC Hamdy, GN Thalmann, MG Cecchini	The American Journal of Pathology	2007
TGF-β signaling is essential for joint morphogenesis A Spagnoli, L O'Rear, RL Chandler, F Granero-Molto, DP Mortlock, AE Gorska, JA Weis, L Longobardi, A Chytil, K Shimer, HL Moses	The Journal of Cell Biology	2007
Transcriptomic and phenotypic analysis of murine embryonic stem cell derived BMP2+ lineage cells: an insight into mesodermal patterning MX Doss, S Chen, J Winkler, R Hippler-Altenburg, M Odenthal, C Wickenhauser, S Balaraman, H Schulz, O Hummel, N Hübner, N Ghosh-Choudhury, I Sotiriadou, J Hescheler, A Sachinidis	Genome biology	2007
Evidence for expansion-based temporal BMP4/NOGGIN interactions in specifying periodontium morphogenesis JY Kim, SW Cho, HJ Hwang, MJ Lee, JM Lee, J Cai, SH Choi, CK Kim, HS Jung	Cell and Tissue Research	2007
Endogenous Bone Morphogenetic Protein-7 Controls the Motility of Prostate Cancer Cells Through Regulation of Bone Morphogenetic Protein Antagonists L Ye, JM Lewis-Russell, H Kynaston, WG Jiang	The Journal of Urology	2007
Expression of Indian Hedgehog, BMP-4 and Noggin in Craniosynostosis Induced by Fetal Constraint S Jacob, C Wu, TA Freeman, E Koyama, RE Kirschner	Annals of Plastic Surgery	2007
Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells EA Sivertsen, K Huse, ME Hystad, C Kersten, EB Smeland, JH Myklebust	European Journal of Immunology	2007
Bone Matrix Formation in Osteogenic Cultures Derived from Human Embryonic Stem Cells In Vitro E Kärner, C Unger, AJ Sloan, L Ährlund-Richter, RV Sugars, M Wendel	Stem Cells and Development	2007
Dual effect of adenovirus-mediated transfer of BMP7 in mixed neuron-glial cultures: Neuroprotection and cellular differentiation MJ Tsai, CF Weng, SK Shyue, DY Liou, CH Chen, CW Chiu, TH Yang, HA Pan, RI Liao, HS Kuo, MC Huang, WC Huang, BJ Hoffer, H Cheng	Journal of Neuroscience Research	2007
Changes in extracellular activin A:follistatin ratio during differentiation of a mesenchymal progenitor cell line, ROB-C26 into osteoblasts and adipocytes N Kawabata, N Kamiya, N Suzuki, M Matsumoto, M Takagi	Life Sciences	2007
A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo DW Hampton, RA Asher, T Kondo, JD Steeves, MS Ramer, JW Fawcett	European Journal of Neuroscience	2007
Molecular aspects of fracture healing:Which are the important molecules? E Tsiridis, N Upadhyay, P Giannoudis	Injury	2007
Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of β-catenin in proliferation and differentiation B Liu, HM Yu, W Hsu	Developmental Biology	2007
Bone Morphogenetic Proteins-Signaling Plays a Role in Tendon-to-Bone Healing CB Ma, S Kawamura, XH Deng, L Ying, J Schneidkraut, P Hays, SA Rodeo	The American journal of sports medicine	2007
Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans CH Hwang, DK Wu	Human Molecular Genetics	2007
The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts D Peiris, I Pacheco, C Spencer, RJ MacLeod	AJP Gastrointestinal and Liver Physiology	2007
Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro W Zhu, J Kim, C Cheng, BA Rawlins, O Boachie-Adjei, RG Crystal, C Hidaka	Bone	2006
Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation B Liu, HM Yu, W Hsu	Developmental Biology	2006
Bone morphogenetic proteins and their antagonists E Gazzerro, E Canalis	Reviews in Endocrine and Metabolic Disorders	2006
EFFECTS OF ULMUS DAVIDIANA PLANCH ON MINERALIZATION, BONE MORPHOGENETIC PROTEIN-2, ALKALINE PHOSPHATASE, TYPE I COLLAGEN, AND COLLAGENASE-1 IN BONE CELLS SK Kang, KS Kim, YS Byun, SJ Suh, UH Jim, KH Kim, IS Lee, CH Kim	In Vitro Cellular & Developmental Biology - Animal	2006
Up-regulation of bone morphogenetic protein receptor IB by growth factors enhances BMP-2-induced human bone cell functions W Singhatanadgit, V Salih, I Olsen	Journal of Cellular Physiology	2006
The role of inhibitory molecules in fracture healing R Dimitriou, E Tsiridis, I Carr, H Simpson, PV Giannoudis	Injury	2006
Coordinate expression of BMP-2, BMP receptors and Noggin in normal mouse spine Y Nakamura, H Nakaya, N Saito, S Wakitani	Journal of Clinical Neuroscience	2006
Dysregulation of the BMP-4 Signaling Pathway in Fibrodysplasia Ossificans Progressiva FS Kaplan	Annals of the New York Academy of Sciences	2006
Function of BMPs and BMP Antagonists in Adult Bone E Abe	Annals of the New York Academy of Sciences	2006
BMP and BMP Inhibitors in Bone V Rosen	Annals of the New York Academy of Sciences	2006
EFFECTS OF ULMUS DAVIDIANA PLANCH ON MINERALIZATION, BONE MORPHOGENETIC PROTEIN-2, ALKALINE PHOSPHATASE, TYPE I COLLAGEN, AND COLLAGENASE-1 IN BONE CELLS SK Kang, KS Kim, YS Byun, SJ Suh, UH Jim, KH Kim, IS Lee, CH Kim	In vitro cellular & developmental biology. Animal	2006
Noggin improves bone healing elicited by muscle stem cells expressing inducible BMP4 H Peng, A Usas, D Hannallah, A Olshanski, GM Cooper, J Huard	Molecular Therapy	2005
Heterotopic ossification: a review EF McCarthy, M Sundaram	Skeletal Radiology	2005
Influence of BMPs on the Formation of Osteoblastic Lesions in Metastatic Prostate Cancer BT Feeley, SC Gamradt, WK Hsu, N Liu, L Krenek, P Robbins, J Huard, JR Lieberman	Journal of Bone and Mineral Research	2005
Gene therapy for spinal fusion FM Phillips, PM Bolt, TC He, RC Haydon	The Spine Journal	2005
Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential A Fakhry, C Ratisoontorn, C Vedhachalam, I Salhab, E Koyama, P Leboy, M Pacifici, RE Kirschner, HD Nah	Bone	2005
Twisted gastrulation and chordin inhibit differentiation and mineralization in MC3T3-E1 osteoblast-like cells A Petryk, O Shimmi, X Jia, AE Carlson, L Tervonen, MP Jarcho, MB O'Connor, R Gopalakrishnan	Bone	2005
Low dose fibroblast growth factor-2 (FGF-2) enhances bone morphogenetic protein-2 (BMP-2)-induced ectopic bone formation in mice Y Nakamura, K Tensho, H Nakaya, M Nawata, T Okabe, S Wakitani	Bone	2005
BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos LW Gamer, J Nove, M Levin, V Rosen	Developmental Biology	2005
Current concepts of molecular aspects of bone healing R Dimitriou, E Tsiridis, PV Giannoudis	Injury	2005
Use of bone morphogenetic proteins in traumatology RJ Westerhuis, RL Bezooijen, P Kloen	Injury	2005
Discovery and development of BMPs R Dimitriou, PV Giannoudis	Injury	2005
Expression profiles of BMP-related molecules induced by BMP-2 or -4 in muscle-derived primary culture cells Y Nakamura, S Wakitani, N Saito, K Takaoka	Journal of Bone and Mineral Metabolism	2005
Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through arunt domain factor 2 binding site S Varghese, S Rydziel, E Canalis	Journal of Cellular Physiology	2004
Negative regulation of TGF-β signaling in development YG CHEN, AM MENG	Cell Research	2004
Genetic models for transforming growth factor β superfamily signaling in ovarian follicle development SA Pangas, MM Matzuk	Molecular and Cellular Endocrinology	2004
Follistatin Restricts Bone Morphogenetic Protein (BMP)-2 Action on the Differentiation of Osteoblasts in Fetal Rat Mandibular Cells Y Abe, T Abe, Y Aida, Y Hara, K Maeda	Journal of Bone and Mineral Research	2004
Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts MK Sutherland, JC Geoghegan, C Yu, DG Winkler, JA Latham	Bone	2004
Drynariae Rhizoma promotes osteoblast differentiation and mineralization in MC3T3-E1 cells through regulation of bone morphogenetic protein-2, alkaline phosphatase, type I collagen and collagenase-1 JC Jeong, JW Lee, CH Yoon, HM Kim, CH Kim	Toxicology in Vitro	2004
On the narrow dip structure at 1.9 GeV/c2 in diffractive photoproduction PL Frabetti, HW Cheung, JP Cumalat, C Dallapiccola, JF Ginkel, WE Johns, MS Nehring, EW Vaandering, JN Butler, S Cihangir, I Gaines, PH Garbincius, L Garren, SA Gourlay, DJ Harding, P Kasper, A Kreymer, P Lebrun, S Shukla, M Vittone, R Baldini-Ferroli, L Benussi, M Bertani, S Bianco, FL Fabbri, S Pacetti, A Zallo, C Cawlfield, R Culbertson, RW Gardner, E Gottschalk, R Greene, K Park, A Rahimi, J Wiss, G Alimonti, G Bellini, M Boschini, D Brambilla, B Caccianiga, L Cinquini, M DiCorato, P Dini, M Giammarchi, P Inzani, F Leveraro, S Malvezzi, D Menasce, E Meroni, L Milazzo, L Moroni, D Pedrini, L Perasso, F Prelz, A Sala, S Sala, D Torretta, D Buchholz, D Claes, B Gobbi, B O'Reilly, JM Bishop, NM Cason, CJ Kennedy, GN Kim, TF Lin, DL Puseljic, RC Ruchti, WD Shephard, JA Swiatek, ZY Wu, V Arena, G Boca, G Bonomi, C Castoldi, G Gianini, M Merlo, SP Ratti, C Riccardi, L Viola, P Vitulo, AM Lopez, L Mendez, A Mirles, E Montiel, D Olaya, JE Ramirez, C Rivera, Y Zhang, JM Link, VS Paolone, PM Yager, JR Wilson, J Cao, M Hosack, PD Sheldon, F Davenport, K Cho, K Danyo, T Handler, BG Cheon, YS Chung, JS Kang, KY Kim, KB Lee, SS Myung	Developmental Biology	2004
Heterotopic Ossification: FS Kaplan, DL Glaser, N Hebela, EM Shore	The Journal of the American Academy of Orthopaedic Surgeons	2004
Growth Differentiation Factor 9 Regulates Expression of the Bone Morphogenetic Protein Antagonist Gremlin SA Pangas, CJ Jorgez, MM Matzuk	The Journal of biological chemistry	2004
FGF18 Represses Noggin Expression and Is Induced by Calcineurin MI Reinhold, M Abe, RM Kapadia, Z Liao, MC Naski	The Journal of biological chemistry	2004
Noggin and Sclerostin Bone Morphogenetic Protein Antagonists Form a Mutually Inhibitory Complex DG Winkler, C Yu, JC Geoghegan, EW Ojala, JE Skonier, D Shpektor, MK Sutherland, JA Latham	The Journal of biological chemistry	2004
Bone Morphogenetic Proteins: Regeneration of Bone and Beyond S Vukicevic, KT Sampath		2004
Bone Formation F Bronner, MC Farach-Carson		2004
Impaired Osteoblastic Differentiation, Reduced Bone Formation and Severe Osteoporosis in Noggin Overexpressing Mice Reveal New Insights into the Pathogenesis of Involutional Osteoporosis Xue-Bin Wu, Yanan Li, Adina Schneider, Wanqin Yu, Gopalan Rajendren, Jameel Iqbal, Matsuo Yamamoto, Mohammad Alam, Lisa J. Brunet, Robert M Harland, Harry C Blair, Mone Zaidi, Etsuko Abe	Journal of Clinical Investigation	2003
Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology* VA Botchkarev	Journal of Investigative Dermatology	2003
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist DG Winkler, MK Sutherland, JC Geoghegan, C Yu, T Hayes, JE Skonier, D Shpektor, M Jonas, BR Kovacevich, K Staehling-Hampton, M Appleby, ME Brunkow, JA Latham	The EMBO Journal	2003
Gene therapy of bone morphogenetic protein for periodontal tissue engineering QM Jin, O Anusaksathien, SA Webb, RB Rutherford, WV Giannobile	Journal of Periodontology	2003
Regulation of BMP-induced transcription in cultured human bone marrow stromal cells DL Diefenderfer, AM Osyczka, JP Garino, PS Leboy	The Journal of bone and joint surgery. American volume	2003
Temporal and Spatial Expression Profiles of BMP Receptors and Noggin During BMP-2-Induced Ectopic Bone Formation Y Nakamura, S Wakitani, J Nakayama, S Wakabayashi, H Horiuchi, K Takaoka	Journal of Bone and Mineral Research	2003
Noggin arrests stromal cell differentiation in vitro☆☆This work was supported by Grant AR21707 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Grant DK45227 from the National Institute of Diabetes, Digestive and Kidney Diseases E Gazzerro, Z Du, RD Devlin, S Rydziel, L Priest, AN Economides, E Canalis	Bone	2003
The BMP antagonist noggin regulates cranial suture fusion SM Warren, LJ Brunet, RM Harland, AN Economides, MT Longaker	Nature	2003
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling Y Yoshida, A Bubnoff, N Ikematsu, IL Blitz, JK Tsuzuku, EH Yoshida, H Umemori, K Miyazono, T Yamamoto, KW Cho	Mechanisms of Development	2003
Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation J Guicheux, J Lemonnier, C Ghayor, A Suzuki, G Palmer, J Caverzasio	Journal of Bone and Mineral Research	2003
Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton E Canalis, AN Economides, E Gazzerro	Endocrine reviews	2003
BMP Responsiveness in Human Mesenchymal Stem Cells DL Diefenderfer, AM Osyczka, GC Reilly, PS Leboy	Connective Tissue Research	2003
Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals HL Chen, PJ Lein, JY Wang, D Gash, BJ Hoffer, YH Chiang	Brain Research	2003
IN VIVO SOMATIC CELL GENE TRANSFER OF AN ENGINEERED NOGGIN MUTEIN PREVENTS BMP4-INDUCED HETEROTOPIC OSSIFICATION: DL Glaser, AN Economides, L Wang, X Liu, RD Kimble, JP Fandl, JM Wilson, N Stahl, FS Kaplan, EM Shore	The Journal of Bone and Joint Surgery. American volume.	2003
REGULATION OF BMP-INDUCED TRANSCRIPTION IN CULTURED HUMAN BONE MARROW STROMAL CELLS: DL Diefenderfer, AM Osyczka, JP Garino, PS Leboy	The Journal of Bone and Joint Surgery. American volume.	2003
PARESIS OF A BONE MORPHOGENETIC PROTEIN-ANTAGONIST RESPONSE IN A GENETIC DISORDER OF HETEROTOPIC SKELETOGENESIS: J Ahn, LS de la Peña, EM Shore, FS Kaplan	The Journal of Bone and Joint Surgery. American volume.	2003
Protein Kinase C-independent Activation of Protein Kinase D Is Involved in BMP-2-induced Activation of Stress Mitogen-activated Protein Kinases JNK and p38 and Osteoblastic Cell Differentiation J Lemonnier, C Ghayor, J Guicheux, J Caverzasio	The Journal of biological chemistry	2003
Stage specific inhibition of osteoblast lineage differentiation by FGF2 and noggin I Kalajzic, Z Kalajzic, MM Hurley, AC Lichtler, DW Rowe	Journal of Cellular Biochemistry	2003
Exoneration of NF-??B Dysregulation in Fibrodysplasia Ossificans Progressiva: J Ahn, G Feldman, L Terry, EM Shore, FS Kaplan	Clinical Orthopaedics and Related Research®	2003
Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression RC Pereira, AM Delany, E Canalis	Bone	2002
The other side of TGF-β superfamily signal regulation: thinking outside the cell TL Gumienny, RW Padgett	Trends in Endocrinology & Metabolism	2002
Advances in Cell Aging and Gerontology T Fülöp, K Hirokawa, G Dupuis, A Larbi, G Pawelec	Advances in Cell Aging and Gerontology	2002
Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators W Balemans, WV Hul	Developmental Biology	2002
Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function L Bartholin, V Maguer-Satta, S Hayette, S Martel, M Gadoux, L Corbo, JP Magaud, R Rimokh	Oncogene	2002
The Effect of Osteogenic Protein-1 in an In Vivo Physeal Injury Model: EW Johnstone, M McArthur, PB Solly, K Higginson, S Byers, BK Foster	Clinical Orthopaedics and Related Research®	2002
Clinical Evaluation of Recombinant Human Bone Morphogenetic Protein-2: A Valentin-Opran, J Wozney, C Csimma, L Lilly, GE Riedel	Clinical Orthopaedics and Related Research®	2002
Glia induce dendritic growth in cultured sympathetic neurons by modulating the balance between bone morphogenetic proteins (BMPs) and BMP antagonists Pamela J Lein, Hiroko Nagasawa Beck, Vidya Chandrasekaran, Patrick J Gallagher, Hui-Ling Chen, Yuan Lin, Xin Guo, Paul L Kaplan, Henri Tiedge, Dennis Higgins	The Journal of neuroscience : the official journal of the Society for Neuroscience	2002
Peri-implant bone regeneration using recombinant human bone morphogenetic protein-2 in a canine model: a dose-response study: rhBMP-2 dose in peri-implant regeneration DN Tatakis, A Koh, L Jin, JM Wozney, MD Rohrer, UM Wikesjö	Journal of Periodontal Research	2002
Glia Induce Dendritic Growth in Cultured Sympathetic Neurons by Modulating the Balance between Bone Morphogenetic Proteins (BMPs) and BMP Antagonists Lein PJ, Beck HN, Chandrasekaran V, Gallagher PJ, Chen HL, Lin Y, Guo X, Kaplan PL, Tiedge H, Higgins D	Journal of Neuroscience	2002
Noggin is required for induction of the hair follicle growth phase in postnatal skin VA Botchkarev, NV Botchkareva, M Nakamura, O Huber, K Funa, R Lauster, R Paus, BA Gilchrest	The FASEB Journal	2001
Simvastatin Promotes Osteoblast Differentiation and Mineralization in MC3T3-E1 Cells T Maeda, A Matsunuma, T Kawane, N Horiuchi	Biochemical and Biophysical Research Communications	2001
Colocalization of Noggin and Bone Morphogenetic Protein-4 During Fracture Healing Y Yoshimura, S Nomura, S Kawasaki, T Tsutsumimoto, T Shimizu, K Takaoka	Journal of Bone and Mineral Research	2001
The Bone Morphogenetic Proteins Antagonist Noggin Inhibits Membranous Ossification P Aspenberg, C Jeppsson, AN Economides	Journal of Bone and Mineral Research	2001
The BMP Antagonists Chordin and Noggin Have Essential but Redundant Roles in Mouse Mandibular Outgrowth RW Stottmann, RM Anderson, J Klingensmith	Developmental Biology	2001
The Parathyroids SJ Marx	The Parathyroids	2001
Gdf11 Is a Negative Regulator of Chondrogenesis and Myogenesis in the Developing Chick Limb LW Gamer, KA Cox, C Small, V Rosen	Developmental Biology	2001
Bone Mechanics Handbook, Second Edition R Majeska	Bone Mechanics Handbook, Second Edition	2001
Essential Requirement of BMPs-2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures from Adult Mice: Antagonism by Noggin E Abe, M Yamamoto, Y Taguchi, B Lecka-Czernik, CA O'Brien, AN Economides, N Stahl, RL Jilka, SC Manolagas	Journal of Bone and Mineral Research	2000
Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN AH Reddi	Arthritis research	2000
Bone morphogenetic protein-4 regulates its own expression in cultured osteoblasts RC Pereira, S Rydziel, E Canalis	Journal of Cellular Physiology	2000
BMP-2 induces the expression of activin ?A and follistatin in vitro AE Kearns, MB Demay	Journal of Cellular Biochemistry	2000
Linkage exclusion and mutational analysis of the noggin gene in patients with fibrodysplasia ossificans progressiva (FOP) MQ Xu, G Feldman, ML Merrer, YY Shugart, DL Glaser, JA Urtizberea, M Fardeau, JM Connor, J Triffitt, R Smith, EM Shore, FS Kaplan	Clinical Genetics	2000
Bone Morphogenetic Proteins Secreted by Breast Cancer Cells Upregulate Bone Sialoprotein Expression in Preosteoblast Cells P Bunyaratavej, TG Hullinger, MJ Somerman	Experimental Cell Research	2000
Smad6 Is a Smad1/5-induced Smad Inhibitor: CHARACTERIZATION OF BONE MORPHOGENETIC PROTEIN-RESPONSIVE ELEMENT IN THE MOUSE Smad6 PROMOTER W Ishida, T Hamamoto, K Kusanagi, K Yagi, M Kawabata, K Takehara, TK Sampath, M Kato, K Miyazono	The Journal of biological chemistry	2000
How cells read TGF-β signals J Massagué	Nature Reviews Molecular Cell Biology	2000
Fate and function of the ventral ectodermal ridge during mouse tail development DC Goldman, GR Martin, PP Tam	Development (Cambridge, England)	2000
Positive and negative regulation of TGF-beta signaling K Miyazono	Journal of cell science	2000
Growth Factor Regulation of Fracture Repair GL Barnes, PJ Kostenuik, LC Gerstenfeld, TA Einhorn	Journal of Bone and Mineral Research	1999
Noggin and Bone Morphogenetic Protein-4 Coordinately Regulate the Progression of Chondrogenic Differentiation in Mouse Clonal EC Cells, ATDC5 H Ito, H Akiyama, C Shigeno, T Nakamura	Biochemical and Biophysical Research Communications	1999
Extracellular modulation of the Hedgehog, Wnt and TGF-β signalling pathways during embryonic development J Capdevila, JC Belmonte	Current Opinion in Genetics & Development	1999
Coordinated Expression of Noggin and Bone Morphogenetic Proteins (BMPs) During Early Skeletogenesis and Induction of Noggin Expression by BMP-7 A Nifuji, M Noda	Journal of Bone and Mineral Research	1999
Osteoporosis DL Glaser, FS Kaplan	Spine	1997
Progress in Brain Research DE van Epps, L Saland, C Taylor, RC Williams	Progress in brain research	1983

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