Citations to this article
Abstract
Factors involved in determining whether infectious mononucleosis occurs after primary EBV infection may include age, dose of virus received, and various genetic markers. A study by McAulay and colleagues reported in this issue of the JCI shows that the presence of certain HLA class I alleles correlates with the incidence and severity of infectious mononucleosis (see the related article beginning on page 3042). These same HLA alleles are also risk factors for EBV-associated Hodgkin lymphoma (HL), supporting recent epidemiology that indicates that a history of infectious mononucleosis predisposes to HL. Recent studies suggest that an EBV vaccine might help to prevent infectious mononucleosis, and further development of this should now be considered.
Authors
Paul J. Farrell
Citations to this article (3)
| Title and authors | Publication | Year |
|---|---|---|
|
The Epstein-Barr Virus Lytic Protein BZLF1 as a Candidate Target Antigen for Vaccine Development
AS Hartlage, T Liu, JT Patton, SL Garman, X Zhang, H Kurt, G Lozanski, ME Lustberg, MA Caligiuri, RA Baiocchi |
Cancer immunology research | 2015 |
|
Evidence of genetic susceptibility to infectious mononucleosis: a twin study
AE Hwang, AS Hamilton, MG Cockburn, R Ambinder, J Zadnick, EE Brown, TM Mack, W Cozen |
Epidemiology and Infection | 2011 |
|
The causal cascade to multiple sclerosis: a model for MS pathogenesis
DS Goodin |
PloS one | 2009 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)