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Citations to this article

Chemical modification: the key to clinical application of RNA interference?
David R. Corey
David R. Corey
Published December 3, 2007
Citation Information: J Clin Invest. 2007;117(12):3615-3622. https://doi.org/10.1172/JCI33483.
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Chemical modification: the key to clinical application of RNA interference?

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Abstract

RNA interference provides a potent and specific method for controlling gene expression in human cells. To translate this potential into a broad new family of therapeutics, it is necessary to optimize the efficacy of the RNA-based drugs. As discussed in this Review, it might be possible to achieve this optimization using chemical modifications that improve their in vivo stability, cellular delivery, biodistribution, pharmacokinetics, potency, and specificity.

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David R. Corey

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
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