MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets
Eva van Rooij, Eric N. Olson
Eva van Rooij, Eric N. Olson
Published September 4, 2007
Citation Information: J Clin Invest. 2007;117(9):2369-2376. https://doi.org/10.1172/JCI33099.
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MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

Abstract

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

Authors

Eva van Rooij, Eric N. Olson

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