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MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets
Eva van Rooij, Eric N. Olson
Eva van Rooij, Eric N. Olson
Published September 4, 2007
Citation Information: J Clin Invest. 2007;117(9):2369-2376. https://doi.org/10.1172/JCI33099.
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Science in Medicine Article has an altmetric score of 9

MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

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Abstract

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

Authors

Eva van Rooij, Eric N. Olson

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Figure 4

Requirement of miR-208 for cardiomyocyte hypertrophy and fibrosis.

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Requirement of miR-208 for cardiomyocyte hypertrophy and fibrosis.
(A) S...
(A) Schematic diagram of a heart following thoracic aortic banding (TAB). (B) Sections of hearts of approximately 3-month-old wild-type and miR-208–/– mice are shown following sham operation or TAB for 21 days. High-magnification views of the ventricular wall are shown at the bottom. Trichrome staining identifies fibrosis in blue. Note that hypertrophy and fibrosis are diminished in miR208–/– mice compared with wild-type following TAB. Scale bars: 2 mm (top); 20 μm (bottom). Reproduced with permission from Science (5).

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 24 patents
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