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MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets
Eva van Rooij, Eric N. Olson
Eva van Rooij, Eric N. Olson
Published September 4, 2007
Citation Information: J Clin Invest. 2007;117(9):2369-2376. https://doi.org/10.1172/JCI33099.
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Science in Medicine Article has an altmetric score of 9

MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

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Abstract

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

Authors

Eva van Rooij, Eric N. Olson

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Figure 3

Roles of specific miRNAs in cardiac hypertrophy.

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Roles of specific miRNAs in cardiac hypertrophy.
Stress signals drive a ...
Stress signals drive a pathological remodeling response of the adult heart, which is characterized by hypertrophy, ventricular dilatation, and fibrosis. miR-208 is required for stress-dependent remodeling and miR-195, which is induced by cardiac stress, is sufficient to drive cardiac remodeling. miR-133 appears to play a negative role in cardiac hypertrophy (5, 6, 8).

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 24 patents
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